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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for DBP

Z-value: 1.43

Motif logo

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Transcription factors associated with DBP

Gene Symbol Gene ID Gene Info
DBP
ENSG00000105516.6 D-box binding PAR bZIP transcription factor

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr19_49138973_49139430DBP13080.220749-0.881.8e-03Click!
chr19_49139505_49139656DBP10400.284260-0.844.8e-03Click!
chr19_49139809_49140053DBP6890.437960-0.752.0e-02Click!
chr19_49140164_49140638DBP2190.831467-0.703.4e-02Click!
chr19_49133396_49133547DBP43120.0889050.703.6e-02Click!

Activity of the DBP motif across conditions

Conditions sorted by the z-value of the DBP motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr21_28214648_28215240 0.59 ADAMTS1
 ADAM metallopeptidase with thrombospondin type 1 motif, 1
 393
 0.9
chrX_30327007_30327420 0.49 NR0B1
 nuclear receptor subfamily 0, group B, member 1
 282
 0.91
chr3_137486919_137487668 0.47 SOX14
 SRY (sex determining region Y)-box 14
 3714
 0.37
chr3_149094469_149095370 0.46 TM4SF1-AS1
 TM4SF1 antisense RNA 1
 646
 0.47
chr7_28725956_28726399 0.45 CREB5
 cAMP responsive element binding protein 5
 579
 0.86
chr1_157980267_157980690 0.44 KIRREL-IT1
 KIRREL intronic transcript 1 (non-protein coding)
 14862
 0.2
chr20_14317720_14318261 0.40 FLRT3
 fibronectin leucine rich transmembrane protein 3
 264
 0.94
chr13_67708586_67709053 0.40 PCDH9
 protocadherin 9
 93753
 0.09
chr6_27560724_27561227 0.40 ENSG00000206671
 .
 3216
 0.27
chr9_14400502_14400713 0.38 NFIB
 nuclear factor I/B
 1625
 0.51
chr5_54456050_54456451 0.36 GPX8
 glutathione peroxidase 8 (putative)
 252
 0.86
chr5_83017716_83018280 0.35 HAPLN1
 hyaluronan and proteoglycan link protein 1
 566
 0.78
chr1_99128119_99128537 0.34 SNX7
 sorting nexin 7
 549
 0.88
chr20_11871763_11872529 0.34 BTBD3
 BTB (POZ) domain containing 3
 171
 0.97
chr5_73110322_73110752 0.34 ARHGEF28
 Rho guanine nucleotide exchange factor (GEF) 28
 1194
 0.51
chr6_19838575_19839711 0.34 RP1-167F1.2
168
 0.95
chr13_93879365_93880233 0.33 GPC6
 glypican 6
 704
 0.82
chr7_22538999_22539909 0.33 STEAP1B
 STEAP family member 1B
 342
 0.91
chr6_1821527_1821700 0.32 FOXC1
 forkhead box C1
 210932
 0.02
chr15_39873424_39874712 0.32 THBS1
 thrombospondin 1
 774
 0.66
chr2_164592268_164592669 0.32 FIGN
 fidgetin
 49
 0.99
chr7_94025115_94025296 0.32 COL1A2
 collagen, type I, alpha 2
 1332
 0.57
chr2_106260790_106261225 0.32 NCK2
 NCK adaptor protein 2
 100347
 0.08
chr8_23711881_23712175 0.32 STC1
 stanniocalcin 1
 204
 0.95
chr4_111552866_111553567 0.31 PITX2
 paired-like homeodomain 2
 4960
 0.32
chr12_21652771_21652922 0.31 RECQL
 RecQ protein-like (DNA helicase Q1-like)
 1639
 0.29
chr1_157979860_157980080 0.31 KIRREL-IT1
 KIRREL intronic transcript 1 (non-protein coding)
 15370
 0.2
chr3_64253305_64253544 0.31 PRICKLE2
 prickle homolog 2 (Drosophila)
 231
 0.95
chr12_53443889_53444561 0.31 TENC1
 tensin like C1 domain containing phosphatase (tensin 2)
 255
 0.86
chr2_238322401_238322657 0.31 COL6A3
 collagen, type VI, alpha 3
 262
 0.93
chr15_96869491_96869741 0.30 NR2F2
 nuclear receptor subfamily 2, group F, member 2
 449
 0.57
chr5_38846105_38846894 0.30 OSMR
 oncostatin M receptor
 398
 0.91
chr9_18476160_18476529 0.30 ADAMTSL1
 ADAMTS-like 1
 2113
 0.45
chr18_72509166_72509431 0.29 ZNF407
 zinc finger protein 407
 166322
 0.04
chr6_128828944_128829440 0.29 RP1-86D1.4
2922
 0.22
chr7_54972295_54972520 0.29 ENSG00000252054
 .
 38896
 0.2
chr13_38442983_38443134 0.29 TRPC4
 transient receptor potential cation channel, subfamily C, member 4
 802
 0.72
chr16_86603613_86603777 0.29 RP11-463O9.5
2328
 0.23
chr1_157964729_157965124 0.29 KIRREL
 kin of IRRE like (Drosophila)
 1491
 0.45
chr2_216296824_216297216 0.29 FN1
 fibronectin 1
 3770
 0.26
chr17_29887718_29887925 0.28 ENSG00000207614
 .
 806
 0.46
chr22_28181066_28181439 0.28 MN1
 meningioma (disrupted in balanced translocation) 1
 16234
 0.25
chr2_46165643_46166035 0.28 PRKCE
 protein kinase C, epsilon
 62202
 0.14
chr3_50395480_50396917 0.28 TMEM115
 transmembrane protein 115
 843
 0.33
chr6_7697968_7698508 0.28 BMP6
 bone morphogenetic protein 6
 28792
 0.23
chr12_120241388_120241613 0.28 CIT
 citron (rho-interacting, serine/threonine kinase 21)
 313
 0.92
chr11_8830922_8831183 0.27 ST5
 suppression of tumorigenicity 5
 1144
 0.43
chr2_119532290_119532494 0.27 EN1
 engrailed homeobox 1
 72862
 0.12
chr13_33543979_33544184 0.27 KL
 klotho
 46126
 0.17
chr9_118918844_118919316 0.27 PAPPA
 pregnancy-associated plasma protein A, pappalysin 1
 2997
 0.34
chr4_124339787_124340099 0.27 SPRY1
 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
 18820
 0.3
chr19_4575630_4575781 0.27 SEMA6B
 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
 15885
 0.1
chr1_201915320_201915636 0.27 LMOD1
 leiomodin 1 (smooth muscle)
 237
 0.87
chr6_90927639_90927889 0.27 BACH2
 BTB and CNC homology 1, basic leucine zipper transcription factor 2
 78697
 0.1
chr7_139899946_139900413 0.27 ENSG00000199971
 .
 9292
 0.16
chr15_100651358_100651509 0.27 ADAMTS17
 ADAM metallopeptidase with thrombospondin type 1 motif, 17
 2121
 0.32
chr18_71356617_71356768 0.27 ENSG00000241866
 .
 55478
 0.18
chr2_119603311_119603908 0.27 EN1
 engrailed homeobox 1
 1645
 0.51
chr4_188523294_188523560 0.27 ZFP42
 ZFP42 zinc finger protein
 393498
 0.01
chr9_79520083_79520617 0.26 PRUNE2
 prune homolog 2 (Drosophila)
 651
 0.82
chr5_72746721_72747193 0.26 FOXD1
 forkhead box D1
 2605
 0.29
chr1_214397865_214398571 0.26 SMYD2
 SET and MYND domain containing 2
 56358
 0.16
chr4_169553568_169553728 0.26 PALLD
 palladin, cytoskeletal associated protein
 880
 0.63
chr17_13505362_13505866 0.26 HS3ST3A1
 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
 370
 0.91
chr18_57326676_57327097 0.26 CCBE1
 collagen and calcium binding EGF domains 1
 6508
 0.21
chr15_59663421_59663716 0.26 FAM81A
 family with sequence similarity 81, member A
 1324
 0.28
chr3_114342653_114342865 0.26 ZBTB20
 zinc finger and BTB domain containing 20
 294
 0.95
chr4_170190156_170190307 0.26 SH3RF1
 SH3 domain containing ring finger 1
 877
 0.72
chr9_91793130_91793737 0.26 SHC3
 SHC (Src homology 2 domain containing) transforming protein 3
 249
 0.95
chr10_104536223_104536534 0.26 WBP1L
 WW domain binding protein 1-like
 372
 0.83
chr20_57089963_57090433 0.26 APCDD1L
 adenomatosis polyposis coli down-regulated 1-like
 11
 0.98
chr3_112354765_112355126 0.26 CCDC80
 coiled-coil domain containing 80
 1999
 0.4
chr8_93113958_93114847 0.26 RUNX1T1
 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
 1052
 0.69
chr1_98514742_98514981 0.26 ENSG00000225206
 .
 3134
 0.4
chr4_81192543_81192855 0.26 FGF5
 fibroblast growth factor 5
 4906
 0.28
chr4_81392876_81393298 0.26 C4orf22
 chromosome 4 open reading frame 22
 136164
 0.05
chr3_112929944_112930573 0.26 BOC
 BOC cell adhesion associated, oncogene regulated
 71
 0.98
chrX_102940107_102940387 0.25 MORF4L2
 mortality factor 4 like 2
 902
 0.43
chr2_238321225_238321570 0.25 COL6A3
 collagen, type VI, alpha 3
 1394
 0.45
chr15_63673315_63673584 0.25 CA12
 carbonic anhydrase XII
 585
 0.82
chr6_139116835_139117557 0.25 ECT2L
 epithelial cell transforming sequence 2 oncogene-like
 61
 0.98
chr4_7873664_7873998 0.25 AFAP1
 actin filament associated protein 1
 22
 0.98
chr2_45396710_45397149 0.25 SIX2
 SIX homeobox 2
 160360
 0.04
chr22_46472803_46473256 0.25 FLJ27365
 hsa-mir-4763
 3163
 0.13
chr19_16179581_16179939 0.25 TPM4
 tropomyosin 4
 1250
 0.44
chr9_112543764_112544054 0.25 AKAP2
 A kinase (PRKA) anchor protein 2
 1140
 0.28
chr7_5634551_5634949 0.25 FSCN1
 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
 433
 0.81
chr6_28175291_28175856 0.25 ZSCAN9
 zinc finger and SCAN domain containing 9
 17091
 0.12
chr15_51386054_51386865 0.25 TNFAIP8L3
 tumor necrosis factor, alpha-induced protein 8-like 3
 11014
 0.22
chr11_19367315_19367499 0.25 NAV2
 neuron navigator 2
 4864
 0.23
chr2_47269894_47270523 0.25 AC093732.1
2545
 0.28
chr7_80548112_80548336 0.25 SEMA3C
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
 275
 0.96
chr6_27205685_27206711 0.24 PRSS16
 protease, serine, 16 (thymus)
 9282
 0.19
chr7_55087572_55088165 0.24 EGFR
 epidermal growth factor receptor
 1057
 0.68
chr3_124604600_124604823 0.24 ITGB5
 integrin, beta 5
 1433
 0.47
chr14_53416235_53416562 0.24 FERMT2
 fermitin family member 2
 888
 0.69
chr3_15837119_15837337 0.24 ANKRD28
 ankyrin repeat domain 28
 800
 0.67
chr3_99357431_99357620 0.24 COL8A1
 collagen, type VIII, alpha 1
 71
 0.98
chr14_30613029_30613261 0.24 PRKD1
 protein kinase D1
 47959
 0.19
chr17_881575_881780 0.24 NXN
 nucleoredoxin
 1333
 0.34
chr14_61104683_61105223 0.24 SIX1
 SIX homeobox 1
 11227
 0.21
chr1_157013915_157014350 0.24 ARHGEF11
 Rho guanine nucleotide exchange factor (GEF) 11
 733
 0.68
chr9_109626964_109627115 0.24 ZNF462
 zinc finger protein 462
 1592
 0.44
chr2_198539523_198539712 0.24 RFTN2
 raftlin family member 2
 1102
 0.51
chr2_66664178_66664750 0.24 MEIS1
 Meis homeobox 1
 61
 0.96
chr8_120685506_120685944 0.24 ENPP2
 ectonucleotide pyrophosphatase/phosphodiesterase 2
 32
 0.98
chr8_18744322_18744566 0.24 PSD3
 pleckstrin and Sec7 domain containing 3
 100
 0.98
chr12_115120954_115121265 0.24 TBX3
 T-box 3
 286
 0.93
chr1_240855293_240855444 0.24 ENSG00000199241
 .
 6252
 0.23
chr8_49833429_49833759 0.24 SNAI2
 snail family zinc finger 2
 394
 0.92
chr6_85823864_85824548 0.24 NT5E
 5'-nucleotidase, ecto (CD73)
 335603
 0.01
chr5_83679357_83679570 0.24 EDIL3
 EGF-like repeats and discoidin I-like domains 3
 741
 0.46
chr9_113799034_113800104 0.24 LPAR1
 lysophosphatidic acid receptor 1
 754
 0.74
chr11_120208718_120208869 0.24 ARHGEF12
 Rho guanine nucleotide exchange factor (GEF) 12
 847
 0.6
chr15_30112674_30113382 0.24 TJP1
 tight junction protein 1
 723
 0.64
chr2_9348603_9349207 0.24 ASAP2
 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
 2011
 0.46
chr1_68084153_68084510 0.23 ENSG00000242482
 .
 38481
 0.16
chr4_81188224_81188744 0.23 FGF5
 fibroblast growth factor 5
 691
 0.76
chr12_125169284_125169605 0.23 NCOR2
 nuclear receptor corepressor 2
 117434
 0.06
chr3_141087883_141088209 0.23 RP11-438D8.2
2067
 0.36
chr21_45006172_45006433 0.23 HSF2BP
 heat shock transcription factor 2 binding protein
 71723
 0.1
chr4_129307789_129307940 0.23 PGRMC2
 progesterone receptor membrane component 2
 97880
 0.09
chr3_25469138_25469713 0.23 RARB
 retinoic acid receptor, beta
 329
 0.93
chr3_138892567_138893067 0.23 MRPS22
 mitochondrial ribosomal protein S22
 63571
 0.12
chr4_126311427_126311944 0.23 FAT4
 FAT atypical cadherin 4
 3406
 0.33
chr3_129407054_129407730 0.23 TMCC1
 transmembrane and coiled-coil domain family 1
 183
 0.96
chr1_185703938_185704134 0.23 HMCN1
 hemicentin 1
 353
 0.92
chr12_47219516_47219750 0.23 SLC38A4
 solute carrier family 38, member 4
 135
 0.98
chr5_82768204_82768925 0.23 VCAN
 versican
 820
 0.75
chr12_72665374_72665945 0.23 ENSG00000236333
 .
 112
 0.93
chr5_162992519_162993506 0.23 MAT2B
 methionine adenosyltransferase II, beta
 60392
 0.11
chr15_80988981_80989242 0.23 ABHD17C
 abhydrolase domain containing 17C
 1459
 0.44
chr2_133998643_133998815 0.23 AC010890.1
23811
 0.24
chr3_159484310_159484461 0.23 IQCJ-SCHIP1
 IQCJ-SCHIP1 readthrough
 1493
 0.34
chr11_79151385_79151576 0.23 TENM4
 teneurin transmembrane protein 4
 215
 0.95
chr4_71996832_71997002 0.23 SLC4A4
 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
 56086
 0.15
chr8_18870397_18870669 0.23 PSD3
 pleckstrin and Sec7 domain containing 3
 663
 0.74
chr7_41735925_41736162 0.23 INHBA-AS1
 INHBA antisense RNA 1
 2497
 0.29
chr6_16200733_16201077 0.22 ENSG00000251831
 .
 4340
 0.21
chr6_85473331_85473901 0.22 TBX18
 T-box 18
 445
 0.9
chr5_78985270_78986298 0.22 CMYA5
 cardiomyopathy associated 5
 84
 0.98
chr18_55889348_55889572 0.22 NEDD4L
 neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
 657
 0.77
chr5_111091378_111091829 0.22 NREP
 neuronal regeneration related protein
 345
 0.9
chr18_57363476_57363657 0.22 RP11-2N1.2
125
 0.93
chr7_132737872_132738088 0.22 CHCHD3
 coiled-coil-helix-coiled-coil-helix domain containing 3
 28820
 0.2
chr18_56244152_56244311 0.22 RP11-126O1.2
19929
 0.14
chr8_13132829_13133895 0.22 DLC1
 deleted in liver cancer 1
 693
 0.78
chr1_67000065_67000303 0.22 SGIP1
 SH3-domain GRB2-like (endophilin) interacting protein 1
 219
 0.96
chr15_96880233_96880461 0.22 ENSG00000222651
 .
 3857
 0.18
chrX_38079311_38080259 0.22 SRPX
 sushi-repeat containing protein, X-linked
 367
 0.75
chr10_6214045_6214449 0.22 ENSG00000263628
 .
 20088
 0.13
chr12_66220556_66220804 0.22 HMGA2
 high mobility group AT-hook 2
 1777
 0.39
chr5_37839467_37839691 0.22 GDNF
 glial cell derived neurotrophic factor
 203
 0.96
chr7_114055343_114055580 0.22 FOXP2
 forkhead box P2
 83
 0.98
chr6_10426220_10426432 0.22 TFAP2A
 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
 6455
 0.18
chr11_27743805_27744092 0.22 BDNF
 brain-derived neurotrophic factor
 343
 0.92
chrX_107178963_107179207 0.22 RP6-191P20.4
125
 0.97
chr1_13910269_13910760 0.22 PDPN
 podoplanin
 74
 0.97
chr3_64671738_64672057 0.22 ADAMTS9-AS2
 ADAMTS9 antisense RNA 2
 1093
 0.46
chr13_33858654_33859881 0.22 STARD13
 StAR-related lipid transfer (START) domain containing 13
 625
 0.76
chr10_24755480_24755818 0.22 KIAA1217
 KIAA1217
 189
 0.96
chr14_42074269_42074448 0.22 LRFN5
 leucine rich repeat and fibronectin type III domain containing 5
 2415
 0.37
chr21_17791847_17792197 0.22 ENSG00000207638
 .
 119387
 0.06
chr20_35169899_35170178 0.21 MYL9
 myosin, light chain 9, regulatory
 138
 0.95
chr5_87988240_87988451 0.21 CTC-467M3.2
123
 0.97
chr6_11229774_11229925 0.21 NEDD9
 neural precursor cell expressed, developmentally down-regulated 9
 3042
 0.32
chr3_180397078_180397946 0.21 CCDC39
 coiled-coil domain containing 39
 224
 0.65
chr18_60153182_60153479 0.21 ZCCHC2
 zinc finger, CCHC domain containing 2
 36910
 0.19
chr7_97952929_97953353 0.21 RP11-307C18.1
976
 0.55
chr20_9049623_9049963 0.21 PLCB4
 phospholipase C, beta 4
 45
 0.98
chr1_101186979_101187209 0.21 VCAM1
 vascular cell adhesion molecule 1
 1774
 0.47
chr11_121969590_121969741 0.21 ENSG00000207971
 .
 887
 0.47
chr11_122044065_122044553 0.21 ENSG00000207994
 .
 21293
 0.17
chr9_94065254_94065575 0.21 AUH
 AU RNA binding protein/enoyl-CoA hydratase
 58763
 0.16
chr18_51736037_51736198 0.21 ENSG00000207233
 .
 12665
 0.21
chr13_21287159_21287369 0.21 ENSG00000265710
 .
 9422
 0.2
chr2_188418224_188418410 0.21 AC007319.1
559
 0.57
chr20_19738276_19738696 0.21 AL121761.2
 Uncharacterized protein
 193
 0.95
chr6_52530050_52530201 0.21 RP1-152L7.5
53
 0.98
chr6_131291045_131291463 0.21 EPB41L2
 erythrocyte membrane protein band 4.1-like 2
 369
 0.93
chr2_167231853_167232143 0.21 SCN9A
 sodium channel, voltage-gated, type IX, alpha subunit
 499
 0.84
chr16_73090314_73090763 0.21 ZFHX3
 zinc finger homeobox 3
 3059
 0.3
chr9_35945444_35945832 0.21 OR2S2
 olfactory receptor, family 2, subfamily S, member 2
 12513
 0.14
chr8_32407136_32407287 0.21 NRG1
 neuregulin 1
 966
 0.71
chr2_158114922_158115143 0.21 GALNT5
 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
 922
 0.66
chr6_138427325_138427625 0.21 PERP
 PERP, TP53 apoptosis effector
 1173
 0.59
chr3_16219029_16219297 0.21 GALNT15
 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
 2947
 0.33
chr8_12989314_12989523 0.21 DLC1
 deleted in liver cancer 1
 1565
 0.46
chr9_93644008_93644159 0.21 SYK
 spleen tyrosine kinase
 54313
 0.18
chr10_33630504_33630927 0.21 NRP1
 neuropilin 1
 5525
 0.29
chr6_114180362_114180910 0.21 MARCKS
 myristoylated alanine-rich protein kinase C substrate
 2095
 0.32
chr8_141625870_141626141 0.21 AGO2
 argonaute RISC catalytic component 2
 10018
 0.24
chr1_227503732_227504041 0.21 CDC42BPA
 CDC42 binding protein kinase alpha (DMPK-like)
 997
 0.69
chr13_33924410_33924807 0.21 STARD13
 StAR-related lipid transfer (START) domain containing 13
 153
 0.97
chr6_114663085_114663750 0.21 HS3ST5
 heparan sulfate (glucosamine) 3-O-sulfotransferase 5
 792
 0.72
chr1_20915430_20915891 0.21 CDA
 cytidine deaminase
 219
 0.93
chr15_90205872_90206267 0.20 PLIN1
 perilipin 1
 4802
 0.14
chr2_138722074_138722590 0.20 HNMT
 histamine N-methyltransferase
 289
 0.95
chr7_89783827_89784376 0.20 STEAP1
 six transmembrane epithelial antigen of the prostate 1
 412
 0.81
chr11_79149207_79149581 0.20 TENM4
 teneurin transmembrane protein 4
 2301
 0.34

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of DBP

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.1 0.4 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.1 0.3 GO:0016576 histone dephosphorylation(GO:0016576)
0.1 0.2 GO:0060841 venous blood vessel development(GO:0060841)
0.1 0.2 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.1 0.3 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.1 0.6 GO:0001946 lymphangiogenesis(GO:0001946) lymph vessel morphogenesis(GO:0036303)
0.1 0.7 GO:0061384 heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.1 0.3 GO:0061364 apoptotic process involved in luteolysis(GO:0061364)
0.1 0.3 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.1 0.3 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.1 0.4 GO:0060008 Sertoli cell differentiation(GO:0060008)
0.1 0.2 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 0.3 GO:0032431 activation of phospholipase A2 activity(GO:0032431)
0.1 0.2 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)
0.1 0.2 GO:0031223 auditory behavior(GO:0031223)
0.1 0.2 GO:0060676 ureteric bud formation(GO:0060676)
0.1 0.2 GO:0070208 protein heterotrimerization(GO:0070208)
0.1 0.3 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.1 0.2 GO:0021615 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.1 0.4 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1 0.4 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1 0.2 GO:0032347 regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.1 0.2 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.1 0.2 GO:1900115 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1 0.1 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.1 0.2 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1 0.1 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.1 0.2 GO:0022605 oogenesis stage(GO:0022605)
0.1 0.7 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 0.2 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.1 0.2 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.1 0.2 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.1 0.4 GO:0071320 cellular response to cAMP(GO:0071320)
0.1 0.1 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.1 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.1 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 0.2 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.1 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.1 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0 0.1 GO:0042339 keratan sulfate metabolic process(GO:0042339)
0.0 0.2 GO:0008218 bioluminescence(GO:0008218)
0.0 0.1 GO:0003308 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0 0.2 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.3 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.2 GO:0061004 pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048)
0.0 0.1 GO:0032236 obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0 0.1 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.0 0.2 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.0 0.1 GO:0050955 thermoception(GO:0050955)
0.0 0.1 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.0 0.6 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.1 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.0 0.1 GO:0051451 myoblast migration(GO:0051451)
0.0 0.2 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.2 GO:0060259 regulation of feeding behavior(GO:0060259)
0.0 0.1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.1 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.2 GO:0006216 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0 0.1 GO:0022617 extracellular matrix disassembly(GO:0022617)
0.0 0.1 GO:0070874 negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.1 GO:0003351 epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.1 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.0 0.1 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.0 0.1 GO:1903521 apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0 0.1 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.1 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.2 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0 0.2 GO:0007494 midgut development(GO:0007494)
0.0 0.1 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0 0.2 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.3 GO:0002675 positive regulation of acute inflammatory response(GO:0002675)
0.0 0.1 GO:0045920 negative regulation of exocytosis(GO:0045920)
0.0 0.1 GO:0090177 establishment of planar polarity involved in neural tube closure(GO:0090177)
0.0 0.0 GO:0043116 negative regulation of vascular permeability(GO:0043116)
0.0 0.1 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.1 GO:0043312 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 0.1 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.2 GO:0001660 fever generation(GO:0001660)
0.0 0.2 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.1 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.1 GO:0051176 positive regulation of sulfur metabolic process(GO:0051176)
0.0 0.1 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.3 GO:0035329 hippo signaling(GO:0035329)
0.0 0.0 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0 0.1 GO:0032455 nerve growth factor processing(GO:0032455)
0.0 0.0 GO:0034201 response to oleic acid(GO:0034201)
0.0 0.1 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.0 0.1 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.2 GO:0008347 glial cell migration(GO:0008347)
0.0 0.1 GO:0060687 regulation of branching involved in prostate gland morphogenesis(GO:0060687)
0.0 0.0 GO:0090400 stress-induced premature senescence(GO:0090400)
0.0 0.1 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.1 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.0 0.1 GO:0009143 nucleoside triphosphate catabolic process(GO:0009143)
0.0 0.2 GO:0043537 negative regulation of blood vessel endothelial cell migration(GO:0043537)
0.0 0.2 GO:0015671 oxygen transport(GO:0015671)
0.0 0.0 GO:0060426 lung vasculature development(GO:0060426)
0.0 0.0 GO:0001840 neural plate morphogenesis(GO:0001839) neural plate development(GO:0001840)
0.0 0.1 GO:0090399 replicative senescence(GO:0090399)
0.0 0.1 GO:0042023 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0 0.0 GO:0051280 negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0 0.1 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.0 0.3 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.1 GO:0043266 regulation of potassium ion transport(GO:0043266)
0.0 0.1 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 0.0 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.1 GO:0046184 aldehyde biosynthetic process(GO:0046184)
0.0 0.1 GO:0014850 response to muscle activity(GO:0014850)
0.0 0.0 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.0 0.3 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.3 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.0 0.1 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.1 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 0.1 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0 0.0 GO:0003032 detection of oxygen(GO:0003032)
0.0 0.1 GO:0002068 glandular epithelial cell development(GO:0002068)
0.0 0.0 GO:0021542 dentate gyrus development(GO:0021542)
0.0 0.0 GO:0060976 coronary vasculature development(GO:0060976)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.1 GO:0060363 cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0 0.1 GO:0032230 positive regulation of synaptic transmission, GABAergic(GO:0032230)
0.0 0.1 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.0 0.4 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.0 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0 0.2 GO:0048566 embryonic digestive tract development(GO:0048566)
0.0 0.0 GO:0007412 axon target recognition(GO:0007412)
0.0 0.1 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.1 GO:0006534 cysteine metabolic process(GO:0006534)
0.0 0.1 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.0 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0 0.1 GO:0051026 chiasma assembly(GO:0051026)
0.0 0.1 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0 0.0 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.1 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.1 GO:0006621 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.1 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.0 GO:2000008 regulation of protein localization to cell surface(GO:2000008)
0.0 0.1 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
0.0 0.0 GO:0060753 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.1 GO:0010107 potassium ion import(GO:0010107)
0.0 0.0 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.0 0.1 GO:0016540 protein autoprocessing(GO:0016540)
0.0 0.0 GO:0051832 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.1 GO:0021591 ventricular system development(GO:0021591)
0.0 0.0 GO:0071470 cellular response to osmotic stress(GO:0071470)
0.0 0.0 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.0 GO:0019511 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0 0.1 GO:0043584 nose development(GO:0043584)
0.0 0.3 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.0 0.0 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.0 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0 0.1 GO:0045176 apical protein localization(GO:0045176)
0.0 0.1 GO:0034644 cellular response to UV(GO:0034644)
0.0 0.0 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.0 0.2 GO:0021766 hippocampus development(GO:0021766)
0.0 0.0 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.0 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.0 GO:0090009 primitive streak formation(GO:0090009)
0.0 0.3 GO:0051101 regulation of DNA binding(GO:0051101)
0.0 0.0 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.1 GO:0001553 luteinization(GO:0001553)
0.0 0.0 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.0 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0 0.1 GO:0006972 hyperosmotic response(GO:0006972)
0.0 0.0 GO:0034421 post-translational protein acetylation(GO:0034421)
0.0 0.1 GO:0030146 obsolete diuresis(GO:0030146)
0.0 0.1 GO:1903428 positive regulation of nitric oxide biosynthetic process(GO:0045429) positive regulation of reactive oxygen species biosynthetic process(GO:1903428) positive regulation of nitric oxide metabolic process(GO:1904407)
0.0 0.0 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0 0.1 GO:0010875 positive regulation of cholesterol efflux(GO:0010875)
0.0 0.0 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.0 GO:0060405 regulation of penile erection(GO:0060405) positive regulation of penile erection(GO:0060406)
0.0 0.1 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.0 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.0 0.0 GO:0046476 glycosylceramide biosynthetic process(GO:0046476)
0.0 0.0 GO:0045901 translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0 0.0 GO:0034629 cellular protein complex localization(GO:0034629)
0.0 0.1 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.0 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.0 0.0 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.0 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 0.1 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.0 GO:0072077 mesenchymal to epithelial transition(GO:0060231) renal vesicle morphogenesis(GO:0072077)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.5 GO:0071437 invadopodium(GO:0071437)
0.1 0.3 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.1 0.4 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.5 GO:0030122 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.1 0.4 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.3 GO:0098642 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.1 GO:0043259 laminin-10 complex(GO:0043259)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.2 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0001940 male pronucleus(GO:0001940)
0.0 0.3 GO:0008091 spectrin(GO:0008091)
0.0 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.2 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.8 GO:0032432 actin filament bundle(GO:0032432)
0.0 0.4 GO:0032589 neuron projection membrane(GO:0032589)
0.0 0.5 GO:0005811 lipid particle(GO:0005811)
0.0 0.1 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.0 0.2 GO:0031941 filamentous actin(GO:0031941)
0.0 0.0 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.2 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.1 GO:0042641 actomyosin(GO:0042641)
0.0 0.1 GO:0014704 intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0 0.1 GO:0032449 CBM complex(GO:0032449)
0.0 0.1 GO:0031512 motile primary cilium(GO:0031512)
0.0 0.5 GO:0030018 Z disc(GO:0030018)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.9 GO:0005604 basement membrane(GO:0005604)
0.0 0.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.1 GO:0036126 outer dense fiber(GO:0001520) sperm flagellum(GO:0036126)
0.0 0.0 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 2.1 GO:0005911 cell-cell junction(GO:0005911)
0.0 0.1 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.0 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.2 GO:0005859 muscle myosin complex(GO:0005859)
0.0 2.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.0 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.1 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0050682 AF-2 domain binding(GO:0050682)
0.1 0.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.3 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.3 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.1 0.2 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.2 GO:0070052 collagen V binding(GO:0070052)
0.1 0.2 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1 0.2 GO:0001098 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1 0.2 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
0.1 0.2 GO:0050544 arachidonic acid binding(GO:0050544)
0.1 0.3 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.2 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.6 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.1 0.2 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.1 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.3 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.2 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.0 0.5 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.2 GO:0008517 folic acid transporter activity(GO:0008517)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.1 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0 0.1 GO:0045118 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0 0.2 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.3 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.1 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0 0.3 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0 0.1 GO:0035198 miRNA binding(GO:0035198)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.4 GO:0030553 cGMP binding(GO:0030553)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.2 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.2 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0030172 troponin C binding(GO:0030172)
0.0 0.2 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.3 GO:0008430 selenium binding(GO:0008430)
0.0 0.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.3 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.1 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.1 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0 0.2 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.2 GO:0016565 obsolete general transcriptional repressor activity(GO:0016565)
0.0 0.1 GO:0008061 chitin binding(GO:0008061)
0.0 0.1 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.1 GO:0004967 glucagon receptor activity(GO:0004967)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.1 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.1 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0 0.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.0 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.1 GO:0070215 obsolete MDM2 binding(GO:0070215)
0.0 0.1 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.1 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.0 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.1 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.2 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.1 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.1 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.2 GO:0016595 glutamate binding(GO:0016595)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.2 GO:0001619 obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.4 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.2 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.1 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.0 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.0 GO:0016151 nickel cation binding(GO:0016151)
0.0 0.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.0 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.1 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.1 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.1 GO:0030955 potassium ion binding(GO:0030955)
0.0 0.1 GO:0031543 peptidyl-proline dioxygenase activity(GO:0031543)
0.0 0.1 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.0 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.0 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.5 GO:0004629 phospholipase C activity(GO:0004629)
0.0 0.1 GO:0004904 interferon receptor activity(GO:0004904)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.1 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0 0.4 GO:0005518 collagen binding(GO:0005518)
0.0 0.0 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.3 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.7 GO:0051015 actin filament binding(GO:0051015)
0.0 0.1 GO:0032552 deoxyribonucleotide binding(GO:0032552)
0.0 0.1 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.2 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.1 GO:0032052 bile acid binding(GO:0032052)
0.0 0.3 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.1 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.0 GO:0008934 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0 0.0 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.0 GO:0045159 myosin II binding(GO:0045159)
0.0 0.1 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 0.2 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.1 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0 0.1 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.1 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0 0.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.1 GO:0001012 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 0.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.0 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.0 GO:0004064 arylesterase activity(GO:0004064)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.6 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.1 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.4 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.2 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.9 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.1 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 0.4 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.1 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.0 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 0.2 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.4 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.4 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.3 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.5 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.1 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.4 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.5 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.1 PID AURORA A PATHWAY Aurora A signaling
0.0 0.5 PID CDC42 PATHWAY CDC42 signaling events
0.0 0.1 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.3 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.2 PID ARF 3PATHWAY Arf1 pathway
0.0 0.1 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.0 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 0.1 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.2 PID PTP1B PATHWAY Signaling events mediated by PTP1B

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 REACTOME SHC MEDIATED SIGNALLING Genes involved in SHC-mediated signalling
0.0 1.3 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.4 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.4 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.1 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.6 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.2 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.3 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.9 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.3 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.2 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.0 0.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.4 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.0 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.0 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.4 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.0 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.0 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.5 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.2 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.1 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.1 REACTOME SIGNALING BY NOTCH3 Genes involved in Signaling by NOTCH3
0.0 0.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions