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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for ATF7

Z-value: 0.82

Motif logo

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Transcription factors associated with ATF7

Gene Symbol Gene ID Gene Info
ATF7
ENSG00000170653.14 activating transcription factor 7

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr12_53954959_53955110ATF7397710.088898-0.665.5e-02Click!
chr12_53985363_53985546ATF793510.153411-0.627.4e-02Click!
chr12_54019958_54020201ATF7680.7971290.627.4e-02Click!
chr12_54020323_54020579ATF72520.7830180.599.7e-02Click!
chr12_53985687_53985890ATF790170.154243-0.551.2e-01Click!

Activity of the ATF7 motif across conditions

Conditions sorted by the z-value of the ATF7 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr8_21967077_21967500 0.65 NUDT18
 nudix (nucleoside diphosphate linked moiety X)-type motif 18
 356
 0.79
chr5_176881613_176881764 0.63 PRR7
 proline rich 7 (synaptic)
 6353
 0.1
chr2_28582064_28582304 0.55 FOSL2
 FOS-like antigen 2
 33485
 0.14
chr19_51014778_51015051 0.50 JOSD2
 Josephin domain containing 2
 304
 0.8
chr20_16926810_16926961 0.48 ENSG00000212165
 .
 36793
 0.22
chr16_31142045_31142196 0.42 RP11-388M20.2
634
 0.42
chr17_4046800_4047053 0.40 CYB5D2
 cytochrome b5 domain containing 2
 70
 0.9
chr12_56521312_56521715 0.39 ESYT1
 extended synaptotagmin-like protein 1
 327
 0.64
chr19_17666323_17666474 0.39 COLGALT1
 collagen beta(1-O)galactosyltransferase 1
 5
 0.96
chr19_8454704_8454922 0.36 RAB11B
 RAB11B, member RAS oncogene family
 52
 0.65
chr20_19915434_19915955 0.36 RIN2
 Ras and Rab interactor 2
 45484
 0.16
chr4_15721295_15721446 0.35 BST1
 bone marrow stromal cell antigen 1
 4419
 0.23
chr6_91006489_91006667 0.35 BACH2
 BTB and CNC homology 1, basic leucine zipper transcription factor 2
 49
 0.98
chr5_73730259_73730491 0.33 ENSG00000244326
 .
 116564
 0.06
chr20_34203605_34204165 0.33 SPAG4
 sperm associated antigen 4
 71
 0.95
chr9_95895594_95896005 0.32 NINJ1
 ninjurin 1
 771
 0.63
chr9_137347969_137348661 0.32 RXRA
 retinoid X receptor, alpha
 49887
 0.15
chr2_74781498_74781793 0.30 DOK1
 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
 213
 0.73
chr16_86817661_86817812 0.30 FOXL1
 forkhead box L1
 205621
 0.02
chr19_42900892_42901243 0.29 LIPE-AS1
 LIPE antisense RNA 1
 213
 0.88
chr19_46009815_46010009 0.29 VASP
 vasodilator-stimulated phosphoprotein
 75
 0.95
chr11_18720267_18720541 0.29 TMEM86A
 transmembrane protein 86A
 66
 0.96
chr14_103988458_103988873 0.29 CKB
 creatine kinase, brain
 368
 0.73
chr21_46898660_46898949 0.28 COL18A1
 collagen, type XVIII, alpha 1
 11385
 0.19
chr10_99078775_99079092 0.28 FRAT1
 frequently rearranged in advanced T-cell lymphomas
 89
 0.95
chr1_228353838_228353989 0.28 IBA57
 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
 397
 0.6
chr17_18528902_18529084 0.28 CCDC144B
 coiled-coil domain containing 144B (pseudogene)
 72
 0.96
chr2_8144573_8144775 0.28 ENSG00000221255
 .
 427702
 0.01
chr10_105728102_105728505 0.27 SLK
 STE20-like kinase
 1344
 0.4
chr3_170075366_170075517 0.27 SKIL
 SKI-like oncogene
 62
 0.98
chr1_228356433_228356584 0.27 IBA57
 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
 2992
 0.14
chr7_38217813_38218059 0.26 STARD3NL
 STARD3 N-terminal like
 17
 0.99
chr18_2654684_2655529 0.26 SMCHD1
 structural maintenance of chromosomes flexible hinge domain containing 1
 631
 0.67
chr8_145555468_145555619 0.25 SCRT1
 scratch family zinc finger 1
 4400
 0.08
chr22_42228451_42228869 0.25 SREBF2
 sterol regulatory element binding transcription factor 2
 449
 0.71
chr9_35617185_35617463 0.24 CD72
 CD72 molecule
 1043
 0.3
chr11_110168760_110168911 0.24 RDX
 radixin
 1388
 0.59
chr5_170739718_170739894 0.24 TLX3
 T-cell leukemia homeobox 3
 3518
 0.22
chr4_159131007_159131158 0.24 TMEM144
 transmembrane protein 144
 264
 0.91
chr19_55919228_55919426 0.24 UBE2S
 ubiquitin-conjugating enzyme E2S
 182
 0.86
chr16_85045097_85045598 0.24 ZDHHC7
 zinc finger, DHHC-type containing 7
 206
 0.95
chr22_51059513_51059819 0.23 ARSA
 arylsulfatase A
 6917
 0.1
chr15_59658629_59658780 0.23 FAM81A
 family with sequence similarity 81, member A
 6188
 0.13
chr8_33422545_33422696 0.23 RNF122
 ring finger protein 122
 2023
 0.25
chr16_88859439_88859692 0.22 PIEZO1
 piezo-type mechanosensitive ion channel component 1
 7946
 0.09
chr5_107005011_107005570 0.22 EFNA5
 ephrin-A5
 1038
 0.67
chr11_82782830_82782981 0.22 RAB30
 RAB30, member RAS oncogene family
 3
 0.98
chr11_108535331_108535645 0.22 DDX10
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
 264
 0.95
chr16_31471330_31471687 0.22 ARMC5
 armadillo repeat containing 5
 226
 0.67
chr2_43822335_43823890 0.21 THADA
 thyroid adenoma associated
 1
 0.98
chr20_12990547_12990774 0.21 SPTLC3
 serine palmitoyltransferase, long chain base subunit 3
 663
 0.83
chr17_6926858_6927139 0.20 BCL6B
 B-cell CLL/lymphoma 6, member B
 202
 0.83
chr6_36524849_36525000 0.20 STK38
 serine/threonine kinase 38
 9677
 0.14
chr14_69260124_69260503 0.20 ZFP36L1
 ZFP36 ring finger protein-like 1
 356
 0.9
chr21_45209367_45209684 0.20 RRP1
 ribosomal RNA processing 1
 131
 0.95
chr22_36519910_36520146 0.20 APOL3
 apolipoprotein L, 3
 36803
 0.17
chr3_182512816_182512967 0.20 ATP11B
 ATPase, class VI, type 11B
 1600
 0.36
chr11_33183160_33183580 0.20 CSTF3-AS1
 CSTF3 antisense RNA 1 (head to head)
 136
 0.7
chr12_71833497_71833776 0.20 LGR5
 leucine-rich repeat containing G protein-coupled receptor 5
 86
 0.97
chr7_4764745_4765032 0.20 FOXK1
 forkhead box K1
 15602
 0.18
chr2_108994212_108994393 0.20 SULT1C4
 sulfotransferase family, cytosolic, 1C, member 4
 166
 0.96
chr17_2496882_2497033 0.20 PAFAH1B1
 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
 83
 0.97
chr1_17630726_17630943 0.19 PADI4
 peptidyl arginine deiminase, type IV
 3856
 0.2
chr14_55738060_55738282 0.19 FBXO34
 F-box protein 34
 150
 0.97
chr9_130860266_130860759 0.19 SLC25A25
 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
 71
 0.93
chr15_89905376_89905703 0.19 ENSG00000207819
 .
 5709
 0.19
chr19_45349520_45349839 0.19 PVRL2
 poliovirus receptor-related 2 (herpesvirus entry mediator B)
 104
 0.94
chr9_139117671_139117822 0.19 QSOX2
 quiescin Q6 sulfhydryl oxidase 2
 1023
 0.52
chr12_120729731_120730139 0.19 ENSG00000202538
 .
 229
 0.83
chr7_27232397_27232921 0.19 HOXA11-AS
 HOXA11 antisense RNA
 5221
 0.07
chr20_15773685_15773836 0.18 MACROD2
 MACRO domain containing 2
 69690
 0.14
chr22_35805907_35806058 0.18 MCM5
 minichromosome maintenance complex component 5
 9558
 0.2
chr6_159519573_159519904 0.18 TAGAP
 T-cell activation RhoGTPase activating protein
 53554
 0.11
chr1_234176768_234176919 0.18 RP11-488L4.1
89990
 0.09
chr9_34665613_34666108 0.18 RP11-195F19.5
 HCG2040265, isoform CRA_a; Uncharacterized protein; cDNA FLJ50015
 165
 0.52
chr1_155292308_155292690 0.18 RUSC1-AS1
 RUSC1 antisense RNA 1
 1164
 0.22
chr17_7165860_7166195 0.18 CLDN7
 claudin 7
 230
 0.78
chr8_39043803_39043954 0.18 ADAM32
 ADAM metallopeptidase domain 32
 78403
 0.1
chr10_106089117_106089268 0.18 ITPRIP
 inositol 1,4,5-trisphosphate receptor interacting protein
 510
 0.71
chr1_38465984_38466787 0.18 FHL3
 four and a half LIM domains 3
 4792
 0.14
chr5_112849172_112849403 0.17 YTHDC2
 YTH domain containing 2
 93
 0.97
chr6_3157575_3157860 0.17 TUBB2A
 tubulin, beta 2A class IIa
 43
 0.97
chr16_70730957_70731108 0.17 VAC14
 Vac14 homolog (S. cerevisiae)
 1536
 0.32
chr21_44597084_44597458 0.17 CRYAA
 crystallin, alpha A
 7005
 0.17
chr3_120277883_120278034 0.17 NDUFB4
 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
 37198
 0.19
chr9_94710782_94711296 0.17 ROR2
 receptor tyrosine kinase-like orphan receptor 2
 123
 0.98
chr8_13129460_13129611 0.17 DLC1
 deleted in liver cancer 1
 4520
 0.3
chr2_138880085_138880236 0.17 HNMT
 histamine N-methyltransferase
 158117
 0.04
chr12_54378782_54378933 0.17 HOXC10
 homeobox C10
 8
 0.71
chr3_29228940_29229091 0.17 RBMS3
 RNA binding motif, single stranded interacting protein 3
 93458
 0.09
chr19_1021594_1021873 0.16 ENSG00000207357
 .
 212
 0.73
chr3_33759550_33759763 0.16 CLASP2
 cytoplasmic linker associated protein 2
 115
 0.98
chrX_54665940_54666267 0.16 GNL3L
 guanine nucleotide binding protein-like 3 (nucleolar)-like
 109428
 0.06
chr2_238609518_238609709 0.16 LRRFIP1
 leucine rich repeat (in FLII) interacting protein 1
 8631
 0.24
chr16_87896068_87896219 0.16 SLC7A5
 solute carrier family 7 (amino acid transporter light chain, L system), member 5
 1102
 0.49
chr7_100209432_100209679 0.16 MOSPD3
 motile sperm domain containing 3
 170
 0.88
chr16_49737112_49737263 0.16 ENSG00000221134
 .
 24056
 0.21
chr16_12086577_12086728 0.15 RP11-166B2.7
14945
 0.11
chrX_98854100_98854251 0.15 ENSG00000252430
 .
 213901
 0.03
chr2_64957643_64958616 0.15 ENSG00000253082
 .
 45109
 0.14
chr17_36740988_36741255 0.15 CTB-58E17.2
16181
 0.13
chr19_39175153_39175304 0.15 CTB-186G2.4
9018
 0.12
chr6_44355057_44355355 0.15 CDC5L
 cell division cycle 5-like
 56
 0.97
chr1_169863342_169863522 0.15 SCYL3
 SCY1-like 3 (S. cerevisiae)
 24
 0.98
chr19_2956542_2956693 0.15 ZNF77
 zinc finger protein 77
 11686
 0.12
chr7_140396423_140396944 0.15 NDUFB2
 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
 105
 0.63
chr12_7282858_7283009 0.14 RP11-273B20.1
85
 0.56
chr18_74205501_74206173 0.14 ZNF516
 zinc finger protein 516
 1309
 0.32
chr1_212963145_212963296 0.14 NSL1
 NSL1, MIS12 kinetochore complex component
 1703
 0.3
chr20_3782117_3782268 0.14 CDC25B
 cell division cycle 25B
 5114
 0.13
chr4_170580994_170582031 0.14 CLCN3
 chloride channel, voltage-sensitive 3
 299
 0.93
chr19_55574631_55574782 0.14 RDH13
 retinol dehydrogenase 13 (all-trans/9-cis)
 162
 0.91
chr20_56293559_56293931 0.14 PMEPA1
 prostate transmembrane protein, androgen induced 1
 7204
 0.28
chr8_135844464_135844657 0.14 ENSG00000199153
 .
 27372
 0.21
chr1_29213318_29213476 0.14 EPB41
 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
 206
 0.93
chr1_145396692_145396864 0.14 ENSG00000201558
 .
 14021
 0.13
chr1_22379888_22380679 0.14 CDC42
 cell division cycle 42
 493
 0.71
chr3_101405604_101405866 0.14 RPL24
 ribosomal protein L24
 109
 0.94
chr11_118122819_118123419 0.14 MPZL3
 myelin protein zero-like 3
 54
 0.96
chr5_130971941_130972134 0.14 RAPGEF6
 Rap guanine nucleotide exchange factor (GEF) 6
 1108
 0.65
chr12_27939182_27939333 0.14 RP11-860B13.1
5257
 0.13
chr1_181056884_181057035 0.13 IER5
 immediate early response 5
 679
 0.74
chr3_184053679_184053952 0.13 FAM131A
 family with sequence similarity 131, member A
 82
 0.94
chr6_27832819_27832970 0.13 HIST1H2AL
 histone cluster 1, H2al
 140
 0.87
chr20_34203389_34203540 0.13 SPAG4
 sperm associated antigen 4
 350
 0.8
chr17_79093601_79093928 0.13 ENSG00000207736
 .
 5409
 0.1
chr7_96634662_96635012 0.13 DLX6
 distal-less homeobox 6
 23
 0.95
chr8_142275255_142276084 0.13 RP11-10J21.3
 Uncharacterized protein
 11005
 0.14
chr8_69155638_69155789 0.13 ENSG00000252210
 .
 20076
 0.25
chr19_6393244_6393475 0.13 GTF2F1
 general transcription factor IIF, polypeptide 1, 74kDa
 112
 0.91
chr3_31577931_31578214 0.13 STT3B
 STT3B, subunit of the oligosaccharyltransferase complex (catalytic)
 3790
 0.36
chr14_74352825_74353319 0.13 ZNF410
 zinc finger protein 410
 248
 0.86
chr19_10974082_10974233 0.13 CARM1
 coactivator-associated arginine methyltransferase 1
 8032
 0.12
chr4_77875208_77875359 0.13 SEPT11
 septin 11
 4268
 0.27
chr8_145561219_145561461 0.13 SCRT1
 scratch family zinc finger 1
 1397
 0.19
chr6_28864112_28865009 0.12 HCG14
 HLA complex group 14 (non-protein coding)
 253
 0.89
chr14_63749678_63749829 0.12 ENSG00000265711
 .
 50223
 0.15
chr2_47403720_47403910 0.12 CALM2
 calmodulin 2 (phosphorylase kinase, delta)
 75
 0.98
chr8_142180071_142180222 0.12 DENND3
 DENN/MADD domain containing 3
 8074
 0.2
chr8_74792637_74792788 0.12 UBE2W
 ubiquitin-conjugating enzyme E2W (putative)
 1567
 0.43
chr7_151696730_151696881 0.12 GALNT11
 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
 25973
 0.14
chr19_13056278_13056490 0.12 RAD23A
 RAD23 homolog A (S. cerevisiae)
 285
 0.69
chr17_58603607_58603878 0.12 RP11-15E18.1
82
 0.61
chr21_16665827_16665978 0.12 NRIP1
 nuclear receptor interacting protein 1
 228581
 0.02
chr2_78182087_78182238 0.12 LRRTM4
 leucine rich repeat transmembrane neuronal 4
 361840
 0.01
chr21_43619409_43619560 0.12 ABCG1
 ATP-binding cassette, sub-family G (WHITE), member 1
 315
 0.9
chr11_13238316_13238540 0.12 ARNTL
 aryl hydrocarbon receptor nuclear translocator-like
 59771
 0.15
chr13_110383367_110383518 0.12 LINC00676
 long intergenic non-protein coding RNA 676
 2813
 0.38
chr10_63779003_63779237 0.11 ARID5B
 AT rich interactive domain 5B (MRF1-like)
 29850
 0.22
chr16_68056878_68057148 0.11 DUS2
 dihydrouridine synthase 2
 143
 0.85
chr1_153917120_153917271 0.11 DENND4B
 DENN/MADD domain containing 4B
 550
 0.58
chr8_41625594_41625745 0.11 ANK1
 ankyrin 1, erythrocytic
 29471
 0.15
chr1_28655191_28655470 0.11 MED18
 mediator complex subunit 18
 219
 0.92
chr12_123201117_123201268 0.11 HCAR3
 hydroxycarboxylic acid receptor 3
 247
 0.89
chr11_77113152_77113303 0.11 PAK1
 p21 protein (Cdc42/Rac)-activated kinase 1
 9722
 0.24
chr13_32889728_32890299 0.11 BRCA2
 breast cancer 2, early onset
 371
 0.59
chr12_25538523_25539010 0.11 ENSG00000201439
 .
 18596
 0.25
chr22_39745318_39745552 0.11 SYNGR1
 synaptogyrin 1
 495
 0.71
chr2_41495595_41495746 0.11 ENSG00000221372
 .
 327856
 0.01
chr11_1404301_1404651 0.11 BRSK2
 BR serine/threonine kinase 2
 6653
 0.2
chr18_21573835_21574026 0.11 TTC39C
 tetratricopeptide repeat domain 39C
 1193
 0.47
chr17_75197356_75197507 0.11 SEC14L1
 SEC14-like 1 (S. cerevisiae)
 5466
 0.24
chr14_100112036_100112187 0.11 HHIPL1
 HHIP-like 1
 631
 0.72
chrX_152337908_152338131 0.11 PNMA6A
 paraneoplastic Ma antigen family member 6A
 282
 0.91
chr22_26875322_26876099 0.11 HPS4
 Hermansky-Pudlak syndrome 4
 63
 0.96
chr16_2563812_2564354 0.10 ATP6V0C
 ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
 106
 0.49
chr1_167569579_167569730 0.10 RCSD1
 RCSD domain containing 1
 29676
 0.15
chr17_4643181_4643351 0.10 CXCL16
 chemokine (C-X-C motif) ligand 16
 49
 0.49
chr1_91183266_91183570 0.10 BARHL2
 BarH-like homeobox 2
 624
 0.83
chr3_122513577_122513821 0.10 DIRC2
 disrupted in renal carcinoma 2
 57
 0.95
chr16_27378896_27379134 0.10 IL4R
 interleukin 4 receptor
 15019
 0.19
chrX_57931578_57932092 0.10 ZXDA
 zinc finger, X-linked, duplicated A
 5232
 0.36
chr1_161495345_161495496 0.10 HSPA6
 heat shock 70kDa protein 6 (HSP70B')
 1384
 0.32
chr11_66383426_66383834 0.10 RBM14
 RNA binding motif protein 14
 423
 0.31
chr10_71991819_71992862 0.10 PPA1
 pyrophosphatase (inorganic) 1
 820
 0.66
chr1_47060765_47060916 0.10 MKNK1
 MAP kinase interacting serine/threonine kinase 1
 109
 0.96
chr16_70456934_70457085 0.10 ST3GAL2
 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
 15982
 0.11
chr1_212781685_212782134 0.10 ATF3
 activating transcription factor 3
 103
 0.96
chr6_144671797_144672109 0.10 UTRN
 utrophin
 6716
 0.26
chr17_60970209_60970370 0.10 ENSG00000207552
 .
 51287
 0.14
chr1_202977767_202977918 0.10 TMEM183A
 transmembrane protein 183A
 1328
 0.33
chr22_22020368_22020729 0.10 PPIL2
 peptidylprolyl isomerase (cyclophilin)-like 2
 190
 0.88
chr16_3137327_3137594 0.09 ENSG00000200204
 .
 1316
 0.18
chr18_29542335_29542486 0.09 TRAPPC8
 trafficking protein particle complex 8
 19341
 0.14
chr1_63787954_63788471 0.09 RP4-792G4.2
83
 0.88
chr3_16328270_16328443 0.09 OXNAD1
 oxidoreductase NAD-binding domain containing 1
 17608
 0.16
chr9_100565675_100565842 0.09 FOXE1
 forkhead box E1 (thyroid transcription factor 2)
 49778
 0.12
chr1_98569638_98569861 0.09 ENSG00000225206
 .
 58022
 0.17
chr14_89771641_89771801 0.09 RP11-356K23.1
44908
 0.14
chr20_62580551_62580702 0.09 UCKL1
 uridine-cytidine kinase 1-like 1
 1853
 0.14
chr10_111970982_111971381 0.09 MXI1
 MAX interactor 1, dimerization protein
 1192
 0.49
chr9_24621401_24621552 0.09 IZUMO3
 IZUMO family member 3
 75532
 0.13
chr7_6388445_6388661 0.09 FAM220A
 family with sequence similarity 220, member A
 37
 0.98
chr16_89307892_89308107 0.09 RP11-46C24.6
12899
 0.11
chr15_101733614_101733826 0.09 CHSY1
 chondroitin sulfate synthase 1
 58417
 0.11
chr1_235489879_235490582 0.09 GGPS1
 geranylgeranyl diphosphate synthase 1
 435
 0.56
chr1_244210323_244211450 0.09 ZBTB18
 zinc finger and BTB domain containing 18
 3699
 0.27
chr3_154041274_154042558 0.09 DHX36
 DEAH (Asp-Glu-Ala-His) box polypeptide 36
 289
 0.93
chr3_30645783_30645934 0.09 TGFBR2
 transforming growth factor, beta receptor II (70/80kDa)
 2136
 0.46
chr12_116703907_116704375 0.09 ENSG00000263768
 .
 10348
 0.21

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0021819 layer formation in cerebral cortex(GO:0021819)
0.1 0.2 GO:0030644 cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.1 0.3 GO:0070208 protein heterotrimerization(GO:0070208)
0.1 0.2 GO:0048388 endosomal lumen acidification(GO:0048388)
0.1 0.2 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 0.2 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.1 0.2 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.1 0.2 GO:0035519 protein K29-linked ubiquitination(GO:0035519)
0.0 0.2 GO:0032933 SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.2 GO:0046520 sphingoid biosynthetic process(GO:0046520)
0.0 0.1 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0 0.1 GO:0048087 positive regulation of developmental pigmentation(GO:0048087)
0.0 0.1 GO:0015917 aminophospholipid transport(GO:0015917)
0.0 0.1 GO:0021554 optic nerve development(GO:0021554)
0.0 0.1 GO:0048478 replication fork protection(GO:0048478)
0.0 0.1 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.1 GO:0031269 pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.1 GO:0000089 mitotic metaphase(GO:0000089)
0.0 0.0 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.0 0.1 GO:0018101 protein citrullination(GO:0018101)
0.0 0.2 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.1 GO:0006670 sphingosine metabolic process(GO:0006670)
0.0 0.2 GO:0031290 retinal ganglion cell axon guidance(GO:0031290)
0.0 0.2 GO:0051923 sulfation(GO:0051923)
0.0 0.0 GO:0060437 lung growth(GO:0060437)
0.0 0.0 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.0 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.0 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0 0.0 GO:0032203 telomere formation via telomerase(GO:0032203)
0.0 0.1 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.0 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.1 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.0 0.0 GO:0002887 negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.0 0.0 GO:0070309 lens fiber cell morphogenesis(GO:0070309)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.2 GO:0002178 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.2 GO:0001740 Barr body(GO:0001740)
0.0 0.3 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.2 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.2 GO:0042598 obsolete vesicular fraction(GO:0042598)
0.0 0.2 GO:0005915 zonula adherens(GO:0005915)
0.0 0.4 GO:0019861 obsolete flagellum(GO:0019861)
0.0 0.1 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.1 GO:0042827 platelet dense granule(GO:0042827)
0.0 0.0 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.0 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.0 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.0 GO:0071001 U4/U6 snRNP(GO:0071001)
0.0 0.0 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 0.0 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.0 GO:0005641 nuclear envelope lumen(GO:0005641)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0000247 C-8 sterol isomerase activity(GO:0000247)
0.1 0.2 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 0.2 GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.1 0.2 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 0.2 GO:0034452 dynactin binding(GO:0034452)
0.0 0.2 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.0 0.1 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 0.1 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.2 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0 0.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.1 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.0 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.1 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 0.0 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.1 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.0 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.0 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.2 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.0 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.0 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.0 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.0 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.1 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0 0.4 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.3 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.1 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.0 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.0 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 0.3 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.1 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 0.2 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.3 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.3 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.3 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.2 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.1 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.2 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)