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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for CREB3L2

Z-value: 0.95

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Transcription factors associated with CREB3L2

Gene Symbol	Gene ID	Gene Info
CREB3L2 Ensembl NCBI GeneCards UniProt	ENSG00000182158.10	CREB3L2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
CREB3L2	chr7_137671037_137671188	15681	0.188074	0.93	2.7e-04	Click!
CREB3L2	chr7_137683078_137683229	3640	0.246252	0.68	4.4e-02	Click!
CREB3L2	chr7_137665787_137665938	20931	0.177026	0.67	5.0e-02	Click!
CREB3L2	chr7_137671468_137671947	15086	0.189262	0.61	7.9e-02	Click!
CREB3L2	chr7_137685974_137686842	385	0.868788	0.59	9.6e-02	Click!

Activity of the CREB3L2 motif across conditions

Conditions sorted by the z-value of the CREB3L2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr13_102106282_102106433	0.52	ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)	1339	0.56
chr2_151337593_151337891	0.40	RND3	Rho family GTPase 3	4154	0.38
chr2_234176635_234176786	0.35	ENSG00000252010	.	7663	0.14
chr2_27341761_27341954	0.34	CGREF1	cell growth regulator with EF-hand domain 1	41	0.94
chr3_19988451_19988692	0.34	RAB5A	RAB5A, member RAS oncogene family	0	0.54
chr1_118728319_118728470	0.34	SPAG17	sperm associated antigen 17	548	0.86
chr13_24211833_24211984	0.34	TNFRSF19	tumor necrosis factor receptor superfamily, member 19	58389	0.14
chr3_29376770_29376984	0.33	ENSG00000216169	.	34035	0.18
chr15_96952055_96952206	0.33	AC087477.1	Uncharacterized protein	47643	0.13
chr9_95970167_95970323	0.33	WNK2	WNK lysine deficient protein kinase 2	23020	0.19
chr5_178770702_178770853	0.32	ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	1654	0.49
chr22_44222171_44222754	0.32	RP3-388M5.9		14089	0.16
chr3_123602332_123603013	0.31	MYLK	myosin light chain kinase	477	0.85
chr17_47210248_47210565	0.31	B4GALNT2	beta-1,4-N-acetyl-galactosaminyl transferase 2	77	0.97
chr5_114795809_114796168	0.30	FEM1C	fem-1 homolog c (C. elegans)	84603	0.08
chr4_120987081_120987232	0.30	RP11-679C8.2		957	0.45
chr12_2185524_2185819	0.30	CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	22942	0.16
chr12_105476938_105477089	0.30	ALDH1L2	aldehyde dehydrogenase 1 family, member L2	1328	0.39
chr15_41575867_41576018	0.30	CHP1	calcineurin-like EF-hand protein 1	26834	0.13
chr6_107816329_107816751	0.29	SOBP	sine oculis binding protein homolog (Drosophila)	5378	0.23
chr2_25934983_25935152	0.29	ENSG00000222070	.	9994	0.19
chr10_119303143_119303333	0.29	EMX2	empty spiracles homeobox 2	729	0.61
chr5_154070973_154071336	0.28	ENSG00000221552	.	5818	0.17
chr2_241496900_241497119	0.27	ANKMY1	ankyrin repeat and MYND domain containing 1	370	0.78
chrY_15864765_15864916	0.27	KALP	Kallmann syndrome sequence pseudogene	1304	0.55
chrX_129245775_129245926	0.27	ELF4	E74-like factor 4 (ets domain transcription factor)	1159	0.52
chr22_28181066_28181439	0.27	MN1	meningioma (disrupted in balanced translocation) 1	16234	0.25
chr11_69460305_69460629	0.26	CCND1	cyclin D1	4493	0.24
chr6_134211072_134211606	0.26	TCF21	transcription factor 21	866	0.5
chr4_15481095_15481291	0.25	CC2D2A	coiled-coil and C2 domain containing 2A	346	0.89
chr6_147235316_147235787	0.25	STXBP5-AS1	STXBP5 antisense RNA 1	1470	0.57
chr8_17193981_17194132	0.25	MTMR7	myotubularin related protein 7	24874	0.21
chr9_131006944_131007312	0.25	ENSG00000207581	.	19	0.68
chr10_5617288_5617517	0.24	CALML3-AS1	CALML3 antisense RNA 1	49193	0.09
chr16_28213590_28213741	0.24	XPO6	exportin 6	9132	0.18
chr4_157890038_157890662	0.23	PDGFC	platelet derived growth factor C	1705	0.41
chr10_79261419_79261649	0.23	ENSG00000199592	.	85273	0.09
chr2_238316542_238316753	0.23	COL6A3	collagen, type VI, alpha 3	6144	0.22
chr3_58037164_58037339	0.23	FLNB	filamin B, beta	26805	0.22
chr21_46476184_46476390	0.22	AP001579.1	Uncharacterized protein	16640	0.14
chr20_19956104_19956326	0.22	NAA20	N(alpha)-acetyltransferase 20, NatB catalytic subunit	41545	0.15
chr12_77257769_77258091	0.22	RP11-461F16.3		14043	0.22
chr3_30722457_30722608	0.22	RP11-1024P17.1		16621	0.27
chr20_22559380_22559531	0.22	FOXA2	forkhead box A2	5646	0.34
chr17_39472322_39472473	0.22	KRTAP17-1	keratin associated protein 17-1	450	0.64
chr15_29396229_29396380	0.21	APBA2	amyloid beta (A4) precursor protein-binding, family A, member 2	59777	0.14
chr15_101629242_101629566	0.21	RP11-505E24.2		3133	0.3
chr6_7910547_7910822	0.21	TXNDC5	thioredoxin domain containing 5 (endoplasmic reticulum)	363	0.93
chr9_126088906_126089175	0.21	CRB2	crumbs homolog 2 (Drosophila)	29409	0.19
chr20_50720613_50721041	0.21	ZFP64	ZFP64 zinc finger protein	562	0.86
chr10_128076215_128076453	0.21	ADAM12	ADAM metallopeptidase domain 12	690	0.79
chr3_100708920_100709071	0.21	ABI3BP	ABI family, member 3 (NESH) binding protein	3302	0.32
chr1_55792590_55792741	0.20	ENSG00000199831	.	49860	0.14
chr1_11791745_11791900	0.20	AGTRAP	angiotensin II receptor-associated protein	4319	0.14
chr1_15653496_15653771	0.20	RP3-467K16.7		8327	0.16
chr3_131221719_131221870	0.20	MRPL3	mitochondrial ribosomal protein L3	1	0.98
chr13_52377985_52378296	0.20	DHRS12	dehydrogenase/reductase (SDR family) member 12	94	0.76
chr5_159214342_159214493	0.19	ADRA1B	adrenoceptor alpha 1B	129373	0.05
chr11_118691288_118691439	0.19	ENSG00000201535	.	15356	0.12
chr7_80928308_80928745	0.19	AC005008.2	Uncharacterized protein	111420	0.08
chr4_18023348_18023557	0.19	LCORL	ligand dependent nuclear receptor corepressor-like	31	0.99
chr6_169475368_169475519	0.19	XXyac-YX65C7_A.2		137906	0.05
chr3_183878422_183878793	0.19	DVL3	dishevelled segment polarity protein 3	4044	0.12
chrX_139847263_139847516	0.19	CDR1	cerebellar degeneration-related protein 1, 34kDa	19334	0.22
chr1_65400046_65400380	0.19	JAK1	Janus kinase 1	31974	0.2
chr7_100815791_100816003	0.19	NAT16	N-acetyltransferase 16 (GCN5-related, putative)	6620	0.1
chr1_247495331_247495594	0.19	ZNF496	zinc finger protein 496	417	0.84
chr6_168558891_168559173	0.19	FRMD1	FERM domain containing 1	76795	0.11
chr16_89368321_89368642	0.18	AC137932.5		4217	0.15
chr3_169490145_169490517	0.18	MYNN	myoneurin	288	0.79
chr19_35581704_35581880	0.18	AC020907.1	Uncharacterized protein	15081	0.09
chr7_116732017_116732168	0.18	ST7-AS2	ST7 antisense RNA 2	1258	0.49
chr3_184078420_184078571	0.18	CLCN2	chloride channel, voltage-sensitive 2	895	0.31
chr9_137437911_137438062	0.18	COL5A1	collagen, type V, alpha 1	95634	0.07
chr17_33307453_33307681	0.18	LIG3	ligase III, DNA, ATP-dependent	2	0.9
chr4_48492552_48492703	0.18	ZAR1	zygote arrest 1	358	0.88
chr14_73357781_73357932	0.18	DPF3	D4, zinc and double PHD fingers, family 3	2940	0.24
chr10_100993963_100995023	0.18	HPSE2	heparanase 2	1066	0.66
chr7_129194061_129194212	0.18	SMKR1	small lysine-rich protein 1	51503	0.12
chr6_43970266_43970484	0.17	RP5-1120P11.1		1011	0.46
chr18_52969288_52969439	0.17	TCF4	transcription factor 4	494	0.88
chr15_34788505_34788693	0.17	ENSG00000221065	.	31973	0.15
chr17_38599985_38600404	0.17	IGFBP4	insulin-like growth factor binding protein 4	481	0.74
chr17_18061433_18061699	0.17	MYO15A	myosin XVA	56	0.96
chr15_77713527_77713880	0.17	HMG20A	high mobility group 20A	350	0.83
chr11_3077193_3077344	0.17	CARS	cysteinyl-tRNA synthetase	1364	0.33
chr4_3306467_3306618	0.17	RGS12	regulator of G-protein signaling 12	4220	0.28
chr6_18122528_18122892	0.17	NHLRC1	NHL repeat containing E3 ubiquitin protein ligase 1	141	0.96
chr12_49318526_49318771	0.17	FKBP11	FK506 binding protein 11, 19 kDa	102	0.91
chr9_19493377_19493724	0.17	RP11-363E7.4		40343	0.16
chr12_120755596_120755815	0.17	ENSG00000252659	.	4561	0.12
chr2_198243514_198243752	0.17	SF3B1	splicing factor 3b, subunit 1, 155kDa	20119	0.14
chr7_100200956_100201118	0.17	PCOLCE-AS1	PCOLCE antisense RNA 1	379	0.65
chr6_39760880_39761039	0.17	DAAM2	dishevelled associated activator of morphogenesis 2	165	0.97
chr17_66379730_66379881	0.16	ENSG00000207561	.	40884	0.14
chr2_217497534_217497685	0.16	IGFBP2	insulin-like growth factor binding protein 2, 36kDa	58	0.97
chrX_55187773_55187985	0.16	FAM104B	family with sequence similarity 104, member B	136	0.96
chr7_23145115_23145340	0.16	KLHL7	kelch-like family member 7	126	0.97
chr15_96877570_96877721	0.16	ENSG00000222651	.	1155	0.34
chr12_12447841_12447992	0.16	ENSG00000207010	.	5653	0.19
chr17_29887977_29888214	0.16	ENSG00000207614	.	1080	0.35
chr11_63774609_63774760	0.16	OTUB1	OTU domain, ubiquitin aldehyde binding 1	20370	0.1
chr16_88450130_88450579	0.16	ZNF469	zinc finger protein 469	43525	0.15
chr8_70668894_70669045	0.16	RP11-102F4.2		43344	0.14
chr11_3043840_3044115	0.16	CARS-AS1	CARS antisense RNA 1	6647	0.13
chr19_47447845_47447996	0.16	ENSG00000252071	.	3626	0.22
chr13_34361275_34361581	0.16	RFC3	replication factor C (activator 1) 3, 38kDa	30758	0.21
chr9_103494116_103494267	0.16	ENSG00000200966	.	150530	0.04
chr17_38603034_38603205	0.16	IGFBP4	insulin-like growth factor binding protein 4	3406	0.18
chrX_17394886_17395095	0.16	NHS	Nance-Horan syndrome (congenital cataracts and dental anomalies)	1447	0.46
chr6_7672816_7672976	0.16	BMP6	bone morphogenetic protein 6	54134	0.14
chr3_37493102_37493470	0.16	ITGA9	integrin, alpha 9	320	0.92
chr5_179518071_179518222	0.16	RNF130	ring finger protein 130	19028	0.19
chr19_51227387_51227538	0.15	CLEC11A	C-type lectin domain family 11, member A	682	0.53
chr3_178789075_178789341	0.15	ZMAT3	zinc finger, matrin-type 3	146	0.96
chr14_99848474_99848625	0.15	ENSG00000216173	.	19921	0.19
chr22_28174315_28174484	0.15	MN1	meningioma (disrupted in balanced translocation) 1	23087	0.23
chr6_52422559_52422710	0.15	TRAM2	translocation associated membrane protein 2	19079	0.23
chr17_1081882_1082496	0.15	ABR	active BCR-related	889	0.58
chr11_94502592_94502995	0.15	AMOTL1	angiomotin like 1	1256	0.53
chr1_2231502_2231862	0.15	RP4-713A8.1		26450	0.11
chr6_137144069_137144462	0.15	PEX7	peroxisomal biogenesis factor 7	542	0.78
chr9_126110255_126110406	0.15	CRB2	crumbs homolog 2 (Drosophila)	8119	0.24
chr7_101579659_101580126	0.15	CTB-181H17.1		23504	0.22
chr1_28919066_28919537	0.15	RAB42	RAB42, member RAS oncogene family	589	0.62
chr19_41193747_41193898	0.15	NUMBL	numb homolog (Drosophila)-like	1675	0.25
chr6_52437991_52438235	0.15	TRAM2	translocation associated membrane protein 2	3600	0.31
chr22_36902639_36903091	0.14	FOXRED2	FAD-dependent oxidoreductase domain containing 2	204	0.92
chr17_80008374_80008525	0.14	GPS1	G protein pathway suppressor 1	375	0.59
chr21_36935983_36936169	0.14	ENSG00000211590	.	156937	0.04
chr1_244014741_244014953	0.14	AKT3	v-akt murine thymoma viral oncogene homolog 3	466	0.87
chr19_45826969_45827349	0.14	CKM	creatine kinase, muscle	924	0.44
chr2_242626487_242626967	0.14	DTYMK	deoxythymidylate kinase (thymidylate kinase)	321	0.79
chr12_110010896_110011058	0.14	MVK	mevalonate kinase	83	0.79
chr10_74114795_74115085	0.14	DNAJB12	DnaJ (Hsp40) homolog, subfamily B, member 12	33	0.98
chr2_232328586_232328818	0.14	NCL	nucleolin	189	0.89
chr12_109901272_109901510	0.14	KCTD10	potassium channel tetramerization domain containing 10	3191	0.21
chr12_133613669_133614058	0.14	ZNF84	zinc finger protein 84	15	0.97
chr15_90645383_90645632	0.14	IDH2	isocitrate dehydrogenase 2 (NADP+), mitochondrial	193	0.92
chr6_110720825_110721164	0.14	DDO	D-aspartate oxidase	15771	0.18
chr1_57890417_57890605	0.14	DAB1	Dab, reelin signal transducer, homolog 1 (Drosophila)	782	0.79
chr17_18537909_18538132	0.14	TBC1D28	TBC1 domain family, member 28	7717	0.13
chr1_202896403_202896578	0.14	KLHL12	kelch-like family member 12	100	0.95
chr3_39190203_39190389	0.14	CSRNP1	cysteine-serine-rich nuclear protein 1	4770	0.2
chr19_41111211_41111409	0.14	ENSG00000266164	.	1645	0.28
chr16_70148022_70148173	0.14	PDPR	pyruvate dehydrogenase phosphatase regulatory subunit	178	0.94
chr16_28985699_28985940	0.14	SPNS1	spinster homolog 1 (Drosophila)	177	0.87
chr6_136871727_136872192	0.13	MAP7	microtubule-associated protein 7	2	0.67
chr3_49940383_49940534	0.13	MST1R	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	584	0.48
chrX_52964541_52964769	0.13	FAM156A	family with sequence similarity 156, member A	20874	0.17
chr9_82278752_82279150	0.13	TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	11443	0.33
chr3_148709208_148709359	0.13	GYG1	glycogenin 1	16	0.98
chr3_9958820_9959089	0.13	IL17RC	interleukin 17 receptor C	46	0.93
chr12_65959878_65960118	0.13	MSRB3	methionine sulfoxide reductase B3	239343	0.02
chr6_161664088_161664497	0.13	AGPAT4	1-acylglycerol-3-phosphate O-acyltransferase 4	30759	0.25
chr18_59537327_59537518	0.13	RNF152	ring finger protein 152	23570	0.27
chrX_17395110_17395408	0.13	NHS	Nance-Horan syndrome (congenital cataracts and dental anomalies)	1716	0.4
chr6_31802720_31802923	0.13	C6orf48	chromosome 6 open reading frame 48	112	0.61
chr19_44007928_44008284	0.13	PHLDB3	pleckstrin homology-like domain, family B, member 3	460	0.71
chr17_20812306_20812457	0.13	RP11-344E13.3		11977	0.13
chr1_150254993_150255622	0.13	C1orf51	chromosome 1 open reading frame 51	78	0.94
chr18_158238_158410	0.13	USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	59	0.98
chr18_53398919_53399070	0.13	TCF4	transcription factor 4	66976	0.14
chr2_242823909_242824060	0.13	AC131097.3		115	0.94
chr21_47038314_47038465	0.13	PCBP3	poly(rC) binding protein 3	25219	0.21
chr13_97992448_97992599	0.13	MBNL2	muscleblind-like splicing regulator 2	16527	0.22
chr3_192289269_192289452	0.13	ENSG00000238902	.	37459	0.17
chr1_68297532_68297957	0.13	GNG12-AS1	GNG12 antisense RNA 1	242	0.9
chrX_292077_292313	0.13	LINC00685	long intergenic non-protein coding RNA 685	10470	0.23
chr3_61668665_61668816	0.13	ENSG00000252420	.	56163	0.17
chr10_76994278_76994482	0.13	COMTD1	catechol-O-methyltransferase domain containing 1	1303	0.47
chr9_46168304_46168455	0.13	ENSG00000238413	.	26704	0.23
chr5_91833_92077	0.13	PLEKHG4B	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	48418	0.13
chr14_76446267_76446546	0.13	TGFB3	transforming growth factor, beta 3	930	0.62
chr8_80681214_80681467	0.13	HEY1	hes-related family bHLH transcription factor with YRPW motif 1	1242	0.56
chr19_35939103_35939363	0.13	FFAR2	free fatty acid receptor 2	30	0.96
chr16_839466_839674	0.13	CHTF18	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	257	0.75
chr8_1771644_1772131	0.13	ARHGEF10	Rho guanine nucleotide exchange factor (GEF) 10	255	0.93
chr14_26994857_26995008	0.13	RP11-483C6.1		68791	0.11
chr3_72091935_72092086	0.12	ENSG00000239250	.	215682	0.02
chr1_214397865_214398571	0.12	SMYD2	SET and MYND domain containing 2	56358	0.16
chr20_25208343_25208494	0.12	AL035252.1	HCG2018895; Uncharacterized protein	1048	0.47
chrX_129039705_129039949	0.12	UTP14A	UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)	270	0.92
chr3_42697942_42698093	0.12	RP4-613B23.1		2137	0.17
chrX_56790465_56790994	0.12	ENSG00000204272	.	35037	0.23
chr11_79718516_79718667	0.12	ENSG00000221551	.	315168	0.01
chr7_5637609_5637772	0.12	FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	3373	0.21
chr6_133562382_133562833	0.12	EYA4	eyes absent homolog 4 (Drosophila)	51	0.99
chr19_2783530_2783806	0.12	SGTA	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	299	0.8
chr7_150065813_150066064	0.12	REPIN1	replication initiator 1	22	0.52
chr17_49230988_49231211	0.12	NME1	NME/NM23 nucleoside diphosphate kinase 1	73	0.37
chr10_126359460_126359611	0.12	FAM53B-AS1	FAM53B antisense RNA 1	32659	0.18
chr3_30691423_30691574	0.12	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	43405	0.18
chr8_143782547_143782698	0.12	LY6K	lymphocyte antigen 6 complex, locus K	732	0.49
chr22_30641304_30641455	0.12	RP1-102K2.8		605	0.52
chr8_122652196_122652655	0.12	HAS2-AS1	HAS2 antisense RNA 1	283	0.88
chr8_102121369_102121647	0.12	ENSG00000202360	.	28679	0.21
chr5_141257083_141257234	0.12	PCDH1	protocadherin 1	796	0.64
chr5_118733448_118733675	0.12	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	41831	0.13
chr4_20256302_20256578	0.12	SLIT2	slit homolog 2 (Drosophila)	103	0.98

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of CREB3L2

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1	0.2	GO:0021542	dentate gyrus development(GO:0021542)
0.1	0.2	GO:0046940	nucleoside monophosphate phosphorylation(GO:0046940)
0.0	0.1	GO:0061364	apoptotic process involved in luteolysis(GO:0061364)
0.0	0.1	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.1	GO:0090266	positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.0	0.1	GO:0033345	asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.0	0.2	GO:0009109	coenzyme catabolic process(GO:0009109)
0.0	0.2	GO:0006546	glycine catabolic process(GO:0006546)
0.0	0.1	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0034723	DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.1	GO:0032025	response to cobalt ion(GO:0032025)
0.0	0.2	GO:0051103	DNA ligation involved in DNA repair(GO:0051103)
0.0	0.1	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.1	GO:0006102	isocitrate metabolic process(GO:0006102)
0.0	0.1	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.1	GO:0022010	central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0	0.1	GO:0042637	catagen(GO:0042637)
0.0	0.0	GO:0043589	skin morphogenesis(GO:0043589)
0.0	0.3	GO:0048745	smooth muscle tissue development(GO:0048745)
0.0	0.1	GO:0034227	tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) tRNA thio-modification(GO:0034227)
0.0	0.1	GO:0046520	sphingoid biosynthetic process(GO:0046520)
0.0	0.1	GO:0046504	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.3	GO:0006662	glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.0	0.1	GO:0015820	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0	0.1	GO:0016081	synaptic vesicle docking(GO:0016081)
0.0	0.1	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0	0.1	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.1	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0	0.1	GO:0033567	DNA replication, Okazaki fragment processing(GO:0033567) DNA replication, removal of RNA primer(GO:0043137)
0.0	0.1	GO:0009103	lipopolysaccharide biosynthetic process(GO:0009103)
0.0	0.1	GO:0070141	response to UV-A(GO:0070141)
0.0	0.0	GO:0007638	mechanosensory behavior(GO:0007638)
0.0	0.1	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0	0.0	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.1	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.0	GO:0003148	outflow tract septum morphogenesis(GO:0003148)
0.0	0.1	GO:0008218	bioluminescence(GO:0008218)
0.0	0.0	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.1	GO:0006621	protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0	0.1	GO:0048207	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0	0.0	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	0.0	GO:0015801	aromatic amino acid transport(GO:0015801)
0.0	0.0	GO:0072112	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.2	GO:0048169	regulation of long-term neuronal synaptic plasticity(GO:0048169)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.0	GO:0051138	NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0	0.0	GO:0060463	lung lobe development(GO:0060462) lung lobe morphogenesis(GO:0060463)
0.0	0.0	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0	0.0	GO:0032906	transforming growth factor beta2 production(GO:0032906) regulation of transforming growth factor beta2 production(GO:0032909)
0.0	0.1	GO:0006853	carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603)
0.0	0.2	GO:0018208	peptidyl-proline modification(GO:0018208)
0.0	0.1	GO:0050427	purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0	0.2	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0	0.0	GO:0070857	regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.0	0.1	GO:0034285	response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.0	0.1	GO:0021873	forebrain neuroblast division(GO:0021873)
0.0	0.0	GO:0002606	positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0	0.0	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.1	GO:0046051	GTP biosynthetic process(GO:0006183) UTP biosynthetic process(GO:0006228) CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036) UTP metabolic process(GO:0046051)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.1	GO:0017059	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.2	GO:0042589	zymogen granule membrane(GO:0042589)
0.2	GO:0032040	small-subunit processome(GO:0032040)
0.2	GO:0043202	lysosomal lumen(GO:0043202)
0.1	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.2	GO:0008180	COP9 signalosome(GO:0008180)
0.1	GO:0070695	FHF complex(GO:0070695)
0.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.3	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1	GO:0016342	catenin complex(GO:0016342)
0.4	GO:0008305	integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.3	GO:0019861	obsolete flagellum(GO:0019861)
0.1	GO:0042575	DNA polymerase complex(GO:0042575)
0.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.1	GO:0014704	intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0	GO:0005638	lamin filament(GO:0005638)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.1	0.2	GO:0001159	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.1	0.2	GO:0003909	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1	0.2	GO:0031177	phosphopantetheine binding(GO:0031177)
0.0	0.1	GO:0008192	RNA guanylyltransferase activity(GO:0008192)
0.0	0.2	GO:0004047	aminomethyltransferase activity(GO:0004047)
0.0	0.2	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.1	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0016454	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.2	GO:0005536	glucose binding(GO:0005536)
0.0	0.2	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.0	0.2	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.1	GO:0004448	isocitrate dehydrogenase activity(GO:0004448)
0.0	0.1	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.1	GO:0046923	ER retention sequence binding(GO:0046923)
0.0	0.1	GO:0005113	patched binding(GO:0005113)
0.0	0.1	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.1	GO:0042285	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.1	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.1	GO:0016416	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0	0.1	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.1	GO:0017108	5'-flap endonuclease activity(GO:0017108)
0.0	0.0	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.1	GO:0019855	calcium channel inhibitor activity(GO:0019855)
0.0	0.1	GO:0004111	creatine kinase activity(GO:0004111)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.3	GO:0015035	protein disulfide oxidoreductase activity(GO:0015035)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.0	GO:0005534	galactose binding(GO:0005534)
0.0	0.1	GO:0016417	S-acyltransferase activity(GO:0016417)
0.0	0.2	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.0	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.1	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.2	GO:0042162	telomeric DNA binding(GO:0042162)
0.0	0.1	GO:0016783	sulfurtransferase activity(GO:0016783)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.2	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.0	0.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.0	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.0	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.0	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0	0.0	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.1	GO:0008121	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0	0.0	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.0	GO:0031628	opioid receptor binding(GO:0031628)
0.0	0.3	GO:0008376	acetylgalactosaminyltransferase activity(GO:0008376)
0.0	0.1	GO:0004550	nucleoside diphosphate kinase activity(GO:0004550)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.5	PID AURORA B PATHWAY	Aurora B signaling
0.3	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.3	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.3	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.1	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism