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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for DMC1

Z-value: 0.83

Motif logo

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Transcription factors associated with DMC1

Gene Symbol Gene ID Gene Info
DMC1
ENSG00000100206.5 DNA meiotic recombinase 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr22_38966531_38967313DMC16310.677684-0.599.3e-02Click!
chr22_38965920_38966142DMC11050.960556-0.501.7e-01Click!
chr22_38965750_38965911DMC13060.877472-0.462.1e-01Click!

Activity of the DMC1 motif across conditions

Conditions sorted by the z-value of the DMC1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr5_36302041_36302306 0.36 RANBP3L
 RAN binding protein 3-like
 43
 0.98
chr4_183481639_183481857 0.35 ENSG00000252343
 .
 11936
 0.26
chr7_130591247_130591471 0.33 ENSG00000226380
 .
 29061
 0.21
chr1_63190926_63191187 0.32 RP11-230B22.1
36903
 0.16
chr15_80364416_80364822 0.31 ZFAND6
 zinc finger, AN1-type domain 6
 287
 0.93
chr15_42082923_42083265 0.30 AC073657.1
 Uncharacterized protein
 6865
 0.12
chr12_889349_889584 0.29 ENSG00000221439
 .
 833
 0.66
chr2_102374666_102374817 0.29 MAP4K4
 mitogen-activated protein kinase kinase kinase kinase 4
 38985
 0.21
chr17_74142136_74142287 0.29 RNF157-AS1
 RNF157 antisense RNA 1
 4614
 0.13
chr4_109347461_109347695 0.28 ENSG00000266046
 .
 150718
 0.04
chr21_38352575_38353327 0.28 HLCS
 holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
 23
 0.97
chr5_38650925_38651503 0.28 LIFR
 leukemia inhibitory factor receptor alpha
 55708
 0.13
chr5_38844869_38845152 0.27 OSMR
 oncostatin M receptor
 950
 0.68
chr6_53480929_53481080 0.27 GCLC
 glutamate-cysteine ligase, catalytic subunit
 764
 0.66
chr2_227598429_227598675 0.27 IRS1
 insulin receptor substrate 1
 65923
 0.11
chr1_215739347_215739498 0.27 KCTD3
 potassium channel tetramerization domain containing 3
 1313
 0.59
chr12_109248389_109248808 0.27 SSH1
 slingshot protein phosphatase 1
 2761
 0.21
chr7_97987211_97987389 0.26 RP11-307C18.1
35135
 0.15
chr8_59962698_59962849 0.26 RP11-328K2.1
57276
 0.12
chr4_90674169_90674343 0.26 RP11-115D19.1
71593
 0.11
chr3_152314332_152314547 0.25 RP11-362A9.3
99837
 0.08
chr18_7618536_7618784 0.25 PTPRM
 protein tyrosine phosphatase, receptor type, M
 50843
 0.16
chr19_50031610_50031873 0.24 RCN3
 reticulocalbin 3, EF-hand calcium binding domain
 142
 0.87
chr4_187765290_187765672 0.24 ENSG00000252382
 .
 13129
 0.29
chr1_83285095_83285395 0.24 LPHN2
 latrophilin 2
 839672
 0.0
chr20_32158375_32158526 0.24 CBFA2T2
 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
 8264
 0.19
chr7_22538999_22539909 0.24 STEAP1B
 STEAP family member 1B
 342
 0.91
chr3_135885490_135885641 0.24 MSL2
 male-specific lethal 2 homolog (Drosophila)
 27831
 0.21
chr1_243990574_243990792 0.23 AKT3
 v-akt murine thymoma viral oncogene homolog 3
 15855
 0.22
chr14_99614015_99614166 0.23 AL162151.4
10663
 0.28
chr7_116151462_116151613 0.23 CAV2
 caveolin 2
 11703
 0.15
chr5_96000350_96000501 0.23 CAST
 calpastatin
 1668
 0.37
chr2_233497598_233498235 0.23 EFHD1
 EF-hand domain family, member D1
 22
 0.97
chr6_5498765_5499077 0.22 RP1-232P20.1
40613
 0.2
chr2_16817553_16817704 0.22 FAM49A
 family with sequence similarity 49, member A
 13284
 0.3
chr5_9534352_9534503 0.22 CTD-2201E9.2
11137
 0.18
chr12_116892640_116892791 0.22 ENSG00000264037
 .
 26592
 0.24
chr3_190063110_190063261 0.21 CLDN1
 claudin 1
 22921
 0.21
chr10_63642613_63642764 0.21 ARID5B
 AT rich interactive domain 5B (MRF1-like)
 18371
 0.24
chr10_97049571_97049740 0.21 PDLIM1
 PDZ and LIM domain 1
 1126
 0.58
chr22_44608120_44608309 0.21 PARVG
 parvin, gamma
 30473
 0.22
chr14_70140824_70141065 0.21 SRSF5
 serine/arginine-rich splicing factor 5
 52673
 0.13
chr13_26623410_26623899 0.21 SHISA2
 shisa family member 2
 1515
 0.52
chr13_71953353_71953512 0.21 DACH1
 dachshund homolog 1 (Drosophila)
 487475
 0.01
chr9_133721695_133722074 0.21 ABL1
 c-abl oncogene 1, non-receptor tyrosine kinase
 11431
 0.21
chr20_46110875_46111026 0.21 ENSG00000202186
 .
 2175
 0.28
chr13_99880901_99881195 0.20 ENSG00000201793
 .
 23086
 0.16
chr5_107767649_107767800 0.20 FBXL17
 F-box and leucine-rich repeat protein 17
 49925
 0.19
chr5_112823124_112823740 0.20 MCC
 mutated in colorectal cancers
 1095
 0.49
chr5_119951633_119951784 0.20 PRR16
 proline rich 16
 1075
 0.68
chrX_114468679_114469096 0.20 LRCH2
 leucine-rich repeats and calponin homology (CH) domain containing 2
 252
 0.93
chr18_70080364_70080515 0.20 CBLN2
 cerebellin 2 precursor
 130350
 0.06
chr18_28741984_28742214 0.20 DSC1
 desmocollin 1
 720
 0.67
chr9_33510457_33510690 0.19 RP11-255A11.2
4198
 0.19
chr11_120202601_120202952 0.19 ARHGEF12
 Rho guanine nucleotide exchange factor (GEF) 12
 5011
 0.19
chr7_1443631_1443991 0.19 MICALL2
 MICAL-like 2
 55151
 0.11
chr7_107808332_107808483 0.19 NRCAM
 neuronal cell adhesion molecule
 7395
 0.25
chr22_37957123_37957770 0.19 CDC42EP1
 CDC42 effector protein (Rho GTPase binding) 1
 959
 0.43
chr7_15597655_15597806 0.19 AGMO
 alkylglycerol monooxygenase
 3910
 0.36
chr1_117342787_117343202 0.18 CD2
 CD2 molecule
 45905
 0.14
chr15_48919611_48919986 0.18 FBN1
 fibrillin 1
 18120
 0.26
chr4_178167836_178167987 0.18 RP11-487E13.1
 Uncharacterized protein
 2016
 0.4
chr12_57522507_57523183 0.18 STAT6
 signal transducer and activator of transcription 6, interleukin-4 induced
 38
 0.64
chr4_154125931_154126175 0.18 TRIM2
 tripartite motif containing 2
 435
 0.87
chr11_125036127_125036278 0.18 PKNOX2
 PBX/knotted 1 homeobox 2
 1552
 0.29
chr14_55741621_55741910 0.18 FBXO34
 F-box protein 34
 2893
 0.32
chr8_62504364_62504526 0.18 ENSG00000222898
 .
 40126
 0.18
chr8_24799685_24800298 0.18 CTD-2168K21.2
14144
 0.18
chr3_74472777_74472928 0.18 CNTN3
 contactin 3 (plasmacytoma associated)
 97439
 0.09
chr12_28125138_28125289 0.18 PTHLH
 parathyroid hormone-like hormone
 297
 0.92
chr14_55035520_55036036 0.18 SAMD4A
 sterile alpha motif domain containing 4A
 1141
 0.56
chr2_8422146_8422297 0.18 AC011747.7
393675
 0.01
chr8_69242814_69243988 0.18 C8orf34
 chromosome 8 open reading frame 34
 56
 0.82
chr10_44139678_44139829 0.18 ZNF32-AS1
 ZNF32 antisense RNA 1
 433
 0.76
chr4_77704559_77704807 0.18 RP11-359D14.3
18434
 0.19
chr2_88499667_88499997 0.17 THNSL2
 threonine synthase-like 2 (S. cerevisiae)
 28853
 0.14
chr17_42293603_42293754 0.17 UBTF
 upstream binding transcription factor, RNA polymerase I
 2192
 0.13
chr1_42384263_42384523 0.17 HIVEP3
 human immunodeficiency virus type I enhancer binding protein 3
 15
 0.99
chr21_22573602_22573755 0.17 AP001136.2
25472
 0.24
chr9_8857014_8857547 0.17 PTPRD
 protein tyrosine phosphatase, receptor type, D
 496
 0.84
chr8_107738582_107738843 0.17 OXR1
 oxidation resistance 1
 299
 0.9
chr3_170148637_170148924 0.17 CLDN11
 claudin 11
 11925
 0.25
chr15_64635802_64635953 0.17 ENSG00000252774
 .
 1139
 0.39
chr17_48714816_48714967 0.17 ABCC3
 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
 2673
 0.17
chr11_18341339_18341613 0.17 HPS5
 Hermansky-Pudlak syndrome 5
 2245
 0.19
chr3_15351793_15351990 0.17 ENSG00000238891
 .
 6236
 0.16
chr17_1250998_1251685 0.17 YWHAE
 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
 13247
 0.18
chr9_130717953_130718104 0.17 FAM102A
 family with sequence similarity 102, member A
 5027
 0.11
chr8_41164878_41165029 0.17 SFRP1
 secreted frizzled-related protein 1
 444
 0.81
chr7_130680237_130680465 0.16 LINC-PINT
 long intergenic non-protein coding RNA, p53 induced transcript
 11483
 0.25
chr20_34743149_34743400 0.16 RP11-234K24.3
381
 0.62
chr6_155057921_155058172 0.16 SCAF8
 SR-related CTD-associated factor 8
 3496
 0.32
chr1_55701600_55701751 0.16 ENSG00000265822
 .
 10361
 0.22
chr2_189434243_189434394 0.16 GULP1
 GULP, engulfment adaptor PTB domain containing 1
 447
 0.91
chr14_68454519_68454814 0.16 CTD-2566J3.1
142247
 0.04
chr6_18043342_18043513 0.16 KIF13A
 kinesin family member 13A
 55573
 0.13
chr4_169616116_169616373 0.16 ENSG00000206613
 .
 8377
 0.21
chr8_79965001_79965152 0.16 ENSG00000264969
 .
 44522
 0.21
chr6_25193336_25193538 0.16 ENSG00000222373
 .
 796
 0.63
chr15_94473358_94473509 0.16 ENSG00000222409
 .
 33177
 0.25
chr5_40915264_40915466 0.15 ENSG00000253098
 .
 4135
 0.21
chr3_30722457_30722608 0.15 RP11-1024P17.1
16621
 0.27
chr20_38091019_38091170 0.15 ENSG00000241840
 .
 109692
 0.07
chr2_145594298_145594531 0.15 ZEB2
 zinc finger E-box binding homeobox 2
 315793
 0.01
chr4_138480079_138480230 0.15 PCDH18
 protocadherin 18
 26506
 0.28
chr3_43682701_43682852 0.15 ANO10
 anoctamin 10
 19216
 0.24
chr4_138454899_138455069 0.15 PCDH18
 protocadherin 18
 1336
 0.63
chr1_226919798_226919959 0.15 ITPKB
 inositol-trisphosphate 3-kinase B
 5281
 0.26
chr2_85515912_85516063 0.15 ENSG00000221579
 .
 10170
 0.13
chr22_26925865_26926016 0.15 TPST2
 tyrosylprotein sulfotransferase 2
 10897
 0.13
chr4_54564237_54564388 0.15 RP11-317M11.1
2244
 0.33
chr12_111905255_111905406 0.15 ATXN2
 ataxin 2
 3034
 0.24
chr18_496799_496950 0.15 COLEC12
 collectin sub-family member 12
 3848
 0.24
chr2_44397964_44398115 0.15 PPM1B
 protein phosphatase, Mg2+/Mn2+ dependent, 1B
 1990
 0.26
chr6_80656707_80657785 0.15 ELOVL4
 ELOVL fatty acid elongase 4
 51
 0.98
chr7_114649841_114649992 0.15 MDFIC
 MyoD family inhibitor domain containing
 75992
 0.12
chr18_2846122_2846273 0.15 EMILIN2
 elastin microfibril interfacer 2
 831
 0.57
chr17_762924_763100 0.15 NXN
 nucleoredoxin
 4325
 0.18
chr4_114677811_114678169 0.15 CAMK2D
 calcium/calmodulin-dependent protein kinase II delta
 4234
 0.36
chr21_32591500_32591929 0.15 TIAM1
 T-cell lymphoma invasion and metastasis 1
 57369
 0.16
chr7_17341776_17341927 0.15 AC003075.4
2870
 0.29
chr19_49521308_49522757 0.15 LHB
 luteinizing hormone beta polypeptide
 1694
 0.14
chr8_95448497_95449318 0.15 FSBP
 fibrinogen silencer binding protein
 263
 0.93
chr2_87811764_87811915 0.15 RP11-1399P15.1
34286
 0.22
chrX_24497462_24497656 0.15 PDK3
 pyruvate dehydrogenase kinase, isozyme 3
 13986
 0.21
chr13_60348574_60349034 0.14 DIAPH3-AS1
 DIAPH3 antisense RNA 1
 238081
 0.02
chr1_6521246_6521397 0.14 TNFRSF25
 tumor necrosis factor receptor superfamily, member 25
 4369
 0.12
chr6_46459858_46460009 0.14 RP11-795J1.1
144
 0.62
chr3_66502947_66503098 0.14 LRIG1
 leucine-rich repeats and immunoglobulin-like domains 1
 48334
 0.18
chr7_130663390_130663541 0.14 LINC-PINT
 long intergenic non-protein coding RNA, p53 induced transcript
 5403
 0.28
chrX_12029343_12029494 0.14 ENSG00000206792
 .
 43627
 0.19
chr2_201375425_201375576 0.14 KCTD18
 potassium channel tetramerization domain containing 18
 709
 0.45
chr6_72103286_72103437 0.14 ENSG00000207827
 .
 9963
 0.21
chr16_23144177_23144367 0.14 USP31
 ubiquitin specific peptidase 31
 16319
 0.22
chr5_52206164_52206315 0.14 ITGA2
 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
 78917
 0.09
chr13_63982821_63982972 0.14 LINC00395
 long intergenic non-protein coding RNA 395
 308255
 0.01
chr3_175244326_175245006 0.14 ENSG00000201648
 .
 82601
 0.1
chr4_148602160_148602311 0.14 PRMT10
 protein arginine methyltransferase 10 (putative)
 3041
 0.27
chrX_20157621_20157927 0.14 EIF1AX-AS1
 EIF1AX antisense RNA 1
 312
 0.82
chr7_104660604_104660779 0.14 KMT2E
 lysine (K)-specific methyltransferase 2E
 5783
 0.17
chr15_92499471_92499678 0.14 SLCO3A1
 solute carrier organic anion transporter family, member 3A1
 102223
 0.08
chr11_43665243_43665394 0.14 HSD17B12
 hydroxysteroid (17-beta) dehydrogenase 12
 36941
 0.17
chr9_82427303_82427454 0.14 TLE4
 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
 105697
 0.08
chr5_172306134_172306575 0.13 ERGIC1
 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
 25866
 0.16
chr14_61224053_61224421 0.13 MNAT1
 MNAT CDK-activating kinase assembly factor 1
 22743
 0.2
chr17_61353070_61353290 0.13 RP11-269G24.2
37702
 0.15
chr5_77843393_77843700 0.13 LHFPL2
 lipoma HMGIC fusion partner-like 2
 1428
 0.58
chr11_118504420_118504703 0.13 AP002954.3
2777
 0.17
chr7_111201271_111201551 0.13 IMMP2L
 IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
 569
 0.87
chr9_3794388_3794539 0.13 RP11-252M18.3
81121
 0.11
chr2_144006322_144006473 0.13 RP11-190J23.1
76656
 0.11
chr11_14995465_14995616 0.13 CALCA
 calcitonin-related polypeptide alpha
 1640
 0.48
chr4_143481342_143481493 0.13 INPP4B
 inositol polyphosphate-4-phosphatase, type II, 105kDa
 405
 0.92
chr8_131257957_131258144 0.13 ASAP1
 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
 1238
 0.6
chr8_131577804_131578063 0.13 ASAP1
 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
 122027
 0.06
chr9_95610203_95610354 0.13 ZNF484
 zinc finger protein 484
 8322
 0.17
chr1_23523630_23523879 0.13 HTR1D
 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
 2532
 0.23
chr1_8686332_8686483 0.13 RERE
 arginine-glutamic acid dipeptide (RE) repeats
 1968
 0.44
chr5_15533409_15533775 0.13 FBXL7
 F-box and leucine-rich repeat protein 7
 32045
 0.23
chr4_20289069_20289220 0.13 SLIT2
 slit homolog 2 (Drosophila)
 32601
 0.24
chr3_116164058_116164214 0.13 LSAMP
 limbic system-associated membrane protein
 242
 0.96
chr2_181995547_181995698 0.13 UBE2E3
 ubiquitin-conjugating enzyme E2E 3
 148872
 0.04
chr6_132721617_132721768 0.13 MOXD1
 monooxygenase, DBH-like 1
 922
 0.69
chr8_99952075_99952653 0.13 STK3
 serine/threonine kinase 3
 2435
 0.25
chr3_168744118_168744269 0.13 MECOM
 MDS1 and EVI1 complex locus
 101629
 0.08
chr10_35079377_35079528 0.13 PARD3
 par-3 family cell polarity regulator
 24797
 0.2
chr4_57156140_57156443 0.13 ENSG00000252489
 .
 1541
 0.39
chr5_35855125_35855276 0.12 IL7R
 interleukin 7 receptor
 1197
 0.5
chr6_160509984_160510135 0.12 IGF2R
 insulin-like growth factor 2 receptor
 3966
 0.27
chr19_4473895_4474732 0.12 HDGFRP2
 Hepatoma-derived growth factor-related protein 2
 576
 0.53
chr1_61598053_61598265 0.12 RP4-802A10.1
7754
 0.25
chr7_80543186_80543337 0.12 SEMA3C
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
 5238
 0.35
chr3_12925603_12925754 0.12 AC034198.7
33520
 0.13
chr5_16827159_16827310 0.12 ENSG00000253093
 .
 26869
 0.22
chr12_70937490_70937641 0.12 RP11-588H23.3
23579
 0.22
chr1_103573283_103573505 0.12 COL11A1
 collagen, type XI, alpha 1
 340
 0.94
chr4_41122983_41123211 0.12 ENSG00000207198
 .
 7138
 0.23
chr14_91525121_91525272 0.12 RPS6KA5
 ribosomal protein S6 kinase, 90kDa, polypeptide 5
 1282
 0.35
chr2_115419198_115419381 0.12 DPP10-AS3
 DPP10 antisense RNA 3
 171836
 0.03
chr4_90056009_90056160 0.12 ENSG00000212226
 .
 4081
 0.27
chr22_36232996_36233711 0.12 RBFOX2
 RNA binding protein, fox-1 homolog (C. elegans) 2
 2912
 0.37
chr2_145261378_145261529 0.12 ZEB2
 zinc finger E-box binding homeobox 2
 13662
 0.24
chr5_112481657_112481808 0.12 MCC
 mutated in colorectal cancers
 88642
 0.09
chr6_108108889_108109040 0.12 SCML4
 sex comb on midleg-like 4 (Drosophila)
 15509
 0.27
chr1_193509624_193509775 0.12 ENSG00000252241
 .
 191375
 0.03
chr21_36359858_36360101 0.12 RUNX1
 runt-related transcription factor 1
 61483
 0.16
chr2_112195991_112196142 0.12 ENSG00000266139
 .
 117398
 0.07
chr7_137638804_137638955 0.12 AC022173.2
785
 0.68
chr13_41487964_41488115 0.12 SUGT1P3
 SUGT1 pseudogene 3
 7808
 0.19
chr20_22756193_22756438 0.12 ENSG00000265151
 .
 42376
 0.2
chr9_123693983_123694176 0.12 TRAF1
 TNF receptor-associated factor 1
 2628
 0.31
chr3_8493679_8493830 0.12 LMCD1-AS1
 LMCD1 antisense RNA 1 (head to head)
 49530
 0.14
chr7_25431142_25431293 0.12 ENSG00000202233
 .
 126942
 0.05
chr6_73456305_73456456 0.12 KCNQ5-IT1
 KCNQ5 intronic transcript 1 (non-protein coding)
 116157
 0.06
chr6_27440042_27440937 0.12 ZNF184
 zinc finger protein 184
 29
 0.98
chr12_78836151_78836302 0.12 NAV3
 neuron navigator 3
 243370
 0.02
chr11_86085513_86085741 0.12 CCDC81
 coiled-coil domain containing 81
 151
 0.96
chr3_87487041_87487197 0.12 POU1F1
 POU class 1 homeobox 1
 161382
 0.04
chr13_52217695_52217893 0.12 ENSG00000242893
 .
 49443
 0.11
chr18_66506011_66506162 0.12 CCDC102B
 coiled-coil domain containing 102B
 2085
 0.36

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of DMC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0071504 cellular response to heparin(GO:0071504)
0.1 0.2 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.0 0.2 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.0 0.0 GO:0002890 negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0 0.1 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367)
0.0 0.1 GO:0002072 optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0 0.1 GO:0003078 obsolete regulation of natriuresis(GO:0003078)
0.0 0.1 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.1 GO:0048289 isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0 0.1 GO:1900115 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.1 GO:0097531 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.1 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.1 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.1 GO:0048669 collateral sprouting in absence of injury(GO:0048669)
0.0 0.1 GO:0032730 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730)
0.0 0.0 GO:0060510 lung saccule development(GO:0060430) Type II pneumocyte differentiation(GO:0060510)
0.0 0.2 GO:0010324 phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0 0.1 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.1 GO:0008356 asymmetric cell division(GO:0008356)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.0 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0031579 membrane raft organization(GO:0031579)
0.0 0.0 GO:0002326 B cell lineage commitment(GO:0002326)
0.0 0.1 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0 0.1 GO:0060638 mesenchymal-epithelial cell signaling(GO:0060638)
0.0 0.0 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.0 0.1 GO:0010875 positive regulation of cholesterol efflux(GO:0010875)
0.0 0.1 GO:0071318 cellular response to ATP(GO:0071318)
0.0 0.1 GO:2000400 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0 0.1 GO:0002837 regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839)
0.0 0.1 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0 0.0 GO:0061299 retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.0 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.0 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.0 0.0 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.0 GO:0010842 retina layer formation(GO:0010842)
0.0 0.0 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.1 GO:0090598 male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0 0.1 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.0 GO:0060900 embryonic camera-type eye formation(GO:0060900)
0.0 0.0 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.0 0.0 GO:0036037 CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.0 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0 0.1 GO:0031274 pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.0 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.0 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.1 GO:0016246 RNA interference(GO:0016246)
0.0 0.0 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 0.0 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.0 0.0 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.0 0.0 GO:0044413 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.1 GO:0042640 anagen(GO:0042640)
0.0 0.0 GO:0043578 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.0 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.0 GO:0072191 positive regulation of smooth muscle cell differentiation(GO:0051152) ureter smooth muscle development(GO:0072191) ureter smooth muscle cell differentiation(GO:0072193)
0.0 0.0 GO:0060594 mammary gland specification(GO:0060594)
0.0 0.2 GO:0002675 positive regulation of acute inflammatory response(GO:0002675)
0.0 0.0 GO:0048087 positive regulation of developmental pigmentation(GO:0048087)
0.0 0.0 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.0 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)
0.0 0.1 GO:0009103 lipopolysaccharide biosynthetic process(GO:0009103)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.3 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.1 GO:0043260 laminin-11 complex(GO:0043260)
0.0 0.1 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.2 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.0 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.0 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.0 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.0 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.1 0.3 GO:0009374 biotin binding(GO:0009374)
0.0 0.1 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.0 0.1 GO:0097493 extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0 0.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.1 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0 0.1 GO:0034187 obsolete apolipoprotein E binding(GO:0034187)
0.0 0.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0 0.1 GO:0016595 glutamate binding(GO:0016595)
0.0 0.1 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0043175 RNA polymerase core enzyme binding(GO:0043175)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.1 GO:0030172 troponin C binding(GO:0030172)
0.0 0.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.1 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.0 GO:0048039 ubiquinone binding(GO:0048039)
0.0 0.1 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.1 GO:0005534 galactose binding(GO:0005534)
0.0 0.0 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.0 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.0 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.0 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.0 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.1 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.0 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.0 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.0 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 PID SHP2 PATHWAY SHP2 signaling
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.2 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.0 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.0 0.1 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo