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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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Results for ALX1_ARX

Z-value: 0.99

Motif logo

Transcription factors associated with ALX1_ARX

Gene Symbol	Gene ID	Gene Info
ALX1 Ensembl NCBI GeneCards UniProt	ENSG00000180318.3	ALX homeobox 1
ARX Ensembl NCBI GeneCards UniProt	ENSG00000004848.6	aristaless related homeobox

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr12_85674758_85674967	ALX1	977	0.713321	-0.79	1.1e-02	Click!
chr12_85667418_85667569	ALX1	6392	0.325862	-0.79	1.2e-02	Click!
chr12_85667142_85667320	ALX1	6654	0.323824	-0.73	2.6e-02	Click!
chr12_85673718_85673869	ALX1	92	0.984809	-0.67	4.8e-02	Click!
chr12_85673938_85674715	ALX1	441	0.905998	-0.61	7.9e-02	Click!
chrX_25038714_25038865	ARX	4724	0.295014	0.80	9.0e-03	Click!
chrX_25022630_25023098	ARX	11201	0.268828	-0.80	9.3e-03	Click!
chrX_25022267_25022418	ARX	11723	0.267664	-0.73	2.6e-02	Click!
chrX_25039041_25039573	ARX	5242	0.287584	0.61	7.8e-02	Click!
chrX_25025059_25025364	ARX	8854	0.274973	-0.58	1.0e-01	Click!

Activity of the ALX1_ARX motif across conditions

Conditions sorted by the z-value of the ALX1_ARX motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr10_677138_677289	2.41	RP11-809C18.3		2635	0.23
chr2_225809390_225809894	1.74	DOCK10	dedicator of cytokinesis 10	2140	0.45
chr4_40201182_40201333	1.35	RHOH	ras homolog family member H	707	0.72
chr12_118796178_118796667	1.33	TAOK3	TAO kinase 3	488	0.85
chr10_30745504_30745655	1.25	MAP3K8	mitogen-activated protein kinase kinase kinase 8	17828	0.21
chr4_46115537_46115688	1.22	GABRG1	gamma-aminobutyric acid (GABA) A receptor, gamma 1	10486	0.3
chr1_192546230_192546423	1.19	RGS1	regulator of G-protein signaling 1	1423	0.45
chr3_151961363_151961565	1.11	MBNL1	muscleblind-like splicing regulator 1	24365	0.2
chr5_44684027_44684178	1.10	ENSG00000263556	.	32190	0.23
chr5_96294037_96294231	1.09	LNPEP	leucyl/cystinyl aminopeptidase	21	0.98
chr15_93427252_93427403	1.07	CHD2	chromodomain helicase DNA binding protein 2	801	0.63
chr3_63954232_63954647	1.05	ATXN7	ataxin 7	1019	0.48
chr12_82826657_82826808	1.05	METTL25	methyltransferase like 25	33594	0.21
chr1_192547268_192547419	1.00	RGS1	regulator of G-protein signaling 1	2440	0.31
chr13_74806186_74806399	0.97	ENSG00000206617	.	57059	0.16
chr3_63956535_63956875	0.91	ATXN7	ataxin 7	3285	0.2
chr4_143488164_143488362	0.90	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	6441	0.35
chrX_135861825_135862156	0.89	ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	2257	0.28
chr7_7298568_7298818	0.89	C1GALT1	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1	24742	0.22
chr12_105035462_105035613	0.89	ENSG00000264295	.	50126	0.15
chr16_53469656_53469844	0.87	RBL2	retinoblastoma-like 2 (p130)	219	0.92
chr10_82259532_82259683	0.84	RP11-137H2.4		36091	0.14
chr3_151922152_151922513	0.84	MBNL1	muscleblind-like splicing regulator 1	63497	0.12
chr14_99707128_99707406	0.84	AL109767.1		22018	0.2
chr5_40685237_40685679	0.79	PTGER4	prostaglandin E receptor 4 (subtype EP4)	5858	0.22
chr1_117301810_117301961	0.79	CD2	CD2 molecule	4796	0.25
chr1_29253817_29254129	0.78	EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	12882	0.18
chr3_43329409_43329595	0.78	SNRK	SNF related kinase	1424	0.43
chrX_117750069_117750220	0.77	ENSG00000206862	.	46666	0.16
chr10_8101958_8102217	0.76	GATA3	GATA binding protein 3	5318	0.35
chr12_46611391_46611598	0.76	SLC38A1	solute carrier family 38, member 1	49990	0.18
chr5_115175043_115175345	0.76	AP3S1	adaptor-related protein complex 3, sigma 1 subunit	1984	0.26
chrX_35788537_35788688	0.76	MAGEB16	melanoma antigen family B, 16	27847	0.25
chr7_129620661_129620812	0.75	ENSG00000263557	.	4851	0.14
chr2_10444029_10444225	0.75	HPCAL1	hippocalcin-like 1	301	0.89
chr1_111744675_111744826	0.74	CHI3L2	chitinase 3-like 2	1357	0.27
chr6_143264540_143264691	0.74	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	1723	0.46
chr1_102637571_102637722	0.73	OLFM3	olfactomedin 3	175060	0.04
chr13_99957828_99957979	0.72	GPR183	G protein-coupled receptor 183	1756	0.38
chr11_46141542_46141818	0.72	PHF21A	PHD finger protein 21A	267	0.92
chr1_7999953_8000204	0.72	TNFRSF9	tumor necrosis factor receptor superfamily, member 9	848	0.6
chr9_82427530_82428232	0.71	TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	106200	0.08
chr7_37381672_37381823	0.71	ELMO1	engulfment and cell motility 1	620	0.76
chr14_22947593_22947744	0.71	TRAJ60	T cell receptor alpha joining 60 (pseudogene)	2372	0.15
chr7_23338458_23338640	0.71	MALSU1	mitochondrial assembly of ribosomal large subunit 1	270	0.93
chr11_6765821_6765972	0.71	GVINP1	GTPase, very large interferon inducible pseudogene 1	22785	0.11
chr17_38018344_38018495	0.71	IKZF3	IKAROS family zinc finger 3 (Aiolos)	1960	0.26
chr4_154411300_154411567	0.69	KIAA0922	KIAA0922	23932	0.22
chr17_75456326_75456913	0.69	SEPT9	septin 9	4171	0.18
chr1_198652510_198652661	0.69	RP11-553K8.5		16395	0.24
chr1_226251298_226251924	0.69	H3F3A	H3 histone, family 3A	67	0.97
chr14_88472278_88472651	0.68	GPR65	G protein-coupled receptor 65	996	0.51
chrX_128914916_128915218	0.68	SASH3	SAM and SH3 domain containing 3	1107	0.52
chr16_81748402_81748687	0.68	PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	24158	0.24
chr6_25040218_25040369	0.68	RP3-425P12.5		1774	0.29
chr2_158299843_158300108	0.68	CYTIP	cytohesin 1 interacting protein	679	0.68
chr17_48793783_48793934	0.67	LUC7L3	LUC7-like 3 (S. cerevisiae)	3047	0.17
chrX_28529887_28530038	0.67	IL1RAPL1	interleukin 1 receptor accessory protein-like 1	75554	0.12
chr2_204802372_204802523	0.67	ICOS	inducible T-cell co-stimulator	944	0.69
chr2_197029492_197029688	0.66	STK17B	serine/threonine kinase 17b	6134	0.21
chr2_161993456_161993757	0.66	TANK	TRAF family member-associated NFKB activator	140	0.97
chr1_89354888_89355039	0.66	GTF2B	general transcription factor IIB	2216	0.34
chr5_129840711_129840862	0.66	ENSG00000252514	.	118413	0.07
chr10_77531854_77532472	0.65	C10orf11	chromosome 10 open reading frame 11	10356	0.22
chr15_74583791_74583942	0.64	RP11-60L3.2		11480	0.15
chr3_195276037_195276188	0.64	AC091633.3		2693	0.22
chr2_174129320_174129481	0.63	MLK7-AS1	MLK7 antisense RNA 1	6948	0.3
chr11_14669296_14669647	0.62	PDE3B	phosphodiesterase 3B, cGMP-inhibited	4094	0.26
chr12_132671196_132671356	0.62	GALNT9	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)	19061	0.17
chr3_30650173_30650487	0.61	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	2237	0.45
chr1_198612556_198613143	0.61	PTPRC	protein tyrosine phosphatase, receptor type, C	4557	0.28
chr3_40518130_40518400	0.61	ZNF619	zinc finger protein 619	339	0.84
chr2_158295494_158296053	0.60	CYTIP	cytohesin 1 interacting protein	153	0.96
chr11_82461800_82462168	0.60	FAM181B	family with sequence similarity 181, member B	17078	0.25
chr1_198664326_198664477	0.60	RP11-553K8.5		28211	0.22
chr13_97874593_97875664	0.59	MBNL2	muscleblind-like splicing regulator 2	519	0.87
chr21_25801249_25801648	0.59	ENSG00000232512	.	671997	0.0
chr5_98108921_98109207	0.59	RGMB-AS1	RGMB antisense RNA 1	109	0.73
chr4_154418637_154418870	0.59	KIAA0922	KIAA0922	31252	0.2
chr14_22977314_22977663	0.59	TRAJ15	T cell receptor alpha joining 15	21092	0.09
chr20_35575234_35575857	0.58	SAMHD1	SAM domain and HD domain 1	4566	0.25
chr5_96295111_96295262	0.58	LNPEP	leucyl/cystinyl aminopeptidase	1031	0.51
chr16_22383801_22383959	0.57	CDR2	cerebellar degeneration-related protein 2, 62kDa	2058	0.22
chr14_102342635_102343008	0.57	PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	7053	0.2
chr1_28441500_28441651	0.56	EYA3	eyes absent homolog 3 (Drosophila)	26368	0.11
chr2_143887583_143887860	0.56	ARHGAP15	Rho GTPase activating protein 15	838	0.72
chr15_65592052_65592203	0.56	ENSG00000199568	.	3738	0.15
chr16_71935673_71935824	0.56	IST1	increased sodium tolerance 1 homolog (yeast)	6256	0.13
chr1_89737700_89738180	0.55	GBP5	guanylate binding protein 5	547	0.77
chr1_193506744_193506895	0.55	ENSG00000252241	.	194255	0.03
chr14_22461559_22461710	0.55	ENSG00000238634	.	149253	0.04
chr18_77283391_77284187	0.55	AC018445.1	Uncharacterized protein	7732	0.29
chr6_112078365_112078719	0.55	FYN	FYN oncogene related to SRC, FGR, YES	1775	0.47
chr5_37198039_37198190	0.54	C5orf42	chromosome 5 open reading frame 42	15610	0.24
chr2_27273737_27274028	0.54	AGBL5	ATP/GTP binding protein-like 5	6	0.9
chr13_67288038_67288189	0.54	ENSG00000238500	.	83205	0.1
chr7_50415328_50415483	0.54	IKZF1	IKAROS family zinc finger 1 (Ikaros)	48160	0.16
chr7_37381509_37381660	0.54	ELMO1	engulfment and cell motility 1	783	0.68
chr6_119212181_119212332	0.54	ASF1A	anti-silencing function 1A histone chaperone	3128	0.28
chr1_167483926_167484083	0.54	CD247	CD247 molecule	3771	0.25
chr16_81030456_81031156	0.53	CMC2	C-x(9)-C motif containing 2	1458	0.31
chr10_3989446_3989597	0.53	KLF6	Kruppel-like factor 6	162048	0.04
chr10_17687713_17687972	0.53	STAM	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	1578	0.29
chr8_66751055_66751459	0.53	PDE7A	phosphodiesterase 7A	274	0.95
chr21_15917916_15918619	0.52	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	395	0.89
chr10_6964732_6964883	0.52	PRKCQ	protein kinase C, theta	342544	0.01
chr12_111868224_111868441	0.52	SH2B3	SH2B adaptor protein 3	4334	0.21
chr5_130882612_130883040	0.52	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	14100	0.29
chr14_34650062_34650213	0.52	EGLN3	egl-9 family hypoxia-inducible factor 3	41946	0.2
chr13_68238536_68238687	0.52	PCDH9	protocadherin 9	434143	0.01
chr21_32563083_32563234	0.51	TIAM1	T-cell lymphoma invasion and metastasis 1	60619	0.14
chr3_151923453_151923604	0.51	MBNL1	muscleblind-like splicing regulator 1	62301	0.13
chr12_32113291_32114105	0.51	KIAA1551	KIAA1551	1345	0.51
chr9_92079076_92079388	0.51	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	8364	0.24
chr14_70111468_70111619	0.51	KIAA0247	KIAA0247	33230	0.18
chr5_148726675_148726837	0.51	GRPEL2	GrpE-like 2, mitochondrial (E. coli)	1691	0.25
chr12_92532725_92532888	0.51	C12orf79	chromosome 12 open reading frame 79	2009	0.29
chr7_106507057_106507208	0.50	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	1208	0.59
chr9_96227429_96227580	0.50	FAM120AOS	family with sequence similarity 120A opposite strand	11630	0.14
chr4_140886144_140886295	0.50	MAML3	mastermind-like 3 (Drosophila)	74098	0.11
chr19_42056193_42056486	0.50	CEACAM21	carcinoembryonic antigen-related cell adhesion molecule 21	453	0.8
chr15_72754102_72754312	0.50	ARIH1	ariadne RBR E3 ubiquitin protein ligase 1	12460	0.2
chr3_45010992_45011143	0.50	ZDHHC3	zinc finger, DHHC-type containing 3	6591	0.16
chr2_68962051_68962936	0.50	ARHGAP25	Rho GTPase activating protein 25	479	0.86
chrX_2276063_2276214	0.50	DHRSX-IT1	DHRSX intronic transcript 1 (non-protein coding)	21687	0.26
chrY_2226062_2226213	0.49	ENSG00000251841	.	426653	0.01
chrY_17633910_17634061	0.49	ENSG00000252664	.	540661	0.0
chr2_158292578_158292753	0.49	CYTIP	cytohesin 1 interacting protein	3261	0.28
chr14_102285064_102285215	0.49	CTD-2017C7.2		8481	0.15
chr10_3514525_3515428	0.49	RP11-184A2.3		278283	0.01
chr6_35635788_35636125	0.49	ENSG00000265527	.	3390	0.18
chr1_160614457_160614608	0.49	SLAMF1	signaling lymphocytic activation molecule family member 1	2279	0.26
chr7_152373399_152373635	0.48	XRCC2	X-ray repair complementing defective repair in Chinese hamster cells 2	267	0.92
chr18_830449_831025	0.48	YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	18190	0.15
chr2_55236581_55236732	0.48	RTN4	reticulon 4	929	0.6
chr22_19098122_19098273	0.48	AC004471.9		10845	0.11
chr10_17701952_17702103	0.48	STAM	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	15763	0.14
chr1_84610455_84610717	0.48	PRKACB	protein kinase, cAMP-dependent, catalytic, beta	632	0.82
chr17_33868045_33868636	0.48	SLFN12L	schlafen family member 12-like	3460	0.14
chr2_204801338_204802214	0.48	ICOS	inducible T-cell co-stimulator	273	0.95
chr10_63993468_63993619	0.48	RTKN2	rhotekin 2	2479	0.4
chr7_33078848_33079779	0.48	NT5C3A	5'-nucleotidase, cytosolic IIIA	1208	0.42
chr5_87798376_87798680	0.48	TMEM161B-AS1	TMEM161B antisense RNA 1	76016	0.11
chr13_87752560_87752711	0.47	ENSG00000266052	.	518360	0.0
chr6_149729706_149729857	0.47	SUMO4	small ubiquitin-like modifier 4	8286	0.19
chr1_111212990_111213454	0.47	KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	4433	0.21
chr3_111043169_111043480	0.47	CD96	CD96 molecule	31758	0.24
chr14_90084669_90085459	0.47	FOXN3	forkhead box N3	410	0.78
chr6_106547996_106548204	0.47	RP1-134E15.3		85	0.96
chr2_74406078_74406319	0.47	MOB1A	MOB kinase activator 1A	203	0.91
chr6_24932242_24932425	0.47	FAM65B	family with sequence similarity 65, member B	3855	0.28
chr2_237446552_237446703	0.46	ACKR3	atypical chemokine receptor 3	29803	0.19
chr4_124343109_124343622	0.46	SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	22242	0.29
chr12_110432591_110433205	0.46	GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	1131	0.48
chr2_213962198_213962349	0.46	IKZF2	IKAROS family zinc finger 2 (Helios)	51080	0.16
chr17_55336943_55337094	0.46	MSI2	musashi RNA-binding protein 2	2639	0.38
chr2_120687485_120687636	0.45	PTPN4	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)	208	0.95
chr10_121487824_121487975	0.45	INPP5F	inositol polyphosphate-5-phosphatase F	2290	0.34
chrX_119619280_119620483	0.45	LAMP2	lysosomal-associated membrane protein 2	16661	0.2
chr20_57232821_57232972	0.45	STX16	syntaxin 16	5833	0.18
chrX_31453419_31453570	0.45	ENSG00000252903	.	87185	0.1
chr11_104838069_104839428	0.45	CASP4	caspase 4, apoptosis-related cysteine peptidase	1345	0.45
chr6_41038995_41039315	0.45	OARD1	O-acyl-ADP-ribose deacylase 1	424	0.72
chr6_149641931_149642082	0.45	TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	182	0.95
chr12_42492275_42492426	0.44	ENSG00000222884	.	18787	0.22
chr4_40210765_40210916	0.44	RHOH	ras homolog family member H	8876	0.22
chr7_137619960_137620169	0.44	CREB3L2	cAMP responsive element binding protein 3-like 2	1428	0.46
chr12_104871725_104872091	0.44	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	21129	0.25
chrX_78401406_78401924	0.44	GPR174	G protein-coupled receptor 174	24804	0.27
chr5_67580506_67580669	0.44	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	3609	0.36
chrX_24072515_24072689	0.44	EIF2S3	eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa	231	0.94
chr12_9912992_9913534	0.44	CD69	CD69 molecule	234	0.92
chr10_17548651_17548924	0.44	ST8SIA6	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	52458	0.13
chr13_46755198_46755455	0.43	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	1133	0.45
chr14_100547439_100547590	0.43	CTD-2376I20.1		6299	0.15
chr14_78083458_78083619	0.43	SPTLC2	serine palmitoyltransferase, long chain base subunit 2	422	0.85
chr17_37933702_37934037	0.43	IKZF3	IKAROS family zinc finger 3 (Aiolos)	609	0.66
chr14_94596078_94596470	0.43	IFI27L2	interferon, alpha-inducible protein 27-like 2	273	0.89
chr3_2134255_2134406	0.43	ENSG00000223040	.	3435	0.31
chr5_119523820_119523971	0.42	ENSG00000251975	.	149453	0.05
chr7_7287223_7287567	0.42	C1GALT1	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1	13444	0.24
chr6_37484799_37485050	0.42	CCDC167	coiled-coil domain containing 167	17226	0.19
chr20_43597121_43597440	0.42	STK4	serine/threonine kinase 4	2113	0.25
chrX_13103844_13104411	0.42	FAM9C	family with sequence similarity 9, member C	41326	0.19
chrX_123011919_123012080	0.42	ENSG00000252627	.	3690	0.19
chr17_29647712_29648226	0.42	EVI2A	ecotropic viral integration site 2A	81	0.95
chr4_144326518_144326669	0.42	GAB1	GRB2-associated binding protein 1	13930	0.23
chr2_161995560_161995711	0.42	TANK	TRAF family member-associated NFKB activator	2169	0.37
chr6_9481959_9482110	0.41	OFCC1	orofacial cleft 1 candidate 1	451466	0.01
chrX_88218836_88218987	0.41	CPXCR1	CPX chromosome region, candidate 1	216675	0.02
chr2_32287857_32288084	0.41	SPAST	spastin	710	0.64
chr4_41884194_41884831	0.41	TMEM33	transmembrane protein 33	52625	0.14
chr8_8727017_8727210	0.41	MFHAS1	malignant fibrous histiocytoma amplified sequence 1	24042	0.18
chr4_38857647_38857807	0.41	TLR6	toll-like receptor 6	710	0.4
chr3_112693608_112694254	0.41	CD200R1	CD200 receptor 1	6	0.97
chr5_118607055_118607314	0.41	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	2735	0.27
chr5_73730259_73730491	0.40	ENSG00000244326	.	116564	0.06
chr18_13275446_13275597	0.40	LDLRAD4	low density lipoprotein receptor class A domain containing 4	2581	0.29
chr14_71454929_71455080	0.40	PCNX	pecanex homolog (Drosophila)	24744	0.26
chr12_27472599_27472750	0.40	ARNTL2	aryl hydrocarbon receptor nuclear translocator-like 2	13113	0.22

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ALX1_ARX

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.9	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.2	1.0	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.2	0.5	GO:0010761	fibroblast migration(GO:0010761)
0.2	0.5	GO:0070340	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.2	0.5	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.2	0.5	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.1	0.4	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.1	0.7	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.1	0.4	GO:0042118	endothelial cell activation(GO:0042118)
0.1	0.5	GO:0035608	protein deglutamylation(GO:0035608)
0.1	0.4	GO:0048631	regulation of skeletal muscle tissue growth(GO:0048631)
0.1	1.3	GO:0006911	phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.1	0.4	GO:0010447	response to acidic pH(GO:0010447)
0.1	0.3	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1	0.4	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.1	0.5	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.1	0.6	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1	0.3	GO:0035455	response to interferon-alpha(GO:0035455)
0.1	0.3	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1	1.2	GO:0043550	regulation of lipid kinase activity(GO:0043550)
0.1	0.4	GO:0042789	mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.1	0.3	GO:0006667	sphinganine metabolic process(GO:0006667)
0.1	0.3	GO:1900120	regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.1	0.3	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.1	0.4	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.1	0.5	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.1	0.9	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1	0.3	GO:0070272	proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.1	0.1	GO:0050434	positive regulation of viral transcription(GO:0050434)
0.1	0.6	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.1	0.4	GO:0034214	protein hexamerization(GO:0034214)
0.1	0.2	GO:0006154	adenosine catabolic process(GO:0006154)
0.1	0.2	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.1	0.3	GO:1904035	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.1	0.2	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.1	0.4	GO:0030174	regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.1	0.1	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.1	0.3	GO:0045059	positive thymic T cell selection(GO:0045059)
0.1	0.6	GO:0050860	regulation of T cell receptor signaling pathway(GO:0050856) negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1	1.6	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.1	0.1	GO:0071481	cellular response to X-ray(GO:0071481)
0.1	1.6	GO:0070303	negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.1	0.6	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.1	0.6	GO:0000085	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.1	0.3	GO:0043383	negative T cell selection(GO:0043383)
0.1	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1	0.2	GO:0030644	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.1	0.7	GO:0030260	entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.1	0.9	GO:0016578	histone deubiquitination(GO:0016578)
0.1	0.2	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.1	0.2	GO:0045588	regulation of gamma-delta T cell differentiation(GO:0045586) positive regulation of gamma-delta T cell differentiation(GO:0045588) regulation of gamma-delta T cell activation(GO:0046643) positive regulation of gamma-delta T cell activation(GO:0046645)
0.1	0.1	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.1	0.5	GO:0007172	signal complex assembly(GO:0007172)
0.1	0.1	GO:0070932	histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.1	0.2	GO:0051541	elastin metabolic process(GO:0051541)
0.1	0.1	GO:0042109	lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.1	0.6	GO:0043968	histone H2A acetylation(GO:0043968)
0.1	0.2	GO:0019060	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.1	0.2	GO:0001821	histamine secretion(GO:0001821)
0.1	0.2	GO:0002483	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1	2.8	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.0	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0	0.7	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.2	GO:0000380	alternative mRNA splicing, via spliceosome(GO:0000380)
0.0	0.4	GO:0010165	response to X-ray(GO:0010165)
0.0	0.1	GO:0042663	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.2	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.0	0.1	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.2	GO:0044314	protein K27-linked ubiquitination(GO:0044314)
0.0	0.1	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0	0.0	GO:0090312	regulation of protein deacetylation(GO:0090311) positive regulation of protein deacetylation(GO:0090312)
0.0	0.4	GO:0070536	protein K63-linked deubiquitination(GO:0070536)
0.0	0.1	GO:0070295	renal water absorption(GO:0070295)
0.0	0.1	GO:0033622	integrin activation(GO:0033622)
0.0	0.2	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0032897	negative regulation of viral transcription(GO:0032897)
0.0	0.1	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.1	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	1.1	GO:0031295	lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0	0.3	GO:0006030	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.4	GO:0090114	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0	0.1	GO:0051927	obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051927)
0.0	0.1	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.0	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.3	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0	0.7	GO:0043484	regulation of RNA splicing(GO:0043484)
0.0	0.3	GO:0015671	oxygen transport(GO:0015671)
0.0	0.1	GO:1901419	regulation of response to alcohol(GO:1901419)
0.0	0.1	GO:0072526	pyridine-containing compound catabolic process(GO:0072526)
0.0	0.1	GO:0019348	polyprenol metabolic process(GO:0016093) dolichol metabolic process(GO:0019348)
0.0	0.2	GO:0060768	regulation of epithelial cell proliferation involved in prostate gland development(GO:0060768)
0.0	0.1	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.2	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.5	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.1	GO:0019530	taurine metabolic process(GO:0019530)
0.0	0.3	GO:0050710	negative regulation of cytokine secretion(GO:0050710)
0.0	0.1	GO:0018206	peptidyl-methionine modification(GO:0018206)
0.0	0.1	GO:0010626	regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626)
0.0	0.3	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.0	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.8	GO:0000245	spliceosomal complex assembly(GO:0000245)
0.0	0.1	GO:0006772	thiamine metabolic process(GO:0006772)
0.0	0.1	GO:0044380	protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0	0.3	GO:0007020	microtubule nucleation(GO:0007020)
0.0	0.1	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.1	GO:0051531	NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0	0.1	GO:0032212	positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0	0.1	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.1	GO:0032543	mitochondrial translation(GO:0032543)
0.0	0.1	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.2	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.4	GO:0051568	histone H3-K4 methylation(GO:0051568)
0.0	0.1	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.1	GO:0006378	mRNA polyadenylation(GO:0006378)
0.0	0.1	GO:0072133	kidney mesenchyme morphogenesis(GO:0072131) metanephric mesenchyme morphogenesis(GO:0072133)
0.0	0.1	GO:0060766	negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0	0.6	GO:0019933	cAMP-mediated signaling(GO:0019933)
0.0	0.5	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0	0.1	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.1	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.1	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.2	GO:0006878	cellular copper ion homeostasis(GO:0006878)
0.0	0.3	GO:0035964	COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0	0.2	GO:0034382	chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830)
0.0	0.1	GO:0046502	uroporphyrinogen III metabolic process(GO:0046502)
0.0	0.4	GO:0060334	regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.1	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.1	GO:0010592	positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0	0.0	GO:0051096	positive regulation of helicase activity(GO:0051096)
0.0	0.1	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.0	GO:0014742	positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.1	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein(GO:0042532)
0.0	0.2	GO:0070570	regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0	0.4	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0	0.1	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.1	GO:0045329	amino-acid betaine biosynthetic process(GO:0006578) carnitine biosynthetic process(GO:0045329)
0.0	0.1	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.0	0.1	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.1	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.0	0.1	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.1	GO:0071158	positive regulation of cell cycle arrest(GO:0071158)
0.0	0.1	GO:0034629	cellular protein complex localization(GO:0034629)
0.0	0.2	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.1	GO:0031573	intra-S DNA damage checkpoint(GO:0031573)
0.0	0.2	GO:0047497	establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.8	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0	0.2	GO:0006303	double-strand break repair via nonhomologous end joining(GO:0006303)
0.0	0.1	GO:0046476	glycosylceramide biosynthetic process(GO:0046476)
0.0	0.1	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0	0.1	GO:0046856	phosphatidylinositol dephosphorylation(GO:0046856)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.0	GO:0051665	membrane raft localization(GO:0051665)
0.0	0.1	GO:0016559	peroxisome fission(GO:0016559)
0.0	0.0	GO:0045056	transcytosis(GO:0045056)
0.0	0.2	GO:0045116	protein neddylation(GO:0045116)
0.0	0.1	GO:0042159	lipoprotein catabolic process(GO:0042159)
0.0	0.1	GO:0045349	interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.2	GO:0045648	positive regulation of erythrocyte differentiation(GO:0045648)
0.0	0.0	GO:0019935	cyclic-nucleotide-mediated signaling(GO:0019935)
0.0	0.0	GO:0032922	circadian regulation of gene expression(GO:0032922)
0.0	0.1	GO:0061365	positive regulation of lipoprotein lipase activity(GO:0051006) positive regulation of triglyceride lipase activity(GO:0061365)
0.0	3.0	GO:0006333	chromatin assembly or disassembly(GO:0006333)
0.0	0.1	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.0	0.0	GO:0048291	isotype switching to IgG isotypes(GO:0048291)
0.0	0.1	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.2	GO:0036230	granulocyte activation(GO:0036230)
0.0	0.1	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.1	GO:1901998	antibiotic transport(GO:0042891) toxin transport(GO:1901998)
0.0	0.0	GO:0045723	positive regulation of fatty acid biosynthetic process(GO:0045723)
0.0	0.1	GO:0060972	left/right pattern formation(GO:0060972)
0.0	0.0	GO:0000089	mitotic metaphase(GO:0000089)
0.0	0.0	GO:0002478	antigen processing and presentation of exogenous peptide antigen(GO:0002478)
0.0	0.1	GO:0046548	retinal rod cell development(GO:0046548)
0.0	0.2	GO:0042992	negative regulation of transcription factor import into nucleus(GO:0042992)
0.0	0.3	GO:0002286	T cell activation involved in immune response(GO:0002286)
0.0	0.0	GO:0060413	atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0	0.0	GO:0031062	positive regulation of histone methylation(GO:0031062)
0.0	0.1	GO:0006551	leucine metabolic process(GO:0006551)
0.0	0.2	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.1	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.1	GO:0071168	protein localization to chromatin(GO:0071168)
0.0	0.1	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.1	GO:0042447	hormone catabolic process(GO:0042447)
0.0	0.1	GO:0030952	establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.0	0.0	GO:0007144	female meiosis I(GO:0007144)
0.0	0.1	GO:0009249	protein lipoylation(GO:0009249)
0.0	0.3	GO:0007339	binding of sperm to zona pellucida(GO:0007339)
0.0	0.1	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0	0.2	GO:0075733	multi-organism transport(GO:0044766) transport of virus(GO:0046794) intracellular transport of virus(GO:0075733) multi-organism localization(GO:1902579) multi-organism intracellular transport(GO:1902583)
0.0	0.0	GO:0014889	muscle atrophy(GO:0014889)
0.0	0.4	GO:0032480	negative regulation of type I interferon production(GO:0032480)
0.0	0.1	GO:0038061	activation of NF-kappaB-inducing kinase activity(GO:0007250) NIK/NF-kappaB signaling(GO:0038061) regulation of NIK/NF-kappaB signaling(GO:1901222) positive regulation of NIK/NF-kappaB signaling(GO:1901224)
0.0	0.0	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.2	GO:0045123	cellular extravasation(GO:0045123)
0.0	0.3	GO:1901661	quinone metabolic process(GO:1901661)
0.0	0.0	GO:0050667	homocysteine metabolic process(GO:0050667)
0.0	0.1	GO:0009151	purine deoxyribonucleotide metabolic process(GO:0009151)
0.0	0.1	GO:0048069	eye pigmentation(GO:0048069)
0.0	0.2	GO:0000018	regulation of DNA recombination(GO:0000018)
0.0	0.1	GO:0008653	lipopolysaccharide metabolic process(GO:0008653)
0.0	0.1	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.1	GO:0036465	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.1	GO:0071034	CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0	0.1	GO:0035305	negative regulation of dephosphorylation(GO:0035305) negative regulation of protein dephosphorylation(GO:0035308)
0.0	0.1	GO:0003084	positive regulation of systemic arterial blood pressure(GO:0003084)
0.0	0.1	GO:0030187	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.5	GO:0016579	protein deubiquitination(GO:0016579)
0.0	0.0	GO:0070646	protein modification by small protein removal(GO:0070646)
0.0	0.1	GO:0000183	chromatin silencing at rDNA(GO:0000183)
0.0	0.1	GO:0016572	histone phosphorylation(GO:0016572)
0.0	0.1	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.0	0.3	GO:0051225	spindle assembly(GO:0051225)
0.0	0.0	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0	0.0	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.1	GO:0033522	histone H2A ubiquitination(GO:0033522)
0.0	0.1	GO:0000098	sulfur amino acid catabolic process(GO:0000098)
0.0	0.1	GO:0006983	ER overload response(GO:0006983)
0.0	0.1	GO:0021591	ventricular system development(GO:0021591)
0.0	0.1	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.1	GO:0060081	membrane hyperpolarization(GO:0060081)
0.0	0.2	GO:0097191	extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) extrinsic apoptotic signaling pathway(GO:0097191)
0.0	0.2	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.0	0.1	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.1	GO:0031648	protein destabilization(GO:0031648)
0.0	0.0	GO:0033088	regulation of immature T cell proliferation(GO:0033083) regulation of immature T cell proliferation in thymus(GO:0033084) negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0	0.1	GO:0010523	negative regulation of calcium ion transport into cytosol(GO:0010523)
0.0	0.2	GO:0015939	pantothenate metabolic process(GO:0015939)
0.0	0.1	GO:0033523	histone H2B ubiquitination(GO:0033523)
0.0	0.3	GO:0070936	protein K48-linked ubiquitination(GO:0070936)
0.0	0.0	GO:0002540	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.1	GO:0006534	cysteine metabolic process(GO:0006534)
0.0	0.3	GO:0015949	nucleobase-containing small molecule interconversion(GO:0015949)
0.0	0.0	GO:0032908	transforming growth factor beta1 production(GO:0032905) regulation of transforming growth factor beta1 production(GO:0032908)
0.0	0.2	GO:0071044	histone mRNA catabolic process(GO:0071044)
0.0	0.1	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0	0.1	GO:0045793	positive regulation of cell size(GO:0045793)
0.0	0.9	GO:1902807	negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0	0.0	GO:0009186	deoxyribonucleoside diphosphate metabolic process(GO:0009186) deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0	0.0	GO:0032785	negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0	0.0	GO:2001234	negative regulation of mitochondrion organization(GO:0010823) negative regulation of release of cytochrome c from mitochondria(GO:0090201) negative regulation of apoptotic signaling pathway(GO:2001234)
0.0	0.5	GO:0006368	transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0	0.0	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	1.5	GO:0007565	female pregnancy(GO:0007565)
0.0	0.1	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.0	0.1	GO:0008608	attachment of spindle microtubules to kinetochore(GO:0008608)
0.0	0.1	GO:0000730	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.1	GO:0046519	sphingoid metabolic process(GO:0046519)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.1	GO:0034587	piRNA metabolic process(GO:0034587)
0.0	0.1	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.0	GO:0052251	induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251)
0.0	0.0	GO:0050857	positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0	0.4	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059) negative regulation of ERBB signaling pathway(GO:1901185)
0.0	0.1	GO:1904031	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0	0.0	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0006521	regulation of cellular amino acid metabolic process(GO:0006521)
0.0	0.1	GO:0033146	regulation of intracellular estrogen receptor signaling pathway(GO:0033146)
0.0	0.0	GO:0018343	protein farnesylation(GO:0018343)
0.0	0.1	GO:0051597	response to methylmercury(GO:0051597)
0.0	0.0	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.0	0.0	GO:0048935	peripheral nervous system neuron development(GO:0048935)
0.0	0.0	GO:0006346	methylation-dependent chromatin silencing(GO:0006346)
0.0	0.1	GO:0043248	proteasome assembly(GO:0043248)
0.0	0.1	GO:0098927	early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0	0.0	GO:0000733	DNA strand renaturation(GO:0000733)
0.0	0.0	GO:0032071	regulation of endodeoxyribonuclease activity(GO:0032071)
0.0	0.0	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.8	GO:0006413	translational initiation(GO:0006413)
0.0	0.1	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0	0.0	GO:0010533	regulation of activation of Janus kinase activity(GO:0010533) positive regulation of activation of Janus kinase activity(GO:0010536)
0.0	0.1	GO:0046500	S-adenosylmethionine metabolic process(GO:0046500)
0.0	2.3	GO:0016568	chromatin modification(GO:0016568)
0.0	0.0	GO:0007063	regulation of sister chromatid cohesion(GO:0007063)
0.0	0.0	GO:0031646	positive regulation of neurological system process(GO:0031646)
0.0	0.2	GO:0051865	protein autoubiquitination(GO:0051865)
0.0	0.0	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.0	GO:0007000	nucleolus organization(GO:0007000)
0.0	0.1	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0	0.4	GO:0006888	ER to Golgi vesicle-mediated transport(GO:0006888)
0.0	0.0	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.1	GO:0040001	establishment of mitotic spindle localization(GO:0040001)
0.0	0.0	GO:0007064	mitotic sister chromatid cohesion(GO:0007064)
0.0	0.0	GO:0045618	positive regulation of keratinocyte differentiation(GO:0045618)
0.0	0.0	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.1	GO:0043666	regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0	0.0	GO:0019883	antigen processing and presentation of endogenous antigen(GO:0019883)
0.0	0.0	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.0	GO:0030889	negative regulation of B cell proliferation(GO:0030889)
0.0	0.1	GO:0042769	DNA damage response, detection of DNA damage(GO:0042769)
0.0	0.0	GO:0034625	fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0	0.3	GO:0060333	interferon-gamma-mediated signaling pathway(GO:0060333)
0.0	0.1	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0	0.1	GO:0006020	inositol metabolic process(GO:0006020)
0.0	0.0	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.0	0.1	GO:0071941	nitrogen cycle metabolic process(GO:0071941)
0.0	0.0	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.0	GO:0006379	mRNA cleavage(GO:0006379)
0.0	0.1	GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0	0.0	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.0	GO:0042832	defense response to protozoan(GO:0042832)
0.0	0.1	GO:0020027	hemoglobin metabolic process(GO:0020027)
0.0	0.0	GO:0031282	regulation of guanylate cyclase activity(GO:0031282)
0.0	0.3	GO:0072512	ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.0	0.1	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0	0.0	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.1	GO:0033962	cytoplasmic mRNA processing body assembly(GO:0033962)
0.0	0.1	GO:0008634	obsolete negative regulation of survival gene product expression(GO:0008634)
0.0	0.2	GO:0000291	nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0	0.1	GO:0031115	negative regulation of microtubule polymerization(GO:0031115)
0.0	0.0	GO:0046541	saliva secretion(GO:0046541)
0.0	0.0	GO:0009134	nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.0	1.6	GO:0000375	RNA splicing, via transesterification reactions(GO:0000375)
0.0	0.0	GO:0060456	positive regulation of digestive system process(GO:0060456)
0.0	0.1	GO:0035020	regulation of Rac protein signal transduction(GO:0035020)
0.0	0.0	GO:0032527	protein exit from endoplasmic reticulum(GO:0032527)
0.0	0.0	GO:0009301	snRNA transcription(GO:0009301)
0.0	0.0	GO:0006434	seryl-tRNA aminoacylation(GO:0006434)
0.0	0.0	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.0	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.1	GO:0060017	parathyroid gland development(GO:0060017)
0.0	0.2	GO:0036503	ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) ERAD pathway(GO:0036503)
0.0	0.7	GO:0018279	peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.0	0.2	GO:0015804	neutral amino acid transport(GO:0015804)
0.0	0.0	GO:0097501	detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0	0.3	GO:0000186	activation of MAPKK activity(GO:0000186)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	0.3	GO:0042629	mast cell granule(GO:0042629)
0.1	0.3	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1	0.8	GO:0001891	phagocytic cup(GO:0001891)
0.1	0.4	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1	0.3	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	0.3	GO:0002178	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1	0.4	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.1	0.3	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.1	0.9	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.1	0.1	GO:0001740	Barr body(GO:0001740)
0.1	0.1	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.1	0.4	GO:0000125	PCAF complex(GO:0000125)
0.1	0.5	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.1	0.2	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.1	0.6	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.1	0.4	GO:0070822	Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822)
0.1	0.4	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.2	GO:0005719	nuclear euchromatin(GO:0005719)
0.0	0.2	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0	0.2	GO:0030870	Mre11 complex(GO:0030870)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.4	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.2	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.6	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.2	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.1	GO:0030891	VCB complex(GO:0030891)
0.0	0.2	GO:0042827	platelet dense granule(GO:0042827)
0.0	0.2	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.4	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.3	GO:0061200	clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0	0.6	GO:0032592	integral component of mitochondrial membrane(GO:0032592)
0.0	0.3	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.7	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.3	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.0	0.1	GO:0070062	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.2	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.4	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.1	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.2	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	0.2	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.2	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.1	GO:0030904	retromer complex(GO:0030904)
0.0	0.2	GO:0000145	exocyst(GO:0000145)
0.0	0.0	GO:0000791	euchromatin(GO:0000791)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.3	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.2	GO:0032040	small-subunit processome(GO:0032040)
0.0	0.1	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.3	GO:0043209	myelin sheath(GO:0043209)
0.0	0.0	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.9	GO:0000118	histone deacetylase complex(GO:0000118)
0.0	0.1	GO:0043159	acrosomal matrix(GO:0043159)
0.0	0.6	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	0.3	GO:0005657	replication fork(GO:0005657)
0.0	0.1	GO:0000444	MIS12/MIND type complex(GO:0000444)
0.0	3.1	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.1	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.1	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.0	1.4	GO:0000786	nucleosome(GO:0000786)
0.0	0.1	GO:0000346	transcription export complex(GO:0000346)
0.0	0.2	GO:0042598	obsolete vesicular fraction(GO:0042598)
0.0	0.1	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.0	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.0	0.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.5	GO:0005689	U12-type spliceosomal complex(GO:0005689)
0.0	0.1	GO:0010369	chromocenter(GO:0010369)
0.0	0.2	GO:0016585	obsolete chromatin remodeling complex(GO:0016585)
0.0	2.7	GO:0000785	chromatin(GO:0000785)
0.0	0.2	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0	0.1	GO:0070552	BRISC complex(GO:0070552)
0.0	0.7	GO:0030175	filopodium(GO:0030175)
0.0	3.7	GO:0016604	nuclear body(GO:0016604)
0.0	0.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.1	GO:0045275	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0	0.4	GO:0097610	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0	0.1	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.1	GO:0000780	condensed nuclear chromosome, centromeric region(GO:0000780)
0.0	0.0	GO:0032449	CBM complex(GO:0032449)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.1	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.1	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.1	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.4	GO:0032993	protein-DNA complex(GO:0032993)
0.0	0.1	GO:0043202	lysosomal lumen(GO:0043202)
0.0	0.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.0	GO:0000153	cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0	0.1	GO:0043073	germ cell nucleus(GO:0043073)
0.0	0.2	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.1	GO:0008278	cohesin complex(GO:0008278)
0.0	0.2	GO:0030126	COPI vesicle coat(GO:0030126)
0.0	0.1	GO:0017071	intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0	0.1	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	2.0	GO:0005769	early endosome(GO:0005769)
0.0	0.3	GO:0005763	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0	0.0	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.0	0.7	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
0.0	0.0	GO:0044453	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.0	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.2	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0	0.1	GO:0001772	immunological synapse(GO:0001772)
0.0	0.1	GO:0033276	transcription factor TFTC complex(GO:0033276)
0.0	0.0	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.0	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	0.2	GO:0005844	polysome(GO:0005844)
0.0	0.1	GO:0000178	exosome (RNase complex)(GO:0000178)
0.0	0.1	GO:0017119	Golgi transport complex(GO:0017119)
0.0	0.1	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	0.2	GO:0030530	obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0	0.0	GO:0030663	COPI-coated vesicle membrane(GO:0030663)
0.0	2.9	GO:0005768	endosome(GO:0005768)
0.0	0.0	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.0	0.1	GO:0005786	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.1	GO:0045179	apical cortex(GO:0045179)
0.0	0.2	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.0	0.0	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.4	GO:0016363	nuclear matrix(GO:0016363)
0.0	0.0	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.1	GO:0005869	dynactin complex(GO:0005869)
0.0	0.1	GO:0034399	nuclear periphery(GO:0034399)
0.0	0.1	GO:0000930	gamma-tubulin complex(GO:0000930)
0.0	0.1	GO:0043186	P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0	0.0	GO:0042587	glycogen granule(GO:0042587)
0.0	0.0	GO:0031501	mannosyltransferase complex(GO:0031501) dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0	0.1	GO:0005845	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	0.1	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.0	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.0	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.1	0.6	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1	0.3	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.1	1.3	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.1	0.3	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1	2.2	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1	0.6	GO:0001784	phosphotyrosine binding(GO:0001784)
0.1	0.3	GO:0071723	lipopeptide binding(GO:0071723)
0.1	0.4	GO:0001846	opsonin binding(GO:0001846)
0.1	0.5	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.1	0.5	GO:0070513	death domain binding(GO:0070513)
0.1	0.3	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.1	0.3	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1	0.6	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.1	0.3	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.1	0.5	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1	0.2	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.1	0.2	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1	0.3	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.1	0.4	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.1	0.3	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1	0.3	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.1	0.2	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.1	0.2	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1	0.2	GO:0098847	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.1	0.2	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.1	0.2	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.1	0.5	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.1	1.0	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1	0.2	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.1	1.9	GO:0004177	aminopeptidase activity(GO:0004177)
0.1	0.2	GO:0031685	adenosine receptor binding(GO:0031685)
0.1	0.2	GO:0045569	TRAIL binding(GO:0045569)
0.1	0.2	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.1	0.4	GO:0005522	profilin binding(GO:0005522)
0.1	2.0	GO:0004860	protein kinase inhibitor activity(GO:0004860)
0.0	0.2	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.3	GO:0061630	ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0	0.2	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.2	GO:0016531	copper chaperone activity(GO:0016531)
0.0	0.3	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.1	GO:0015254	glycerol channel activity(GO:0015254)
0.0	0.2	GO:0003960	NADPH:quinone reductase activity(GO:0003960)
0.0	0.0	GO:0032137	guanine/thymine mispair binding(GO:0032137)
0.0	1.4	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.0	0.4	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.1	GO:0030548	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0	0.3	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.6	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.1	GO:0034056	estrogen response element binding(GO:0034056)
0.0	1.2	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.3	GO:0004568	chitinase activity(GO:0004568)
0.0	0.2	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.1	GO:0070215	obsolete MDM2 binding(GO:0070215)
0.0	0.2	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.3	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.2	GO:0016778	diphosphotransferase activity(GO:0016778)
0.0	0.1	GO:0008384	IkappaB kinase activity(GO:0008384)
0.0	0.2	GO:0004645	phosphorylase activity(GO:0004645)
0.0	0.2	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.0	GO:0000404	heteroduplex DNA loop binding(GO:0000404)
0.0	0.1	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.1	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.3	GO:0004437	obsolete inositol or phosphatidylinositol phosphatase activity(GO:0004437)
0.0	0.1	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.1	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.5	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.3	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.1	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	0.6	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.3	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.4	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	1.7	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.4	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.6	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.2	GO:0016565	obsolete general transcriptional repressor activity(GO:0016565)
0.0	0.1	GO:0043175	RNA polymerase core enzyme binding(GO:0043175)
0.0	0.0	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.2	GO:0034235	GPI anchor binding(GO:0034235)
0.0	0.2	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.2	GO:0051766	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.6	GO:0046966	thyroid hormone receptor binding(GO:0046966)
0.0	0.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.1	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.1	GO:0015520	tetracycline:proton antiporter activity(GO:0015520)
0.0	0.2	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.1	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.1	GO:0000832	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0	0.1	GO:0034481	chondroitin sulfotransferase activity(GO:0034481)
0.0	0.2	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.4	GO:0043014	alpha-tubulin binding(GO:0043014)
0.0	1.6	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	0.1	GO:0004775	succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0	0.1	GO:0015924	mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0	0.1	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.3	GO:0017025	TBP-class protein binding(GO:0017025)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.5	GO:0004890	GABA-A receptor activity(GO:0004890)
0.0	0.2	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.4	GO:0043499	obsolete eukaryotic cell surface binding(GO:0043499)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.1	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.8	GO:0017048	Rho GTPase binding(GO:0017048)
0.0	0.1	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.0	0.1	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0004517	nitric-oxide synthase activity(GO:0004517)
0.0	0.1	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.7	GO:0008094	DNA-dependent ATPase activity(GO:0008094)
0.0	0.1	GO:0031013	troponin I binding(GO:0031013)
0.0	0.1	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.3	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.0	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.1	GO:0015211	purine nucleoside transmembrane transporter activity(GO:0015211)
0.0	0.2	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0	0.1	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.5	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.0	0.1	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.1	GO:0016681	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0	0.1	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.1	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.3	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.1	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0044620	ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process(GO:0000036) ACP phosphopantetheine attachment site binding(GO:0044620) prosthetic group binding(GO:0051192)
0.0	0.1	GO:0042288	MHC class I protein binding(GO:0042288)
0.0	0.2	GO:0008409	5'-3' exonuclease activity(GO:0008409)
0.0	0.1	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.0	0.1	GO:0032450	maltose alpha-glucosidase activity(GO:0032450)
0.0	0.1	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.0	0.1	GO:0004739	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.1	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.1	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.9	GO:0008301	DNA binding, bending(GO:0008301)
0.0	0.1	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.1	GO:0016805	dipeptidase activity(GO:0016805)
0.0	0.8	GO:0003743	translation initiation factor activity(GO:0003743)
0.0	0.2	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.0	0.1	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.0	0.1	GO:0008649	rRNA methyltransferase activity(GO:0008649)
0.0	0.1	GO:0003678	DNA helicase activity(GO:0003678)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.1	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.0	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.1	GO:0030507	spectrin binding(GO:0030507)
0.0	0.0	GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	0.2	GO:0015605	organophosphate ester transmembrane transporter activity(GO:0015605)
0.0	0.0	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.8	GO:0004221	obsolete ubiquitin thiolesterase activity(GO:0004221)
0.0	0.0	GO:0016530	metallochaperone activity(GO:0016530)
0.0	0.3	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.0	0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.2	GO:0003711	obsolete transcription elongation regulator activity(GO:0003711)
0.0	0.0	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.0	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.2	GO:0004806	triglyceride lipase activity(GO:0004806)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.0	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.0	GO:0008312	7S RNA binding(GO:0008312)
0.0	0.4	GO:0019003	GDP binding(GO:0019003)
0.0	0.3	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.0	0.1	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.1	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.1	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.1	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.1	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	0.1	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.2	GO:0048487	beta-tubulin binding(GO:0048487)
0.0	0.2	GO:0008320	protein transmembrane transporter activity(GO:0008320)
0.0	0.1	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.0	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.3	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0	0.0	GO:0008235	metalloexopeptidase activity(GO:0008235)
0.0	0.2	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.0	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.1	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	0.1	GO:0005283	sodium:amino acid symporter activity(GO:0005283)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.1	GO:0005048	signal sequence binding(GO:0005048)
0.0	0.0	GO:0034584	piRNA binding(GO:0034584)
0.0	0.1	GO:0031369	translation initiation factor binding(GO:0031369)
0.0	0.1	GO:0008172	S-methyltransferase activity(GO:0008172)
0.0	0.1	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.0	GO:0031849	olfactory receptor binding(GO:0031849)
0.0	0.0	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.0	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.1	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.0	GO:0031491	nucleosome binding(GO:0031491)
0.0	0.0	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.0	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.0	0.6	GO:0042393	histone binding(GO:0042393)
0.0	0.0	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.1	GO:0051920	peroxiredoxin activity(GO:0051920)
0.0	0.0	GO:0003896	DNA primase activity(GO:0003896)
0.0	0.0	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.2	GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896)
0.0	0.2	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
0.0	0.3	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.1	GO:0017069	snRNA binding(GO:0017069)
0.0	0.0	GO:0030235	nitric-oxide synthase regulator activity(GO:0030235)
0.0	0.0	GO:0004559	alpha-mannosidase activity(GO:0004559)
0.0	0.1	GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.0	0.0	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0	0.3	GO:0003823	antigen binding(GO:0003823)
0.0	0.1	GO:0010181	FMN binding(GO:0010181)
0.0	0.1	GO:0008171	O-methyltransferase activity(GO:0008171)
0.0	0.1	GO:0003756	protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0	0.2	GO:0008186	RNA-dependent ATPase activity(GO:0008186)
0.0	0.0	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.0	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.1	GO:0043855	intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0	0.0	GO:0004828	serine-tRNA ligase activity(GO:0004828)
0.0	0.1	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.3	GO:0016860	intramolecular oxidoreductase activity(GO:0016860)
0.0	0.0	GO:0000400	four-way junction DNA binding(GO:0000400)
0.0	0.0	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.0	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.1	GO:0016251	obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.0	0.0	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.0	0.1	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0	0.5	GO:0008026	ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.0	0.0	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0	0.2	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.0	0.1	GO:0004303	estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0	0.1	GO:0008373	sialyltransferase activity(GO:0008373)
0.0	0.0	GO:0004301	epoxide hydrolase activity(GO:0004301)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.5	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	2.1	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.1	1.8	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.1	0.7	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1	0.9	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.1	3.2	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.1	1.2	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.1	1.6	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.1	1.7	PID FOXO PATHWAY	FoxO family signaling
0.0	1.2	PID IL2 1PATHWAY	IL2-mediated signaling events
0.0	0.1	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.6	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	0.7	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.8	PID IL3 PATHWAY	IL3-mediated signaling events
0.0	0.4	PID EPO PATHWAY	EPO signaling pathway
0.0	0.4	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.4	PID TRAIL PATHWAY	TRAIL signaling pathway
0.0	0.7	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	0.6	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0	1.5	PID CXCR4 PATHWAY	CXCR4-mediated signaling events
0.0	0.3	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	0.9	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	1.2	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	0.2	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	0.6	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	0.1	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	0.7	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	0.4	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.0	0.1	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis
0.0	0.1	PID ENDOTHELIN PATHWAY	Endothelins
0.0	0.1	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.0	0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	0.1	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	0.1	PID IGF1 PATHWAY	IGF1 pathway
0.0	0.0	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.1	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	0.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	0.2	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.3	PID IL12 2PATHWAY	IL12-mediated signaling events
0.0	0.5	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.0	0.2	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.0	0.2	PID BCR 5PATHWAY	BCR signaling pathway
0.0	0.3	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.0	0.1	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	0.2	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.0	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.2	PID INSULIN PATHWAY	Insulin Pathway
0.0	0.4	PID ATM PATHWAY	ATM pathway
0.0	0.2	PID ALK1 PATHWAY	ALK1 signaling events
0.0	0.2	PID RAS PATHWAY	Regulation of Ras family activation
0.0	0.1	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.0	0.1	PID AURORA A PATHWAY	Aurora A signaling
0.0	0.0	PID BARD1 PATHWAY	BARD1 signaling events
0.0	0.3	PID PLK1 PATHWAY	PLK1 signaling events
0.0	0.1	ST B CELL ANTIGEN RECEPTOR	B Cell Antigen Receptor

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.6	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.2	0.6	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.1	1.4	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	0.6	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.1	0.1	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1	1.0	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.1	0.1	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1	0.6	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1	2.8	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.1	1.0	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.1	0.2	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1	0.9	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	1.4	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.3	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	1.2	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.5	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.5	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.3	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.9	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	0.5	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.3	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
0.0	0.6	REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN	Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0	0.5	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.6	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.0	0.9	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.0	0.1	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0	0.2	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	0.3	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.0	0.4	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	0.5	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.4	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	1.2	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	1.0	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.0	0.0	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.1	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.0	0.4	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.0	0.3	REACTOME INTERFERON SIGNALING	Genes involved in Interferon Signaling
0.0	0.4	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	0.4	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.2	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	1.5	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.3	REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	Genes involved in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
0.0	0.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	0.6	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	0.0	REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.0	0.2	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.6	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.0	0.4	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.1	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	0.6	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
0.0	0.1	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.1	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.2	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.0	0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.2	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	2.3	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	0.3	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0	0.1	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	0.9	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.1	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	0.2	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.0	0.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	0.3	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.3	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.0	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	0.1	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.0	0.1	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.2	REACTOME RNA POL I TRANSCRIPTION	Genes involved in RNA Polymerase I Transcription
0.0	0.3	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.3	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.0	0.4	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	0.3	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.3	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.0	0.8	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.0	0.1	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0	0.3	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.3	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.3	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0	0.8	REACTOME METABOLISM OF NON CODING RNA	Genes involved in Metabolism of non-coding RNA
0.0	0.2	REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS	Genes involved in Post NMDA receptor activation events
0.0	0.7	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0	1.2	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.0	0.2	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4
0.0	0.0	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.0	0.1	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.1	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	0.0	REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.0	0.1	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells
0.0	0.1	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.0	0.0	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.0	0.0	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0	0.2	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.0	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0	0.1	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	0.3	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0	0.0	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0	0.5	REACTOME RNA POL II PRE TRANSCRIPTION EVENTS	Genes involved in RNA Polymerase II Pre-transcription Events
0.0	0.3	REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	Genes involved in Transport of Mature Transcript to Cytoplasm
0.0	0.6	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.0	0.3	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
0.0	0.0	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0	0.2	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0	0.7	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	0.1	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.0	0.0	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.0	0.1	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination

Results for ALX1_ARX

Z-value: 0.99

Motif logo

Transcription factors associated with ALX1_ARX

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the ALX1_ARX motif across conditions

Conditions sorted by the z-value of the ALX1_ARX motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ALX1_ARX

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: