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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for BACH2

Z-value: 1.07

Motif logo

Transcription factors associated with BACH2

Gene Symbol	Gene ID	Gene Info
BACH2 Ensembl NCBI GeneCards UniProt	ENSG00000112182.10	BACH2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
BACH2	chr6_90897115_90897402	109203	0.064927	0.76	1.9e-02	Click!
BACH2	chr6_90928649_90929126	77574	0.103711	-0.74	2.3e-02	Click!
BACH2	chr6_91002405_91002556	3981	0.286790	0.73	2.7e-02	Click!
BACH2	chr6_90927892_90928130	78450	0.102322	-0.64	6.3e-02	Click!
BACH2	chr6_90927639_90927889	78697	0.101935	-0.62	7.3e-02	Click!

Activity of the BACH2 motif across conditions

Conditions sorted by the z-value of the BACH2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr14_105531321_105531563	0.78	GPR132	G protein-coupled receptor 132	325	0.89
chr3_196368340_196368779	0.66	PIGX	phosphatidylinositol glycan anchor biosynthesis, class X	1913	0.22
chr19_2562041_2562223	0.64	CTC-265F19.2		49728	0.09
chr5_150601304_150601455	0.60	CCDC69	coiled-coil domain containing 69	2327	0.29
chr16_28995938_28996254	0.56	LAT	linker for activation of T cells	51	0.94
chr1_45769094_45769262	0.52	HPDL	4-hydroxyphenylpyruvate dioxygenase-like	23367	0.14
chr7_73508316_73508712	0.50	LIMK1	LIM domain kinase 1	1105	0.51
chr5_130588828_130589214	0.50	CDC42SE2	CDC42 small effector 2	10681	0.28
chr1_248069833_248069987	0.49	OR2W3	olfactory receptor, family 2, subfamily W, member 3	11021	0.1
chr1_160983030_160983181	0.47	F11R	F11 receptor	7781	0.11
chr3_47018515_47018698	0.45	CCDC12	coiled-coil domain containing 12	336	0.86
chr1_160548517_160548751	0.44	CD84	CD84 molecule	629	0.67
chr15_77289158_77289399	0.44	PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	1363	0.44
chr10_6317420_6317571	0.44	ENSG00000238366	.	29701	0.16
chr7_1572516_1572667	0.44	MAFK	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K	2241	0.23
chr6_139458021_139458384	0.41	HECA	headcase homolog (Drosophila)	1953	0.43
chr2_231090336_231091061	0.41	SP140	SP140 nuclear body protein	219	0.54
chr2_28810076_28810227	0.41	PLB1	phospholipase B1	14635	0.23
chr5_133801504_133801725	0.40	ENSG00000207222	.	34361	0.12
chr16_48642312_48642839	0.40	N4BP1	NEDD4 binding protein 1	1545	0.4
chr12_6445436_6445689	0.39	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	5452	0.13
chr18_74845425_74845585	0.39	MBP	myelin basic protein	705	0.8
chr2_43448437_43448588	0.39	ZFP36L2	ZFP36 ring finger protein-like 2	5236	0.25
chr12_96592768_96592919	0.38	ELK3	ELK3, ETS-domain protein (SRF accessory protein 2)	4451	0.24
chr20_1470626_1470777	0.38	SIRPB2	signal-regulatory protein beta 2	1341	0.29
chr22_46409167_46409603	0.37	WNT7B	wingless-type MMTV integration site family, member 7B	36376	0.09
chr1_31229648_31230364	0.37	LAPTM5	lysosomal protein transmembrane 5	661	0.67
chr1_111422762_111422913	0.37	CD53	CD53 molecule	7061	0.2
chr12_57872273_57872424	0.36	ARHGAP9	Rho GTPase activating protein 9	45	0.94
chr5_74964815_74965486	0.36	ENSG00000207333	.	40274	0.14
chr22_20830100_20830251	0.36	ENSG00000255156	.	577	0.57
chr13_50114703_50115207	0.35	RCBTB1	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1	26504	0.17
chr1_26611162_26611428	0.35	SH3BGRL3	SH3 domain binding glutamic acid-rich protein like 3	4682	0.13
chr8_126442398_126442549	0.34	TRIB1	tribbles pseudokinase 1	90	0.98
chr6_43597230_43597731	0.34	MAD2L1BP	MAD2L1 binding protein	203	0.78
chr3_47326086_47326237	0.34	KIF9	kinesin family member 9	1220	0.37
chr17_75439465_75439616	0.34	ENSG00000200651	.	1349	0.37
chr17_75138230_75138411	0.33	SEC14L1	SEC14-like 1 (S. cerevisiae)	852	0.63
chr5_132389617_132389768	0.33	HSPA4	heat shock 70kDa protein 4	2038	0.31
chr10_22919722_22919988	0.33	PIP4K2A	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	39213	0.21
chr11_9385409_9385962	0.32	IPO7	importin 7	20484	0.16
chr15_52313401_52313552	0.32	MAPK6	mitogen-activated protein kinase 6	2078	0.27
chr20_3725549_3725774	0.31	HSPA12B	heat shock 70kD protein 12B	12303	0.12
chr19_14896102_14896264	0.31	EMR2	egf-like module containing, mucin-like, hormone receptor-like 2	6830	0.15
chr1_226897694_226897845	0.30	ITPKB	inositol-trisphosphate 3-kinase B	27390	0.17
chr2_192053899_192054070	0.30	STAT4	signal transducer and activator of transcription 4	37662	0.16
chr17_74495503_74495654	0.30	RHBDF2	rhomboid 5 homolog 2 (Drosophila)	1875	0.2
chr22_36781766_36782330	0.30	MYH9	myosin, heavy chain 9, non-muscle	2015	0.32
chr1_198610920_198611071	0.30	PTPRC	protein tyrosine phosphatase, receptor type, C	2703	0.34
chr1_244486436_244486726	0.30	C1orf100	chromosome 1 open reading frame 100	29356	0.21
chr1_6086993_6087271	0.30	KCNAB2	potassium voltage-gated channel, shaker-related subfamily, beta member 2	225	0.93
chr19_39894109_39894559	0.29	ZFP36	ZFP36 ring finger protein	3119	0.1
chr19_11449251_11449402	0.29	RAB3D	RAB3D, member RAS oncogene family	1018	0.31
chr11_18405338_18405489	0.29	ENSG00000264603	.	3921	0.14
chr5_67730038_67730311	0.29	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	141778	0.05
chr12_47605032_47605192	0.29	PCED1B	PC-esterase domain containing 1B	4940	0.24
chrX_71321072_71321371	0.28	RGAG4	retrotransposon gag domain containing 4	30457	0.14
chr19_909296_909447	0.28	R3HDM4	R3H domain containing 4	3860	0.1
chr8_126308914_126309065	0.28	ENSG00000242170	.	26143	0.21
chrX_49023399_49023590	0.28	MAGIX	MAGI family member, X-linked	2612	0.12
chr16_279128_279418	0.28	LUC7L	LUC7-like (S. cerevisiae)	148	0.91
chr14_68717009_68717160	0.28	ENSG00000243546	.	13828	0.27
chr1_6844402_6844649	0.27	RP11-312B8.1		378	0.72
chr2_99069202_99069353	0.27	INPP4A	inositol polyphosphate-4-phosphatase, type I, 107kDa	7864	0.24
chr7_45069535_45069723	0.27	CCM2	cerebral cavernous malformation 2	2358	0.23
chr8_30513601_30513752	0.27	GTF2E2	general transcription factor IIE, polypeptide 2, beta 34kDa	846	0.59
chrX_41193502_41193753	0.27	DDX3X	DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked	212	0.93
chr15_78374826_78374977	0.27	SH2D7	SH2 domain containing 7	4751	0.14
chr10_73532045_73532374	0.27	C10orf54	chromosome 10 open reading frame 54	1046	0.53
chrX_70402024_70402577	0.26	RP5-1091N2.9		15725	0.12
chr19_3178230_3178381	0.26	S1PR4	sphingosine-1-phosphate receptor 4	431	0.74
chr22_27054974_27055244	0.26	CRYBA4	crystallin, beta A4	37181	0.15
chr10_45870440_45870591	0.26	ALOX5	arachidonate 5-lipoxygenase	840	0.69
chr2_99131735_99131886	0.26	INPP4A	inositol polyphosphate-4-phosphatase, type I, 107kDa	4702	0.28
chr1_154378708_154379562	0.26	RP11-350G8.5		95	0.93
chr12_14924776_14925101	0.26	HIST4H4	histone cluster 4, H4	873	0.43
chrY_15016828_15017148	0.25	DDX3Y	DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked	246	0.96
chr9_36141464_36141615	0.25	GLIPR2	GLI pathogenesis-related 2	4797	0.21
chr14_75085047_75085411	0.25	LTBP2	latent transforming growth factor beta binding protein 2	5923	0.21
chr13_41884953_41885353	0.25	NAA16	N(alpha)-acetyltransferase 16, NatA auxiliary subunit	188	0.95
chr3_5055062_5055354	0.25	BHLHE40-AS1	BHLHE40 antisense RNA 1	33562	0.15
chr8_67592155_67592325	0.25	C8orf44	chromosome 8 open reading frame 44	3786	0.17
chr17_56410108_56410593	0.25	MIR142	microRNA 142	481	0.66
chr19_48246517_48246668	0.24	GLTSCR2	glioma tumor suppressor candidate region gene 2	2187	0.21
chr17_20601796_20602095	0.24	AC126365.1		17851	0.23
chr19_2089959_2090185	0.24	MOB3A	MOB kinase activator 3A	103	0.94
chr1_95261518_95261669	0.24	SLC44A3	solute carrier family 44, member 3	24305	0.19
chr18_3595540_3596159	0.24	DLGAP1-AS1	DLGAP1 antisense RNA 1	1396	0.36
chr1_40157482_40157633	0.24	HPCAL4	hippocalcin like 4	196	0.61
chr1_36852243_36852394	0.24	STK40	serine/threonine kinase 40	821	0.5
chr12_1434091_1434389	0.24	RP5-951N9.2		60759	0.12
chr7_5595689_5595960	0.24	CTB-161C1.1		538	0.69
chr2_122288534_122288940	0.24	ENSG00000264229	.	280	0.79
chr10_45870253_45870404	0.23	ALOX5	arachidonate 5-lipoxygenase	653	0.77
chr11_47787507_47787658	0.23	FNBP4	formin binding protein 4	1271	0.36
chr13_75900551_75900966	0.23	TBC1D4	TBC1 domain family, member 4	14909	0.24
chrX_153941197_153941348	0.23	GAB3	GRB2-associated binding protein 3	32776	0.1
chr22_32871360_32872181	0.23	FBXO7	F-box protein 7	190	0.94
chr11_118754601_118754752	0.23	CXCR5	chemokine (C-X-C motif) receptor 5	201	0.88
chr14_103801113_103802028	0.23	EIF5	eukaryotic translation initiation factor 5	284	0.87
chr2_47649361_47649512	0.23	MSH2	mutS homolog 2	19167	0.17
chr3_50354430_50354581	0.23	HYAL2	hyaluronoglucosaminidase 2	3874	0.08
chr2_114008714_114008865	0.23	ENSG00000189223	.	446	0.78
chr19_47853304_47853535	0.23	DHX34	DEAH (Asp-Glu-Ala-His) box polypeptide 34	881	0.52
chr19_14494809_14495344	0.23	CD97	CD97 molecule	2820	0.2
chr1_223738388_223738539	0.23	CAPN8	calpain 8	14083	0.27
chr13_34116508_34116659	0.23	STARD13	StAR-related lipid transfer (START) domain containing 13	191816	0.03
chr8_145022714_145022952	0.23	PLEC	plectin	2118	0.18
chr20_57721681_57721954	0.23	ZNF831	zinc finger protein 831	44258	0.15
chr12_53616534_53616822	0.23	RARG	retinoic acid receptor, gamma	2481	0.17
chr15_89952076_89952330	0.23	ENSG00000207819	.	40955	0.13
chr12_15104110_15104261	0.22	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	100	0.96
chr17_44257050_44257201	0.22	KANSL1	KAT8 regulatory NSL complex subunit 1	7531	0.17
chr3_32995983_32996275	0.22	CCR4	chemokine (C-C motif) receptor 4	3063	0.34
chr12_109022383_109022629	0.22	RP11-689B22.2		43	0.96
chr18_43754040_43754305	0.22	C18orf25	chromosome 18 open reading frame 25	172	0.96
chr14_104094277_104094428	0.22	KLC1	kinesin light chain 1	1162	0.33
chr4_38762729_38763007	0.22	ENSG00000222230	.	2355	0.26
chr9_130717791_130717942	0.22	FAM102A	family with sequence similarity 102, member A	4865	0.11
chr17_78865183_78865610	0.22	RPTOR	regulatory associated protein of MTOR, complex 1	31128	0.13
chr1_158789498_158789649	0.22	MNDA	myeloid cell nuclear differentiation antigen	11534	0.17
chr1_45196821_45197082	0.21	ENSG00000200169	.	109	0.92
chr1_28640614_28640765	0.21	MED18	mediator complex subunit 18	14860	0.15
chr3_190304394_190304671	0.21	IL1RAP	interleukin 1 receptor accessory protein	23297	0.23
chr16_67571099_67571332	0.21	FAM65A	family with sequence similarity 65, member A	142	0.9
chr9_132595482_132595633	0.21	C9orf78	chromosome 9 open reading frame 78	1997	0.23
chr15_89630929_89631312	0.21	RP11-326A19.3		52	0.77
chr5_177540474_177540824	0.21	N4BP3	NEDD4 binding protein 3	205	0.93
chr20_33680803_33681037	0.21	TRPC4AP	transient receptor potential cation channel, subfamily C, member 4 associated protein	246	0.9
chr5_169705883_169706422	0.21	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	11821	0.22
chr9_117134390_117135168	0.20	AKNA	AT-hook transcription factor	4465	0.23
chr6_35568962_35570321	0.20	ENSG00000212579	.	49954	0.1
chr5_10632325_10632658	0.20	ANKRD33B-AS1	ANKRD33B antisense RNA 1	4154	0.28
chr1_8000859_8001010	0.20	TNFRSF9	tumor necrosis factor receptor superfamily, member 9	8	0.98
chr5_167229311_167229462	0.20	TENM2	teneurin transmembrane protein 2	47378	0.15
chr12_120669177_120669328	0.20	PXN	paxillin	4605	0.14
chr13_108919519_108919670	0.20	TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b	2383	0.32
chr1_172628190_172628341	0.20	FASLG	Fas ligand (TNF superfamily, member 6)	107	0.98
chr2_64870286_64870742	0.20	SERTAD2	SERTA domain containing 2	10533	0.23
chr19_51920344_51920879	0.20	SIGLEC10	sialic acid binding Ig-like lectin 10	224	0.81
chr14_94425760_94425911	0.20	ASB2	ankyrin repeat and SOCS box containing 2	2068	0.26
chr3_101655473_101655624	0.20	ENSG00000202177	.	18373	0.23
chr22_43288275_43288426	0.20	ARFGAP3	ADP-ribosylation factor GTPase activating protein 3	34238	0.17
chr18_9404902_9405053	0.20	RALBP1	ralA binding protein 1	70030	0.08
chr17_45814129_45814344	0.20	TBX21	T-box 21	3626	0.18
chr17_34409877_34410116	0.20	AC069363.1		1004	0.35
chr19_13957589_13958095	0.19	ENSG00000207980	.	10369	0.08
chr2_99082787_99082938	0.19	INPP4A	inositol polyphosphate-4-phosphatase, type I, 107kDa	21449	0.22
chr20_45983820_45984266	0.19	ZMYND8	zinc finger, MYND-type containing 8	358	0.81
chr1_954607_954781	0.19	AGRN	agrin	809	0.4
chr16_31276706_31276857	0.19	ENSG00000252876	.	2031	0.19
chr2_118943251_118943914	0.19	INSIG2	insulin induced gene 2	97532	0.08
chr1_109791733_109792083	0.19	CELSR2	cadherin, EGF LAG seven-pass G-type receptor 2	733	0.6
chr10_11726764_11728101	0.19	ECHDC3	enoyl CoA hydratase domain containing 3	56933	0.13
chr16_25060015_25060182	0.19	ARHGAP17	Rho GTPase activating protein 17	33111	0.18
chr16_6522320_6522471	0.19	RBFOX1	RNA binding protein, fox-1 homolog (C. elegans) 1	10785	0.3
chr3_72226253_72226548	0.19	ENSG00000212070	.	85179	0.1
chr3_186993064_186993215	0.19	MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	16346	0.21
chr6_34283894_34284092	0.19	C6orf1	chromosome 6 open reading frame 1	66746	0.09
chr1_10570811_10571317	0.19	PEX14	peroxisomal biogenesis factor 14	36025	0.11
chr19_39321682_39322469	0.19	ECH1	enoyl CoA hydratase 1, peroxisomal	224	0.82
chr4_8230456_8230607	0.19	SH3TC1	SH3 domain and tetratricopeptide repeats 1	12040	0.22
chr10_102758058_102758214	0.19	LZTS2	leucine zipper, putative tumor suppressor 2	31	0.95
chr4_14198140_14198291	0.18	ENSG00000202449	.	494119	0.0
chr20_62368732_62368892	0.18	LIME1	Lck interacting transmembrane adaptor 1	175	0.82
chr8_54571850_54572001	0.18	ATP6V1H	ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H	180596	0.03
chr15_61013207_61013362	0.18	ENSG00000212625	.	15684	0.2
chr8_59466247_59466777	0.18	SDCBP	syndecan binding protein (syntenin)	698	0.76
chr1_2266428_2266579	0.18	AL589739.1	Uncharacterized protein	7922	0.11
chr6_135408926_135409077	0.18	HBS1L	HBS1-like (S. cerevisiae)	15193	0.21
chr12_120690170_120690321	0.18	PXN	paxillin	2281	0.2
chr20_30160458_30160983	0.18	HM13-AS1	HM13 antisense RNA 1	346	0.8
chr11_123985768_123986166	0.18	VWA5A	von Willebrand factor A domain containing 5A	102	0.97
chr18_9825591_9825815	0.18	ENSG00000242651	.	4921	0.21
chr3_30653355_30653657	0.18	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	5413	0.33
chr17_79651117_79651428	0.18	HGS	hepatocyte growth factor-regulated tyrosine kinase substrate	134	0.69
chr17_61904834_61905197	0.18	FTSJ3	FtsJ homolog 3 (E. coli)	8	0.53
chr20_61455814_61456027	0.18	COL9A3	collagen, type IX, alpha 3	6757	0.12
chrX_13665897_13666048	0.18	TCEANC	transcription elongation factor A (SII) N-terminal and central domain containing	5253	0.22
chr17_1552617_1553136	0.18	RILP	Rab interacting lysosomal protein	495	0.61
chr11_33912969_33913137	0.18	LMO2	LIM domain only 2 (rhombotin-like 1)	783	0.67
chr1_235668084_235668715	0.18	B3GALNT2	beta-1,3-N-acetylgalactosaminyltransferase 2	618	0.8
chrX_56820275_56820426	0.18	ENSG00000204272	.	64658	0.14
chr16_30077190_30078018	0.18	ALDOA	aldolase A, fructose-bisphosphate	96	0.92
chr18_2658233_2658442	0.18	SMCHD1	structural maintenance of chromosomes flexible hinge domain containing 1	2451	0.24
chr9_130681751_130681902	0.18	ST6GALNAC4	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4	2521	0.13
chr4_40201423_40201705	0.18	RHOH	ras homolog family member H	400	0.87
chr22_37625645_37625816	0.18	RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	14558	0.13
chr5_140090759_140091080	0.18	ENSG00000199990	.	59	0.93
chr10_6019287_6019858	0.17	IL15RA	interleukin 15 receptor, alpha	2	0.97
chr10_8095504_8096368	0.17	GATA3	GATA binding protein 3	720	0.81
chr11_104914891_104915295	0.17	CARD16	caspase recruitment domain family, member 16	941	0.54
chr5_42950238_42951303	0.17	SEPP1	selenoprotein P, plasma, 1	63276	0.1
chr20_44439937_44440088	0.17	UBE2C	ubiquitin-conjugating enzyme E2C	1203	0.27
chr3_37033296_37034262	0.17	EPM2AIP1	EPM2A (laforin) interacting protein 1	1016	0.36
chr1_202777207_202777594	0.17	KDM5B	lysine (K)-specific demethylase 5B	146	0.92
chr8_125384746_125384961	0.17	TMEM65	transmembrane protein 65	80	0.98
chrX_19816618_19816769	0.17	SH3KBP1	SH3-domain kinase binding protein 1	1176	0.63
chr13_28000222_28001106	0.17	GTF3A	general transcription factor IIIA	1983	0.29
chr17_80817564_80818630	0.17	TBCD	tubulin folding cofactor D	173	0.94

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of BACH2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.1	0.4	GO:0019372	lipoxygenase pathway(GO:0019372)
0.1	0.2	GO:0048388	endosomal lumen acidification(GO:0048388)
0.1	0.3	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	0.2	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1	0.1	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.1	0.2	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.0	0.1	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0070669	response to interleukin-2(GO:0070669)
0.0	0.2	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.1	GO:0045591	positive regulation of regulatory T cell differentiation(GO:0045591)
0.0	0.1	GO:0000042	protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0	0.1	GO:0031573	intra-S DNA damage checkpoint(GO:0031573)
0.0	0.6	GO:0043303	mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.0	0.1	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.0	0.1	GO:0046021	regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0	0.2	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.1	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.3	GO:0051322	anaphase(GO:0051322)
0.0	0.1	GO:0031167	rRNA methylation(GO:0031167)
0.0	0.2	GO:0045576	mast cell activation(GO:0045576)
0.0	0.0	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.3	GO:0007096	regulation of exit from mitosis(GO:0007096)
0.0	0.1	GO:0045835	negative regulation of meiotic nuclear division(GO:0045835)
0.0	0.2	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.0	0.1	GO:0033632	regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0	0.1	GO:0045040	outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.1	GO:0034067	protein localization to Golgi apparatus(GO:0034067)
0.0	0.1	GO:0051775	response to redox state(GO:0051775)
0.0	0.1	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.2	GO:1904893	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.1	GO:0051532	NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0	0.1	GO:0008053	mitochondrial fusion(GO:0008053)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.1	GO:0021999	neural plate anterior/posterior regionalization(GO:0021999) neural plate regionalization(GO:0060897)
0.0	0.1	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.1	GO:0045007	depurination(GO:0045007)
0.0	0.1	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.2	GO:0048535	lymph node development(GO:0048535)
0.0	0.3	GO:0045671	negative regulation of osteoclast differentiation(GO:0045671)
0.0	0.1	GO:0048712	negative regulation of astrocyte differentiation(GO:0048712)
0.0	0.0	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.1	GO:0097094	cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0	0.0	GO:0002887	negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.0	0.1	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.0	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0034243	positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968) regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)
0.0	0.3	GO:0032233	positive regulation of actin filament bundle assembly(GO:0032233)
0.0	0.1	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0	0.0	GO:0002866	positive regulation of inflammatory response to antigenic stimulus(GO:0002863) positive regulation of acute inflammatory response to antigenic stimulus(GO:0002866) positive regulation of hypersensitivity(GO:0002885)
0.0	0.1	GO:0022030	cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0	0.0	GO:0051461	corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0	0.0	GO:0007262	STAT protein import into nucleus(GO:0007262)
0.0	0.0	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.0	GO:0071243	cellular response to arsenic-containing substance(GO:0071243)
0.0	0.0	GO:0009134	nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.0	0.1	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.0	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.1	GO:0000019	regulation of mitotic recombination(GO:0000019)
0.0	0.0	GO:0045990	carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015)
0.0	0.0	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.0	0.0	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.0	GO:0046599	regulation of centriole replication(GO:0046599)
0.0	0.1	GO:0042159	lipoprotein catabolic process(GO:0042159)
0.0	0.1	GO:0032988	ribonucleoprotein complex disassembly(GO:0032988)
0.0	0.0	GO:0045759	negative regulation of action potential(GO:0045759)
0.0	0.1	GO:0015712	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.1	GO:0045793	positive regulation of cell size(GO:0045793)
0.0	0.1	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
0.0	0.1	GO:0032875	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.1	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.1	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.0	GO:0051097	negative regulation of helicase activity(GO:0051097)
0.0	0.0	GO:0044415	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.0	GO:0060896	neural plate pattern specification(GO:0060896)
0.0	0.0	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.0	0.1	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.0	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.3	GO:0016236	macroautophagy(GO:0016236)
0.0	0.1	GO:0002507	tolerance induction(GO:0002507)
0.0	0.1	GO:0007158	neuron cell-cell adhesion(GO:0007158)
0.0	0.0	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.2	GO:0016254	preassembly of GPI anchor in ER membrane(GO:0016254)
0.0	0.0	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.0	0.0	GO:0006007	glucose catabolic process(GO:0006007)
0.0	0.0	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.1	GO:1903672	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.0	0.1	GO:0030224	monocyte differentiation(GO:0030224)
0.0	0.0	GO:0045410	positive regulation of interleukin-6 biosynthetic process(GO:0045410)
0.0	0.1	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.1	GO:0051044	positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0	0.0	GO:0060433	bronchus development(GO:0060433)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0005641	nuclear envelope lumen(GO:0005641)
0.1	0.4	GO:0043218	compact myelin(GO:0043218)
0.1	0.3	GO:0005826	actomyosin contractile ring(GO:0005826)
0.1	0.2	GO:0070062	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.2	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.6	GO:0001772	immunological synapse(GO:0001772)
0.0	0.3	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.2	GO:0031229	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.2	GO:0032585	multivesicular body membrane(GO:0032585)
0.0	0.2	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	0.1	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.0	0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.2	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.0	0.4	GO:0016328	lateral plasma membrane(GO:0016328)
0.0	0.1	GO:0045179	apical cortex(GO:0045179)
0.0	0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.1	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.1	GO:0034451	centriolar satellite(GO:0034451)
0.0	0.1	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.0	0.1	GO:0002102	podosome(GO:0002102)
0.0	0.1	GO:0000778	condensed nuclear chromosome kinetochore(GO:0000778)
0.0	0.1	GO:0042555	MCM complex(GO:0042555)
0.0	0.0	GO:0033150	cytoskeletal calyx(GO:0033150)
0.0	0.0	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.0	GO:0031931	TORC1 complex(GO:0031931)
0.0	0.0	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.0	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	0.0	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	0.1	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.1	0.3	GO:0055103	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.1	0.2	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1	0.2	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.1	0.4	GO:0016165	linoleate 13S-lipoxygenase activity(GO:0016165)
0.1	0.2	GO:0034648	histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0	0.3	GO:0005521	lamin binding(GO:0005521)
0.0	0.2	GO:0050733	RS domain binding(GO:0050733)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.2	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.1	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.1	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.0	0.1	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.0	0.1	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.1	GO:0099602	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0	0.1	GO:0032407	MutSalpha complex binding(GO:0032407)
0.0	0.1	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.1	GO:0004300	enoyl-CoA hydratase activity(GO:0004300)
0.0	0.1	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.1	GO:0016423	tRNA (guanine) methyltransferase activity(GO:0016423)
0.0	0.2	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.1	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.1	GO:0051400	BH domain binding(GO:0051400)
0.0	0.1	GO:0050309	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.1	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.1	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.3	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.0	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894)
0.0	0.3	GO:0004004	ATP-dependent RNA helicase activity(GO:0004004)
0.0	0.0	GO:0000400	four-way junction DNA binding(GO:0000400)
0.0	0.1	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.1	GO:0019864	IgG binding(GO:0019864)
0.0	0.0	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.0	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.3	GO:0048487	beta-tubulin binding(GO:0048487)
0.0	0.1	GO:0001012	RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0	0.0	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.0	GO:0097493	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.0	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.1	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	0.1	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.1	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	0.0	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.2	GO:0005212	structural constituent of eye lens(GO:0005212)
0.0	0.2	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	0.2	GO:0043022	ribosome binding(GO:0043022)
0.0	0.1	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.1	GO:0005337	nucleoside transmembrane transporter activity(GO:0005337)
0.0	0.0	GO:0034452	dynactin binding(GO:0034452)
0.0	0.2	GO:0070888	E-box binding(GO:0070888)
0.0	0.1	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.4	GO:0005080	protein kinase C binding(GO:0005080)
0.0	0.0	GO:0004875	complement receptor activity(GO:0004875)
0.0	0.1	GO:0051018	protein kinase A binding(GO:0051018)
0.0	0.1	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.0	0.1	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.6	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.0	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0	0.1	GO:0003709	obsolete RNA polymerase III transcription factor activity(GO:0003709)
0.0	0.0	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.0	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.0	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.0	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0005095	GTPase inhibitor activity(GO:0005095)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.6	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.3	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.3	PID IL5 PATHWAY	IL5-mediated signaling events
0.1	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.3	PID S1P S1P4 PATHWAY	S1P4 pathway
0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.7	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.4	PID TNF PATHWAY	TNF receptor signaling pathway
0.6	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.3	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.4	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.7	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.3	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
0.3	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.2	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.1	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.3	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.1	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.1	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.3	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.3	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.2	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)