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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ARID5B

Z-value: 1.60

Motif logo

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Transcription factors associated with ARID5B

Gene Symbol Gene ID Gene Info
ARID5B
ENSG00000150347.10 ARID5B

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
ARID5Bchr10_63598059_63598210629250.1329950.771.4e-02Click!
ARID5Bchr10_63816154_6381630572590.2801190.751.9e-02Click!
ARID5Bchr10_63785952_63786103229430.2422760.752.1e-02Click!
ARID5Bchr10_63656807_6365695841770.295667-0.684.3e-02Click!
ARID5Bchr10_63597664_63597815633200.1321520.674.7e-02Click!

Activity of the ARID5B motif across conditions

Conditions sorted by the z-value of the ARID5B motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr21_36256728_36257172 0.54 RUNX1
 runt-related transcription factor 1
 2530
 0.42
chr21_35133624_35133954 0.50 ITSN1
 intersectin 1 (SH3 domain protein)
 26443
 0.2
chr8_126013201_126013598 0.45 SQLE
 squalene epoxidase
 2613
 0.23
chr4_177874509_177874660 0.40 VEGFC
 vascular endothelial growth factor C
 160703
 0.04
chr8_116594269_116594420 0.39 TRPS1
 trichorhinophalangeal syndrome I
 37953
 0.21
chr8_102802440_102802591 0.39 NCALD
 neurocalcin delta
 660
 0.79
chr4_57975072_57975270 0.37 IGFBP7-AS1
 IGFBP7 antisense RNA 1
 757
 0.52
chr13_96704851_96705002 0.36 UGGT2
 UDP-glucose glycoprotein glucosyltransferase 2
 711
 0.77
chr8_81400855_81401257 0.36 ZBTB10
 zinc finger and BTB domain containing 10
 2608
 0.27
chr13_33162802_33163103 0.36 PDS5B
 PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
 2388
 0.38
chr4_16899723_16900066 0.36 LDB2
 LIM domain binding 2
 291
 0.95
chr18_18944170_18944321 0.35 GREB1L
 growth regulation by estrogen in breast cancer-like
 691
 0.74
chr17_66951279_66951576 0.34 ABCA8
 ATP-binding cassette, sub-family A (ABC1), member 8
 45
 0.98
chr14_55239224_55239463 0.34 SAMD4A
 sterile alpha motif domain containing 4A
 17792
 0.24
chr2_190042021_190042178 0.33 COL5A2
 collagen, type V, alpha 2
 2506
 0.34
chr3_16219029_16219297 0.33 GALNT15
 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
 2947
 0.33
chr21_17652326_17652785 0.32 ENSG00000201025
 .
 4534
 0.36
chr14_101292536_101293492 0.32 AL117190.2
2523
 0.08
chr12_115105992_115106327 0.32 ENSG00000199220
 .
 10292
 0.22
chr8_12986829_12986980 0.31 DLC1
 deleted in liver cancer 1
 4079
 0.28
chrX_101054612_101054832 0.30 NXF5
 nuclear RNA export factor 5
 43449
 0.14
chr4_89978098_89978439 0.30 FAM13A
 family with sequence similarity 13, member A
 43
 0.98
chr4_77610213_77610516 0.30 AC107072.2
51588
 0.12
chr5_99930860_99931067 0.30 FAM174A
 family with sequence similarity 174, member A
 59954
 0.16
chr10_264410_264561 0.30 ZMYND11
 zinc finger, MYND-type containing 11
 8594
 0.22
chr6_46292394_46292545 0.29 RCAN2
 regulator of calcineurin 2
 936
 0.7
chr1_156540904_156541055 0.29 IQGAP3
 IQ motif containing GTPase activating protein 3
 1353
 0.26
chr5_98111208_98111383 0.29 RGMB
 repulsive guidance molecule family member b
 1956
 0.33
chr1_103571993_103572213 0.29 COL11A1
 collagen, type XI, alpha 1
 1631
 0.56
chr13_36048764_36048946 0.29 MAB21L1
 mab-21-like 1 (C. elegans)
 1977
 0.3
chrX_117481980_117482135 0.29 WDR44
 WD repeat domain 44
 1951
 0.37
chr16_15951360_15951580 0.29 MYH11
 myosin, heavy chain 11, smooth muscle
 580
 0.71
chr2_162166890_162167041 0.29 PSMD14
 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
 1854
 0.36
chr13_45147177_45147503 0.29 TSC22D1
 TSC22 domain family, member 1
 3052
 0.35
chr18_56244732_56244930 0.29 RP11-126O1.2
20529
 0.14
chr5_146859281_146859432 0.28 DPYSL3
 dihydropyrimidinase-like 3
 25527
 0.24
chr10_17273946_17274204 0.28 VIM
 vimentin
 1467
 0.3
chr4_177711391_177711542 0.28 VEGFC
 vascular endothelial growth factor C
 2415
 0.44
chr8_77320139_77320373 0.28 ENSG00000222231
 .
 142289
 0.05
chr14_91478586_91478737 0.27 RPS6KA5
 ribosomal protein S6 kinase, 90kDa, polypeptide 5
 47817
 0.13
chr7_130590792_130591004 0.27 ENSG00000226380
 .
 28600
 0.21
chr2_106260790_106261225 0.27 NCK2
 NCK adaptor protein 2
 100347
 0.08
chr3_21955222_21955373 0.27 ENSG00000221384
 .
 84067
 0.11
chr9_91791725_91791876 0.27 SHC3
 SHC (Src homology 2 domain containing) transforming protein 3
 1882
 0.43
chr11_125920446_125920597 0.27 CDON
 cell adhesion associated, oncogene regulated
 12185
 0.2
chr5_124078453_124078604 0.27 ZNF608
 zinc finger protein 608
 1686
 0.26
chr4_21769993_21770244 0.27 KCNIP4
 Kv channel interacting protein 4
 70721
 0.12
chr9_25677269_25678110 0.27 TUSC1
 tumor suppressor candidate 1
 1167
 0.68
chr5_92919252_92919403 0.27 NR2F1
 nuclear receptor subfamily 2, group F, member 1
 284
 0.9
chr19_52956436_52957233 0.27 ZNF578
 zinc finger protein 578
 5
 0.97
chr15_99789888_99790153 0.27 TTC23
 tetratricopeptide repeat domain 23
 205
 0.9
chr9_140524469_140524620 0.27 EHMT1
 euchromatic histone-lysine N-methyltransferase 1
 11090
 0.13
chr3_148897296_148897508 0.27 CP
 ceruloplasmin (ferroxidase)
 6
 0.98
chr16_73096665_73097349 0.26 ZFHX3
 zinc finger homeobox 3
 3410
 0.3
chr18_51886495_51886646 0.26 C18orf54
 chromosome 18 open reading frame 54
 1615
 0.37
chr2_112195055_112195206 0.26 ENSG00000266139
 .
 116462
 0.07
chr3_122201810_122202029 0.26 KPNA1
 karyopherin alpha 1 (importin alpha 5)
 31470
 0.14
chr16_51188825_51189552 0.26 SALL1
 spalt-like transcription factor 1
 4002
 0.28
chr6_151562009_151562901 0.25 AKAP12
 A kinase (PRKA) anchor protein 12
 946
 0.51
chr6_27722212_27722363 0.25 HIST1H2BL
 histone cluster 1, H2bl
 53422
 0.06
chr10_86184623_86185188 0.25 CCSER2
 coiled-coil serine-rich protein 2
 210
 0.97
chr11_10428526_10428677 0.25 ENSG00000221574
 .
 7737
 0.21
chr17_57449730_57449881 0.25 ENSG00000263857
 .
 6361
 0.19
chr7_134539898_134540267 0.25 CALD1
 caldesmon 1
 11447
 0.28
chr6_56996023_56996174 0.25 RP11-203B9.4
39749
 0.13
chr1_164529707_164529858 0.25 PBX1
 pre-B-cell leukemia homeobox 1
 722
 0.78
chr18_53090404_53090609 0.25 TCF4
 transcription factor 4
 763
 0.7
chr8_29027351_29027502 0.25 ENSG00000264328
 .
 27216
 0.15
chr5_179047232_179047712 0.25 HNRNPH1
 heterogeneous nuclear ribonucleoprotein H1 (H)
 488
 0.71
chr3_154517752_154517903 0.25 MME
 membrane metallo-endopeptidase
 224086
 0.02
chr2_216283516_216283667 0.25 FN1
 fibronectin 1
 17199
 0.2
chr3_170302671_170302921 0.25 SLC7A14
 solute carrier family 7, member 14
 1067
 0.64
chrX_151039282_151039625 0.25 RP11-366F6.2
40218
 0.13
chr2_87812694_87812845 0.25 RP11-1399P15.1
35216
 0.22
chr18_64307786_64307937 0.25 ENSG00000221536
 .
 12877
 0.26
chr12_32261156_32261307 0.25 RP11-843B15.2
769
 0.51
chr3_9945019_9945243 0.25 IL17RE
 interleukin 17 receptor E
 565
 0.54
chr12_20525245_20525493 0.24 RP11-284H19.1
2173
 0.35
chr17_59478534_59478762 0.24 RP11-332H18.5
1044
 0.31
chr5_169407172_169407407 0.24 FAM196B
 family with sequence similarity 196, member B
 455
 0.87
chr2_145201691_145201842 0.24 ZEB2
 zinc finger E-box binding homeobox 2
 13629
 0.27
chr4_169951673_169951824 0.24 RP11-483A20.3
20167
 0.17
chr3_23245710_23245894 0.24 UBE2E2
 ubiquitin-conjugating enzyme E2E 2
 1018
 0.51
chr10_112853696_112853847 0.24 ADRA2A
 adrenoceptor alpha 2A
 16981
 0.25
chr4_169616116_169616373 0.24 ENSG00000206613
 .
 8377
 0.21
chr2_197852125_197852688 0.24 ANKRD44
 ankyrin repeat domain 44
 12820
 0.25
chrX_130962862_130963372 0.24 ENSG00000200587
 .
 109867
 0.07
chr14_69657871_69659182 0.24 EXD2
 exonuclease 3'-5' domain containing 2
 3
 0.98
chrY_7395560_7395750 0.24 ENSG00000252472
 .
 104456
 0.07
chr7_93552513_93552820 0.24 GNG11
 guanine nucleotide binding protein (G protein), gamma 11
 1655
 0.33
chr7_72933105_72933537 0.24 BAZ1B
 bromodomain adjacent to zinc finger domain, 1B
 3281
 0.19
chr12_117096463_117096618 0.24 C12orf49
 chromosome 12 open reading frame 49
 61392
 0.12
chr19_17559208_17559695 0.23 TMEM221
 transmembrane protein 221
 75
 0.93
chr12_5019229_5019602 0.23 KCNA1
 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
 344
 0.92
chr1_101359369_101359680 0.23 EXTL2
 exostosin-like glycosyltransferase 2
 696
 0.48
chr16_83847696_83847847 0.23 HSBP1
 heat shock factor binding protein 1
 6177
 0.18
chrX_133509784_133510099 0.23 PHF6
 PHD finger protein 6
 2538
 0.28
chr8_99258580_99258731 0.23 NIPAL2
 NIPA-like domain containing 2
 47909
 0.13
chr17_9264144_9264295 0.23 RP11-85B7.4
77728
 0.09
chr3_58067974_58068125 0.23 FLNB
 filamin B, beta
 3836
 0.31
chr8_116678925_116679076 0.23 TRPS1
 trichorhinophalangeal syndrome I
 1208
 0.65
chr10_63422698_63423173 0.23 C10orf107
 chromosome 10 open reading frame 107
 180
 0.96
chr10_69022435_69022586 0.23 CTNNA3
 catenin (cadherin-associated protein), alpha 3
 82309
 0.11
chr16_85038693_85039085 0.23 ZDHHC7
 zinc finger, DHHC-type containing 7
 273
 0.93
chr7_23514811_23514962 0.23 IGF2BP3
 insulin-like growth factor 2 mRNA binding protein 3
 4800
 0.19
chr2_36473952_36474103 0.23 CRIM1
 cysteine rich transmembrane BMP regulator 1 (chordin-like)
 109042
 0.07
chr17_57505253_57505417 0.22 RP11-567L7.5
24671
 0.18
chr7_44922298_44922675 0.22 ENSG00000264326
 .
 1087
 0.34
chr10_21804577_21804741 0.22 SKIDA1
 SKI/DACH domain containing 1
 2189
 0.22
chr4_122926968_122927132 0.22 TRPC3
 transient receptor potential cation channel, subfamily C, member 3
 54141
 0.14
chr3_64253305_64253544 0.22 PRICKLE2
 prickle homolog 2 (Drosophila)
 231
 0.95
chr7_19145557_19145708 0.22 AC003986.6
6465
 0.17
chr22_46476561_46476775 0.22 FLJ27365
 hsa-mir-4763
 476
 0.66
chr1_101312973_101313135 0.22 EXTL2
 exostosin-like glycosyltransferase 2
 47166
 0.12
chr5_111083741_111083964 0.22 NREP
 neuronal regeneration related protein
 8096
 0.21
chr1_225117686_225118141 0.22 DNAH14
 dynein, axonemal, heavy chain 14
 529
 0.87
chr21_41421632_41421805 0.22 ENSG00000263973
 .
 162640
 0.04
chr6_133240538_133240737 0.22 ENSG00000200534
 .
 102279
 0.06
chr6_85468375_85468673 0.22 TBX18
 T-box 18
 4549
 0.33
chr6_46816549_46816814 0.22 GPR116
 G protein-coupled receptor 116
 22921
 0.18
chr12_27164586_27164737 0.22 TM7SF3
 transmembrane 7 superfamily member 3
 1286
 0.39
chr16_89392054_89392556 0.22 AC137932.6
2673
 0.19
chr6_165341863_165342014 0.22 C6orf118
 chromosome 6 open reading frame 118
 380404
 0.01
chr6_19838575_19839711 0.22 RP1-167F1.2
168
 0.95
chr9_10208018_10208266 0.22 PTPRD
 protein tyrosine phosphatase, receptor type, D
 174352
 0.04
chr14_61910692_61910843 0.21 PRKCH
 protein kinase C, eta
 1491
 0.5
chr2_43695032_43695183 0.21 ENSG00000252804
 .
 59661
 0.14
chr8_68864615_68865211 0.21 PREX2
 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
 560
 0.86
chr14_57273831_57273982 0.21 OTX2
 orthodenticle homeobox 2
 1525
 0.35
chr15_98065206_98065387 0.21 ENSG00000251729
 .
 49814
 0.19
chr19_37903473_37903682 0.21 ZNF569
 zinc finger protein 569
 32284
 0.12
chr13_99630412_99630628 0.21 DOCK9
 dedicator of cytokinesis 9
 182
 0.96
chr9_35341457_35341792 0.21 AL160274.1
 HCG17281; PRO0038; Uncharacterized protein
 19638
 0.2
chr1_182992978_182993852 0.21 LAMC1
 laminin, gamma 1 (formerly LAMB2)
 820
 0.64
chr10_101419068_101420090 0.21 ENTPD7
 ectonucleoside triphosphate diphosphohydrolase 7
 316
 0.86
chr8_77317816_77317967 0.21 ENSG00000222231
 .
 139924
 0.05
chr2_225751095_225751267 0.21 DOCK10
 dedicator of cytokinesis 10
 60601
 0.16
chr11_108767349_108767500 0.21 ENSG00000201243
 .
 108820
 0.07
chr18_51886872_51887023 0.21 C18orf54
 chromosome 18 open reading frame 54
 1992
 0.33
chr16_11458815_11458966 0.21 RP11-485G7.6
15712
 0.09
chr15_30112674_30113382 0.21 TJP1
 tight junction protein 1
 723
 0.64
chr15_57353772_57353923 0.21 ENSG00000222586
 .
 95252
 0.08
chr6_80340519_80340952 0.21 SH3BGRL2
 SH3 domain binding glutamic acid-rich protein like 2
 265
 0.95
chr4_53863026_53863177 0.21 RP11-752D24.2
51245
 0.16
chr1_199824347_199824498 0.21 ENSG00000200139
 .
 32865
 0.22
chr10_89629938_89630093 0.21 KLLN
 killin, p53-regulated DNA replication inhibitor
 6821
 0.14
chr4_107939121_107939272 0.21 DKK2
 dickkopf WNT signaling pathway inhibitor 2
 18258
 0.28
chr16_14282323_14282474 0.20 MKL2
 MKL/myocardin-like 2
 1626
 0.41
chr1_117117499_117117673 0.20 CD58
 CD58 molecule
 3925
 0.2
chr5_43306439_43306623 0.20 HMGCS1
 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
 6795
 0.21
chr7_120631344_120631706 0.20 CPED1
 cadherin-like and PC-esterase domain containing 1
 1849
 0.35
chr3_66139685_66140118 0.20 SLC25A26
 solute carrier family 25 (S-adenosylmethionine carrier), member 26
 20616
 0.25
chr2_161726328_161726479 0.20 ENSG00000244372
 .
 7655
 0.32
chr8_118990990_118991291 0.20 EXT1
 exostosin glycosyltransferase 1
 131513
 0.06
chr9_18976648_18977105 0.20 FAM154A
 family with sequence similarity 154, member A
 56310
 0.1
chr4_146855885_146856036 0.20 ZNF827
 zinc finger protein 827
 3663
 0.28
chr4_166252557_166253372 0.20 MSMO1
 methylsterol monooxygenase 1
 3885
 0.25
chr1_182931948_182932121 0.20 ENSG00000264768
 .
 3324
 0.2
chr6_15399360_15399511 0.20 JARID2
 jumonji, AT rich interactive domain 2
 1654
 0.48
chr4_4764717_4764868 0.20 MSX1
 msh homeobox 1
 96601
 0.08
chr12_115340794_115340945 0.20 ENSG00000252459
 .
 165360
 0.04
chr2_38295840_38295991 0.20 RMDN2-AS1
 RMDN2 antisense RNA 1
 1731
 0.34
chr8_136478308_136478499 0.20 KHDRBS3
 KH domain containing, RNA binding, signal transduction associated 3
 7453
 0.25
chr1_192508213_192508364 0.20 RP5-1011O1.2
28059
 0.18
chr6_52514241_52514392 0.20 RP1-152L7.5
15756
 0.19
chr5_145827885_145828143 0.20 TCERG1
 transcription elongation regulator 1
 1119
 0.56
chr2_201308521_201308672 0.20 SPATS2L
 spermatogenesis associated, serine-rich 2-like
 3224
 0.27
chr5_102203960_102204196 0.20 PAM
 peptidylglycine alpha-amidating monooxygenase
 2258
 0.46
chr2_228028292_228028853 0.20 COL4A4
 collagen, type IV, alpha 4
 257
 0.8
chr18_22907743_22907894 0.20 ZNF521
 zinc finger protein 521
 23339
 0.23
chr7_80270291_80270524 0.20 CD36
 CD36 molecule (thrombospondin receptor)
 2415
 0.44
chr1_167298272_167298450 0.20 POU2F1
 POU class 2 homeobox 1
 80
 0.98
chr6_74423009_74423160 0.20 RP11-553A21.3
17230
 0.19
chr3_190580567_190581193 0.20 GMNC
 geminin coiled-coil domain containing
 476
 0.9
chr4_152021608_152021943 0.20 RPS3A
 ribosomal protein S3A
 750
 0.52
chr10_36739274_36739523 0.20 ENSG00000237002
 .
 11809
 0.29
chr18_53253489_53253863 0.20 TCF4
 transcription factor 4
 326
 0.93
chr9_21991792_21991943 0.20 CDKN2A
 cyclin-dependent kinase inhibitor 2A
 2543
 0.19
chr13_43843656_43843899 0.20 ENOX1
 ecto-NOX disulfide-thiol exchanger 1
 91436
 0.1
chr12_50608832_50609096 0.20 RP3-405J10.4
4423
 0.14
chr11_78919156_78919307 0.19 TENM4
 teneurin transmembrane protein 4
 7723
 0.32
chr3_181432212_181432363 0.19 SOX2
 SRY (sex determining region Y)-box 2
 2565
 0.33
chr6_158080284_158080435 0.19 ZDHHC14
 zinc finger, DHHC-type containing 14
 66318
 0.12
chr2_98281303_98281454 0.19 ENSG00000201806
 .
 184
 0.78
chr13_50194281_50194827 0.19 ARL11
 ADP-ribosylation factor-like 11
 7881
 0.21
chr5_179048814_179048995 0.19 HNRNPH1
 heterogeneous nuclear ribonucleoprotein H1 (H)
 392
 0.78
chr21_40985164_40985421 0.19 C21orf88
 chromosome 21 open reading frame 88
 544
 0.78
chr1_52340451_52340602 0.19 NRD1
 nardilysin (N-arginine dibasic convertase)
 3165
 0.18
chr9_130854010_130854186 0.19 SLC25A25
 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
 355
 0.73
chr12_13353569_13354032 0.19 EMP1
 epithelial membrane protein 1
 4080
 0.3
chr2_210390985_210391683 0.19 MAP2
 microtubule-associated protein 2
 52705
 0.18
chr2_191199116_191199267 0.19 INPP1
 inositol polyphosphate-1-phosphatase
 9005
 0.21
chr13_60737053_60737204 0.19 DIAPH3
 diaphanous-related formin 3
 772
 0.67
chr6_124127968_124128119 0.19 NKAIN2
 Na+/K+ transporting ATPase interacting 2
 2697
 0.32
chr2_202903591_202903816 0.19 FZD7
 frizzled family receptor 7
 4393
 0.2
chr2_14633353_14633613 0.19 FAM84A
 family with sequence similarity 84, member A
 139327
 0.05
chr7_39649759_39649910 0.19 AC004837.4
55
 0.97
chr2_20927770_20927921 0.19 GDF7
 growth differentiation factor 7
 61421
 0.12
chr14_45433796_45433989 0.19 FAM179B
 family with sequence similarity 179, member B
 2450
 0.23
chr5_95069419_95069570 0.19 CTD-2154I11.2
1495
 0.34

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of ARID5B

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0050923 regulation of negative chemotaxis(GO:0050923)
0.1 0.3 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.1 0.2 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.1 0.3 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.1 0.2 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.1 0.3 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 0.3 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.1 0.2 GO:0071688 skeletal muscle myosin thick filament assembly(GO:0030241) myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688)
0.1 0.2 GO:0035583 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1 0.3 GO:1903672 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.1 0.1 GO:0060677 ureteric bud elongation(GO:0060677)
0.1 0.2 GO:0060596 mammary placode formation(GO:0060596)
0.1 0.4 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1 0.2 GO:0032236 obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0 0.3 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.2 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.1 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.1 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.3 GO:0022617 extracellular matrix disassembly(GO:0022617)
0.0 0.2 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.1 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0 0.1 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.0 0.2 GO:0030853 negative regulation of granulocyte differentiation(GO:0030853)
0.0 0.2 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.2 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 0.2 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 0.2 GO:0043116 negative regulation of vascular permeability(GO:0043116)
0.0 0.1 GO:0046185 aldehyde catabolic process(GO:0046185)
0.0 0.1 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 0.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.1 GO:0072393 microtubule anchoring at microtubule organizing center(GO:0072393)
0.0 0.1 GO:0060754 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.1 GO:0031223 auditory behavior(GO:0031223)
0.0 0.1 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.2 GO:0045920 negative regulation of exocytosis(GO:0045920)
0.0 0.1 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.0 0.1 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.0 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.1 GO:0097061 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0 0.1 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.0 0.4 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.2 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.5 GO:0032330 regulation of chondrocyte differentiation(GO:0032330)
0.0 0.1 GO:0002069 columnar/cuboidal epithelial cell maturation(GO:0002069)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.0 0.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.1 GO:0033088 negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0 0.2 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.1 GO:0021800 cerebral cortex tangential migration(GO:0021800)
0.0 0.3 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0 0.2 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0 0.1 GO:0061299 retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.2 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0 0.1 GO:0090116 DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0 0.0 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 0.1 GO:2000050 regulation of non-canonical Wnt signaling pathway(GO:2000050)
0.0 0.1 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.0 0.0 GO:0048539 bone marrow development(GO:0048539)
0.0 0.1 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.1 GO:0072048 pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048)
0.0 0.0 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.1 GO:0019934 cGMP-mediated signaling(GO:0019934)
0.0 0.1 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.1 GO:0051570 regulation of histone H3-K9 methylation(GO:0051570)
0.0 0.5 GO:0035136 forelimb morphogenesis(GO:0035136)
0.0 0.0 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0 0.1 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.0 0.1 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.1 GO:0048488 synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0 0.1 GO:0033197 response to vitamin E(GO:0033197)
0.0 0.1 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.0 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.0 GO:0016048 detection of temperature stimulus(GO:0016048)
0.0 0.1 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.0 0.1 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.0 GO:0045636 positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.0 0.4 GO:0045103 intermediate filament-based process(GO:0045103)
0.0 0.1 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.0 0.1 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0 0.0 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.0 0.1 GO:0009169 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0 0.2 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.0 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.0 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.1 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.1 GO:0080111 DNA demethylation(GO:0080111)
0.0 0.0 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.2 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0 0.0 GO:0060523 prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737)
0.0 0.1 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.0 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.0 0.0 GO:0032413 negative regulation of ion transmembrane transporter activity(GO:0032413)
0.0 0.1 GO:0006188 IMP biosynthetic process(GO:0006188) IMP metabolic process(GO:0046040)
0.0 0.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.0 GO:0021563 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.1 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0 0.1 GO:0006531 aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.0 0.0 GO:0043096 adenine salvage(GO:0006168) purine nucleobase salvage(GO:0043096) adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.0 0.1 GO:0031000 response to caffeine(GO:0031000)
0.0 0.1 GO:0070874 negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.1 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065) UDP-glucuronate metabolic process(GO:0046398)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.1 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.0 GO:0048087 positive regulation of developmental pigmentation(GO:0048087)
0.0 0.0 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)
0.0 0.1 GO:0035609 C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0 0.0 GO:0060438 trachea development(GO:0060438)
0.0 0.2 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.0 GO:0046607 positive regulation of centrosome cycle(GO:0046607)
0.0 0.1 GO:0019985 translesion synthesis(GO:0019985)
0.0 0.1 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.0 0.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.0 0.1 GO:0010107 potassium ion import(GO:0010107)
0.0 0.0 GO:0010842 retina layer formation(GO:0010842)
0.0 0.1 GO:0043206 extracellular fibril organization(GO:0043206) fibril organization(GO:0097435)
0.0 0.2 GO:0031114 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.0 0.1 GO:0043113 receptor clustering(GO:0043113)
0.0 0.0 GO:0060996 dendritic spine development(GO:0060996)
0.0 0.1 GO:0090102 cochlea development(GO:0090102)
0.0 0.2 GO:0098743 cartilage condensation(GO:0001502) cell aggregation(GO:0098743)
0.0 0.0 GO:0034723 DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.0 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.0 GO:0060013 righting reflex(GO:0060013)
0.0 0.1 GO:0051299 centrosome separation(GO:0051299)
0.0 0.0 GO:0032071 regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
0.0 0.0 GO:0060913 cardiac cell fate determination(GO:0060913)
0.0 0.1 GO:0014850 response to muscle activity(GO:0014850)
0.0 0.1 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.0 GO:0010815 bradykinin catabolic process(GO:0010815)
0.0 0.0 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.0 0.0 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.0 GO:0072112 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.0 GO:0044557 relaxation of smooth muscle(GO:0044557) relaxation of vascular smooth muscle(GO:0060087)
0.0 0.1 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.0 GO:0046549 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549) camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.0 GO:0021754 facial nucleus development(GO:0021754)
0.0 0.0 GO:0072172 ureteric bud formation(GO:0060676) mesonephric tubule formation(GO:0072172)
0.0 0.2 GO:0006825 copper ion transport(GO:0006825)
0.0 0.1 GO:2000272 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) negative regulation of receptor activity(GO:2000272)
0.0 0.1 GO:0006553 lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0 0.0 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.1 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.0 0.1 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.1 GO:1903019 negative regulation of glycoprotein biosynthetic process(GO:0010561) negative regulation of glycoprotein metabolic process(GO:1903019)
0.0 0.0 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.0 0.0 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.0 0.0 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.0 0.1 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.2 GO:0030901 midbrain development(GO:0030901)
0.0 0.1 GO:0044065 regulation of respiratory gaseous exchange by neurological system process(GO:0002087) regulation of respiratory system process(GO:0044065)
0.0 0.0 GO:0015864 pyrimidine nucleoside transport(GO:0015864)
0.0 0.0 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.0 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.0 GO:0070092 glucagon secretion(GO:0070091) regulation of glucagon secretion(GO:0070092)
0.0 0.0 GO:0051549 regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0 0.1 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.0 GO:0060347 heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0 0.1 GO:0045844 positive regulation of striated muscle tissue development(GO:0045844) positive regulation of muscle organ development(GO:0048636) positive regulation of muscle tissue development(GO:1901863)
0.0 0.0 GO:0009822 alkaloid catabolic process(GO:0009822)
0.0 0.0 GO:0003283 atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0 0.1 GO:0006561 proline biosynthetic process(GO:0006561)
0.0 0.0 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.3 GO:0048146 positive regulation of fibroblast proliferation(GO:0048146)
0.0 0.1 GO:0009086 methionine biosynthetic process(GO:0009086)
0.0 0.0 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.1 GO:0009649 entrainment of circadian clock(GO:0009649)
0.0 0.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.0 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) positive regulation of calcium ion transmembrane transporter activity(GO:1901021) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341) positive regulation of cation channel activity(GO:2001259)
0.0 0.1 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.0 0.0 GO:0008356 asymmetric cell division(GO:0008356)
0.0 0.1 GO:0032876 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0 0.2 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 0.1 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.0 GO:0060027 convergent extension involved in gastrulation(GO:0060027)
0.0 0.1 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.1 GO:0045655 regulation of monocyte differentiation(GO:0045655)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.2 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.2 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.3 GO:0005587 collagen type IV trimer(GO:0005587)
0.1 0.2 GO:0043259 laminin-10 complex(GO:0043259)
0.1 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.1 0.4 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.3 GO:0071437 invadopodium(GO:0071437)
0.1 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0045298 tubulin complex(GO:0045298)
0.0 0.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.2 GO:0005916 fascia adherens(GO:0005916)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.4 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.2 GO:0030673 axolemma(GO:0030673)
0.0 0.1 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0 0.2 GO:0010369 chromocenter(GO:0010369)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.2 GO:0043205 fibril(GO:0043205)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.0 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.1 GO:0005606 laminin-1 complex(GO:0005606)
0.0 0.1 GO:0001520 outer dense fiber(GO:0001520) sperm flagellum(GO:0036126)
0.0 0.1 GO:0016580 Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822)
0.0 0.1 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.0 GO:0001652 granular component(GO:0001652)
0.0 0.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.0 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.0 GO:0071942 XPC complex(GO:0071942)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.0 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.1 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0032589 neuron projection membrane(GO:0032589)
0.0 0.0 GO:0001940 male pronucleus(GO:0001940)
0.0 0.1 GO:0038201 TOR complex(GO:0038201)
0.0 0.0 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.0 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.0 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.0 GO:0043218 compact myelin(GO:0043218)
0.0 0.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.1 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.0 0.5 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 0.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0001098 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1 0.4 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.4 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 0.3 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.5 GO:0030274 LIM domain binding(GO:0030274)
0.1 0.4 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 0.2 GO:0070052 collagen V binding(GO:0070052)
0.1 0.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.2 GO:0042805 actinin binding(GO:0042805)
0.0 0.3 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.1 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.4 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0 0.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0 0.1 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.5 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.2 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0035198 miRNA binding(GO:0035198)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.1 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.2 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 0.2 GO:0051378 serotonin binding(GO:0051378)
0.0 0.1 GO:0036137 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 0.2 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.2 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.3 GO:0043498 obsolete cell surface binding(GO:0043498)
0.0 0.1 GO:0051637 obsolete Gram-positive bacterial cell surface binding(GO:0051637)
0.0 0.4 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 0.1 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.1 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.1 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 0.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.1 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.0 0.1 GO:0015211 purine nucleoside transmembrane transporter activity(GO:0015211)
0.0 1.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.1 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.1 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 0.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.0 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.1 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.2 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.1 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.1 GO:0034711 inhibin binding(GO:0034711)
0.0 0.0 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.2 GO:0030276 clathrin binding(GO:0030276)
0.0 0.1 GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0 0.1 GO:0046870 cadmium ion binding(GO:0046870)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.1 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.1 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.1 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0 0.2 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.2 GO:0001619 obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0 0.0 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.0 0.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0030332 cyclin binding(GO:0030332)
0.0 0.0 GO:0043734 DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0 0.0 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.1 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.1 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.0 GO:0031177 phosphopantetheine binding(GO:0031177)
0.0 0.1 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.1 GO:0070717 poly-purine tract binding(GO:0070717)
0.0 0.0 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.0 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.1 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.1 GO:0003696 satellite DNA binding(GO:0003696)
0.0 0.3 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.0 GO:0004936 alpha-adrenergic receptor activity(GO:0004936)
0.0 0.0 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.0 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.1 GO:0031994 insulin-like growth factor I binding(GO:0031994)
0.0 0.1 GO:0030507 spectrin binding(GO:0030507)
0.0 0.0 GO:0043175 RNA polymerase core enzyme binding(GO:0043175)
0.0 0.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 0.0 GO:0070548 L-glutamine aminotransferase activity(GO:0070548)
0.0 0.1 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 0.0 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.0 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.1 GO:0042301 phosphate ion binding(GO:0042301)
0.0 0.0 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.0 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.2 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.0 GO:0051425 PTB domain binding(GO:0051425)
0.0 0.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.1 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.1 GO:0008312 7S RNA binding(GO:0008312)
0.0 0.1 GO:0030275 LRR domain binding(GO:0030275)
0.0 0.1 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.0 GO:0003896 DNA primase activity(GO:0003896)
0.0 0.0 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 1.1 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.0 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.1 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.0 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.5 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.1 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.0 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.1 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.1 ST ADRENERGIC Adrenergic Pathway
0.0 0.1 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.4 PID RHOA REG PATHWAY Regulation of RhoA activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME REGULATION OF APOPTOSIS Genes involved in Regulation of Apoptosis
0.0 0.5 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.9 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.4 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.0 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 1.1 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.1 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.4 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.3 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.4 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.0 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.1 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.1 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.1 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.1 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.0 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0 0.1 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor