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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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Results for CREB5_CREM_JUNB

Z-value: 0.60

Motif logo

Transcription factors associated with CREB5_CREM_JUNB

Gene Symbol	Gene ID	Gene Info
CREB5 Ensembl NCBI GeneCards UniProt	ENSG00000146592.12	cAMP responsive element binding protein 5
CREM Ensembl NCBI GeneCards UniProt	ENSG00000095794.15	cAMP responsive element modulator
JUNB Ensembl NCBI GeneCards UniProt	ENSG00000171223.4	JunB proto-oncogene, AP-1 transcription factor subunit

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr7_28831481_28831632	CREB5	17470	0.283213	0.83	6.1e-03	Click!
chr7_28527889_28528184	CREB5	2712	0.426629	0.74	2.2e-02	Click!
chr7_28520636_28520787	CREB5	10037	0.317780	-0.73	2.5e-02	Click!
chr7_28893641_28893920	CREB5	44754	0.182738	0.68	4.5e-02	Click!
chr7_28705588_28705739	CREB5	19935	0.287766	0.65	5.8e-02	Click!
chr10_35473384_35473535	CREM	8828	0.152255	-0.58	1.0e-01	Click!
chr10_35415781_35416197	CREM	30	0.501216	0.56	1.2e-01	Click!
chr10_35416363_35416802	CREM	177	0.833617	0.43	2.4e-01	Click!
chr10_35484694_35485080	CREM	42	0.968921	0.40	2.8e-01	Click!
chr10_35454329_35454480	CREM	2040	0.267658	0.35	3.5e-01	Click!
chr19_12902481_12903520	JUNB	690	0.389467	0.84	5.0e-03	Click!
chr19_12899780_12900482	JUNB	2179	0.106758	0.83	5.5e-03	Click!
chr19_12903915_12904171	JUNB	1733	0.135908	0.55	1.2e-01	Click!
chr19_12903527_12903836	JUNB	1371	0.175965	0.52	1.5e-01	Click!
chr19_12901610_12901988	JUNB	511	0.517306	0.25	5.1e-01	Click!

Activity of the CREB5_CREM_JUNB motif across conditions

Conditions sorted by the z-value of the CREB5_CREM_JUNB motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr8_21967077_21967500	0.39	NUDT18	nudix (nucleoside diphosphate linked moiety X)-type motif 18	356	0.79
chr20_16926810_16926961	0.37	ENSG00000212165	.	36793	0.22
chr5_176881613_176881764	0.35	PRR7	proline rich 7 (synaptic)	6353	0.1
chr5_170739718_170739894	0.34	TLX3	T-cell leukemia homeobox 3	3518	0.22
chr4_15721295_15721446	0.31	BST1	bone marrow stromal cell antigen 1	4419	0.23
chr12_56521312_56521715	0.30	ESYT1	extended synaptotagmin-like protein 1	327	0.64
chr19_8454704_8454922	0.30	RAB11B	RAB11B, member RAS oncogene family	52	0.65
chr17_4046800_4047053	0.30	CYB5D2	cytochrome b5 domain containing 2	70	0.9
chr19_17666323_17666474	0.27	COLGALT1	collagen beta(1-O)galactosyltransferase 1	5	0.96
chr6_91006489_91006667	0.26	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2	49	0.98
chr7_100808865_100809016	0.26	VGF	VGF nerve growth factor inducible	66	0.94
chr15_59658629_59658780	0.26	FAM81A	family with sequence similarity 81, member A	6188	0.13
chr16_86817661_86817812	0.26	FOXL1	forkhead box L1	205621	0.02
chr2_8144573_8144775	0.24	ENSG00000221255	.	427702	0.01
chr2_28582064_28582304	0.24	FOSL2	FOS-like antigen 2	33485	0.14
chr19_46009815_46010009	0.23	VASP	vasodilator-stimulated phosphoprotein	75	0.95
chr12_71833497_71833776	0.22	LGR5	leucine-rich repeat containing G protein-coupled receptor 5	86	0.97
chr1_228356433_228356584	0.22	IBA57	IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)	2992	0.14
chr9_130860266_130860759	0.22	SLC25A25	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25	71	0.93
chr12_54378782_54378933	0.21	HOXC10	homeobox C10	8	0.71
chr17_2496882_2497033	0.21	PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	83	0.97
chr9_137347969_137348661	0.20	RXRA	retinoid X receptor, alpha	49887	0.15
chr11_18720267_18720541	0.20	TMEM86A	transmembrane protein 86A	66	0.96
chr19_42900892_42901243	0.19	LIPE-AS1	LIPE antisense RNA 1	213	0.88
chr3_170075366_170075517	0.19	SKIL	SKI-like oncogene	62	0.98
chr1_228353838_228353989	0.19	IBA57	IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)	397	0.6
chr11_64044573_64044724	0.19	GPR137	G protein-coupled receptor 137	1488	0.15
chr17_6926858_6927139	0.18	BCL6B	B-cell CLL/lymphoma 6, member B	202	0.83
chr7_27232397_27232921	0.18	HOXA11-AS	HOXA11 antisense RNA	5221	0.07
chr6_108486676_108487297	0.18	OSTM1	osteopetrosis associated transmembrane protein 1	58	0.78
chr19_55919228_55919426	0.18	UBE2S	ubiquitin-conjugating enzyme E2S	182	0.86
chr4_159131007_159131158	0.17	TMEM144	transmembrane protein 144	264	0.91
chr1_155292308_155292690	0.17	RUSC1-AS1	RUSC1 antisense RNA 1	1164	0.22
chr7_96634662_96635012	0.17	DLX6	distal-less homeobox 6	23	0.95
chr17_7165860_7166195	0.17	CLDN7	claudin 7	230	0.78
chr20_19915434_19915955	0.16	RIN2	Ras and Rab interactor 2	45484	0.16
chr8_145555468_145555619	0.16	SCRT1	scratch family zinc finger 1	4400	0.08
chr20_34203605_34204165	0.16	SPAG4	sperm associated antigen 4	71	0.95
chr6_3157575_3157860	0.16	TUBB2A	tubulin, beta 2A class IIa	43	0.97
chr5_58423468_58424016	0.16	RP11-266N13.2		88154	0.09
chr7_38217813_38218059	0.16	STARD3NL	STARD3 N-terminal like	17	0.99
chr19_55574631_55574782	0.16	RDH13	retinol dehydrogenase 13 (all-trans/9-cis)	162	0.91
chr20_15773685_15773836	0.15	MACROD2	MACRO domain containing 2	69690	0.14
chr19_10974082_10974233	0.15	CARM1	coactivator-associated arginine methyltransferase 1	8032	0.12
chr16_27378896_27379134	0.15	IL4R	interleukin 4 receptor	15019	0.19
chr2_74781498_74781793	0.15	DOK1	docking protein 1, 62kDa (downstream of tyrosine kinase 1)	213	0.73
chr16_12086577_12086728	0.15	RP11-166B2.7		14945	0.11
chr19_51014778_51015051	0.15	JOSD2	Josephin domain containing 2	304	0.8
chr17_18528902_18529084	0.14	CCDC144B	coiled-coil domain containing 144B (pseudogene)	72	0.96
chr19_45349520_45349839	0.14	PVRL2	poliovirus receptor-related 2 (herpesvirus entry mediator B)	104	0.94
chr16_31471330_31471687	0.14	ARMC5	armadillo repeat containing 5	226	0.67
chr3_29228940_29229091	0.14	RBMS3	RNA binding motif, single stranded interacting protein 3	93458	0.09
chr2_43822335_43823890	0.14	THADA	thyroid adenoma associated	1	0.98
chr6_158508116_158508267	0.13	SYNJ2	synaptojanin 2	9479	0.2
chr14_74352825_74353319	0.13	ZNF410	zinc finger protein 410	248	0.86
chr9_137263893_137264044	0.13	ENSG00000263897	.	7289	0.25
chr16_85045097_85045598	0.13	ZDHHC7	zinc finger, DHHC-type containing 7	206	0.95
chr19_2956542_2956693	0.13	ZNF77	zinc finger protein 77	11686	0.12
chr2_179278488_179279091	0.13	AC009948.5		39	0.97
chr4_186316826_186317184	0.12	LRP2BP	LRP2 binding protein	48	0.69
chr9_132250998_132251163	0.12	ENSG00000264298	.	10245	0.21
chr5_112849172_112849403	0.12	YTHDC2	YTH domain containing 2	93	0.97
chr14_55738060_55738282	0.12	FBXO34	F-box protein 34	150	0.97
chr11_14604750_14604901	0.12	PSMA1	proteasome (prosome, macropain) subunit, alpha type, 1	60338	0.12
chr10_99078775_99079092	0.12	FRAT1	frequently rearranged in advanced T-cell lymphomas	89	0.95
chr5_107005011_107005570	0.12	EFNA5	ephrin-A5	1038	0.67
chr17_4643181_4643351	0.12	CXCL16	chemokine (C-X-C motif) ligand 16	49	0.49
chr11_108535331_108535645	0.12	DDX10	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	264	0.95
chr16_88859439_88859692	0.11	PIEZO1	piezo-type mechanosensitive ion channel component 1	7946	0.09
chr7_6388445_6388661	0.11	FAM220A	family with sequence similarity 220, member A	37	0.98
chr8_135844464_135844657	0.11	ENSG00000199153	.	27372	0.21
chr3_8543267_8543418	0.11	LMCD1-AS1	LMCD1 antisense RNA 1 (head to head)	1	0.52
chr5_73730259_73730491	0.11	ENSG00000244326	.	116564	0.06
chr3_122513577_122513821	0.11	DIRC2	disrupted in renal carcinoma 2	57	0.95
chr9_35617185_35617463	0.11	CD72	CD72 molecule	1043	0.3
chr12_57855074_57855466	0.11	GLI1	GLI family zinc finger 1	996	0.31
chr16_31142045_31142196	0.11	RP11-388M20.2		634	0.42
chr14_103988458_103988873	0.11	CKB	creatine kinase, brain	368	0.73
chr22_36519910_36520146	0.11	APOL3	apolipoprotein L, 3	36803	0.17
chr10_105728102_105728505	0.10	SLK	STE20-like kinase	1344	0.4
chr1_63787954_63788471	0.10	RP4-792G4.2		83	0.88
chr18_74205501_74206173	0.10	ZNF516	zinc finger protein 516	1309	0.32
chr22_51059513_51059819	0.10	ARSA	arylsulfatase A	6917	0.1
chr18_2654684_2655529	0.10	SMCHD1	structural maintenance of chromosomes flexible hinge domain containing 1	631	0.67
chr17_79093601_79093928	0.10	ENSG00000207736	.	5409	0.1
chr21_44597084_44597458	0.10	CRYAA	crystallin, alpha A	7005	0.17
chr8_33422545_33422696	0.10	RNF122	ring finger protein 122	2023	0.25
chr8_13129460_13129611	0.10	DLC1	deleted in liver cancer 1	4520	0.3
chr2_78182087_78182238	0.10	LRRTM4	leucine rich repeat transmembrane neuronal 4	361840	0.01
chr7_993167_993948	0.10	ADAP1	ArfGAP with dual PH domains 1	776	0.55
chr12_7282858_7283009	0.10	RP11-273B20.1		85	0.56
chr3_33759550_33759763	0.10	CLASP2	cytoplasmic linker associated protein 2	115	0.98
chr14_69260124_69260503	0.10	ZFP36L1	ZFP36 ring finger protein-like 1	356	0.9
chr17_55333458_55333748	0.10	MSI2	musashi RNA-binding protein 2	292	0.94
chr10_33798417_33798757	0.09	NRP1	neuropilin 1	173397	0.03
chr17_41281855_41282006	0.09	NBR2	neighbor of BRCA1 gene 2 (non-protein coding)	1295	0.35
chr2_64957643_64958616	0.09	ENSG00000253082	.	45109	0.14
chr12_7068434_7068709	0.09	ENSG00000207713	.	4291	0.07
chr17_19367994_19368145	0.09	ENSG00000265335	.	44477	0.09
chr9_133788553_133789184	0.09	FIBCD1	fibrinogen C domain containing 1	16498	0.16
chr14_71353925_71354621	0.09	PCNX	pecanex homolog (Drosophila)	19849	0.26
chr21_45209367_45209684	0.08	RRP1	ribosomal RNA processing 1	131	0.95
chr20_56284812_56285148	0.08	PMEPA1	prostate transmembrane protein, androgen induced 1	22	0.99
chr11_1404301_1404651	0.08	BRSK2	BR serine/threonine kinase 2	6653	0.2
chr17_1953560_1953783	0.08	ENSG00000267195	.	3	0.83
chr22_42228451_42228869	0.08	SREBF2	sterol regulatory element binding transcription factor 2	449	0.71
chr4_37686725_37687086	0.08	RELL1	RELT-like 1	1093	0.57
chr1_155164087_155164666	0.08	ENSG00000271748	.	592	0.39
chr19_54960345_54960655	0.08	LENG8	leukocyte receptor cluster (LRC) member 8	94	0.72
chr1_17630726_17630943	0.08	PADI4	peptidyl arginine deiminase, type IV	3856	0.2
chr3_52321810_52322234	0.08	WDR82	WD repeat domain 82	14	0.64
chr10_16870022_16870173	0.08	RSU1	Ras suppressor protein 1	10570	0.28
chr10_35484694_35485080	0.08	CREM	cAMP responsive element modulator	42	0.97
chr1_29213318_29213476	0.08	EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	206	0.93
chr15_89905376_89905703	0.08	ENSG00000207819	.	5709	0.19
chr6_159519573_159519904	0.08	TAGAP	T-cell activation RhoGTPase activating protein	53554	0.11
chr2_138880085_138880236	0.08	HNMT	histamine N-methyltransferase	158117	0.04
chr20_56293559_56293931	0.07	PMEPA1	prostate transmembrane protein, androgen induced 1	7204	0.28
chr7_4764745_4765032	0.07	FOXK1	forkhead box K1	15602	0.18
chr16_67564286_67564635	0.07	FAM65A	family with sequence similarity 65, member A	766	0.44
chr11_118122819_118123419	0.07	MPZL3	myelin protein zero-like 3	54	0.96
chr20_12990547_12990774	0.07	SPTLC3	serine palmitoyltransferase, long chain base subunit 3	663	0.83
chr19_39175153_39175304	0.07	CTB-186G2.4		9018	0.12
chr11_12989815_12989966	0.07	ENSG00000266625	.	4703	0.25
chr15_70250319_70250470	0.07	ENSG00000207965	.	121413	0.06
chr22_39745318_39745552	0.07	SYNGR1	synaptogyrin 1	495	0.71
chr19_46931946_46932393	0.07	CCDC8	coiled-coil domain containing 8	15328	0.13
chr11_33183160_33183580	0.07	CSTF3-AS1	CSTF3 antisense RNA 1 (head to head)	136	0.7
chr1_91183266_91183570	0.07	BARHL2	BarH-like homeobox 2	624	0.83
chr19_1855668_1855910	0.06	CTB-31O20.6		3391	0.1
chr16_2563812_2564354	0.06	ATP6V0C	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c	106	0.49
chr12_66347998_66348149	0.06	RP11-366L20.3		5814	0.22
chr6_157007333_157008165	0.06	ARID1B	AT rich interactive domain 1B (SWI1-like)	91314	0.08
chr10_71991819_71992862	0.06	PPA1	pyrophosphatase (inorganic) 1	820	0.66
chr18_20840698_20840849	0.06	RP11-17J14.2		455	0.88
chr19_36036432_36037158	0.06	AD000090.2		136	0.59
chr11_82782830_82782981	0.06	RAB30	RAB30, member RAS oncogene family	3	0.98
chr17_17586273_17586527	0.06	RAI1	retinoic acid induced 1	591	0.75
chr7_140396423_140396944	0.06	NDUFB2	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa	105	0.63
chr8_142275255_142276084	0.06	RP11-10J21.3	Uncharacterized protein	11005	0.14
chr10_14880634_14881306	0.06	CDNF	cerebral dopamine neurotrophic factor	396	0.57
chrX_39759626_39759841	0.06	ENSG00000263972	.	62918	0.14
chr8_41605528_41605679	0.06	ANK1	ankyrin 1, erythrocytic	41906	0.13
chr3_51720796_51721049	0.06	ENSG00000201595	.	7676	0.15
chr1_28655191_28655470	0.06	MED18	mediator complex subunit 18	219	0.92
chr17_61851142_61851414	0.06	DDX42	DEAD (Asp-Glu-Ala-Asp) box helicase 42	34	0.63
chr2_190140835_190141232	0.06	ENSG00000266817	.	35454	0.2
chr8_39043803_39043954	0.06	ADAM32	ADAM metallopeptidase domain 32	78403	0.1
chr8_145561219_145561461	0.06	SCRT1	scratch family zinc finger 1	1397	0.19
chr9_100565675_100565842	0.06	FOXE1	forkhead box E1 (thyroid transcription factor 2)	49778	0.12
chr19_9546259_9546565	0.06	ZNF266	zinc finger protein 266	178	0.95
chr17_46684210_46684361	0.06	HOXB6	homeobox B6	1931	0.13
chr1_244013782_244014025	0.05	AKT3	v-akt murine thymoma viral oncogene homolog 3	473	0.87
chr4_5758904_5759055	0.05	EVC	Ellis van Creveld syndrome	46037	0.16
chr2_238609518_238609709	0.05	LRRFIP1	leucine rich repeat (in FLII) interacting protein 1	8631	0.24
chr16_81514485_81514779	0.05	CMIP	c-Maf inducing protein	14322	0.26
chr9_19472304_19472455	0.05	RP11-363E7.4		19172	0.2
chr20_17876219_17876496	0.05	ENSG00000212555	.	8049	0.2
chr13_24742029_24742180	0.05	ENSG00000252695	.	5549	0.22
chr8_142180071_142180222	0.05	DENND3	DENN/MADD domain containing 3	8074	0.2
chr3_185080934_185081796	0.05	MAP3K13	mitogen-activated protein kinase kinase kinase 13	457	0.87
chr6_47445012_47445717	0.05	CD2AP	CD2-associated protein	161	0.96
chr1_226189668_226189925	0.05	SDE2	SDE2 telomere maintenance homolog (S. pombe)	2764	0.23
chr9_99851520_99851671	0.05	CTSV	cathepsin V	49670	0.15
chr15_48858385_48858541	0.05	FBN1	fibrillin 1	79455	0.1
chr16_87469465_87469755	0.05	ZCCHC14	zinc finger, CCHC domain containing 14	2870	0.22
chr7_106064692_106064843	0.05	CTB-111H14.1		80518	0.1
chr16_68056878_68057148	0.05	DUS2	dihydrouridine synthase 2	143	0.85
chr8_38243294_38243670	0.05	LETM2	leucine zipper-EF-hand containing transmembrane protein 2	243	0.88
chr16_55401499_55401650	0.05	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	22038	0.18
chr4_174443030_174443487	0.05	HAND2-AS1	HAND2 antisense RNA 1 (head to head)	5163	0.23
chr3_50297522_50298009	0.05	SEMA3B-AS1	SEMA3B antisense RNA 1 (head to head)	7038	0.09
chr6_27862660_27863352	0.05	HIST1H2BO	histone cluster 1, H2bo	1803	0.13
chr10_30744625_30744776	0.05	MAP3K8	mitogen-activated protein kinase kinase kinase 8	16949	0.22
chr1_1490221_1490372	0.05	TMEM240	transmembrane protein 240	14463	0.09
chr19_38908689_38908861	0.05	RASGRP4	RAS guanyl releasing protein 4	8027	0.09
chr6_126660953_126661204	0.05	CENPW	centromere protein W	242	0.96
chr7_1979405_1979706	0.05	MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	630	0.8
chr12_54411200_54411679	0.05	HOXC4	homeobox C4	724	0.35
chr1_32205139_32205290	0.05	BAI2	brain-specific angiogenesis inhibitor 2	5119	0.16
chr19_6393244_6393475	0.05	GTF2F1	general transcription factor IIF, polypeptide 1, 74kDa	112	0.91
chr16_70456934_70457085	0.05	ST3GAL2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	15982	0.11
chr9_111773050_111773591	0.05	CTNNAL1	catenin (cadherin-associated protein), alpha-like 1	2459	0.23
chr2_160471179_160471674	0.05	AC009506.1		381	0.66
chr2_108994212_108994393	0.05	SULT1C4	sulfotransferase family, cytosolic, 1C, member 4	166	0.96
chrX_98854100_98854251	0.05	ENSG00000252430	.	213901	0.03
chr22_22020368_22020729	0.05	PPIL2	peptidylprolyl isomerase (cyclophilin)-like 2	190	0.88
chr5_54070623_54070885	0.05	ENSG00000221073	.	78022	0.1
chr1_22379888_22380679	0.05	CDC42	cell division cycle 42	493	0.71
chr19_5339568_5339818	0.05	PTPRS	protein tyrosine phosphatase, receptor type, S	1121	0.59
chr19_54475084_54475235	0.04	CACNG8	calcium channel, voltage-dependent, gamma subunit 8	8865	0.1
chr11_61584512_61584663	0.04	FADS1	fatty acid desaturase 1	47	0.89
chr11_119599926_119600166	0.04	CTD-2523D13.2		247	0.49
chr17_41737027_41737178	0.04	MEOX1	mesenchyme homeobox 1	1829	0.33
chr2_203735613_203735883	0.04	ICA1L	islet cell autoantigen 1,69kDa-like	21	0.98
chr11_64546452_64546665	0.04	SF1	splicing factor 1	300	0.83
chr3_71478030_71478538	0.04	ENSG00000221264	.	112956	0.06
chr17_47841796_47842381	0.04	FAM117A	family with sequence similarity 117, member A	559	0.72
chr8_146012278_146012963	0.04	ZNF34	zinc finger protein 34	69	0.94
chr12_18876500_18876651	0.04	PLCZ1	phospholipase C, zeta 1	4028	0.24

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of CREB5_CREM_JUNB

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0021819	layer formation in cerebral cortex(GO:0021819)
0.0	0.2	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.1	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.2	GO:0035519	protein K29-linked ubiquitination(GO:0035519)
0.0	0.1	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.2	GO:0043084	penile erection(GO:0043084)
0.0	0.1	GO:0021520	spinal cord motor neuron cell fate specification(GO:0021520)
0.0	0.1	GO:0030644	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.0	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.0	0.0	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0046520	sphingoid biosynthetic process(GO:0046520)
0.0	0.0	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.0	0.0	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.1	GO:0032933	SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0	0.0	GO:0003099	positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.0	0.0	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.1	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0031512	motile primary cilium(GO:0031512)
0.2	GO:0031527	filopodium membrane(GO:0031527)
0.2	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.1	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.1	GO:0002178	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1	GO:0005915	zonula adherens(GO:0005915)
0.1	GO:0005828	kinetochore microtubule(GO:0005828)
0.1	GO:0001740	Barr body(GO:0001740)
0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.2	GO:0034452	dynactin binding(GO:0034452)
0.1	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.3	GO:0005522	profilin binding(GO:0005522)
0.1	GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.2	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.1	GO:0016454	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1	GO:0000247	C-8 sterol isomerase activity(GO:0000247)
0.1	GO:0004111	creatine kinase activity(GO:0004111)
0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.1	GO:0030507	spectrin binding(GO:0030507)
0.1	GO:0019211	phosphatase activator activity(GO:0019211)
0.3	GO:0005184	neuropeptide hormone activity(GO:0005184)
0.0	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	GO:0004427	inorganic diphosphatase activity(GO:0004427)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.2	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.2	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity

Results for CREB5_CREM_JUNB

Z-value: 0.60

Motif logo

Transcription factors associated with CREB5_CREM_JUNB

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the CREB5_CREM_JUNB motif across conditions

Conditions sorted by the z-value of the CREB5_CREM_JUNB motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of CREB5_CREM_JUNB

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: