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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ALX3

Z-value: 0.86

Motif logo

Transcription factors associated with ALX3

Gene Symbol	Gene ID	Gene Info
ALX3 Ensembl NCBI GeneCards UniProt	ENSG00000156150.6	ALX3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ALX3	chr1_110610926_110611170	2274	0.202908	0.68	4.4e-02	Click!
ALX3	chr1_110612851_110613002	396	0.780608	0.53	1.4e-01	Click!
ALX3	chr1_110610618_110610769	2629	0.183485	0.50	1.7e-01	Click!
ALX3	chr1_110611302_110611453	1945	0.229462	0.44	2.3e-01	Click!
ALX3	chr1_110611525_110611676	1722	0.254844	0.44	2.4e-01	Click!

Activity of the ALX3 motif across conditions

Conditions sorted by the z-value of the ALX3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr5_58055562_58056142	0.64	RP11-479O16.1		24754	0.24
chr7_123390243_123390394	0.58	RP11-390E23.6		1196	0.34
chr12_66583583_66583798	0.52	IRAK3	interleukin-1 receptor-associated kinase 3	653	0.67
chr6_130391698_130391967	0.51	L3MBTL3	l(3)mbt-like 3 (Drosophila)	50130	0.15
chr20_21080465_21081932	0.49	ENSG00000199509	.	38517	0.18
chr7_37724366_37724517	0.48	GPR141	G protein-coupled receptor 141	966	0.42
chr8_95941010_95941161	0.42	TP53INP1	tumor protein p53 inducible nuclear protein 1	12116	0.13
chr7_32929941_32930760	0.42	KBTBD2	kelch repeat and BTB (POZ) domain containing 2	415	0.87
chrX_78400540_78401325	0.39	GPR174	G protein-coupled receptor 174	25537	0.27
chr13_41555714_41555943	0.39	ELF1	E74-like factor 1 (ets domain transcription factor)	590	0.77
chr13_31309966_31310295	0.37	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	485	0.88
chr1_200865204_200865355	0.37	C1orf106	chromosome 1 open reading frame 106	1330	0.42
chr11_118134576_118134833	0.37	MPZL2	myelin protein zero-like 2	293	0.86
chr17_56362337_56362534	0.37	MPO	myeloperoxidase	4139	0.15
chr10_30745504_30745655	0.37	MAP3K8	mitogen-activated protein kinase kinase kinase 8	17828	0.21
chr21_15917916_15918619	0.37	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	395	0.89
chr5_126094279_126094440	0.36	ENSG00000252185	.	3250	0.29
chr4_147027155_147027306	0.36	ENSG00000216055	.	16206	0.24
chr4_40630076_40630227	0.36	RBM47	RNA binding motif protein 47	1730	0.47
chr4_36245078_36245884	0.36	ARAP2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	80	0.74
chr12_10019991_10020525	0.35	RP11-290C10.1		632	0.61
chr15_52844361_52844512	0.35	ARPP19	cAMP-regulated phosphoprotein, 19kDa	5505	0.2
chr2_103506378_103506656	0.35	TMEM182	transmembrane protein 182	128045	0.06
chr20_47448799_47448989	0.35	PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	4474	0.31
chr16_88987498_88987922	0.35	RP11-830F9.7		16454	0.11
chr8_56831708_56831859	0.35	ENSG00000216204	.	10263	0.14
chr2_70780238_70780449	0.34	TGFA	transforming growth factor, alpha	279	0.93
chr10_129861850_129862130	0.34	PTPRE	protein tyrosine phosphatase, receptor type, E	16156	0.26
chr1_8441651_8441802	0.34	RERE	arginine-glutamic acid dipeptide (RE) repeats	16828	0.17
chr6_133069776_133069927	0.34	RP1-55C23.7		3963	0.15
chr16_31271922_31272073	0.34	ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	682	0.53
chr22_40858929_40859404	0.34	MKL1	megakaryoblastic leukemia (translocation) 1	256	0.92
chr20_52271481_52272252	0.33	ENSG00000238468	.	13431	0.22
chr2_61111507_61111691	0.33	REL	v-rel avian reticuloendotheliosis viral oncogene homolog	2808	0.27
chr13_73631347_73631498	0.33	KLF5	Kruppel-like factor 5 (intestinal)	1508	0.47
chr1_234735009_234735261	0.32	ENSG00000212144	.	6114	0.19
chr12_10281805_10282201	0.32	CLEC7A	C-type lectin domain family 7, member A	678	0.6
chr12_27150397_27150548	0.32	TM7SF3	transmembrane 7 superfamily member 3	2271	0.24
chr3_187491387_187491633	0.32	BCL6	B-cell CLL/lymphoma 6	27995	0.2
chr5_68905149_68905341	0.32	RP11-848G14.2		8895	0.19
chr9_93557702_93558119	0.32	SYK	spleen tyrosine kinase	6159	0.34
chr5_67562966_67563283	0.32	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	12944	0.27
chr15_52023462_52024365	0.31	LYSMD2	LysM, putative peptidoglycan-binding, domain containing 2	6405	0.15
chr5_57787350_57787738	0.31	GAPT	GRB2-binding adaptor protein, transmembrane	280	0.92
chr15_69074948_69075145	0.31	ENSG00000265195	.	19218	0.22
chr4_105887659_105887892	0.31	ENSG00000251906	.	8044	0.31
chr11_128589269_128589524	0.31	SENCR	smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA	23478	0.17
chr14_75885513_75886422	0.31	RP11-293M10.6		8426	0.2
chr2_153267501_153267713	0.30	FMNL2	formin-like 2	75856	0.12
chr7_37726318_37726469	0.30	GPR141	G protein-coupled receptor 141	2918	0.28
chr21_39630264_39630415	0.30	KCNJ15	potassium inwardly-rectifying channel, subfamily J, member 15	1469	0.53
chr1_158802859_158803010	0.30	MNDA	myeloid cell nuclear differentiation antigen	1827	0.35
chr5_70314152_70314347	0.30	NAIP	NLR family, apoptosis inhibitory protein	2288	0.36
chr15_43531850_43532099	0.30	ENSG00000202211	.	7904	0.13
chr5_17282868_17283019	0.30	ENSG00000252908	.	42223	0.15
chr2_64864648_64864996	0.29	SERTAD2	SERTA domain containing 2	16225	0.22
chr2_70157637_70157788	0.29	MXD1	MAX dimerization protein 1	15392	0.11
chr12_8666250_8666401	0.29	CLEC4D	C-type lectin domain family 4, member D	189	0.93
chr10_12064652_12064803	0.29	UPF2	UPF2 regulator of nonsense transcripts homolog (yeast)	13169	0.19
chr11_33284734_33284885	0.29	HIPK3	homeodomain interacting protein kinase 3	4932	0.25
chr5_69760327_69760484	0.29	RP11-497H16.7		8870	0.28
chr7_115668295_115668446	0.29	TFEC	transcription factor EC	2425	0.43
chr7_105912156_105912307	0.29	NAMPT	nicotinamide phosphoribosyltransferase	13136	0.21
chr9_77757026_77757296	0.29	ENSG00000200041	.	39376	0.14
chr11_640631_640896	0.29	DRD4	dopamine receptor D4	3470	0.1
chr2_202076992_202077403	0.29	CASP8	caspase 8, apoptosis-related cysteine peptidase	20969	0.15
chr2_158299843_158300108	0.29	CYTIP	cytohesin 1 interacting protein	679	0.68
chr3_98480702_98481101	0.29	ST3GAL6	ST3 beta-galactoside alpha-2,3-sialyltransferase 6	1260	0.48
chr1_112013416_112013602	0.28	C1orf162	chromosome 1 open reading frame 162	2905	0.14
chr7_106507057_106507208	0.28	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	1208	0.59
chr1_36500237_36500507	0.28	RP4-665N4.8		21141	0.16
chrX_133523066_133523217	0.28	ENSG00000251962	.	14271	0.17
chr8_27223967_27224118	0.27	PTK2B	protein tyrosine kinase 2 beta	14126	0.22
chr19_2267105_2267256	0.27	OAZ1	ornithine decarboxylase antizyme 1	2305	0.12
chr13_68202936_68203087	0.27	PCDH9	protocadherin 9	398543	0.01
chr4_1581349_1582263	0.27	FAM53A	family with sequence similarity 53, member A	75329	0.08
chr12_64852912_64853865	0.27	TBK1	TANK-binding kinase 1	7133	0.2
chr3_134261756_134261907	0.27	CEP63	centrosomal protein 63kDa	3167	0.29
chr20_48328141_48328292	0.27	B4GALT5	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5	2199	0.3
chr11_46581548_46581763	0.27	AMBRA1	autophagy/beclin-1 regulator 1	31259	0.15
chr8_112438072_112438223	0.26	ENSG00000222146	.	722907	0.0
chr13_32616629_32616780	0.26	FRY-AS1	FRY antisense RNA 1	10928	0.22
chr7_87503109_87503295	0.26	DBF4	DBF4 homolog (S. cerevisiae)	2342	0.29
chr3_47123794_47124082	0.26	ENSG00000251938	.	6160	0.22
chr1_207228136_207228287	0.26	PFKFB2	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	166	0.92
chr10_17269607_17270502	0.26	VIM	vimentin	204	0.89
chr17_29636179_29636457	0.26	EVI2B	ecotropic viral integration site 2B	4784	0.15
chr4_84161976_84162127	0.26	COQ2	coenzyme Q2 4-hydroxybenzoate polyprenyltransferase	43867	0.16
chr3_187492063_187492306	0.25	BCL6	B-cell CLL/lymphoma 6	28669	0.2
chr9_129253296_129253447	0.25	ENSG00000221768	.	39899	0.15
chr16_48411039_48411308	0.25	SIAH1	siah E3 ubiquitin protein ligase 1	8188	0.18
chr17_78755045_78755196	0.25	RP11-28G8.1		24312	0.21
chr12_64798382_64799443	0.25	XPOT	exportin, tRNA	86	0.97
chr8_22961002_22961301	0.25	TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	717	0.58
chr2_103048870_103049021	0.25	ENSG00000264764	.	196	0.9
chr21_36772703_36772854	0.25	ENSG00000211590	.	320235	0.01
chr7_105953972_105954204	0.25	NAMPT	nicotinamide phosphoribosyltransferase	27316	0.2
chr2_207998546_207999225	0.25	KLF7	Kruppel-like factor 7 (ubiquitous)	24	0.98
chr22_31615175_31615326	0.24	ENSG00000199695	.	3589	0.13
chr6_11350314_11350465	0.24	NEDD9	neural precursor cell expressed, developmentally down-regulated 9	32143	0.22
chr13_86159310_86159559	0.24	ENSG00000207012	.	446	0.91
chr22_17598033_17598230	0.24	CECR6	cat eye syndrome chromosome region, candidate 6	4012	0.17
chr3_138524893_138525044	0.24	PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	28626	0.22
chr12_32742094_32742245	0.24	FGD4	FYVE, RhoGEF and PH domain containing 4	9291	0.26
chr5_76112526_76112677	0.24	F2RL1	coagulation factor II (thrombin) receptor-like 1	2157	0.27
chr1_192776419_192777001	0.24	RGS2	regulator of G-protein signaling 2, 24kDa	1461	0.52
chr2_182168845_182168996	0.24	ENSG00000266705	.	1459	0.58
chrX_19703578_19703729	0.24	SH3KBP1	SH3-domain kinase binding protein 1	14537	0.29
chr11_33912422_33912614	0.24	LMO2	LIM domain only 2 (rhombotin-like 1)	1318	0.47
chr10_70850849_70851349	0.24	SRGN	serglycin	3225	0.25
chr20_52370901_52371111	0.24	ENSG00000238468	.	85709	0.09
chr7_17039488_17039788	0.24	AGR3	anterior gradient 3	118027	0.06
chr7_20825937_20826584	0.24	SP8	Sp8 transcription factor	245	0.96
chr18_3453699_3454909	0.24	TGIF1	TGFB-induced factor homeobox 1	532	0.8
chr8_26184784_26184935	0.24	PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	33860	0.18
chr8_56792958_56793527	0.24	LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	848	0.55
chr11_72700714_72700865	0.23	FCHSD2	FCH and double SH3 domains 2	732	0.75
chr12_25208788_25208939	0.23	LRMP	lymphoid-restricted membrane protein	3189	0.26
chr15_38376930_38377081	0.23	TMCO5A	transmembrane and coiled-coil domains 5A	149547	0.04
chr1_226251298_226251924	0.23	H3F3A	H3 histone, family 3A	67	0.97
chr10_17395409_17395560	0.23	ST8SIA6	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	26376	0.16
chr1_221173678_221173829	0.23	HLX	H2.0-like homeobox	119169	0.06
chr7_133456734_133456885	0.23	EXOC4	exocyst complex component 4	158413	0.04
chr6_159071306_159071615	0.23	SYTL3	synaptotagmin-like 3	414	0.83
chr9_132807889_132808048	0.23	FNBP1	formin binding protein 1	2495	0.28
chr21_30543274_30543425	0.23	ENSG00000212479	.	9611	0.13
chr8_131206424_131206650	0.23	ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	13429	0.23
chr20_1550627_1550778	0.23	SIRPB1	signal-regulatory protein beta 1	1856	0.26
chr1_42230520_42230906	0.23	ENSG00000264896	.	5901	0.3
chr14_70111468_70111619	0.22	KIAA0247	KIAA0247	33230	0.18
chr2_178249081_178249232	0.22	AGPS	alkylglycerone phosphate synthase	8216	0.14
chr2_201238626_201239302	0.22	ENSG00000201649	.	1066	0.5
chr6_18391062_18391213	0.22	RNF144B	ring finger protein 144B	3556	0.26
chr16_50059050_50060305	0.22	CNEP1R1	CTD nuclear envelope phosphatase 1 regulatory subunit 1	246	0.93
chr21_36367168_36367319	0.22	RUNX1	runt-related transcription factor 1	54219	0.18
chr7_5594421_5594572	0.22	CTB-161C1.1		1866	0.25
chr6_107297762_107297913	0.22	C6orf203	chromosome 6 open reading frame 203	51570	0.14
chr19_6425167_6425318	0.22	KHSRP	KH-type splicing regulatory protein	437	0.66
chr9_139434770_139435052	0.22	RP11-413M3.4		2422	0.15
chr7_37011253_37011404	0.22	ELMO1	engulfment and cell motility 1	13337	0.2
chr6_41528112_41529137	0.22	FOXP4	forkhead box P4	4863	0.19
chr8_12589361_12589512	0.22	LONRF1	LON peptidase N-terminal domain and ring finger 1	2540	0.26
chr10_119644806_119644957	0.22	RP11-354M20.3		132117	0.05
chr2_215664874_215665025	0.22	BARD1	BRCA1 associated RING domain 1	9448	0.21
chr6_134551187_134551338	0.22	ENSG00000238631	.	23610	0.16
chr5_148189087_148189390	0.22	ADRB2	adrenoceptor beta 2, surface	16918	0.25
chr10_70087727_70088191	0.21	HNRNPH3	heterogeneous nuclear ribonucleoprotein H3 (2H9)	3873	0.2
chr20_46412966_46413363	0.21	SULF2	sulfatase 2	1069	0.59
chr7_50348449_50348781	0.21	IKZF1	IKAROS family zinc finger 1 (Ikaros)	297	0.94
chr10_126664611_126664762	0.21	RP11-298J20.3		29685	0.14
chr13_71409756_71409907	0.21	ENSG00000202433	.	376235	0.01
chr3_50658137_50658523	0.21	MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	3509	0.19
chr3_108988766_108988917	0.21	ENSG00000252889	.	44865	0.15
chr1_200987607_200987758	0.21	KIF21B	kinesin family member 21B	4854	0.21
chr15_45940670_45940821	0.21	SQRDL	sulfide quinone reductase-like (yeast)	2666	0.28
chr13_78434617_78434768	0.21	EDNRB	endothelin receptor type B	58253	0.12
chr12_54891959_54892179	0.21	NCKAP1L	NCK-associated protein 1-like	499	0.73
chr1_173807426_173807577	0.21	DARS2	aspartyl-tRNA synthetase 2, mitochondrial	13704	0.1
chr8_9005081_9005340	0.21	PPP1R3B	protein phosphatase 1, regulatory subunit 3B	2996	0.21
chr15_94796301_94796468	0.21	MCTP2	multiple C2 domains, transmembrane 2	21617	0.29
chr7_139555611_139555822	0.21	TBXAS1	thromboxane A synthase 1 (platelet)	26606	0.23
chr3_122029046_122029197	0.21	CSTA	cystatin A (stefin A)	14970	0.16
chr11_59949160_59949311	0.21	MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	96	0.97
chr1_169679248_169679951	0.21	SELL	selectin L	1240	0.48
chr12_12510418_12511218	0.21	LOH12CR1	loss of heterozygosity, 12, chromosomal region 1	466	0.63
chr5_39412000_39412151	0.21	DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	12895	0.26
chr22_36843986_36844137	0.21	ENSG00000252225	.	7046	0.15
chr3_194821900_194822051	0.21	XXYLT1-AS1	XXYLT1 antisense RNA 1	6658	0.17
chr4_139635357_139635508	0.21	ENSG00000238971	.	97488	0.08
chr1_225610206_225610357	0.21	LBR	lamin B receptor	5318	0.2
chr11_14375529_14375805	0.21	RRAS2	related RAS viral (r-ras) oncogene homolog 2	379	0.91
chr3_58341767_58341918	0.21	PXK	PX domain containing serine/threonine kinase	22809	0.17
chr9_85107233_85107384	0.21	SPATA31D1	SPATA31 subfamily D, member 1	503621	0.0
chr19_13208223_13208471	0.20	LYL1	lymphoblastic leukemia derived sequence 1	5334	0.11
chr4_68636095_68636246	0.20	GNRHR	gonadotropin-releasing hormone receptor	16092	0.17
chr5_96297085_96297358	0.20	ENSG00000200884	.	1240	0.43
chr13_99910339_99910626	0.20	GPR18	G protein-coupled receptor 18	146	0.96
chr19_19083033_19083500	0.20	ENSG00000241172	.	14199	0.1
chr14_88471433_88472132	0.20	GPR65	G protein-coupled receptor 65	314	0.88
chr9_141104243_141104394	0.20	TUBBP5	tubulin, beta pseudogene 5	34821	0.19
chr8_131290835_131290986	0.20	ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	31622	0.23
chr7_83932213_83932364	0.20	SEMA3A	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	107527	0.08
chr1_29253817_29254129	0.20	EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	12882	0.18
chr2_148386736_148386887	0.20	ENSG00000253083	.	84312	0.09
chr4_87930908_87931059	0.20	AFF1	AF4/FMR2 family, member 1	2562	0.39
chr9_20490881_20491032	0.20	ENSG00000264941	.	11384	0.23
chr4_79473579_79473973	0.20	ANXA3	annexin A3	655	0.79
chr17_56736328_56736479	0.20	ENSG00000202077	.	263	0.86
chr15_99444137_99444307	0.20	RP11-654A16.1		7458	0.22
chr8_102506754_102506905	0.20	GRHL2	grainyhead-like 2 (Drosophila)	1843	0.34
chr9_101881133_101881552	0.20	TGFBR1	transforming growth factor, beta receptor 1	8715	0.21
chr2_149863937_149864088	0.20	LYPD6B	LY6/PLAUR domain containing 6B	30969	0.22
chr6_6396318_6396469	0.20	F13A1	coagulation factor XIII, A1 polypeptide	75147	0.11
chr12_100522777_100522928	0.20	UHRF1BP1L	UHRF1 binding protein 1-like	13773	0.13
chr3_15336001_15336152	0.20	SH3BP5	SH3-domain binding protein 5 (BTK-associated)	18524	0.13
chr3_136557614_136557868	0.20	RP11-731C17.2		122	0.96
chr5_88484775_88484926	0.20	MEF2C-AS1	MEF2C antisense RNA 1	223158	0.02
chr14_68320261_68320412	0.20	RAD51B	RAD51 paralog B	30075	0.16
chr2_70368629_70369219	0.20	C2orf42	chromosome 2 open reading frame 42	40203	0.11
chr14_32555117_32555268	0.20	ARHGAP5	Rho GTPase activating protein 5	7755	0.21

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ALX3

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0002538	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.1	0.2	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.1	0.3	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
0.1	0.3	GO:0006089	lactate metabolic process(GO:0006089)
0.1	0.2	GO:0071569	protein ufmylation(GO:0071569)
0.1	0.2	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.1	0.2	GO:0001821	histamine secretion(GO:0001821)
0.1	0.2	GO:0002283	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.1	0.2	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.1	0.2	GO:0010447	response to acidic pH(GO:0010447)
0.1	0.2	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.1	0.2	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.4	GO:0050860	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.4	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0	0.1	GO:0032811	negative regulation of epinephrine secretion(GO:0032811)
0.0	0.2	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.1	GO:0014041	regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0	0.2	GO:0055064	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.1	GO:0001714	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.1	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.1	GO:0003161	cardiac conduction system development(GO:0003161)
0.0	0.2	GO:0042119	neutrophil activation(GO:0042119)
0.0	0.2	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.0	0.2	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.2	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.2	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.1	GO:0060972	left/right pattern formation(GO:0060972)
0.0	0.1	GO:0046398	UDP-glucuronate metabolic process(GO:0046398)
0.0	0.4	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.1	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.1	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0	0.2	GO:0009820	alkaloid metabolic process(GO:0009820)
0.0	0.1	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.2	GO:0032528	microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0	0.1	GO:0019049	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.1	GO:0009215	purine deoxyribonucleoside triphosphate metabolic process(GO:0009215)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.1	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.1	GO:0009249	protein lipoylation(GO:0009249)
0.0	0.4	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.1	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.1	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.0	0.1	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.1	GO:0042494	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.1	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.1	GO:0060017	parathyroid gland development(GO:0060017)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.2	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0	0.1	GO:0051642	centrosome localization(GO:0051642)
0.0	0.1	GO:0045986	negative regulation of smooth muscle contraction(GO:0045986)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.0	GO:0002902	regulation of B cell apoptotic process(GO:0002902)
0.0	0.1	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0	0.0	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.1	GO:0034088	maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.0	0.1	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.1	GO:0050689	negative regulation of defense response to virus by host(GO:0050689)
0.0	0.1	GO:0015671	oxygen transport(GO:0015671)
0.0	0.1	GO:0045617	negative regulation of keratinocyte differentiation(GO:0045617)
0.0	0.0	GO:0045410	positive regulation of interleukin-6 biosynthetic process(GO:0045410)
0.0	0.1	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.0	GO:0060396	growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0046504	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.0	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.0	GO:0033091	positive regulation of immature T cell proliferation(GO:0033091)
0.0	0.0	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.1	GO:0042976	activation of Janus kinase activity(GO:0042976)
0.0	0.1	GO:0032957	inositol trisphosphate metabolic process(GO:0032957)
0.0	0.2	GO:0050853	B cell receptor signaling pathway(GO:0050853)
0.0	0.1	GO:0032100	positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.0	0.1	GO:0031394	regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0	0.2	GO:0050798	activated T cell proliferation(GO:0050798)
0.0	0.0	GO:0060124	positive regulation of growth hormone secretion(GO:0060124)
0.0	0.0	GO:0046607	positive regulation of centrosome cycle(GO:0046607)
0.0	0.1	GO:0071675	mononuclear cell migration(GO:0071674) regulation of mononuclear cell migration(GO:0071675)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.0	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.0	GO:0002890	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.0	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.1	GO:0007064	mitotic sister chromatid cohesion(GO:0007064)
0.0	0.1	GO:0043249	erythrocyte maturation(GO:0043249)
0.0	0.0	GO:0002360	T cell lineage commitment(GO:0002360)
0.0	0.2	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.0	0.0	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.0	GO:0002669	lymphocyte anergy(GO:0002249) T cell tolerance induction(GO:0002517) regulation of T cell tolerance induction(GO:0002664) positive regulation of T cell tolerance induction(GO:0002666) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.0	GO:0034776	response to histamine(GO:0034776)
0.0	0.0	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.0	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.0	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.0	GO:0032627	interleukin-23 production(GO:0032627) regulation of interleukin-23 production(GO:0032667)
0.0	0.0	GO:0019532	oxalate transport(GO:0019532)
0.0	0.0	GO:0061384	heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0	0.0	GO:0002220	innate immune response activating cell surface receptor signaling pathway(GO:0002220)
0.0	0.0	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.1	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.1	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.0	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.1	GO:0010324	phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0	0.0	GO:0044380	protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0	0.1	GO:0006744	ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744)
0.0	0.0	GO:0031573	intra-S DNA damage checkpoint(GO:0031573)
0.0	0.1	GO:0044116	growth involved in symbiotic interaction(GO:0044110) growth of symbiont involved in interaction with host(GO:0044116) growth of symbiont in host(GO:0044117) regulation of growth of symbiont in host(GO:0044126) negative regulation of growth of symbiont in host(GO:0044130) modulation of growth of symbiont involved in interaction with host(GO:0044144) negative regulation of growth of symbiont involved in interaction with host(GO:0044146)
0.0	0.0	GO:0055022	negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0	0.0	GO:0071698	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0	0.3	GO:0015682	ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.0	0.1	GO:0048668	collateral sprouting(GO:0048668)
0.0	0.0	GO:0007100	mitotic centrosome separation(GO:0007100)
0.0	0.0	GO:0001973	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.3	GO:0046847	filopodium assembly(GO:0046847)
0.0	0.0	GO:0016559	peroxisome fission(GO:0016559)
0.0	0.1	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.0	0.1	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0	0.1	GO:0015781	pyrimidine nucleotide-sugar transport(GO:0015781)
0.0	0.0	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0	0.0	GO:0015705	iodide transport(GO:0015705)
0.0	0.1	GO:0015884	folic acid transport(GO:0015884)
0.0	0.1	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	0.3	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.2	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.1	GO:0031313	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0	0.1	GO:0017059	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.1	GO:0042629	mast cell granule(GO:0042629)
0.0	0.1	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.4	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0070062	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.1	GO:0001740	Barr body(GO:0001740)
0.0	0.1	GO:0005638	lamin filament(GO:0005638)
0.0	0.1	GO:0031229	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.0	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.1	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.2	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.1	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.1	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.2	GO:0017119	Golgi transport complex(GO:0017119)
0.0	0.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.1	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.1	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.0	0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.2	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.0	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.1	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.0	0.1	GO:0005675	holo TFIIH complex(GO:0005675)
0.0	0.0	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.1	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0	0.1	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.1	GO:0031010	ISWI-type complex(GO:0031010)
0.0	0.0	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0050544	arachidonic acid binding(GO:0050544)
0.1	0.4	GO:0001846	opsonin binding(GO:0001846)
0.1	0.2	GO:0004516	nicotinate phosphoribosyltransferase activity(GO:0004516)
0.1	0.4	GO:0001784	phosphotyrosine binding(GO:0001784)
0.1	0.2	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.1	0.2	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1	0.2	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.1	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.1	GO:0016454	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.2	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.6	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.3	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.3	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.2	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.2	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.3	GO:0016303	1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0	0.2	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.1	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.0	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0052742	phosphatidylinositol kinase activity(GO:0052742)
0.0	0.1	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.1	GO:0043559	insulin binding(GO:0043559)
0.0	0.1	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.3	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.1	GO:0031849	olfactory receptor binding(GO:0031849)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.2	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.1	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.0	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.0	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.4	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.1	GO:0008517	folic acid transporter activity(GO:0008517)
0.0	0.1	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.1	GO:0070569	uridylyltransferase activity(GO:0070569)
0.0	0.1	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.0	GO:0004525	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0	0.0	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.1	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.1	GO:0010340	carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.0	0.0	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.1	GO:0016423	tRNA (guanine) methyltransferase activity(GO:0016423)
0.0	0.0	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.0	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.0	GO:0002060	purine nucleobase binding(GO:0002060)
0.0	0.1	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0	0.1	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.1	GO:0003960	NADPH:quinone reductase activity(GO:0003960)
0.0	0.2	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0	0.0	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.0	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.1	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.3	GO:0017022	myosin binding(GO:0017022)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.0	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.2	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.0	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.0	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.0	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.2	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.2	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.0	0.3	GO:0000049	tRNA binding(GO:0000049)
0.0	0.0	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.1	GO:0004383	guanylate cyclase activity(GO:0004383)
0.0	0.3	GO:0019003	GDP binding(GO:0019003)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.0	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.0	GO:0004875	complement receptor activity(GO:0004875)
0.0	0.0	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.0	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.0	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.0	GO:0034594	phosphatidylinositol trisphosphate phosphatase activity(GO:0034594)
0.0	0.1	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.0	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.1	GO:0008273	calcium, potassium:sodium antiporter activity(GO:0008273)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.0	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.3	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.4	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.4	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.7	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.6	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.5	PID IL1 PATHWAY	IL1-mediated signaling events
0.2	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.4	PID TRAIL PATHWAY	TRAIL signaling pathway
0.1	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.3	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.3	PID ERBB1 RECEPTOR PROXIMAL PATHWAY	EGF receptor (ErbB1) signaling pathway
0.3	PID RHOA PATHWAY	RhoA signaling pathway
0.5	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.1	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.2	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.3	PID TNF PATHWAY	TNF receptor signaling pathway
0.1	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.5	PID FOXO PATHWAY	FoxO family signaling
0.1	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2	PID ARF 3PATHWAY	Arf1 pathway
0.1	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.4	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.5	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.1	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.2	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.3	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.1	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.1	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.2	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.7	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.0	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.2	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells
0.1	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.3	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.4	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.5	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.1	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.1	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.2	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.3	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.4	REACTOME GAB1 SIGNALOSOME	Genes involved in GAB1 signalosome
0.2	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.2	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.0	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.1	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.2	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.3	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2	REACTOME RNA POL I TRANSCRIPTION INITIATION	Genes involved in RNA Polymerase I Transcription Initiation
0.0	REACTOME ACYL CHAIN REMODELLING OF PE	Genes involved in Acyl chain remodelling of PE
0.2	REACTOME IL 2 SIGNALING	Genes involved in Interleukin-2 signaling
0.2	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation