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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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Results for BRCA1

Z-value: 1.45

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Transcription factors associated with BRCA1

Gene Symbol	Gene ID	Gene Info
BRCA1 Ensembl NCBI GeneCards UniProt	ENSG00000012048.15	BRCA1 DNA repair associated

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr17_41231951_41232102	BRCA1	11815	0.121016	-0.40	2.9e-01	Click!
chr17_41277630_41278242	BRCA1	436	0.765121	0.36	3.4e-01	Click!
chr17_41231201_41231352	BRCA1	12565	0.119476	-0.35	3.6e-01	Click!
chr17_41276544_41276767	BRCA1	523	0.706128	0.32	4.0e-01	Click!
chr17_41276997_41277380	BRCA1	129	0.944876	0.28	4.7e-01	Click!

Activity of the BRCA1 motif across conditions

Conditions sorted by the z-value of the BRCA1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr5_124083658_124084316	0.44	ZNF608	zinc finger protein 608	513	0.71
chr12_32121705_32121856	0.39	KIAA1551	KIAA1551	6357	0.25
chr3_46140245_46140452	0.32	CCR3	chemokine (C-C motif) receptor 3	64748	0.1
chr3_10334877_10335066	0.32	GHRL	ghrelin/obestatin prepropeptide	340	0.8
chr15_50405090_50405480	0.29	ATP8B4	ATPase, class I, type 8B, member 4	1416	0.49
chr18_25616723_25616874	0.29	CDH2	cadherin 2, type 1, N-cadherin (neuronal)	249	0.96
chr5_53966332_53966483	0.28	SNX18	sorting nexin 18	152814	0.04
chr11_35067009_35067160	0.27	PDHX	pyruvate dehydrogenase complex, component X	67753	0.09
chr16_72351661_72351812	0.27	ENSG00000207514	.	58867	0.14
chr8_142288307_142288672	0.26	RP11-10J21.3	Uncharacterized protein	23825	0.12
chr10_26769119_26769296	0.26	ENSG00000199733	.	29311	0.21
chr6_159464766_159465080	0.25	TAGAP	T-cell activation RhoGTPase activating protein	1127	0.51
chr3_171857071_171857222	0.25	FNDC3B	fibronectin type III domain containing 3B	12382	0.27
chr14_75530854_75531045	0.25	ZC2HC1C	zinc finger, C2HC-type containing 1C	76	0.66
chr18_60587162_60587313	0.25	PHLPP1	PH domain and leucine rich repeat protein phosphatase 1	16854	0.24
chr19_47732635_47732786	0.24	BBC3	BCL2 binding component 3	1741	0.26
chr1_62902842_62903691	0.24	USP1	ubiquitin specific peptidase 1	940	0.68
chr7_38385599_38385750	0.24	AMPH	amphiphysin	117039	0.06
chr1_244012088_244013269	0.24	AKT3	v-akt murine thymoma viral oncogene homolog 3	752	0.75
chr1_239883177_239883989	0.24	CHRM3	cholinergic receptor, muscarinic 3	740	0.59
chr16_2480390_2480541	0.23	CCNF	cyclin F	1070	0.31
chr2_68592484_68592752	0.23	AC015969.3		98	0.77
chr4_2873840_2873991	0.23	ADD1	adducin 1 (alpha)	3708	0.23
chr1_161531648_161531799	0.23	RP11-5K23.5		4855	0.14
chr13_46747717_46747935	0.23	ENSG00000240767	.	3943	0.19
chr6_41254142_41254293	0.23	TREM1	triggering receptor expressed on myeloid cells 1	186	0.93
chr6_137628506_137628657	0.23	IFNGR1	interferon gamma receptor 1	87995	0.09
chr8_82053204_82053355	0.23	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	28976	0.23
chr13_113238170_113238506	0.23	TUBGCP3	tubulin, gamma complex associated protein 3	4101	0.29
chr10_112263856_112264007	0.22	DUSP5	dual specificity phosphatase 5	6335	0.2
chr10_98460336_98460510	0.22	PIK3AP1	phosphoinositide-3-kinase adaptor protein 1	19848	0.19
chr9_134502851_134503002	0.22	RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	1591	0.45
chr16_89831548_89831767	0.22	FANCA	Fanconi anemia, complementation group A	20187	0.11
chrX_12924806_12924957	0.22	TLR8	toll-like receptor 8	123	0.95
chr5_169307394_169307545	0.22	FAM196B	family with sequence similarity 196, member B	100275	0.07
chr10_126600015_126600236	0.22	RP11-298J20.4		5587	0.2
chr4_37749764_37749915	0.22	ENSG00000207075	.	48215	0.15
chr17_80198544_80198695	0.22	SLC16A3	solute carrier family 16 (monocarboxylate transporter), member 3	3573	0.13
chr15_75471507_75471789	0.21	C15orf39	chromosome 15 open reading frame 39	16336	0.13
chr2_149302935_149303086	0.21	MBD5	methyl-CpG binding domain protein 5	76716	0.11
chr6_13141465_13141616	0.21	PHACTR1	phosphatase and actin regulator 1	41211	0.18
chr11_36439016_36439167	0.21	RP11-219O3.2		8581	0.19
chr4_107629880_107630031	0.21	ENSG00000222333	.	293013	0.01
chr6_15267933_15268084	0.21	JARID2	jumonji, AT rich interactive domain 2	18865	0.18
chr4_2814595_2815029	0.21	SH3BP2	SH3-domain binding protein 2	781	0.66
chr11_48031424_48031575	0.21	AC103828.1		5908	0.23
chrX_13103844_13104411	0.21	FAM9C	family with sequence similarity 9, member C	41326	0.19
chr5_131761596_131761780	0.21	AC116366.5		458	0.75
chr12_51721791_51721942	0.21	BIN2	bridging integrator 2	3414	0.2
chr17_47077080_47077320	0.21	IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	2092	0.16
chr9_91791007_91791172	0.21	SHC3	SHC (Src homology 2 domain containing) transforming protein 3	2593	0.36
chr13_30946126_30946576	0.21	KATNAL1	katanin p60 subunit A-like 1	64730	0.12
chr4_56812643_56812942	0.20	CEP135	centrosomal protein 135kDa	2245	0.32
chr14_75754220_75754694	0.20	FOS	FBJ murine osteosarcoma viral oncogene homolog	7561	0.17
chr19_54374556_54374717	0.20	MYADM	myeloid-associated differentiation marker	1617	0.15
chr19_49839028_49839359	0.20	CD37	CD37 molecule	472	0.63
chr8_81960196_81960347	0.20	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	64032	0.14
chr12_94517592_94517768	0.20	PLXNC1	plexin C1	24819	0.2
chr6_21667246_21667439	0.20	SOX4	SRY (sex determining region Y)-box 4	73271	0.14
chr15_75336418_75336696	0.20	PPCDC	phosphopantothenoylcysteine decarboxylase	941	0.52
chr6_20417053_20417224	0.20	ENSG00000240869	.	4980	0.16
chr19_2083107_2083981	0.20	MOB3A	MOB kinase activator 3A	1847	0.21
chr20_47896296_47896853	0.20	ENSG00000222365	.	282	0.64
chr3_4516286_4516499	0.20	SUMF1	sulfatase modifying factor 1	7427	0.21
chr11_33914773_33914937	0.20	LMO2	LIM domain only 2 (rhombotin-like 1)	1019	0.57
chr9_35730331_35730482	0.20	CREB3	cAMP responsive element binding protein 3	1926	0.14
chr12_12493032_12493183	0.20	MANSC1	MANSC domain containing 1	1499	0.37
chr16_17087479_17087630	0.20	CTD-2576D5.4		140807	0.05
chr8_81210161_81210312	0.20	ENSG00000206649	.	19068	0.21
chr5_5147674_5147825	0.20	ADAMTS16	ADAM metallopeptidase with thrombospondin type 1 motif, 16	7306	0.18
chr6_159482531_159482682	0.20	TAGAP	T-cell activation RhoGTPase activating protein	16422	0.19
chr6_159465648_159465970	0.19	TAGAP	T-cell activation RhoGTPase activating protein	241	0.93
chr8_37731641_37731792	0.19	RAB11FIP1	RAB11 family interacting protein 1 (class I)	3919	0.18
chr1_169555058_169555307	0.19	F5	coagulation factor V (proaccelerin, labile factor)	537	0.81
chr15_51850784_51850935	0.19	ENSG00000263437	.	51104	0.12
chr13_99037141_99037432	0.19	FARP1	FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)	7211	0.22
chr4_48214424_48214688	0.19	TEC	tec protein tyrosine kinase	57325	0.11
chr3_128789857_128790008	0.19	ENSG00000252435	.	2207	0.2
chr1_9713633_9713784	0.19	C1orf200	chromosome 1 open reading frame 200	936	0.49
chr6_37142538_37142689	0.19	PIM1	pim-1 oncogene	4634	0.21
chr3_157816045_157816297	0.19	SHOX2	short stature homeobox 2	6912	0.25
chr2_240302618_240303103	0.19	HDAC4	histone deacetylase 4	19783	0.17
chr2_16083994_16084145	0.19	MYCNOS	MYCN opposite strand	1698	0.32
chr12_8693614_8693765	0.19	CLEC4E	C-type lectin domain family 4, member E	130	0.95
chr9_123639853_123640396	0.18	PHF19	PHD finger protein 19	518	0.78
chr10_73398214_73398397	0.18	CDH23	cadherin-related 23	7368	0.27
chr12_323214_323365	0.18	SLC6A12	solute carrier family 6 (neurotransmitter transporter), member 12	3	0.97
chr22_18260050_18260218	0.18	BID	BH3 interacting domain death agonist	2703	0.26
chr20_52370901_52371111	0.18	ENSG00000238468	.	85709	0.09
chr17_33379941_33380092	0.18	ENSG00000238858	.	1497	0.28
chr14_51706549_51708116	0.18	TMX1	thioredoxin-related transmembrane protein 1	446	0.81
chr9_82316523_82316674	0.18	TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	3100	0.42
chr19_10382297_10382473	0.18	ICAM1	intercellular adhesion molecule 1	589	0.49
chr15_100052430_100052643	0.18	AC015660.1	HCG1993240; Serologically defined breast cancer antigen NY-BR-40; Uncharacterized protein	13958	0.21
chr4_190487582_190487733	0.18	ENSG00000202215	.	143211	0.05
chr19_16256329_16256493	0.18	HSH2D	hematopoietic SH2 domain containing	1865	0.23
chr1_161186326_161186719	0.18	FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	1435	0.17
chr3_169996000_169996151	0.18	ENSG00000200118	.	33505	0.16
chr10_90595544_90595695	0.18	ANKRD22	ankyrin repeat domain 22	15956	0.16
chr16_31478688_31478839	0.18	TGFB1I1	transforming growth factor beta 1 induced transcript 1	4143	0.1
chrX_1368129_1368460	0.18	CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	19399	0.11
chr1_27438843_27438994	0.18	SLC9A1	solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1	42055	0.13
chr10_104411925_104412076	0.18	TRIM8	tripartite motif containing 8	7356	0.18
chr4_100777669_100777820	0.18	LAMTOR3	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3	37789	0.15
chr19_16439528_16440069	0.18	KLF2	Kruppel-like factor 2	4147	0.17
chr15_92404681_92404832	0.18	SLCO3A1	solute carrier organic anion transporter family, member 3A1	7405	0.27
chr2_74780571_74780754	0.18	LOXL3	lysyl oxidase-like 3	400	0.5
chr8_3142398_3142549	0.18	RP11-279L11.1		90275	0.1
chr6_51167991_51168154	0.18	ENSG00000212532	.	161416	0.04
chr16_21637725_21637968	0.18	CTB-31N19.3		217	0.89
chr12_124941723_124942278	0.18	NCOR2	nuclear receptor corepressor 2	26315	0.25
chr4_184949529_184949975	0.18	STOX2	storkhead box 2	27274	0.21
chr15_70851492_70851719	0.18	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	143015	0.05
chr12_133021289_133021651	0.18	MUC8	mucin 8	29256	0.17
chr11_33889968_33890119	0.17	LMO2	LIM domain only 2 (rhombotin-like 1)	1319	0.46
chr20_4793017_4793168	0.17	RASSF2	Ras association (RalGDS/AF-6) domain family member 2	2677	0.29
chr1_235114742_235115156	0.17	ENSG00000239690	.	75016	0.11
chr6_109700289_109700440	0.17	CD164	CD164 molecule, sialomucin	2539	0.21
chr2_128242713_128242946	0.17	ENSG00000202429	.	13019	0.14
chr8_134086469_134086645	0.17	SLA	Src-like-adaptor	13954	0.23
chr10_81115927_81116078	0.17	PPIF	peptidylprolyl isomerase F	8588	0.21
chr8_27185487_27185714	0.17	PTK2B	protein tyrosine kinase 2 beta	1260	0.49
chr12_4937651_4937802	0.17	RP3-377H17.2		10395	0.2
chr15_76630019_76630254	0.17	ISL2	ISL LIM homeobox 2	1071	0.52
chr7_37391096_37391247	0.17	ENSG00000222869	.	424	0.83
chr13_41137300_41137451	0.17	AL133318.1	Uncharacterized protein	26052	0.23
chr7_134845221_134845461	0.17	RP11-134L10.1		7814	0.14
chr7_105896688_105896839	0.17	NAMPT	nicotinamide phosphoribosyltransferase	28604	0.18
chr12_110937202_110937419	0.17	VPS29	vacuolar protein sorting 29 homolog (S. cerevisiae)	41	0.96
chr6_9646598_9646749	0.17	OFCC1	orofacial cleft 1 candidate 1	286827	0.01
chr17_72837017_72837168	0.17	GRIN2C	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	18906	0.11
chr10_11211784_11212275	0.17	RP3-323N1.2		1310	0.48
chr1_9515397_9515548	0.17	ENSG00000252956	.	17635	0.22
chr1_101416238_101416389	0.17	SLC30A7	solute carrier family 30 (zinc transporter), member 7	11071	0.16
chr17_78748885_78749036	0.17	RP11-28G8.1		30472	0.2
chr15_90357053_90357234	0.17	ANPEP	alanyl (membrane) aminopeptidase	951	0.46
chr10_12261405_12261556	0.17	CDC123	cell division cycle 123	11467	0.14
chr22_31631160_31631361	0.17	ENSG00000202019	.	5102	0.12
chr5_42993270_42993458	0.17	CTD-2035E11.3		25167	0.15
chr4_908798_909074	0.17	GAK	cyclin G associated kinase	587	0.7
chr6_90914216_90914367	0.17	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2	92170	0.08
chr11_121460609_121460760	0.17	SORL1	sortilin-related receptor, L(DLR class) A repeats containing	444	0.91
chr4_156597025_156597176	0.17	GUCY1A3	guanylate cyclase 1, soluble, alpha 3	8285	0.26
chr17_53343669_53343820	0.17	HLF	hepatic leukemia factor	161	0.97
chr2_103038781_103038932	0.17	IL18RAP	interleukin 18 receptor accessory protein	2710	0.2
chr16_29611347_29611550	0.17	ENSG00000266758	.	862	0.54
chr17_76117639_76118201	0.17	TMC6	transmembrane channel-like 6	909	0.44
chr15_91955039_91955190	0.17	SV2B	synaptic vesicle glycoprotein 2B	186014	0.03
chr2_106811046_106811532	0.17	UXS1	UDP-glucuronate decarboxylase 1	494	0.84
chr15_49087139_49087290	0.17	RP11-485O10.2		11827	0.17
chr7_38381792_38381992	0.17	AMPH	amphiphysin	120821	0.06
chr12_89551632_89551783	0.17	ENSG00000238302	.	124355	0.06
chr4_87930714_87930865	0.16	AFF1	AF4/FMR2 family, member 1	2368	0.4
chr15_32753837_32754108	0.16	GOLGA8O	golgin A8 family, member O	6137	0.12
chr10_65015927_65016153	0.16	JMJD1C	jumonji domain containing 1C	12786	0.27
chr6_10532255_10532677	0.16	GCNT2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	3877	0.23
chr20_61434177_61434328	0.16	OGFR	opioid growth factor receptor	1935	0.2
chr8_24154877_24155028	0.16	ADAM28	ADAM metallopeptidase domain 28	3328	0.33
chr10_101943124_101943275	0.16	ERLIN1	ER lipid raft associated 1	2587	0.2
chr4_153584584_153584901	0.16	RP11-768B22.2		2778	0.3
chr15_30837914_30838184	0.16	GOLGA8Q	golgin A8 family, member Q	6134	0.1
chr2_45992463_45992614	0.16	U51244.2		89923	0.09
chr14_23030469_23030620	0.16	AE000662.93		4588	0.12
chr1_156316410_156316561	0.16	TSACC	TSSK6 activating co-chaperone	7792	0.11
chr8_108317021_108317172	0.16	ANGPT1	angiopoietin 1	31654	0.22
chr2_10260619_10261062	0.16	RRM2	ribonucleotide reductase M2	1615	0.27
chr19_52034414_52034565	0.16	SIGLEC6	sialic acid binding Ig-like lectin 6	482	0.69
chr12_11951284_11951435	0.16	ETV6	ets variant 6	45924	0.19
chr1_181474291_181474442	0.16	CACNA1E	calcium channel, voltage-dependent, R type, alpha 1E subunit	21485	0.28
chr13_41556163_41556400	0.16	ELF1	E74-like factor 1 (ets domain transcription factor)	137	0.96
chr2_46496822_46496973	0.16	EPAS1	endothelial PAS domain protein 1	26850	0.23
chr5_72143802_72143953	0.16	TNPO1	transportin 1	134	0.96
chr11_6399898_6400064	0.16	SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	11674	0.14
chr4_185276257_185276428	0.16	IRF2	interferon regulatory factor 2	63402	0.1
chr17_56406568_56406782	0.16	BZRAP1-AS1	BZRAP1 antisense RNA 1	291	0.64
chr1_26159345_26159496	0.16	RP1-317E23.7		795	0.43
chr13_20795977_20796128	0.16	GJB6	gap junction protein, beta 6, 30kDa	9065	0.2
chr7_38295984_38296251	0.16	STARD3NL	STARD3 N-terminal like	78120	0.12
chr5_116293290_116293441	0.16	SEMA6A	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	382735	0.01
chr11_47950032_47950284	0.16	PTPRJ	protein tyrosine phosphatase, receptor type, J	51955	0.12
chr10_98406541_98406692	0.16	PIK3AP1	phosphoinositide-3-kinase adaptor protein 1	13618	0.19
chr17_2717574_2718059	0.16	RAP1GAP2	RAP1 GTPase activating protein 2	18040	0.17
chr18_52985449_52985614	0.16	TCF4	transcription factor 4	3686	0.35
chr1_22416925_22417087	0.16	CDC42-IT1	CDC42 intronic transcript 1 (non-protein coding)	31316	0.12
chr2_158298330_158298802	0.16	ENSG00000216054	.	504	0.79
chr12_133347795_133347946	0.16	ANKLE2	ankyrin repeat and LEM domain containing 2	9396	0.15
chr8_39797291_39797650	0.16	IDO2	indoleamine 2,3-dioxygenase 2	4996	0.18
chr2_61685095_61685246	0.16	USP34	ubiquitin specific peptidase 34	12734	0.18
chr11_67981482_67982050	0.16	SUV420H1	suppressor of variegation 4-20 homolog 1 (Drosophila)	471	0.83
chr7_8054646_8054797	0.16	AC006042.7		45187	0.13
chr10_115856349_115856500	0.16	ENSG00000253066	.	14749	0.19
chr4_181931488_181931639	0.16	ENSG00000251742	.	824698	0.0
chr1_8499333_8499484	0.16	RP5-1115A15.1		13710	0.19
chr17_38279440_38280347	0.16	MSL1	male-specific lethal 1 homolog (Drosophila)	937	0.43
chr7_37741442_37741593	0.16	GPR141	G protein-coupled receptor 141	18042	0.22
chr1_39670452_39671908	0.16	MACF1	microtubule-actin crosslinking factor 1	757	0.48
chr10_12408131_12408282	0.15	CAMK1D	calcium/calmodulin-dependent protein kinase ID	16474	0.18
chrX_30673136_30673477	0.15	GK	glycerol kinase	1651	0.37
chr8_26439826_26439977	0.15	DPYSL2	dihydropyrimidinase-like 2	3980	0.32
chr9_81879361_81879950	0.15	TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	307033	0.01

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of BRCA1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0060398	regulation of growth hormone receptor signaling pathway(GO:0060398)
0.1	0.2	GO:0030210	heparin biosynthetic process(GO:0030210)
0.1	0.3	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.1	0.1	GO:0052167	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308)
0.1	0.1	GO:0030223	neutrophil differentiation(GO:0030223)
0.1	0.4	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.1	0.2	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.1	0.1	GO:0032776	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.1	0.2	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.1	0.2	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.1	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.4	GO:0050858	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.1	GO:0050689	negative regulation of defense response to virus by host(GO:0050689)
0.0	0.2	GO:0031061	negative regulation of histone methylation(GO:0031061)
0.0	0.3	GO:0031641	regulation of myelination(GO:0031641)
0.0	0.1	GO:0030422	production of siRNA involved in RNA interference(GO:0030422)
0.0	0.1	GO:0018243	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0	0.3	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.1	GO:0032632	interleukin-3 production(GO:0032632)
0.0	0.1	GO:0045759	negative regulation of action potential(GO:0045759)
0.0	0.2	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.2	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.0	GO:0002475	antigen processing and presentation via MHC class Ib(GO:0002475)
0.0	0.3	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.1	GO:0048003	antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.1	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.4	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.1	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.2	GO:0046469	platelet activating factor metabolic process(GO:0046469)
0.0	0.1	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.1	GO:0046813	receptor-mediated virion attachment to host cell(GO:0046813)
0.0	0.2	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.1	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.0	0.1	GO:0015705	iodide transport(GO:0015705)
0.0	0.1	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.2	GO:0009186	deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.0	0.1	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0	0.5	GO:0016601	Rac protein signal transduction(GO:0016601)
0.0	0.2	GO:0071470	cellular response to osmotic stress(GO:0071470)
0.0	0.1	GO:0016265	obsolete death(GO:0016265)
0.0	0.0	GO:1903170	negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0	0.1	GO:0046015	carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015)
0.0	0.1	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.0	GO:0046007	negative regulation of activated T cell proliferation(GO:0046007)
0.0	0.1	GO:0030581	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.0	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0	0.1	GO:0070071	proton-transporting two-sector ATPase complex assembly(GO:0070071)
0.0	0.2	GO:0014049	positive regulation of glutamate secretion(GO:0014049)
0.0	0.1	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.0	0.1	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.1	GO:0016199	axon midline choice point recognition(GO:0016199)
0.0	0.1	GO:0007100	mitotic centrosome separation(GO:0007100)
0.0	0.2	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.0	0.1	GO:0006565	L-serine catabolic process(GO:0006565)
0.0	0.1	GO:0010988	regulation of low-density lipoprotein particle clearance(GO:0010988)
0.0	0.1	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.2	GO:0019682	pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.0	0.1	GO:0014009	glial cell proliferation(GO:0014009)
0.0	0.1	GO:0001779	natural killer cell differentiation(GO:0001779)
0.0	0.1	GO:0048261	negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0	0.1	GO:0006528	asparagine metabolic process(GO:0006528)
0.0	0.1	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.1	GO:0042494	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.1	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.0	0.1	GO:0050687	negative regulation of defense response to virus(GO:0050687)
0.0	0.0	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.1	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.0	0.1	GO:0032876	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.1	GO:0071545	inositol phosphate catabolic process(GO:0071545)
0.0	0.1	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.0	0.1	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.1	GO:0051532	NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0	0.1	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.0	0.2	GO:0010510	acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0	0.1	GO:0045056	transcytosis(GO:0045056)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.0	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0	0.1	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.2	GO:0042273	ribosomal large subunit biogenesis(GO:0042273)
0.0	0.0	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.1	GO:0008608	attachment of spindle microtubules to kinetochore(GO:0008608)
0.0	0.0	GO:0009191	nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.0	0.1	GO:0030174	regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0	0.0	GO:0042501	serine phosphorylation of STAT protein(GO:0042501)
0.0	0.0	GO:0030952	establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.0	0.1	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.1	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0	0.1	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.1	GO:0090400	stress-induced premature senescence(GO:0090400)
0.0	0.1	GO:0002327	immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.0	0.1	GO:0050685	positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.0	GO:0051299	centrosome separation(GO:0051299)
0.0	0.0	GO:0060586	multicellular organismal iron ion homeostasis(GO:0060586)
0.0	0.1	GO:1903670	regulation of cell migration involved in sprouting angiogenesis(GO:0090049) regulation of sprouting angiogenesis(GO:1903670)
0.0	0.2	GO:0071044	histone mRNA catabolic process(GO:0071044)
0.0	0.1	GO:0042661	regulation of mesodermal cell fate specification(GO:0042661) regulation of mesoderm development(GO:2000380)
0.0	0.0	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.0	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.0	0.1	GO:0000281	mitotic cytokinesis(GO:0000281)
0.0	0.1	GO:0050667	homocysteine metabolic process(GO:0050667)
0.0	0.1	GO:0019255	glucose 1-phosphate metabolic process(GO:0019255)
0.0	0.1	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0050901	leukocyte tethering or rolling(GO:0050901) leukocyte adhesion to vascular endothelial cell(GO:0061756)
0.0	0.1	GO:1901503	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0048488	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.0	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:0046606	negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606)
0.0	0.1	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.0	0.0	GO:0022417	protein maturation by protein folding(GO:0022417)
0.0	0.2	GO:0015669	gas transport(GO:0015669)
0.0	0.0	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.1	GO:0072600	protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0	0.1	GO:0050930	induction of positive chemotaxis(GO:0050930)
0.0	0.0	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.0	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.3	GO:0006611	protein export from nucleus(GO:0006611)
0.0	0.0	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.0	GO:0090085	regulation of protein deubiquitination(GO:0090085)
0.0	0.2	GO:0043388	positive regulation of DNA binding(GO:0043388)
0.0	0.2	GO:0045806	negative regulation of endocytosis(GO:0045806)
0.0	0.1	GO:0016264	gap junction assembly(GO:0016264)
0.0	0.0	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.0	0.0	GO:0071637	monocyte chemotactic protein-1 production(GO:0071605) regulation of monocyte chemotactic protein-1 production(GO:0071637)
0.0	0.1	GO:0033523	histone H2B ubiquitination(GO:0033523)
0.0	0.0	GO:0009405	pathogenesis(GO:0009405)
0.0	0.1	GO:0016322	neuron remodeling(GO:0016322)
0.0	0.0	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.0	GO:0072311	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.1	GO:0002031	G-protein coupled receptor internalization(GO:0002031)
0.0	0.1	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.1	GO:0006983	ER overload response(GO:0006983)
0.0	0.0	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0	0.0	GO:0007343	egg activation(GO:0007343)
0.0	0.0	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0	0.1	GO:0051319	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.6	GO:0006888	ER to Golgi vesicle-mediated transport(GO:0006888)
0.0	0.1	GO:0060023	soft palate development(GO:0060023)
0.0	0.0	GO:0048840	otolith development(GO:0048840)
0.0	0.0	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0	0.2	GO:0006906	vesicle fusion(GO:0006906)
0.0	0.1	GO:0032515	negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0	0.0	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.0	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0	0.1	GO:0016556	mRNA modification(GO:0016556)
0.0	0.1	GO:0046477	glycosylceramide catabolic process(GO:0046477)
0.0	0.0	GO:0043306	positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of leukocyte degranulation(GO:0043302) positive regulation of mast cell degranulation(GO:0043306)
0.0	0.0	GO:0043620	regulation of DNA-templated transcription in response to stress(GO:0043620)
0.0	0.0	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.1	GO:0034505	tooth mineralization(GO:0034505)
0.0	0.0	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.0	GO:0002540	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.1	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.1	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.2	GO:0050853	B cell receptor signaling pathway(GO:0050853)
0.0	0.0	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.1	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0	0.1	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
0.0	0.0	GO:0090398	cellular senescence(GO:0090398)
0.0	0.1	GO:0030321	transepithelial chloride transport(GO:0030321)
0.0	0.0	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.0	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.0	GO:0031223	auditory behavior(GO:0031223)
0.0	0.0	GO:0002740	negative regulation of cytokine secretion involved in immune response(GO:0002740)
0.0	0.1	GO:0030224	monocyte differentiation(GO:0030224)
0.0	0.0	GO:0007549	dosage compensation(GO:0007549)
0.0	0.0	GO:0044240	multicellular organism lipid catabolic process(GO:0044240)
0.0	0.2	GO:0006783	heme biosynthetic process(GO:0006783)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.0	GO:2000649	regulation of sodium:proton antiporter activity(GO:0032415) regulation of sodium ion transmembrane transport(GO:1902305) regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0	0.0	GO:0046174	polyol catabolic process(GO:0046174)
0.0	0.0	GO:0015825	L-serine transport(GO:0015825)
0.0	0.1	GO:0045161	neuronal ion channel clustering(GO:0045161)
0.0	0.1	GO:0006376	mRNA splice site selection(GO:0006376)
0.0	0.3	GO:0033209	tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0	0.3	GO:0006099	tricarboxylic acid cycle(GO:0006099)
0.0	0.1	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.0	0.1	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.0	GO:0007144	female meiosis I(GO:0007144)
0.0	0.0	GO:0030186	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.0	GO:0031657	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0	0.1	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.2	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
0.0	0.0	GO:0043457	regulation of cellular respiration(GO:0043457)
0.0	0.0	GO:0006678	glucosylceramide metabolic process(GO:0006678)
0.0	0.0	GO:0019388	galactose catabolic process(GO:0019388)
0.0	0.2	GO:0006891	intra-Golgi vesicle-mediated transport(GO:0006891)
0.0	0.0	GO:0046185	aldehyde catabolic process(GO:0046185)
0.0	0.0	GO:0031848	protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247)
0.0	0.1	GO:0021799	cerebral cortex radially oriented cell migration(GO:0021799)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.0	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0	0.0	GO:0051775	response to redox state(GO:0051775)
0.0	0.0	GO:2000189	regulation of cholesterol homeostasis(GO:2000188) positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.0	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.1	GO:0006265	DNA topological change(GO:0006265)
0.0	0.0	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.0	0.1	GO:0016574	histone ubiquitination(GO:0016574)
0.0	0.1	GO:0015851	nucleobase transport(GO:0015851)
0.0	0.1	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.0	GO:0051409	response to nitrosative stress(GO:0051409)
0.0	0.1	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.0	GO:0051934	dopamine uptake involved in synaptic transmission(GO:0051583) catecholamine uptake involved in synaptic transmission(GO:0051934) catecholamine uptake(GO:0090493) dopamine uptake(GO:0090494)
0.0	0.1	GO:0045793	positive regulation of cell size(GO:0045793)
0.0	0.1	GO:0006024	glycosaminoglycan biosynthetic process(GO:0006024)
0.0	0.1	GO:0007035	vacuolar acidification(GO:0007035)
0.0	0.0	GO:0070584	mitochondrion morphogenesis(GO:0070584)
0.0	0.0	GO:0033505	floor plate morphogenesis(GO:0033505)
0.0	0.0	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.1	GO:1902579	multi-organism transport(GO:0044766) transport of virus(GO:0046794) intracellular transport of virus(GO:0075733) multi-organism localization(GO:1902579) multi-organism intracellular transport(GO:1902583)
0.0	0.1	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.2	GO:0000060	protein import into nucleus, translocation(GO:0000060)
0.0	0.0	GO:0034983	peptidyl-lysine deacetylation(GO:0034983)
0.0	0.1	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0	0.0	GO:0050849	negative regulation of calcium-mediated signaling(GO:0050849)
0.0	0.1	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.0	0.1	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.0	0.0	GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.1	GO:0042987	amyloid precursor protein catabolic process(GO:0042987)
0.0	0.0	GO:0016572	histone phosphorylation(GO:0016572)
0.0	0.0	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0	0.0	GO:0006999	nuclear pore organization(GO:0006999)
0.0	0.0	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.0	GO:0045329	amino-acid betaine biosynthetic process(GO:0006578) carnitine biosynthetic process(GO:0045329)
0.0	0.1	GO:0043029	T cell homeostasis(GO:0043029)
0.0	0.0	GO:0010940	positive regulation of necrotic cell death(GO:0010940)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.1	GO:0009820	alkaloid metabolic process(GO:0009820)
0.0	0.0	GO:2000542	negative regulation of gastrulation(GO:2000542)
0.0	0.1	GO:0006072	glycerol-3-phosphate metabolic process(GO:0006072)
0.0	0.0	GO:0046886	positive regulation of hormone metabolic process(GO:0032352) positive regulation of hormone biosynthetic process(GO:0046886)
0.0	0.4	GO:0006695	cholesterol biosynthetic process(GO:0006695)
0.0	0.0	GO:0071360	cellular response to exogenous dsRNA(GO:0071360)
0.0	0.1	GO:0045947	negative regulation of translational initiation(GO:0045947)
0.0	0.1	GO:0048873	homeostasis of number of cells within a tissue(GO:0048873)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0001940	male pronucleus(GO:0001940)
0.0	0.2	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.1	GO:0030904	retromer complex(GO:0030904)
0.0	0.1	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.1	GO:0042582	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	0.1	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	0.2	GO:0098984	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	0.2	GO:0005916	fascia adherens(GO:0005916)
0.0	0.1	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.3	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0	0.1	GO:0000791	euchromatin(GO:0000791)
0.0	0.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.1	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.0	GO:0070552	BRISC complex(GO:0070552)
0.0	0.1	GO:0005682	U5 snRNP(GO:0005682)
0.0	0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.1	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.3	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.1	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	0.1	GO:0005638	lamin filament(GO:0005638)
0.0	0.1	GO:0001740	Barr body(GO:0001740)
0.0	0.2	GO:0000780	condensed nuclear chromosome, centromeric region(GO:0000780)
0.0	0.1	GO:0031095	platelet dense tubular network membrane(GO:0031095)
0.0	0.2	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0005869	dynactin complex(GO:0005869)
0.0	0.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.1	GO:0031229	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.0	GO:0001939	female pronucleus(GO:0001939)
0.0	0.2	GO:0001772	immunological synapse(GO:0001772)
0.0	0.1	GO:0031080	nuclear pore outer ring(GO:0031080)
0.0	0.1	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.1	GO:0042588	zymogen granule(GO:0042588)
0.0	0.1	GO:0005666	DNA-directed RNA polymerase III complex(GO:0005666)
0.0	0.1	GO:0042598	obsolete vesicular fraction(GO:0042598)
0.0	0.0	GO:0042629	mast cell granule(GO:0042629)
0.0	0.4	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0	0.1	GO:0000808	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	0.1	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.0	0.0	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.1	GO:0005675	holo TFIIH complex(GO:0005675)
0.0	0.2	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.0	0.1	GO:0031105	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.1	GO:0033011	perinuclear theca(GO:0033011)
0.0	0.0	GO:0005652	nuclear lamina(GO:0005652)
0.0	0.1	GO:0016272	prefoldin complex(GO:0016272)
0.0	0.1	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.1	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.0	GO:0005827	polar microtubule(GO:0005827)
0.0	0.0	GO:0072487	MSL complex(GO:0072487)
0.0	0.0	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.1	GO:0031304	intrinsic component of mitochondrial inner membrane(GO:0031304)
0.0	0.0	GO:0051233	spindle midzone(GO:0051233)
0.0	0.1	GO:0070531	BRCA1-A complex(GO:0070531)
0.0	0.4	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	0.1	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.1	GO:0000421	autophagosome membrane(GO:0000421)
0.0	0.2	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.6	GO:0031902	late endosome membrane(GO:0031902)
0.0	0.3	GO:0031907	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.1	0.2	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1	0.2	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1	0.2	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1	0.2	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.1	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.2	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.2	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0	0.3	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.1	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.1	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.1	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.3	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.3	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
0.0	0.1	GO:0017089	glycolipid transporter activity(GO:0017089)
0.0	0.1	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.2	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.1	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.1	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.1	GO:0004738	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.1	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.1	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.3	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0005148	prolactin receptor binding(GO:0005148)
0.0	0.1	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.1	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.2	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0	0.1	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.2	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.3	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.1	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.1	GO:0016421	CoA carboxylase activity(GO:0016421)
0.0	0.4	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.0	0.1	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.2	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.2	GO:0015377	cation:chloride symporter activity(GO:0015377)
0.0	0.2	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.1	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.1	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.0	0.1	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.1	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.0	0.1	GO:0008934	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.1	GO:0032452	histone demethylase activity(GO:0032452)
0.0	0.1	GO:0003988	acetyl-CoA C-acyltransferase activity(GO:0003988)
0.0	0.2	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.1	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.1	GO:0002060	nucleobase binding(GO:0002054) purine nucleobase binding(GO:0002060)
0.0	0.1	GO:0032554	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.6	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.1	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.1	GO:0016417	S-acyltransferase activity(GO:0016417)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.5	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.1	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.0	GO:0000033	alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0	0.0	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.2	GO:0031078	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0	0.0	GO:0008192	RNA guanylyltransferase activity(GO:0008192)
0.0	0.0	GO:0019863	IgE binding(GO:0019863)
0.0	0.1	GO:0016406	carnitine O-acyltransferase activity(GO:0016406)
0.0	0.1	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.1	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.1	GO:0034452	dynactin binding(GO:0034452)
0.0	0.3	GO:0008373	sialyltransferase activity(GO:0008373)
0.0	0.0	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.2	GO:0000155	phosphorelay sensor kinase activity(GO:0000155)
0.0	0.1	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.0	0.1	GO:0005123	death receptor binding(GO:0005123)
0.0	0.1	GO:0000295	adenine nucleotide transmembrane transporter activity(GO:0000295) purine nucleotide transmembrane transporter activity(GO:0015216)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.1	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.1	GO:0004339	glucan 1,4-alpha-glucosidase activity(GO:0004339)
0.0	0.0	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.1	GO:0008518	reduced folate carrier activity(GO:0008518)
0.0	0.1	GO:0004690	cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.0	GO:0015199	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0	0.6	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.0	GO:0045159	myosin II binding(GO:0045159)
0.0	0.2	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.1	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0030371	translation repressor activity(GO:0030371)
0.0	0.1	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.0	0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.0	GO:0004307	ethanolaminephosphotransferase activity(GO:0004307)
0.0	0.0	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.1	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.0	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.0	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.1	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.0	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.1	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)
0.0	0.1	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.0	GO:0019797	procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0	0.1	GO:0031404	chloride ion binding(GO:0031404)
0.0	0.0	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.0	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	0.0	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.3	GO:0019212	phosphatase inhibitor activity(GO:0019212)
0.0	0.0	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.1	GO:0051635	obsolete bacterial cell surface binding(GO:0051635)
0.0	0.0	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.1	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.1	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.0	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.1	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.0	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.0	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.2	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0	0.1	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.1	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.0	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.1	GO:0035251	UDP-glucosyltransferase activity(GO:0035251)
0.0	0.0	GO:0034481	chondroitin sulfotransferase activity(GO:0034481)
0.0	0.0	GO:0070052	collagen V binding(GO:0070052)
0.0	0.0	GO:0016454	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.2	GO:0016505	peptidase activator activity involved in apoptotic process(GO:0016505)
0.0	0.1	GO:0030169	low-density lipoprotein particle binding(GO:0030169)
0.0	0.0	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.0	0.5	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0008409	5'-3' exonuclease activity(GO:0008409)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.1	GO:0008504	monoamine transmembrane transporter activity(GO:0008504)
0.0	0.0	GO:0019958	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.0	GO:0045118	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.1	GO:0016846	carbon-sulfur lyase activity(GO:0016846)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.1	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.0	GO:0004689	phosphorylase kinase activity(GO:0004689)
0.0	0.1	GO:0032405	MutLalpha complex binding(GO:0032405)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.5	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.9	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.5	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.3	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.2	PID IL5 PATHWAY	IL5-mediated signaling events
0.2	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.2	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.3	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.5	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.7	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.1	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.6	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.4	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.5	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.2	PID EPO PATHWAY	EPO signaling pathway
0.3	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.3	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.0	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.1	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.3	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.2	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.1	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.2	PID BCR 5PATHWAY	BCR signaling pathway
0.5	PID RHOA PATHWAY	RhoA signaling pathway
0.3	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.1	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.2	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.3	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.8	PID CMYB PATHWAY	C-MYB transcription factor network
0.1	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.1	PID INSULIN PATHWAY	Insulin Pathway
0.2	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	PID ERBB1 RECEPTOR PROXIMAL PATHWAY	EGF receptor (ErbB1) signaling pathway
0.2	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.1	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.1	PID TRAIL PATHWAY	TRAIL signaling pathway
0.0	SIG CHEMOTAXIS	Genes related to chemotaxis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.3	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.1	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.4	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.4	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	REACTOME DAG AND IP3 SIGNALING	Genes involved in DAG and IP3 signaling
0.7	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.2	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.3	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.3	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.0	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.1	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.3	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.3	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.3	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.3	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.2	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.4	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.3	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.3	REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.1	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.2	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1	REACTOME IL 2 SIGNALING	Genes involved in Interleukin-2 signaling
0.1	REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.2	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.4	REACTOME IL 3 5 AND GM CSF SIGNALING	Genes involved in Interleukin-3, 5 and GM-CSF signaling
0.2	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.1	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.2	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.2	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.3	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.1	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.1	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.2	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.2	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.1	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.1	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.5	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.1	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.0	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.6	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.1	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.1	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.1	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.2	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.1	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.1	REACTOME PIP3 ACTIVATES AKT SIGNALING	Genes involved in PIP3 activates AKT signaling

Results for BRCA1

Z-value: 1.45

Motif logo

Transcription factors associated with BRCA1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the BRCA1 motif across conditions

Conditions sorted by the z-value of the BRCA1 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of BRCA1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: