Project
ENCODE: H3K4me3 ChIP-Seq of primary human cells
Navigation
Downloads
Logo
CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for BHLHE40

Z-value: 0.78

Motif logo

logo of

Transcription factors associated with BHLHE40

Gene Symbol Gene ID Gene Info
BHLHE40
ENSG00000134107.4 BHLHE40

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
BHLHE40chr3_4992051_4992202286750.163351-0.713.1e-02Click!
BHLHE40chr3_5019013_501952715310.376496-0.674.7e-02Click!
BHLHE40chr3_5019531_501971511780.450298-0.324.1e-01Click!
BHLHE40chr3_5020528_50206791980.899685-0.265.0e-01Click!
BHLHE40chr3_5019761_50205126650.639724-0.039.3e-01Click!

Activity of the BHLHE40 motif across conditions

Conditions sorted by the z-value of the BHLHE40 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr16_2077067_2078193 0.41 SLC9A3R2
 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
 701
 0.35
chr10_128076215_128076453 0.31 ADAM12
 ADAM metallopeptidase domain 12
 690
 0.79
chr13_102105916_102106117 0.30 ITGBL1
 integrin, beta-like 1 (with EGF-like repeat domains)
 998
 0.66
chr1_68297532_68297957 0.30 GNG12-AS1
 GNG12 antisense RNA 1
 242
 0.9
chr22_25507059_25507657 0.30 CTA-221G9.11
1301
 0.51
chr10_63809082_63810748 0.27 ARID5B
 AT rich interactive domain 5B (MRF1-like)
 945
 0.69
chr3_36422437_36422689 0.27 STAC
 SH3 and cysteine rich domain
 498
 0.89
chr4_114899856_114900283 0.27 ARSJ
 arylsulfatase family, member J
 83
 0.98
chr12_124872056_124872210 0.26 NCOR2
 nuclear receptor corepressor 2
 1237
 0.6
chr10_112113035_112113246 0.25 SMNDC1
 survival motor neuron domain containing 1
 48431
 0.14
chr2_12860250_12860601 0.25 TRIB2
 tribbles pseudokinase 2
 2061
 0.41
chr3_197326133_197326372 0.24 BDH1
 3-hydroxybutyrate dehydrogenase, type 1
 26058
 0.17
chr8_101859554_101859783 0.24 ENSG00000222795
 .
 15580
 0.19
chr17_29887977_29888214 0.24 ENSG00000207614
 .
 1080
 0.35
chr1_86047684_86048329 0.24 CYR61
 cysteine-rich, angiogenic inducer, 61
 1562
 0.37
chr9_21989659_21989874 0.23 CDKN2A
 cyclin-dependent kinase inhibitor 2A
 4644
 0.16
chr18_46473562_46473713 0.23 SMAD7
 SMAD family member 7
 1238
 0.56
chr21_46727414_46727565 0.22 ENSG00000215447
 .
 19522
 0.16
chr15_60682035_60682438 0.22 ANXA2
 annexin A2
 1090
 0.63
chrX_17395110_17395408 0.22 NHS
 Nance-Horan syndrome (congenital cataracts and dental anomalies)
 1716
 0.4
chr8_145046455_145046834 0.22 PLEC
 plectin
 1053
 0.34
chr7_116166933_116167162 0.22 CAV1
 caveolin 1, caveolae protein, 22kDa
 700
 0.64
chr11_69460305_69460629 0.22 CCND1
 cyclin D1
 4493
 0.24
chr11_118791642_118792157 0.21 BCL9L
 B-cell CLL/lymphoma 9-like
 2286
 0.14
chr21_47519356_47519507 0.21 COL6A2
 collagen, type VI, alpha 2
 720
 0.56
chr10_52176688_52176970 0.21 AC069547.2
 Uncharacterized protein
 24063
 0.19
chr8_494269_494491 0.21 TDRP
 testis development related protein
 457
 0.88
chr4_20256302_20256578 0.20 SLIT2
 slit homolog 2 (Drosophila)
 103
 0.98
chr13_100636352_100636503 0.20 ZIC2
 Zic family member 2
 2401
 0.28
chr3_52567337_52567575 0.20 NT5DC2
 5'-nucleotidase domain containing 2
 91
 0.94
chr9_130737928_130738103 0.20 FAM102A
 family with sequence similarity 102, member A
 4777
 0.13
chr5_179778925_179779076 0.20 GFPT2
 glutamine-fructose-6-phosphate transaminase 2
 900
 0.63
chr11_114168914_114169158 0.20 NNMT
 nicotinamide N-methyltransferase
 163
 0.96
chr13_34184631_34184800 0.20 RFC3
 replication factor C (activator 1) 3, 38kDa
 207471
 0.02
chr17_40932934_40933198 0.20 WNK4
 WNK lysine deficient protein kinase 4
 370
 0.71
chr7_94028286_94028494 0.20 COL1A2
 collagen, type I, alpha 2
 4517
 0.32
chr17_74697030_74697413 0.20 ENSG00000212418
 .
 2588
 0.13
chr7_42275396_42275690 0.19 GLI3
 GLI family zinc finger 3
 1069
 0.7
chr5_73839584_73839978 0.19 HEXB
 hexosaminidase B (beta polypeptide)
 96067
 0.08
chr9_35491110_35491278 0.19 RUSC2
 RUN and SH3 domain containing 2
 1070
 0.5
chr16_86695305_86695456 0.19 FOXL1
 forkhead box L1
 83265
 0.09
chr5_98111445_98111873 0.19 RGMB
 repulsive guidance molecule family member b
 2320
 0.3
chr2_145594298_145594531 0.19 ZEB2
 zinc finger E-box binding homeobox 2
 315793
 0.01
chr6_143259748_143259920 0.19 HIVEP2
 human immunodeficiency virus type I enhancer binding protein 2
 6504
 0.28
chrX_105970264_105970617 0.19 RNF128
 ring finger protein 128, E3 ubiquitin protein ligase
 546
 0.83
chr16_11422925_11423155 0.19 RMI2
 RecQ mediated genome instability 2
 12404
 0.08
chr14_42074686_42074934 0.19 LRFN5
 leucine rich repeat and fibronectin type III domain containing 5
 1963
 0.41
chr15_85525955_85526270 0.19 PDE8A
 phosphodiesterase 8A
 900
 0.6
chr2_72370559_72370716 0.18 CYP26B1
 cytochrome P450, family 26, subfamily B, polypeptide 1
 424
 0.92
chr11_79150433_79150655 0.18 TENM4
 teneurin transmembrane protein 4
 1151
 0.54
chr1_32169073_32169273 0.18 COL16A1
 collagen, type XVI, alpha 1
 595
 0.68
chr2_216301575_216301809 0.18 AC012462.1
716
 0.48
chr15_68723417_68723663 0.18 ITGA11
 integrin, alpha 11
 952
 0.69
chr20_57426029_57426307 0.18 GNAS-AS1
 GNAS antisense RNA 1
 210
 0.89
chr12_49318526_49318771 0.18 FKBP11
 FK506 binding protein 11, 19 kDa
 102
 0.91
chr19_6531750_6531901 0.18 TNFSF9
 tumor necrosis factor (ligand) superfamily, member 9
 815
 0.47
chr8_37350120_37350468 0.18 RP11-150O12.6
24245
 0.24
chr9_98272289_98272560 0.18 PTCH1
 patched 1
 1481
 0.34
chr2_151337593_151337891 0.17 RND3
 Rho family GTPase 3
 4154
 0.38
chr5_121648324_121648736 0.17 SNCAIP
 synuclein, alpha interacting protein
 268
 0.87
chr10_44069814_44070416 0.17 ZNF239
 zinc finger protein 239
 49
 0.98
chr5_54281245_54281752 0.17 ESM1
 endothelial cell-specific molecule 1
 7
 0.97
chr9_2157555_2157766 0.17 SMARCA2
 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
 20
 0.98
chr17_32906311_32906556 0.17 C17orf102
 chromosome 17 open reading frame 102
 45
 0.97
chr1_56441058_56441209 0.16 PIGQP1
 phosphatidylinositol glycan anchor biosynthesis, class Q pseudogene 1
 36180
 0.24
chr20_31062458_31062723 0.16 C20orf112
 chromosome 20 open reading frame 112
 8684
 0.18
chr11_133917712_133918072 0.16 JAM3
 junctional adhesion molecule 3
 20928
 0.21
chr12_131322718_131323133 0.16 STX2
 syntaxin 2
 814
 0.6
chr5_139724897_139725179 0.16 HBEGF
 heparin-binding EGF-like growth factor
 1150
 0.36
chr14_99740123_99740356 0.16 BCL11B
 B-cell CLL/lymphoma 11B (zinc finger protein)
 2378
 0.32
chr14_52121858_52122101 0.16 FRMD6
 FERM domain containing 6
 3281
 0.25
chr12_125395384_125395562 0.16 UBC
 ubiquitin C
 3147
 0.2
chrX_17609979_17610432 0.16 NHS-AS1
 NHS antisense RNA 1
 34697
 0.17
chr5_136645949_136646125 0.16 SPOCK1
 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
 3190
 0.39
chr4_99575076_99575227 0.16 TSPAN5
 tetraspanin 5
 3635
 0.27
chr5_140857632_140858335 0.16 ENSG00000242020
 .
 900
 0.34
chr6_132271257_132271718 0.16 RP11-69I8.3
599
 0.62
chr7_142507018_142507186 0.15 PRSS3P2
 protease, serine, 3 pseudogene 2
 25971
 0.15
chr1_85665779_85666437 0.15 SYDE2
 synapse defective 1, Rho GTPase, homolog 2 (C. elegans)
 621
 0.72
chr10_93058252_93058702 0.15 PCGF5
 polycomb group ring finger 5
 77932
 0.11
chr3_116163640_116163792 0.15 LSAMP
 limbic system-associated membrane protein
 114
 0.98
chr16_73266705_73266923 0.15 C16orf47
 chromosome 16 open reading frame 47
 88468
 0.1
chr17_1081882_1082496 0.15 ABR
 active BCR-related
 889
 0.58
chr3_47051058_47051537 0.15 NBEAL2
 neurobeachin-like 2
 4526
 0.22
chr11_469322_469620 0.15 RP13-317D12.3
5572
 0.1
chr1_42383823_42384248 0.15 HIVEP3
 human immunodeficiency virus type I enhancer binding protein 3
 134
 0.98
chr7_27940568_27941235 0.15 ENSG00000265382
 .
 20795
 0.23
chr7_73133202_73133898 0.15 STX1A
 syntaxin 1A (brain)
 411
 0.72
chr10_13932932_13933715 0.15 FRMD4A
 FERM domain containing 4A
 32411
 0.2
chr22_46462679_46462866 0.15 RP6-109B7.4
2999
 0.14
chr9_130616400_130616906 0.15 ENG
 endoglin
 262
 0.8
chr2_241376186_241376470 0.15 GPC1
 glypican 1
 1240
 0.43
chr1_40960645_40960796 0.15 RP11-656D10.3
13613
 0.1
chr21_35319646_35320126 0.15 LINC00649
 long intergenic non-protein coding RNA 649
 1144
 0.46
chr1_162532826_162532977 0.14 UAP1
 UDP-N-acteylglucosamine pyrophosphorylase 1
 1578
 0.3
chr16_10934760_10934911 0.14 TVP23A
 trans-golgi network vesicle protein 23 homolog A (S. cerevisiae)
 22193
 0.15
chr4_147560181_147560405 0.14 ENSG00000264323
 .
 120
 0.68
chr5_158488903_158489314 0.14 EBF1
 early B-cell factor 1
 37593
 0.17
chr12_8814552_8814785 0.14 MFAP5
 microfibrillar associated protein 5
 1
 0.97
chr8_24799151_24799367 0.14 CTD-2168K21.2
14876
 0.17
chr5_159214342_159214493 0.14 ADRA1B
 adrenoceptor alpha 1B
 129373
 0.05
chr8_72459619_72459990 0.14 RP11-1102P16.1
 Uncharacterized protein
 88
 0.98
chr4_7907648_7907905 0.14 AC097381.1
32952
 0.16
chr5_37839189_37839372 0.14 GDNF
 glial cell derived neurotrophic factor
 502
 0.85
chr5_146889201_146889394 0.14 DPYSL3
 dihydropyrimidinase-like 3
 322
 0.94
chr20_62372328_62372826 0.14 SLC2A4RG
 SLC2A4 regulator
 1363
 0.22
chr6_169652381_169652976 0.14 THBS2
 thrombospondin 2
 432
 0.89
chr1_46597349_46597672 0.14 PIK3R3
 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
 778
 0.56
chr13_58203621_58204059 0.14 PCDH17
 protocadherin 17
 2815
 0.43
chr19_51433227_51433378 0.14 KLK4
 kallikrein-related peptidase 4
 19308
 0.07
chr17_47210248_47210565 0.14 B4GALNT2
 beta-1,4-N-acetyl-galactosaminyl transferase 2
 77
 0.97
chr3_32021239_32021390 0.14 OSBPL10
 oxysterol binding protein-like 10
 1478
 0.36
chrX_135230110_135230418 0.13 FHL1
 four and a half LIM domains 1
 6
 0.98
chr14_29242746_29242955 0.13 C14orf23
 chromosome 14 open reading frame 23
 849
 0.55
chr6_28456937_28457274 0.13 GPX6
 glutathione peroxidase 6 (olfactory)
 26459
 0.14
chr14_99655246_99655958 0.13 AL162151.4
30849
 0.2
chr7_150716014_150716204 0.13 ATG9B
 autophagy related 9B
 5477
 0.1
chr18_55863472_55863729 0.13 RP11-718I15.1
672
 0.47
chr11_120080847_120081389 0.13 OAF
 OAF homolog (Drosophila)
 357
 0.86
chr12_39836327_39837104 0.13 KIF21A
 kinesin family member 21A
 57
 0.7
chr20_52839047_52839198 0.13 PFDN4
 prefoldin subunit 4
 14736
 0.25
chr17_52978401_52978600 0.13 TOM1L1
 target of myb1 (chicken)-like 1
 5
 0.99
chr4_142693171_142693378 0.13 IL15
 interleukin 15
 50972
 0.19
chr12_52257745_52258098 0.13 ANKRD33
 ankyrin repeat domain 33
 23823
 0.16
chr11_66090538_66090689 0.13 CD248
 CD248 molecule, endosialin
 6098
 0.07
chr8_96036821_96037145 0.13 NDUFAF6
 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
 231
 0.92
chr16_1233245_1233443 0.13 RP11-616M22.2
23168
 0.08
chr12_59311566_59311750 0.13 LRIG3
 leucine-rich repeats and immunoglobulin-like domains 3
 1669
 0.41
chr6_133890397_133891036 0.12 RP3-323P13.2
57850
 0.15
chr12_3278190_3278426 0.12 TSPAN9-IT1
 TSPAN9 intronic transcript 1 (non-protein coding)
 19345
 0.21
chr8_1771644_1772131 0.12 ARHGEF10
 Rho guanine nucleotide exchange factor (GEF) 10
 255
 0.93
chr1_23751694_23751845 0.12 TCEA3
 transcription elongation factor A (SII), 3
 536
 0.73
chrX_66764418_66765028 0.12 AR
 androgen receptor
 61
 0.99
chr4_143300832_143301092 0.12 INPP4B
 inositol polyphosphate-4-phosphatase, type II, 105kDa
 51450
 0.19
chr11_10679210_10679389 0.12 MRVI1
 murine retrovirus integration site 1 homolog
 5376
 0.21
chr17_2077835_2078037 0.12 SMG6
 SMG6 nonsense mediated mRNA decay factor
 1464
 0.31
chr15_73979338_73979524 0.12 CD276
 CD276 molecule
 2084
 0.37
chr22_35747250_35747434 0.12 ENSG00000266320
 .
 15709
 0.16
chr9_22006120_22006693 0.12 CDKN2B
 cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
 2546
 0.22
chrX_54509628_54509782 0.12 FGD1
 FYVE, RhoGEF and PH domain containing 1
 12894
 0.21
chr13_74710745_74710896 0.12 KLF12
 Kruppel-like factor 12
 2426
 0.45
chr9_95970167_95970323 0.12 WNK2
 WNK lysine deficient protein kinase 2
 23020
 0.19
chr16_73097793_73098198 0.12 ZFHX3
 zinc finger homeobox 3
 4398
 0.27
chr6_28410806_28411495 0.12 ZSCAN23
 zinc finger and SCAN domain containing 23
 94
 0.96
chr9_98269032_98269993 0.12 PTCH1
 patched 1
 31
 0.95
chr2_121692732_121692961 0.12 ENSG00000221321
 .
 99803
 0.08
chr4_20252886_20253037 0.12 SLIT2
 slit homolog 2 (Drosophila)
 1922
 0.5
chr6_1554751_1555484 0.12 ENSG00000243439
 .
 47560
 0.16
chr2_216289836_216290038 0.12 FN1
 fibronectin 1
 10853
 0.22
chr5_172160432_172160661 0.12 RP11-779O18.1
24683
 0.12
chr3_126853954_126854422 0.12 C3orf56
 chromosome 3 open reading frame 56
 57786
 0.13
chr1_151966472_151966834 0.12 S100A10
 S100 calcium binding protein A10
 213
 0.65
chr3_115507533_115507684 0.12 ENSG00000243359
 .
 49107
 0.19
chr17_77788750_77788949 0.12 ENSG00000238331
 .
 4371
 0.16
chr1_27357912_27358708 0.12 FAM46B
 family with sequence similarity 46, member B
 18983
 0.16
chr5_155109546_155109697 0.12 ENSG00000200275
 .
 162826
 0.04
chr1_70509689_70509840 0.12 RP11-181B18.1
12859
 0.27
chr1_53664021_53664172 0.12 CPT2
 carnitine palmitoyltransferase 2
 1995
 0.2
chr16_29912249_29912746 0.12 ASPHD1
 aspartate beta-hydroxylase domain containing 1
 456
 0.59
chr19_10542095_10542754 0.12 PDE4A
 phosphodiesterase 4A, cAMP-specific
 687
 0.54
chr2_239770660_239770811 0.12 TWIST2
 twist family bHLH transcription factor 2
 14062
 0.25
chr16_15529020_15529579 0.12 C16orf45
 chromosome 16 open reading frame 45
 967
 0.56
chr22_46480425_46480827 0.12 FLJ27365
 hsa-mir-4763
 1257
 0.28
chr5_114795809_114796168 0.12 FEM1C
 fem-1 homolog c (C. elegans)
 84603
 0.08
chr19_48893644_48893831 0.12 KDELR1
 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
 375
 0.76
chr1_6557689_6557891 0.12 PLEKHG5
 pleckstrin homology domain containing, family G (with RhoGef domain) member 5
 306
 0.84
chr15_96877328_96877479 0.12 ENSG00000222651
 .
 913
 0.39
chr3_184036946_184037180 0.12 EIF4G1
 eukaryotic translation initiation factor 4 gamma, 1
 76
 0.94
chr9_101557838_101558540 0.11 ANKS6
 ankyrin repeat and sterile alpha motif domain containing 6
 605
 0.76
chr19_44285188_44285480 0.11 KCNN4
 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
 75
 0.96
chr8_132053641_132053792 0.11 ADCY8
 adenylate cyclase 8 (brain)
 956
 0.71
chr6_169889311_169889462 0.11 WDR27
 WD repeat domain 27
 171402
 0.03
chr15_29396229_29396380 0.11 APBA2
 amyloid beta (A4) precursor protein-binding, family A, member 2
 59777
 0.14
chrX_30906152_30906450 0.11 TAB3
 TGF-beta activated kinase 1/MAP3K7 binding protein 3
 20982
 0.19
chr12_49660713_49661148 0.11 TUBA1C
 tubulin, alpha 1c
 2066
 0.18
chr20_55207246_55207474 0.11 TFAP2C
 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
 1422
 0.37
chr19_13166352_13166593 0.11 AC007787.2
15716
 0.1
chr11_130641825_130641976 0.11 C11orf44
 chromosome 11 open reading frame 44
 99049
 0.08
chr14_23013027_23013178 0.11 AE000662.92
 Uncharacterized protein
 12432
 0.1
chr5_980906_981122 0.11 RP11-661C8.3
 Uncharacterized protein
 1534
 0.31
chr14_90097002_90097153 0.11 RP11-944C7.1
 Protein LOC100506792
 833
 0.53
chr12_6876888_6877289 0.11 MLF2
 myeloid leukemia factor 2
 447
 0.58
chr2_45429_45675 0.11 FAM110C
 family with sequence similarity 110, member C
 833
 0.76
chr15_32267489_32267710 0.11 ENSG00000206849
 .
 47093
 0.15
chr6_158034126_158034277 0.11 ZDHHC14
 zinc finger, DHHC-type containing 14
 20160
 0.25
chr19_35757937_35758321 0.11 USF2
 upstream transcription factor 2, c-fos interacting
 1752
 0.18
chr3_190580567_190581193 0.11 GMNC
 geminin coiled-coil domain containing
 476
 0.9
chr1_36180862_36181228 0.11 C1orf216
 chromosome 1 open reading frame 216
 4028
 0.18
chr7_97841044_97841241 0.11 BHLHA15
 basic helix-loop-helix family, member a15
 403
 0.86
chr3_29327052_29327571 0.11 RBMS3
 RNA binding motif, single stranded interacting protein 3
 4204
 0.26
chr14_96558753_96558904 0.11 C14orf132
 chromosome 14 open reading frame 132
 2232
 0.34
chr19_23185776_23185988 0.11 ZNF728
 zinc finger protein 728
 96
 0.98
chr12_50067178_50067329 0.11 FMNL3
 formin-like 3
 33750
 0.11
chr9_137437911_137438062 0.11 COL5A1
 collagen, type V, alpha 1
 95634
 0.07
chr18_77376610_77376761 0.11 CTDP1
 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
 63116
 0.12
chr9_130328652_130328977 0.11 FAM129B
 family with sequence similarity 129, member B
 2553
 0.26
chr9_44867829_44868127 0.11 RP11-160N1.10
407
 0.89
chr10_64323835_64324021 0.11 ZNF365
 zinc finger protein 365
 43721
 0.19
chrX_139847263_139847516 0.11 CDR1
 cerebellar degeneration-related protein 1, 34kDa
 19334
 0.22
chrX_64254778_64255285 0.11 ZC4H2
 zinc finger, C4H2 domain containing
 438
 0.91

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of BHLHE40

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1 0.3 GO:0021825 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.1 0.2 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.1 0.2 GO:0060676 ureteric bud formation(GO:0060676)
0.1 0.1 GO:1900120 regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.1 0.2 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0 0.1 GO:0060596 mammary placode formation(GO:0060596)
0.0 0.2 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.2 GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein(GO:0042532)
0.0 0.2 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.0 0.2 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.2 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.1 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0 0.1 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.1 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.0 0.1 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.1 GO:0034201 response to oleic acid(GO:0034201)
0.0 0.1 GO:0016081 synaptic vesicle docking(GO:0016081)
0.0 0.1 GO:0070141 response to UV-A(GO:0070141)
0.0 0.1 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.1 GO:0016115 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0 0.2 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.1 GO:0002887 negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.0 0.1 GO:0010040 response to iron(II) ion(GO:0010040)
0.0 0.1 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.0 0.1 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.1 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0 0.1 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.1 GO:0010661 positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0 0.1 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.0 0.3 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.0 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.1 GO:0060737 prostate gland morphogenetic growth(GO:0060737)
0.0 0.1 GO:0072268 pattern specification involved in metanephros development(GO:0072268)
0.0 0.1 GO:0043578 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.2 GO:0060644 mammary gland epithelial cell differentiation(GO:0060644)
0.0 0.1 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.0 0.1 GO:0072071 mesangial cell differentiation(GO:0072007) kidney interstitial fibroblast differentiation(GO:0072071) renal interstitial fibroblast development(GO:0072141) mesangial cell development(GO:0072143) pericyte cell differentiation(GO:1904238)
0.0 0.1 GO:0009649 entrainment of circadian clock(GO:0009649)
0.0 0.2 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.1 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.0 0.0 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.1 GO:0033015 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0 0.0 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.0 GO:0051280 negative regulation of ion transmembrane transporter activity(GO:0032413) negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0 0.1 GO:0072201 negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0 0.1 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0 0.1 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.1 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.1 GO:0006924 activation-induced cell death of T cells(GO:0006924)
0.0 0.1 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0009109 coenzyme catabolic process(GO:0009109)
0.0 0.0 GO:0071218 cellular response to misfolded protein(GO:0071218)
0.0 0.1 GO:0051503 adenine nucleotide transport(GO:0051503)
0.0 0.0 GO:0044413 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.0 GO:0031558 obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0 0.1 GO:0010561 negative regulation of glycoprotein biosynthetic process(GO:0010561)
0.0 0.0 GO:0010842 retina layer formation(GO:0010842)
0.0 0.1 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.0 0.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.1 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.2 GO:0042474 middle ear morphogenesis(GO:0042474)
0.0 0.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.2 GO:0018208 peptidyl-proline modification(GO:0018208)
0.0 0.0 GO:0010996 response to auditory stimulus(GO:0010996) auditory behavior(GO:0031223)
0.0 0.0 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 0.1 GO:0018126 protein hydroxylation(GO:0018126)
0.0 0.1 GO:0035437 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0 0.0 GO:0032060 bleb assembly(GO:0032060)
0.0 0.0 GO:0014820 tonic smooth muscle contraction(GO:0014820) artery smooth muscle contraction(GO:0014824)
0.0 0.0 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 0.0 GO:0072033 renal vesicle formation(GO:0072033)
0.0 0.0 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.1 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.0 0.0 GO:0060412 ventricular septum morphogenesis(GO:0060412)
0.0 0.0 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.0 GO:0040023 establishment of nucleus localization(GO:0040023)
0.0 0.1 GO:0031290 retinal ganglion cell axon guidance(GO:0031290)
0.0 0.1 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.0 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.0 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.0 GO:0045077 negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0 0.2 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.0 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.0 GO:0002072 optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0 0.0 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.0 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.0 GO:0008049 male courtship behavior(GO:0008049)
0.0 0.1 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.0 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.0 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.0 GO:0021955 central nervous system neuron axonogenesis(GO:0021955)
0.0 0.0 GO:0014826 vein smooth muscle contraction(GO:0014826)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0043259 laminin-10 complex(GO:0043259)
0.0 0.1 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.2 GO:0005593 FACIT collagen trimer(GO:0005593)
0.0 0.2 GO:0071778 obsolete WINAC complex(GO:0071778)
0.0 0.2 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0001527 microfibril(GO:0001527)
0.0 0.1 GO:0005606 laminin-1 complex(GO:0005606)
0.0 0.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.1 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.0 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.3 GO:0000299 obsolete integral to membrane of membrane fraction(GO:0000299)
0.0 0.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742) outer mitochondrial membrane protein complex(GO:0098799)
0.0 0.0 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.1 GO:0031512 motile primary cilium(GO:0031512)
0.0 0.0 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:0005883 neurofilament(GO:0005883)
0.0 0.1 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.0 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.3 GO:0042645 mitochondrial nucleoid(GO:0042645)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005113 patched binding(GO:0005113)
0.1 0.3 GO:0048495 Roundabout binding(GO:0048495)
0.1 0.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.3 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.2 GO:0055106 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.1 GO:0070548 L-glutamine aminotransferase activity(GO:0070548)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 0.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.2 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.1 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.2 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 0.1 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.2 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.1 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0015288 porin activity(GO:0015288)
0.0 0.1 GO:0042156 obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0 0.1 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.0 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.1 GO:0005497 androgen binding(GO:0005497)
0.0 0.2 GO:0005112 Notch binding(GO:0005112)
0.0 0.0 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.2 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.1 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.1 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.1 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.2 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.0 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.0 0.1 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.0 GO:0045159 myosin II binding(GO:0045159)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)
0.0 0.0 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.0 0.1 GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0 0.1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0 0.2 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.0 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.0 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.0 GO:0032356 single guanine insertion binding(GO:0032142) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357)
0.0 0.1 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 0.0 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.1 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.0 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.1 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.1 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.0 GO:0001098 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.0 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0 0.0 GO:0016151 nickel cation binding(GO:0016151)
0.0 0.0 GO:0042808 obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0 0.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.4 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.5 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.6 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.7 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.1 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.4 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.2 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.4 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.0 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.2 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.3 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.3 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.1 REACTOME PI3K EVENTS IN ERBB2 SIGNALING Genes involved in PI3K events in ERBB2 signaling
0.0 0.2 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.1 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.1 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.2 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.1 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.2 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.0 0.0 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline