Project

ENCODE: H3K4me3 ChIP-Seq of primary human cells

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for CUX1

Z-value: 1.42

Motif logo

Transcription factors associated with CUX1

Gene Symbol	Gene ID	Gene Info
CUX1 Ensembl NCBI GeneCards UniProt	ENSG00000257923.5	CUX1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
CUX1	chr7_101460259_101460698	404	0.873916	-0.77	1.5e-02	Click!
CUX1	chr7_101459490_101459645	266	0.931579	-0.76	1.7e-02	Click!
CUX1	chr7_101459208_101459407	6	0.982319	-0.75	2.0e-02	Click!
CUX1	chr7_101397584_101398512	60911	0.121573	-0.61	8.3e-02	Click!
CUX1	chr7_101457714_101458422	891	0.644913	-0.58	9.8e-02	Click!

Activity of the CUX1 motif across conditions

Conditions sorted by the z-value of the CUX1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chrX_69674453_69675874	0.58	DLG3	discs, large homolog 3 (Drosophila)	217	0.75
chrX_39964334_39965624	0.34	BCOR	BCL6 corepressor	8323	0.32
chr1_161038546_161039545	0.33	ARHGAP30	Rho GTPase activating protein 30	411	0.65
chr9_93577957_93578337	0.32	SYK	spleen tyrosine kinase	11623	0.32
chr13_113597266_113598290	0.32	MCF2L	MCF.2 cell line derived transforming sequence-like	24979	0.15
chr22_29601932_29602692	0.30	EMID1	EMI domain containing 1	400	0.8
chr7_67384045_67384316	0.27	ENSG00000265600	.	562513	0.0
chr8_68304896_68305241	0.27	ARFGEF1	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	49156	0.18
chr5_1110808_1112337	0.26	SLC12A7	solute carrier family 12 (potassium/chloride transporter), member 7	578	0.75
chr1_245951382_245951568	0.26	RP11-522M21.3		111695	0.07
chr16_28506747_28507012	0.25	CLN3	ceroid-lipofuscinosis, neuronal 3	24	0.94
chr9_92275535_92275686	0.25	GADD45G	growth arrest and DNA-damage-inducible, gamma	55657	0.16
chr6_170604225_170605407	0.24	FAM120B	family with sequence similarity 120B	407	0.83
chr10_101088892_101089952	0.24	CNNM1	cyclin M1	266	0.95
chr1_22345507_22345745	0.23	ENSG00000201273	.	8148	0.1
chr11_14665333_14666638	0.23	PDE3B	phosphodiesterase 3B, cGMP-inhibited	608	0.56
chr2_238607001_238607152	0.23	LRRFIP1	leucine rich repeat (in FLII) interacting protein 1	6094	0.25
chr6_54711000_54712080	0.22	FAM83B	family with sequence similarity 83, member B	29	0.98
chr20_52492319_52492470	0.22	AC005220.3		64305	0.13
chr13_33589965_33590391	0.22	KL	klotho	29	0.98
chr3_150887706_150887956	0.21	ENSG00000199994	.	18055	0.16
chr17_57408824_57410302	0.20	YPEL2	yippee-like 2 (Drosophila)	500	0.78
chr17_21279729_21280949	0.20	KCNJ12	potassium inwardly-rectifying channel, subfamily J, member 12	830	0.69
chr13_113237033_113237219	0.20	TUBGCP3	tubulin, gamma complex associated protein 3	5313	0.28
chr16_89766857_89768141	0.20	SPATA2L	spermatogenesis associated 2-like	549	0.59
chr21_47344013_47344164	0.20	PRED62	Uncharacterized protein	8389	0.2
chr20_39122695_39122846	0.20	ENSG00000252434	.	77255	0.12
chr1_192130669_192130880	0.19	RGS18	regulator of G-protein signaling 18	3187	0.4
chr12_14731074_14731371	0.19	PLBD1	phospholipase B domain containing 1	9939	0.15
chr2_16615403_16615554	0.19	AC104623.2		88966	0.1
chr2_103042024_103042175	0.19	IL18RAP	interleukin 18 receptor accessory protein	5953	0.15
chr22_31613545_31613991	0.19	ENSG00000199695	.	5071	0.12
chr6_20404021_20405019	0.19	E2F3	E2F transcription factor 3	486	0.77
chr10_106085822_106086336	0.19	ITPRIP	inositol 1,4,5-trisphosphate receptor interacting protein	2603	0.2
chr20_3293982_3294133	0.19	C20orf194	chromosome 20 open reading frame 194	27551	0.12
chr4_38602953_38603104	0.19	RP11-617D20.1		23168	0.2
chr12_12735789_12735940	0.18	DUSP16	dual specificity phosphatase 16	20547	0.19
chrX_152599728_152600567	0.18	ZNF275	zinc finger protein 275	534	0.76
chr15_94841194_94841722	0.18	MCTP2	multiple C2 domains, transmembrane 2	28	0.99
chr2_74691535_74692741	0.18	MOGS	mannosyl-oligosaccharide glucosidase	351	0.67
chr22_30577376_30577527	0.18	RP3-438O4.4		25647	0.13
chr9_21964953_21966022	0.18	C9orf53	chromosome 9 open reading frame 53	1650	0.31
chr22_41843038_41844299	0.18	TOB2	transducer of ERBB2, 2	641	0.64
chr4_97275136_97275287	0.18	ENSG00000201640	.	5022	0.36
chr22_17577263_17577414	0.18	IL17RA	interleukin 17 receptor A	11489	0.15
chr16_127905_128996	0.18	MPG	N-methylpurine-DNA glycosylase	194	0.87
chr3_112686974_112687125	0.18	CD200R1	CD200 receptor 1	6710	0.17
chr17_55889172_55889323	0.18	ENSG00000222976	.	22437	0.16
chr8_97352110_97352386	0.18	ENSG00000199732	.	30698	0.17
chr1_108492584_108492735	0.17	VAV3-AS1	VAV3 antisense RNA 1	14406	0.21
chrX_67913478_67914353	0.17	STARD8	StAR-related lipid transfer (START) domain containing 8	422	0.91
chr1_204962096_204962247	0.17	NFASC	neurofascin	4141	0.24
chr7_64461546_64461954	0.17	ERV3-1	endogenous retrovirus group 3, member 1	5281	0.17
chr17_72740646_72740797	0.17	ENSG00000264624	.	4031	0.11
chr19_54714075_54714317	0.17	RPS9	ribosomal protein S9	9168	0.07
chr12_107153685_107153836	0.17	RIC8B	RIC8 guanine nucleotide exchange factor B	14613	0.17
chr1_181068882_181069172	0.17	IER5	immediate early response 5	11389	0.23
chr13_27335081_27335232	0.17	GPR12	G protein-coupled receptor 12	234	0.96
chr2_149894818_149895436	0.17	LYPD6B	LY6/PLAUR domain containing 6B	105	0.98
chr3_50395480_50396917	0.17	TMEM115	transmembrane protein 115	843	0.33
chr19_13906290_13907522	0.17	ZSWIM4	zinc finger, SWIM-type containing 4	632	0.39
chr17_41790734_41791669	0.17	ENSG00000215964	.	34367	0.11
chr3_71829345_71829567	0.17	PROK2	prokineticin 2	4756	0.22
chr19_32836514_32837661	0.17	ZNF507	zinc finger protein 507	462	0.81
chr3_46504181_46504332	0.17	LTF	lactotransferrin	905	0.54
chr2_9142725_9143476	0.16	MBOAT2	membrane bound O-acyltransferase domain containing 2	694	0.76
chr16_72910024_72910217	0.16	ENSG00000251868	.	54229	0.12
chr2_63276750_63277690	0.16	OTX1	orthodenticle homeobox 1	28	0.97
chr12_42862786_42862937	0.16	RP11-328C8.4		9693	0.15
chr6_42504782_42504933	0.16	UBR2	ubiquitin protein ligase E3 component n-recognin 2	26943	0.17
chr22_45604259_45604410	0.16	KIAA0930	KIAA0930	2604	0.24
chr7_105898290_105898441	0.16	NAMPT	nicotinamide phosphoribosyltransferase	27002	0.18
chr11_65627927_65628967	0.16	MUS81	MUS81 structure-specific endonuclease subunit	89	0.82
chr6_159476816_159477190	0.16	TAGAP	T-cell activation RhoGTPase activating protein	10819	0.2
chr9_94184266_94184417	0.16	NFIL3	nuclear factor, interleukin 3 regulated	1803	0.49
chr5_180631418_180632621	0.16	TRIM7	tripartite motif containing 7	153	0.85
chr15_92400679_92401101	0.16	SLCO3A1	solute carrier organic anion transporter family, member 3A1	3539	0.31
chr8_71128828_71128979	0.16	NCOA2	nuclear receptor coactivator 2	28707	0.22
chr21_47789248_47789399	0.16	PCNT	pericentrin	45287	0.1
chr2_220251514_220252585	0.16	DNPEP	aspartyl aminopeptidase	19	0.94
chr19_54783961_54784112	0.16	LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	317	0.74
chr19_38494188_38494741	0.16	CTC-244M17.1		39971	0.13
chr2_31541639_31542033	0.16	EHD3	EH-domain containing 3	84633	0.08
chr6_1624554_1625514	0.16	FOXC1	forkhead box C1	14353	0.29
chrX_68384708_68385863	0.16	PJA1	praja ring finger 1, E3 ubiquitin protein ligase	5	0.99
chrX_12929174_12929325	0.16	TLR8-AS1	TLR8 antisense RNA 1	2797	0.26
chr3_101797946_101798097	0.16	ZPLD1	zona pellucida-like domain containing 1	20067	0.26
chr15_50356488_50356639	0.16	ATP8B4	ATPase, class I, type 8B, member 4	16979	0.23
chr12_92755876_92756027	0.16	RP11-693J15.4		59356	0.12
chr10_14920855_14921866	0.16	SUV39H2	suppressor of variegation 3-9 homolog 2 (Drosophila)	439	0.82
chr1_167572076_167572227	0.16	RCSD1	RCSD domain containing 1	27179	0.16
chr2_113885287_113885446	0.16	IL1RN	interleukin 1 receptor antagonist	228	0.91
chr11_67807279_67808325	0.16	TCIRG1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3	1229	0.3
chr3_4793449_4793634	0.16	ENSG00000239126	.	126845	0.05
chr3_32344642_32344793	0.16	ENSG00000207857	.	43497	0.14
chr2_43188289_43188440	0.16	ENSG00000207087	.	130268	0.05
chr18_74843262_74844680	0.16	MBP	myelin basic protein	331	0.94
chr10_70883973_70885223	0.15	VPS26A	vacuolar protein sorting 26 homolog A (S. pombe)	595	0.74
chr2_197076357_197076527	0.15	ENSG00000239161	.	3604	0.24
chr15_83540435_83540586	0.15	HOMER2	homer homolog 2 (Drosophila)	7499	0.17
chr19_2494417_2495562	0.15	ENSG00000252962	.	8150	0.15
chr2_217180593_217180957	0.15	AC069155.1		12727	0.18
chr3_15578534_15578685	0.15	COLQ	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	15351	0.14
chr9_117568588_117568807	0.15	TNFSF15	tumor necrosis factor (ligand) superfamily, member 15	291	0.92
chr9_124016304_124016710	0.15	GSN	gelsolin	13831	0.14
chr9_33523659_33524999	0.15	ANKRD18B	ankyrin repeat domain 18B	63	0.97
chr19_45754620_45755932	0.15	MARK4	MAP/microtubule affinity-regulating kinase 4	726	0.57
chr14_21249278_21249626	0.15	RNASE6	ribonuclease, RNase A family, k6	242	0.86
chrX_13751428_13751579	0.15	TRAPPC2	trafficking protein particle complex 2	1172	0.37
chr5_10607962_10608181	0.15	ANKRD33B-AS1	ANKRD33B antisense RNA 1	20266	0.2
chr16_1991808_1991959	0.15	MSRB1	methionine sulfoxide reductase B1	1241	0.18
chrX_13955774_13956778	0.15	GPM6B	glycoprotein M6B	258	0.95
chr2_28811248_28811399	0.15	PLB1	phospholipase B1	13463	0.23
chr6_156338794_156338945	0.15	ENSG00000221456	.	70938	0.14
chr12_48212353_48213256	0.15	HDAC7	histone deacetylase 7	241	0.91
chr12_92424206_92424357	0.15	C12orf79	chromosome 12 open reading frame 79	106516	0.07
chr2_190444828_190446170	0.15	SLC40A1	solute carrier family 40 (iron-regulated transporter), member 1	114	0.98
chr5_142193879_142194030	0.15	ARHGAP26	Rho GTPase activating protein 26	41672	0.17
chr18_53006641_53006980	0.15	TCF4	transcription factor 4	12418	0.28
chr8_142105945_142106235	0.15	DENND3	DENN/MADD domain containing 3	21287	0.19
chr2_238395971_238396408	0.15	MLPH	melanophilin	270	0.92
chr22_31631160_31631361	0.15	ENSG00000202019	.	5102	0.12
chr2_108443697_108444171	0.15	RGPD4	RANBP2-like and GRIP domain containing 4	541	0.87
chr2_155001115_155001266	0.15	ENSG00000266512	.	1530	0.54
chr22_17598033_17598230	0.15	CECR6	cat eye syndrome chromosome region, candidate 6	4012	0.17
chr2_60774113_60774264	0.15	BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	6352	0.26
chr1_16769456_16769607	0.15	NECAP2	NECAP endocytosis associated 2	2300	0.23
chr11_126188773_126189028	0.15	RP11-712L6.5	Uncharacterized protein	14687	0.1
chr1_45274565_45275349	0.15	BTBD19	BTB (POZ) domain containing 19	762	0.37
chr20_48301152_48301303	0.15	B4GALT5	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5	29188	0.16
chr1_234658507_234658658	0.15	TARBP1	TAR (HIV-1) RNA binding protein 1	43733	0.14
chr12_11926562_11926926	0.15	ETV6	ets variant 6	21309	0.26
chr12_121340609_121341729	0.15	SPPL3	signal peptide peptidase like 3	4	0.98
chr4_26263054_26263205	0.15	RBPJ	recombination signal binding protein for immunoglobulin kappa J region	11100	0.31
chr7_150131124_150131275	0.15	GIMAP8	GTPase, IMAP family member 8	16519	0.14
chr7_105318075_105318226	0.15	ATXN7L1	ataxin 7-like 1	1459	0.53
chr15_50359492_50359643	0.15	ATP8B4	ATPase, class I, type 8B, member 4	19983	0.22
chr9_5493967_5494181	0.15	PDCD1LG2	programmed cell death 1 ligand 2	16471	0.2
chr2_208091726_208091877	0.15	AC007879.5		27175	0.18
chr2_30454378_30455881	0.14	LBH	limb bud and heart development	83	0.98
chr3_51691608_51691759	0.14	TEX264	testis expressed 264	5026	0.17
chr13_88325876_88326239	0.14	SLITRK5	SLIT and NTRK-like family, member 5	559	0.85
chr16_29471210_29471476	0.14	SULT1A4	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4	133	0.91
chr12_117536177_117536841	0.14	TESC	tescalcin	742	0.76
chr19_14551433_14551660	0.14	PKN1	protein kinase N1	474	0.7
chr16_53124890_53125176	0.14	CHD9	chromodomain helicase DNA binding protein 9	8039	0.24
chr8_68296421_68296572	0.14	ARFGEF1	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	40584	0.21
chr3_131753321_131753947	0.14	CPNE4	copine IV	210	0.96
chr17_40811022_40812282	0.14	TUBG2	tubulin, gamma 2	329	0.76
chr19_38736860_38737011	0.14	SPINT2	serine peptidase inhibitor, Kunitz type, 2	2260	0.16
chr8_77320453_77320604	0.14	ENSG00000222231	.	142561	0.05
chr4_11652870_11653079	0.14	HS3ST1	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	221585	0.02
chr11_118023255_118024161	0.14	SCN4B	sodium channel, voltage-gated, type IV, beta subunit	105	0.96
chr12_132475297_132475448	0.14	ENSG00000271905	.	10948	0.16
chr21_45527300_45528294	0.14	PWP2	PWP2 periodic tryptophan protein homolog (yeast)	543	0.75
chr20_3189609_3190930	0.14	ITPA	inosine triphosphatase (nucleoside triphosphate pyrophosphatase)	98	0.95
chr1_158218516_158218667	0.14	CD1A	CD1a molecule	5336	0.22
chr2_219124080_219124231	0.14	GPBAR1	G protein-coupled bile acid receptor 1	64	0.94
chr5_63461313_63462499	0.14	RNF180	ring finger protein 180	83	0.99
chr15_48604529_48604680	0.14	ENSG00000202542	.	13264	0.17
chr2_198167617_198167768	0.14	ANKRD44-IT1	ANKRD44 intronic transcript 1 (non-protein coding)	449	0.8
chr17_76879212_76879961	0.14	TIMP2	TIMP metallopeptidase inhibitor 2	9354	0.14
chr22_30053890_30054041	0.14	NF2	neurofibromin 2 (merlin)	53977	0.08
chr1_207244470_207244690	0.14	PFKFB2	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	6231	0.14
chr7_148844568_148845756	0.14	ZNF398	zinc finger protein 398	57	0.97
chr17_2699734_2700214	0.14	RAP1GAP2	RAP1 GTPase activating protein 2	198	0.94
chr1_170633420_170634117	0.14	PRRX1	paired related homeobox 1	690	0.8
chr10_22894404_22894761	0.14	PIP4K2A	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	13940	0.29
chr4_38802207_38802358	0.14	TLR1	toll-like receptor 1	3715	0.19
chr11_75490080_75490231	0.14	CTD-2530H12.2		3206	0.13
chr6_88875424_88876640	0.14	CNR1	cannabinoid receptor 1 (brain)	46	0.99
chr14_89290449_89291591	0.14	TTC8	tetratricopeptide repeat domain 8	9	0.97
chr10_99090099_99090250	0.14	RP11-452K12.4		4147	0.13
chr7_31851375_31851526	0.14	ENSG00000223070	.	17588	0.29
chr5_15704054_15704205	0.14	FBXL7	F-box and leucine-rich repeat protein 7	88038	0.09
chr6_53109316_53109571	0.14	ENSG00000206908	.	25384	0.15
chr4_113626760_113627887	0.14	ENSG00000202536	.	49750	0.09
chr1_28571461_28571612	0.14	RP5-1092A3.4		3572	0.14
chr18_53007051_53007202	0.14	TCF4	transcription factor 4	12102	0.28
chr17_61106096_61106247	0.14	TANC2	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	19250	0.23
chr19_36207272_36208543	0.14	KMT2B	Histone-lysine N-methyltransferase 2B	1014	0.26
chr9_88137440_88138079	0.14	AGTPBP1	ATP/GTP binding protein 1	158442	0.04
chr17_77019963_77021139	0.14	C1QTNF1	C1q and tumor necrosis factor related protein 1	208	0.91
chr16_67282110_67283381	0.13	SLC9A5	solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5	108	0.89
chr7_148237370_148237521	0.13	C7orf33	chromosome 7 open reading frame 33	50212	0.15
chr11_67041225_67041376	0.13	ADRBK1	adrenergic, beta, receptor kinase 1	7348	0.12
chr3_47031255_47031478	0.13	NBEAL2	neurobeachin-like 2	5445	0.19
chr20_4807814_4807965	0.13	RASSF2	Ras association (RalGDS/AF-6) domain family member 2	3598	0.24
chr14_102320200_102320351	0.13	CTD-2017C7.1		14407	0.16
chr20_47414178_47414329	0.13	PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	30167	0.21
chr15_100017896_100018047	0.13	MEF2A	myocyte enhancer factor 2A	601	0.77
chr19_47610168_47610319	0.13	SAE1	SUMO1 activating enzyme subunit 1	6288	0.16
chr10_81026521_81026806	0.13	ZMIZ1	zinc finger, MIZ-type containing 1	39312	0.18
chr1_23860213_23860364	0.13	E2F2	E2F transcription factor 2	2576	0.26
chr11_119953003_119953290	0.13	TRIM29	tripartite motif containing 29	38462	0.18
chr14_24803093_24804202	0.13	ADCY4	adenylate cyclase 4	306	0.72
chr8_27262752_27262933	0.13	PTK2B	protein tyrosine kinase 2 beta	7873	0.23
chr19_14223228_14223791	0.13	PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	1491	0.22
chr6_20267392_20267543	0.13	MBOAT1	membrane bound O-acyltransferase domain containing 1	54797	0.13
chr2_11483078_11484442	0.13	ROCK2	Rho-associated, coiled-coil containing protein kinase 2	951	0.65

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of CUX1

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0016242	negative regulation of macroautophagy(GO:0016242)
0.1	0.2	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.1	0.2	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.1	0.2	GO:0019471	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0	0.1	GO:0010966	regulation of phosphate transport(GO:0010966)
0.0	0.1	GO:0015801	aromatic amino acid transport(GO:0015801)
0.0	0.1	GO:0002866	positive regulation of acute inflammatory response to antigenic stimulus(GO:0002866)
0.0	0.1	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0	0.1	GO:0003181	atrioventricular valve development(GO:0003171) atrioventricular valve morphogenesis(GO:0003181)
0.0	0.1	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0	0.1	GO:0070340	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.1	GO:0071224	cellular response to peptidoglycan(GO:0071224)
0.0	0.1	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.0	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.1	GO:0002538	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.1	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.2	GO:0051024	positive regulation of immunoglobulin secretion(GO:0051024)
0.0	0.3	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.2	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0	0.2	GO:1903672	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.0	0.1	GO:0035581	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0034625	fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0	0.1	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.1	GO:0045672	positive regulation of osteoclast differentiation(GO:0045672)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.1	GO:0016102	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0	0.1	GO:0060049	regulation of protein glycosylation(GO:0060049)
0.0	0.1	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.1	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642)
0.0	0.2	GO:0031115	negative regulation of microtubule polymerization(GO:0031115)
0.0	0.1	GO:0046607	positive regulation of centrosome cycle(GO:0046607)
0.0	0.1	GO:0032957	inositol trisphosphate metabolic process(GO:0032957)
0.0	0.1	GO:0045075	interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0	0.1	GO:2001280	regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0	0.1	GO:0001820	serotonin secretion(GO:0001820)
0.0	0.1	GO:0045835	negative regulation of meiotic nuclear division(GO:0045835)
0.0	0.1	GO:0042819	pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.1	GO:0003057	regulation of the force of heart contraction by chemical signal(GO:0003057)
0.0	0.1	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.0	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.0	0.1	GO:0032495	response to muramyl dipeptide(GO:0032495)
0.0	0.1	GO:0009111	vitamin catabolic process(GO:0009111) fat-soluble vitamin catabolic process(GO:0042363)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.1	GO:0060535	trachea cartilage morphogenesis(GO:0060535) cartilage morphogenesis(GO:0060536)
0.0	0.1	GO:0048342	paraxial mesodermal cell differentiation(GO:0048342) paraxial mesodermal cell fate commitment(GO:0048343)
0.0	0.0	GO:0032060	bleb assembly(GO:0032060)
0.0	0.1	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.2	GO:0050957	equilibrioception(GO:0050957)
0.0	0.1	GO:0030853	negative regulation of granulocyte differentiation(GO:0030853)
0.0	0.1	GO:0033262	regulation of nuclear cell cycle DNA replication(GO:0033262)
0.0	0.1	GO:0010587	miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0	0.1	GO:0014041	regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0	0.1	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.1	GO:0060013	righting reflex(GO:0060013)
0.0	0.1	GO:0042711	maternal behavior(GO:0042711) parental behavior(GO:0060746)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.0	GO:0032227	negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0	0.2	GO:0006884	cell volume homeostasis(GO:0006884)
0.0	0.1	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.1	GO:0006307	DNA dealkylation involved in DNA repair(GO:0006307)
0.0	0.1	GO:0018101	protein citrullination(GO:0018101)
0.0	0.1	GO:0030502	negative regulation of bone mineralization(GO:0030502)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.1	GO:0015722	canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
0.0	0.0	GO:0060510	lung saccule development(GO:0060430) Type II pneumocyte differentiation(GO:0060510)
0.0	0.1	GO:0006344	maintenance of chromatin silencing(GO:0006344)
0.0	0.1	GO:0007000	nucleolus organization(GO:0007000)
0.0	0.1	GO:0055064	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.1	GO:0048003	antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003)
0.0	0.1	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.1	GO:0015816	glycine transport(GO:0015816)
0.0	0.2	GO:0090398	cellular senescence(GO:0090398)
0.0	0.0	GO:0032328	alanine transport(GO:0032328)
0.0	0.1	GO:0022605	oogenesis stage(GO:0022605)
0.0	0.1	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.0	0.1	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.0	0.1	GO:0009235	cobalamin metabolic process(GO:0009235)
0.0	0.1	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.0	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.1	GO:1903224	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.1	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.2	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
0.0	0.1	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.1	GO:0046185	aldehyde catabolic process(GO:0046185)
0.0	0.1	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.1	GO:0006177	GMP biosynthetic process(GO:0006177)
0.0	0.0	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.0	0.0	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.0	GO:0042268	regulation of cytolysis(GO:0042268)
0.0	0.0	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.1	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0014049	positive regulation of glutamate secretion(GO:0014049)
0.0	0.0	GO:0071801	regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0	0.1	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0	0.0	GO:0002407	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0	0.1	GO:0030146	obsolete diuresis(GO:0030146)
0.0	0.0	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.2	GO:0015669	gas transport(GO:0015669)
0.0	0.0	GO:0097709	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0	0.1	GO:0036230	granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.0	0.1	GO:0048261	negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0	0.0	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.1	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.0	0.1	GO:0002634	regulation of germinal center formation(GO:0002634)
0.0	0.0	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.0	GO:0000019	regulation of mitotic recombination(GO:0000019)
0.0	0.0	GO:0021978	telencephalon regionalization(GO:0021978)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.1	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.0	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0	0.0	GO:0070266	necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300)
0.0	0.0	GO:0042364	water-soluble vitamin biosynthetic process(GO:0042364)
0.0	0.0	GO:0033622	integrin activation(GO:0033622)
0.0	0.0	GO:0061318	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.2	GO:0021846	cell proliferation in forebrain(GO:0021846)
0.0	0.0	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.1	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.0	GO:0034135	regulation of toll-like receptor 2 signaling pathway(GO:0034135)
0.0	0.0	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.0	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.1	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.0	GO:0001787	natural killer cell proliferation(GO:0001787) regulation of natural killer cell proliferation(GO:0032817)
0.0	0.0	GO:0051299	centrosome separation(GO:0051299)
0.0	0.0	GO:0007406	negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0	0.0	GO:0060004	reflex(GO:0060004)
0.0	0.1	GO:0046504	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.0	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.1	GO:2000193	positive regulation of fatty acid transport(GO:2000193)
0.0	0.0	GO:0001865	NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0	0.0	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.0	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.0	0.0	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.0	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.0	0.1	GO:0032876	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.0	GO:1901978	positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.0	0.3	GO:0051318	G1 phase(GO:0051318)
0.0	0.2	GO:0006611	protein export from nucleus(GO:0006611)
0.0	0.1	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.0	GO:0032494	response to peptidoglycan(GO:0032494)
0.0	0.0	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.0	GO:1901881	positive regulation of protein depolymerization(GO:1901881)
0.0	0.0	GO:0046100	hypoxanthine metabolic process(GO:0046100)
0.0	0.0	GO:0061088	regulation of sequestering of zinc ion(GO:0061088)
0.0	0.0	GO:2000794	positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.0	0.1	GO:0034035	purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0	0.0	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.0	GO:0060484	lung-associated mesenchyme development(GO:0060484)
0.0	0.0	GO:0044240	multicellular organism lipid catabolic process(GO:0044240)
0.0	0.0	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.1	GO:0009650	UV protection(GO:0009650)
0.0	0.0	GO:0031558	obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0	0.0	GO:0009405	pathogenesis(GO:0009405)
0.0	0.0	GO:0016241	regulation of macroautophagy(GO:0016241)
0.0	0.1	GO:0045408	regulation of interleukin-6 biosynthetic process(GO:0045408)
0.0	0.0	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.0	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	0.0	GO:0051447	negative regulation of meiotic cell cycle(GO:0051447)
0.0	0.0	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.0	0.2	GO:0007140	male meiosis(GO:0007140)
0.0	0.0	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.0	0.0	GO:0002606	positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0	0.0	GO:0003351	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.0	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0	0.0	GO:0003310	pancreatic A cell differentiation(GO:0003310)
0.0	0.0	GO:0071681	response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.0	0.1	GO:0007252	I-kappaB phosphorylation(GO:0007252)
0.0	0.1	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.0	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0030904	retromer complex(GO:0030904)
0.0	0.2	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.1	GO:0042629	mast cell granule(GO:0042629)
0.0	0.1	GO:0001939	female pronucleus(GO:0001939)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.2	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.1	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.1	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.1	GO:0033162	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0	0.2	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.0	0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.0	GO:0044462	external encapsulating structure part(GO:0044462)
0.0	0.1	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.0	0.1	GO:1903561	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.1	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.0	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.2	GO:0031528	microvillus membrane(GO:0031528)
0.0	0.1	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	0.0	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.1	GO:0031312	extrinsic component of organelle membrane(GO:0031312)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.1	GO:0070822	Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822)
0.0	0.0	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.1	GO:0031262	Ndc80 complex(GO:0031262)
0.0	0.1	GO:0030870	Mre11 complex(GO:0030870)
0.0	0.3	GO:0005776	autophagosome(GO:0005776)
0.0	0.1	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.0	GO:0045277	mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.1	0.2	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0	0.1	GO:0015142	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0	0.1	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.2	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.2	GO:0031545	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.1	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.1	GO:0019958	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.1	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.3	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.1	GO:0045118	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.1	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.2	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:1901567	icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0	0.1	GO:0042910	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.2	GO:0047429	nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0	0.1	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.1	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.1	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0071553	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0004992	platelet activating factor receptor activity(GO:0004992)
0.0	0.1	GO:0005000	vasopressin receptor activity(GO:0005000)
0.0	0.1	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0	0.1	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.1	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.0	GO:0015199	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0	0.2	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.1	GO:0000247	C-8 sterol isomerase activity(GO:0000247)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.0	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.1	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	0.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.1	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.1	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.1	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)
0.0	0.1	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.1	GO:0005275	amine transmembrane transporter activity(GO:0005275)
0.0	0.1	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.1	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.2	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.1	GO:0016889	endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.1	GO:0048156	tau protein binding(GO:0048156)
0.0	0.1	GO:0031628	opioid receptor binding(GO:0031628)
0.0	0.2	GO:0031078	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0070215	obsolete MDM2 binding(GO:0070215)
0.0	0.1	GO:0008273	calcium, potassium:sodium antiporter activity(GO:0008273)
0.0	0.1	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.0	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.1	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.1	GO:0042805	actinin binding(GO:0042805)
0.0	0.2	GO:0008199	ferric iron binding(GO:0008199)
0.0	0.0	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.3	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.1	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	0.1	GO:0070008	serine-type exopeptidase activity(GO:0070008)
0.0	0.1	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.0	GO:0004712	protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0	0.1	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.0	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.0	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.0	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.1	GO:0016934	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0	0.2	GO:0070001	aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0	0.1	GO:0003840	gamma-glutamyltransferase activity(GO:0003840)
0.0	0.1	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0	0.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.1	GO:0008198	ferrous iron binding(GO:0008198)
0.0	0.0	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)
0.0	0.1	GO:0015385	sodium:proton antiporter activity(GO:0015385)
0.0	0.1	GO:0000832	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0	0.2	GO:0005248	voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0	0.1	GO:0004383	guanylate cyclase activity(GO:0004383)
0.0	0.2	GO:0000155	phosphorelay sensor kinase activity(GO:0000155)
0.0	0.0	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.0	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.0	GO:0035198	miRNA binding(GO:0035198)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.0	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.0	0.0	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0	0.0	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0035381	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0	0.1	GO:0017081	chloride channel regulator activity(GO:0017081)
0.0	0.1	GO:0001619	obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0	0.1	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.1	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.1	GO:0005123	death receptor binding(GO:0005123)
0.0	0.0	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.0	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.0	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.1	GO:0016918	retinal binding(GO:0016918)
0.0	0.0	GO:0008174	mRNA methyltransferase activity(GO:0008174)
0.0	0.0	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.0	GO:0008061	chitin binding(GO:0008061)
0.0	0.0	GO:0004515	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0	0.0	GO:0004551	nucleotide diphosphatase activity(GO:0004551)
0.0	0.1	GO:0033558	protein deacetylase activity(GO:0033558)
0.0	0.0	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.0	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.0	GO:0035252	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	SIG CHEMOTAXIS	Genes related to chemotaxis
0.1	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	PID S1P S1P3 PATHWAY	S1P3 pathway
0.1	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.2	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.3	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.4	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.1	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.3	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.1	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.5	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.4	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.1	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	Genes involved in Gastrin-CREB signalling pathway via PKC and MAPK
0.3	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.0	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.1	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.2	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.2	REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	Genes involved in NRIF signals cell death from the nucleus
0.2	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.0	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI
0.2	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.2	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.2	REACTOME IRON UPTAKE AND TRANSPORT	Genes involved in Iron uptake and transport
0.2	REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.1	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.2	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.2	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	Genes involved in Activation of Kainate Receptors upon glutamate binding
0.2	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.1	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.2	REACTOME ACYL CHAIN REMODELLING OF PE	Genes involved in Acyl chain remodelling of PE
0.1	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events
0.2	REACTOME FGFR LIGAND BINDING AND ACTIVATION	Genes involved in FGFR ligand binding and activation
0.0	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network