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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for DBP

Z-value: 1.43

Motif logo

Transcription factors associated with DBP

Gene Symbol	Gene ID	Gene Info
DBP Ensembl NCBI GeneCards UniProt	ENSG00000105516.6	DBP

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
DBP	chr19_49138973_49139430	1308	0.220749	-0.88	1.8e-03	Click!
DBP	chr19_49139505_49139656	1040	0.284260	-0.84	4.8e-03	Click!
DBP	chr19_49139809_49140053	689	0.437960	-0.75	2.0e-02	Click!
DBP	chr19_49140164_49140638	219	0.831467	-0.70	3.4e-02	Click!
DBP	chr19_49133396_49133547	4312	0.088905	0.70	3.6e-02	Click!

Activity of the DBP motif across conditions

Conditions sorted by the z-value of the DBP motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr21_28214648_28215240	0.59	ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif, 1	393	0.9
chrX_30327007_30327420	0.49	NR0B1	nuclear receptor subfamily 0, group B, member 1	282	0.91
chr3_137486919_137487668	0.47	SOX14	SRY (sex determining region Y)-box 14	3714	0.37
chr3_149094469_149095370	0.46	TM4SF1-AS1	TM4SF1 antisense RNA 1	646	0.47
chr7_28725956_28726399	0.45	CREB5	cAMP responsive element binding protein 5	579	0.86
chr1_157980267_157980690	0.44	KIRREL-IT1	KIRREL intronic transcript 1 (non-protein coding)	14862	0.2
chr20_14317720_14318261	0.40	FLRT3	fibronectin leucine rich transmembrane protein 3	264	0.94
chr13_67708586_67709053	0.40	PCDH9	protocadherin 9	93753	0.09
chr6_27560724_27561227	0.40	ENSG00000206671	.	3216	0.27
chr9_14400502_14400713	0.38	NFIB	nuclear factor I/B	1625	0.51
chr5_54456050_54456451	0.36	GPX8	glutathione peroxidase 8 (putative)	252	0.86
chr5_83017716_83018280	0.35	HAPLN1	hyaluronan and proteoglycan link protein 1	566	0.78
chr1_99128119_99128537	0.34	SNX7	sorting nexin 7	549	0.88
chr20_11871763_11872529	0.34	BTBD3	BTB (POZ) domain containing 3	171	0.97
chr5_73110322_73110752	0.34	ARHGEF28	Rho guanine nucleotide exchange factor (GEF) 28	1194	0.51
chr6_19838575_19839711	0.34	RP1-167F1.2		168	0.95
chr13_93879365_93880233	0.33	GPC6	glypican 6	704	0.82
chr7_22538999_22539909	0.33	STEAP1B	STEAP family member 1B	342	0.91
chr6_1821527_1821700	0.32	FOXC1	forkhead box C1	210932	0.02
chr15_39873424_39874712	0.32	THBS1	thrombospondin 1	774	0.66
chr2_164592268_164592669	0.32	FIGN	fidgetin	49	0.99
chr7_94025115_94025296	0.32	COL1A2	collagen, type I, alpha 2	1332	0.57
chr2_106260790_106261225	0.32	NCK2	NCK adaptor protein 2	100347	0.08
chr8_23711881_23712175	0.32	STC1	stanniocalcin 1	204	0.95
chr4_111552866_111553567	0.31	PITX2	paired-like homeodomain 2	4960	0.32
chr12_21652771_21652922	0.31	RECQL	RecQ protein-like (DNA helicase Q1-like)	1639	0.29
chr1_157979860_157980080	0.31	KIRREL-IT1	KIRREL intronic transcript 1 (non-protein coding)	15370	0.2
chr3_64253305_64253544	0.31	PRICKLE2	prickle homolog 2 (Drosophila)	231	0.95
chr12_53443889_53444561	0.31	TENC1	tensin like C1 domain containing phosphatase (tensin 2)	255	0.86
chr2_238322401_238322657	0.31	COL6A3	collagen, type VI, alpha 3	262	0.93
chr15_96869491_96869741	0.30	NR2F2	nuclear receptor subfamily 2, group F, member 2	449	0.57
chr5_38846105_38846894	0.30	OSMR	oncostatin M receptor	398	0.91
chr9_18476160_18476529	0.30	ADAMTSL1	ADAMTS-like 1	2113	0.45
chr18_72509166_72509431	0.29	ZNF407	zinc finger protein 407	166322	0.04
chr6_128828944_128829440	0.29	RP1-86D1.4		2922	0.22
chr7_54972295_54972520	0.29	ENSG00000252054	.	38896	0.2
chr13_38442983_38443134	0.29	TRPC4	transient receptor potential cation channel, subfamily C, member 4	802	0.72
chr16_86603613_86603777	0.29	RP11-463O9.5		2328	0.23
chr1_157964729_157965124	0.29	KIRREL	kin of IRRE like (Drosophila)	1491	0.45
chr2_216296824_216297216	0.29	FN1	fibronectin 1	3770	0.26
chr17_29887718_29887925	0.28	ENSG00000207614	.	806	0.46
chr22_28181066_28181439	0.28	MN1	meningioma (disrupted in balanced translocation) 1	16234	0.25
chr2_46165643_46166035	0.28	PRKCE	protein kinase C, epsilon	62202	0.14
chr3_50395480_50396917	0.28	TMEM115	transmembrane protein 115	843	0.33
chr6_7697968_7698508	0.28	BMP6	bone morphogenetic protein 6	28792	0.23
chr12_120241388_120241613	0.28	CIT	citron (rho-interacting, serine/threonine kinase 21)	313	0.92
chr11_8830922_8831183	0.27	ST5	suppression of tumorigenicity 5	1144	0.43
chr2_119532290_119532494	0.27	EN1	engrailed homeobox 1	72862	0.12
chr13_33543979_33544184	0.27	KL	klotho	46126	0.17
chr9_118918844_118919316	0.27	PAPPA	pregnancy-associated plasma protein A, pappalysin 1	2997	0.34
chr4_124339787_124340099	0.27	SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	18820	0.3
chr19_4575630_4575781	0.27	SEMA6B	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	15885	0.1
chr1_201915320_201915636	0.27	LMOD1	leiomodin 1 (smooth muscle)	237	0.87
chr6_90927639_90927889	0.27	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2	78697	0.1
chr7_139899946_139900413	0.27	ENSG00000199971	.	9292	0.16
chr15_100651358_100651509	0.27	ADAMTS17	ADAM metallopeptidase with thrombospondin type 1 motif, 17	2121	0.32
chr18_71356617_71356768	0.27	ENSG00000241866	.	55478	0.18
chr2_119603311_119603908	0.27	EN1	engrailed homeobox 1	1645	0.51
chr4_188523294_188523560	0.27	ZFP42	ZFP42 zinc finger protein	393498	0.01
chr9_79520083_79520617	0.26	PRUNE2	prune homolog 2 (Drosophila)	651	0.82
chr5_72746721_72747193	0.26	FOXD1	forkhead box D1	2605	0.29
chr1_214397865_214398571	0.26	SMYD2	SET and MYND domain containing 2	56358	0.16
chr4_169553568_169553728	0.26	PALLD	palladin, cytoskeletal associated protein	880	0.63
chr17_13505362_13505866	0.26	HS3ST3A1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	370	0.91
chr18_57326676_57327097	0.26	CCBE1	collagen and calcium binding EGF domains 1	6508	0.21
chr15_59663421_59663716	0.26	FAM81A	family with sequence similarity 81, member A	1324	0.28
chr3_114342653_114342865	0.26	ZBTB20	zinc finger and BTB domain containing 20	294	0.95
chr4_170190156_170190307	0.26	SH3RF1	SH3 domain containing ring finger 1	877	0.72
chr9_91793130_91793737	0.26	SHC3	SHC (Src homology 2 domain containing) transforming protein 3	249	0.95
chr10_104536223_104536534	0.26	WBP1L	WW domain binding protein 1-like	372	0.83
chr20_57089963_57090433	0.26	APCDD1L	adenomatosis polyposis coli down-regulated 1-like	11	0.98
chr3_112354765_112355126	0.26	CCDC80	coiled-coil domain containing 80	1999	0.4
chr8_93113958_93114847	0.26	RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	1052	0.69
chr1_98514742_98514981	0.26	ENSG00000225206	.	3134	0.4
chr4_81192543_81192855	0.26	FGF5	fibroblast growth factor 5	4906	0.28
chr4_81392876_81393298	0.26	C4orf22	chromosome 4 open reading frame 22	136164	0.05
chr3_112929944_112930573	0.26	BOC	BOC cell adhesion associated, oncogene regulated	71	0.98
chrX_102940107_102940387	0.25	MORF4L2	mortality factor 4 like 2	902	0.43
chr2_238321225_238321570	0.25	COL6A3	collagen, type VI, alpha 3	1394	0.45
chr15_63673315_63673584	0.25	CA12	carbonic anhydrase XII	585	0.82
chr6_139116835_139117557	0.25	ECT2L	epithelial cell transforming sequence 2 oncogene-like	61	0.98
chr4_7873664_7873998	0.25	AFAP1	actin filament associated protein 1	22	0.98
chr2_45396710_45397149	0.25	SIX2	SIX homeobox 2	160360	0.04
chr22_46472803_46473256	0.25	FLJ27365	hsa-mir-4763	3163	0.13
chr19_16179581_16179939	0.25	TPM4	tropomyosin 4	1250	0.44
chr9_112543764_112544054	0.25	AKAP2	A kinase (PRKA) anchor protein 2	1140	0.28
chr7_5634551_5634949	0.25	FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	433	0.81
chr6_28175291_28175856	0.25	ZSCAN9	zinc finger and SCAN domain containing 9	17091	0.12
chr15_51386054_51386865	0.25	TNFAIP8L3	tumor necrosis factor, alpha-induced protein 8-like 3	11014	0.22
chr11_19367315_19367499	0.25	NAV2	neuron navigator 2	4864	0.23
chr2_47269894_47270523	0.25	AC093732.1		2545	0.28
chr7_80548112_80548336	0.25	SEMA3C	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	275	0.96
chr6_27205685_27206711	0.24	PRSS16	protease, serine, 16 (thymus)	9282	0.19
chr7_55087572_55088165	0.24	EGFR	epidermal growth factor receptor	1057	0.68
chr3_124604600_124604823	0.24	ITGB5	integrin, beta 5	1433	0.47
chr14_53416235_53416562	0.24	FERMT2	fermitin family member 2	888	0.69
chr3_15837119_15837337	0.24	ANKRD28	ankyrin repeat domain 28	800	0.67
chr3_99357431_99357620	0.24	COL8A1	collagen, type VIII, alpha 1	71	0.98
chr14_30613029_30613261	0.24	PRKD1	protein kinase D1	47959	0.19
chr17_881575_881780	0.24	NXN	nucleoredoxin	1333	0.34
chr14_61104683_61105223	0.24	SIX1	SIX homeobox 1	11227	0.21
chr1_157013915_157014350	0.24	ARHGEF11	Rho guanine nucleotide exchange factor (GEF) 11	733	0.68
chr9_109626964_109627115	0.24	ZNF462	zinc finger protein 462	1592	0.44
chr2_198539523_198539712	0.24	RFTN2	raftlin family member 2	1102	0.51
chr2_66664178_66664750	0.24	MEIS1	Meis homeobox 1	61	0.96
chr8_120685506_120685944	0.24	ENPP2	ectonucleotide pyrophosphatase/phosphodiesterase 2	32	0.98
chr8_18744322_18744566	0.24	PSD3	pleckstrin and Sec7 domain containing 3	100	0.98
chr12_115120954_115121265	0.24	TBX3	T-box 3	286	0.93
chr1_240855293_240855444	0.24	ENSG00000199241	.	6252	0.23
chr8_49833429_49833759	0.24	SNAI2	snail family zinc finger 2	394	0.92
chr6_85823864_85824548	0.24	NT5E	5'-nucleotidase, ecto (CD73)	335603	0.01
chr5_83679357_83679570	0.24	EDIL3	EGF-like repeats and discoidin I-like domains 3	741	0.46
chr9_113799034_113800104	0.24	LPAR1	lysophosphatidic acid receptor 1	754	0.74
chr11_120208718_120208869	0.24	ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	847	0.6
chr15_30112674_30113382	0.24	TJP1	tight junction protein 1	723	0.64
chr2_9348603_9349207	0.24	ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	2011	0.46
chr1_68084153_68084510	0.23	ENSG00000242482	.	38481	0.16
chr4_81188224_81188744	0.23	FGF5	fibroblast growth factor 5	691	0.76
chr12_125169284_125169605	0.23	NCOR2	nuclear receptor corepressor 2	117434	0.06
chr3_141087883_141088209	0.23	RP11-438D8.2		2067	0.36
chr21_45006172_45006433	0.23	HSF2BP	heat shock transcription factor 2 binding protein	71723	0.1
chr4_129307789_129307940	0.23	PGRMC2	progesterone receptor membrane component 2	97880	0.09
chr3_25469138_25469713	0.23	RARB	retinoic acid receptor, beta	329	0.93
chr3_138892567_138893067	0.23	MRPS22	mitochondrial ribosomal protein S22	63571	0.12
chr4_126311427_126311944	0.23	FAT4	FAT atypical cadherin 4	3406	0.33
chr3_129407054_129407730	0.23	TMCC1	transmembrane and coiled-coil domain family 1	183	0.96
chr1_185703938_185704134	0.23	HMCN1	hemicentin 1	353	0.92
chr12_47219516_47219750	0.23	SLC38A4	solute carrier family 38, member 4	135	0.98
chr5_82768204_82768925	0.23	VCAN	versican	820	0.75
chr12_72665374_72665945	0.23	ENSG00000236333	.	112	0.93
chr5_162992519_162993506	0.23	MAT2B	methionine adenosyltransferase II, beta	60392	0.11
chr15_80988981_80989242	0.23	ABHD17C	abhydrolase domain containing 17C	1459	0.44
chr2_133998643_133998815	0.23	AC010890.1		23811	0.24
chr3_159484310_159484461	0.23	IQCJ-SCHIP1	IQCJ-SCHIP1 readthrough	1493	0.34
chr11_79151385_79151576	0.23	TENM4	teneurin transmembrane protein 4	215	0.95
chr4_71996832_71997002	0.23	SLC4A4	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	56086	0.15
chr8_18870397_18870669	0.23	PSD3	pleckstrin and Sec7 domain containing 3	663	0.74
chr7_41735925_41736162	0.23	INHBA-AS1	INHBA antisense RNA 1	2497	0.29
chr6_16200733_16201077	0.22	ENSG00000251831	.	4340	0.21
chr6_85473331_85473901	0.22	TBX18	T-box 18	445	0.9
chr5_78985270_78986298	0.22	CMYA5	cardiomyopathy associated 5	84	0.98
chr18_55889348_55889572	0.22	NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	657	0.77
chr5_111091378_111091829	0.22	NREP	neuronal regeneration related protein	345	0.9
chr18_57363476_57363657	0.22	RP11-2N1.2		125	0.93
chr7_132737872_132738088	0.22	CHCHD3	coiled-coil-helix-coiled-coil-helix domain containing 3	28820	0.2
chr18_56244152_56244311	0.22	RP11-126O1.2		19929	0.14
chr8_13132829_13133895	0.22	DLC1	deleted in liver cancer 1	693	0.78
chr1_67000065_67000303	0.22	SGIP1	SH3-domain GRB2-like (endophilin) interacting protein 1	219	0.96
chr15_96880233_96880461	0.22	ENSG00000222651	.	3857	0.18
chrX_38079311_38080259	0.22	SRPX	sushi-repeat containing protein, X-linked	367	0.75
chr10_6214045_6214449	0.22	ENSG00000263628	.	20088	0.13
chr12_66220556_66220804	0.22	HMGA2	high mobility group AT-hook 2	1777	0.39
chr5_37839467_37839691	0.22	GDNF	glial cell derived neurotrophic factor	203	0.96
chr7_114055343_114055580	0.22	FOXP2	forkhead box P2	83	0.98
chr6_10426220_10426432	0.22	TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	6455	0.18
chr11_27743805_27744092	0.22	BDNF	brain-derived neurotrophic factor	343	0.92
chrX_107178963_107179207	0.22	RP6-191P20.4		125	0.97
chr1_13910269_13910760	0.22	PDPN	podoplanin	74	0.97
chr3_64671738_64672057	0.22	ADAMTS9-AS2	ADAMTS9 antisense RNA 2	1093	0.46
chr13_33858654_33859881	0.22	STARD13	StAR-related lipid transfer (START) domain containing 13	625	0.76
chr10_24755480_24755818	0.22	KIAA1217	KIAA1217	189	0.96
chr14_42074269_42074448	0.22	LRFN5	leucine rich repeat and fibronectin type III domain containing 5	2415	0.37
chr21_17791847_17792197	0.22	ENSG00000207638	.	119387	0.06
chr20_35169899_35170178	0.21	MYL9	myosin, light chain 9, regulatory	138	0.95
chr5_87988240_87988451	0.21	CTC-467M3.2		123	0.97
chr6_11229774_11229925	0.21	NEDD9	neural precursor cell expressed, developmentally down-regulated 9	3042	0.32
chr3_180397078_180397946	0.21	CCDC39	coiled-coil domain containing 39	224	0.65
chr18_60153182_60153479	0.21	ZCCHC2	zinc finger, CCHC domain containing 2	36910	0.19
chr7_97952929_97953353	0.21	RP11-307C18.1		976	0.55
chr20_9049623_9049963	0.21	PLCB4	phospholipase C, beta 4	45	0.98
chr1_101186979_101187209	0.21	VCAM1	vascular cell adhesion molecule 1	1774	0.47
chr11_121969590_121969741	0.21	ENSG00000207971	.	887	0.47
chr11_122044065_122044553	0.21	ENSG00000207994	.	21293	0.17
chr9_94065254_94065575	0.21	AUH	AU RNA binding protein/enoyl-CoA hydratase	58763	0.16
chr18_51736037_51736198	0.21	ENSG00000207233	.	12665	0.21
chr13_21287159_21287369	0.21	ENSG00000265710	.	9422	0.2
chr2_188418224_188418410	0.21	AC007319.1		559	0.57
chr20_19738276_19738696	0.21	AL121761.2	Uncharacterized protein	193	0.95
chr6_52530050_52530201	0.21	RP1-152L7.5		53	0.98
chr6_131291045_131291463	0.21	EPB41L2	erythrocyte membrane protein band 4.1-like 2	369	0.93
chr2_167231853_167232143	0.21	SCN9A	sodium channel, voltage-gated, type IX, alpha subunit	499	0.84
chr16_73090314_73090763	0.21	ZFHX3	zinc finger homeobox 3	3059	0.3
chr9_35945444_35945832	0.21	OR2S2	olfactory receptor, family 2, subfamily S, member 2	12513	0.14
chr8_32407136_32407287	0.21	NRG1	neuregulin 1	966	0.71
chr2_158114922_158115143	0.21	GALNT5	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)	922	0.66
chr6_138427325_138427625	0.21	PERP	PERP, TP53 apoptosis effector	1173	0.59
chr3_16219029_16219297	0.21	GALNT15	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15	2947	0.33
chr8_12989314_12989523	0.21	DLC1	deleted in liver cancer 1	1565	0.46
chr9_93644008_93644159	0.21	SYK	spleen tyrosine kinase	54313	0.18
chr10_33630504_33630927	0.21	NRP1	neuropilin 1	5525	0.29
chr6_114180362_114180910	0.21	MARCKS	myristoylated alanine-rich protein kinase C substrate	2095	0.32
chr8_141625870_141626141	0.21	AGO2	argonaute RISC catalytic component 2	10018	0.24
chr1_227503732_227504041	0.21	CDC42BPA	CDC42 binding protein kinase alpha (DMPK-like)	997	0.69
chr13_33924410_33924807	0.21	STARD13	StAR-related lipid transfer (START) domain containing 13	153	0.97
chr6_114663085_114663750	0.21	HS3ST5	heparan sulfate (glucosamine) 3-O-sulfotransferase 5	792	0.72
chr1_20915430_20915891	0.21	CDA	cytidine deaminase	219	0.93
chr15_90205872_90206267	0.20	PLIN1	perilipin 1	4802	0.14
chr2_138722074_138722590	0.20	HNMT	histamine N-methyltransferase	289	0.95
chr7_89783827_89784376	0.20	STEAP1	six transmembrane epithelial antigen of the prostate 1	412	0.81
chr11_79149207_79149581	0.20	TENM4	teneurin transmembrane protein 4	2301	0.34

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of DBP

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.1	0.4	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.1	0.3	GO:0016576	histone dephosphorylation(GO:0016576)
0.1	0.2	GO:0060841	venous blood vessel development(GO:0060841)
0.1	0.2	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.1	0.3	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.1	0.6	GO:0001946	lymphangiogenesis(GO:0001946) lymph vessel morphogenesis(GO:0036303)
0.1	0.7	GO:0061384	heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.1	0.3	GO:0061364	apoptotic process involved in luteolysis(GO:0061364)
0.1	0.3	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.1	0.3	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.1	0.4	GO:0060008	Sertoli cell differentiation(GO:0060008)
0.1	0.2	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.1	0.3	GO:0032431	activation of phospholipase A2 activity(GO:0032431)
0.1	0.2	GO:0051895	negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)
0.1	0.2	GO:0031223	auditory behavior(GO:0031223)
0.1	0.2	GO:0060676	ureteric bud formation(GO:0060676)
0.1	0.2	GO:0070208	protein heterotrimerization(GO:0070208)
0.1	0.3	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.1	0.2	GO:0021615	glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.1	0.4	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1	0.4	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1	0.2	GO:0032347	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.1	0.2	GO:0007207	phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.1	0.2	GO:1900115	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.1	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.1	0.2	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1	0.1	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.1	0.2	GO:0022605	oogenesis stage(GO:0022605)
0.1	0.7	GO:0002089	lens morphogenesis in camera-type eye(GO:0002089)
0.1	0.2	GO:0048755	branching morphogenesis of a nerve(GO:0048755)
0.1	0.2	GO:0050774	negative regulation of dendrite morphogenesis(GO:0050774)
0.1	0.2	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.1	0.4	GO:0071320	cellular response to cAMP(GO:0071320)
0.1	0.1	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.1	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.1	0.1	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1	0.2	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1	0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.1	GO:0045198	establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0	0.1	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.2	GO:0008218	bioluminescence(GO:0008218)
0.0	0.1	GO:0003308	negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0	0.2	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.3	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.2	GO:0061004	pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048)
0.0	0.1	GO:0032236	obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0	0.1	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.2	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.1	GO:0050955	thermoception(GO:0050955)
0.0	0.1	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.6	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.1	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.1	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.2	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.2	GO:0060259	regulation of feeding behavior(GO:0060259)
0.0	0.1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
0.0	0.2	GO:0006216	cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0	0.1	GO:0022617	extracellular matrix disassembly(GO:0022617)
0.0	0.1	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.1	GO:0003351	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.1	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.0	0.1	GO:0061029	eyelid development in camera-type eye(GO:0061029)
0.0	0.1	GO:1903521	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0	0.1	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.2	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.2	GO:0007494	midgut development(GO:0007494)
0.0	0.1	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.2	GO:1904893	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.3	GO:0002675	positive regulation of acute inflammatory response(GO:0002675)
0.0	0.1	GO:0045920	negative regulation of exocytosis(GO:0045920)
0.0	0.1	GO:0090177	establishment of planar polarity involved in neural tube closure(GO:0090177)
0.0	0.0	GO:0043116	negative regulation of vascular permeability(GO:0043116)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.1	GO:0043312	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0	0.1	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.2	GO:0001660	fever generation(GO:0001660)
0.0	0.2	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.1	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
0.0	0.1	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.0	0.1	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.3	GO:0035329	hippo signaling(GO:0035329)
0.0	0.0	GO:0032227	negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0	0.1	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.0	GO:0034201	response to oleic acid(GO:0034201)
0.0	0.1	GO:0045663	positive regulation of myoblast differentiation(GO:0045663)
0.0	0.1	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.0	0.2	GO:0008347	glial cell migration(GO:0008347)
0.0	0.1	GO:0060687	regulation of branching involved in prostate gland morphogenesis(GO:0060687)
0.0	0.0	GO:0090400	stress-induced premature senescence(GO:0090400)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0021631	optic nerve morphogenesis(GO:0021631)
0.0	0.1	GO:0009143	nucleoside triphosphate catabolic process(GO:0009143)
0.0	0.2	GO:0043537	negative regulation of blood vessel endothelial cell migration(GO:0043537)
0.0	0.2	GO:0015671	oxygen transport(GO:0015671)
0.0	0.0	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.0	GO:0001840	neural plate morphogenesis(GO:0001839) neural plate development(GO:0001840)
0.0	0.1	GO:0090399	replicative senescence(GO:0090399)
0.0	0.1	GO:0042023	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.0	GO:0051280	negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0	0.1	GO:0097154	GABAergic neuron differentiation(GO:0097154)
0.0	0.3	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.0	0.1	GO:0043266	regulation of potassium ion transport(GO:0043266)
0.0	0.1	GO:0017187	peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0	0.0	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0046184	aldehyde biosynthetic process(GO:0046184)
0.0	0.1	GO:0014850	response to muscle activity(GO:0014850)
0.0	0.0	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.0	0.3	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
0.0	0.3	GO:0035249	synaptic transmission, glutamatergic(GO:0035249)
0.0	0.1	GO:0042501	serine phosphorylation of STAT protein(GO:0042501)
0.0	0.1	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0	0.1	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.0	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.1	GO:0002068	glandular epithelial cell development(GO:0002068)
0.0	0.0	GO:0021542	dentate gyrus development(GO:0021542)
0.0	0.0	GO:0060976	coronary vasculature development(GO:0060976)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.1	GO:0060363	cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0	0.1	GO:0032230	positive regulation of synaptic transmission, GABAergic(GO:0032230)
0.0	0.1	GO:0030917	midbrain-hindbrain boundary development(GO:0030917)
0.0	0.4	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.0	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0	0.2	GO:0048566	embryonic digestive tract development(GO:0048566)
0.0	0.0	GO:0007412	axon target recognition(GO:0007412)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.1	GO:0006534	cysteine metabolic process(GO:0006534)
0.0	0.1	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0	0.0	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.1	GO:0051026	chiasma assembly(GO:0051026)
0.0	0.1	GO:2000258	negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0	0.0	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.1	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.1	GO:0006621	protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.1	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.0	0.0	GO:2000008	regulation of protein localization to cell surface(GO:2000008)
0.0	0.1	GO:0010633	negative regulation of epithelial cell migration(GO:0010633)
0.0	0.0	GO:0060753	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0	0.1	GO:0010107	potassium ion import(GO:0010107)
0.0	0.0	GO:0045835	negative regulation of meiotic nuclear division(GO:0045835)
0.0	0.1	GO:0016540	protein autoprocessing(GO:0016540)
0.0	0.0	GO:0051832	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.1	GO:0021591	ventricular system development(GO:0021591)
0.0	0.0	GO:0071470	cellular response to osmotic stress(GO:0071470)
0.0	0.0	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.0	GO:0019511	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0	0.1	GO:0043584	nose development(GO:0043584)
0.0	0.3	GO:0090090	negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.0	0.0	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.0	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.1	GO:0045176	apical protein localization(GO:0045176)
0.0	0.1	GO:0034644	cellular response to UV(GO:0034644)
0.0	0.0	GO:0010765	positive regulation of sodium ion transport(GO:0010765)
0.0	0.2	GO:0021766	hippocampus development(GO:0021766)
0.0	0.0	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.0	GO:0000733	DNA strand renaturation(GO:0000733)
0.0	0.0	GO:0090009	primitive streak formation(GO:0090009)
0.0	0.3	GO:0051101	regulation of DNA binding(GO:0051101)
0.0	0.0	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.1	GO:0001553	luteinization(GO:0001553)
0.0	0.0	GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0	0.0	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0	0.1	GO:0006972	hyperosmotic response(GO:0006972)
0.0	0.0	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.1	GO:0030146	obsolete diuresis(GO:0030146)
0.0	0.1	GO:1903428	positive regulation of nitric oxide biosynthetic process(GO:0045429) positive regulation of reactive oxygen species biosynthetic process(GO:1903428) positive regulation of nitric oxide metabolic process(GO:1904407)
0.0	0.0	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0	0.1	GO:0010875	positive regulation of cholesterol efflux(GO:0010875)
0.0	0.0	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.0	GO:0060405	regulation of penile erection(GO:0060405) positive regulation of penile erection(GO:0060406)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.0	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
0.0	0.0	GO:0046476	glycosylceramide biosynthetic process(GO:0046476)
0.0	0.0	GO:0045901	translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0	0.0	GO:0034629	cellular protein complex localization(GO:0034629)
0.0	0.1	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.0	0.0	GO:0032148	activation of protein kinase B activity(GO:0032148)
0.0	0.0	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.0	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	0.1	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.0	GO:0072077	mesenchymal to epithelial transition(GO:0060231) renal vesicle morphogenesis(GO:0072077)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	0.5	GO:0071437	invadopodium(GO:0071437)
0.1	0.3	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.1	0.4	GO:0042788	polysomal ribosome(GO:0042788)
0.1	0.5	GO:0030122	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.1	0.4	GO:0005577	fibrinogen complex(GO:0005577)
0.1	0.3	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.3	GO:0098642	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.1	GO:0043259	laminin-10 complex(GO:0043259)
0.0	0.1	GO:0070852	cell body fiber(GO:0070852)
0.0	0.2	GO:0016342	catenin complex(GO:0016342)
0.0	0.1	GO:0001940	male pronucleus(GO:0001940)
0.0	0.3	GO:0008091	spectrin(GO:0008091)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.2	GO:0031527	filopodium membrane(GO:0031527)
0.0	0.8	GO:0032432	actin filament bundle(GO:0032432)
0.0	0.4	GO:0032589	neuron projection membrane(GO:0032589)
0.0	0.5	GO:0005811	lipid particle(GO:0005811)
0.0	0.1	GO:0030132	clathrin coat of coated pit(GO:0030132)
0.0	0.2	GO:0031941	filamentous actin(GO:0031941)
0.0	0.0	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.2	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.1	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.1	GO:0042641	actomyosin(GO:0042641)
0.0	0.1	GO:0014704	intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0	0.1	GO:0032449	CBM complex(GO:0032449)
0.0	0.1	GO:0031512	motile primary cilium(GO:0031512)
0.0	0.5	GO:0030018	Z disc(GO:0030018)
0.0	0.1	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.1	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.9	GO:0005604	basement membrane(GO:0005604)
0.0	0.2	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.0	0.1	GO:0036126	outer dense fiber(GO:0001520) sperm flagellum(GO:0036126)
0.0	0.0	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.1	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.0	2.1	GO:0005911	cell-cell junction(GO:0005911)
0.0	0.1	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.0	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.2	GO:0005859	muscle myosin complex(GO:0005859)
0.0	2.5	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.0	0.0	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.1	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.0	0.1	GO:0000782	telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0050682	AF-2 domain binding(GO:0050682)
0.1	0.3	GO:0030215	semaphorin receptor binding(GO:0030215)
0.1	0.3	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.3	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.1	0.2	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.2	GO:0070052	collagen V binding(GO:0070052)
0.1	0.2	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1	0.2	GO:0001098	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.2	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.1	0.2	GO:0050544	arachidonic acid binding(GO:0050544)
0.1	0.3	GO:0070700	BMP receptor binding(GO:0070700)
0.1	0.2	GO:0003680	AT DNA binding(GO:0003680)
0.1	0.6	GO:0034483	heparan sulfate sulfotransferase activity(GO:0034483)
0.1	0.2	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.1	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.3	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.2	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.5	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.0	0.2	GO:0008517	folic acid transporter activity(GO:0008517)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.1	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.1	GO:0045118	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.2	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.2	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.2	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.3	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.1	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.3	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.1	GO:0035198	miRNA binding(GO:0035198)
0.0	0.2	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.6	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	0.2	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.4	GO:0030553	cGMP binding(GO:0030553)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0046923	ER retention sequence binding(GO:0046923)
0.0	0.6	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.2	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.4	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.0	0.2	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0030172	troponin C binding(GO:0030172)
0.0	0.2	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.3	GO:0008430	selenium binding(GO:0008430)
0.0	0.2	GO:0004126	cytidine deaminase activity(GO:0004126)
0.0	0.3	GO:0005003	ephrin receptor activity(GO:0005003)
0.0	0.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.1	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.1	GO:0019797	procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0	0.2	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.1	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.2	GO:0016565	obsolete general transcriptional repressor activity(GO:0016565)
0.0	0.1	GO:0008061	chitin binding(GO:0008061)
0.0	0.1	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.1	GO:0004967	glucagon receptor activity(GO:0004967)
0.0	0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.1	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.1	GO:0043140	ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0	0.5	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.0	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.1	GO:0070215	obsolete MDM2 binding(GO:0070215)
0.0	0.1	GO:1900750	glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0	0.1	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.1	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.1	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.0	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.1	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.3	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.0	0.1	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0	0.2	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.1	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.1	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.1	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.2	GO:0016595	glutamate binding(GO:0016595)
0.0	0.1	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.2	GO:0001619	obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0	0.1	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.4	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.2	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.2	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0	0.1	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.3	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	0.0	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.0	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.2	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	0.0	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.1	GO:0017081	chloride channel regulator activity(GO:0017081)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.1	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.1	GO:0031543	peptidyl-proline dioxygenase activity(GO:0031543)
0.0	0.1	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.0	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.0	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.5	GO:0004629	phospholipase C activity(GO:0004629)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.1	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0	0.4	GO:0005518	collagen binding(GO:0005518)
0.0	0.0	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.3	GO:0017147	Wnt-protein binding(GO:0017147)
0.0	0.7	GO:0051015	actin filament binding(GO:0051015)
0.0	0.1	GO:0032552	deoxyribonucleotide binding(GO:0032552)
0.0	0.1	GO:0004745	retinol dehydrogenase activity(GO:0004745)
0.0	0.9	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	0.2	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.1	GO:0032052	bile acid binding(GO:0032052)
0.0	0.3	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.0	0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.0	GO:0008934	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.0	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)
0.0	0.0	GO:0045159	myosin II binding(GO:0045159)
0.0	0.1	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.0	0.2	GO:1905030	voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0	0.1	GO:0000832	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0	0.1	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.1	GO:0004022	alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0	0.0	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.1	GO:0001012	RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0	0.4	GO:0008307	structural constituent of muscle(GO:0008307)
0.0	0.0	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.0	GO:0004064	arylesterase activity(GO:0004064)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.7	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.6	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.4	ST G ALPHA S PATHWAY	G alpha s Pathway
0.2	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.9	NABA COLLAGENS	Genes encoding collagen proteins
0.7	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.8	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.1	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.4	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	ST B CELL ANTIGEN RECEPTOR	B Cell Antigen Receptor
0.2	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.6	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.4	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.4	PID ARF6 PATHWAY	Arf6 signaling events
0.3	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.4	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.2	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.5	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.4	PID EPHA FWDPATHWAY	EPHA forward signaling
0.5	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1	PID AURORA A PATHWAY	Aurora A signaling
0.5	PID CDC42 PATHWAY	CDC42 signaling events
0.1	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.3	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.2	PID ARF 3PATHWAY	Arf1 pathway
0.1	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.1	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.2	PID PTP1B PATHWAY	Signaling events mediated by PTP1B

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	REACTOME SHC MEDIATED SIGNALLING	Genes involved in SHC-mediated signalling
0.0	1.3	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	0.4	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.0	0.4	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.1	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	0.8	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.3	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.6	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	0.6	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.3	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.0	0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.3	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.3	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0	0.9	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.0	0.3	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.2	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
0.0	0.2	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.0	0.4	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.0	0.0	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.0	0.2	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.0	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.3	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.4	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.0	0.0	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.0	0.2	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.2	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.0	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.5	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.2	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	0.2	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.0	0.1	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.1	REACTOME SIGNALING BY NOTCH3	Genes involved in Signaling by NOTCH3
0.0	0.2	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions