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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for DLX3_EVX1_MEOX1

Z-value: 0.47

Motif logo

Transcription factors associated with DLX3_EVX1_MEOX1

Gene Symbol	Gene ID	Gene Info
DLX3 Ensembl NCBI GeneCards UniProt	ENSG00000064195.7	DLX3
EVX1 Ensembl NCBI GeneCards UniProt	ENSG00000106038.8	EVX1
MEOX1 Ensembl NCBI GeneCards UniProt	ENSG00000005102.8	MEOX1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
DLX3	chr17_48074174_48074657	1827	0.283554	-0.71	3.3e-02	Click!
DLX3	chr17_48071900_48072168	554	0.711802	-0.68	4.2e-02	Click!
DLX3	chr17_48065551_48065702	5441	0.160340	-0.63	6.8e-02	Click!
DLX3	chr17_48075878_48076029	3365	0.191350	-0.62	7.7e-02	Click!
DLX3	chr17_48072265_48072578	167	0.938338	-0.60	8.9e-02	Click!
EVX1	chr7_27275476_27275737	6558	0.102992	-0.78	1.2e-02	Click!
EVX1	chr7_27282525_27283078	186	0.525290	-0.74	2.2e-02	Click!
EVX1	chr7_27274920_27275071	7169	0.100761	-0.69	3.9e-02	Click!
EVX1	chr7_27275140_27275379	6905	0.101684	-0.63	6.9e-02	Click!
EVX1	chr7_27282158_27282489	4	0.772250	-0.57	1.1e-01	Click!
MEOX1	chr17_41712240_41712391	26616	0.143953	-0.64	6.1e-02	Click!
MEOX1	chr17_41736574_41736725	2282	0.286119	0.59	9.2e-02	Click!
MEOX1	chr17_41738065_41738244	777	0.637485	0.52	1.5e-01	Click!
MEOX1	chr17_41737286_41737476	1550	0.380643	0.50	1.7e-01	Click!
MEOX1	chr17_41737840_41737991	1016	0.530961	0.44	2.4e-01	Click!

Activity of the DLX3_EVX1_MEOX1 motif across conditions

Conditions sorted by the z-value of the DLX3_EVX1_MEOX1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chrX_78400540_78401325	0.53	GPR174	G protein-coupled receptor 174	25537	0.27
chr6_154568354_154568864	0.52	IPCEF1	interaction protein for cytohesin exchange factors 1	53	0.99
chr21_15917916_15918619	0.48	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	395	0.89
chr13_99957828_99957979	0.45	GPR183	G protein-coupled receptor 183	1756	0.38
chr15_75080868_75081404	0.44	ENSG00000264386	.	38	0.76
chr2_158299843_158300108	0.39	CYTIP	cytohesin 1 interacting protein	679	0.68
chr6_24934739_24934890	0.39	FAM65B	family with sequence similarity 65, member B	1374	0.5
chr11_122597673_122598179	0.34	ENSG00000239079	.	907	0.67
chr12_866633_866784	0.31	WNK1	WNK lysine deficient protein kinase 1	3976	0.25
chr20_43599792_43600332	0.31	STK4	serine/threonine kinase 4	4895	0.16
chr2_143887292_143887566	0.30	ARHGAP15	Rho GTPase activating protein 15	546	0.84
chr5_149791368_149791565	0.29	CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	829	0.6
chr1_234544831_234544982	0.29	COA6	cytochrome c oxidase assembly factor 6 homolog (S. cerevisiae)	35459	0.12
chr11_75063727_75063930	0.29	ARRB1	arrestin, beta 1	955	0.48
chr14_22993528_22993679	0.29	TRAJ15	T cell receptor alpha joining 15	4977	0.12
chr13_40532306_40532606	0.27	ENSG00000212553	.	101092	0.08
chr10_6626003_6626633	0.27	PRKCQ	protein kinase C, theta	4055	0.36
chrX_78200973_78201449	0.27	P2RY10	purinergic receptor P2Y, G-protein coupled, 10	293	0.95
chr15_55547653_55548107	0.27	RAB27A	RAB27A, member RAS oncogene family	6647	0.22
chr7_150329820_150329971	0.27	GIMAP6	GTPase, IMAP family member 6	422	0.84
chr2_136876136_136876323	0.26	CXCR4	chemokine (C-X-C motif) receptor 4	494	0.87
chr9_95730621_95730837	0.26	FGD3	FYVE, RhoGEF and PH domain containing 3	4486	0.25
chr17_10601145_10601947	0.26	ADPRM	ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent	635	0.41
chr12_54891959_54892179	0.26	NCKAP1L	NCK-associated protein 1-like	499	0.73
chr4_154411300_154411567	0.26	KIAA0922	KIAA0922	23932	0.22
chrX_147462854_147463013	0.26	AC002368.4		119202	0.06
chr10_73847731_73848399	0.26	SPOCK2	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	21	0.98
chr13_21050204_21050392	0.25	ENSG00000263978	.	42313	0.15
chr8_82022711_82022967	0.25	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	1464	0.56
chr13_77319930_77320170	0.24	KCTD12	potassium channel tetramerization domain containing 12	140475	0.05
chr2_182174133_182174359	0.24	ENSG00000266705	.	3867	0.36
chr14_22955963_22956254	0.23	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	63	0.95
chr19_49139505_49139656	0.23	DBP	D site of albumin promoter (albumin D-box) binding protein	1040	0.28
chr3_152878700_152878913	0.23	RP11-529G21.2		758	0.56
chr6_32158116_32158500	0.23	PBX2	pre-B-cell leukemia homeobox 2	345	0.7
chr2_225809390_225809894	0.22	DOCK10	dedicator of cytokinesis 10	2140	0.45
chr9_95790679_95791025	0.22	FGD3	FYVE, RhoGEF and PH domain containing 3	13510	0.18
chr12_27150397_27150548	0.22	TM7SF3	transmembrane 7 superfamily member 3	2271	0.24
chr12_131796680_131796831	0.22	ENSG00000212251	.	12459	0.23
chr10_129861850_129862130	0.22	PTPRE	protein tyrosine phosphatase, receptor type, E	16156	0.26
chr2_88124610_88124761	0.22	RGPD2	RANBP2-like and GRIP domain containing 2	601	0.82
chr17_75456326_75456913	0.22	SEPT9	septin 9	4171	0.18
chr5_110560941_110561277	0.22	CAMK4	calcium/calmodulin-dependent protein kinase IV	1325	0.51
chrX_40430227_40430433	0.22	ATP6AP2	ATPase, H+ transporting, lysosomal accessory protein 2	9816	0.21
chr10_28622520_28622887	0.22	MPP7	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	712	0.72
chr3_16883621_16883873	0.22	PLCL2	phospholipase C-like 2	42705	0.19
chr6_70525806_70525957	0.22	LMBRD1	LMBR1 domain containing 1	18878	0.25
chr2_161995560_161995711	0.21	TANK	TRAF family member-associated NFKB activator	2169	0.37
chr8_56776921_56777072	0.21	LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	15376	0.15
chr5_126094279_126094440	0.21	ENSG00000252185	.	3250	0.29
chr6_15308796_15308947	0.21	ENSG00000201367	.	6280	0.22
chr3_151921407_151921835	0.21	MBNL1	muscleblind-like splicing regulator 1	64208	0.12
chr2_68993241_68993423	0.21	ARHGAP25	Rho GTPase activating protein 25	8601	0.25
chr5_14560333_14560610	0.21	FAM105A	family with sequence similarity 105, member A	21413	0.23
chr7_37011253_37011404	0.21	ELMO1	engulfment and cell motility 1	13337	0.2
chr4_109056842_109056993	0.20	LEF1	lymphoid enhancer-binding factor 1	30540	0.19
chr10_46075820_46076565	0.20	MARCH8	membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase	13747	0.25
chrX_19815653_19816006	0.20	SH3KBP1	SH3-domain kinase binding protein 1	2040	0.46
chr14_32672268_32672419	0.20	ENSG00000202337	.	132	0.94
chr19_6481304_6482171	0.20	DENND1C	DENN/MADD domain containing 1C	27	0.95
chr1_198627689_198627922	0.20	RP11-553K8.5		8385	0.25
chr5_67577391_67577649	0.20	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	1385	0.58
chr18_56326442_56326593	0.20	MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	12101	0.14
chrX_17754584_17754752	0.20	SCML1	sex comb on midleg-like 1 (Drosophila)	920	0.7
chr1_143741571_143741722	0.20	RP6-206I17.4		21942	0.16
chr16_50623254_50623506	0.20	RP11-401P9.6		24215	0.14
chr14_77838790_77838941	0.20	SAMD15	sterile alpha motif domain containing 15	4167	0.14
chr2_204572133_204572358	0.20	CD28	CD28 molecule	829	0.71
chr18_9404580_9404814	0.20	TWSG1	twisted gastrulation BMP signaling modulator 1	69849	0.08
chr14_22947593_22947744	0.20	TRAJ60	T cell receptor alpha joining 60 (pseudogene)	2372	0.15
chr12_65013240_65013416	0.19	ENSG00000207546	.	2961	0.17
chr1_29254771_29254973	0.19	EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	13781	0.18
chr6_159464766_159465080	0.19	TAGAP	T-cell activation RhoGTPase activating protein	1127	0.51
chr12_94805998_94806149	0.19	CCDC41	coiled-coil domain containing 41	47649	0.14
chr7_115668295_115668446	0.18	TFEC	transcription factor EC	2425	0.43
chr1_47726053_47726204	0.18	STIL	SCL/TAL1 interrupting locus	20601	0.14
chr7_73509063_73509569	0.18	LIMK1	LIM domain kinase 1	1907	0.33
chr1_28975271_28975442	0.18	ENSG00000270103	.	244	0.88
chr6_91004568_91004758	0.18	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2	1798	0.43
chr5_75600050_75600201	0.18	RP11-466P24.6		7162	0.3
chr10_173487_173638	0.18	ZMYND11	zinc finger, MYND-type containing 11	6843	0.24
chr1_236284065_236284436	0.18	GPR137B	G protein-coupled receptor 137B	21582	0.19
chr14_22977314_22977663	0.18	TRAJ15	T cell receptor alpha joining 15	21092	0.09
chr14_22974481_22974956	0.18	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	18547	0.09
chr9_3528863_3529151	0.18	RFX3	regulatory factor X, 3 (influences HLA class II expression)	3003	0.37
chr6_28108040_28108408	0.17	ZKSCAN8	zinc finger with KRAB and SCAN domains 8	1492	0.26
chr3_33478642_33478793	0.17	UBP1	upstream binding protein 1 (LBP-1a)	2785	0.29
chr6_12010262_12011396	0.17	HIVEP1	human immunodeficiency virus type I enhancer binding protein 1	1404	0.51
chr12_92440588_92440837	0.17	C12orf79	chromosome 12 open reading frame 79	90085	0.08
chr7_37480884_37481045	0.17	ENSG00000201566	.	6246	0.2
chr1_186291714_186291865	0.17	ENSG00000202025	.	10729	0.17
chr13_27234189_27234340	0.17	WASF3-AS1	WASF3 antisense RNA 1	18763	0.26
chr12_47600587_47601314	0.17	PCED1B	PC-esterase domain containing 1B	9102	0.22
chr7_6654683_6655004	0.17	ZNF853	zinc finger protein 853	405	0.77
chr3_52235228_52235379	0.17	ALAS1	aminolevulinate, delta-, synthase 1	3143	0.15
chr17_21157480_21157631	0.17	C17orf103	chromosome 17 open reading frame 103	833	0.56
chrX_78196869_78197083	0.17	P2RY10	purinergic receptor P2Y, G-protein coupled, 10	3853	0.37
chr2_193992778_193992929	0.17	TMEFF2	transmembrane protein with EGF-like and two follistatin-like domains 2	932418	0.0
chr7_26141262_26141558	0.17	ENSG00000266430	.	41451	0.15
chrX_118815979_118816490	0.17	SEPT6	septin 6	10558	0.17
chr13_46745397_46745548	0.17	ENSG00000240767	.	1589	0.32
chr6_52151017_52151168	0.16	MCM3	minichromosome maintenance complex component 3	1457	0.45
chr11_128589269_128589524	0.16	SENCR	smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA	23478	0.17
chr1_197884515_197884666	0.16	LHX9	LIM homeobox 9	377	0.89
chr14_64195027_64195308	0.16	SGPP1	sphingosine-1-phosphate phosphatase 1	410	0.84
chr17_29637369_29637894	0.16	EVI2B	ecotropic viral integration site 2B	3471	0.16
chr17_29639732_29640055	0.16	EVI2B	ecotropic viral integration site 2B	1209	0.36
chr1_111420872_111421052	0.16	CD53	CD53 molecule	5186	0.22
chr7_148543528_148543679	0.16	ENSG00000251712	.	25499	0.15
chr14_99703180_99703331	0.16	AL109767.1		26030	0.19
chr7_50348449_50348781	0.16	IKZF1	IKAROS family zinc finger 1 (Ikaros)	297	0.94
chr11_8228040_8228278	0.16	RIC3	RIC3 acetylcholine receptor chaperone	37557	0.16
chr1_150294067_150294674	0.16	PRPF3	pre-mRNA processing factor 3	368	0.78
chr4_37686087_37686238	0.16	RELL1	RELT-like 1	1836	0.39
chr4_144312492_144312643	0.16	GAB1	GRB2-associated binding protein 1	96	0.98
chr13_43564402_43564714	0.16	EPSTI1	epithelial stromal interaction 1 (breast)	809	0.73
chr5_130882612_130883040	0.15	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	14100	0.29
chr7_107530950_107531101	0.15	DLD	dihydrolipoamide dehydrogenase	390	0.88
chr13_97879341_97880219	0.15	MBNL2	muscleblind-like splicing regulator 2	5171	0.33
chr1_192129351_192129646	0.15	RGS18	regulator of G-protein signaling 18	1911	0.5
chr3_30657794_30657945	0.15	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	9776	0.3
chr1_65614810_65615288	0.15	AK4	adenylate kinase 4	1163	0.58
chr5_43017766_43018004	0.15	CTD-2035E11.3		646	0.52
chr5_68338922_68339492	0.15	SLC30A5	solute carrier family 30 (zinc transporter), member 5	50266	0.12
chr3_32280995_32281180	0.15	CMTM8	CKLF-like MARVEL transmembrane domain containing 8	916	0.41
chr5_35781592_35781782	0.15	SPEF2	sperm flagellar 2	2417	0.34
chr2_201983400_201983976	0.15	CFLAR	CASP8 and FADD-like apoptosis regulator	474	0.74
chr4_26887523_26887909	0.15	STIM2	stromal interaction molecule 2	24635	0.21
chr3_135909805_135909956	0.15	MSL2	male-specific lethal 2 homolog (Drosophila)	3516	0.32
chr4_39032495_39032784	0.15	TMEM156	transmembrane protein 156	1402	0.45
chr15_60874237_60874501	0.15	RORA	RAR-related orphan receptor A	10371	0.22
chr1_100820231_100820573	0.15	CDC14A	cell division cycle 14A	1897	0.33
chr3_151911560_151911983	0.15	MBNL1	muscleblind-like splicing regulator 1	74058	0.11
chr9_80524074_80524374	0.15	GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	86309	0.1
chr12_46062870_46063096	0.15	ARID2	AT rich interactive domain 2 (ARID, RFX-like)	60465	0.15
chr11_65324098_65324348	0.15	LTBP3	latent transforming growth factor beta binding protein 3	1013	0.31
chr6_139466066_139466217	0.15	HECA	headcase homolog (Drosophila)	9892	0.26
chr3_98274758_98274909	0.15	GPR15	G protein-coupled receptor 15	24090	0.13
chr6_91123305_91123789	0.15	ENSG00000252676	.	32944	0.21
chr2_113546245_113546396	0.15	IL1A	interleukin 1, alpha	4153	0.2
chr12_12874334_12874808	0.15	RP11-180M15.4		2374	0.2
chr12_11802043_11802302	0.15	ETV6	ets variant 6	616	0.81
chr1_11715091_11715564	0.15	FBXO44	F-box protein 44	360	0.57
chr9_123686452_123686718	0.15	TRAF1	TNF receptor-associated factor 1	4462	0.25
chr11_2322356_2322739	0.14	C11orf21	chromosome 11 open reading frame 21	596	0.44
chr13_46755198_46755455	0.14	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	1133	0.45
chr14_89817609_89817760	0.14	RP11-356K23.1		1038	0.5
chr14_77873229_77873401	0.14	FKSG61		9426	0.11
chr2_171555186_171555337	0.14	AC007277.3		3377	0.22
chr15_44120227_44120469	0.14	WDR76	WD repeat domain 76	1162	0.29
chr1_112018691_112018961	0.14	C1orf162	chromosome 1 open reading frame 162	2335	0.16
chrX_19813800_19813951	0.14	SH3KBP1	SH3-domain kinase binding protein 1	3994	0.35
chr5_79550167_79550318	0.14	SERINC5	serine incorporator 5	1596	0.37
chr3_108541842_108541993	0.14	TRAT1	T cell receptor associated transmembrane adaptor 1	298	0.94
chr10_112632655_112633305	0.14	PDCD4-AS1	PDCD4 antisense RNA 1	989	0.38
chr5_98362961_98363596	0.14	ENSG00000200351	.	90827	0.09
chr4_40201423_40201705	0.14	RHOH	ras homolog family member H	400	0.87
chr7_37488846_37488997	0.14	ELMO1	engulfment and cell motility 1	69	0.98
chr6_26198173_26198564	0.14	HIST1H3D	histone cluster 1, H3d	890	0.22
chr5_171560548_171560699	0.14	ENSG00000266671	.	52643	0.12
chr1_162843054_162843205	0.14	C1orf110	chromosome 1 open reading frame 110	4524	0.29
chr11_75063940_75064091	0.14	ARRB1	arrestin, beta 1	1142	0.41
chr1_231748956_231749347	0.14	LINC00582	long intergenic non-protein coding RNA 582	1315	0.46
chrX_78403286_78403508	0.14	GPR174	G protein-coupled receptor 174	23072	0.28
chr14_70111468_70111619	0.14	KIAA0247	KIAA0247	33230	0.18
chr1_11335043_11335194	0.14	UBIAD1	UbiA prenyltransferase domain containing 1	1127	0.47
chrY_1551045_1551310	0.14	NA	NA	> 10⁶	NA
chr1_100852790_100852941	0.14	ENSG00000216067	.	8534	0.21
chr6_34624121_34624272	0.14	C6orf106	chromosome 6 open reading frame 106	15537	0.14
chr11_14097018_14097169	0.14	ENSG00000212365	.	59439	0.15
chr3_152019403_152019901	0.14	MBNL1	muscleblind-like splicing regulator 1	1665	0.42
chrX_19823659_19823810	0.14	SH3KBP1	SH3-domain kinase binding protein 1	5865	0.31
chr5_118606885_118607036	0.14	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	2511	0.28
chrX_1600809_1601304	0.13	ASMTL	acetylserotonin O-methyltransferase-like	28401	0.16
chr5_35861092_35861243	0.13	IL7R	interleukin 7 receptor	4173	0.24
chr3_187676320_187676496	0.13	LPP	LIM domain containing preferred translocation partner in lipoma	194664	0.03
chr21_34760648_34760799	0.13	IFNGR2	interferon gamma receptor 2 (interferon gamma transducer 1)	14479	0.17
chr11_67037576_67038089	0.13	ADRBK1	adrenergic, beta, receptor kinase 1	3880	0.14
chr12_1399393_1399544	0.13	RP5-951N9.2		95531	0.08
chr1_111215065_111215351	0.13	KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	2447	0.28
chr17_44849363_44850053	0.13	NSF	N-ethylmaleimide-sensitive factor	45786	0.13
chr1_39500021_39500217	0.13	NDUFS5	NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)	8129	0.18
chr11_57794441_57794592	0.13	ENSG00000200817	.	232	0.91
chr3_119182906_119183082	0.13	TMEM39A	transmembrane protein 39A	465	0.79
chr1_29253817_29254129	0.13	EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	12882	0.18
chr3_101568772_101569567	0.13	NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	62	0.98
chr10_63813819_63813970	0.13	ARID5B	AT rich interactive domain 5B (MRF1-like)	4924	0.3
chr13_75898854_75899075	0.13	TBC1D4	TBC1 domain family, member 4	16703	0.24
chr3_151963607_151963763	0.13	MBNL1	muscleblind-like splicing regulator 1	22144	0.21
chr3_69129681_69129838	0.13	UBA3	ubiquitin-like modifier activating enzyme 3	200	0.92
chr21_36398548_36398777	0.13	RUNX1	runt-related transcription factor 1	22800	0.28
chr5_75826683_75826834	0.13	IQGAP2	IQ motif containing GTPase activating protein 2	16476	0.24
chr5_148931227_148931707	0.13	ARHGEF37	Rho guanine nucleotide exchange factor (GEF) 37	43	0.88
chr7_155326313_155326555	0.13	CNPY1	canopy FGF signaling regulator 1	99	0.97
chr3_45732221_45732372	0.13	SACM1L	SAC1 suppressor of actin mutations 1-like (yeast)	1345	0.36
chr9_20242645_20242902	0.13	ENSG00000221744	.	52229	0.16
chr4_39045572_39046195	0.13	KLHL5	kelch-like family member 5	776	0.67
chr14_91863541_91863979	0.13	CCDC88C	coiled-coil domain containing 88C	19930	0.21
chr2_98698576_98698727	0.13	VWA3B	von Willebrand factor A domain containing 3B	4944	0.3
chr10_91461400_91461679	0.13	KIF20B	kinesin family member 20B	103	0.98

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of DLX3_EVX1_MEOX1

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0010040	response to iron(II) ion(GO:0010040)
0.1	0.2	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1	0.6	GO:0015671	oxygen transport(GO:0015671)
0.1	0.2	GO:0030011	maintenance of cell polarity(GO:0030011)
0.1	0.3	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.1	0.3	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	0.2	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.1	0.2	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.1	0.2	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.0	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0	0.1	GO:0002540	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.2	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.1	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.2	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.2	GO:0044380	protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0	0.2	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.3	GO:0006670	sphingosine metabolic process(GO:0006670)
0.0	0.1	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.1	GO:0036336	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0	0.1	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.1	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.1	GO:0045586	regulation of gamma-delta T cell differentiation(GO:0045586) positive regulation of gamma-delta T cell differentiation(GO:0045588)
0.0	0.1	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.3	GO:0019059	obsolete initiation of viral infection(GO:0019059)
0.0	0.1	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.2	GO:0045116	protein neddylation(GO:0045116)
0.0	0.1	GO:1904019	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0	0.2	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.1	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.0	0.1	GO:0003351	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.1	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.0	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.0	0.1	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.1	GO:0032695	negative regulation of interleukin-12 production(GO:0032695)
0.0	0.1	GO:0030210	heparin biosynthetic process(GO:0030210)
0.0	0.0	GO:0002335	mature B cell differentiation(GO:0002335)
0.0	0.2	GO:0042362	fat-soluble vitamin biosynthetic process(GO:0042362)
0.0	0.1	GO:0006658	phosphatidylserine metabolic process(GO:0006658)
0.0	0.1	GO:0048670	regulation of collateral sprouting(GO:0048670)
0.0	0.1	GO:0000380	alternative mRNA splicing, via spliceosome(GO:0000380)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.1	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.1	GO:0032237	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.1	GO:0072216	positive regulation of metanephros development(GO:0072216)
0.0	0.1	GO:0021683	cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.2	GO:0006379	mRNA cleavage(GO:0006379)
0.0	0.0	GO:0003161	cardiac conduction system development(GO:0003161)
0.0	0.1	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.1	GO:0002507	tolerance induction(GO:0002507)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.2	GO:0010324	phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0	0.1	GO:0006011	UDP-glucose metabolic process(GO:0006011)
0.0	0.4	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.1	GO:0043137	DNA replication, Okazaki fragment processing(GO:0033567) DNA replication, removal of RNA primer(GO:0043137)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.1	GO:0002423	natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0	0.1	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
0.0	0.1	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.0	GO:0032621	interleukin-18 production(GO:0032621) regulation of interleukin-18 production(GO:0032661)
0.0	0.0	GO:0071360	cellular response to exogenous dsRNA(GO:0071360)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.0	GO:1901984	negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0	0.1	GO:0033160	positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0	0.1	GO:0008535	respiratory chain complex IV assembly(GO:0008535)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.0	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.1	GO:0046856	phosphatidylinositol dephosphorylation(GO:0046856)
0.0	0.0	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.1	GO:0006554	lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0	0.0	GO:0030186	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.0	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.0	GO:0045349	interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.0	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0	0.1	GO:0045746	negative regulation of Notch signaling pathway(GO:0045746)
0.0	0.0	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.0	GO:0060972	left/right pattern formation(GO:0060972)
0.0	0.0	GO:0001821	histamine secretion(GO:0001821)
0.0	0.1	GO:0051319	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.3	GO:0046677	response to antibiotic(GO:0046677)
0.0	0.0	GO:0002693	positive regulation of cellular extravasation(GO:0002693)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.0	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.0	GO:0006538	glutamate catabolic process(GO:0006538)
0.0	0.8	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.0	GO:0060049	regulation of protein glycosylation(GO:0060049)
0.0	0.0	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.0	GO:0015801	aromatic amino acid transport(GO:0015801)
0.0	0.0	GO:0034616	response to laminar fluid shear stress(GO:0034616)
0.0	0.0	GO:2000400	positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0	0.0	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0	0.1	GO:0002483	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.1	GO:0016584	nucleosome positioning(GO:0016584)
0.0	0.0	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0	0.2	GO:0016254	preassembly of GPI anchor in ER membrane(GO:0016254)
0.0	0.0	GO:0045040	outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.1	GO:0090205	positive regulation of cholesterol metabolic process(GO:0090205)
0.0	0.0	GO:0045359	interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.0	0.0	GO:0060539	diaphragm development(GO:0060539)
0.0	0.0	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.0	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.1	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.0	0.1	GO:0045601	regulation of endothelial cell differentiation(GO:0045601)
0.0	0.0	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.1	GO:0006547	histidine metabolic process(GO:0006547)
0.0	0.0	GO:2000380	regulation of mesodermal cell fate specification(GO:0042661) regulation of mesoderm development(GO:2000380)
0.0	0.0	GO:0002093	auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.0	0.0	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.1	GO:0010745	negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.0	0.0	GO:0070102	interleukin-6-mediated signaling pathway(GO:0070102)
0.0	0.1	GO:0070536	protein K63-linked deubiquitination(GO:0070536)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0072487	MSL complex(GO:0072487)
0.1	0.2	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.0	0.2	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.4	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.2	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.2	GO:0031143	pseudopodium(GO:0031143)
0.0	0.2	GO:0034451	centriolar satellite(GO:0034451)
0.0	0.1	GO:0017059	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.1	GO:0042629	mast cell granule(GO:0042629)
0.0	0.3	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.0	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.2	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.2	GO:0005849	mRNA cleavage factor complex(GO:0005849)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0034464	BBSome(GO:0034464)
0.0	0.1	GO:0098799	outer mitochondrial membrane protein complex(GO:0098799)
0.0	0.1	GO:0045239	tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0	0.1	GO:0016580	Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822)
0.0	0.2	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.0	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.0	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.0	GO:0070062	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.0	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.1	GO:0005869	dynactin complex(GO:0005869)
0.0	0.0	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.0	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.4	GO:0030175	filopodium(GO:0030175)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.1	GO:0030130	clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0	0.0	GO:0032009	early phagosome(GO:0032009)
0.0	0.0	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.0	0.1	GO:0030992	intraciliary transport particle B(GO:0030992)
0.0	0.1	GO:0001772	immunological synapse(GO:0001772)
0.0	0.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.1	GO:0000791	euchromatin(GO:0000791)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1	0.5	GO:0001784	phosphotyrosine binding(GO:0001784)
0.1	0.2	GO:0042289	MHC class II protein binding(GO:0042289)
0.1	0.2	GO:0050544	arachidonic acid binding(GO:0050544)
0.1	0.3	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.3	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	1.1	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.6	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.2	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.1	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.1	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.2	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.1	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.1	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.2	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.2	GO:0008641	small protein activating enzyme activity(GO:0008641)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.0	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.1	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.7	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.0	GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.1	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0017108	5'-flap endonuclease activity(GO:0017108)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0004437	obsolete inositol or phosphatidylinositol phosphatase activity(GO:0004437)
0.0	0.0	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.2	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.1	GO:0015385	sodium:proton antiporter activity(GO:0015385)
0.0	0.1	GO:0034235	GPI anchor binding(GO:0034235)
0.0	0.0	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.0	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.0	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.1	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.0	0.0	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.0	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.1	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.1	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.0	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.0	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0016778	diphosphotransferase activity(GO:0016778)
0.0	0.0	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.0	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0	0.0	GO:0015194	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.0	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	0.1	GO:0061659	ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0	0.0	GO:0004307	ethanolaminephosphotransferase activity(GO:0004307)
0.0	0.0	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.1	GO:0008139	nuclear localization sequence binding(GO:0008139)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	PID IL5 PATHWAY	IL5-mediated signaling events
0.6	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.2	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.6	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
1.0	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.2	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.4	PID S1P S1P3 PATHWAY	S1P3 pathway
0.3	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.3	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.2	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.2	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.6	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1	PID IL3 PATHWAY	IL3-mediated signaling events
0.0	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.6	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.1	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.1	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.2	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.5	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.5	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.4	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.1	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.0	0.2	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.3	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.3	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.4	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.0	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	0.0	REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION	Genes involved in 3' -UTR-mediated translational regulation
0.0	0.4	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	0.3	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.2	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs
0.0	0.3	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.2	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.0	REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0	0.0	REACTOME SIGNAL AMPLIFICATION	Genes involved in Signal amplification
0.0	0.7	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.0	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.3	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.0	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	0.2	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.0	0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.1	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.1	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.0	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.1	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	0.0	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0	0.0	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.1	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.2	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)