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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for DLX3_EVX1_MEOX1

Z-value: 0.47

Motif logo

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Transcription factors associated with DLX3_EVX1_MEOX1

Gene Symbol Gene ID Gene Info
DLX3
ENSG00000064195.7 distal-less homeobox 3
EVX1
ENSG00000106038.8 even-skipped homeobox 1
MEOX1
ENSG00000005102.8 mesenchyme homeobox 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr17_48074174_48074657DLX318270.283554-0.713.3e-02Click!
chr17_48071900_48072168DLX35540.711802-0.684.2e-02Click!
chr17_48065551_48065702DLX354410.160340-0.636.8e-02Click!
chr17_48075878_48076029DLX333650.191350-0.627.7e-02Click!
chr17_48072265_48072578DLX31670.938338-0.608.9e-02Click!
chr7_27275476_27275737EVX165580.102992-0.781.2e-02Click!
chr7_27282525_27283078EVX11860.525290-0.742.2e-02Click!
chr7_27274920_27275071EVX171690.100761-0.693.9e-02Click!
chr7_27275140_27275379EVX169050.101684-0.636.9e-02Click!
chr7_27282158_27282489EVX140.772250-0.571.1e-01Click!
chr17_41712240_41712391MEOX1266160.143953-0.646.1e-02Click!
chr17_41736574_41736725MEOX122820.2861190.599.2e-02Click!
chr17_41738065_41738244MEOX17770.6374850.521.5e-01Click!
chr17_41737286_41737476MEOX115500.3806430.501.7e-01Click!
chr17_41737840_41737991MEOX110160.5309610.442.4e-01Click!

Activity of the DLX3_EVX1_MEOX1 motif across conditions

Conditions sorted by the z-value of the DLX3_EVX1_MEOX1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chrX_78400540_78401325 0.53 GPR174
 G protein-coupled receptor 174
 25537
 0.27
chr6_154568354_154568864 0.52 IPCEF1
 interaction protein for cytohesin exchange factors 1
 53
 0.99
chr21_15917916_15918619 0.48 SAMSN1
 SAM domain, SH3 domain and nuclear localization signals 1
 395
 0.89
chr13_99957828_99957979 0.45 GPR183
 G protein-coupled receptor 183
 1756
 0.38
chr15_75080868_75081404 0.44 ENSG00000264386
 .
 38
 0.76
chr2_158299843_158300108 0.39 CYTIP
 cytohesin 1 interacting protein
 679
 0.68
chr6_24934739_24934890 0.39 FAM65B
 family with sequence similarity 65, member B
 1374
 0.5
chr11_122597673_122598179 0.34 ENSG00000239079
 .
 907
 0.67
chr12_866633_866784 0.31 WNK1
 WNK lysine deficient protein kinase 1
 3976
 0.25
chr20_43599792_43600332 0.31 STK4
 serine/threonine kinase 4
 4895
 0.16
chr2_143887292_143887566 0.30 ARHGAP15
 Rho GTPase activating protein 15
 546
 0.84
chr5_149791368_149791565 0.29 CD74
 CD74 molecule, major histocompatibility complex, class II invariant chain
 829
 0.6
chr1_234544831_234544982 0.29 COA6
 cytochrome c oxidase assembly factor 6 homolog (S. cerevisiae)
 35459
 0.12
chr11_75063727_75063930 0.29 ARRB1
 arrestin, beta 1
 955
 0.48
chr14_22993528_22993679 0.29 TRAJ15
 T cell receptor alpha joining 15
 4977
 0.12
chr13_40532306_40532606 0.27 ENSG00000212553
 .
 101092
 0.08
chr10_6626003_6626633 0.27 PRKCQ
 protein kinase C, theta
 4055
 0.36
chrX_78200973_78201449 0.27 P2RY10
 purinergic receptor P2Y, G-protein coupled, 10
 293
 0.95
chr15_55547653_55548107 0.27 RAB27A
 RAB27A, member RAS oncogene family
 6647
 0.22
chr7_150329820_150329971 0.27 GIMAP6
 GTPase, IMAP family member 6
 422
 0.84
chr2_136876136_136876323 0.26 CXCR4
 chemokine (C-X-C motif) receptor 4
 494
 0.87
chr9_95730621_95730837 0.26 FGD3
 FYVE, RhoGEF and PH domain containing 3
 4486
 0.25
chr17_10601145_10601947 0.26 ADPRM
 ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
 635
 0.41
chr12_54891959_54892179 0.26 NCKAP1L
 NCK-associated protein 1-like
 499
 0.73
chr4_154411300_154411567 0.26 KIAA0922
 KIAA0922
 23932
 0.22
chrX_147462854_147463013 0.26 AC002368.4
119202
 0.06
chr10_73847731_73848399 0.26 SPOCK2
 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
 21
 0.98
chr13_21050204_21050392 0.25 ENSG00000263978
 .
 42313
 0.15
chr8_82022711_82022967 0.25 PAG1
 phosphoprotein associated with glycosphingolipid microdomains 1
 1464
 0.56
chr13_77319930_77320170 0.24 KCTD12
 potassium channel tetramerization domain containing 12
 140475
 0.05
chr2_182174133_182174359 0.24 ENSG00000266705
 .
 3867
 0.36
chr14_22955963_22956254 0.23 TRAJ51
 T cell receptor alpha joining 51 (pseudogene)
 63
 0.95
chr19_49139505_49139656 0.23 DBP
 D site of albumin promoter (albumin D-box) binding protein
 1040
 0.28
chr3_152878700_152878913 0.23 RP11-529G21.2
758
 0.56
chr6_32158116_32158500 0.23 PBX2
 pre-B-cell leukemia homeobox 2
 345
 0.7
chr2_225809390_225809894 0.22 DOCK10
 dedicator of cytokinesis 10
 2140
 0.45
chr9_95790679_95791025 0.22 FGD3
 FYVE, RhoGEF and PH domain containing 3
 13510
 0.18
chr12_27150397_27150548 0.22 TM7SF3
 transmembrane 7 superfamily member 3
 2271
 0.24
chr12_131796680_131796831 0.22 ENSG00000212251
 .
 12459
 0.23
chr10_129861850_129862130 0.22 PTPRE
 protein tyrosine phosphatase, receptor type, E
 16156
 0.26
chr2_88124610_88124761 0.22 RGPD2
 RANBP2-like and GRIP domain containing 2
 601
 0.82
chr17_75456326_75456913 0.22 SEPT9
 septin 9
 4171
 0.18
chr5_110560941_110561277 0.22 CAMK4
 calcium/calmodulin-dependent protein kinase IV
 1325
 0.51
chrX_40430227_40430433 0.22 ATP6AP2
 ATPase, H+ transporting, lysosomal accessory protein 2
 9816
 0.21
chr10_28622520_28622887 0.22 MPP7
 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
 712
 0.72
chr3_16883621_16883873 0.22 PLCL2
 phospholipase C-like 2
 42705
 0.19
chr6_70525806_70525957 0.22 LMBRD1
 LMBR1 domain containing 1
 18878
 0.25
chr2_161995560_161995711 0.21 TANK
 TRAF family member-associated NFKB activator
 2169
 0.37
chr8_56776921_56777072 0.21 LYN
 v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
 15376
 0.15
chr5_126094279_126094440 0.21 ENSG00000252185
 .
 3250
 0.29
chr6_15308796_15308947 0.21 ENSG00000201367
 .
 6280
 0.22
chr3_151921407_151921835 0.21 MBNL1
 muscleblind-like splicing regulator 1
 64208
 0.12
chr2_68993241_68993423 0.21 ARHGAP25
 Rho GTPase activating protein 25
 8601
 0.25
chr5_14560333_14560610 0.21 FAM105A
 family with sequence similarity 105, member A
 21413
 0.23
chr7_37011253_37011404 0.21 ELMO1
 engulfment and cell motility 1
 13337
 0.2
chr4_109056842_109056993 0.20 LEF1
 lymphoid enhancer-binding factor 1
 30540
 0.19
chr10_46075820_46076565 0.20 MARCH8
 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
 13747
 0.25
chrX_19815653_19816006 0.20 SH3KBP1
 SH3-domain kinase binding protein 1
 2040
 0.46
chr14_32672268_32672419 0.20 ENSG00000202337
 .
 132
 0.94
chr19_6481304_6482171 0.20 DENND1C
 DENN/MADD domain containing 1C
 27
 0.95
chr1_198627689_198627922 0.20 RP11-553K8.5
8385
 0.25
chr5_67577391_67577649 0.20 PIK3R1
 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
 1385
 0.58
chr18_56326442_56326593 0.20 MALT1
 mucosa associated lymphoid tissue lymphoma translocation gene 1
 12101
 0.14
chrX_17754584_17754752 0.20 SCML1
 sex comb on midleg-like 1 (Drosophila)
 920
 0.7
chr1_143741571_143741722 0.20 RP6-206I17.4
21942
 0.16
chr16_50623254_50623506 0.20 RP11-401P9.6
24215
 0.14
chr14_77838790_77838941 0.20 SAMD15
 sterile alpha motif domain containing 15
 4167
 0.14
chr2_204572133_204572358 0.20 CD28
 CD28 molecule
 829
 0.71
chr18_9404580_9404814 0.20 TWSG1
 twisted gastrulation BMP signaling modulator 1
 69849
 0.08
chr14_22947593_22947744 0.20 TRAJ60
 T cell receptor alpha joining 60 (pseudogene)
 2372
 0.15
chr12_65013240_65013416 0.19 ENSG00000207546
 .
 2961
 0.17
chr1_29254771_29254973 0.19 EPB41
 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
 13781
 0.18
chr6_159464766_159465080 0.19 TAGAP
 T-cell activation RhoGTPase activating protein
 1127
 0.51
chr12_94805998_94806149 0.19 CCDC41
 coiled-coil domain containing 41
 47649
 0.14
chr7_115668295_115668446 0.18 TFEC
 transcription factor EC
 2425
 0.43
chr1_47726053_47726204 0.18 STIL
 SCL/TAL1 interrupting locus
 20601
 0.14
chr7_73509063_73509569 0.18 LIMK1
 LIM domain kinase 1
 1907
 0.33
chr1_28975271_28975442 0.18 ENSG00000270103
 .
 244
 0.88
chr6_91004568_91004758 0.18 BACH2
 BTB and CNC homology 1, basic leucine zipper transcription factor 2
 1798
 0.43
chr5_75600050_75600201 0.18 RP11-466P24.6
7162
 0.3
chr10_173487_173638 0.18 ZMYND11
 zinc finger, MYND-type containing 11
 6843
 0.24
chr1_236284065_236284436 0.18 GPR137B
 G protein-coupled receptor 137B
 21582
 0.19
chr14_22977314_22977663 0.18 TRAJ15
 T cell receptor alpha joining 15
 21092
 0.09
chr14_22974481_22974956 0.18 TRAJ51
 T cell receptor alpha joining 51 (pseudogene)
 18547
 0.09
chr9_3528863_3529151 0.18 RFX3
 regulatory factor X, 3 (influences HLA class II expression)
 3003
 0.37
chr6_28108040_28108408 0.17 ZKSCAN8
 zinc finger with KRAB and SCAN domains 8
 1492
 0.26
chr3_33478642_33478793 0.17 UBP1
 upstream binding protein 1 (LBP-1a)
 2785
 0.29
chr6_12010262_12011396 0.17 HIVEP1
 human immunodeficiency virus type I enhancer binding protein 1
 1404
 0.51
chr12_92440588_92440837 0.17 C12orf79
 chromosome 12 open reading frame 79
 90085
 0.08
chr7_37480884_37481045 0.17 ENSG00000201566
 .
 6246
 0.2
chr1_186291714_186291865 0.17 ENSG00000202025
 .
 10729
 0.17
chr13_27234189_27234340 0.17 WASF3-AS1
 WASF3 antisense RNA 1
 18763
 0.26
chr12_47600587_47601314 0.17 PCED1B
 PC-esterase domain containing 1B
 9102
 0.22
chr7_6654683_6655004 0.17 ZNF853
 zinc finger protein 853
 405
 0.77
chr3_52235228_52235379 0.17 ALAS1
 aminolevulinate, delta-, synthase 1
 3143
 0.15
chr17_21157480_21157631 0.17 C17orf103
 chromosome 17 open reading frame 103
 833
 0.56
chrX_78196869_78197083 0.17 P2RY10
 purinergic receptor P2Y, G-protein coupled, 10
 3853
 0.37
chr2_193992778_193992929 0.17 TMEFF2
 transmembrane protein with EGF-like and two follistatin-like domains 2
 932418
 0.0
chr7_26141262_26141558 0.17 ENSG00000266430
 .
 41451
 0.15
chrX_118815979_118816490 0.17 SEPT6
 septin 6
 10558
 0.17
chr13_46745397_46745548 0.17 ENSG00000240767
 .
 1589
 0.32
chr6_52151017_52151168 0.16 MCM3
 minichromosome maintenance complex component 3
 1457
 0.45
chr11_128589269_128589524 0.16 SENCR
 smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA
 23478
 0.17
chr1_197884515_197884666 0.16 LHX9
 LIM homeobox 9
 377
 0.89
chr14_64195027_64195308 0.16 SGPP1
 sphingosine-1-phosphate phosphatase 1
 410
 0.84
chr17_29637369_29637894 0.16 EVI2B
 ecotropic viral integration site 2B
 3471
 0.16
chr17_29639732_29640055 0.16 EVI2B
 ecotropic viral integration site 2B
 1209
 0.36
chr1_111420872_111421052 0.16 CD53
 CD53 molecule
 5186
 0.22
chr7_148543528_148543679 0.16 ENSG00000251712
 .
 25499
 0.15
chr14_99703180_99703331 0.16 AL109767.1
26030
 0.19
chr7_50348449_50348781 0.16 IKZF1
 IKAROS family zinc finger 1 (Ikaros)
 297
 0.94
chr11_8228040_8228278 0.16 RIC3
 RIC3 acetylcholine receptor chaperone
 37557
 0.16
chr1_150294067_150294674 0.16 PRPF3
 pre-mRNA processing factor 3
 368
 0.78
chr4_37686087_37686238 0.16 RELL1
 RELT-like 1
 1836
 0.39
chr4_144312492_144312643 0.16 GAB1
 GRB2-associated binding protein 1
 96
 0.98
chr13_43564402_43564714 0.16 EPSTI1
 epithelial stromal interaction 1 (breast)
 809
 0.73
chr5_130882612_130883040 0.15 RAPGEF6
 Rap guanine nucleotide exchange factor (GEF) 6
 14100
 0.29
chr7_107530950_107531101 0.15 DLD
 dihydrolipoamide dehydrogenase
 390
 0.88
chr13_97879341_97880219 0.15 MBNL2
 muscleblind-like splicing regulator 2
 5171
 0.33
chr1_192129351_192129646 0.15 RGS18
 regulator of G-protein signaling 18
 1911
 0.5
chr3_30657794_30657945 0.15 TGFBR2
 transforming growth factor, beta receptor II (70/80kDa)
 9776
 0.3
chr1_65614810_65615288 0.15 AK4
 adenylate kinase 4
 1163
 0.58
chr5_43017766_43018004 0.15 CTD-2035E11.3
646
 0.52
chr5_68338922_68339492 0.15 SLC30A5
 solute carrier family 30 (zinc transporter), member 5
 50266
 0.12
chr3_32280995_32281180 0.15 CMTM8
 CKLF-like MARVEL transmembrane domain containing 8
 916
 0.41
chr5_35781592_35781782 0.15 SPEF2
 sperm flagellar 2
 2417
 0.34
chr2_201983400_201983976 0.15 CFLAR
 CASP8 and FADD-like apoptosis regulator
 474
 0.74
chr4_26887523_26887909 0.15 STIM2
 stromal interaction molecule 2
 24635
 0.21
chr3_135909805_135909956 0.15 MSL2
 male-specific lethal 2 homolog (Drosophila)
 3516
 0.32
chr4_39032495_39032784 0.15 TMEM156
 transmembrane protein 156
 1402
 0.45
chr15_60874237_60874501 0.15 RORA
 RAR-related orphan receptor A
 10371
 0.22
chr1_100820231_100820573 0.15 CDC14A
 cell division cycle 14A
 1897
 0.33
chr3_151911560_151911983 0.15 MBNL1
 muscleblind-like splicing regulator 1
 74058
 0.11
chr9_80524074_80524374 0.15 GNAQ
 guanine nucleotide binding protein (G protein), q polypeptide
 86309
 0.1
chr12_46062870_46063096 0.15 ARID2
 AT rich interactive domain 2 (ARID, RFX-like)
 60465
 0.15
chr11_65324098_65324348 0.15 LTBP3
 latent transforming growth factor beta binding protein 3
 1013
 0.31
chr6_139466066_139466217 0.15 HECA
 headcase homolog (Drosophila)
 9892
 0.26
chr3_98274758_98274909 0.15 GPR15
 G protein-coupled receptor 15
 24090
 0.13
chr6_91123305_91123789 0.15 ENSG00000252676
 .
 32944
 0.21
chr2_113546245_113546396 0.15 IL1A
 interleukin 1, alpha
 4153
 0.2
chr12_12874334_12874808 0.15 RP11-180M15.4
2374
 0.2
chr12_11802043_11802302 0.15 ETV6
 ets variant 6
 616
 0.81
chr1_11715091_11715564 0.15 FBXO44
 F-box protein 44
 360
 0.57
chr9_123686452_123686718 0.15 TRAF1
 TNF receptor-associated factor 1
 4462
 0.25
chr11_2322356_2322739 0.14 C11orf21
 chromosome 11 open reading frame 21
 596
 0.44
chr13_46755198_46755455 0.14 LCP1
 lymphocyte cytosolic protein 1 (L-plastin)
 1133
 0.45
chr14_89817609_89817760 0.14 RP11-356K23.1
1038
 0.5
chr14_77873229_77873401 0.14 FKSG61
9426
 0.11
chr2_171555186_171555337 0.14 AC007277.3
3377
 0.22
chr15_44120227_44120469 0.14 WDR76
 WD repeat domain 76
 1162
 0.29
chr1_112018691_112018961 0.14 C1orf162
 chromosome 1 open reading frame 162
 2335
 0.16
chrX_19813800_19813951 0.14 SH3KBP1
 SH3-domain kinase binding protein 1
 3994
 0.35
chr5_79550167_79550318 0.14 SERINC5
 serine incorporator 5
 1596
 0.37
chr3_108541842_108541993 0.14 TRAT1
 T cell receptor associated transmembrane adaptor 1
 298
 0.94
chr10_112632655_112633305 0.14 PDCD4-AS1
 PDCD4 antisense RNA 1
 989
 0.38
chr5_98362961_98363596 0.14 ENSG00000200351
 .
 90827
 0.09
chr4_40201423_40201705 0.14 RHOH
 ras homolog family member H
 400
 0.87
chr7_37488846_37488997 0.14 ELMO1
 engulfment and cell motility 1
 69
 0.98
chr6_26198173_26198564 0.14 HIST1H3D
 histone cluster 1, H3d
 890
 0.22
chr5_171560548_171560699 0.14 ENSG00000266671
 .
 52643
 0.12
chr1_162843054_162843205 0.14 C1orf110
 chromosome 1 open reading frame 110
 4524
 0.29
chr11_75063940_75064091 0.14 ARRB1
 arrestin, beta 1
 1142
 0.41
chr1_231748956_231749347 0.14 LINC00582
 long intergenic non-protein coding RNA 582
 1315
 0.46
chrX_78403286_78403508 0.14 GPR174
 G protein-coupled receptor 174
 23072
 0.28
chr14_70111468_70111619 0.14 KIAA0247
 KIAA0247
 33230
 0.18
chr1_11335043_11335194 0.14 UBIAD1
 UbiA prenyltransferase domain containing 1
 1127
 0.47
chrY_1551045_1551310 0.14 NA
 NA
 > 106
 NA
chr1_100852790_100852941 0.14 ENSG00000216067
 .
 8534
 0.21
chr6_34624121_34624272 0.14 C6orf106
 chromosome 6 open reading frame 106
 15537
 0.14
chr11_14097018_14097169 0.14 ENSG00000212365
 .
 59439
 0.15
chr3_152019403_152019901 0.14 MBNL1
 muscleblind-like splicing regulator 1
 1665
 0.42
chrX_19823659_19823810 0.14 SH3KBP1
 SH3-domain kinase binding protein 1
 5865
 0.31
chr5_118606885_118607036 0.14 TNFAIP8
 tumor necrosis factor, alpha-induced protein 8
 2511
 0.28
chrX_1600809_1601304 0.13 ASMTL
 acetylserotonin O-methyltransferase-like
 28401
 0.16
chr5_35861092_35861243 0.13 IL7R
 interleukin 7 receptor
 4173
 0.24
chr3_187676320_187676496 0.13 LPP
 LIM domain containing preferred translocation partner in lipoma
 194664
 0.03
chr21_34760648_34760799 0.13 IFNGR2
 interferon gamma receptor 2 (interferon gamma transducer 1)
 14479
 0.17
chr11_67037576_67038089 0.13 ADRBK1
 adrenergic, beta, receptor kinase 1
 3880
 0.14
chr12_1399393_1399544 0.13 RP5-951N9.2
95531
 0.08
chr1_111215065_111215351 0.13 KCNA3
 potassium voltage-gated channel, shaker-related subfamily, member 3
 2447
 0.28
chr17_44849363_44850053 0.13 NSF
 N-ethylmaleimide-sensitive factor
 45786
 0.13
chr1_39500021_39500217 0.13 NDUFS5
 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)
 8129
 0.18
chr11_57794441_57794592 0.13 ENSG00000200817
 .
 232
 0.91
chr3_119182906_119183082 0.13 TMEM39A
 transmembrane protein 39A
 465
 0.79
chr1_29253817_29254129 0.13 EPB41
 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
 12882
 0.18
chr3_101568772_101569567 0.13 NFKBIZ
 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
 62
 0.98
chr10_63813819_63813970 0.13 ARID5B
 AT rich interactive domain 5B (MRF1-like)
 4924
 0.3
chr13_75898854_75899075 0.13 TBC1D4
 TBC1 domain family, member 4
 16703
 0.24
chr3_151963607_151963763 0.13 MBNL1
 muscleblind-like splicing regulator 1
 22144
 0.21
chr3_69129681_69129838 0.13 UBA3
 ubiquitin-like modifier activating enzyme 3
 200
 0.92
chr21_36398548_36398777 0.13 RUNX1
 runt-related transcription factor 1
 22800
 0.28
chr5_75826683_75826834 0.13 IQGAP2
 IQ motif containing GTPase activating protein 2
 16476
 0.24
chr5_148931227_148931707 0.13 ARHGEF37
 Rho guanine nucleotide exchange factor (GEF) 37
 43
 0.88
chr7_155326313_155326555 0.13 CNPY1
 canopy FGF signaling regulator 1
 99
 0.97
chr3_45732221_45732372 0.13 SACM1L
 SAC1 suppressor of actin mutations 1-like (yeast)
 1345
 0.36
chr9_20242645_20242902 0.13 ENSG00000221744
 .
 52229
 0.16
chr4_39045572_39046195 0.13 KLHL5
 kelch-like family member 5
 776
 0.67
chr14_91863541_91863979 0.13 CCDC88C
 coiled-coil domain containing 88C
 19930
 0.21
chr2_98698576_98698727 0.13 VWA3B
 von Willebrand factor A domain containing 3B
 4944
 0.3
chr10_91461400_91461679 0.13 KIF20B
 kinesin family member 20B
 103
 0.98

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of DLX3_EVX1_MEOX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0010040 response to iron(II) ion(GO:0010040)
0.1 0.2 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1 0.6 GO:0015671 oxygen transport(GO:0015671)
0.1 0.2 GO:0030011 maintenance of cell polarity(GO:0030011)
0.1 0.3 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.1 0.3 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1 0.2 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.1 0.2 GO:0002323 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.1 0.2 GO:0009106 lipoate metabolic process(GO:0009106)
0.0 0.0 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 0.1 GO:0002540 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0 0.2 GO:0045066 regulatory T cell differentiation(GO:0045066)
0.0 0.1 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.2 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.2 GO:0044380 protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0 0.2 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.3 GO:0006670 sphingosine metabolic process(GO:0006670)
0.0 0.1 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.1 GO:0036336 dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0 0.1 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.0 0.1 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0 0.1 GO:0045586 regulation of gamma-delta T cell differentiation(GO:0045586) positive regulation of gamma-delta T cell differentiation(GO:0045588)
0.0 0.1 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.3 GO:0019059 obsolete initiation of viral infection(GO:0019059)
0.0 0.1 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.2 GO:0045116 protein neddylation(GO:0045116)
0.0 0.1 GO:1904019 endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0 0.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.1 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 0.1 GO:0003351 epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.1 GO:0006106 fumarate metabolic process(GO:0006106)
0.0 0.0 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.1 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.0 0.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.1 GO:0006924 activation-induced cell death of T cells(GO:0006924)
0.0 0.1 GO:0032695 negative regulation of interleukin-12 production(GO:0032695)
0.0 0.1 GO:0030210 heparin biosynthetic process(GO:0030210)
0.0 0.0 GO:0002335 mature B cell differentiation(GO:0002335)
0.0 0.2 GO:0042362 fat-soluble vitamin biosynthetic process(GO:0042362)
0.0 0.1 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.0 0.1 GO:0048670 regulation of collateral sprouting(GO:0048670)
0.0 0.1 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 0.1 GO:0015959 diadenosine polyphosphate metabolic process(GO:0015959)
0.0 0.0 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 0.1 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.1 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.1 GO:0072216 positive regulation of metanephros development(GO:0072216)
0.0 0.1 GO:0021683 cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 0.2 GO:0006379 mRNA cleavage(GO:0006379)
0.0 0.0 GO:0003161 cardiac conduction system development(GO:0003161)
0.0 0.1 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 0.1 GO:0002507 tolerance induction(GO:0002507)
0.0 0.1 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.2 GO:0010324 phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0 0.1 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.0 0.4 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.1 GO:0043137 DNA replication, Okazaki fragment processing(GO:0033567) DNA replication, removal of RNA primer(GO:0043137)
0.0 0.1 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.1 GO:0002423 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0 0.1 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.1 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.0 GO:0032621 interleukin-18 production(GO:0032621) regulation of interleukin-18 production(GO:0032661)
0.0 0.0 GO:0071360 cellular response to exogenous dsRNA(GO:0071360)
0.0 0.1 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.0 GO:1901984 negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0 0.1 GO:0033160 positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0 0.1 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.0 0.1 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.0 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.0 0.1 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.0 0.1 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.0 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.1 GO:0006554 lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0 0.0 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0 0.0 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.0 GO:0045349 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.0 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.1 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.0 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.0 GO:0060972 left/right pattern formation(GO:0060972)
0.0 0.0 GO:0001821 histamine secretion(GO:0001821)
0.0 0.1 GO:0051319 mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0 0.3 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.0 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
0.0 0.1 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.0 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 0.0 GO:0006538 glutamate catabolic process(GO:0006538)
0.0 0.8 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.0 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.0 0.0 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.0 GO:0015801 aromatic amino acid transport(GO:0015801)
0.0 0.0 GO:0034616 response to laminar fluid shear stress(GO:0034616)
0.0 0.0 GO:2000400 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0 0.0 GO:0033629 negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0 0.1 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.1 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.0 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.2 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.0 GO:0045040 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.1 GO:0090205 positive regulation of cholesterol metabolic process(GO:0090205)
0.0 0.0 GO:0045359 interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.0 0.0 GO:0060539 diaphragm development(GO:0060539)
0.0 0.0 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.0 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.0 0.1 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.1 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)
0.0 0.0 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.1 GO:0006547 histidine metabolic process(GO:0006547)
0.0 0.0 GO:2000380 regulation of mesodermal cell fate specification(GO:0042661) regulation of mesoderm development(GO:2000380)
0.0 0.0 GO:0002093 auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.0 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.1 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.0 0.0 GO:0070102 interleukin-6-mediated signaling pathway(GO:0070102)
0.0 0.1 GO:0070536 protein K63-linked deubiquitination(GO:0070536)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0072487 MSL complex(GO:0072487)
0.1 0.2 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.2 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.4 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.2 GO:0071778 obsolete WINAC complex(GO:0071778)
0.0 0.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.2 GO:0031143 pseudopodium(GO:0031143)
0.0 0.2 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.1 GO:0017059 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.1 GO:0042629 mast cell granule(GO:0042629)
0.0 0.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.0 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.2 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.1 GO:0034464 BBSome(GO:0034464)
0.0 0.1 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.0 0.1 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0 0.1 GO:0016580 Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822)
0.0 0.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.0 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.0 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.0 GO:0070062 extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0 0.0 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.1 GO:0005869 dynactin complex(GO:0005869)
0.0 0.0 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.0 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.4 GO:0030175 filopodium(GO:0030175)
0.0 0.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.1 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.0 GO:0032009 early phagosome(GO:0032009)
0.0 0.0 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.1 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.1 GO:0001772 immunological synapse(GO:0001772)
0.0 0.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0000791 euchromatin(GO:0000791)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 0.5 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 0.2 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 0.2 GO:0050544 arachidonic acid binding(GO:0050544)
0.1 0.3 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.3 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 1.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.6 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.2 GO:0031701 angiotensin receptor binding(GO:0031701)
0.0 0.1 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.1 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 0.1 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.1 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.1 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.1 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.1 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.1 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.1 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.2 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.2 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.2 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.0 GO:0016748 succinyltransferase activity(GO:0016748)
0.0 0.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.1 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.0 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.1 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0 0.1 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.0 0.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.1 GO:0004437 obsolete inositol or phosphatidylinositol phosphatase activity(GO:0004437)
0.0 0.0 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.1 GO:0004340 glucokinase activity(GO:0004340)
0.0 0.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.1 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.0 0.1 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.0 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.0 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.0 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.1 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.0 0.0 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.0 0.0 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.0 0.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.1 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.0 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0 0.1 GO:0015288 porin activity(GO:0015288)
0.0 0.0 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.1 GO:0016778 diphosphotransferase activity(GO:0016778)
0.0 0.0 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.0 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.0 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.0 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.1 GO:0061659 ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 0.0 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
0.0 0.0 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 0.1 GO:0008139 nuclear localization sequence binding(GO:0008139)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.6 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.2 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.6 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 1.0 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.2 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.4 PID S1P S1P3 PATHWAY S1P3 pathway
0.0 0.3 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.3 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.2 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.2 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.6 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.1 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.0 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.1 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.1 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.2 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.5 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.1 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.2 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.3 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.4 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.0 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.0 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.0 0.4 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.3 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.2 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.2 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.0 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0 0.0 REACTOME SIGNAL AMPLIFICATION Genes involved in Signal amplification
0.0 0.7 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.0 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.3 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.0 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.2 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.1 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.1 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.0 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.1 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.0 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.0 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.1 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.2 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)