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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for CEBPB

Z-value: 1.89

Motif logo

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Transcription factors associated with CEBPB

Gene Symbol Gene ID Gene Info
CEBPB
ENSG00000172216.4 CEBPB

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
CEBPBchr20_48893065_48893216857640.0789340.863.2e-03Click!
CEBPBchr20_48890286_48890437829850.0823110.827.3e-03Click!
CEBPBchr20_48843063_48843214357620.1649600.808.9e-03Click!
CEBPBchr20_48913935_489140861066340.0583440.781.4e-02Click!
CEBPBchr20_48887644_48887838803650.0856440.761.7e-02Click!

Activity of the CEBPB motif across conditions

Conditions sorted by the z-value of the CEBPB motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr11_104827364_104827515 1.18 CASP4
 caspase 4, apoptosis-related cysteine peptidase
 14
 0.98
chr9_132650035_132650502 0.82 FNBP1
 formin binding protein 1
 31321
 0.13
chr1_89339742_89339893 0.78 GTF2B
 general transcription factor IIB
 17362
 0.19
chr13_31312055_31312206 0.75 ALOX5AP
 arachidonate 5-lipoxygenase-activating protein
 2485
 0.4
chr17_56365676_56365827 0.73 MPO
 myeloperoxidase
 7455
 0.13
chr22_17588053_17588350 0.72 CECR6
 cat eye syndrome chromosome region, candidate 6
 13942
 0.14
chr1_223310789_223310940 0.71 TLR5
 toll-like receptor 5
 235
 0.96
chr12_54693878_54694144 0.71 NFE2
 nuclear factor, erythroid 2
 788
 0.32
chr9_132106265_132106416 0.70 ENSG00000242281
 .
 26400
 0.19
chr8_37739073_37739224 0.70 RAB11FIP1
 RAB11 family interacting protein 1 (class I)
 3513
 0.18
chr7_33089731_33090334 0.69 ENSG00000241420
 .
 4330
 0.18
chr9_93564472_93565060 0.67 SYK
 spleen tyrosine kinase
 557
 0.87
chr15_94406450_94406737 0.67 ENSG00000222409
 .
 33663
 0.25
chr19_43097999_43098150 0.64 CEACAM8
 carcinoembryonic antigen-related cell adhesion molecule 8
 1008
 0.56
chr6_34240254_34240462 0.63 C6orf1
 chromosome 6 open reading frame 1
 23111
 0.18
chr21_35889691_35889842 0.62 KCNE1
 potassium voltage-gated channel, Isk-related family, member 1
 5193
 0.21
chr21_43615613_43615764 0.61 ABCG1
 ATP-binding cassette, sub-family G (WHITE), member 1
 4111
 0.23
chr15_101782791_101782964 0.61 CHSY1
 chondroitin sulfate synthase 1
 9260
 0.18
chr4_121736506_121736657 0.60 ENSG00000212359
 .
 4957
 0.33
chr12_54893043_54893194 0.60 NCKAP1L
 NCK-associated protein 1-like
 550
 0.7
chr4_26275263_26275414 0.59 RBPJ
 recombination signal binding protein for immunoglobulin kappa J region
 1109
 0.68
chr1_212781685_212782134 0.59 ATF3
 activating transcription factor 3
 103
 0.96
chr1_167199348_167199534 0.58 POU2F1
 POU class 2 homeobox 1
 9298
 0.18
chr11_75473950_75474101 0.57 DGAT2
 diacylglycerol O-acyltransferase 2
 3468
 0.13
chr4_36312312_36312717 0.57 DTHD1
 death domain containing 1
 26870
 0.2
chr19_54327344_54327551 0.56 NLRP12
 NLR family, pyrin domain containing 12
 124
 0.86
chr6_106970433_106970694 0.56 AIM1
 absent in melanoma 1
 10833
 0.2
chr2_64447057_64447208 0.56 AC074289.1
7863
 0.27
chr6_106898099_106898250 0.56 ENSG00000202386
 .
 918
 0.54
chr4_40202894_40203061 0.55 RHOH
 ras homolog family member H
 1013
 0.59
chr17_8323121_8323272 0.55 NDEL1
 nudE neurodevelopment protein 1-like 1
 6747
 0.12
chr12_54701075_54701275 0.55 COPZ1
 coatomer protein complex, subunit zeta 1
 6189
 0.08
chr11_94989698_94989849 0.55 RP11-712B9.2
24038
 0.21
chr3_137854795_137854946 0.54 A4GNT
 alpha-1,4-N-acetylglucosaminyltransferase
 3641
 0.23
chr7_37425762_37425913 0.54 ELMO1
 engulfment and cell motility 1
 32565
 0.15
chr15_80282157_80282308 0.54 BCL2A1
 BCL2-related protein A1
 18444
 0.18
chr13_98039572_98039723 0.53 ENSG00000202290
 .
 24292
 0.19
chr1_112198825_112198976 0.53 ENSG00000201028
 .
 5741
 0.2
chr16_84421_84572 0.52 WASIR2
 WASH and IL9R antisense RNA 2
 11586
 0.1
chr1_38311557_38311777 0.52 MTF1
 metal-regulatory transcription factor 1
 13625
 0.09
chr8_52782524_52782885 0.52 PCMTD1
 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
 24399
 0.15
chr1_92057104_92057255 0.52 CDC7
 cell division cycle 7
 90484
 0.09
chr1_89737700_89738180 0.51 GBP5
 guanylate binding protein 5
 547
 0.77
chr22_18260050_18260218 0.51 BID
 BH3 interacting domain death agonist
 2703
 0.26
chr16_85793045_85793254 0.51 C16orf74
 chromosome 16 open reading frame 74
 8414
 0.11
chr12_51715569_51715862 0.51 BIN2
 bridging integrator 2
 2184
 0.26
chr8_37731641_37731792 0.51 RAB11FIP1
 RAB11 family interacting protein 1 (class I)
 3919
 0.18
chr20_19409135_19409286 0.51 ENSG00000221748
 .
 87270
 0.09
chr10_3825891_3827255 0.50 KLF6
 Kruppel-like factor 6
 812
 0.68
chr3_69246175_69246326 0.49 FRMD4B
 FERM domain containing 4B
 2171
 0.39
chr9_36144726_36145049 0.49 GLIPR2
 GLI pathogenesis-related 2
 8145
 0.19
chr17_73308701_73308852 0.48 GRB2
 growth factor receptor-bound protein 2
 9058
 0.1
chr4_38787577_38787728 0.48 TLR10
 toll-like receptor 10
 3042
 0.21
chr2_101944298_101944469 0.48 ENSG00000264857
 .
 18471
 0.16
chr13_28006863_28007014 0.48 GTF3A
 general transcription factor IIIA
 2843
 0.23
chr6_138132955_138133132 0.48 RP11-356I2.4
13988
 0.21
chr2_74197024_74197175 0.48 ENSG00000201876
 .
 1766
 0.3
chr3_34198432_34198583 0.48 PDCD6IP
 programmed cell death 6 interacting protein
 358392
 0.01
chr9_139267151_139267437 0.48 CARD9
 caspase recruitment domain family, member 9
 839
 0.45
chr2_71680397_71681534 0.47 DYSF
 dysferlin
 113
 0.98
chr2_113870439_113870728 0.47 IL1RN
 interleukin 1 receptor antagonist
 1890
 0.26
chr13_115091452_115091603 0.47 CHAMP1
 chromosome alignment maintaining phosphoprotein 1
 4926
 0.2
chr10_14614242_14614420 0.47 FAM107B
 family with sequence similarity 107, member B
 7
 0.98
chr17_10018615_10018977 0.47 GAS7
 growth arrest-specific 7
 926
 0.61
chr5_114820222_114820373 0.46 FEM1C
 fem-1 homolog c (C. elegans)
 60294
 0.12
chr17_45743155_45743306 0.46 KPNB1
 karyopherin (importin) beta 1
 2501
 0.2
chr5_69770149_69770300 0.46 RP11-497H16.7
949
 0.7
chr5_171560548_171560699 0.45 ENSG00000266671
 .
 52643
 0.12
chr9_130217644_130218078 0.45 LRSAM1
 leucine rich repeat and sterile alpha motif containing 1
 3327
 0.15
chr5_68915008_68915159 0.45 RP11-848G14.2
943
 0.58
chr7_112062054_112062259 0.45 IFRD1
 interferon-related developmental regulator 1
 867
 0.64
chr1_110415998_110416149 0.45 RP11-195M16.1
12813
 0.17
chr5_70423555_70423706 0.45 ENSG00000238451
 .
 39171
 0.18
chr5_149791833_149792018 0.45 CD74
 CD74 molecule, major histocompatibility complex, class II invariant chain
 370
 0.85
chr5_70298657_70298808 0.45 NAIP
 NLR family, apoptosis inhibitory protein
 17805
 0.22
chr2_200603876_200604217 0.44 FTCDNL1
 formiminotransferase cyclodeaminase N-terminal like
 111550
 0.07
chr10_28633323_28633474 0.44 MPP7
 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
 9983
 0.22
chr10_134407309_134407460 0.44 INPP5A
 inositol polyphosphate-5-phosphatase, 40kDa
 14046
 0.24
chr17_33850543_33850694 0.44 RP11-1094M14.5
13329
 0.11
chr1_203273901_203274091 0.44 BTG2
 BTG family, member 2
 668
 0.68
chr5_69423238_69423389 0.44 ENSG00000265577
 .
 52640
 0.15
chr14_88461258_88461409 0.43 GALC
 galactosylceramidase
 1324
 0.33
chr19_8634583_8634824 0.43 MYO1F
 myosin IF
 7619
 0.12
chr6_144474026_144474323 0.43 STX11
 syntaxin 11
 2511
 0.36
chr15_80262648_80263745 0.43 BCL2A1
 BCL2-related protein A1
 315
 0.89
chr12_9911079_9911493 0.42 CD69
 CD69 molecule
 2211
 0.26
chr5_118609234_118609422 0.42 TNFAIP8
 tumor necrosis factor, alpha-induced protein 8
 4879
 0.21
chr2_233941000_233941299 0.42 INPP5D
 inositol polyphosphate-5-phosphatase, 145kDa
 15960
 0.18
chr2_160418591_160418742 0.42 ENSG00000207117
 .
 25809
 0.19
chr17_29645268_29645505 0.41 CTD-2370N5.3
272
 0.86
chr2_159070755_159070906 0.41 CCDC148-AS1
 CCDC148 antisense RNA 1
 47668
 0.16
chr5_158639058_158639320 0.41 RNF145
 ring finger protein 145
 2128
 0.25
chr18_54111502_54111653 0.41 TXNL1
 thioredoxin-like 1
 170145
 0.04
chr10_109449257_109449408 0.41 ENSG00000200079
 .
 228014
 0.02
chr5_76152476_76152645 0.41 S100Z
 S100 calcium binding protein Z
 6636
 0.18
chr9_79230110_79230472 0.40 PRUNE2
 prune homolog 2 (Drosophila)
 37174
 0.16
chr2_209048796_209048947 0.39 C2orf80
 chromosome 2 open reading frame 80
 1123
 0.39
chr7_37009137_37009288 0.39 ELMO1
 engulfment and cell motility 1
 15453
 0.2
chr17_68166405_68166607 0.39 KCNJ2
 potassium inwardly-rectifying channel, subfamily J, member 2
 830
 0.45
chr11_118111552_118111703 0.39 MPZL3
 myelin protein zero-like 3
 11435
 0.13
chr11_44991792_44991943 0.39 TP53I11
 tumor protein p53 inducible protein 11
 19259
 0.24
chrX_39610263_39610414 0.39 ENSG00000264618
 .
 35739
 0.21
chr4_38857928_38858431 0.38 TLR6
 toll-like receptor 6
 258
 0.48
chr6_41169275_41169428 0.38 TREML2
 triggering receptor expressed on myeloid cells-like 2
 419
 0.77
chr3_169762562_169762818 0.38 GPR160
 G protein-coupled receptor 160
 4953
 0.16
chr9_123922153_123922304 0.38 CNTRL
 centriolin
 2107
 0.3
chr6_116950636_116950920 0.38 RSPH4A
 radial spoke head 4 homolog A (Chlamydomonas)
 12991
 0.16
chr2_38871082_38871242 0.38 GALM
 galactose mutarotase (aldose 1-epimerase)
 21890
 0.15
chr20_58630648_58631293 0.38 C20orf197
 chromosome 20 open reading frame 197
 10
 0.98
chr2_169928702_169928853 0.38 DHRS9
 dehydrogenase/reductase (SDR family) member 9
 233
 0.94
chr3_10231782_10231933 0.38 IRAK2
 interleukin-1 receptor-associated kinase 2
 25308
 0.1
chr15_55695695_55695873 0.38 CCPG1
 cell cycle progression 1
 4466
 0.19
chr3_128374531_128374682 0.38 RPN1
 ribophorin I
 4914
 0.23
chr20_10485640_10485791 0.38 SLX4IP
 SLX4 interacting protein
 69764
 0.11
chr11_46025287_46025438 0.37 PHF21A
 PHD finger protein 21A
 57942
 0.1
chr19_43032769_43032982 0.37 CEACAM1
 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
 214
 0.93
chr1_153337646_153337797 0.37 S100A9
 S100 calcium binding protein A9
 7391
 0.11
chr11_64114770_64114921 0.37 CCDC88B
 coiled-coil domain containing 88B
 1458
 0.2
chr12_69181196_69181347 0.36 AC124890.1
 HCG1774533, isoform CRA_a; PRO2268; Uncharacterized protein
 4854
 0.17
chr15_66662520_66662887 0.36 TIPIN
 TIMELESS interacting protein
 13649
 0.11
chr8_145002840_145002991 0.36 PLEC
 plectin
 1736
 0.23
chr8_37731176_37731327 0.36 RAB11FIP1
 RAB11 family interacting protein 1 (class I)
 4384
 0.17
chr12_32120805_32121101 0.36 KIAA1551
 KIAA1551
 5530
 0.26
chr4_124666055_124666206 0.36 SPRY1
 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
 345007
 0.01
chr6_147643085_147643755 0.36 STXBP5
 syntaxin binding protein 5 (tomosyn)
 4889
 0.34
chr11_70163755_70163906 0.36 CTA-797E19.1
2204
 0.21
chr12_27391555_27391706 0.36 STK38L
 serine/threonine kinase 38 like
 5271
 0.29
chr10_26726645_26726796 0.36 APBB1IP
 amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
 412
 0.9
chr2_176868332_176868483 0.36 KIAA1715
 KIAA1715
 840
 0.61
chr2_7934753_7934904 0.35 ENSG00000221255
 .
 217856
 0.02
chr10_4096081_4096232 0.35 KLF6
 Kruppel-like factor 6
 268683
 0.02
chr1_90223075_90223276 0.35 ENSG00000239176
 .
 10702
 0.21
chr5_77805493_77806187 0.35 LHFPL2
 lipoma HMGIC fusion partner-like 2
 39134
 0.21
chr5_163343244_163343412 0.35 ENSG00000251998
 .
 120157
 0.07
chr6_54063055_54063206 0.35 MLIP
 muscular LMNA-interacting protein
 86822
 0.09
chr2_238167076_238167227 0.35 AC112715.2
 Uncharacterized protein
 1417
 0.54
chr11_104914891_104915295 0.35 CARD16
 caspase recruitment domain family, member 16
 941
 0.54
chr18_43470611_43470762 0.35 EPG5
 ectopic P-granules autophagy protein 5 homolog (C. elegans)
 22971
 0.2
chr5_133861629_133862874 0.35 JADE2
 jade family PHD finger 2
 76
 0.97
chr6_41996182_41996339 0.35 ENSG00000206875
 .
 10008
 0.15
chr2_40621333_40621484 0.34 SLC8A1
 solute carrier family 8 (sodium/calcium exchanger), member 1
 36012
 0.23
chrY_1550810_1551045 0.34 NA
 NA
 > 106
 NA
chr19_54885564_54885768 0.34 LAIR1
 leukocyte-associated immunoglobulin-like receptor 1
 3501
 0.14
chr5_88057335_88057486 0.34 MEF2C
 myocyte enhancer factor 2C
 62195
 0.12
chr3_37351986_37352375 0.34 GOLGA4
 golgin A4
 28506
 0.15
chr12_65032414_65032565 0.34 RP11-338E21.2
10365
 0.12
chr16_72965340_72965833 0.34 ENSG00000221799
 .
 53170
 0.13
chr20_20760867_20761018 0.34 ENSG00000264361
 .
 41568
 0.19
chr4_55575057_55575208 0.34 KIT
 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
 51047
 0.18
chr3_45729758_45730513 0.34 LIMD1-AS1
 LIMD1 antisense RNA 1
 239
 0.78
chr20_5717977_5718128 0.34 C20orf196
 chromosome 20 open reading frame 196
 12987
 0.26
chr13_31312703_31312943 0.34 ALOX5AP
 arachidonate 5-lipoxygenase-activating protein
 3178
 0.36
chrX_154027559_154027756 0.34 MPP1
 membrane protein, palmitoylated 1, 55kDa
 6015
 0.13
chr15_64984139_64984290 0.34 AC100830.4
3026
 0.15
chr8_97779057_97779208 0.34 CPQ
 carboxypeptidase Q
 5664
 0.34
chr19_54827917_54828068 0.34 LILRA5
 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
 3583
 0.12
chr4_139879629_139879991 0.34 RP11-371F15.3
20675
 0.19
chr17_65373728_65374565 0.33 PITPNC1
 phosphatidylinositol transfer protein, cytoplasmic 1
 125
 0.95
chr15_63539472_63539623 0.33 APH1B
 APH1B gamma secretase subunit
 28670
 0.18
chr10_134365004_134365155 0.33 INPP5A
 inositol polyphosphate-5-phosphatase, 40kDa
 13436
 0.21
chr5_75764900_75765051 0.33 IQGAP2
 IQ motif containing GTPase activating protein 2
 64726
 0.13
chr8_24151584_24151953 0.33 ADAM28
 ADAM metallopeptidase domain 28
 144
 0.97
chr3_172230166_172230317 0.33 TNFSF10
 tumor necrosis factor (ligand) superfamily, member 10
 11024
 0.25
chr17_38443685_38443884 0.33 CDC6
 cell division cycle 6
 101
 0.95
chrX_9431281_9431551 0.33 TBL1X
 transducin (beta)-like 1X-linked
 45
 0.99
chr1_174934321_174935265 0.33 RABGAP1L
 RAB GTPase activating protein 1-like
 888
 0.52
chrX_39631447_39631598 0.33 ENSG00000264618
 .
 14555
 0.27
chr14_64228721_64228872 0.32 ENSG00000252749
 .
 25634
 0.16
chr18_60128151_60128302 0.32 ZCCHC2
 zinc finger, CCHC domain containing 2
 62014
 0.12
chr9_101881133_101881552 0.32 TGFBR1
 transforming growth factor, beta receptor 1
 8715
 0.21
chr1_26601594_26601745 0.32 SH3BGRL3
 SH3 domain binding glutamic acid-rich protein like 3
 3998
 0.14
chr8_139204133_139204284 0.32 FAM135B
 family with sequence similarity 135, member B
 233550
 0.02
chr6_13295173_13295324 0.32 RP1-257A7.4
570
 0.76
chr19_823853_824004 0.32 LPPR3
 hsa-mir-3187
 1961
 0.15
chr9_107826999_107827201 0.32 ENSG00000201583
 .
 31937
 0.22
chr3_182978087_182978238 0.32 ENSG00000202502
 .
 1958
 0.34
chr14_92652024_92652175 0.32 CPSF2
 cleavage and polyadenylation specific factor 2, 100kDa
 30576
 0.17
chr19_51634092_51634243 0.32 SIGLEC9
 sialic acid binding Ig-like lectin 9
 3880
 0.11
chr12_1414903_1415054 0.32 RP5-951N9.2
80021
 0.09
chr10_81081747_81081898 0.31 ZMIZ1
 zinc finger, MIZ-type containing 1
 15847
 0.2
chr6_43757843_43757994 0.31 VEGFA
 vascular endothelial growth factor A
 15828
 0.18
chr6_10837683_10838466 0.31 MAK
 male germ cell-associated kinase
 654
 0.68
chr1_65399507_65400011 0.31 JAK1
 Janus kinase 1
 32428
 0.2
chrX_40008490_40008641 0.31 BCOR
 BCL6 corepressor
 2683
 0.42
chr3_4793867_4794159 0.31 ENSG00000239126
 .
 126373
 0.05
chr18_60920514_60920680 0.30 ENSG00000238988
 .
 58699
 0.1
chr7_76829078_76829397 0.30 FGL2
 fibrinogen-like 2
 94
 0.98
chrX_153275945_153276096 0.30 IRAK1
 interleukin-1 receptor-associated kinase 1
 3677
 0.13
chr4_84188698_84188849 0.30 COQ2
 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
 17145
 0.23
chr15_70755434_70755585 0.30 UACA
 uveal autoantigen with coiled-coil domains and ankyrin repeats
 239111
 0.02
chr2_11971800_11971951 0.30 ENSG00000265172
 .
 5237
 0.22
chr6_88609819_88609970 0.30 ENSG00000211983
 .
 52544
 0.13
chrX_1600809_1601304 0.30 ASMTL
 acetylserotonin O-methyltransferase-like
 28401
 0.16
chr17_76748108_76748259 0.30 CYTH1
 cytohesin 1
 15211
 0.18
chr3_151960824_151960975 0.30 MBNL1
 muscleblind-like splicing regulator 1
 24930
 0.2
chr3_171853122_171853273 0.30 FNDC3B
 fibronectin type III domain containing 3B
 8433
 0.29
chr14_24743427_24743578 0.30 RABGGTA
 Rab geranylgeranyltransferase, alpha subunit
 2557
 0.1
chr5_149060859_149061010 0.30 ENSG00000221043
 .
 14588
 0.16
chr10_28794428_28794579 0.30 WAC-AS1
 WAC antisense RNA 1 (head to head)
 26780
 0.17
chrX_49853365_49853516 0.29 CLCN5
 chloride channel, voltage-sensitive 5
 19284
 0.14

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of CEBPB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0070340 detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.2 0.7 GO:0052033 pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308) positive regulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052555) positive regulation by symbiont of host immune response(GO:0052556)
0.2 0.6 GO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.2 0.5 GO:0032621 interleukin-18 production(GO:0032621) regulation of interleukin-18 production(GO:0032661)
0.2 0.5 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.1 0.4 GO:0030011 maintenance of cell polarity(GO:0030011)
0.1 0.4 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.4 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.1 0.3 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 0.4 GO:0016102 retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.1 0.4 GO:1903313 positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.1 0.2 GO:0010831 positive regulation of myotube differentiation(GO:0010831)
0.1 0.5 GO:0006337 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.1 0.2 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.1 0.3 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 0.2 GO:0002248 connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.1 0.1 GO:0031062 positive regulation of histone methylation(GO:0031062) positive regulation of histone H3-K4 methylation(GO:0051571)
0.1 0.1 GO:0034139 regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.1 0.2 GO:0046398 UDP-glucuronate metabolic process(GO:0046398)
0.1 0.3 GO:0031061 negative regulation of histone methylation(GO:0031061)
0.1 0.2 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.1 0.2 GO:0032495 response to muramyl dipeptide(GO:0032495)
0.1 0.4 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.0 GO:0052509 modulation by symbiont of host defense response(GO:0052031) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553)
0.0 0.2 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.2 GO:0006681 galactosylceramide metabolic process(GO:0006681)
0.0 0.2 GO:0001878 response to yeast(GO:0001878)
0.0 0.1 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.1 GO:0043312 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 0.2 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0 0.1 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.0 0.1 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.0 0.2 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0 0.3 GO:0010324 phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0 0.2 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.2 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.2 GO:0060081 membrane hyperpolarization(GO:0060081)
0.0 0.2 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.1 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.1 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0 0.1 GO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0 0.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0 0.2 GO:0033261 obsolete regulation of S phase(GO:0033261)
0.0 0.1 GO:0070672 response to interleukin-15(GO:0070672)
0.0 0.1 GO:0030910 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 0.1 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:0018243 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.1 GO:0007100 mitotic centrosome separation(GO:0007100)
0.0 0.0 GO:0002246 wound healing involved in inflammatory response(GO:0002246) inflammatory response to wounding(GO:0090594)
0.0 0.1 GO:0000154 rRNA modification(GO:0000154)
0.0 0.3 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.1 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.1 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.1 GO:0018027 peptidyl-lysine dimethylation(GO:0018027)
0.0 0.2 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0 0.1 GO:0002634 regulation of germinal center formation(GO:0002634)
0.0 0.2 GO:0045717 negative regulation of fatty acid biosynthetic process(GO:0045717)
0.0 0.1 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.0 0.2 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.2 GO:0000132 establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0 0.1 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0 0.1 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.1 GO:0051873 disruption by host of symbiont cells(GO:0051852) killing by host of symbiont cells(GO:0051873)
0.0 0.1 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.0 GO:0051459 corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0 0.0 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.0 0.5 GO:0050715 positive regulation of cytokine secretion(GO:0050715)
0.0 0.1 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.1 GO:0060017 parathyroid gland development(GO:0060017)
0.0 0.1 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.2 GO:0008653 lipopolysaccharide metabolic process(GO:0008653)
0.0 0.0 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.0 0.0 GO:1903429 regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0 0.3 GO:0046834 lipid phosphorylation(GO:0046834)
0.0 0.1 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.1 GO:0032875 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0 0.1 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.1 GO:0090231 regulation of spindle checkpoint(GO:0090231)
0.0 0.1 GO:0001821 histamine secretion(GO:0001821)
0.0 0.4 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.1 GO:0035268 protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.0 0.1 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.0 GO:0006000 fructose metabolic process(GO:0006000)
0.0 0.1 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 0.1 GO:0090022 regulation of neutrophil chemotaxis(GO:0090022) regulation of neutrophil migration(GO:1902622)
0.0 0.0 GO:0034122 negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.0 0.1 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.1 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) extrinsic apoptotic signaling pathway(GO:0097191)
0.0 0.1 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.0 GO:0052173 response to defenses of other organism involved in symbiotic interaction(GO:0052173) response to host defenses(GO:0052200) response to host(GO:0075136)
0.0 0.1 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.1 GO:0030187 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0 0.1 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.3 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.1 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.1 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.0 0.0 GO:0032494 response to peptidoglycan(GO:0032494)
0.0 0.0 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.3 GO:0018200 peptidyl-glutamic acid modification(GO:0018200)
0.0 0.1 GO:0047496 vesicle transport along microtubule(GO:0047496) vesicle cytoskeletal trafficking(GO:0099518)
0.0 0.0 GO:0009120 deoxyribonucleoside metabolic process(GO:0009120)
0.0 0.1 GO:0010452 histone H3-K36 methylation(GO:0010452)
0.0 0.1 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.0 GO:0014742 positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.0 0.1 GO:0032898 neurotrophin production(GO:0032898)
0.0 0.1 GO:0015884 folic acid transport(GO:0015884)
0.0 0.0 GO:0006154 adenosine catabolic process(GO:0006154)
0.0 0.1 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.1 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.0 0.3 GO:0060330 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 0.1 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
0.0 0.1 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.1 GO:0045651 positive regulation of macrophage differentiation(GO:0045651)
0.0 0.0 GO:0030432 peristalsis(GO:0030432)
0.0 0.1 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.1 GO:0071320 cellular response to cAMP(GO:0071320)
0.0 0.0 GO:0070102 interleukin-6-mediated signaling pathway(GO:0070102)
0.0 0.0 GO:0002423 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0 0.1 GO:0071549 response to dexamethasone(GO:0071548) cellular response to dexamethasone stimulus(GO:0071549)
0.0 0.1 GO:0071027 RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.0 0.0 GO:0071800 podosome assembly(GO:0071800)
0.0 0.0 GO:0045579 positive regulation of B cell differentiation(GO:0045579)
0.0 0.1 GO:0015671 oxygen transport(GO:0015671)
0.0 0.0 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.0 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.0 0.0 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.0 GO:0042339 keratan sulfate metabolic process(GO:0042339)
0.0 0.1 GO:0002279 mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.0 0.3 GO:0006071 glycerol metabolic process(GO:0006071)
0.0 0.0 GO:0033688 regulation of osteoblast proliferation(GO:0033688)
0.0 0.2 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.1 GO:0031017 exocrine pancreas development(GO:0031017)
0.0 0.0 GO:0034625 fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0 0.1 GO:0046501 protoporphyrinogen IX metabolic process(GO:0046501)
0.0 0.1 GO:0044803 multi-organism membrane organization(GO:0044803)
0.0 0.0 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.0 GO:0002532 production of molecular mediator involved in inflammatory response(GO:0002532)
0.0 0.0 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.0 GO:0043320 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0 0.2 GO:0007030 Golgi organization(GO:0007030)
0.0 0.1 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.0 0.1 GO:0014002 astrocyte development(GO:0014002)
0.0 0.6 GO:0019319 hexose biosynthetic process(GO:0019319)
0.0 0.0 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.0 GO:0042816 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0 0.1 GO:0045576 mast cell activation(GO:0045576)
0.0 0.0 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.0 0.0 GO:0046476 glycosylceramide biosynthetic process(GO:0046476)
0.0 0.0 GO:0042119 neutrophil activation(GO:0042119)
0.0 0.1 GO:0001960 negative regulation of cytokine-mediated signaling pathway(GO:0001960)
0.0 0.0 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.1 GO:0045730 respiratory burst(GO:0045730)
0.0 0.3 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 0.0 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.1 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.0 GO:0046835 carbohydrate phosphorylation(GO:0046835)
0.0 0.0 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.0 0.1 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.0 0.0 GO:0045630 positive regulation of type 2 immune response(GO:0002830) positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.0 0.1 GO:0043101 purine-containing compound salvage(GO:0043101)
0.0 0.0 GO:0010829 negative regulation of glucose transport(GO:0010829) negative regulation of glucose import(GO:0046325)
0.0 0.1 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.2 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.0 0.1 GO:0001556 oocyte maturation(GO:0001556)
0.0 0.0 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.0 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.0 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247)
0.0 0.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.1 GO:0003341 cilium movement(GO:0003341)
0.0 0.0 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.0 0.1 GO:0010288 response to lead ion(GO:0010288)
0.0 0.1 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.1 GO:0031269 pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.0 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.0 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 0.1 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.4 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 0.2 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 0.2 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 0.4 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.3 GO:0051233 spindle midzone(GO:0051233)
0.1 0.6 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.0 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.1 GO:0005638 lamin filament(GO:0005638)
0.0 0.1 GO:0042629 mast cell granule(GO:0042629)
0.0 0.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0033150 cytoskeletal calyx(GO:0033150)
0.0 0.1 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.2 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.1 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.0 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.1 GO:0031501 mannosyltransferase complex(GO:0031501) dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 0.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.0 GO:0070552 BRISC complex(GO:0070552)
0.0 0.1 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.1 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.2 GO:0005675 holo TFIIH complex(GO:0005675)
0.0 0.1 GO:0001950 obsolete plasma membrane enriched fraction(GO:0001950)
0.0 0.3 GO:0032420 stereocilium(GO:0032420)
0.0 0.0 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.2 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.1 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.8 GO:0016605 PML body(GO:0016605)
0.0 0.1 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.0 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.0 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.1 GO:0042581 specific granule(GO:0042581)
0.0 0.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.0 GO:0000124 SAGA complex(GO:0000124)
0.0 0.0 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.0 GO:0030891 VCB complex(GO:0030891)
0.0 0.0 GO:0071547 piP-body(GO:0071547)
0.0 0.1 GO:0016235 aggresome(GO:0016235)
0.0 0.0 GO:0000800 lateral element(GO:0000800)
0.0 0.0 GO:0001740 Barr body(GO:0001740)
0.0 0.0 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.1 GO:0070822 Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822)
0.0 0.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.0 GO:0044462 external encapsulating structure part(GO:0044462)
0.0 0.1 GO:0070652 HAUS complex(GO:0070652)
0.0 0.1 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.0 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.1 GO:0030870 Mre11 complex(GO:0030870)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0050544 arachidonic acid binding(GO:0050544)
0.1 0.4 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 0.3 GO:0071723 lipopeptide binding(GO:0071723)
0.1 0.8 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 0.4 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1 0.4 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1 0.3 GO:0052743 inositol tetrakisphosphate phosphatase activity(GO:0052743)
0.1 0.2 GO:0055106 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.1 0.2 GO:0030151 molybdenum ion binding(GO:0030151)
0.1 0.3 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.1 0.2 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.1 0.3 GO:0004904 interferon receptor activity(GO:0004904)
0.1 0.6 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.1 0.3 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 0.2 GO:0008061 chitin binding(GO:0008061)
0.0 0.4 GO:0019864 IgG binding(GO:0019864)
0.0 0.1 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.8 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.1 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.1 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.2 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.1 GO:0019959 C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0 0.1 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.1 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.0 0.2 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol trisphosphate phosphatase activity(GO:0046030)
0.0 0.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.2 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.6 GO:0050699 WW domain binding(GO:0050699)
0.0 0.4 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 1.8 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.1 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.1 GO:0008517 folic acid transporter activity(GO:0008517)
0.0 0.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.1 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 0.1 GO:0019956 chemokine binding(GO:0019956)
0.0 0.1 GO:0042808 obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0 0.1 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.0 0.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)
0.0 0.2 GO:0005123 death receptor binding(GO:0005123)
0.0 0.1 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.1 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.1 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.1 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.1 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0 0.0 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0 0.1 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.2 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.0 0.2 GO:0051920 peroxiredoxin activity(GO:0051920)
0.0 0.0 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.1 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.1 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.1 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0 0.3 GO:0004835 tubulin-tyrosine ligase activity(GO:0004835)
0.0 0.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.1 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 0.1 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.0 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0 0.1 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.1 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 0.1 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.0 GO:0042156 obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0 0.0 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.0 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0 0.1 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.0 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.1 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.0 GO:0016505 peptidase activator activity involved in apoptotic process(GO:0016505)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.1 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.4 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 0.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.2 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.1 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.3 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.2 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.1 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.0 GO:0034584 piRNA binding(GO:0034584)
0.0 0.4 GO:0002039 p53 binding(GO:0002039)
0.0 0.1 GO:0003709 obsolete RNA polymerase III transcription factor activity(GO:0003709)
0.0 0.2 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.2 GO:0019894 kinesin binding(GO:0019894)
0.0 0.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.2 GO:0017127 cholesterol transporter activity(GO:0017127)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.1 GO:0051184 cofactor transporter activity(GO:0051184)
0.0 0.1 GO:0004340 glucokinase activity(GO:0004340)
0.0 0.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.1 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.0 GO:0016149 translation release factor activity, codon specific(GO:0016149)
0.0 0.1 GO:0015368 calcium:cation antiporter activity(GO:0015368)
0.0 0.0 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.0 GO:0004308 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0 0.0 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.0 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.1 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.0 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.0 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.1 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.0 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.0 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.1 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.0 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.1 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0 0.1 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.1 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.0 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.1 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.0 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.0 0.3 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076) RNA polymerase II transcription cofactor activity(GO:0001104)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 1.9 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.9 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.1 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 0.1 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.2 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.5 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.1 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.1 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.2 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.6 PID ATR PATHWAY ATR signaling pathway
0.0 0.3 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.1 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.1 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.0 0.4 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.1 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.3 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.2 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.1 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.5 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.2 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.1 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.1 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.2 PID ARF 3PATHWAY Arf1 pathway
0.0 0.1 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.0 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.0 0.2 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.0 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 0.1 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.3 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.2 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME SIGNALING BY THE B CELL RECEPTOR BCR Genes involved in Signaling by the B Cell Receptor (BCR)
0.1 1.8 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 0.1 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.6 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.9 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.6 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.4 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.1 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.2 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.2 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.3 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.6 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.2 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 2.0 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.0 0.1 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.3 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 1.1 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.2 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.3 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.0 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.3 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.3 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.1 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.1 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 0.0 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.4 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.0 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.1 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.2 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.1 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.2 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.0 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.2 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.2 REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS Genes involved in Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
0.0 0.1 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.0 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.1 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.1 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling