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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for BHLHE22_BHLHA15_BHLHE23

Z-value: 0.61

Motif logo

Transcription factors associated with BHLHE22_BHLHA15_BHLHE23

Gene Symbol	Gene ID	Gene Info
BHLHE22 Ensembl NCBI GeneCards UniProt	ENSG00000180828.1	BHLHE22
BHLHA15 Ensembl NCBI GeneCards UniProt	ENSG00000180535.3	BHLHA15
BHLHE23 Ensembl NCBI GeneCards UniProt	ENSG00000125533.4	BHLHE23

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
BHLHA15	chr7_97793907_97794058	46757	0.129530	0.67	4.7e-02	Click!
BHLHA15	chr7_97840727_97841036	142	0.964058	0.65	5.6e-02	Click!
BHLHA15	chr7_97841044_97841241	403	0.864408	0.51	1.6e-01	Click!
BHLHA15	chr7_97794262_97794413	46402	0.130377	0.40	2.8e-01	Click!
BHLHA15	chr7_97841269_97841420	222	0.941200	-0.39	2.9e-01	Click!
BHLHE22	chr8_65492553_65493166	45	0.973369	0.58	1.0e-01	Click!
BHLHE22	chr8_65492035_65492186	704	0.701291	-0.42	2.6e-01	Click!
BHLHE22	chr8_65493405_65493750	763	0.482073	0.41	2.7e-01	Click!
BHLHE23	chr20_61640452_61640603	2140	0.299363	0.60	8.8e-02	Click!
BHLHE23	chr20_61613239_61613390	25073	0.130156	0.50	1.7e-01	Click!
BHLHE23	chr20_61640182_61640333	1870	0.329630	0.50	1.7e-01	Click!
BHLHE23	chr20_61656853_61657255	18667	0.168471	-0.34	3.6e-01	Click!
BHLHE23	chr20_61641850_61642001	3538	0.227710	0.20	6.1e-01	Click!

Activity of the BHLHE22_BHLHA15_BHLHE23 motif across conditions

Conditions sorted by the z-value of the BHLHE22_BHLHA15_BHLHE23 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_230307234_230307385	0.46	RP5-956O18.2		96920	0.07
chr10_63979683_63979834	0.44	RTKN2	rhotekin 2	16264	0.26
chr10_99302459_99302711	0.43	ANKRD2	ankyrin repeat domain 2 (stretch responsive muscle)	29613	0.09
chr1_185283352_185283831	0.41	IVNS1ABP	influenza virus NS1A binding protein	2870	0.28
chr18_56244732_56244930	0.40	RP11-126O1.2		20529	0.14
chr8_122738565_122738716	0.37	HAS2-AS1	HAS2 antisense RNA 1	84964	0.1
chr7_106299749_106299900	0.36	CCDC71L	coiled-coil domain containing 71-like	1618	0.46
chr2_200490274_200490425	0.35	SATB2	SATB homeobox 2	154360	0.04
chr10_89307360_89307659	0.35	ENSG00000222192	.	15434	0.21
chr3_192675469_192675839	0.34	MB21D2	Mab-21 domain containing 2	39704	0.21
chr7_97982123_97982542	0.31	RP11-307C18.1		30167	0.16
chr10_26775632_26775856	0.31	ENSG00000199733	.	22774	0.23
chr6_154780043_154780194	0.30	CNKSR3	CNKSR family member 3	19507	0.27
chr5_95295455_95295746	0.30	ELL2	elongation factor, RNA polymerase II, 2	1952	0.29
chr2_175264635_175264786	0.29	SCRN3	secernin 3	1787	0.32
chr8_107621172_107621323	0.28	OXR1	oxidation resistance 1	9107	0.27
chr5_3311555_3311706	0.28	IRX1	iroquois homeobox 1	284538	0.01
chr5_14184300_14184719	0.27	TRIO	trio Rho guanine nucleotide exchange factor	602	0.86
chr10_123458202_123458353	0.26	RP11-78A18.2		37541	0.2
chr5_73516595_73516746	0.26	ENSG00000222551	.	50920	0.17
chr3_66514964_66515132	0.26	LRIG1	leucine-rich repeats and immunoglobulin-like domains 1	36308	0.22
chr5_79251776_79251927	0.26	RP11-168A11.1		19449	0.2
chr6_49794571_49794884	0.26	RP3-417L20.4		9584	0.19
chr1_39175768_39175919	0.26	RRAGC	Ras-related GTP binding C	149652	0.04
chr19_33569394_33569545	0.26	GPATCH1	G patch domain containing 1	2317	0.26
chr13_33778604_33778877	0.26	STARD13	StAR-related lipid transfer (START) domain containing 13	1403	0.49
chr13_94069136_94069422	0.25	ENSG00000252365	.	48066	0.2
chr8_130734980_130735131	0.25	GSDMC	gasdermin C	64079	0.12
chr13_96295623_96295774	0.25	DZIP1	DAZ interacting zinc finger protein 1	181	0.96
chr2_145765254_145765507	0.25	ENSG00000253036	.	327258	0.01
chr4_156363784_156363935	0.25	MAP9	microtubule-associated protein 9	65737	0.13
chr17_73322605_73322792	0.24	GRB2	growth factor receptor-bound protein 2	4864	0.12
chr18_25444147_25444298	0.24	AC015933.2		90261	0.1
chr1_169014404_169014555	0.24	ENSG00000252987	.	22023	0.19
chr10_33527455_33527606	0.24	NRP1	neuropilin 1	25041	0.19
chr4_123775694_123776122	0.24	ENSG00000253069	.	27739	0.14
chr7_115816824_115816975	0.24	TFEC	transcription factor EC	16949	0.21
chr6_133006336_133006628	0.23	VNN1	vanin 1	28706	0.12
chr1_229642144_229642295	0.23	NUP133	nucleoporin 133kDa	1854	0.24
chr3_177978802_177979100	0.23	KCNMB2	potassium large conductance calcium-activated channel, subfamily M, beta member 2	11769	0.3
chr15_60898079_60898454	0.22	RORA	RAR-related orphan receptor A	12941	0.23
chr13_110064884_110065035	0.22	MYO16-AS1	MYO16 antisense RNA 1	211128	0.02
chr13_30419563_30419714	0.22	UBL3	ubiquitin-like 3	5183	0.32
chr8_23397961_23398112	0.22	SLC25A37	solute carrier family 25 (mitochondrial iron transporter), member 37	11463	0.16
chrX_133804801_133804952	0.22	PLAC1	placenta-specific 1	12363	0.2
chr10_122612352_122612503	0.22	WDR11	WD repeat domain 11	1428	0.37
chr14_51910059_51910325	0.22	FRMD6	FERM domain containing 6	45663	0.16
chr5_136751048_136751210	0.21	SPOCK1	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1	83118	0.1
chr9_35688355_35688710	0.21	TPM2	tropomyosin 2 (beta)	1368	0.2
chr12_33050043_33050552	0.20	PKP2	plakophilin 2	523	0.87
chr12_47898750_47898901	0.20	ENSG00000264906	.	140773	0.04
chr4_99214442_99214593	0.20	RP11-323J4.1		31736	0.19
chr6_52924116_52924267	0.20	ICK	intestinal cell (MAK-like) kinase	2377	0.21
chr8_18576139_18576290	0.20	RP11-161I2.1		2201	0.39
chr10_99082888_99083039	0.20	FRAT1	frequently rearranged in advanced T-cell lymphomas	3941	0.14
chr18_20558047_20558453	0.20	RBBP8	retinoblastoma binding protein 8	9445	0.15
chr2_12997455_12997766	0.19	ENSG00000264370	.	120117	0.06
chr1_68152763_68153190	0.19	GADD45A	growth arrest and DNA-damage-inducible, alpha	2092	0.36
chr3_156398302_156398550	0.19	TIPARP	TCDD-inducible poly(ADP-ribose) polymerase	529	0.81
chr6_132524074_132524225	0.19	ENSG00000265669	.	87746	0.09
chr8_131013169_131013320	0.19	ENSG00000253043	.	3603	0.21
chr12_8088033_8088689	0.19	SLC2A3	solute carrier family 2 (facilitated glucose transporter), member 3	421	0.8
chr8_22029446_22029597	0.19	BMP1	bone morphogenetic protein 1	6721	0.11
chr20_10501395_10501546	0.19	SLX4IP	SLX4 interacting protein	85519	0.09
chr12_82826657_82826808	0.19	METTL25	methyltransferase like 25	33594	0.21
chr6_17993424_17993603	0.19	KIF13A	kinesin family member 13A	5659	0.3
chr12_107617852_107618003	0.19	BTBD11	BTB (POZ) domain containing 11	94263	0.08
chr12_104196646_104196797	0.18	RP11-650K20.2		16667	0.13
chr20_19861450_19861601	0.18	RIN2	Ras and Rab interactor 2	5640	0.29
chr2_75873758_75873909	0.18	MRPL19	mitochondrial ribosomal protein L19	76	0.95
chr11_43902927_43903223	0.18	ALKBH3	alkB, alkylation repair homolog 3 (E. coli)	670	0.47
chr21_16431543_16432004	0.18	NRIP1	nuclear receptor interacting protein 1	5353	0.3
chr17_71817273_71817424	0.18	SDK2	sidekick cell adhesion molecule 2	177120	0.03
chr4_99576885_99577036	0.18	TSPAN5	tetraspanin 5	1826	0.38
chr5_162930555_162931177	0.18	MAT2B	methionine adenosyltransferase II, beta	746	0.62
chr2_123392168_123392319	0.18	TSN	translin	878496	0.0
chr9_1173997_1174148	0.17	DMRT2	doublesex and mab-3 related transcription factor 2	122458	0.06
chr21_17907841_17908039	0.17	ENSG00000207638	.	3469	0.26
chr4_89394952_89395117	0.17	HERC5	HECT and RLD domain containing E3 ubiquitin protein ligase 5	6027	0.17
chr17_44805262_44805413	0.17	NSF	N-ethylmaleimide-sensitive factor	1415	0.5
chrX_153023566_153023717	0.17	PLXNB3	plexin B3	6010	0.1
chr8_119344904_119345055	0.17	AC023590.1	Uncharacterized protein	50498	0.19
chr1_201323781_201323932	0.17	TNNT2	troponin T type 2 (cardiac)	18526	0.16
chr15_33111539_33111777	0.17	FMN1	formin 1	68797	0.1
chr1_36614255_36614499	0.17	TRAPPC3	trafficking protein particle complex 3	675	0.62
chr6_139561908_139562059	0.17	RP1-225E12.2		1541	0.41
chr2_207024982_207025205	0.17	EEF1B2	eukaryotic translation elongation factor 1 beta 2	762	0.32
chr1_86969615_86969766	0.17	CLCA1	chloride channel accessory 1	35164	0.16
chr3_183530706_183530857	0.17	YEATS2-AS1	YEATS2 antisense RNA 1	2210	0.22
chr12_46659525_46659676	0.17	SLC38A1	solute carrier family 38, member 1	1884	0.48
chr11_133450172_133450323	0.17	OPCML	opioid binding protein/cell adhesion molecule-like	47833	0.17
chr1_246646221_246646372	0.16	SMYD3	SET and MYND domain containing 3	771	0.7
chr5_43310867_43311162	0.16	HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	2312	0.32
chr5_137674413_137674698	0.16	CDC25C	cell division cycle 25C	511	0.47
chr10_134388453_134389007	0.16	INPP5A	inositol polyphosphate-5-phosphatase, 40kDa	32700	0.18
chr5_173399860_173400035	0.16	C5orf47	chromosome 5 open reading frame 47	16215	0.22
chr22_41253195_41254018	0.16	XPNPEP3	X-prolyl aminopeptidase (aminopeptidase P) 3, putative	504	0.47
chr10_13828862_13829013	0.16	RP11-353M9.1		57554	0.1
chr2_201622052_201622203	0.16	ENSG00000201737	.	18180	0.14
chr6_21587871_21588206	0.16	SOX4	SRY (sex determining region Y)-box 4	5934	0.35
chr3_106308061_106308212	0.16	ENSG00000200610	.	73392	0.12
chr22_19074199_19074350	0.16	AC004471.9		34768	0.09
chr5_40490586_40490737	0.16	ENSG00000199552	.	164404	0.03
chr14_37131505_37132074	0.16	PAX9	paired box 9	10	0.98
chr15_49913739_49914013	0.16	DTWD1	DTW domain containing 1	580	0.53
chr4_11652300_11652527	0.16	HS3ST1	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	221024	0.02
chr12_109090441_109090824	0.16	CORO1C	coronin, actin binding protein, 1C	454	0.79
chr3_95257506_95257657	0.16	ENSG00000221477	.	628165	0.0
chr1_192776419_192777001	0.15	RGS2	regulator of G-protein signaling 2, 24kDa	1461	0.52
chr9_127030053_127030414	0.15	RP11-121A14.3		5078	0.19
chr4_105315936_105316087	0.15	ENSG00000272082	.	96022	0.08
chr3_37978259_37978410	0.15	CTDSPL	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like	27736	0.14
chr6_162040062_162040271	0.15	ENSG00000221021	.	4068	0.38
chr1_94750293_94750444	0.15	ARHGAP29	Rho GTPase activating protein 29	47179	0.16
chr2_75834857_75835085	0.15	ENSG00000221638	.	20108	0.12
chr10_47242799_47243052	0.15	BMS1P2	BMS1 pseudogene 2	1018	0.47
chr1_89060919_89061070	0.15	RP11-76N22.2		24451	0.24
chr20_44065109_44065260	0.15	AL031663.2	CDNA FLJ26875 fis, clone PRS08969; Uncharacterized protein	8887	0.11
chr7_7681092_7681243	0.15	RPA3	replication protein A3, 14kDa	564	0.83
chrX_105854737_105855044	0.15	CXorf57	chromosome X open reading frame 57	270	0.94
chr11_66795405_66795556	0.15	SYT12	synaptotagmin XII	449	0.77
chrX_99904040_99904245	0.15	SRPX2	sushi-repeat containing protein, X-linked 2	4927	0.19
chr1_151513093_151513944	0.15	RP11-74C1.4		526	0.48
chr2_85199284_85199564	0.15	KCMF1	potassium channel modulatory factor 1	100	0.98
chr1_195606757_195606908	0.15	ENSG00000265108	.	511021	0.0
chrX_77040024_77040561	0.15	ATRX	alpha thalassemia/mental retardation syndrome X-linked	1410	0.49
chr19_11096722_11096873	0.15	SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	1969	0.25
chr4_177710355_177710506	0.14	VEGFC	vascular endothelial growth factor C	3451	0.38
chrX_13106517_13106711	0.14	FAM9C	family with sequence similarity 9, member C	43813	0.18
chr11_34367200_34367440	0.14	ABTB2	ankyrin repeat and BTB (POZ) domain containing 2	11482	0.26
chr12_57077777_57078354	0.14	PTGES3	prostaglandin E synthase 3 (cytosolic)	3881	0.14
chr1_184823664_184823815	0.14	ENSG00000252222	.	33116	0.18
chr20_10741569_10741720	0.14	JAG1	jagged 1	86950	0.09
chrX_45182977_45183128	0.14	RP11-342D14.1		3349	0.38
chr1_89457123_89457381	0.14	CCBL2	cysteine conjugate-beta lyase 2	1035	0.37
chr6_53670019_53670170	0.14	LRRC1	leucine rich repeat containing 1	10206	0.21
chr2_100427985_100428136	0.14	AFF3	AF4/FMR2 family, member 3	233228	0.02
chr7_15725909_15726109	0.14	MEOX2	mesenchyme homeobox 2	428	0.88
chr9_132404432_132404583	0.14	ASB6	ankyrin repeat and SOCS box containing 6	63	0.95
chr6_21191491_21191642	0.14	ENSG00000252046	.	197767	0.03
chr11_115530687_115530852	0.14	ENSG00000239153	.	32866	0.25
chr3_160787530_160787756	0.14	B3GALNT1	beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)	31312	0.2
chr1_32168571_32169014	0.14	COL16A1	collagen, type XVI, alpha 1	976	0.48
chr2_40662150_40662301	0.14	SLC8A1	solute carrier family 8 (sodium/calcium exchanger), member 1	4781	0.35
chr15_78251949_78252110	0.14	ADAMTS7P3	ADAMTS7 pseudogene 3	16355	0.11
chr3_58316326_58316512	0.14	PXK	PX domain containing serine/threonine kinase	2188	0.31
chr4_170190845_170191352	0.14	SH3RF1	SH3 domain containing ring finger 1	10	0.99
chr7_92241576_92241727	0.13	FAM133B	family with sequence similarity 133, member B	21943	0.2
chr6_132713364_132713525	0.13	MOXD1	monooxygenase, DBH-like 1	9170	0.27
chrX_40048176_40048340	0.13	BCOR	BCL6 corepressor	11676	0.29
chr9_35746072_35746267	0.13	RGP1	RGP1 retrograde golgi transport homolog (S. cerevisiae)	3034	0.1
chr19_52873836_52874044	0.13	ZNF880	zinc finger protein 880	736	0.53
chr2_242227382_242227533	0.13	HDLBP	high density lipoprotein binding protein	14682	0.14
chr2_197089963_197090119	0.13	ENSG00000239161	.	9995	0.19
chr13_41765022_41765570	0.13	KBTBD7	kelch repeat and BTB (POZ) domain containing 7	3406	0.21
chr6_12293530_12293681	0.13	EDN1	endothelin 1	3009	0.39
chr18_55889704_55889927	0.13	NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	1012	0.61
chr12_94852826_94853545	0.13	CCDC41	coiled-coil domain containing 41	537	0.82
chrX_149534374_149534815	0.13	MAMLD1	mastermind-like domain containing 1	2908	0.38
chr9_113205949_113206100	0.13	SVEP1	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	15986	0.24
chr20_9389767_9389966	0.13	PLCB4	phospholipase C, beta 4	101419	0.07
chr7_41738474_41738677	0.13	INHBA	inhibin, beta A	1632	0.38
chr3_4793867_4794159	0.13	ENSG00000239126	.	126373	0.05
chr1_61330866_61331017	0.13	NFIA	nuclear factor I/A	10	0.99
chr9_107669806_107669965	0.13	RP11-217B7.2		19949	0.21
chr11_27492592_27492931	0.13	RP11-159H22.2		515	0.65
chr12_48082357_48082508	0.13	RPAP3	RNA polymerase II associated protein 3	17337	0.17
chr3_114865060_114865714	0.13	ZBTB20	zinc finger and BTB domain containing 20	731	0.81
chr11_131618597_131618988	0.13	NTM	neurotrimin	87904	0.1
chr5_75842727_75842878	0.13	IQGAP2	IQ motif containing GTPase activating protein 2	432	0.88
chr19_16195500_16195773	0.13	TPM4	tropomyosin 4	3103	0.21
chr6_118971873_118972263	0.13	CEP85L	centrosomal protein 85kDa-like	952	0.71
chr6_36590990_36591141	0.13	ENSG00000263894	.	776	0.56
chr5_17805402_17805553	0.13	ENSG00000212278	.	430755	0.01
chr1_225968168_225968319	0.13	SRP9	signal recognition particle 9kDa	2606	0.22
chr18_9138515_9138757	0.13	ANKRD12	ankyrin repeat domain 12	1075	0.42
chr8_76319339_76319966	0.13	HNF4G	hepatocyte nuclear factor 4, gamma	619	0.85
chr4_83280489_83280640	0.13	HNRNPD	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	228	0.93
chr4_157867457_157867608	0.13	PDGFC	platelet derived growth factor C	24523	0.2
chr1_109583292_109583606	0.13	WDR47	WD repeat domain 47	720	0.6
chr12_46762957_46763490	0.12	RP11-474P2.2		2023	0.36
chr1_146640938_146641089	0.12	PRKAB2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	3033	0.2
chr5_36664801_36664952	0.12	SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3	56445	0.14
chr12_78683757_78683908	0.12	NAV3	neuron navigator 3	90976	0.1
chr2_201270113_201270684	0.12	SPATS2L	spermatogenesis associated, serine-rich 2-like	12598	0.18
chr5_95170159_95170387	0.12	GLRX	glutaredoxin (thioltransferase)	11564	0.14
chr4_166252557_166253372	0.12	MSMO1	methylsterol monooxygenase 1	3885	0.25
chr4_169490767_169491028	0.12	PALLD	palladin, cytoskeletal associated protein	58178	0.12
chr18_56215999_56216150	0.12	RP11-126O1.2		8228	0.17
chrX_57622345_57622884	0.12	ZXDB	zinc finger, X-linked, duplicated B	4345	0.37
chr4_138281360_138281511	0.12	ENSG00000222526	.	132153	0.06
chr17_46048416_46049087	0.12	CDK5RAP3	CDK5 regulatory subunit associated protein 3	234	0.85
chr7_41426318_41426600	0.12	INHBA-AS1	INHBA antisense RNA 1	307055	0.01
chrX_33225807_33225958	0.12	DMD	dystrophin	3547	0.4
chr11_100761786_100762126	0.12	ARHGAP42	Rho GTPase activating protein 42	22275	0.19
chr15_56204998_56205389	0.12	NEDD4	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	2659	0.34
chr1_211056531_211056682	0.12	KCNH1-IT1	KCNH1 intronic transcript 1 (non-protein coding)	250110	0.02
chr15_63448807_63449350	0.12	RPS27L	ribosomal protein S27-like	105	0.97
chr2_145153762_145153913	0.12	ZEB2	zinc finger E-box binding homeobox 2	33756	0.21
chr1_159819723_159819925	0.12	ENSG00000212161	.	1938	0.18

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of BHLHE22_BHLHA15_BHLHE23

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.1	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.1	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.1	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.1	GO:0060584	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0	0.1	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:0000730	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.1	GO:0071372	cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0	0.1	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.1	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.1	GO:0002328	pro-B cell differentiation(GO:0002328)
0.0	0.1	GO:0043551	regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0	0.0	GO:0071436	sodium ion export(GO:0071436)
0.0	0.1	GO:1903332	regulation of protein folding(GO:1903332)
0.0	0.1	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.1	GO:0022038	corpus callosum development(GO:0022038)
0.0	0.1	GO:0043922	negative regulation by host of viral transcription(GO:0043922)
0.0	0.1	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.1	GO:0006999	nuclear pore organization(GO:0006999)
0.0	0.1	GO:0032780	negative regulation of ATPase activity(GO:0032780)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.0	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.0	GO:0009191	nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.0	0.1	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.1	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.0	0.1	GO:2000178	negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0	0.0	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
0.0	0.0	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.1	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.1	GO:1902808	traversing start control point of mitotic cell cycle(GO:0007089) positive regulation of G1/S transition of mitotic cell cycle(GO:1900087) positive regulation of cell cycle G1/S phase transition(GO:1902808)
0.0	0.0	GO:0006434	seryl-tRNA aminoacylation(GO:0006434)
0.0	0.2	GO:0048745	smooth muscle tissue development(GO:0048745)
0.0	0.0	GO:0018242	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.2	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0	0.1	GO:0006787	porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0	0.0	GO:0045002	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0	0.0	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.0	0.1	GO:0033137	negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0	0.1	GO:0030212	hyaluronan metabolic process(GO:0030212)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0030008	TRAPP complex(GO:0030008)
0.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.1	GO:0071778	obsolete WINAC complex(GO:0071778)
0.1	GO:0005662	DNA replication factor A complex(GO:0005662)
0.1	GO:0005593	FACIT collagen trimer(GO:0005593)
0.1	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.1	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.2	GO:0005811	lipid particle(GO:0005811)
0.0	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.1	GO:0048188	Set1C/COMPASS complex(GO:0048188)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.1	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0	0.2	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0035514	DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0008494	translation activator activity(GO:0008494)
0.0	0.1	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.1	GO:0032558	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.1	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.1	GO:0031708	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.0	GO:0016212	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.0	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.2	GO:0042162	telomeric DNA binding(GO:0042162)
0.0	0.1	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.0	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.0	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0004090	carbonyl reductase (NADPH) activity(GO:0004090)
0.0	0.0	GO:0004500	dopamine beta-monooxygenase activity(GO:0004500)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.1	GO:0016944	obsolete RNA polymerase II transcription elongation factor activity(GO:0016944)
0.0	0.1	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.0	GO:0004828	serine-tRNA ligase activity(GO:0004828)
0.0	0.1	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.0	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.0	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.0	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.0	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.0	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.0	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.2	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.1	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.1	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism