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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for DDIT3

Z-value: 0.90

Motif logo

Transcription factors associated with DDIT3

Gene Symbol	Gene ID	Gene Info
DDIT3 Ensembl NCBI GeneCards UniProt	ENSG00000175197.6	DDIT3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
DDIT3	chr12_57913983_57914218	175	0.663482	-0.23	5.5e-01	Click!

Activity of the DDIT3 motif across conditions

Conditions sorted by the z-value of the DDIT3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_36948102_36948314	0.68	CSF3R	colony stimulating factor 3 receptor (granulocyte)	556	0.73
chr20_54987227_54988129	0.46	CASS4	Cas scaffolding protein family member 4	361	0.82
chr13_111314544_111314695	0.43	CARS2	cysteinyl-tRNA synthetase 2, mitochondrial (putative)	14752	0.2
chr13_31312260_31312411	0.42	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	2690	0.38
chr22_37679801_37680063	0.39	CYTH4	cytohesin 4	1404	0.39
chr11_121324494_121324645	0.39	RP11-730K11.1		847	0.59
chr19_16259637_16259788	0.37	HSH2D	hematopoietic SH2 domain containing	5166	0.13
chr5_39217983_39218134	0.37	FYB	FYN binding protein	1607	0.52
chr2_175532806_175532957	0.36	WIPF1	WAS/WASL interacting protein family, member 1	14718	0.23
chr12_25207113_25207806	0.32	LRMP	lymphoid-restricted membrane protein	1785	0.37
chr17_25609205_25609356	0.31	ENSG00000263583	.	11742	0.23
chr22_50523508_50523892	0.31	MLC1	megalencephalic leukoencephalopathy with subcortical cysts 1	12	0.97
chr3_196361762_196362043	0.31	LINC01063	long intergenic non-protein coding RNA 1063	2444	0.19
chr1_111416540_111416879	0.31	CD53	CD53 molecule	933	0.59
chr17_57803272_57803423	0.30	VMP1	vacuole membrane protein 1	3729	0.21
chr16_57076639_57076877	0.30	NLRC5	NLR family, CARD domain containing 5	15219	0.13
chr13_46752366_46752713	0.29	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	3920	0.19
chr8_134151695_134151846	0.29	TG	thyroglobulin	26023	0.18
chr5_71768722_71768873	0.29	RP11-389C8.2		30583	0.19
chr1_17956706_17956857	0.29	ARHGEF10L	Rho guanine nucleotide exchange factor (GEF) 10-like	11932	0.27
chr1_248020847_248021774	0.29	TRIM58	tripartite motif containing 58	809	0.49
chr10_11218203_11218399	0.28	RP3-323N1.2		4962	0.24
chr8_142131426_142131715	0.28	DENND3	DENN/MADD domain containing 3	4193	0.23
chr21_36280824_36280975	0.28	RUNX1	runt-related transcription factor 1	18812	0.28
chr6_144655565_144656031	0.26	RP1-91J24.3		1361	0.51
chr2_111801445_111801596	0.26	ACOXL	acyl-CoA oxidase-like	56745	0.14
chr6_24922511_24922662	0.26	FAM65B	family with sequence similarity 65, member B	11391	0.23
chr17_45743155_45743306	0.26	KPNB1	karyopherin (importin) beta 1	2501	0.2
chr1_198612556_198613143	0.25	PTPRC	protein tyrosine phosphatase, receptor type, C	4557	0.28
chr12_7060265_7060416	0.25	PTPN6	protein tyrosine phosphatase, non-receptor type 6	85	0.9
chr2_145340979_145341178	0.24	ZEB2	zinc finger E-box binding homeobox 2	62457	0.14
chrX_9431281_9431551	0.24	TBL1X	transducin (beta)-like 1X-linked	45	0.99
chr15_39745852_39746003	0.24	RP11-624L4.1		26531	0.23
chr6_34330915_34331066	0.24	NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	29461	0.16
chr19_41303975_41304672	0.24	EGLN2	egl-9 family hypoxia-inducible factor 2	578	0.64
chr11_12146032_12146187	0.23	MICAL2	microtubule associated monooxygenase, calponin and LIM domain containing 2	3087	0.36
chr5_75697779_75697971	0.23	IQGAP2	IQ motif containing GTPase activating protein 2	1199	0.61
chr6_131895116_131895267	0.23	ARG1	arginase 1	826	0.65
chr10_63819340_63819491	0.23	ARID5B	AT rich interactive domain 5B (MRF1-like)	10445	0.27
chr9_134148708_134148859	0.22	FAM78A	family with sequence similarity 78, member A	2873	0.24
chr1_192515169_192515320	0.22	RP5-1011O1.2		21103	0.19
chr3_99791321_99791472	0.22	FILIP1L	filamin A interacting protein 1-like	41961	0.15
chr4_185373022_185373173	0.22	ENSG00000251878	.	19977	0.17
chr10_73520322_73520473	0.22	C10orf54	chromosome 10 open reading frame 54	3010	0.26
chr20_34356216_34356461	0.22	ENSG00000222152	.	1451	0.3
chr2_197104668_197104938	0.22	AC020571.3		19945	0.17
chr11_48075840_48075991	0.22	AC103828.1		38508	0.15
chr15_86098266_86098417	0.22	AKAP13	A kinase (PRKA) anchor protein 13	336	0.89
chr2_161423396_161423547	0.20	RBMS1	RNA binding motif, single stranded interacting protein 1	73166	0.12
chr19_13206703_13207270	0.20	LYL1	lymphoblastic leukemia derived sequence 1	6695	0.11
chr17_40423913_40424064	0.20	AC003104.1		599	0.6
chr2_201934315_201934539	0.20	NDUFB3	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa	1729	0.24
chr1_160681036_160681588	0.20	CD48	CD48 molecule	281	0.89
chr8_61821706_61823076	0.20	RP11-33I11.2		100226	0.08
chr13_33608099_33608250	0.20	ENSG00000221677	.	7315	0.24
chr10_6969023_6969174	0.20	PRKCQ	protein kinase C, theta	346835	0.01
chr18_60939286_60939489	0.20	RP11-28F1.2		41928	0.13
chr8_11681660_11681811	0.19	FDFT1	farnesyl-diphosphate farnesyltransferase 1	14970	0.13
chr20_30198550_30198775	0.19	ENSG00000264395	.	3673	0.14
chr9_134150778_134151758	0.19	FAM78A	family with sequence similarity 78, member A	666	0.69
chr6_86353352_86354469	0.19	SYNCRIP	synaptotagmin binding, cytoplasmic RNA interacting protein	400	0.85
chr2_143886362_143886549	0.19	ARHGAP15	Rho GTPase activating protein 15	428	0.89
chr5_172232754_172232905	0.19	ENSG00000206741	.	25732	0.13
chr8_134086469_134086645	0.19	SLA	Src-like-adaptor	13954	0.23
chr2_32784349_32784500	0.19	ENSG00000207653	.	27204	0.2
chrX_38665177_38665418	0.19	MID1IP1-AS1	MID1IP1 antisense RNA 1	2161	0.33
chr9_79252333_79252484	0.19	PRUNE2	prune homolog 2 (Drosophila)	15057	0.21
chr6_24937107_24937405	0.19	FAM65B	family with sequence similarity 65, member B	1068	0.59
chr5_17445932_17446083	0.19	ENSG00000201715	.	100282	0.08
chr1_180133242_180133393	0.18	QSOX1	quiescin Q6 sulfhydryl oxidase 1	9285	0.24
chr2_153469359_153469510	0.18	FMNL2	formin-like 2	6658	0.31
chr2_46072609_46072760	0.18	PRKCE	protein kinase C, epsilon	155357	0.04
chr4_185773586_185773737	0.18	ENSG00000266698	.	1397	0.43
chr2_135004109_135004260	0.18	MGAT5	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	7646	0.25
chr9_113065636_113065787	0.18	TXNDC8	thioredoxin domain containing 8 (spermatozoa)	34377	0.16
chr2_37844682_37844833	0.18	AC006369.2		17478	0.22
chr12_10281805_10282201	0.18	CLEC7A	C-type lectin domain family 7, member A	678	0.6
chr12_11803481_11804350	0.18	ETV6	ets variant 6	1127	0.62
chr20_50267564_50267715	0.18	NFATC2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	88269	0.09
chr10_76092336_76092487	0.18	ADK	adenosine kinase	155890	0.04
chr17_68166405_68166607	0.18	KCNJ2	potassium inwardly-rectifying channel, subfamily J, member 2	830	0.45
chr1_40629914_40630065	0.17	RLF	rearranged L-myc fusion	2944	0.23
chr18_13464392_13464543	0.17	LDLRAD4	low density lipoprotein receptor class A domain containing 4	547	0.62
chr12_32113291_32114105	0.17	KIAA1551	KIAA1551	1345	0.51
chr22_40858929_40859404	0.17	MKL1	megakaryoblastic leukemia (translocation) 1	256	0.92
chr1_246870680_246870831	0.17	SCCPDH	saccharopine dehydrogenase (putative)	16594	0.19
chr2_169458585_169458736	0.17	ENSG00000199348	.	4346	0.26
chr16_31207787_31207938	0.17	RP11-388M20.1		410	0.64
chr1_183549635_183549786	0.17	NCF2	neutrophil cytosolic factor 2	10006	0.2
chr1_184127977_184128128	0.17	ENSG00000199840	.	12905	0.26
chr5_136949485_136949636	0.17	ENSG00000216009	.	33778	0.18
chr2_8519851_8520002	0.16	AC011747.7		295970	0.01
chr9_101870409_101870560	0.16	TGFBR1	transforming growth factor, beta receptor 1	3052	0.29
chr11_65059695_65060120	0.16	POLA2	polymerase (DNA directed), alpha 2, accessory subunit	9929	0.12
chr11_10480131_10480282	0.16	AMPD3	adenosine monophosphate deaminase 3	2473	0.29
chr6_159483193_159483344	0.16	TAGAP	T-cell activation RhoGTPase activating protein	17084	0.19
chr1_112017238_112017517	0.16	C1orf162	chromosome 1 open reading frame 162	886	0.41
chr10_21501235_21501386	0.16	NEBL-AS1	NEBL antisense RNA 1	38027	0.16
chr8_64181080_64181231	0.16	ENSG00000241964	.	33686	0.22
chr18_4862576_4862727	0.16	ENSG00000222463	.	125517	0.06
chr4_177754947_177755098	0.16	VEGFC	vascular endothelial growth factor C	41141	0.21
chr20_61200398_61200730	0.16	ENSG00000207764	.	38445	0.09
chr12_15699901_15700074	0.16	PTPRO	protein tyrosine phosphatase, receptor type, O	701	0.8
chr3_128722868_128723019	0.16	EFCC1	EF-hand and coiled-coil domain containing 1	2471	0.22
chr4_12125602_12125753	0.16	ENSG00000266669	.	110612	0.08
chr13_100059124_100059288	0.16	ENSG00000266207	.	46517	0.12
chr17_68316942_68317093	0.16	KCNJ2	potassium inwardly-rectifying channel, subfamily J, member 2	151341	0.04
chr7_92776252_92776403	0.16	SAMD9L	sterile alpha motif domain containing 9-like	1331	0.49
chr21_35917446_35917660	0.15	RCAN1	regulator of calcineurin 1	14924	0.2
chr10_63818920_63819071	0.15	ARID5B	AT rich interactive domain 5B (MRF1-like)	10025	0.27
chr12_104324193_104325484	0.15	ENSG00000265072	.	635	0.44
chr22_45772663_45772814	0.15	SMC1B	structural maintenance of chromosomes 1B	36710	0.13
chr20_10486029_10486187	0.15	SLX4IP	SLX4 interacting protein	70157	0.11
chr19_2253059_2253418	0.15	JSRP1	junctional sarcoplasmic reticulum protein 1	2110	0.13
chr16_87093858_87094180	0.15	RP11-899L11.3		155502	0.04
chr13_99909010_99909161	0.15	GPR18	G protein-coupled receptor 18	1543	0.41
chr4_156597025_156597176	0.15	GUCY1A3	guanylate cyclase 1, soluble, alpha 3	8285	0.26
chr17_71965951_71966102	0.15	RPL38	ribosomal protein L38	233695	0.02
chr7_38670068_38671048	0.15	AMPH	amphiphysin	462	0.87
chr6_14355345_14355496	0.15	ENSG00000238987	.	198727	0.03
chr16_55608580_55608731	0.15	CAPNS2	calpain, small subunit 2	8071	0.24
chrX_117672480_117672631	0.15	ENSG00000206862	.	30923	0.19
chr12_32742619_32742910	0.15	FGD4	FYVE, RhoGEF and PH domain containing 4	8696	0.27
chr6_144606475_144607358	0.15	UTRN	utrophin	79	0.98
chr2_176399969_176400120	0.14	ENSG00000221347	.	204943	0.02
chr7_7221124_7221275	0.14	C1GALT1	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1	979	0.6
chr15_63780195_63780346	0.14	USP3	ubiquitin specific peptidase 3	16523	0.23
chr10_115604050_115604207	0.14	DCLRE1A	DNA cross-link repair 1A	9731	0.17
chr7_150414088_150414577	0.14	GIMAP1	GTPase, IMAP family member 1	687	0.65
chr1_169580216_169580367	0.14	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	8166	0.21
chr5_139989047_139989276	0.14	CD14	CD14 molecule	24075	0.07
chr1_208091875_208092026	0.14	CD34	CD34 molecule	7203	0.31
chr19_35837974_35838249	0.14	ENSG00000263397	.	1695	0.19
chr2_113589955_113590106	0.14	IL1B	interleukin 1, beta	3981	0.2
chr11_1872722_1872911	0.14	LSP1	lymphocyte-specific protein 1	1384	0.25
chr14_52313408_52314007	0.14	GNG2	guanine nucleotide binding protein (G protein), gamma 2	137	0.97
chr6_12128420_12128571	0.14	HIVEP1	human immunodeficiency virus type I enhancer binding protein 1	2516	0.42
chr3_141121365_141121859	0.14	ZBTB38	zinc finger and BTB domain containing 38	48	0.98
chr10_20117593_20117744	0.14	PLXDC2	plexin domain containing 2	12500	0.2
chr15_52844361_52844512	0.14	ARPP19	cAMP-regulated phosphoprotein, 19kDa	5505	0.2
chr1_36521425_36521576	0.14	TEKT2	tektin 2 (testicular)	28176	0.13
chr18_21594952_21595765	0.14	RP11-403A21.2		55	0.94
chr13_53542376_53542527	0.14	OLFM4	olfactomedin 4	60443	0.14
chr2_134876082_134876233	0.14	MGAT5	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	1596	0.46
chr22_46988879_46989444	0.14	GRAMD4	GRAM domain containing 4	16135	0.21
chr1_212781685_212782134	0.14	ATF3	activating transcription factor 3	103	0.96
chr19_16372792_16372943	0.14	CTD-2562J15.6		31519	0.12
chr14_22593025_22593176	0.14	ENSG00000238634	.	17787	0.27
chr2_207565040_207565191	0.14	ENSG00000207319	.	794	0.61
chr8_121822100_121822251	0.13	SNTB1	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)	2208	0.3
chr1_160611300_160611550	0.13	SLAMF1	signaling lymphocytic activation molecule family member 1	5386	0.18
chr6_37770727_37770878	0.13	RP3-441A12.1		16192	0.18
chr7_130597934_130598170	0.13	ENSG00000226380	.	35754	0.19
chr19_57349494_57349674	0.13	ZIM2	zinc finger, imprinted 2	2138	0.28
chr13_99964812_99964963	0.13	GPR183	G protein-coupled receptor 183	5228	0.22
chr1_41827168_41827846	0.13	FOXO6	forkhead box O6	87	0.98
chr10_3710614_3710914	0.13	RP11-184A2.3		82495	0.1
chrY_1342944_1343095	0.13	NA	NA	> 10⁶	NA
chrX_1392949_1393100	0.13	CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	5286	0.11
chr7_26141990_26142141	0.13	ENSG00000266430	.	42106	0.14
chr14_51280333_51280548	0.13	RP11-286O18.1		8158	0.15
chr7_104581843_104582295	0.13	ENSG00000251911	.	29665	0.15
chr3_113467764_113467962	0.13	ATP6V1A	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A	1966	0.3
chrX_46509501_46509746	0.13	CHST7	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7	76404	0.1
chr1_243646030_243646536	0.13	RP11-269F20.1		62551	0.14
chr10_119165300_119165451	0.13	PDZD8	PDZ domain containing 8	30397	0.18
chr5_7879366_7879517	0.13	MTRR	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	9067	0.2
chr5_134695220_134695371	0.13	C5orf66	chromosome 5 open reading frame 66	21666	0.16
chr13_95133005_95133156	0.12	DCT	dopachrome tautomerase	1144	0.56
chr19_16229742_16229926	0.12	RAB8A	RAB8A, member RAS oncogene family	7127	0.13
chr16_11208681_11208920	0.12	CLEC16A	C-type lectin domain family 16, member A	8800	0.2
chr21_15914846_15914997	0.12	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	3741	0.3
chr8_37966919_37967070	0.12	ASH2L	ash2 (absent, small, or homeotic)-like (Drosophila)	3537	0.14
chr10_11183987_11184138	0.12	CELF2	CUGBP, Elav-like family member 2	22931	0.18
chr6_155545887_155546038	0.12	TIAM2	T-cell lymphoma invasion and metastasis 2	7862	0.22
chr12_65032414_65032565	0.12	RP11-338E21.2		10365	0.12
chr11_2290287_2290803	0.12	ASCL2	achaete-scute family bHLH transcription factor 2	1637	0.29
chr17_10018080_10018535	0.12	GAS7	growth arrest-specific 7	437	0.85
chr4_105982764_105983024	0.12	ENSG00000252136	.	44250	0.17
chr3_71626106_71626306	0.12	FOXP1-IT1	FOXP1 intronic transcript 1 (non-protein coding)	2598	0.29
chr6_163826222_163826373	0.12	QKI	QKI, KH domain containing, RNA binding	9378	0.32
chr14_65521176_65521327	0.12	ENSG00000266531	.	9845	0.14
chr8_141124879_141125135	0.12	C8orf17	chromosome 8 open reading frame 17	181591	0.03
chr3_16883275_16883542	0.12	PLCL2	phospholipase C-like 2	43044	0.19
chr2_30371809_30371960	0.12	YPEL5	yippee-like 5 (Drosophila)	1502	0.4
chr20_52198944_52199193	0.12	ZNF217	zinc finger protein 217	568	0.75
chr2_208004362_208004513	0.12	KLF7	Kruppel-like factor 7 (ubiquitous)	5576	0.21
chr4_184580518_184581453	0.12	TRAPPC11	trafficking protein particle complex 11	539	0.46
chr17_27466417_27467105	0.12	MYO18A	myosin XVIIIA	675	0.43
chr1_19642719_19642870	0.11	ENSG00000265192	.	3760	0.13
chr15_64747923_64748074	0.11	ZNF609	zinc finger protein 609	4943	0.14
chr20_43104144_43104478	0.11	TTPAL	tocopherol (alpha) transfer protein-like	215	0.89
chrX_55282426_55282577	0.11	PAGE3	P antigen family, member 3 (prostate associated)	8662	0.21
chr1_33472964_33473115	0.11	RP1-117O3.2		20363	0.13
chr8_126398781_126398932	0.11	RP11-550A5.2		35198	0.17
chr10_45956119_45956270	0.11	RP11-67C2.2		7625	0.26
chr3_46508059_46508210	0.11	LTF	lactotransferrin	1481	0.36
chr5_76361780_76361931	0.11	CTC-564N23.2		7851	0.14
chr7_128580814_128580965	0.11	IRF5	interferon regulatory factor 5	163	0.94
chr2_136871413_136871564	0.11	CXCR4	chemokine (C-X-C motif) receptor 4	2325	0.41

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of DDIT3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0002540	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.2	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.1	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	0.2	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.1	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.1	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0050965	detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0	0.1	GO:0045056	transcytosis(GO:0045056)
0.0	0.1	GO:0032817	regulation of natural killer cell proliferation(GO:0032817)
0.0	0.1	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.1	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0051151	negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0	0.1	GO:0002691	regulation of cellular extravasation(GO:0002691)
0.0	0.1	GO:0036465	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.1	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.1	GO:0018106	peptidyl-histidine phosphorylation(GO:0018106)
0.0	0.1	GO:0052308	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.3	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.1	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.1	GO:1901797	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.1	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.1	GO:0034616	response to laminar fluid shear stress(GO:0034616)
0.0	0.3	GO:0001954	positive regulation of cell-matrix adhesion(GO:0001954)
0.0	0.0	GO:0030309	poly-N-acetyllactosamine metabolic process(GO:0030309)
0.0	0.1	GO:0042520	tyrosine phosphorylation of Stat4 protein(GO:0042504) regulation of tyrosine phosphorylation of Stat4 protein(GO:0042519) positive regulation of tyrosine phosphorylation of Stat4 protein(GO:0042520)
0.0	0.0	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.0	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.3	GO:0060330	regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.0	GO:0042494	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.0	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.1	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.1	GO:0030321	transepithelial chloride transport(GO:0030321)
0.0	0.0	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.0	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0	0.1	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.0	GO:0033591	response to L-ascorbic acid(GO:0033591)
0.0	0.0	GO:0010626	regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626)
0.0	0.1	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.0	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.0	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.0	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.1	GO:0051319	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.0	GO:0036336	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0	0.0	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.0	GO:0007042	lysosomal lumen acidification(GO:0007042) regulation of lysosomal lumen pH(GO:0035751)
0.0	0.0	GO:0002019	regulation of renal output by angiotensin(GO:0002019)
0.0	0.0	GO:0071379	cellular response to prostaglandin stimulus(GO:0071379)
0.0	0.0	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.0	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.3	GO:0000299	obsolete integral to membrane of membrane fraction(GO:0000299)
0.1	GO:0001740	Barr body(GO:0001740)
0.1	GO:0042583	chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.1	GO:0001891	phagocytic cup(GO:0001891)
0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.1	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.5	GO:0000155	phosphorelay sensor kinase activity(GO:0000155)
0.0	0.1	GO:0004875	complement receptor activity(GO:0004875)
0.0	0.1	GO:0004167	dopachrome isomerase activity(GO:0004167)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0001846	opsonin binding(GO:0001846)
0.0	0.1	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.1	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.2	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.1	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.0	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.1	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.1	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.0	0.0	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.3	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.1	GO:0052743	inositol tetrakisphosphate phosphatase activity(GO:0052743)
0.0	0.0	GO:0016972	thiol oxidase activity(GO:0016972)
0.0	0.1	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.1	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.0	0.1	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.1	GO:0051400	BH domain binding(GO:0051400)
0.0	0.0	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.0	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.1	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.0	0.0	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.2	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0	0.6	GO:0004896	cytokine receptor activity(GO:0004896)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.2	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.7	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.2	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.2	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.2	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.2	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation