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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for BACH2

Z-value: 1.07

Motif logo

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Transcription factors associated with BACH2

Gene Symbol Gene ID Gene Info
BACH2
ENSG00000112182.10 BTB domain and CNC homolog 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr6_90897115_90897402BACH21092030.0649270.761.9e-02Click!
chr6_90928649_90929126BACH2775740.103711-0.742.3e-02Click!
chr6_91002405_91002556BACH239810.2867900.732.7e-02Click!
chr6_90927892_90928130BACH2784500.102322-0.646.3e-02Click!
chr6_90927639_90927889BACH2786970.101935-0.627.3e-02Click!

Activity of the BACH2 motif across conditions

Conditions sorted by the z-value of the BACH2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr14_105531321_105531563 0.78 GPR132
 G protein-coupled receptor 132
 325
 0.89
chr3_196368340_196368779 0.66 PIGX
 phosphatidylinositol glycan anchor biosynthesis, class X
 1913
 0.22
chr19_2562041_2562223 0.64 CTC-265F19.2
49728
 0.09
chr5_150601304_150601455 0.60 CCDC69
 coiled-coil domain containing 69
 2327
 0.29
chr16_28995938_28996254 0.56 LAT
 linker for activation of T cells
 51
 0.94
chr1_45769094_45769262 0.52 HPDL
 4-hydroxyphenylpyruvate dioxygenase-like
 23367
 0.14
chr7_73508316_73508712 0.50 LIMK1
 LIM domain kinase 1
 1105
 0.51
chr5_130588828_130589214 0.50 CDC42SE2
 CDC42 small effector 2
 10681
 0.28
chr1_248069833_248069987 0.49 OR2W3
 olfactory receptor, family 2, subfamily W, member 3
 11021
 0.1
chr1_160983030_160983181 0.47 F11R
 F11 receptor
 7781
 0.11
chr3_47018515_47018698 0.45 CCDC12
 coiled-coil domain containing 12
 336
 0.86
chr1_160548517_160548751 0.44 CD84
 CD84 molecule
 629
 0.67
chr15_77289158_77289399 0.44 PSTPIP1
 proline-serine-threonine phosphatase interacting protein 1
 1363
 0.44
chr10_6317420_6317571 0.44 ENSG00000238366
 .
 29701
 0.16
chr7_1572516_1572667 0.44 MAFK
 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
 2241
 0.23
chr6_139458021_139458384 0.41 HECA
 headcase homolog (Drosophila)
 1953
 0.43
chr2_231090336_231091061 0.41 SP140
 SP140 nuclear body protein
 219
 0.54
chr2_28810076_28810227 0.41 PLB1
 phospholipase B1
 14635
 0.23
chr5_133801504_133801725 0.40 ENSG00000207222
 .
 34361
 0.12
chr16_48642312_48642839 0.40 N4BP1
 NEDD4 binding protein 1
 1545
 0.4
chr12_6445436_6445689 0.39 TNFRSF1A
 tumor necrosis factor receptor superfamily, member 1A
 5452
 0.13
chr18_74845425_74845585 0.39 MBP
 myelin basic protein
 705
 0.8
chr2_43448437_43448588 0.39 ZFP36L2
 ZFP36 ring finger protein-like 2
 5236
 0.25
chr12_96592768_96592919 0.38 ELK3
 ELK3, ETS-domain protein (SRF accessory protein 2)
 4451
 0.24
chr20_1470626_1470777 0.38 SIRPB2
 signal-regulatory protein beta 2
 1341
 0.29
chr22_46409167_46409603 0.37 WNT7B
 wingless-type MMTV integration site family, member 7B
 36376
 0.09
chr1_31229648_31230364 0.37 LAPTM5
 lysosomal protein transmembrane 5
 661
 0.67
chr1_111422762_111422913 0.37 CD53
 CD53 molecule
 7061
 0.2
chr12_57872273_57872424 0.36 ARHGAP9
 Rho GTPase activating protein 9
 45
 0.94
chr5_74964815_74965486 0.36 ENSG00000207333
 .
 40274
 0.14
chr22_20830100_20830251 0.36 ENSG00000255156
 .
 577
 0.57
chr13_50114703_50115207 0.35 RCBTB1
 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
 26504
 0.17
chr1_26611162_26611428 0.35 SH3BGRL3
 SH3 domain binding glutamic acid-rich protein like 3
 4682
 0.13
chr8_126442398_126442549 0.34 TRIB1
 tribbles pseudokinase 1
 90
 0.98
chr6_43597230_43597731 0.34 MAD2L1BP
 MAD2L1 binding protein
 203
 0.78
chr3_47326086_47326237 0.34 KIF9
 kinesin family member 9
 1220
 0.37
chr17_75439465_75439616 0.34 ENSG00000200651
 .
 1349
 0.37
chr17_75138230_75138411 0.33 SEC14L1
 SEC14-like 1 (S. cerevisiae)
 852
 0.63
chr5_132389617_132389768 0.33 HSPA4
 heat shock 70kDa protein 4
 2038
 0.31
chr10_22919722_22919988 0.33 PIP4K2A
 phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
 39213
 0.21
chr11_9385409_9385962 0.32 IPO7
 importin 7
 20484
 0.16
chr15_52313401_52313552 0.32 MAPK6
 mitogen-activated protein kinase 6
 2078
 0.27
chr20_3725549_3725774 0.31 HSPA12B
 heat shock 70kD protein 12B
 12303
 0.12
chr19_14896102_14896264 0.31 EMR2
 egf-like module containing, mucin-like, hormone receptor-like 2
 6830
 0.15
chr1_226897694_226897845 0.30 ITPKB
 inositol-trisphosphate 3-kinase B
 27390
 0.17
chr2_192053899_192054070 0.30 STAT4
 signal transducer and activator of transcription 4
 37662
 0.16
chr17_74495503_74495654 0.30 RHBDF2
 rhomboid 5 homolog 2 (Drosophila)
 1875
 0.2
chr22_36781766_36782330 0.30 MYH9
 myosin, heavy chain 9, non-muscle
 2015
 0.32
chr1_198610920_198611071 0.30 PTPRC
 protein tyrosine phosphatase, receptor type, C
 2703
 0.34
chr1_244486436_244486726 0.30 C1orf100
 chromosome 1 open reading frame 100
 29356
 0.21
chr1_6086993_6087271 0.30 KCNAB2
 potassium voltage-gated channel, shaker-related subfamily, beta member 2
 225
 0.93
chr19_39894109_39894559 0.29 ZFP36
 ZFP36 ring finger protein
 3119
 0.1
chr19_11449251_11449402 0.29 RAB3D
 RAB3D, member RAS oncogene family
 1018
 0.31
chr11_18405338_18405489 0.29 ENSG00000264603
 .
 3921
 0.14
chr5_67730038_67730311 0.29 PIK3R1
 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
 141778
 0.05
chr12_47605032_47605192 0.29 PCED1B
 PC-esterase domain containing 1B
 4940
 0.24
chrX_71321072_71321371 0.28 RGAG4
 retrotransposon gag domain containing 4
 30457
 0.14
chr19_909296_909447 0.28 R3HDM4
 R3H domain containing 4
 3860
 0.1
chr8_126308914_126309065 0.28 ENSG00000242170
 .
 26143
 0.21
chrX_49023399_49023590 0.28 MAGIX
 MAGI family member, X-linked
 2612
 0.12
chr16_279128_279418 0.28 LUC7L
 LUC7-like (S. cerevisiae)
 148
 0.91
chr14_68717009_68717160 0.28 ENSG00000243546
 .
 13828
 0.27
chr1_6844402_6844649 0.27 RP11-312B8.1
378
 0.72
chr2_99069202_99069353 0.27 INPP4A
 inositol polyphosphate-4-phosphatase, type I, 107kDa
 7864
 0.24
chr7_45069535_45069723 0.27 CCM2
 cerebral cavernous malformation 2
 2358
 0.23
chr8_30513601_30513752 0.27 GTF2E2
 general transcription factor IIE, polypeptide 2, beta 34kDa
 846
 0.59
chrX_41193502_41193753 0.27 DDX3X
 DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
 212
 0.93
chr15_78374826_78374977 0.27 SH2D7
 SH2 domain containing 7
 4751
 0.14
chr10_73532045_73532374 0.27 C10orf54
 chromosome 10 open reading frame 54
 1046
 0.53
chrX_70402024_70402577 0.26 RP5-1091N2.9
15725
 0.12
chr19_3178230_3178381 0.26 S1PR4
 sphingosine-1-phosphate receptor 4
 431
 0.74
chr22_27054974_27055244 0.26 CRYBA4
 crystallin, beta A4
 37181
 0.15
chr10_45870440_45870591 0.26 ALOX5
 arachidonate 5-lipoxygenase
 840
 0.69
chr2_99131735_99131886 0.26 INPP4A
 inositol polyphosphate-4-phosphatase, type I, 107kDa
 4702
 0.28
chr1_154378708_154379562 0.26 RP11-350G8.5
95
 0.93
chr12_14924776_14925101 0.26 HIST4H4
 histone cluster 4, H4
 873
 0.43
chrY_15016828_15017148 0.25 DDX3Y
 DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
 246
 0.96
chr9_36141464_36141615 0.25 GLIPR2
 GLI pathogenesis-related 2
 4797
 0.21
chr14_75085047_75085411 0.25 LTBP2
 latent transforming growth factor beta binding protein 2
 5923
 0.21
chr13_41884953_41885353 0.25 NAA16
 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
 188
 0.95
chr3_5055062_5055354 0.25 BHLHE40-AS1
 BHLHE40 antisense RNA 1
 33562
 0.15
chr8_67592155_67592325 0.25 C8orf44
 chromosome 8 open reading frame 44
 3786
 0.17
chr17_56410108_56410593 0.25 MIR142
 microRNA 142
 481
 0.66
chr19_48246517_48246668 0.24 GLTSCR2
 glioma tumor suppressor candidate region gene 2
 2187
 0.21
chr17_20601796_20602095 0.24 AC126365.1
17851
 0.23
chr19_2089959_2090185 0.24 MOB3A
 MOB kinase activator 3A
 103
 0.94
chr1_95261518_95261669 0.24 SLC44A3
 solute carrier family 44, member 3
 24305
 0.19
chr18_3595540_3596159 0.24 DLGAP1-AS1
 DLGAP1 antisense RNA 1
 1396
 0.36
chr1_40157482_40157633 0.24 HPCAL4
 hippocalcin like 4
 196
 0.61
chr1_36852243_36852394 0.24 STK40
 serine/threonine kinase 40
 821
 0.5
chr12_1434091_1434389 0.24 RP5-951N9.2
60759
 0.12
chr7_5595689_5595960 0.24 CTB-161C1.1
538
 0.69
chr2_122288534_122288940 0.24 ENSG00000264229
 .
 280
 0.79
chr10_45870253_45870404 0.23 ALOX5
 arachidonate 5-lipoxygenase
 653
 0.77
chr11_47787507_47787658 0.23 FNBP4
 formin binding protein 4
 1271
 0.36
chr13_75900551_75900966 0.23 TBC1D4
 TBC1 domain family, member 4
 14909
 0.24
chrX_153941197_153941348 0.23 GAB3
 GRB2-associated binding protein 3
 32776
 0.1
chr22_32871360_32872181 0.23 FBXO7
 F-box protein 7
 190
 0.94
chr11_118754601_118754752 0.23 CXCR5
 chemokine (C-X-C motif) receptor 5
 201
 0.88
chr14_103801113_103802028 0.23 EIF5
 eukaryotic translation initiation factor 5
 284
 0.87
chr2_47649361_47649512 0.23 MSH2
 mutS homolog 2
 19167
 0.17
chr3_50354430_50354581 0.23 HYAL2
 hyaluronoglucosaminidase 2
 3874
 0.08
chr2_114008714_114008865 0.23 ENSG00000189223
 .
 446
 0.78
chr19_47853304_47853535 0.23 DHX34
 DEAH (Asp-Glu-Ala-His) box polypeptide 34
 881
 0.52
chr19_14494809_14495344 0.23 CD97
 CD97 molecule
 2820
 0.2
chr1_223738388_223738539 0.23 CAPN8
 calpain 8
 14083
 0.27
chr13_34116508_34116659 0.23 STARD13
 StAR-related lipid transfer (START) domain containing 13
 191816
 0.03
chr8_145022714_145022952 0.23 PLEC
 plectin
 2118
 0.18
chr20_57721681_57721954 0.23 ZNF831
 zinc finger protein 831
 44258
 0.15
chr12_53616534_53616822 0.23 RARG
 retinoic acid receptor, gamma
 2481
 0.17
chr15_89952076_89952330 0.23 ENSG00000207819
 .
 40955
 0.13
chr12_15104110_15104261 0.22 ARHGDIB
 Rho GDP dissociation inhibitor (GDI) beta
 100
 0.96
chr17_44257050_44257201 0.22 KANSL1
 KAT8 regulatory NSL complex subunit 1
 7531
 0.17
chr3_32995983_32996275 0.22 CCR4
 chemokine (C-C motif) receptor 4
 3063
 0.34
chr12_109022383_109022629 0.22 RP11-689B22.2
43
 0.96
chr18_43754040_43754305 0.22 C18orf25
 chromosome 18 open reading frame 25
 172
 0.96
chr14_104094277_104094428 0.22 KLC1
 kinesin light chain 1
 1162
 0.33
chr4_38762729_38763007 0.22 ENSG00000222230
 .
 2355
 0.26
chr9_130717791_130717942 0.22 FAM102A
 family with sequence similarity 102, member A
 4865
 0.11
chr17_78865183_78865610 0.22 RPTOR
 regulatory associated protein of MTOR, complex 1
 31128
 0.13
chr1_158789498_158789649 0.22 MNDA
 myeloid cell nuclear differentiation antigen
 11534
 0.17
chr1_45196821_45197082 0.21 ENSG00000200169
 .
 109
 0.92
chr1_28640614_28640765 0.21 MED18
 mediator complex subunit 18
 14860
 0.15
chr3_190304394_190304671 0.21 IL1RAP
 interleukin 1 receptor accessory protein
 23297
 0.23
chr16_67571099_67571332 0.21 FAM65A
 family with sequence similarity 65, member A
 142
 0.9
chr9_132595482_132595633 0.21 C9orf78
 chromosome 9 open reading frame 78
 1997
 0.23
chr15_89630929_89631312 0.21 RP11-326A19.3
52
 0.77
chr5_177540474_177540824 0.21 N4BP3
 NEDD4 binding protein 3
 205
 0.93
chr20_33680803_33681037 0.21 TRPC4AP
 transient receptor potential cation channel, subfamily C, member 4 associated protein
 246
 0.9
chr5_169705883_169706422 0.21 LCP2
 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
 11821
 0.22
chr9_117134390_117135168 0.20 AKNA
 AT-hook transcription factor
 4465
 0.23
chr6_35568962_35570321 0.20 ENSG00000212579
 .
 49954
 0.1
chr5_10632325_10632658 0.20 ANKRD33B-AS1
 ANKRD33B antisense RNA 1
 4154
 0.28
chr1_8000859_8001010 0.20 TNFRSF9
 tumor necrosis factor receptor superfamily, member 9
 8
 0.98
chr5_167229311_167229462 0.20 TENM2
 teneurin transmembrane protein 2
 47378
 0.15
chr12_120669177_120669328 0.20 PXN
 paxillin
 4605
 0.14
chr13_108919519_108919670 0.20 TNFSF13B
 tumor necrosis factor (ligand) superfamily, member 13b
 2383
 0.32
chr1_172628190_172628341 0.20 FASLG
 Fas ligand (TNF superfamily, member 6)
 107
 0.98
chr2_64870286_64870742 0.20 SERTAD2
 SERTA domain containing 2
 10533
 0.23
chr19_51920344_51920879 0.20 SIGLEC10
 sialic acid binding Ig-like lectin 10
 224
 0.81
chr14_94425760_94425911 0.20 ASB2
 ankyrin repeat and SOCS box containing 2
 2068
 0.26
chr3_101655473_101655624 0.20 ENSG00000202177
 .
 18373
 0.23
chr22_43288275_43288426 0.20 ARFGAP3
 ADP-ribosylation factor GTPase activating protein 3
 34238
 0.17
chr18_9404902_9405053 0.20 RALBP1
 ralA binding protein 1
 70030
 0.08
chr17_45814129_45814344 0.20 TBX21
 T-box 21
 3626
 0.18
chr17_34409877_34410116 0.20 AC069363.1
1004
 0.35
chr19_13957589_13958095 0.19 ENSG00000207980
 .
 10369
 0.08
chr2_99082787_99082938 0.19 INPP4A
 inositol polyphosphate-4-phosphatase, type I, 107kDa
 21449
 0.22
chr20_45983820_45984266 0.19 ZMYND8
 zinc finger, MYND-type containing 8
 358
 0.81
chr1_954607_954781 0.19 AGRN
 agrin
 809
 0.4
chr16_31276706_31276857 0.19 ENSG00000252876
 .
 2031
 0.19
chr2_118943251_118943914 0.19 INSIG2
 insulin induced gene 2
 97532
 0.08
chr1_109791733_109792083 0.19 CELSR2
 cadherin, EGF LAG seven-pass G-type receptor 2
 733
 0.6
chr10_11726764_11728101 0.19 ECHDC3
 enoyl CoA hydratase domain containing 3
 56933
 0.13
chr16_25060015_25060182 0.19 ARHGAP17
 Rho GTPase activating protein 17
 33111
 0.18
chr16_6522320_6522471 0.19 RBFOX1
 RNA binding protein, fox-1 homolog (C. elegans) 1
 10785
 0.3
chr3_72226253_72226548 0.19 ENSG00000212070
 .
 85179
 0.1
chr3_186993064_186993215 0.19 MASP1
 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
 16346
 0.21
chr6_34283894_34284092 0.19 C6orf1
 chromosome 6 open reading frame 1
 66746
 0.09
chr1_10570811_10571317 0.19 PEX14
 peroxisomal biogenesis factor 14
 36025
 0.11
chr19_39321682_39322469 0.19 ECH1
 enoyl CoA hydratase 1, peroxisomal
 224
 0.82
chr4_8230456_8230607 0.19 SH3TC1
 SH3 domain and tetratricopeptide repeats 1
 12040
 0.22
chr10_102758058_102758214 0.19 LZTS2
 leucine zipper, putative tumor suppressor 2
 31
 0.95
chr4_14198140_14198291 0.18 ENSG00000202449
 .
 494119
 0.0
chr20_62368732_62368892 0.18 LIME1
 Lck interacting transmembrane adaptor 1
 175
 0.82
chr8_54571850_54572001 0.18 ATP6V1H
 ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
 180596
 0.03
chr15_61013207_61013362 0.18 ENSG00000212625
 .
 15684
 0.2
chr8_59466247_59466777 0.18 SDCBP
 syndecan binding protein (syntenin)
 698
 0.76
chr1_2266428_2266579 0.18 AL589739.1
 Uncharacterized protein
 7922
 0.11
chr6_135408926_135409077 0.18 HBS1L
 HBS1-like (S. cerevisiae)
 15193
 0.21
chr12_120690170_120690321 0.18 PXN
 paxillin
 2281
 0.2
chr20_30160458_30160983 0.18 HM13-AS1
 HM13 antisense RNA 1
 346
 0.8
chr11_123985768_123986166 0.18 VWA5A
 von Willebrand factor A domain containing 5A
 102
 0.97
chr18_9825591_9825815 0.18 ENSG00000242651
 .
 4921
 0.21
chr3_30653355_30653657 0.18 TGFBR2
 transforming growth factor, beta receptor II (70/80kDa)
 5413
 0.33
chr17_79651117_79651428 0.18 HGS
 hepatocyte growth factor-regulated tyrosine kinase substrate
 134
 0.69
chr17_61904834_61905197 0.18 FTSJ3
 FtsJ homolog 3 (E. coli)
 8
 0.53
chr20_61455814_61456027 0.18 COL9A3
 collagen, type IX, alpha 3
 6757
 0.12
chrX_13665897_13666048 0.18 TCEANC
 transcription elongation factor A (SII) N-terminal and central domain containing
 5253
 0.22
chr17_1552617_1553136 0.18 RILP
 Rab interacting lysosomal protein
 495
 0.61
chr11_33912969_33913137 0.18 LMO2
 LIM domain only 2 (rhombotin-like 1)
 783
 0.67
chr1_235668084_235668715 0.18 B3GALNT2
 beta-1,3-N-acetylgalactosaminyltransferase 2
 618
 0.8
chrX_56820275_56820426 0.18 ENSG00000204272
 .
 64658
 0.14
chr16_30077190_30078018 0.18 ALDOA
 aldolase A, fructose-bisphosphate
 96
 0.92
chr18_2658233_2658442 0.18 SMCHD1
 structural maintenance of chromosomes flexible hinge domain containing 1
 2451
 0.24
chr9_130681751_130681902 0.18 ST6GALNAC4
 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
 2521
 0.13
chr4_40201423_40201705 0.18 RHOH
 ras homolog family member H
 400
 0.87
chr22_37625645_37625816 0.18 RAC2
 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
 14558
 0.13
chr5_140090759_140091080 0.18 ENSG00000199990
 .
 59
 0.93
chr10_6019287_6019858 0.17 IL15RA
 interleukin 15 receptor, alpha
 2
 0.97
chr10_8095504_8096368 0.17 GATA3
 GATA binding protein 3
 720
 0.81
chr11_104914891_104915295 0.17 CARD16
 caspase recruitment domain family, member 16
 941
 0.54
chr5_42950238_42951303 0.17 SEPP1
 selenoprotein P, plasma, 1
 63276
 0.1
chr20_44439937_44440088 0.17 UBE2C
 ubiquitin-conjugating enzyme E2C
 1203
 0.27
chr3_37033296_37034262 0.17 EPM2AIP1
 EPM2A (laforin) interacting protein 1
 1016
 0.36
chr1_202777207_202777594 0.17 KDM5B
 lysine (K)-specific demethylase 5B
 146
 0.92
chr8_125384746_125384961 0.17 TMEM65
 transmembrane protein 65
 80
 0.98
chrX_19816618_19816769 0.17 SH3KBP1
 SH3-domain kinase binding protein 1
 1176
 0.63
chr13_28000222_28001106 0.17 GTF3A
 general transcription factor IIIA
 1983
 0.29
chr17_80817564_80818630 0.17 TBCD
 tubulin folding cofactor D
 173
 0.94

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of BACH2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.1 0.4 GO:0019372 lipoxygenase pathway(GO:0019372)
0.1 0.2 GO:0048388 endosomal lumen acidification(GO:0048388)
0.1 0.3 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1 0.2 GO:0043578 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1 0.1 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.1 0.2 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 0.1 GO:0045341 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0 0.1 GO:0070669 response to interleukin-2(GO:0070669)
0.0 0.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.1 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.0 0.1 GO:0000042 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0 0.1 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.0 0.6 GO:0043303 mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.0 0.1 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
0.0 0.1 GO:0046021 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0 0.2 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 0.1 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.0 0.3 GO:0051322 anaphase(GO:0051322)
0.0 0.1 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.2 GO:0045576 mast cell activation(GO:0045576)
0.0 0.0 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.3 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 0.1 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.0 0.2 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.1 GO:0033632 regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0 0.1 GO:0045040 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.1 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.0 0.1 GO:0051775 response to redox state(GO:0051775)
0.0 0.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.2 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.1 GO:0051532 NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0 0.1 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.1 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.1 GO:0021999 neural plate anterior/posterior regionalization(GO:0021999) neural plate regionalization(GO:0060897)
0.0 0.1 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.1 GO:0045007 depurination(GO:0045007)
0.0 0.1 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.2 GO:0048535 lymph node development(GO:0048535)
0.0 0.3 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.0 0.1 GO:0048712 negative regulation of astrocyte differentiation(GO:0048712)
0.0 0.0 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0 0.1 GO:0097094 cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0 0.0 GO:0002887 negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.0 0.1 GO:0001866 NK T cell proliferation(GO:0001866)
0.0 0.0 GO:0002323 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0 0.1 GO:0034243 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968) regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)
0.0 0.3 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.0 0.1 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0 0.0 GO:0002866 positive regulation of inflammatory response to antigenic stimulus(GO:0002863) positive regulation of acute inflammatory response to antigenic stimulus(GO:0002866) positive regulation of hypersensitivity(GO:0002885)
0.0 0.1 GO:0022030 cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0 0.0 GO:0051461 corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0 0.0 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.0 0.0 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.0 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 0.0 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.0 0.1 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.0 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.1 GO:0000019 regulation of mitotic recombination(GO:0000019)
0.0 0.0 GO:0045990 carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015)
0.0 0.0 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.0 0.0 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0 0.0 GO:0046599 regulation of centriole replication(GO:0046599)
0.0 0.1 GO:0042159 lipoprotein catabolic process(GO:0042159)
0.0 0.1 GO:0032988 ribonucleoprotein complex disassembly(GO:0032988)
0.0 0.0 GO:0045759 negative regulation of action potential(GO:0045759)
0.0 0.1 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.1 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.1 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.1 GO:0032875 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0 0.1 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.1 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.0 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.0 0.0 GO:0044415 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.0 GO:0060896 neural plate pattern specification(GO:0060896)
0.0 0.0 GO:0015864 pyrimidine nucleoside transport(GO:0015864)
0.0 0.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.0 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.3 GO:0016236 macroautophagy(GO:0016236)
0.0 0.1 GO:0002507 tolerance induction(GO:0002507)
0.0 0.1 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.0 0.0 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.2 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.0 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.0 0.0 GO:0006007 glucose catabolic process(GO:0006007)
0.0 0.0 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.1 GO:1903672 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.0 0.1 GO:0030224 monocyte differentiation(GO:0030224)
0.0 0.0 GO:0045410 positive regulation of interleukin-6 biosynthetic process(GO:0045410)
0.0 0.1 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.0 GO:0060433 bronchus development(GO:0060433)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 0.4 GO:0043218 compact myelin(GO:0043218)
0.1 0.3 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 0.2 GO:0070062 extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0 0.2 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.6 GO:0001772 immunological synapse(GO:0001772)
0.0 0.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.2 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 0.2 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.1 GO:0005827 polar microtubule(GO:0005827)
0.0 0.1 GO:0070188 obsolete Stn1-Ten1 complex(GO:0070188)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.2 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.4 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.1 GO:0045179 apical cortex(GO:0045179)
0.0 0.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.1 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.1 GO:0002102 podosome(GO:0002102)
0.0 0.1 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.0 0.1 GO:0042555 MCM complex(GO:0042555)
0.0 0.0 GO:0033150 cytoskeletal calyx(GO:0033150)
0.0 0.0 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.0 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.0 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.0 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.0 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.1 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.3 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.1 0.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.4 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165)
0.1 0.2 GO:0034648 histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0 0.3 GO:0005521 lamin binding(GO:0005521)
0.0 0.2 GO:0050733 RS domain binding(GO:0050733)
0.0 0.1 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.1 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.2 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.1 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.1 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.1 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.1 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.1 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.1 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.1 GO:0032407 MutSalpha complex binding(GO:0032407)
0.0 0.1 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.1 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.0 0.1 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.1 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.1 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.0 0.2 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0 0.1 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.1 GO:0051400 BH domain binding(GO:0051400)
0.0 0.1 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.1 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.0 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.0 0.3 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.0 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.1 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.1 GO:0019864 IgG binding(GO:0019864)
0.0 0.0 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.0 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.3 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.1 GO:0001012 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 0.0 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.0 GO:0097493 extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0 0.0 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0 0.1 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.2 GO:0043022 ribosome binding(GO:0043022)
0.0 0.1 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.1 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.0 GO:0034452 dynactin binding(GO:0034452)
0.0 0.2 GO:0070888 E-box binding(GO:0070888)
0.0 0.1 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 0.4 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.0 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.1 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.1 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.1 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.0 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0 0.1 GO:0003709 obsolete RNA polymerase III transcription factor activity(GO:0003709)
0.0 0.0 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.0 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.0 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.0 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0005095 GTPase inhibitor activity(GO:0005095)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.6 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.3 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.3 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.1 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.3 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.7 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.4 PID TNF PATHWAY TNF receptor signaling pathway
0.0 0.6 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.3 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.7 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.3 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.1 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.3 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.1 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.1 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.1 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.0 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.0 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.3 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.3 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.2 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)