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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for CREB1

Z-value: 0.33

Motif logo

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Transcription factors associated with CREB1

Gene Symbol Gene ID Gene Info
ENSG00000118260.10 CREB1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
CREB1chr2_208365436_208365587289500.1793530.742.1e-02Click!
CREB1chr2_208395473_2083957227690.5200900.608.9e-02Click!
CREB1chr2_208397856_20839800731030.254747-0.609.0e-02Click!
CREB1chr2_208462214_208462365222790.1633690.599.2e-02Click!
CREB1chr2_208395832_20839665714160.3739020.571.1e-01Click!

Activity of the CREB1 motif across conditions

Conditions sorted by the z-value of the CREB1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr17_20491916_20492779 0.18 CDRT15L2
CMT1A duplicated region transcript 15-like 2
9310
0.21
chr17_15689649_15690074 0.15 ENSG00000251829
.
4206
0.19
chr13_109792800_109793227 0.13 MYO16-AS2
MYO16 antisense RNA 2
38746
0.2
chr18_74773875_74774026 0.11 MBP
myelin basic protein
43267
0.18
chr1_57044587_57045121 0.11 PPAP2B
phosphatidic acid phosphatase type 2B
387
0.91
chr21_46961161_46962032 0.10 SLC19A1
solute carrier family 19 (folate transporter), member 1
156
0.96
chr6_116692035_116692441 0.10 DSE
dermatan sulfate epimerase
128
0.97
chr11_49455905_49456091 0.08 RP11-707M1.1

126372
0.06
chr4_39367062_39368041 0.08 RFC1
replication factor C (activator 1) 1, 145kDa
418
0.81
chrX_20135177_20135375 0.08 MAP7D2
MAP7 domain containing 2
241
0.9
chr8_687260_687856 0.08 ERICH1-AS1
ERICH1 antisense RNA 1
93
0.97
chr2_190444828_190446170 0.08 SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
114
0.98
chr9_17578628_17579355 0.08 SH3GL2
SH3-domain GRB2-like 2
130
0.98
chr20_32273512_32274295 0.07 E2F1
E2F transcription factor 1
307
0.81
chr19_41931658_41931809 0.07 CTC-435M10.6

469
0.62
chr14_92789494_92790350 0.07 SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
27
0.99
chr5_142782115_142782536 0.07 NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
23
0.99
chr3_154145836_154146602 0.07 GPR149
G protein-coupled receptor 149
1285
0.6
chrX_334679_335404 0.07 PPP2R3B
protein phosphatase 2, regulatory subunit B'', beta
262
0.94
chr12_93323322_93324013 0.06 EEA1
early endosome antigen 1
560
0.8
chr11_118230043_118230305 0.06 UBE4A
ubiquitination factor E4A
126
0.93
chr3_53276217_53276368 0.06 TKT
transketolase
13724
0.14
chr3_112279714_112280459 0.06 SLC35A5
solute carrier family 35, member A5
470
0.59
chrY_284683_285373 0.06 NA
NA
> 106
NA
chr7_37487305_37488000 0.06 ELMO1
engulfment and cell motility 1
901
0.61
chr19_10527476_10527700 0.06 PDE4A
phosphodiesterase 4A, cAMP-specific
31
0.95
chr21_35987336_35987662 0.06 RCAN1
regulator of calcineurin 1
58
0.98
chr15_74657875_74658107 0.06 CTD-2311M21.3

215
0.75
chr2_60962956_60963147 0.06 ENSG00000252718
.
16276
0.19
chr17_17380267_17380681 0.06 MED9
mediator complex subunit 9
166
0.94
chr7_119450_119601 0.05 FAM20C
family with sequence similarity 20, member C
73444
0.11
chr2_130939128_130939480 0.05 MZT2B
mitotic spindle organizing protein 2B
6
0.62
chr18_53446598_53447540 0.05 TCF4
transcription factor 4
115051
0.07
chr7_23145115_23145340 0.05 KLHL7
kelch-like family member 7
126
0.97
chrX_132548696_132549413 0.05 GPC4
glypican 4
464
0.88
chr3_71834358_71834666 0.05 PROK2
prokineticin 2
155
0.96
chr15_44092835_44093206 0.05 HYPK
huntingtin interacting protein K
223
0.57
chr17_34891354_34891543 0.05 PIGW
phosphatidylinositol glycan anchor biosynthesis, class W
45
0.91
chr1_9599629_9600173 0.05 SLC25A33
solute carrier family 25 (pyrimidine nucleotide carrier), member 33
360
0.89
chr8_59323967_59324678 0.05 UBXN2B
UBX domain protein 2B
499
0.88
chr17_1532581_1533057 0.05 SLC43A2
solute carrier family 43 (amino acid system L transporter), member 2
689
0.52
chr12_133022737_133022888 0.05 MUC8
mucin 8
27914
0.17
chr16_87526385_87526690 0.05 ZCCHC14
zinc finger, CCHC domain containing 14
886
0.63
chr20_47443528_47443935 0.05 PREX1
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
689
0.79
chr1_109940210_109941121 0.04 SORT1
sortilin 1
92
0.96
chr1_61549203_61549354 0.04 ENSG00000263380
.
76
0.94
chr2_26785075_26785548 0.04 C2orf70
chromosome 2 open reading frame 70
139
0.96
chr2_64836667_64836835 0.04 ENSG00000252414
.
30725
0.17
chr4_134072879_134073697 0.04 PCDH10
protocadherin 10
2818
0.44
chr9_34049001_34049202 0.04 UBAP2
ubiquitin associated protein 2
154
0.89
chr7_4901206_4901513 0.04 PAPOLB
poly(A) polymerase beta (testis specific)
266
0.91
chr11_9595385_9595551 0.04 WEE1
WEE1 G2 checkpoint kinase
240
0.9
chr7_140623410_140624534 0.04 BRAF
v-raf murine sarcoma viral oncogene homolog B
592
0.79
chrX_39548256_39548819 0.04 ENSG00000263730
.
28067
0.24
chr7_39894513_39894809 0.04 ENSG00000242855
.
33311
0.18
chr1_12040274_12040953 0.04 MFN2
mitofusin 2
244
0.89
chr9_96339036_96339199 0.04 PHF2
PHD finger protein 2
208
0.94
chr3_195384928_195385957 0.04 SDHAP2
succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 2
475
0.81
chrX_71933533_71934701 0.04 PHKA1
phosphorylase kinase, alpha 1 (muscle)
11
0.97
chr16_89159943_89160452 0.03 ACSF3
acyl-CoA synthetase family member 3
20
0.97
chr3_143689644_143690155 0.03 C3orf58
chromosome 3 open reading frame 58
741
0.8
chr3_87842154_87842380 0.03 ENSG00000200703
.
50468
0.17
chr2_27008928_27009181 0.03 CENPA
centromere protein A
118
0.96
chr5_170289344_170289797 0.03 RANBP17
RAN binding protein 17
696
0.71
chr18_52988378_52989650 0.03 TCF4
transcription factor 4
203
0.97
chr11_74442538_74442948 0.03 CHRDL2
chordin-like 2
313
0.84
chr3_49055259_49056395 0.03 DALRD3
DALR anticodon binding domain containing 3
170
0.84
chr2_74691535_74692741 0.03 MOGS
mannosyl-oligosaccharide glucosidase
351
0.67
chrX_138285953_138286466 0.03 FGF13
fibroblast growth factor 13
60
0.99
chr17_72732981_72733167 0.03 RAB37
RAB37, member RAS oncogene family
18
0.95
chr5_76506770_76507546 0.03 PDE8B
phosphodiesterase 8B
407
0.88
chr1_109642808_109643473 0.03 ENSG00000270066
.
325
0.81
chr4_6783649_6783989 0.03 KIAA0232
KIAA0232
550
0.79
chr15_70391403_70391876 0.03 TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
1124
0.58
chr4_174459155_174459419 0.03 HAND2-AS1
HAND2 antisense RNA 1 (head to head)
6591
0.22
chr15_80696207_80696642 0.03 ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
269
0.71
chr11_65547664_65548343 0.03 AP5B1
adaptor-related protein complex 5, beta 1 subunit
270
0.82
chr16_52580478_52580769 0.03 TOX3
TOX high mobility group box family member 3
297
0.95
chr3_69591903_69592054 0.03 FRMD4B
FERM domain containing 4B
244
0.96
chr18_74534859_74535018 0.03 ZNF236
zinc finger protein 236
375
0.68
chr1_245134150_245135065 0.03 RP11-156E8.1
Uncharacterized protein
217
0.85
chr3_125899243_125899606 0.03 ALDH1L1
aldehyde dehydrogenase 1 family, member L1
5
0.9
chr7_3340905_3341061 0.03 SDK1
sidekick cell adhesion molecule 1
97
0.95
chr2_100105997_100106148 0.03 REV1
REV1, polymerase (DNA directed)
363
0.89
chr10_130008645_130009418 0.03 MKI67
marker of proliferation Ki-67
84382
0.11
chr1_54410859_54411299 0.03 HSPB11
heat shock protein family B (small), member 11
166
0.86
chr9_131464565_131465241 0.03 PKN3
protein kinase N3
101
0.93
chr13_110437375_110437816 0.03 IRS2
insulin receptor substrate 2
1320
0.57
chr16_1359047_1359364 0.03 UBE2I
ubiquitin-conjugating enzyme E2I
51
0.94
chr14_50235014_50236034 0.03 KLHDC2
kelch domain containing 2
638
0.62
chr10_104210416_104210610 0.03 ENSG00000269609
.
125
0.87
chr2_7057645_7057806 0.03 RNF144A
ring finger protein 144A
202
0.9
chr9_140500205_140501463 0.03 ARRDC1
arrestin domain containing 1
679
0.56
chr17_74534170_74534513 0.03 CYGB
cytoglobin
354
0.7
chr2_136289143_136290038 0.03 R3HDM1
R3H domain containing 1
503
0.62
chr16_1470975_1471179 0.03 C16orf91
chromosome 16 open reading frame 91
276
0.79
chr3_69591491_69591662 0.02 FRMD4B
FERM domain containing 4B
158
0.98
chr2_190305327_190305991 0.02 WDR75
WD repeat domain 75
500
0.87
chr12_69633375_69633694 0.02 CPSF6
cleavage and polyadenylation specific factor 6, 68kDa
112
0.98
chr2_97482659_97482901 0.02 CNNM3
cyclin M3
793
0.53
chr16_3108546_3109349 0.02 RP11-473M20.7

139
0.86
chr10_103577050_103577916 0.02 MGEA5
meningioma expressed antigen 5 (hyaluronidase)
140
0.93
chr6_56820015_56820822 0.02 BEND6
BEN domain containing 6
248
0.86
chr19_8008965_8009156 0.02 TIMM44
translocase of inner mitochondrial membrane 44 homolog (yeast)
255
0.8
chr11_63766571_63766823 0.02 OTUB1
OTU domain, ubiquitin aldehyde binding 1
12383
0.11
chr8_21946490_21946833 0.02 FAM160B2
family with sequence similarity 160, member B2
58
0.96
chr16_54971520_54971850 0.02 IRX5
iroquois homeobox 5
5701
0.35
chr2_85938999_85939212 0.02 ENSG00000199687
.
16355
0.12
chr22_20104378_20104805 0.02 TRMT2A
tRNA methyltransferase 2 homolog A (S. cerevisiae)
154
0.7
chr12_115889903_115890336 0.02 RP11-116D17.1
HCG2038717; Uncharacterized protein
89302
0.1
chr15_52860024_52861356 0.02 ARPP19
cAMP-regulated phosphoprotein, 19kDa
339
0.87
chr1_63782781_63783608 0.02 RP4-792G4.2

4006
0.2
chr1_1589957_1590616 0.02 CDK11B
cyclin-dependent kinase 11B
187
0.75
chr1_22108808_22109469 0.02 USP48
ubiquitin specific peptidase 48
346
0.89
chr7_56019535_56020015 0.02 MRPS17
mitochondrial ribosomal protein S17
119
0.72
chr11_568685_568932 0.02 ENSG00000199038
.
610
0.48
chr19_13264252_13264621 0.02 CTC-250I14.6

90
0.93
chr9_132382165_132382732 0.02 C9orf50
chromosome 9 open reading frame 50
607
0.62
chr7_99156308_99157048 0.02 ZNF655
zinc finger protein 655
193
0.77
chr20_48595704_48595927 0.02 SNAI1
snail family zinc finger 1
3721
0.18
chr7_113724609_113725113 0.02 FOXP2
forkhead box P2
1754
0.44
chr10_108924530_108924681 0.02 SORCS1
sortilin-related VPS10 domain containing receptor 1
313
0.95
chr11_77185235_77185792 0.02 PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
167
0.92
chr2_61696387_61697458 0.02 USP34
ubiquitin specific peptidase 34
982
0.45
chr20_3994903_3996170 0.02 RNF24
ring finger protein 24
500
0.83
chr1_208132304_208132634 0.02 CD34
CD34 molecule
47722
0.19
chr15_74219902_74220340 0.02 LOXL1-AS1
LOXL1 antisense RNA 1
6
0.96
chr16_3207596_3208760 0.02 CASP16
caspase 16, apoptosis-related cysteine peptidase (putative)
13934
0.08
chr2_176944534_176944961 0.02 EVX2
even-skipped homeobox 2
3894
0.12
chr12_104531819_104531970 0.02 NFYB
nuclear transcription factor Y, beta
87
0.97
chr1_90460754_90461861 0.02 ZNF326
zinc finger protein 326
580
0.8
chr10_112403975_112404246 0.02 RBM20
RNA binding motif protein 20
45
0.96
chr1_233463556_233464041 0.02 MLK4
Mitogen-activated protein kinase kinase kinase MLK4
284
0.94
chrX_119149654_119149897 0.02 RP4-755D9.1

20426
0.16
chr9_134954308_134955306 0.02 MED27
mediator complex subunit 27
446
0.89
chr9_130699622_130700109 0.02 DPM2
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
257
0.5
chr4_74904304_74905084 0.02 CXCL3
chemokine (C-X-C motif) ligand 3
288
0.87
chrY_21238831_21239141 0.02 ENSG00000252766
.
58013
0.16
chr4_96469881_96470326 0.02 UNC5C
unc-5 homolog C (C. elegans)
20
0.69
chr3_142607235_142608274 0.02 PCOLCE2
procollagen C-endopeptidase enhancer 2
13
0.98
chr14_33408703_33409010 0.02 NPAS3
neuronal PAS domain protein 3
333
0.94
chr8_10696975_10697533 0.02 PINX1
PIN2/TERF1 interacting, telomerase inhibitor 1
27
0.57
chr1_9882638_9884014 0.02 CLSTN1
calsyntenin 1
716
0.65
chr8_135725075_135725586 0.02 ZFAT
zinc finger and AT hook domain containing
49
0.99
chr19_56156604_56156918 0.02 ZNF581
zinc finger protein 581
1585
0.15
chr9_77642770_77643186 0.02 C9orf41
chromosome 9 open reading frame 41
211
0.93
chr11_8290078_8290567 0.02 LMO1
LIM domain only 1 (rhombotin 1)
59
0.98
chr15_68155525_68155920 0.02 ENSG00000206625
.
23339
0.22
chr2_223155673_223155824 0.02 CCDC140
coiled-coil domain containing 140
7118
0.2
chr2_27578903_27579940 0.02 GTF3C2
general transcription factor IIIC, polypeptide 2, beta 110kDa
62
0.77
chr2_152493968_152494122 0.02 NEB
nebulin
53912
0.17
chr16_88870149_88870541 0.02 CDT1
chromatin licensing and DNA replication factor 1
724
0.48
chr7_155249437_155250320 0.02 EN2
engrailed homeobox 2
946
0.59
chr6_170921254_170921775 0.02 PDCD2
programmed cell death 2
27766
0.19
chr2_238395971_238396408 0.02 MLPH
melanophilin
270
0.92
chr13_53024209_53024738 0.02 VPS36
vacuolar protein sorting 36 homolog (S. cerevisiae)
284
0.9
chr10_28287400_28288216 0.02 ARMC4
armadillo repeat containing 4
169
0.97
chr3_100053843_100054079 0.02 NIT2
nitrilase family, member 2
306
0.91
chrX_334213_334384 0.02 PPP2R3B
protein phosphatase 2, regulatory subunit B'', beta
481
0.86
chr15_42840348_42841494 0.02 LRRC57
leucine rich repeat containing 57
49
0.54
chr14_100706520_100706671 0.02 YY1
YY1 transcription factor
499
0.64
chr6_101849901_101850127 0.02 GRIK2
glutamate receptor, ionotropic, kainate 2
2860
0.43
chr12_51818617_51818968 0.02 SLC4A8
solute carrier family 4, sodium bicarbonate cotransporter, member 8
109
0.81
chrY_284220_284379 0.02 NA
NA
> 106
NA
chr1_41249080_41249567 0.02 KCNQ4
potassium voltage-gated channel, KQT-like subfamily, member 4
361
0.82
chr3_197354198_197354750 0.02 AC024560.3

245
0.93
chr20_33413142_33413293 0.02 NCOA6
nuclear receptor coactivator 6
235
0.93
chrX_153402310_153402730 0.01 OPN1LW
opsin 1 (cone pigments), long-wave-sensitive
7178
0.14
chr22_51020587_51021277 0.01 CHKB
choline kinase beta
496
0.39
chr8_41997342_41997944 0.01 RP11-589C21.5

12638
0.17
chr6_137244870_137245021 0.01 SLC35D3
solute carrier family 35, member D3
1543
0.4
chr2_11051733_11051998 0.01 KCNF1
potassium voltage-gated channel, subfamily F, member 1
198
0.95
chr5_141404364_141404742 0.01 GNPDA1
glucosamine-6-phosphate deaminase 1
11947
0.17
chr20_307052_307593 0.01 SOX12
SRY (sex determining region Y)-box 12
1083
0.33
chr11_73498863_73499083 0.01 MRPL48
mitochondrial ribosomal protein L48
2
0.97
chr12_95942120_95942537 0.01 USP44
ubiquitin specific peptidase 44
246
0.94
chr11_64569817_64570601 0.01 MAP4K2
mitogen-activated protein kinase kinase kinase kinase 2
438
0.72
chr11_123525466_123525691 0.01 SCN3B
sodium channel, voltage-gated, type III, beta subunit
136
0.96
chr12_112546417_112546609 0.01 NAA25
N(alpha)-acetyltransferase 25, NatB auxiliary subunit
34
0.97
chr17_7144804_7145679 0.01 GABARAP
GABA(A) receptor-associated protein
103
0.89
chr17_8042262_8042413 0.01 PER1
period circadian clock 1
7005
0.08
chr10_70588000_70588364 0.01 STOX1
storkhead box 1
619
0.68
chr17_37910669_37910916 0.01 GRB7
growth factor receptor-bound protein 7
12287
0.11
chr7_35076877_35077068 0.01 DPY19L1
dpy-19-like 1 (C. elegans)
681
0.8
chr2_71115848_71116159 0.01 VAX2
ventral anterior homeobox 2
11717
0.13
chr3_96531977_96533205 0.01 EPHA6
EPH receptor A6
834
0.76
chr11_2466604_2466835 0.01 KCNQ1
potassium voltage-gated channel, KQT-like subfamily, member 1
498
0.74
chr16_84149538_84150449 0.01 MBTPS1
membrane-bound transcription factor peptidase, site 1
407
0.6
chr16_46660648_46660928 0.01 SHCBP1
SHC SH2-domain binding protein 1
5250
0.2
chr12_133405892_133406043 0.01 GOLGA3
golgin A3
528
0.72
chr10_12392249_12392465 0.01 CAMK1D
calcium/calmodulin-dependent protein kinase ID
625
0.72
chr2_28616306_28616795 0.01 FOSL2
FOS-like antigen 2
825
0.43
chr15_99557942_99558631 0.01 PGPEP1L
pyroglutamyl-peptidase I-like
7262
0.22
chr10_32636312_32636863 0.01 RP11-135A24.2

262
0.56
chr1_17248321_17248578 0.01 CROCC
ciliary rootlet coiled-coil, rootletin
4
0.97
chr16_66785084_66785300 0.01 DYNC1LI2
dynein, cytoplasmic 1, light intermediate chain 2
305
0.86
chr17_18086808_18086984 0.01 ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
504
0.6
chr2_92027935_92028159 0.01 IGKV1OR-1
immunoglobulin kappa variable 1/OR-1 (pseudogene)
22065
0.23
chr19_47951006_47951312 0.01 SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
23961
0.12
chr1_64059512_64060140 0.01 PGM1
phosphoglucomutase 1
346
0.87

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of CREB1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0050651 dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0 0.1 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0 0.1 GO:0097576 vacuole fusion(GO:0097576)
0.0 0.1 GO:0008354 germ cell migration(GO:0008354)
0.0 0.1 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.0 0.0 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.1 GO:0046655 folic acid metabolic process(GO:0046655)
0.0 0.0 GO:0031936 negative regulation of chromatin silencing(GO:0031936)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.1 GO:0008518 reduced folate carrier activity(GO:0008518)
0.0 0.1 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.0 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.0 GO:0005030 neurotrophin receptor activity(GO:0005030)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1