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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ATF4

Z-value: 0.35

Motif logo

Transcription factors associated with ATF4

Gene Symbol	Gene ID	Gene Info
ATF4 Ensembl NCBI GeneCards UniProt	ENSG00000128272.10	ATF4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ATF4	chr22_39916629_39916983	237	0.900609	-0.59	9.3e-02	Click!
ATF4	chr22_39915742_39916052	197	0.920332	-0.52	1.5e-01	Click!
ATF4	chr22_39917795_39917946	1301	0.361515	-0.52	1.5e-01	Click!
ATF4	chr22_39917253_39917786	950	0.477950	-0.50	1.7e-01	Click!
ATF4	chr22_39916301_39916487	175	0.930203	-0.49	1.8e-01	Click!

Activity of the ATF4 motif across conditions

Conditions sorted by the z-value of the ATF4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr22_50919615_50920637	0.14	ADM2	adrenomedullin 2	27	0.94
chr5_153691070_153691221	0.14	ENSG00000221070	.	28541	0.16
chr3_5239428_5239587	0.12	EDEM1	ER degradation enhancer, mannosidase alpha-like 1	9473	0.15
chr1_59966766_59966917	0.11	FGGY	FGGY carbohydrate kinase domain containing	52749	0.18
chr20_43124073_43124404	0.10	SERINC3	serine incorporator 3	9294	0.12
chr13_95133005_95133156	0.10	DCT	dopachrome tautomerase	1144	0.56
chr1_234039912_234040198	0.09	SLC35F3	solute carrier family 35, member F3	624	0.81
chr19_19513882_19514033	0.09	CTB-184G21.3		545	0.68
chrX_49853365_49853516	0.09	CLCN5	chloride channel, voltage-sensitive 5	19284	0.14
chr6_88609819_88609970	0.09	ENSG00000211983	.	52544	0.13
chr8_96247980_96248131	0.08	C8orf37	chromosome 8 open reading frame 37	33374	0.2
chr13_114263460_114263611	0.08	TFDP1	transcription factor Dp-1	23794	0.17
chr4_185734510_185734661	0.08	RP11-701P16.2	Uncharacterized protein	188	0.91
chr11_20000428_20000721	0.08	NAV2-AS3	NAV2 antisense RNA 3	2309	0.36
chr11_70262295_70262446	0.07	CTTN	cortactin	3861	0.17
chr10_28031252_28032104	0.07	MKX	mohawk homeobox	796	0.61
chr1_8278863_8279147	0.07	ENSG00000200975	.	12348	0.21
chr11_70163755_70163906	0.07	CTA-797E19.1		2204	0.21
chr16_14994956_14995107	0.07	ENSG00000257264	.	334	0.79
chr19_40590982_40591133	0.07	ZNF780A	zinc finger protein 780A	5085	0.16
chr9_36144726_36145049	0.07	GLIPR2	GLI pathogenesis-related 2	8145	0.19
chr5_159510080_159510300	0.07	PWWP2A	PWWP domain containing 2A	36239	0.14
chr1_117079785_117079936	0.07	CD58	CD58 molecule	7352	0.18
chr6_121329824_121330111	0.07	ENSG00000200310	.	322200	0.01
chrX_50200272_50200423	0.07	CCNB3	cyclin B3	172807	0.03
chr11_72546027_72546178	0.06	FCHSD2	FCH and double SH3 domains 2	8456	0.14
chr12_29588619_29588770	0.06	OVCH1	ovochymase 1	8475	0.22
chr9_123495329_123495480	0.06	MEGF9	multiple EGF-like-domains 9	18656	0.21
chr1_207509019_207509170	0.06	CD55	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	13958	0.26
chr5_142373997_142374148	0.06	ARHGAP26	Rho GTPase activating protein 26	42689	0.2
chr5_52327571_52327722	0.06	CTD-2175A23.1		41538	0.14
chr2_46769122_46769585	0.06	ATP6V1E2	ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2	343	0.61
chr11_7998839_7999271	0.06	EIF3F	eukaryotic translation initiation factor 3, subunit F	7257	0.13
chr2_51447556_51447707	0.05	NRXN1	neurexin 1	187957	0.03
chr9_40632604_40633916	0.05	SPATA31A3	SPATA31 subfamily A, member 3	67031	0.14
chr10_29916878_29917029	0.05	SVIL	supervillin	6948	0.21
chr11_102096966_102097117	0.05	RP11-864G5.3		4612	0.23
chr11_35195556_35195728	0.05	CD44	CD44 molecule (Indian blood group)	2476	0.25
chr2_17774779_17774930	0.05	VSNL1	visinin-like 1	52427	0.16
chr6_24922511_24922662	0.05	FAM65B	family with sequence similarity 65, member B	11391	0.23
chr12_65131454_65131605	0.05	GNS	glucosamine (N-acetyl)-6-sulfatase	7141	0.15
chr17_60859401_60859552	0.05	MARCH10	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	22124	0.2
chr19_54327344_54327551	0.05	NLRP12	NLR family, pyrin domain containing 12	124	0.86
chr9_41432727_41433091	0.05	SPATA31A5	SPATA31 subfamily A, member 5	67770	0.13
chr8_36720546_36720697	0.05	KCNU1	potassium channel, subfamily U, member 1	65802	0.14
chr17_68166405_68166607	0.05	KCNJ2	potassium inwardly-rectifying channel, subfamily J, member 2	830	0.45
chr20_47368252_47368403	0.05	ENSG00000251876	.	12342	0.27
chr18_3597270_3597421	0.05	DLGAP1-AS1	DLGAP1 antisense RNA 1	2892	0.21
chr9_39287322_39287607	0.05	CNTNAP3	contactin associated protein-like 3	628	0.81
chrX_19700900_19701219	0.05	SH3KBP1	SH3-domain kinase binding protein 1	11943	0.3
chr21_44495024_44495938	0.05	CBS	cystathionine-beta-synthase	460	0.8
chr9_65576390_65577630	0.04	SPATA31A7	SPATA31 subfamily A, member 7	67400	0.15
chr20_61303254_61303405	0.04	SLCO4A1	solute carrier organic anion transporter family, member 4A1	4164	0.14
chr2_192058733_192058884	0.04	STAT4	signal transducer and activator of transcription 4	42486	0.15
chr9_39816703_39816854	0.04	SPATA31A2	SPATA31 subfamily A, member 2	68197	0.13
chr2_242269478_242269629	0.04	SEPT2	septin 2	5705	0.15
chr4_68303805_68303956	0.04	ENSG00000206629	.	8408	0.29
chr1_158977592_158977743	0.04	IFI16	interferon, gamma-inducible protein 16	1118	0.53
chr11_7621443_7621674	0.04	PPFIBP2	PTPRF interacting protein, binding protein 2 (liprin beta 2)	3141	0.25
chr2_87782164_87782461	0.04	RP11-1399P15.1		4759	0.34
chr11_118111552_118111703	0.04	MPZL3	myelin protein zero-like 3	11435	0.13
chr1_232756314_232756465	0.04	SIPA1L2	signal-induced proliferation-associated 1 like 2	59085	0.14
chr3_39372377_39372528	0.04	CCR8	chemokine (C-C motif) receptor 8	1188	0.47
chr3_10231782_10231933	0.04	IRAK2	interleukin-1 receptor-associated kinase 2	25308	0.1
chr19_31807183_31807454	0.04	AC007796.1		32469	0.2
chr5_53736380_53736531	0.04	HSPB3	heat shock 27kDa protein 3	14990	0.27
chr15_31727307_31728004	0.04	KLF13	Kruppel-like factor 13	69298	0.13
chr1_78392239_78392485	0.04	NEXN	nexilin (F actin binding protein)	8549	0.18
chr3_111260963_111261300	0.04	CD96	CD96 molecule	134	0.97
chr22_22417650_22417801	0.04	IGLVV-66	immunoglobulin lambda variable (V)-66 (pseudogene)	2236	0.12
chr15_86099150_86099301	0.04	AKAP13	A kinase (PRKA) anchor protein 13	548	0.77
chr2_197071722_197071873	0.04	ENSG00000239161	.	8249	0.2
chr17_29645268_29645505	0.04	CTD-2370N5.3		272	0.86
chr12_57349520_57349671	0.04	RDH16	retinol dehydrogenase 16 (all-trans)	2508	0.18
chr1_29254208_29254684	0.04	EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	13355	0.18
chr8_1968982_1969133	0.04	MYOM2	myomesin 2	24098	0.23
chr16_16393606_16393757	0.04	ENSG00000257381	.	335	0.78
chr9_22006120_22006693	0.04	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	2546	0.22
chr5_54456050_54456451	0.03	GPX8	glutathione peroxidase 8 (putative)	252	0.86
chr15_66662520_66662887	0.03	TIPIN	TIMELESS interacting protein	13649	0.11
chr13_46870401_46870552	0.03	ENSG00000252854	.	46399	0.12
chr1_52520143_52521733	0.03	TXNDC12	thioredoxin domain containing 12 (endoplasmic reticulum)	75	0.92
chr14_55769874_55770025	0.03	FBXO34	F-box protein 34	31077	0.17
chr1_186782436_186782587	0.03	PLA2G4A	phospholipase A2, group IVA (cytosolic, calcium-dependent)	15574	0.29
chr7_98000760_98000949	0.03	BAIAP2L1	BAI1-associated protein 2-like 1	29526	0.17
chr10_14799506_14799657	0.03	FAM107B	family with sequence similarity 107, member B	17315	0.21
chr11_34393219_34393432	0.03	ABTB2	ankyrin repeat and BTB (POZ) domain containing 2	13770	0.25
chr14_80296454_80296605	0.03	RP11-242P2.1		38923	0.23
chrX_12974492_12974668	0.03	TMSB4X	thymosin beta 4, X-linked	18647	0.19
chr13_30168298_30169638	0.03	SLC7A1	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	857	0.74
chr8_49831086_49831370	0.03	SNAI2	snail family zinc finger 2	2760	0.41
chr15_55695695_55695873	0.03	CCPG1	cell cycle progression 1	4466	0.19
chr3_171805158_171805309	0.03	FNDC3B	fibronectin type III domain containing 3B	39531	0.2
chr1_160611300_160611550	0.03	SLAMF1	signaling lymphocytic activation molecule family member 1	5386	0.18
chr10_65227518_65227669	0.03	JMJD1C	jumonji domain containing 1C	1871	0.34
chr19_10865922_10866073	0.03	ENSG00000265879	.	24933	0.1
chr7_115912354_115912783	0.03	TES	testis derived transcript (3 LIM domains)	22079	0.19
chr20_23238774_23238931	0.03	NXT1	NTF2-like export factor 1	92521	0.05
chr16_85558650_85558942	0.03	ENSG00000264203	.	83698	0.08
chr17_45743155_45743306	0.03	KPNB1	karyopherin (importin) beta 1	2501	0.2
chr6_54063055_54063206	0.03	MLIP	muscular LMNA-interacting protein	86822	0.09
chr5_126097836_126098030	0.03	ENSG00000252185	.	6824	0.23
chr6_41168130_41168571	0.03	TREML2	triggering receptor expressed on myeloid cells-like 2	582	0.65
chr1_244816518_244817656	0.03	DESI2	desumoylating isopeptidase 2	34	0.98
chr12_8608652_8608803	0.03	CLEC6A	C-type lectin domain family 6, member A	205	0.93
chr22_17599343_17599494	0.03	CECR6	cat eye syndrome chromosome region, candidate 6	2725	0.2
chr5_131795223_131795415	0.03	ENSG00000202533	.	8520	0.13
chr4_74587190_74587341	0.03	IL8	interleukin 8	18958	0.22
chr8_126590914_126591065	0.03	ENSG00000266452	.	134182	0.05
chr4_15680427_15680704	0.03	FBXL5	F-box and leucine-rich repeat protein 5	2612	0.25
chr17_38498589_38499681	0.03	CTD-2267D19.2		253	0.69
chr1_164717921_164718072	0.03	PBX1	pre-B-cell leukemia homeobox 1	24153	0.17
chr9_110310779_110311295	0.03	KLF4	Kruppel-like factor 4 (gut)	58274	0.13
chrX_110339181_110339857	0.03	PAK3	p21 protein (Cdc42/Rac)-activated kinase 3	69	0.99
chr20_19052062_19052213	0.03	ENSG00000264669	.	54292	0.15
chrX_9431281_9431551	0.03	TBL1X	transducin (beta)-like 1X-linked	45	0.99
chr10_63995828_63995979	0.03	RTKN2	rhotekin 2	119	0.98
chr15_51172886_51173037	0.03	AP4E1	adaptor-related protein complex 4, epsilon 1 subunit	27909	0.22
chr18_13464907_13465379	0.02	LDLRAD4	low density lipoprotein receptor class A domain containing 4	129	0.93
chr3_58321087_58321238	0.02	PXK	PX domain containing serine/threonine kinase	2129	0.32
chr2_54517166_54517317	0.02	TSPYL6	TSPY-like 6	33832	0.18
chr1_154130279_154130430	0.02	NUP210L	nucleoporin 210kDa-like	2762	0.15
chr11_47241983_47242228	0.02	RP11-17G12.2		1197	0.29
chr9_117657275_117657426	0.02	TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	35347	0.2
chr12_67928012_67928180	0.02	DYRK2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	114022	0.07
chr1_43036666_43036817	0.02	ENSG00000200254	.	2037	0.33
chr10_97624941_97625092	0.02	RP11-429G19.3		31751	0.15
chr9_107826999_107827201	0.02	ENSG00000201583	.	31937	0.22
chr6_163730438_163730589	0.02	ENSG00000239136	.	82571	0.1
chr18_41514870_41515021	0.02	ENSG00000202250	.	102715	0.08
chr20_14985685_14985836	0.02	ENSG00000199803	.	16545	0.2
chr3_62573316_62573467	0.02	CADPS	Ca++-dependent secretion activator	2470	0.43
chr2_30695318_30695469	0.02	LCLAT1	lysocardiolipin acyltransferase 1	25124	0.22
chr9_110377598_110377749	0.02	ENSG00000202308	.	47854	0.17
chr4_40731755_40731906	0.02	NSUN7	NOP2/Sun domain family, member 7	20084	0.21
chr3_33687128_33687279	0.02	CLASP2	cytoplasmic linker associated protein 2	208	0.97
chr2_225543043_225543293	0.02	CUL3	cullin 3	93058	0.09
chr13_40889454_40889605	0.02	ENSG00000207458	.	88565	0.09
chr14_60239555_60239706	0.02	RTN1	reticulon 1	98054	0.07
chr1_212781685_212782134	0.02	ATF3	activating transcription factor 3	103	0.96
chr10_90031525_90031822	0.02	ENSG00000200891	.	277221	0.01
chr19_47134901_47135052	0.02	GNG8	guanine nucleotide binding protein (G protein), gamma 8	2966	0.12
chr16_9166928_9167149	0.02	C16orf72	chromosome 16 open reading frame 72	18467	0.16
chr8_25058747_25058898	0.02	DOCK5	dedicator of cytokinesis 5	16442	0.23
chr3_179754024_179754473	0.02	PEX5L	peroxisomal biogenesis factor 5-like	310	0.94
chr18_72235350_72235501	0.02	RP11-231E4.3		6090	0.21
chr14_95991348_95991499	0.02	ENSG00000252481	.	8543	0.14
chr19_1259849_1260000	0.02	CIRBP	cold inducible RNA binding protein	540	0.56
chr17_53573866_53574017	0.02	ENSG00000200107	.	55230	0.15
chr15_89181571_89183025	0.02	ISG20	interferon stimulated exonuclease gene 20kDa	114	0.96
chr5_139680846_139680997	0.02	PFDN1	prefoldin subunit 1	1747	0.3
chr2_85972153_85972528	0.02	ATOH8	atonal homolog 8 (Drosophila)	8677	0.15
chr8_61021784_61021935	0.02	CA8	carbonic anhydrase VIII	172112	0.04
chr21_34712478_34712629	0.02	IFNAR1	interferon (alpha, beta and omega) receptor 1	15275	0.17
chr17_4802345_4802927	0.02	C17orf107	chromosome 17 open reading frame 107	77	0.92
chr12_47617851_47618002	0.02	PCED1B	PC-esterase domain containing 1B	598	0.78
chr8_35828319_35828470	0.02	AC012215.1	Uncharacterized protein	179029	0.03
chr3_71115813_71116298	0.02	FOXP1	forkhead box P1	1137	0.67
chr7_75575266_75575417	0.02	POR	P450 (cytochrome) oxidoreductase	701	0.6
chr4_185235485_185235636	0.02	ENSG00000244512	.	35471	0.16
chr16_88271666_88271817	0.02	ZNF469	zinc finger protein 469	222138	0.02
chrX_53117609_53118006	0.02	TSPYL2	TSPY-like 2	6244	0.19
chr11_11418436_11418587	0.02	CSNK2A3	casein kinase 2, alpha 3 polypeptide	43607	0.17
chr8_130957137_130957288	0.02	FAM49B	family with sequence similarity 49, member B	5094	0.24
chr21_42217900_42218266	0.02	DSCAM	Down syndrome cell adhesion molecule	982	0.71
chr19_47843854_47844005	0.02	C5AR2	complement component 5a receptor 2	111	0.95
chr6_134323821_134323972	0.02	TBPL1	TBP-like 1	49534	0.14
chr9_104207627_104207869	0.02	ALDOB	aldolase B, fructose-bisphosphate	9643	0.15
chr8_23456525_23456676	0.02	ENSG00000252067	.	1051	0.5
chr10_54463336_54463751	0.02	RP11-556E13.1		51626	0.16
chr3_30014109_30014328	0.02	RBMS3-AS1	RBMS3 antisense RNA 1	38571	0.22
chr10_112676510_112676710	0.02	BBIP1	BBSome interacting protein 1	2084	0.21
chr10_90358006_90358157	0.02	LIPJ	lipase, family member J	3578	0.22
chrX_15806325_15806476	0.02	ZRSR2	zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2	2195	0.32
chrX_121981496_121981647	0.02	ENSG00000212321	.	7292	0.34
chr3_149371362_149371801	0.02	WWTR1-AS1	WWTR1 antisense RNA 1	3226	0.2
chr5_75764900_75765051	0.02	IQGAP2	IQ motif containing GTPase activating protein 2	64726	0.13
chr11_77185235_77185792	0.02	PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	167	0.92
chr12_65032414_65032565	0.02	RP11-338E21.2		10365	0.12
chr4_188049686_188049901	0.02	ENSG00000252382	.	271183	0.02
chr11_14310125_14310327	0.02	RRAS2	related RAS viral (r-ras) oncogene homolog 2	7179	0.24
chr20_30793303_30793454	0.02	PLAGL2	pleiomorphic adenoma gene-like 2	2216	0.22
chr8_127569289_127570002	0.02	RP11-89K10.1		475	0.43
chr17_14680546_14680697	0.02	ENSG00000238806	.	460579	0.01
chr3_3843603_3843999	0.02	LRRN1	leucine rich repeat neuronal 1	2680	0.43
chr21_43739991_43740142	0.02	TFF3	trefoil factor 3 (intestinal)	4305	0.17
chr16_69363414_69364502	0.02	PDF	peptide deformylase (mitochondrial)	540	0.59
chr11_75473950_75474101	0.02	DGAT2	diacylglycerol O-acyltransferase 2	3468	0.13
chr17_70358508_70358679	0.02	SOX9	SRY (sex determining region Y)-box 9	241432	0.02
chr4_154064855_154065006	0.02	TRIM2	tripartite motif containing 2	8715	0.28
chr12_68661800_68661951	0.02	IL22	interleukin 22	14488	0.21
chr6_5936596_5936747	0.02	ENSG00000239472	.	17594	0.25
chr9_21563269_21563420	0.02	MIR31HG	MIR31 host gene (non-protein coding)	3676	0.23
chr9_3508436_3508948	0.02	RFX3	regulatory factor X, 3 (influences HLA class II expression)	17291	0.25
chrX_135258076_135258227	0.02	FHL1	four and a half LIM domains 1	6066	0.24
chr3_146272331_146272482	0.02	PLSCR1	phospholipid scramblase 1	9755	0.18
chrX_24043946_24044693	0.02	KLHL15	kelch-like family member 15	984	0.59
chr7_6481952_6482201	0.02	DAGLB	diacylglycerol lipase, beta	5487	0.18
chr9_32741891_32742042	0.02	ENSG00000221696	.	22328	0.18
chr1_198227931_198228157	0.02	NEK7	NIMA-related kinase 7	38115	0.23