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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for DDIT3

Z-value: 0.90

Motif logo

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Transcription factors associated with DDIT3

Gene Symbol Gene ID Gene Info
DDIT3
ENSG00000175197.6 DNA damage inducible transcript 3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr12_57913983_57914218DDIT31750.663482-0.235.5e-01Click!

Activity of the DDIT3 motif across conditions

Conditions sorted by the z-value of the DDIT3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr1_36948102_36948314 0.68 CSF3R
 colony stimulating factor 3 receptor (granulocyte)
 556
 0.73
chr20_54987227_54988129 0.46 CASS4
 Cas scaffolding protein family member 4
 361
 0.82
chr13_111314544_111314695 0.43 CARS2
 cysteinyl-tRNA synthetase 2, mitochondrial (putative)
 14752
 0.2
chr13_31312260_31312411 0.42 ALOX5AP
 arachidonate 5-lipoxygenase-activating protein
 2690
 0.38
chr22_37679801_37680063 0.39 CYTH4
 cytohesin 4
 1404
 0.39
chr11_121324494_121324645 0.39 RP11-730K11.1
847
 0.59
chr19_16259637_16259788 0.37 HSH2D
 hematopoietic SH2 domain containing
 5166
 0.13
chr5_39217983_39218134 0.37 FYB
 FYN binding protein
 1607
 0.52
chr2_175532806_175532957 0.36 WIPF1
 WAS/WASL interacting protein family, member 1
 14718
 0.23
chr12_25207113_25207806 0.32 LRMP
 lymphoid-restricted membrane protein
 1785
 0.37
chr17_25609205_25609356 0.31 ENSG00000263583
 .
 11742
 0.23
chr22_50523508_50523892 0.31 MLC1
 megalencephalic leukoencephalopathy with subcortical cysts 1
 12
 0.97
chr3_196361762_196362043 0.31 LINC01063
 long intergenic non-protein coding RNA 1063
 2444
 0.19
chr1_111416540_111416879 0.31 CD53
 CD53 molecule
 933
 0.59
chr17_57803272_57803423 0.30 VMP1
 vacuole membrane protein 1
 3729
 0.21
chr16_57076639_57076877 0.30 NLRC5
 NLR family, CARD domain containing 5
 15219
 0.13
chr13_46752366_46752713 0.29 LCP1
 lymphocyte cytosolic protein 1 (L-plastin)
 3920
 0.19
chr8_134151695_134151846 0.29 TG
 thyroglobulin
 26023
 0.18
chr5_71768722_71768873 0.29 RP11-389C8.2
30583
 0.19
chr1_17956706_17956857 0.29 ARHGEF10L
 Rho guanine nucleotide exchange factor (GEF) 10-like
 11932
 0.27
chr1_248020847_248021774 0.29 TRIM58
 tripartite motif containing 58
 809
 0.49
chr10_11218203_11218399 0.28 RP3-323N1.2
4962
 0.24
chr8_142131426_142131715 0.28 DENND3
 DENN/MADD domain containing 3
 4193
 0.23
chr21_36280824_36280975 0.28 RUNX1
 runt-related transcription factor 1
 18812
 0.28
chr6_144655565_144656031 0.26 RP1-91J24.3
1361
 0.51
chr2_111801445_111801596 0.26 ACOXL
 acyl-CoA oxidase-like
 56745
 0.14
chr6_24922511_24922662 0.26 FAM65B
 family with sequence similarity 65, member B
 11391
 0.23
chr17_45743155_45743306 0.26 KPNB1
 karyopherin (importin) beta 1
 2501
 0.2
chr1_198612556_198613143 0.25 PTPRC
 protein tyrosine phosphatase, receptor type, C
 4557
 0.28
chr12_7060265_7060416 0.25 PTPN6
 protein tyrosine phosphatase, non-receptor type 6
 85
 0.9
chr2_145340979_145341178 0.24 ZEB2
 zinc finger E-box binding homeobox 2
 62457
 0.14
chrX_9431281_9431551 0.24 TBL1X
 transducin (beta)-like 1X-linked
 45
 0.99
chr15_39745852_39746003 0.24 RP11-624L4.1
26531
 0.23
chr6_34330915_34331066 0.24 NUDT3
 nudix (nucleoside diphosphate linked moiety X)-type motif 3
 29461
 0.16
chr19_41303975_41304672 0.24 EGLN2
 egl-9 family hypoxia-inducible factor 2
 578
 0.64
chr11_12146032_12146187 0.23 MICAL2
 microtubule associated monooxygenase, calponin and LIM domain containing 2
 3087
 0.36
chr5_75697779_75697971 0.23 IQGAP2
 IQ motif containing GTPase activating protein 2
 1199
 0.61
chr6_131895116_131895267 0.23 ARG1
 arginase 1
 826
 0.65
chr10_63819340_63819491 0.23 ARID5B
 AT rich interactive domain 5B (MRF1-like)
 10445
 0.27
chr9_134148708_134148859 0.22 FAM78A
 family with sequence similarity 78, member A
 2873
 0.24
chr1_192515169_192515320 0.22 RP5-1011O1.2
21103
 0.19
chr3_99791321_99791472 0.22 FILIP1L
 filamin A interacting protein 1-like
 41961
 0.15
chr4_185373022_185373173 0.22 ENSG00000251878
 .
 19977
 0.17
chr10_73520322_73520473 0.22 C10orf54
 chromosome 10 open reading frame 54
 3010
 0.26
chr20_34356216_34356461 0.22 ENSG00000222152
 .
 1451
 0.3
chr2_197104668_197104938 0.22 AC020571.3
19945
 0.17
chr11_48075840_48075991 0.22 AC103828.1
38508
 0.15
chr15_86098266_86098417 0.22 AKAP13
 A kinase (PRKA) anchor protein 13
 336
 0.89
chr2_161423396_161423547 0.20 RBMS1
 RNA binding motif, single stranded interacting protein 1
 73166
 0.12
chr19_13206703_13207270 0.20 LYL1
 lymphoblastic leukemia derived sequence 1
 6695
 0.11
chr17_40423913_40424064 0.20 AC003104.1
599
 0.6
chr2_201934315_201934539 0.20 NDUFB3
 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
 1729
 0.24
chr1_160681036_160681588 0.20 CD48
 CD48 molecule
 281
 0.89
chr8_61821706_61823076 0.20 RP11-33I11.2
100226
 0.08
chr13_33608099_33608250 0.20 ENSG00000221677
 .
 7315
 0.24
chr10_6969023_6969174 0.20 PRKCQ
 protein kinase C, theta
 346835
 0.01
chr18_60939286_60939489 0.20 RP11-28F1.2
41928
 0.13
chr8_11681660_11681811 0.19 FDFT1
 farnesyl-diphosphate farnesyltransferase 1
 14970
 0.13
chr20_30198550_30198775 0.19 ENSG00000264395
 .
 3673
 0.14
chr9_134150778_134151758 0.19 FAM78A
 family with sequence similarity 78, member A
 666
 0.69
chr6_86353352_86354469 0.19 SYNCRIP
 synaptotagmin binding, cytoplasmic RNA interacting protein
 400
 0.85
chr2_143886362_143886549 0.19 ARHGAP15
 Rho GTPase activating protein 15
 428
 0.89
chr5_172232754_172232905 0.19 ENSG00000206741
 .
 25732
 0.13
chr8_134086469_134086645 0.19 SLA
 Src-like-adaptor
 13954
 0.23
chr2_32784349_32784500 0.19 ENSG00000207653
 .
 27204
 0.2
chrX_38665177_38665418 0.19 MID1IP1-AS1
 MID1IP1 antisense RNA 1
 2161
 0.33
chr9_79252333_79252484 0.19 PRUNE2
 prune homolog 2 (Drosophila)
 15057
 0.21
chr6_24937107_24937405 0.19 FAM65B
 family with sequence similarity 65, member B
 1068
 0.59
chr5_17445932_17446083 0.19 ENSG00000201715
 .
 100282
 0.08
chr1_180133242_180133393 0.18 QSOX1
 quiescin Q6 sulfhydryl oxidase 1
 9285
 0.24
chr2_153469359_153469510 0.18 FMNL2
 formin-like 2
 6658
 0.31
chr2_46072609_46072760 0.18 PRKCE
 protein kinase C, epsilon
 155357
 0.04
chr4_185773586_185773737 0.18 ENSG00000266698
 .
 1397
 0.43
chr2_135004109_135004260 0.18 MGAT5
 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
 7646
 0.25
chr9_113065636_113065787 0.18 TXNDC8
 thioredoxin domain containing 8 (spermatozoa)
 34377
 0.16
chr2_37844682_37844833 0.18 AC006369.2
17478
 0.22
chr12_10281805_10282201 0.18 CLEC7A
 C-type lectin domain family 7, member A
 678
 0.6
chr12_11803481_11804350 0.18 ETV6
 ets variant 6
 1127
 0.62
chr20_50267564_50267715 0.18 NFATC2
 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
 88269
 0.09
chr10_76092336_76092487 0.18 ADK
 adenosine kinase
 155890
 0.04
chr17_68166405_68166607 0.18 KCNJ2
 potassium inwardly-rectifying channel, subfamily J, member 2
 830
 0.45
chr1_40629914_40630065 0.17 RLF
 rearranged L-myc fusion
 2944
 0.23
chr18_13464392_13464543 0.17 LDLRAD4
 low density lipoprotein receptor class A domain containing 4
 547
 0.62
chr12_32113291_32114105 0.17 KIAA1551
 KIAA1551
 1345
 0.51
chr22_40858929_40859404 0.17 MKL1
 megakaryoblastic leukemia (translocation) 1
 256
 0.92
chr1_246870680_246870831 0.17 SCCPDH
 saccharopine dehydrogenase (putative)
 16594
 0.19
chr2_169458585_169458736 0.17 ENSG00000199348
 .
 4346
 0.26
chr16_31207787_31207938 0.17 RP11-388M20.1
410
 0.64
chr1_183549635_183549786 0.17 NCF2
 neutrophil cytosolic factor 2
 10006
 0.2
chr1_184127977_184128128 0.17 ENSG00000199840
 .
 12905
 0.26
chr5_136949485_136949636 0.17 ENSG00000216009
 .
 33778
 0.18
chr2_8519851_8520002 0.16 AC011747.7
295970
 0.01
chr9_101870409_101870560 0.16 TGFBR1
 transforming growth factor, beta receptor 1
 3052
 0.29
chr11_65059695_65060120 0.16 POLA2
 polymerase (DNA directed), alpha 2, accessory subunit
 9929
 0.12
chr11_10480131_10480282 0.16 AMPD3
 adenosine monophosphate deaminase 3
 2473
 0.29
chr6_159483193_159483344 0.16 TAGAP
 T-cell activation RhoGTPase activating protein
 17084
 0.19
chr1_112017238_112017517 0.16 C1orf162
 chromosome 1 open reading frame 162
 886
 0.41
chr10_21501235_21501386 0.16 NEBL-AS1
 NEBL antisense RNA 1
 38027
 0.16
chr8_64181080_64181231 0.16 ENSG00000241964
 .
 33686
 0.22
chr18_4862576_4862727 0.16 ENSG00000222463
 .
 125517
 0.06
chr4_177754947_177755098 0.16 VEGFC
 vascular endothelial growth factor C
 41141
 0.21
chr20_61200398_61200730 0.16 ENSG00000207764
 .
 38445
 0.09
chr12_15699901_15700074 0.16 PTPRO
 protein tyrosine phosphatase, receptor type, O
 701
 0.8
chr3_128722868_128723019 0.16 EFCC1
 EF-hand and coiled-coil domain containing 1
 2471
 0.22
chr4_12125602_12125753 0.16 ENSG00000266669
 .
 110612
 0.08
chr13_100059124_100059288 0.16 ENSG00000266207
 .
 46517
 0.12
chr17_68316942_68317093 0.16 KCNJ2
 potassium inwardly-rectifying channel, subfamily J, member 2
 151341
 0.04
chr7_92776252_92776403 0.16 SAMD9L
 sterile alpha motif domain containing 9-like
 1331
 0.49
chr21_35917446_35917660 0.15 RCAN1
 regulator of calcineurin 1
 14924
 0.2
chr10_63818920_63819071 0.15 ARID5B
 AT rich interactive domain 5B (MRF1-like)
 10025
 0.27
chr12_104324193_104325484 0.15 ENSG00000265072
 .
 635
 0.44
chr22_45772663_45772814 0.15 SMC1B
 structural maintenance of chromosomes 1B
 36710
 0.13
chr20_10486029_10486187 0.15 SLX4IP
 SLX4 interacting protein
 70157
 0.11
chr19_2253059_2253418 0.15 JSRP1
 junctional sarcoplasmic reticulum protein 1
 2110
 0.13
chr16_87093858_87094180 0.15 RP11-899L11.3
155502
 0.04
chr13_99909010_99909161 0.15 GPR18
 G protein-coupled receptor 18
 1543
 0.41
chr4_156597025_156597176 0.15 GUCY1A3
 guanylate cyclase 1, soluble, alpha 3
 8285
 0.26
chr17_71965951_71966102 0.15 RPL38
 ribosomal protein L38
 233695
 0.02
chr7_38670068_38671048 0.15 AMPH
 amphiphysin
 462
 0.87
chr6_14355345_14355496 0.15 ENSG00000238987
 .
 198727
 0.03
chr16_55608580_55608731 0.15 CAPNS2
 calpain, small subunit 2
 8071
 0.24
chrX_117672480_117672631 0.15 ENSG00000206862
 .
 30923
 0.19
chr12_32742619_32742910 0.15 FGD4
 FYVE, RhoGEF and PH domain containing 4
 8696
 0.27
chr6_144606475_144607358 0.15 UTRN
 utrophin
 79
 0.98
chr2_176399969_176400120 0.14 ENSG00000221347
 .
 204943
 0.02
chr7_7221124_7221275 0.14 C1GALT1
 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
 979
 0.6
chr15_63780195_63780346 0.14 USP3
 ubiquitin specific peptidase 3
 16523
 0.23
chr10_115604050_115604207 0.14 DCLRE1A
 DNA cross-link repair 1A
 9731
 0.17
chr7_150414088_150414577 0.14 GIMAP1
 GTPase, IMAP family member 1
 687
 0.65
chr1_169580216_169580367 0.14 SELP
 selectin P (granule membrane protein 140kDa, antigen CD62)
 8166
 0.21
chr5_139989047_139989276 0.14 CD14
 CD14 molecule
 24075
 0.07
chr1_208091875_208092026 0.14 CD34
 CD34 molecule
 7203
 0.31
chr19_35837974_35838249 0.14 ENSG00000263397
 .
 1695
 0.19
chr2_113589955_113590106 0.14 IL1B
 interleukin 1, beta
 3981
 0.2
chr11_1872722_1872911 0.14 LSP1
 lymphocyte-specific protein 1
 1384
 0.25
chr14_52313408_52314007 0.14 GNG2
 guanine nucleotide binding protein (G protein), gamma 2
 137
 0.97
chr6_12128420_12128571 0.14 HIVEP1
 human immunodeficiency virus type I enhancer binding protein 1
 2516
 0.42
chr3_141121365_141121859 0.14 ZBTB38
 zinc finger and BTB domain containing 38
 48
 0.98
chr10_20117593_20117744 0.14 PLXDC2
 plexin domain containing 2
 12500
 0.2
chr15_52844361_52844512 0.14 ARPP19
 cAMP-regulated phosphoprotein, 19kDa
 5505
 0.2
chr1_36521425_36521576 0.14 TEKT2
 tektin 2 (testicular)
 28176
 0.13
chr18_21594952_21595765 0.14 RP11-403A21.2
55
 0.94
chr13_53542376_53542527 0.14 OLFM4
 olfactomedin 4
 60443
 0.14
chr2_134876082_134876233 0.14 MGAT5
 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
 1596
 0.46
chr22_46988879_46989444 0.14 GRAMD4
 GRAM domain containing 4
 16135
 0.21
chr1_212781685_212782134 0.14 ATF3
 activating transcription factor 3
 103
 0.96
chr19_16372792_16372943 0.14 CTD-2562J15.6
31519
 0.12
chr14_22593025_22593176 0.14 ENSG00000238634
 .
 17787
 0.27
chr2_207565040_207565191 0.14 ENSG00000207319
 .
 794
 0.61
chr8_121822100_121822251 0.13 SNTB1
 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
 2208
 0.3
chr1_160611300_160611550 0.13 SLAMF1
 signaling lymphocytic activation molecule family member 1
 5386
 0.18
chr6_37770727_37770878 0.13 RP3-441A12.1
16192
 0.18
chr7_130597934_130598170 0.13 ENSG00000226380
 .
 35754
 0.19
chr19_57349494_57349674 0.13 ZIM2
 zinc finger, imprinted 2
 2138
 0.28
chr13_99964812_99964963 0.13 GPR183
 G protein-coupled receptor 183
 5228
 0.22
chr1_41827168_41827846 0.13 FOXO6
 forkhead box O6
 87
 0.98
chr10_3710614_3710914 0.13 RP11-184A2.3
82495
 0.1
chrY_1342944_1343095 0.13 NA
 NA
 > 106
 NA
chrX_1392949_1393100 0.13 CSF2RA
 colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
 5286
 0.11
chr7_26141990_26142141 0.13 ENSG00000266430
 .
 42106
 0.14
chr14_51280333_51280548 0.13 RP11-286O18.1
8158
 0.15
chr7_104581843_104582295 0.13 ENSG00000251911
 .
 29665
 0.15
chr3_113467764_113467962 0.13 ATP6V1A
 ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
 1966
 0.3
chrX_46509501_46509746 0.13 CHST7
 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
 76404
 0.1
chr1_243646030_243646536 0.13 RP11-269F20.1
62551
 0.14
chr10_119165300_119165451 0.13 PDZD8
 PDZ domain containing 8
 30397
 0.18
chr5_7879366_7879517 0.13 MTRR
 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
 9067
 0.2
chr5_134695220_134695371 0.13 C5orf66
 chromosome 5 open reading frame 66
 21666
 0.16
chr13_95133005_95133156 0.12 DCT
 dopachrome tautomerase
 1144
 0.56
chr19_16229742_16229926 0.12 RAB8A
 RAB8A, member RAS oncogene family
 7127
 0.13
chr16_11208681_11208920 0.12 CLEC16A
 C-type lectin domain family 16, member A
 8800
 0.2
chr21_15914846_15914997 0.12 SAMSN1
 SAM domain, SH3 domain and nuclear localization signals 1
 3741
 0.3
chr8_37966919_37967070 0.12 ASH2L
 ash2 (absent, small, or homeotic)-like (Drosophila)
 3537
 0.14
chr10_11183987_11184138 0.12 CELF2
 CUGBP, Elav-like family member 2
 22931
 0.18
chr6_155545887_155546038 0.12 TIAM2
 T-cell lymphoma invasion and metastasis 2
 7862
 0.22
chr12_65032414_65032565 0.12 RP11-338E21.2
10365
 0.12
chr11_2290287_2290803 0.12 ASCL2
 achaete-scute family bHLH transcription factor 2
 1637
 0.29
chr17_10018080_10018535 0.12 GAS7
 growth arrest-specific 7
 437
 0.85
chr4_105982764_105983024 0.12 ENSG00000252136
 .
 44250
 0.17
chr3_71626106_71626306 0.12 FOXP1-IT1
 FOXP1 intronic transcript 1 (non-protein coding)
 2598
 0.29
chr6_163826222_163826373 0.12 QKI
 QKI, KH domain containing, RNA binding
 9378
 0.32
chr14_65521176_65521327 0.12 ENSG00000266531
 .
 9845
 0.14
chr8_141124879_141125135 0.12 C8orf17
 chromosome 8 open reading frame 17
 181591
 0.03
chr3_16883275_16883542 0.12 PLCL2
 phospholipase C-like 2
 43044
 0.19
chr2_30371809_30371960 0.12 YPEL5
 yippee-like 5 (Drosophila)
 1502
 0.4
chr20_52198944_52199193 0.12 ZNF217
 zinc finger protein 217
 568
 0.75
chr2_208004362_208004513 0.12 KLF7
 Kruppel-like factor 7 (ubiquitous)
 5576
 0.21
chr4_184580518_184581453 0.12 TRAPPC11
 trafficking protein particle complex 11
 539
 0.46
chr17_27466417_27467105 0.12 MYO18A
 myosin XVIIIA
 675
 0.43
chr1_19642719_19642870 0.11 ENSG00000265192
 .
 3760
 0.13
chr15_64747923_64748074 0.11 ZNF609
 zinc finger protein 609
 4943
 0.14
chr20_43104144_43104478 0.11 TTPAL
 tocopherol (alpha) transfer protein-like
 215
 0.89
chrX_55282426_55282577 0.11 PAGE3
 P antigen family, member 3 (prostate associated)
 8662
 0.21
chr1_33472964_33473115 0.11 RP1-117O3.2
20363
 0.13
chr8_126398781_126398932 0.11 RP11-550A5.2
35198
 0.17
chr10_45956119_45956270 0.11 RP11-67C2.2
7625
 0.26
chr3_46508059_46508210 0.11 LTF
 lactotransferrin
 1481
 0.36
chr5_76361780_76361931 0.11 CTC-564N23.2
7851
 0.14
chr7_128580814_128580965 0.11 IRF5
 interferon regulatory factor 5
 163
 0.94
chr2_136871413_136871564 0.11 CXCR4
 chemokine (C-X-C motif) receptor 4
 2325
 0.41

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of DDIT3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0002540 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0 0.2 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0 0.1 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.2 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.1 GO:0015917 aminophospholipid transport(GO:0015917)
0.0 0.1 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.1 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0 0.1 GO:0045056 transcytosis(GO:0045056)
0.0 0.1 GO:0032817 regulation of natural killer cell proliferation(GO:0032817)
0.0 0.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.1 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.1 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.1 GO:0002691 regulation of cellular extravasation(GO:0002691)
0.0 0.1 GO:0036465 synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0 0.1 GO:0070672 response to interleukin-15(GO:0070672)
0.0 0.1 GO:0018106 peptidyl-histidine phosphorylation(GO:0018106)
0.0 0.1 GO:0052308 pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308)
0.0 0.1 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.3 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:0001821 histamine secretion(GO:0001821)
0.0 0.1 GO:1901797 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0 0.1 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.0 0.1 GO:0034616 response to laminar fluid shear stress(GO:0034616)
0.0 0.3 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.0 0.0 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309)
0.0 0.1 GO:0042520 tyrosine phosphorylation of Stat4 protein(GO:0042504) regulation of tyrosine phosphorylation of Stat4 protein(GO:0042519) positive regulation of tyrosine phosphorylation of Stat4 protein(GO:0042520)
0.0 0.0 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.0 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.3 GO:0060330 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 0.0 GO:0042494 detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0 0.0 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.0 0.1 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.0 GO:0006106 fumarate metabolic process(GO:0006106)
0.0 0.1 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.1 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.0 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.0 0.0 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0 0.1 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.0 GO:0033591 response to L-ascorbic acid(GO:0033591)
0.0 0.0 GO:0010626 regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626)
0.0 0.1 GO:0071318 cellular response to ATP(GO:0071318)
0.0 0.0 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.1 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.0 GO:0015959 diadenosine polyphosphate metabolic process(GO:0015959)
0.0 0.0 GO:0034139 regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0 0.1 GO:0051319 mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0 0.0 GO:0036336 dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0 0.0 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.0 GO:0007042 lysosomal lumen acidification(GO:0007042) regulation of lysosomal lumen pH(GO:0035751)
0.0 0.0 GO:0002019 regulation of renal output by angiotensin(GO:0002019)
0.0 0.0 GO:0071379 cellular response to prostaglandin stimulus(GO:0071379)
0.0 0.0 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.0 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.3 GO:0000299 obsolete integral to membrane of membrane fraction(GO:0000299)
0.0 0.1 GO:0001740 Barr body(GO:0001740)
0.0 0.1 GO:0042583 chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.0 0.1 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0050544 arachidonic acid binding(GO:0050544)
0.0 0.5 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.1 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.1 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.0 0.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0001846 opsonin binding(GO:0001846)
0.0 0.1 GO:0042156 obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0 0.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.1 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.0 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.1 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0 0.1 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.0 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.3 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.1 GO:0052743 inositol tetrakisphosphate phosphatase activity(GO:0052743)
0.0 0.0 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 0.1 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.1 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.1 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.1 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.1 GO:0051400 BH domain binding(GO:0051400)
0.0 0.0 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.0 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.1 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.1 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.0 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.2 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 0.6 GO:0004896 cytokine receptor activity(GO:0004896)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.7 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.2 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.2 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.2 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.2 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.1 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation