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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for DLX5

Z-value: 0.79

Motif logo

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Transcription factors associated with DLX5

Gene Symbol Gene ID Gene Info
DLX5
ENSG00000105880.4 distal-less homeobox 5

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr7_96654173_96654357DLX530.973536-0.693.8e-02Click!
chr7_96653818_96654015DLX53460.856351-0.599.7e-02Click!
chr7_96653221_96653741DLX57810.596408-0.501.7e-01Click!
chr7_96656161_96656312DLX518270.3032650.462.1e-01Click!
chr7_96656340_96657076DLX522990.2565250.432.5e-01Click!

Activity of the DLX5 motif across conditions

Conditions sorted by the z-value of the DLX5 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr7_26141262_26141558 0.58 ENSG00000266430
 .
 41451
 0.15
chr1_66799510_66799957 0.54 PDE4B
 phosphodiesterase 4B, cAMP-specific
 1861
 0.5
chrX_19815653_19816006 0.47 SH3KBP1
 SH3-domain kinase binding protein 1
 2040
 0.46
chrX_78400540_78401325 0.46 GPR174
 G protein-coupled receptor 174
 25537
 0.27
chr1_112018691_112018961 0.43 C1orf162
 chromosome 1 open reading frame 162
 2335
 0.16
chr1_9713063_9713437 0.42 C1orf200
 chromosome 1 open reading frame 200
 1394
 0.31
chr21_15917916_15918619 0.42 SAMSN1
 SAM domain, SH3 domain and nuclear localization signals 1
 395
 0.89
chr1_111741177_111741444 0.40 DENND2D
 DENN/MADD domain containing 2D
 2001
 0.2
chr20_56194431_56194643 0.39 ZBP1
 Z-DNA binding protein 1
 913
 0.65
chr11_65324098_65324348 0.39 LTBP3
 latent transforming growth factor beta binding protein 3
 1013
 0.31
chr1_239883177_239883989 0.37 CHRM3
 cholinergic receptor, muscarinic 3
 740
 0.59
chr3_108543496_108543820 0.35 TRAT1
 T cell receptor associated transmembrane adaptor 1
 2039
 0.42
chr15_65587802_65587963 0.35 ENSG00000199568
 .
 507
 0.7
chr6_135518404_135518725 0.34 MYB-AS1
 MYB antisense RNA 1
 1431
 0.4
chr1_162843054_162843205 0.33 C1orf110
 chromosome 1 open reading frame 110
 4524
 0.29
chr13_99957828_99957979 0.31 GPR183
 G protein-coupled receptor 183
 1756
 0.38
chr17_29639732_29640055 0.31 EVI2B
 ecotropic viral integration site 2B
 1209
 0.36
chr1_66802476_66802627 0.31 PDE4B
 phosphodiesterase 4B, cAMP-specific
 4679
 0.34
chr2_62426916_62427067 0.31 B3GNT2
 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
 3743
 0.21
chr12_866633_866784 0.31 WNK1
 WNK lysine deficient protein kinase 1
 3976
 0.25
chr3_121378552_121379115 0.30 HCLS1
 hematopoietic cell-specific Lyn substrate 1
 912
 0.5
chr5_14560333_14560610 0.30 FAM105A
 family with sequence similarity 105, member A
 21413
 0.23
chr4_119143007_119143249 0.30 ENSG00000269893
 .
 57217
 0.16
chr17_4615230_4615381 0.29 ARRB2
 arrestin, beta 2
 1311
 0.23
chr2_85076559_85076967 0.28 TRABD2A
 TraB domain containing 2A
 31443
 0.16
chr5_43017766_43018004 0.28 CTD-2035E11.3
646
 0.52
chr5_110560941_110561277 0.28 CAMK4
 calcium/calmodulin-dependent protein kinase IV
 1325
 0.51
chr15_94815577_94815728 0.28 MCTP2
 multiple C2 domains, transmembrane 2
 25778
 0.28
chr3_186745077_186745229 0.28 ST6GAL1
 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
 1882
 0.42
chr18_13216452_13216669 0.27 RP11-794M8.1
194
 0.92
chr17_25622078_25622646 0.27 WSB1
 WD repeat and SOCS box containing 1
 990
 0.48
chr13_27234189_27234340 0.27 WASF3-AS1
 WASF3 antisense RNA 1
 18763
 0.26
chr13_21050204_21050392 0.27 ENSG00000263978
 .
 42313
 0.15
chr15_55547653_55548107 0.27 RAB27A
 RAB27A, member RAS oncogene family
 6647
 0.22
chr11_14097018_14097169 0.26 ENSG00000212365
 .
 59439
 0.15
chr2_47537091_47537242 0.26 EPCAM
 epithelial cell adhesion molecule
 35131
 0.15
chr1_53068469_53068939 0.26 GPX7
 glutathione peroxidase 7
 660
 0.7
chr10_11217828_11218013 0.26 RP3-323N1.2
4581
 0.25
chr5_60626384_60626783 0.26 ZSWIM6
 zinc finger, SWIM-type containing 6
 1517
 0.55
chrX_8150685_8150836 0.25 VCX2
 variable charge, X-linked 2
 11452
 0.28
chrX_30594869_30596024 0.25 CXorf21
 chromosome X open reading frame 21
 515
 0.84
chr12_75877051_75877218 0.25 GLIPR1
 GLI pathogenesis-related 1
 2150
 0.29
chr11_122597673_122598179 0.25 ENSG00000239079
 .
 907
 0.67
chr12_75875359_75875792 0.25 GLIPR1
 GLI pathogenesis-related 1
 591
 0.74
chr17_40400288_40400799 0.24 RP11-358B23.5
20062
 0.1
chr9_95730621_95730837 0.24 FGD3
 FYVE, RhoGEF and PH domain containing 3
 4486
 0.25
chr10_126745966_126746179 0.24 ENSG00000264572
 .
 24633
 0.19
chr12_120976273_120976798 0.24 RNF10
 ring finger protein 10
 3306
 0.14
chr15_100881986_100882218 0.24 ADAMTS17
 ADAM metallopeptidase with thrombospondin type 1 motif, 17
 108
 0.98
chr20_8349746_8349924 0.23 PLCB1-IT1
 PLCB1 intronic transcript 1 (non-protein coding)
 120463
 0.06
chr18_9404580_9404814 0.23 TWSG1
 twisted gastrulation BMP signaling modulator 1
 69849
 0.08
chr12_104854519_104854691 0.23 CHST11
 carbohydrate (chondroitin 4) sulfotransferase 11
 3826
 0.33
chr7_150436038_150436258 0.23 GIMAP5
 GTPase, IMAP family member 5
 1712
 0.32
chr11_128343021_128343263 0.23 ETS1
 v-ets avian erythroblastosis virus E26 oncogene homolog 1
 32147
 0.21
chr19_50062782_50062933 0.23 NOSIP
 nitric oxide synthase interacting protein
 1030
 0.27
chr1_47726053_47726204 0.23 STIL
 SCL/TAL1 interrupting locus
 20601
 0.14
chr9_131453430_131453735 0.23 SET
 SET nuclear oncogene
 1314
 0.27
chr3_119880714_119880865 0.22 ENSG00000244139
 .
 40033
 0.13
chr14_77873229_77873401 0.22 FKSG61
9426
 0.11
chr3_111263576_111263727 0.22 CD96
 CD96 molecule
 2654
 0.36
chr2_25500266_25500584 0.22 DNMT3A
 DNA (cytosine-5-)-methyltransferase 3 alpha
 25245
 0.19
chr5_156476977_156477197 0.22 HAVCR1
 hepatitis A virus cellular receptor 1
 8320
 0.2
chr11_2322356_2322739 0.22 C11orf21
 chromosome 11 open reading frame 21
 596
 0.44
chr4_175041157_175041343 0.22 FBXO8
 F-box protein 8
 163564
 0.04
chr3_63954713_63955178 0.22 ATXN7
 ataxin 7
 1525
 0.34
chrX_40440586_40440827 0.22 ATP6AP2
 ATPase, H+ transporting, lysosomal accessory protein 2
 443
 0.86
chr2_44133691_44133842 0.22 LRPPRC
 leucine-rich pentatricopeptide repeat containing
 7343
 0.2
chr8_66742389_66742540 0.21 PDE7A
 phosphodiesterase 7A
 8519
 0.29
chr6_32158116_32158500 0.21 PBX2
 pre-B-cell leukemia homeobox 2
 345
 0.7
chr11_75063727_75063930 0.21 ARRB1
 arrestin, beta 1
 955
 0.48
chr8_39797291_39797650 0.21 IDO2
 indoleamine 2,3-dioxygenase 2
 4996
 0.18
chr6_41650642_41650943 0.21 AL035588.1
3172
 0.18
chr1_204482801_204482952 0.21 MDM4
 Mdm4 p53 binding protein homolog (mouse)
 2635
 0.26
chr12_11803298_11803449 0.21 ETV6
 ets variant 6
 585
 0.83
chr2_25473265_25473416 0.21 DNMT3A
 DNA (cytosine-5-)-methyltransferase 3 alpha
 1840
 0.39
chr11_14995196_14995439 0.21 CALCA
 calcitonin-related polypeptide alpha
 1417
 0.53
chr18_66381478_66381997 0.21 TMX3
 thioredoxin-related transmembrane protein 3
 557
 0.55
chr10_75935885_75936201 0.21 ADK
 adenosine kinase
 401
 0.88
chr1_179856871_179857022 0.20 TOR1AIP1
 torsin A interacting protein 1
 4922
 0.16
chr8_102802981_102803132 0.20 NCALD
 neurocalcin delta
 119
 0.98
chr15_75080868_75081404 0.20 ENSG00000264386
 .
 38
 0.76
chr4_109056842_109056993 0.20 LEF1
 lymphoid enhancer-binding factor 1
 30540
 0.19
chr12_11802043_11802302 0.20 ETV6
 ets variant 6
 616
 0.81
chr13_41555714_41555943 0.20 ELF1
 E74-like factor 1 (ets domain transcription factor)
 590
 0.77
chr15_57210828_57211163 0.20 TCF12
 transcription factor 12
 35
 0.75
chr6_126068689_126068849 0.20 HEY2
 hes-related family bHLH transcription factor with YRPW motif 2
 41
 0.97
chr4_84035334_84035716 0.20 PLAC8
 placenta-specific 8
 343
 0.91
chr14_22974481_22974956 0.20 TRAJ51
 T cell receptor alpha joining 51 (pseudogene)
 18547
 0.09
chr5_118606012_118606179 0.20 TNFAIP8
 tumor necrosis factor, alpha-induced protein 8
 1646
 0.37
chr1_27115315_27115664 0.20 PIGV
 phosphatidylinositol glycan anchor biosynthesis, class V
 70
 0.96
chr6_107154119_107154270 0.20 ENSG00000202285
 .
 32735
 0.17
chr2_88124610_88124761 0.20 RGPD2
 RANBP2-like and GRIP domain containing 2
 601
 0.82
chr22_41033042_41033281 0.20 MKL1
 megakaryoblastic leukemia (translocation) 1
 466
 0.84
chr1_153918448_153918692 0.20 DENND4B
 DENN/MADD domain containing 4B
 602
 0.54
chr1_214484548_214484699 0.20 SMYD2
 SET and MYND domain containing 2
 19697
 0.24
chr15_61013382_61013533 0.19 ENSG00000212625
 .
 15511
 0.2
chr1_169676400_169676585 0.19 SELL
 selectin L
 4347
 0.23
chr12_51818248_51818602 0.19 RP11-607P23.1
30
 0.62
chr17_75456326_75456913 0.19 SEPT9
 septin 9
 4171
 0.18
chr13_41164420_41164571 0.19 AL133318.1
 Uncharacterized protein
 53172
 0.14
chr19_46194641_46194820 0.19 SNRPD2
 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa
 299
 0.72
chr22_40858929_40859404 0.19 MKL1
 megakaryoblastic leukemia (translocation) 1
 256
 0.92
chr3_136537398_136537875 0.19 SLC35G2
 solute carrier family 35, member G2
 225
 0.92
chr17_45725211_45725362 0.19 RP11-580I16.2
1482
 0.26
chr6_24934739_24934890 0.19 FAM65B
 family with sequence similarity 65, member B
 1374
 0.5
chr5_169708113_169708278 0.19 LCP2
 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
 13864
 0.22
chr14_22447473_22447624 0.19 ENSG00000238634
 .
 163339
 0.03
chr1_65096460_65096611 0.19 ENSG00000264470
 .
 51005
 0.17
chr6_2222723_2222882 0.19 GMDS
 GDP-mannose 4,6-dehydratase
 23124
 0.28
chr1_150737696_150737976 0.19 CTSS
 cathepsin S
 432
 0.77
chr11_61158553_61158704 0.18 TMEM216
 transmembrane protein 216
 531
 0.65
chr2_161995257_161995554 0.18 TANK
 TRAF family member-associated NFKB activator
 1939
 0.4
chr17_81147907_81148162 0.18 METRNL
 meteorin, glial cell differentiation regulator-like
 96040
 0.08
chr11_60928486_60928645 0.18 VPS37C
 vacuolar protein sorting 37 homolog C (S. cerevisiae)
 43
 0.97
chr1_244999063_244999557 0.18 COX20
 COX20 cytochrome C oxidase assembly factor
 392
 0.85
chr10_12238316_12238700 0.18 CDC123
 cell division cycle 123
 277
 0.57
chrX_64196083_64196443 0.18 ZC4H2
 zinc finger, C4H2 domain containing
 65
 0.99
chr22_22121341_22121492 0.18 ENSG00000200985
 .
 25307
 0.12
chrX_54557248_54557562 0.18 GNL3L
 guanine nucleotide binding protein-like 3 (nucleolar)-like
 730
 0.73
chr3_12228694_12228845 0.18 TIMP4
 TIMP metallopeptidase inhibitor 4
 27918
 0.22
chr17_1811216_1811594 0.18 RPA1
 replication protein A1, 70kDa
 29076
 0.13
chrX_78200973_78201449 0.18 P2RY10
 purinergic receptor P2Y, G-protein coupled, 10
 293
 0.95
chr4_39979745_39980089 0.18 PDS5A
 PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
 341
 0.9
chr5_58883529_58883730 0.18 PDE4D
 phosphodiesterase 4D, cAMP-specific
 1304
 0.62
chr8_128988445_128988635 0.18 ENSG00000221771
 .
 15661
 0.16
chr21_45341679_45341830 0.17 ENSG00000199598
 .
 1972
 0.29
chrX_78202204_78202379 0.17 P2RY10
 purinergic receptor P2Y, G-protein coupled, 10
 1373
 0.61
chr1_79322114_79322265 0.17 ELTD1
 EGF, latrophilin and seven transmembrane domain containing 1
 61381
 0.15
chr16_23265949_23266165 0.17 CTC-391G2.1
41632
 0.14
chr12_131796680_131796831 0.17 ENSG00000212251
 .
 12459
 0.23
chr9_130823963_130824114 0.17 RP11-379C10.1
4397
 0.11
chr14_31879526_31879677 0.17 HEATR5A
 HEAT repeat containing 5A
 7420
 0.17
chr19_13859245_13859441 0.17 CCDC130
 coiled-coil domain containing 130
 632
 0.57
chr1_183843426_183843577 0.17 RGL1
 ral guanine nucleotide dissociation stimulator-like 1
 69211
 0.11
chr7_150267315_150267508 0.17 GIMAP4
 GTPase, IMAP family member 4
 2887
 0.27
chr6_76203613_76203764 0.17 FILIP1
 filamin A interacting protein 1
 234
 0.93
chrX_118751905_118752056 0.17 NKRF
 NFKB repressing factor
 12122
 0.15
chr6_2854275_2854463 0.17 ENSG00000266750
 .
 28
 0.98
chr3_30673309_30673499 0.17 TGFBR2
 transforming growth factor, beta receptor II (70/80kDa)
 25311
 0.24
chr20_43599792_43600332 0.17 STK4
 serine/threonine kinase 4
 4895
 0.16
chr1_206646546_206646697 0.17 IKBKE
 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
 2783
 0.21
chr1_51442241_51442392 0.17 CDKN2C
 cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
 6700
 0.22
chr20_3388735_3389323 0.17 C20orf194
 chromosome 20 open reading frame 194
 757
 0.58
chr3_64326564_64326736 0.17 PRICKLE2
 prickle homolog 2 (Drosophila)
 72995
 0.11
chr13_75898854_75899075 0.17 TBC1D4
 TBC1 domain family, member 4
 16703
 0.24
chr8_82597903_82598285 0.17 IMPA1
 inositol(myo)-1(or 4)-monophosphatase 1
 27
 0.97
chr21_36308793_36309139 0.17 RUNX1
 runt-related transcription factor 1
 46879
 0.19
chr14_62170526_62170677 0.17 HIF1A
 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
 6261
 0.26
chr15_60874237_60874501 0.17 RORA
 RAR-related orphan receptor A
 10371
 0.22
chr7_145332771_145332922 0.16 ENSG00000264018
 .
 460334
 0.01
chr3_152878700_152878913 0.16 RP11-529G21.2
758
 0.56
chr17_29359555_29359720 0.16 RP11-271K11.5
18407
 0.11
chrX_102508933_102509363 0.16 TCEAL8
 transcription elongation factor A (SII)-like 8
 965
 0.51
chr12_12874334_12874808 0.16 RP11-180M15.4
2374
 0.2
chr9_100565871_100566193 0.16 FOXE1
 forkhead box E1 (thyroid transcription factor 2)
 49504
 0.13
chr10_30756907_30757058 0.16 MAP3K8
 mitogen-activated protein kinase kinase kinase 8
 29231
 0.19
chr9_120468751_120468935 0.16 ENSG00000201444
 .
 1537
 0.37
chr3_128950544_128950778 0.16 COPG1
 coatomer protein complex, subunit gamma 1
 17788
 0.14
chr7_6522650_6523366 0.16 FLJ20306
 CDNA FLJ20306 fis, clone HEP06881; Putative uncharacterized protein FLJ20306; Uncharacterized protein
 86
 0.87
chr17_80817564_80818630 0.16 TBCD
 tubulin folding cofactor D
 173
 0.94
chr6_26204271_26204655 0.16 HIST1H4E
 histone cluster 1, H4e
 395
 0.59
chr9_88897597_88898295 0.16 ISCA1
 iron-sulfur cluster assembly 1
 270
 0.91
chr4_183525693_183525844 0.16 ENSG00000251714
 .
 27073
 0.21
chr1_162467642_162468629 0.16 UHMK1
 U2AF homology motif (UHM) kinase 1
 502
 0.8
chr9_75766606_75766757 0.16 ANXA1
 annexin A1
 8
 0.99
chr9_36573868_36574019 0.16 MELK
 maternal embryonic leucine zipper kinase
 1035
 0.67
chr8_16211740_16211891 0.16 MSR1
 macrophage scavenger receptor 1
 139232
 0.05
chr8_74283688_74283839 0.16 RP11-434I12.2
15067
 0.24
chr15_31634841_31635126 0.16 KLF13
 Kruppel-like factor 13
 2847
 0.4
chr1_245215084_245215235 0.16 ENSG00000251754
 .
 7929
 0.17
chr10_47640402_47640757 0.16 ANTXRLP1
 anthrax toxin receptor-like pseudogene 1
 4212
 0.25
chr1_89992055_89992206 0.16 LRRC8B
 leucine rich repeat containing 8 family, member B
 1668
 0.45
chr13_74818552_74818703 0.16 ENSG00000206617
 .
 44724
 0.19
chr11_122040052_122040217 0.16 ENSG00000207994
 .
 17118
 0.17
chr8_66843866_66844135 0.16 DNAJC5B
 DnaJ (Hsp40) homolog, subfamily C, member 5 beta
 89795
 0.08
chrX_150564855_150565441 0.16 VMA21
 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
 110
 0.98
chr3_57162010_57162273 0.16 IL17RD
 interleukin 17 receptor D
 14378
 0.18
chr8_8204138_8204819 0.16 SGK223
 Tyrosine-protein kinase SgK223
 34779
 0.19
chr7_135656834_135656985 0.16 MTPN
 myotrophin
 5155
 0.19
chr20_36040358_36040543 0.16 SRC
 v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
 27897
 0.21
chr3_18478950_18479101 0.16 SATB1
 SATB homeobox 1
 1159
 0.53
chr6_136824219_136824370 0.16 MAP7
 microtubule-associated protein 7
 22827
 0.18
chr1_27463127_27463278 0.16 SLC9A1
 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
 17771
 0.19
chr13_31310422_31310683 0.16 ALOX5AP
 arachidonate 5-lipoxygenase-activating protein
 907
 0.71
chr7_102531578_102531729 0.16 LRRC17
 leucine rich repeat containing 17
 21785
 0.16
chr1_247553346_247553582 0.16 NLRP3
 NLR family, pyrin domain containing 3
 25994
 0.15
chr1_2478602_2479100 0.16 TNFRSF14
 tumor necrosis factor receptor superfamily, member 14
 8227
 0.09
chr8_134081639_134081790 0.15 SLA
 Src-like-adaptor
 9111
 0.25
chr5_68338922_68339492 0.15 SLC30A5
 solute carrier family 30 (zinc transporter), member 5
 50266
 0.12
chr1_64977342_64977493 0.15 CACHD1
 cache domain containing 1
 40942
 0.18
chr3_71349536_71349687 0.15 FOXP1
 forkhead box P1
 4300
 0.28
chr20_36543212_36543480 0.15 VSTM2L
 V-set and transmembrane domain containing 2 like
 11802
 0.23
chr12_2754166_2754317 0.15 CACNA1C-AS2
 CACNA1C antisense RNA 2
 27145
 0.16
chr5_75600050_75600201 0.15 RP11-466P24.6
7162
 0.3
chr10_126835424_126835575 0.15 CTBP2
 C-terminal binding protein 2
 11786
 0.28
chr18_60982497_60982692 0.15 RP11-28F1.2
1279
 0.41
chr15_60420104_60420458 0.15 FOXB1
 forkhead box B1
 123860
 0.06
chr4_154411300_154411567 0.15 KIAA0922
 KIAA0922
 23932
 0.22
chr3_53288776_53289025 0.15 TKT
 transketolase
 1116
 0.42
chr6_46097188_46097569 0.15 RP1-8B1.4
50
 0.84

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of DLX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 0.2 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1 0.3 GO:0006924 activation-induced cell death of T cells(GO:0006924)
0.1 0.3 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
0.1 0.2 GO:0009215 purine deoxyribonucleoside triphosphate metabolic process(GO:0009215)
0.1 0.1 GO:0033629 negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.1 0.2 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.1 0.2 GO:0010447 response to acidic pH(GO:0010447)
0.1 0.2 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.1 0.2 GO:0052033 pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308)
0.0 0.1 GO:1900120 regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.0 0.2 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.0 0.1 GO:0019372 lipoxygenase pathway(GO:0019372)
0.0 0.2 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.3 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.0 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.0 0.3 GO:0071545 inositol phosphate catabolic process(GO:0071545)
0.0 0.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.3 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.2 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0 0.1 GO:0032506 cytokinetic process(GO:0032506)
0.0 0.1 GO:0002323 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0 0.1 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.1 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.0 0.2 GO:0002063 chondrocyte development(GO:0002063)
0.0 0.1 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0 0.0 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0 0.1 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.0 0.2 GO:0070071 proton-transporting two-sector ATPase complex assembly(GO:0070071)
0.0 0.1 GO:0032730 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730)
0.0 0.1 GO:0045066 regulatory T cell differentiation(GO:0045066)
0.0 0.1 GO:0043045 DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.0 0.1 GO:2000351 endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0 0.1 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.1 GO:0002327 immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.0 0.1 GO:0044380 protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0 0.1 GO:2000380 regulation of mesodermal cell fate specification(GO:0042661) regulation of mesoderm development(GO:2000380)
0.0 0.1 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.2 GO:0015671 oxygen transport(GO:0015671)
0.0 0.1 GO:0042494 detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0 0.1 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.1 GO:0097709 connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0 0.1 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.0 0.2 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.1 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.1 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.1 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0 0.1 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.0 GO:0045978 negative regulation of nucleoside metabolic process(GO:0045978) negative regulation of ATP metabolic process(GO:1903579)
0.0 0.1 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 0.1 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.0 0.1 GO:2000758 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.1 GO:0034214 protein hexamerization(GO:0034214)
0.0 0.1 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.0 0.0 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 0.1 GO:0005997 xylulose metabolic process(GO:0005997)
0.0 0.1 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.0 0.1 GO:0045056 transcytosis(GO:0045056)
0.0 0.1 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.1 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:0033160 positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0 0.0 GO:0072367 regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0 0.1 GO:0048643 positive regulation of skeletal muscle tissue development(GO:0048643)
0.0 0.1 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.1 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.1 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.0 0.2 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 0.1 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.1 GO:1901984 negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0 0.1 GO:0030952 establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.0 0.1 GO:0010452 histone H3-K36 methylation(GO:0010452)
0.0 0.1 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.1 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.0 0.2 GO:0001556 oocyte maturation(GO:0001556)
0.0 0.1 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.1 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.1 GO:0006578 amino-acid betaine biosynthetic process(GO:0006578) carnitine biosynthetic process(GO:0045329)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.0 GO:0009151 purine deoxyribonucleotide metabolic process(GO:0009151)
0.0 0.1 GO:0032354 response to follicle-stimulating hormone(GO:0032354)
0.0 0.0 GO:0007549 dosage compensation(GO:0007549)
0.0 0.1 GO:0001782 B cell homeostasis(GO:0001782)
0.0 0.0 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.0 0.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.3 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 0.0 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.0 0.1 GO:0050651 dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0 0.1 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.1 GO:0090047 obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0 0.0 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.0 0.0 GO:0009173 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0 0.1 GO:0006349 regulation of gene expression by genetic imprinting(GO:0006349)
0.0 0.0 GO:0010891 negative regulation of sequestering of triglyceride(GO:0010891)
0.0 0.0 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.0 0.0 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.0 0.0 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.1 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.0 0.1 GO:0045357 interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.0 0.0 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 0.0 GO:1903224 endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0 0.0 GO:0032060 bleb assembly(GO:0032060)
0.0 0.0 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.0 0.0 GO:0046931 pore complex assembly(GO:0046931)
0.0 0.1 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.1 GO:1901532 regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0 0.0 GO:0043497 regulation of protein heterodimerization activity(GO:0043497)
0.0 0.1 GO:0060539 diaphragm development(GO:0060539)
0.0 0.2 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.1 GO:0000730 DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0 0.0 GO:1904936 interneuron migration from the subpallium to the cortex(GO:0021830) cerebral cortex GABAergic interneuron migration(GO:0021853) cerebral cortex GABAergic interneuron development(GO:0021894) interneuron migration(GO:1904936)
0.0 0.0 GO:0022605 oogenesis stage(GO:0022605)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.0 GO:0048670 regulation of collateral sprouting(GO:0048670)
0.0 0.0 GO:0031062 positive regulation of histone methylation(GO:0031062)
0.0 0.0 GO:0021571 rhombomere 5 development(GO:0021571)
0.0 0.0 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.0 0.0 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.0 GO:0002328 pro-B cell differentiation(GO:0002328)
0.0 0.0 GO:0046101 hypoxanthine biosynthetic process(GO:0046101)
0.0 0.1 GO:1901663 quinone biosynthetic process(GO:1901663)
0.0 0.0 GO:0002019 regulation of renal output by angiotensin(GO:0002019)
0.0 0.0 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.0 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.0 GO:0030210 heparin biosynthetic process(GO:0030210)
0.0 0.1 GO:0007035 vacuolar acidification(GO:0007035)
0.0 0.0 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.1 GO:0006547 histidine metabolic process(GO:0006547)
0.0 0.1 GO:0045730 respiratory burst(GO:0045730)
0.0 0.0 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.0 0.0 GO:0030187 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0 0.0 GO:0000239 pachytene(GO:0000239)
0.0 0.1 GO:0007341 penetration of zona pellucida(GO:0007341)
0.0 0.0 GO:0050685 positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0 0.0 GO:1902745 positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0 0.0 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 0.0 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.0 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.0 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.0 GO:0071034 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0 0.1 GO:0006554 lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0 0.0 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.0 0.1 GO:0055070 copper ion homeostasis(GO:0055070)
0.0 0.0 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.0 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.3 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.2 GO:0000791 euchromatin(GO:0000791)
0.0 0.2 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.2 GO:0032279 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0 0.1 GO:0000800 lateral element(GO:0000800)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.0 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.1 GO:0001739 sex chromatin(GO:0001739)
0.0 0.7 GO:0005626 obsolete insoluble fraction(GO:0005626)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.1 GO:0016939 kinesin II complex(GO:0016939)
0.0 0.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.2 GO:0030130 trans-Golgi network transport vesicle membrane(GO:0012510) clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.1 GO:0001740 Barr body(GO:0001740)
0.0 0.1 GO:0005827 polar microtubule(GO:0005827)
0.0 0.1 GO:0071778 obsolete WINAC complex(GO:0071778)
0.0 0.1 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.1 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.1 GO:0031143 pseudopodium(GO:0031143)
0.0 0.1 GO:0000125 PCAF complex(GO:0000125)
0.0 0.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.1 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.0 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.0 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0034464 BBSome(GO:0034464)
0.0 0.0 GO:0042629 mast cell granule(GO:0042629)
0.0 0.1 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.1 GO:0005869 dynactin complex(GO:0005869)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)
0.0 0.1 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.1 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.0 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.1 GO:0061200 clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.2 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.1 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.0 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.0 GO:0032009 early phagosome(GO:0032009)
0.0 0.3 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.1 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.0 0.0 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.1 GO:0042598 obsolete vesicular fraction(GO:0042598)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1 0.2 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.1 0.2 GO:0008934 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.1 0.2 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.1 0.3 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1 0.2 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.3 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.1 GO:0050544 arachidonic acid binding(GO:0050544)
0.0 0.1 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0 0.0 GO:0045159 myosin II binding(GO:0045159)
0.0 0.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.3 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.9 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.2 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.2 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.2 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.1 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.2 GO:0031701 angiotensin receptor binding(GO:0031701)
0.0 0.1 GO:0043175 RNA polymerase core enzyme binding(GO:0043175)
0.0 0.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0098847 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.2 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.1 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.1 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.2 GO:0030276 clathrin binding(GO:0030276)
0.0 0.1 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0004802 transketolase activity(GO:0004802)
0.0 0.3 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.1 GO:0004738 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.1 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.2 GO:0019206 nucleoside kinase activity(GO:0019206)
0.0 0.1 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.1 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.1 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0 0.2 GO:0030332 cyclin binding(GO:0030332)
0.0 0.0 GO:0034711 inhibin binding(GO:0034711)
0.0 0.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.1 GO:0016362 activin receptor activity, type II(GO:0016362)
0.0 0.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.1 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.1 GO:0035198 miRNA binding(GO:0035198)
0.0 0.0 GO:0071723 lipopeptide binding(GO:0071723)
0.0 0.1 GO:0004568 chitinase activity(GO:0004568)
0.0 0.1 GO:0046980 tapasin binding(GO:0046980)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.2 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.0 GO:0000404 heteroduplex DNA loop binding(GO:0000404)
0.0 0.0 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.0 0.0 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.0 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.0 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.1 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.2 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.0 GO:0050542 icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0 0.0 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.0 0.1 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.1 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 0.1 GO:0061659 ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 0.3 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.1 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.0 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.0 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.1 GO:0042171 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 0.0 GO:0016748 succinyltransferase activity(GO:0016748)
0.0 0.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.1 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.1 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.0 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0 0.0 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.0 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.1 GO:0019894 kinesin binding(GO:0019894)
0.0 0.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.0 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.1 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0 0.1 GO:0046625 sphingolipid binding(GO:0046625)
0.0 0.1 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.0 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.6 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.5 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.6 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.0 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.4 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.1 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.1 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.1 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.6 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.5 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.1 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.1 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.2 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.1 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.0 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0 0.2 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.0 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 0.2 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.3 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.6 REACTOME TCR SIGNALING Genes involved in TCR signaling
0.0 0.1 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.1 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.2 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.0 REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B Genes involved in APC/C:Cdc20 mediated degradation of Cyclin B
0.0 0.0 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.0 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.3 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway