Project
ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for DPRX

Z-value: 1.13

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Transcription factors associated with DPRX

Gene Symbol Gene ID Gene Info
DPRX
ENSG00000204595.1 DPRX

Activity of the DPRX motif across conditions

Conditions sorted by the z-value of the DPRX motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr9_73483972_73484180 0.54 TRPM3
 transient receptor potential cation channel, subfamily M, member 3
 102
 0.98
chr6_86163029_86163180 0.52 NT5E
 5'-nucleotidase, ecto (CD73)
 3277
 0.35
chr8_49831086_49831370 0.48 SNAI2
 snail family zinc finger 2
 2760
 0.41
chr19_44860491_44860902 0.47 ZNF112
 zinc finger protein 112
 130
 0.96
chr12_47358473_47358699 0.46 PCED1B
 PC-esterase domain containing 1B
 114800
 0.06
chr3_66139685_66140118 0.45 SLC25A26
 solute carrier family 25 (S-adenosylmethionine carrier), member 26
 20616
 0.25
chr1_163040363_163040678 0.42 RGS4
 regulator of G-protein signaling 4
 1314
 0.56
chr1_170632786_170633084 0.41 PRRX1
 paired related homeobox 1
 112
 0.98
chr10_97049818_97050125 0.41 PDLIM1
 PDZ and LIM domain 1
 810
 0.7
chrX_45634801_45635003 0.41 ENSG00000207725
 .
 28372
 0.2
chr9_13278507_13279169 0.39 RP11-272P10.2
348
 0.67
chr5_54456050_54456451 0.39 GPX8
 glutathione peroxidase 8 (putative)
 252
 0.86
chr4_41157110_41157449 0.39 ENSG00000207198
 .
 41320
 0.14
chr8_55294582_55295235 0.38 ENSG00000244107
 .
 38120
 0.17
chr3_100711062_100711329 0.38 ABI3BP
 ABI family, member 3 (NESH) binding protein
 1102
 0.61
chr22_31198410_31198813 0.38 OSBP2
 oxysterol binding protein 2
 462
 0.84
chr6_72178498_72178870 0.37 ENSG00000207827
 .
 65360
 0.11
chr12_12972772_12973017 0.37 DDX47
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
 6600
 0.18
chr7_90012947_90013805 0.36 CLDN12
 claudin 12
 341
 0.9
chr13_73715664_73715973 0.36 ENSG00000265959
 .
 16871
 0.19
chr11_66083364_66083632 0.35 CD248
 CD248 molecule, endosialin
 1017
 0.24
chr15_59663421_59663716 0.34 FAM81A
 family with sequence similarity 81, member A
 1324
 0.28
chr3_150088154_150088521 0.34 TSC22D2
 TSC22 domain family, member 2
 37785
 0.2
chr4_148693225_148693748 0.33 ENSG00000264274
 .
 10260
 0.18
chr13_40175117_40175459 0.33 LHFP
 lipoma HMGIC fusion partner
 2020
 0.37
chr9_14251628_14251810 0.33 NFIB
 nuclear factor I/B
 56293
 0.15
chr5_35851300_35851523 0.33 IL7R
 interleukin 7 receptor
 1386
 0.45
chr15_23931247_23932124 0.33 NDN
 necdin, melanoma antigen (MAGE) family member
 765
 0.7
chr2_134325508_134325697 0.33 NCKAP5
 NCK-associated protein 5
 429
 0.88
chr3_173302379_173302636 0.33 NLGN1
 neuroligin 1
 162
 0.98
chr6_116833589_116833880 0.33 TRAPPC3L
 trafficking protein particle complex 3-like
 228
 0.83
chr15_96868857_96869008 0.33 NR2F2
 nuclear receptor subfamily 2, group F, member 2
 235
 0.88
chr6_26424520_26424724 0.32 BTN2A3P
 butyrophilin, subfamily 2, member A3, pseudogene
 2275
 0.18
chr1_82266791_82267081 0.32 LPHN2
 latrophilin 2
 854
 0.76
chr6_5498160_5498518 0.32 RP1-232P20.1
40031
 0.2
chr12_66122461_66123138 0.32 HMGA2
 high mobility group AT-hook 2
 95112
 0.08
chr3_128207705_128209147 0.32 RP11-475N22.4
326
 0.79
chr8_57360709_57360896 0.31 PENK
 proenkephalin
 1509
 0.41
chr14_69015254_69015531 0.31 CTD-2325P2.4
79770
 0.1
chr10_4284322_4284712 0.31 ENSG00000207124
 .
 272627
 0.02
chr2_217180593_217180957 0.31 AC069155.1
12727
 0.18
chr3_192126971_192127690 0.31 FGF12
 fibroblast growth factor 12
 492
 0.87
chr1_170630999_170631537 0.30 PRRX1
 paired related homeobox 1
 1007
 0.68
chrX_135231057_135231247 0.30 FHL1
 four and a half LIM domains 1
 415
 0.86
chr10_60275835_60276146 0.30 BICC1
 bicaudal C homolog 1 (Drosophila)
 3090
 0.38
chr1_7812599_7812750 0.30 CAMTA1
 calmodulin binding transcription activator 1
 7653
 0.17
chr1_61668583_61669016 0.30 RP4-802A10.1
78394
 0.11
chr15_39874864_39875069 0.30 THBS1
 thrombospondin 1
 1672
 0.37
chr10_92680755_92680938 0.30 ANKRD1
 ankyrin repeat domain 1 (cardiac muscle)
 187
 0.93
chr2_237654651_237654995 0.29 ACKR3
 atypical chemokine receptor 3
 176539
 0.03
chr5_125475529_125475786 0.29 ENSG00000265637
 .
 56871
 0.17
chr4_41215270_41215769 0.29 APBB2
 amyloid beta (A4) precursor protein-binding, family B, member 2
 956
 0.59
chr7_116141197_116141631 0.29 CAV2
 caveolin 2
 1580
 0.29
chr19_48101898_48102049 0.29 GLTSCR1
 glioma tumor suppressor candidate region gene 1
 9480
 0.14
chr4_154125621_154125824 0.29 TRIM2
 tripartite motif containing 2
 104
 0.98
chr13_30276703_30277107 0.29 SLC7A1
 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
 107080
 0.07
chr7_134464463_134465343 0.28 CALD1
 caldesmon 1
 474
 0.89
chr20_14317138_14317687 0.28 FLRT3
 fibronectin leucine rich transmembrane protein 3
 842
 0.69
chr7_82071322_82071473 0.28 CACNA2D1
 calcium channel, voltage-dependent, alpha 2/delta subunit 1
 1634
 0.55
chr6_128812548_128813040 0.28 RP1-86D1.5
8878
 0.17
chr13_102572043_102572458 0.27 FGF14
 fibroblast growth factor 14
 3255
 0.32
chr1_16085392_16086186 0.27 FBLIM1
 filamin binding LIM protein 1
 497
 0.68
chr13_38171648_38172094 0.27 POSTN
 periostin, osteoblast specific factor
 992
 0.71
chr7_28944342_28944522 0.27 CTB-113D17.1
75151
 0.1
chr10_30842846_30843212 0.27 ENSG00000239744
 .
 1804
 0.44
chr17_12877545_12877942 0.27 ENSG00000266152
 .
 1601
 0.34
chr17_39205284_39205523 0.26 KRTAP2-1
 keratin associated protein 2-1
 1835
 0.12
chr18_65983753_65984295 0.26 TMX3
 thioredoxin-related transmembrane protein 3
 398270
 0.01
chr3_87040086_87040946 0.26 VGLL3
 vestigial like 3 (Drosophila)
 247
 0.96
chr10_3929254_3929732 0.26 KLF6
 Kruppel-like factor 6
 102020
 0.08
chrX_114796559_114796881 0.26 RP1-93I3.1
314
 0.83
chr3_100730225_100730376 0.26 ABI3BP
 ABI family, member 3 (NESH) binding protein
 17941
 0.25
chr10_112258642_112259418 0.26 DUSP5
 dual specificity phosphatase 5
 1434
 0.41
chr11_35585007_35585160 0.26 PAMR1
 peptidase domain containing associated with muscle regeneration 1
 33235
 0.18
chr4_55098050_55098472 0.26 PDGFRA
 platelet-derived growth factor receptor, alpha polypeptide
 1772
 0.47
chr4_81230543_81230858 0.26 C4orf22
 chromosome 4 open reading frame 22
 26174
 0.21
chr11_69458516_69459047 0.25 CCND1
 cyclin D1
 2807
 0.29
chr4_126243331_126243824 0.25 FAT4
 FAT atypical cadherin 4
 6023
 0.3
chr15_89914451_89914936 0.25 ENSG00000207819
 .
 3445
 0.23
chr15_48937037_48938293 0.25 FBN1
 fibrillin 1
 253
 0.95
chr1_67446927_67447083 0.25 MIER1
 mesoderm induction early response 1, transcriptional regulator
 51079
 0.12
chr21_30673835_30674113 0.25 BACH1
 BTB and CNC homology 1, basic leucine zipper transcription factor 1
 851
 0.62
chr15_96878987_96879612 0.25 ENSG00000222651
 .
 2809
 0.21
chr16_4162280_4162503 0.25 ADCY9
 adenylate cyclase 9
 1636
 0.44
chr2_206540536_206540687 0.25 NRP2
 neuropilin 2
 6613
 0.3
chr10_116444886_116445037 0.25 ABLIM1
 actin binding LIM protein 1
 547
 0.83
chr1_215181525_215181703 0.25 KCNK2
 potassium channel, subfamily K, member 2
 2416
 0.46
chr12_88972313_88972545 0.25 KITLG
 KIT ligand
 1809
 0.39
chr12_91570586_91570804 0.25 DCN
 decorin
 1634
 0.5
chr8_97172057_97172969 0.25 GDF6
 growth differentiation factor 6
 507
 0.84
chr17_77019963_77021139 0.25 C1QTNF1
 C1q and tumor necrosis factor related protein 1
 208
 0.91
chr2_213641909_213642154 0.24 ENSG00000221388
 .
 13632
 0.3
chr1_215697066_215697229 0.24 KCTD3
 potassium channel tetramerization domain containing 3
 43588
 0.2
chr22_39801646_39801840 0.24 TAB1
 TGF-beta activated kinase 1/MAP3K7 binding protein 1
 5954
 0.16
chr3_114477226_114477377 0.24 ZBTB20
 zinc finger and BTB domain containing 20
 486
 0.86
chr9_4838369_4838520 0.24 RCL1
 RNA terminal phosphate cyclase-like 1
 1074
 0.46
chr6_84418004_84418417 0.24 SNAP91
 synaptosomal-associated protein, 91kDa
 77
 0.99
chr10_118764443_118765166 0.23 KIAA1598
 KIAA1598
 72
 0.98
chr7_18548938_18549201 0.23 HDAC9
 histone deacetylase 9
 133
 0.98
chr5_59040900_59041158 0.23 PDE4D
 phosphodiesterase 4D, cAMP-specific
 23433
 0.24
chr20_8627018_8627192 0.23 ENSG00000222298
 .
 36218
 0.18
chr4_4494063_4494282 0.23 STX18-IT1
 STX18 intronic transcript 1 (non-protein coding)
 10745
 0.21
chr2_230131761_230131912 0.23 PID1
 phosphotyrosine interaction domain containing 1
 4145
 0.31
chr12_72667295_72667865 0.23 TRHDE
 thyrotropin-releasing hormone degrading enzyme
 317
 0.85
chr9_131684300_131684733 0.23 PHYHD1
 phytanoyl-CoA dioxygenase domain containing 1
 46
 0.96
chr6_84418438_84418730 0.23 SNAP91
 synaptosomal-associated protein, 91kDa
 147
 0.98
chr8_29664962_29665155 0.23 ENSG00000221003
 .
 121063
 0.06
chr16_86619409_86619937 0.23 FOXL1
 forkhead box L1
 7558
 0.18
chr11_108542944_108543195 0.23 DDX10
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
 7220
 0.29
chr7_94536809_94537187 0.23 PPP1R9A
 protein phosphatase 1, regulatory subunit 9A
 11
 0.99
chr9_21558261_21558438 0.23 MIR31HG
 MIR31 host gene (non-protein coding)
 1319
 0.44
chrX_19688369_19688923 0.23 SH3KBP1
 SH3-domain kinase binding protein 1
 166
 0.97
chr1_245951382_245951568 0.23 RP11-522M21.3
111695
 0.07
chr2_199236865_199237052 0.22 ENSG00000252511
 .
 194495
 0.03
chr17_762649_762818 0.22 NXN
 nucleoredoxin
 4604
 0.18
chr1_119543090_119543475 0.22 TBX15
 T-box 15
 11103
 0.25
chr1_98499845_98500395 0.22 ENSG00000225206
 .
 10787
 0.31
chr4_128703513_128704516 0.22 HSPA4L
 heat shock 70kDa protein 4-like
 537
 0.81
chr2_218807657_218808117 0.22 TNS1
 tensin 1
 906
 0.64
chr17_17851472_17851637 0.22 TOM1L2
 target of myb1-like 2 (chicken)
 24157
 0.14
chr16_640288_641115 0.22 RAB40C
 RAB40C, member RAS oncogene family
 369
 0.68
chr18_9416679_9416911 0.22 RALBP1
 ralA binding protein 1
 58212
 0.1
chr13_37492943_37493377 0.22 SMAD9
 SMAD family member 9
 1215
 0.52
chr1_57111479_57111630 0.22 PRKAA2
 protein kinase, AMP-activated, alpha 2 catalytic subunit
 559
 0.84
chr10_23092690_23092841 0.22 ENSG00000206842
 .
 16443
 0.26
chr3_62360137_62360326 0.22 FEZF2
 FEZ family zinc finger 2
 232
 0.94
chr13_45147711_45147927 0.22 TSC22D1
 TSC22 domain family, member 1
 2573
 0.38
chr15_99664067_99664316 0.22 RP11-6O2.4
7820
 0.14
chr21_31599857_31600016 0.21 CLDN8
 claudin 8
 11545
 0.17
chr8_87052179_87052395 0.21 PSKH2
 protein serine kinase H2
 29639
 0.19
chr1_231964431_231964582 0.21 DISC1-IT1
 DISC1 intronic transcript 1 (non-protein coding)
 97074
 0.08
chr2_236514053_236514361 0.21 ENSG00000221704
 .
 33632
 0.2
chr6_42283591_42283839 0.21 ENSG00000221252
 .
 96419
 0.06
chr21_28335011_28335184 0.21 ADAMTS5
 ADAM metallopeptidase with thrombospondin type 1 motif, 5
 3735
 0.27
chr7_92264053_92264321 0.21 FAM133B
 family with sequence similarity 133, member B
 44479
 0.15
chr14_101034010_101035263 0.21 BEGAIN
 brain-enriched guanylate kinase-associated
 192
 0.93
chr5_107040810_107041069 0.21 ENSG00000239708
 .
 29828
 0.21
chr17_60868253_60868692 0.21 MARCH10
 membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
 15529
 0.23
chr10_114552786_114553214 0.21 RP11-57H14.4
30249
 0.21
chr6_85484117_85484534 0.21 TBX18
 T-box 18
 10088
 0.3
chr7_84440948_84441099 0.21 ENSG00000265050
 .
 145699
 0.05
chr1_212841074_212841261 0.21 ENSG00000207491
 .
 24439
 0.13
chr5_71403169_71403320 0.21 MAP1B
 microtubule-associated protein 1B
 69
 0.98
chr4_138045655_138046009 0.21 ENSG00000222526
 .
 103450
 0.09
chr5_111165128_111165279 0.21 NREP
 neuronal regeneration related protein
 71288
 0.1
chr12_101188772_101189038 0.21 ANO4
 anoctamin 4
 169
 0.97
chr12_42876039_42876190 0.21 PRICKLE1
 prickle homolog 1 (Drosophila)
 760
 0.61
chr6_3844247_3844398 0.21 FAM50B
 family with sequence similarity 50, member B
 5298
 0.22
chr5_167000298_167000463 0.21 CTB-78F1.1
87106
 0.09
chr1_161931679_161931926 0.20 OLFML2B
 olfactomedin-like 2B
 23220
 0.22
chr16_54209442_54209593 0.20 RP11-324D17.1
 HCG2045435; Uncharacterized protein
 71360
 0.11
chr16_54321004_54321411 0.20 IRX3
 iroquois homeobox 3
 532
 0.83
chr3_25472946_25473178 0.20 RARB
 retinoic acid receptor, beta
 3260
 0.35
chr6_10415043_10415268 0.20 TFAP2A
 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
 63
 0.82
chr7_51101841_51102176 0.20 RP4-724E13.2
16848
 0.28
chr4_169643911_169644062 0.20 PALLD
 palladin, cytoskeletal associated protein
 10676
 0.22
chr9_79450389_79450574 0.20 PRUNE2
 prune homolog 2 (Drosophila)
 70520
 0.11
chr6_72892116_72892352 0.20 RIMS1
 regulating synaptic membrane exocytosis 1
 221
 0.96
chr5_123036641_123036976 0.20 CSNK1G3
 casein kinase 1, gamma 3
 112689
 0.07
chr5_77584190_77584360 0.20 AP3B1
 adaptor-related protein complex 3, beta 1 subunit
 6241
 0.22
chr1_23066485_23066803 0.20 ENSG00000216157
 .
 8760
 0.17
chr1_185373783_185374254 0.20 ENSG00000252407
 .
 29358
 0.21
chr3_58810226_58810377 0.20 RP11-147N17.1
104
 0.98
chr10_69866394_69866619 0.20 MYPN
 myopalladin
 594
 0.76
chr6_1614659_1614953 0.20 FOXC1
 forkhead box C1
 4125
 0.35
chr16_72570565_72570716 0.20 ENSG00000221286
 .
 42896
 0.18
chr2_239792608_239792759 0.20 TWIST2
 twist family bHLH transcription factor 2
 36010
 0.18
chr8_65488422_65488732 0.20 RP11-21C4.1
1243
 0.52
chr6_151648743_151648894 0.20 AKAP12
 A kinase (PRKA) anchor protein 12
 1995
 0.23
chr10_17391082_17391289 0.20 ST8SIA6
 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
 22077
 0.18
chr7_127911991_127912224 0.20 ENSG00000221429
 .
 17950
 0.16
chr20_10720180_10720390 0.20 JAG1
 jagged 1
 65591
 0.13
chr2_227661871_227662069 0.20 IRS1
 insulin receptor substrate 1
 2505
 0.3
chr4_134068181_134068851 0.20 PCDH10
 protocadherin 10
 1954
 0.52
chr19_1361236_1361464 0.19 MUM1
 melanoma associated antigen (mutated) 1
 4987
 0.1
chr2_172388580_172388749 0.19 CYBRD1
 cytochrome b reductase 1
 9075
 0.25
chr3_190812364_190812515 0.19 OSTN
 osteocrin
 104591
 0.07
chr22_36841557_36841862 0.19 ENSG00000252225
 .
 4694
 0.17
chr12_91503113_91503264 0.19 LUM
 lumican
 2420
 0.34
chr3_159898355_159898715 0.19 IL12A-AS1
 IL12A antisense RNA 1
 26344
 0.17
chr5_127981136_127981287 0.19 FBN2
 fibrillin 2
 13667
 0.23
chr1_172558158_172558450 0.19 ENSG00000251943
 .
 24370
 0.2
chr10_114819686_114819837 0.19 TCF7L2
 transcription factor 7-like 2 (T-cell specific, HMG-box)
 83918
 0.1
chr5_111890138_111890295 0.19 EPB41L4A-AS2
 EPB41L4A antisense RNA 2 (head to head)
 134936
 0.05
chr3_30852868_30853019 0.19 GADL1
 glutamate decarboxylase-like 1
 83210
 0.1
chr6_56405735_56406219 0.19 DST
 dystonin
 67189
 0.13
chr20_10562988_10563139 0.19 JAG1
 jagged 1
 80091
 0.1
chr14_52122113_52122363 0.19 FRMD6
 FERM domain containing 6
 3540
 0.25
chr12_41091641_41091792 0.19 CNTN1
 contactin 1
 5362
 0.33
chr5_78365996_78366206 0.19 BHMT2
 betaine--homocysteine S-methyltransferase 2
 511
 0.53
chr10_98750971_98751122 0.19 RP11-175O19.4
1161
 0.5
chr3_101547890_101548066 0.19 NFKBIZ
 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
 1141
 0.47
chr12_109227226_109227475 0.19 ENSG00000207622
 .
 3432
 0.19
chr4_153272243_153272573 0.19 FBXW7
 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
 1715
 0.41
chr9_34651822_34652525 0.19 IL11RA
 interleukin 11 receptor, alpha
 16
 0.94
chr1_162665785_162665936 0.19 DDR2
 discoidin domain receptor tyrosine kinase 2
 63600
 0.1
chr12_32655077_32655322 0.19 FGD4
 FYVE, RhoGEF and PH domain containing 4
 48
 0.98
chr20_22756193_22756438 0.19 ENSG00000265151
 .
 42376
 0.2
chr10_74878153_74878313 0.19 RP11-152N13.16
6930
 0.1
chr9_22008460_22008654 0.19 CDKN2B
 cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
 395
 0.82

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of DPRX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.1 0.4 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.1 0.4 GO:0035583 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1 0.3 GO:0050923 regulation of negative chemotaxis(GO:0050923)
0.1 0.4 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 0.3 GO:0033025 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.1 1.3 GO:0042474 middle ear morphogenesis(GO:0042474)
0.1 0.4 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.1 0.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.2 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.1 0.4 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.1 0.2 GO:0010842 retina layer formation(GO:0010842)
0.1 0.2 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.1 0.1 GO:0010996 response to auditory stimulus(GO:0010996) auditory behavior(GO:0031223)
0.1 0.5 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.1 0.2 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 0.2 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.1 0.2 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.1 0.2 GO:0072268 pattern specification involved in metanephros development(GO:0072268)
0.1 0.2 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.1 0.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 0.1 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.1 0.2 GO:0048875 surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.1 0.2 GO:0043589 skin morphogenesis(GO:0043589)
0.1 0.2 GO:0032808 lacrimal gland development(GO:0032808)
0.1 0.4 GO:0033327 Leydig cell differentiation(GO:0033327)
0.1 0.2 GO:0055022 negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.1 0.2 GO:0045077 negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.1 0.2 GO:0060737 prostate gland morphogenetic growth(GO:0060737)
0.0 0.1 GO:0030540 female genitalia development(GO:0030540)
0.0 0.1 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.1 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.0 0.1 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.0 0.2 GO:0008218 bioluminescence(GO:0008218)
0.0 0.1 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.1 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.1 GO:0051938 L-glutamate import(GO:0051938)
0.0 0.1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.4 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.1 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.1 GO:0001880 Mullerian duct regression(GO:0001880)
0.0 0.3 GO:0007413 axonal fasciculation(GO:0007413)
0.0 0.2 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 0.1 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.1 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.0 0.1 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367)
0.0 0.1 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.0 0.1 GO:0002689 negative regulation of leukocyte chemotaxis(GO:0002689)
0.0 0.2 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.2 GO:0002076 osteoblast development(GO:0002076)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0045916 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0 0.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.1 GO:0010107 potassium ion import(GO:0010107)
0.0 0.1 GO:0014820 tonic smooth muscle contraction(GO:0014820) artery smooth muscle contraction(GO:0014824)
0.0 0.0 GO:0060913 cardiac cell fate determination(GO:0060913)
0.0 0.1 GO:0070141 response to UV-A(GO:0070141)
0.0 0.2 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
0.0 0.1 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.0 0.1 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.0 0.1 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.1 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.0 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.1 GO:0032347 regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0 0.1 GO:0090081 regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081)
0.0 0.1 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.1 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.1 GO:0060363 cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0 0.0 GO:0060437 lung growth(GO:0060437)
0.0 0.1 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.0 0.2 GO:0043537 negative regulation of blood vessel endothelial cell migration(GO:0043537)
0.0 0.1 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.2 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 0.1 GO:0006533 aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.0 0.1 GO:0032236 obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0 0.7 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.1 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.0 0.1 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.0 0.0 GO:0060197 cloaca development(GO:0035844) cloacal septation(GO:0060197)
0.0 0.0 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.1 GO:0034653 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0 0.1 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0003099 positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.0 0.3 GO:0007184 SMAD protein import into nucleus(GO:0007184)
0.0 0.0 GO:0060449 bud elongation involved in lung branching(GO:0060449)
0.0 0.1 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.1 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.1 GO:0014850 response to muscle activity(GO:0014850)
0.0 0.1 GO:0008614 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0 0.2 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.0 GO:0048520 positive regulation of behavior(GO:0048520)
0.0 0.1 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0060992 response to fungicide(GO:0060992)
0.0 0.6 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.1 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0 0.0 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.0 0.1 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.0 GO:0003148 outflow tract septum morphogenesis(GO:0003148)
0.0 0.1 GO:0060042 retina morphogenesis in camera-type eye(GO:0060042)
0.0 0.1 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.0 GO:0045992 negative regulation of embryonic development(GO:0045992)
0.0 0.1 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.1 GO:0060997 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0 0.3 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.2 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.0 0.0 GO:0002072 optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0 0.1 GO:1904748 regulation of apoptotic process involved in morphogenesis(GO:1902337) regulation of apoptotic process involved in development(GO:1904748)
0.0 0.1 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0071436 sodium ion export(GO:0071436)
0.0 0.5 GO:1901800 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 0.0 GO:0060242 contact inhibition(GO:0060242)
0.0 0.1 GO:0045103 intermediate filament-based process(GO:0045103)
0.0 0.1 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 0.1 GO:0072205 metanephric collecting duct development(GO:0072205)
0.0 0.2 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.4 GO:0048010 vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.0 0.1 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.0 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.0 GO:0072033 renal vesicle formation(GO:0072033)
0.0 0.2 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.3 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.1 GO:0003214 cardiac left ventricle morphogenesis(GO:0003214)
0.0 0.0 GO:0042249 establishment of planar polarity of embryonic epithelium(GO:0042249)
0.0 0.4 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.1 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.1 GO:0051927 obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051927)
0.0 0.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.0 GO:0071379 cellular response to prostaglandin stimulus(GO:0071379)
0.0 0.2 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 0.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.2 GO:0032330 regulation of chondrocyte differentiation(GO:0032330)
0.0 0.1 GO:0016264 gap junction assembly(GO:0016264)
0.0 0.1 GO:0007412 axon target recognition(GO:0007412)
0.0 0.1 GO:0008228 opsonization(GO:0008228)
0.0 0.1 GO:0021800 cerebral cortex tangential migration(GO:0021800)
0.0 0.0 GO:0051284 negative regulation of ion transmembrane transporter activity(GO:0032413) negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0 0.1 GO:0007494 midgut development(GO:0007494)
0.0 0.1 GO:0021955 central nervous system neuron axonogenesis(GO:0021955)
0.0 0.2 GO:0003407 neural retina development(GO:0003407)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.0 GO:0021542 dentate gyrus development(GO:0021542)
0.0 0.1 GO:0045618 positive regulation of keratinocyte differentiation(GO:0045618)
0.0 0.1 GO:0071305 cellular response to vitamin D(GO:0071305)
0.0 0.0 GO:0001547 antral ovarian follicle growth(GO:0001547)
0.0 0.0 GO:0060596 mammary placode formation(GO:0060596)
0.0 0.1 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.0 0.0 GO:0014049 positive regulation of glutamate secretion(GO:0014049)
0.0 0.0 GO:0050955 thermoception(GO:0050955)
0.0 0.0 GO:0046882 negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0 0.1 GO:0031000 response to caffeine(GO:0031000)
0.0 0.0 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.0 0.1 GO:0002011 morphogenesis of an epithelial sheet(GO:0002011)
0.0 0.1 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.0 GO:0060435 bronchiole development(GO:0060435)
0.0 0.0 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.0 GO:0090025 regulation of monocyte chemotaxis(GO:0090025) positive regulation of monocyte chemotaxis(GO:0090026)
0.0 0.1 GO:0090177 establishment of planar polarity involved in neural tube closure(GO:0090177)
0.0 0.0 GO:0032353 negative regulation of hormone metabolic process(GO:0032351) negative regulation of hormone biosynthetic process(GO:0032353)
0.0 0.3 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.1 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.0 GO:0046881 positive regulation of gonadotropin secretion(GO:0032278) regulation of follicle-stimulating hormone secretion(GO:0046880) positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0 0.2 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.0 0.1 GO:0042023 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0 0.0 GO:0016081 synaptic vesicle docking(GO:0016081)
0.0 0.0 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.1 GO:0002068 glandular epithelial cell development(GO:0002068)
0.0 0.2 GO:0001755 neural crest cell migration(GO:0001755)
0.0 1.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.0 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 0.1 GO:0071318 cellular response to ATP(GO:0071318)
0.0 0.0 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.1 GO:0042596 behavioral fear response(GO:0001662) fear response(GO:0042596)
0.0 0.0 GO:0001945 lymph vessel development(GO:0001945)
0.0 0.0 GO:0003032 detection of oxygen(GO:0003032)
0.0 0.1 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.0 0.0 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0 0.1 GO:0071320 cellular response to cAMP(GO:0071320)
0.0 0.0 GO:0044320 cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0 0.1 GO:0021895 cerebral cortex neuron differentiation(GO:0021895)
0.0 0.1 GO:0008595 tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.0 0.1 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.0 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.0 GO:0060438 trachea development(GO:0060438)
0.0 0.0 GO:0030573 bile acid catabolic process(GO:0030573)
0.0 0.0 GO:0032906 transforming growth factor beta2 production(GO:0032906) regulation of transforming growth factor beta2 production(GO:0032909)
0.0 0.1 GO:0009086 methionine biosynthetic process(GO:0009086)
0.0 0.0 GO:0070254 mucus secretion(GO:0070254)
0.0 0.2 GO:2000181 negative regulation of blood vessel morphogenesis(GO:2000181)
0.0 0.3 GO:0051925 obsolete regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051925)
0.0 0.0 GO:0070099 regulation of chemokine-mediated signaling pathway(GO:0070099) negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.0 0.0 GO:0045989 positive regulation of striated muscle contraction(GO:0045989)
0.0 0.0 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.0 0.1 GO:0045725 positive regulation of glycogen biosynthetic process(GO:0045725) positive regulation of glycogen metabolic process(GO:0070875)
0.0 0.1 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.0 GO:0043116 negative regulation of vascular permeability(GO:0043116)
0.0 0.0 GO:0046322 negative regulation of fatty acid oxidation(GO:0046322)
0.0 0.0 GO:0021563 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.0 GO:0010665 striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0 0.0 GO:0002070 epithelial cell maturation(GO:0002070)
0.0 0.0 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.0 GO:0042118 endothelial cell activation(GO:0042118)
0.0 0.0 GO:0045056 transcytosis(GO:0045056)
0.0 0.0 GO:0048143 astrocyte activation(GO:0048143)
0.0 0.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.1 GO:0042745 circadian sleep/wake cycle(GO:0042745)
0.0 0.0 GO:0015864 pyrimidine nucleoside transport(GO:0015864)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.5 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.2 GO:0043259 laminin-10 complex(GO:0043259)
0.1 0.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.2 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.1 0.2 GO:0005606 laminin-1 complex(GO:0005606)
0.1 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.1 0.3 GO:0001527 microfibril(GO:0001527)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.2 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.3 GO:0098645 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.2 GO:0030673 axolemma(GO:0030673)
0.0 0.2 GO:0071437 invadopodium(GO:0071437)
0.0 0.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0031430 M band(GO:0031430)
0.0 0.3 GO:0030315 T-tubule(GO:0030315)
0.0 0.1 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.0 GO:0014704 intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0 0.3 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.4 GO:0005811 lipid particle(GO:0005811)
0.0 0.2 GO:0008091 spectrin(GO:0008091)
0.0 0.2 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.1 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 1.3 GO:0099572 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 0.1 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.1 GO:0005581 collagen trimer(GO:0005581)
0.0 0.2 GO:0031105 septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.0 GO:0001940 male pronucleus(GO:0001940)
0.0 0.1 GO:0005883 neurofilament(GO:0005883)
0.0 0.2 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.7 GO:0005604 basement membrane(GO:0005604)
0.0 0.8 GO:0030426 growth cone(GO:0030426)
0.0 0.0 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 1.3 GO:0030016 myofibril(GO:0030016)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 2.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.9 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.4 GO:0030118 clathrin coat(GO:0030118)
0.0 0.1 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.0 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.0 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.2 GO:0005913 cell-cell adherens junction(GO:0005913)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.3 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.1 0.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.2 GO:0004995 tachykinin receptor activity(GO:0004995)
0.1 0.2 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1 0.2 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 0.4 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.2 GO:0070052 collagen V binding(GO:0070052)
0.1 0.2 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.2 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1 0.2 GO:0043237 laminin-1 binding(GO:0043237)
0.1 0.2 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 0.2 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.3 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.2 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.2 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.1 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.1 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.0 0.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.1 GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0 1.6 GO:0005518 collagen binding(GO:0005518)
0.0 0.3 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.2 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.1 GO:0031708 bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0 0.2 GO:0015211 purine nucleoside transmembrane transporter activity(GO:0015211)
0.0 0.4 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.2 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.4 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.2 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.2 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.5 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.2 GO:0001228 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.1 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.1 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.0 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0 0.1 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.1 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.1 GO:0001601 peptide YY receptor activity(GO:0001601)
0.0 0.5 GO:0045296 cadherin binding(GO:0045296)
0.0 0.3 GO:0030276 clathrin binding(GO:0030276)
0.0 0.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.1 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.0 0.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.1 GO:0030955 potassium ion binding(GO:0030955)
0.0 0.1 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.1 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.1 GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0 0.1 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0 0.0 GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.1 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.1 GO:0015252 hydrogen ion channel activity(GO:0015252)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.2 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.1 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 0.2 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.1 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.2 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.0 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.0 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.1 GO:0045502 dynein binding(GO:0045502)
0.0 0.0 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0 0.1 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 0.1 GO:0004970 ionotropic glutamate receptor activity(GO:0004970)
0.0 0.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.0 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 0.0 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.2 GO:0043498 obsolete cell surface binding(GO:0043498)
0.0 0.1 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.2 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.1 GO:0051378 serotonin binding(GO:0051378)
0.0 0.1 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.1 GO:0048019 receptor antagonist activity(GO:0048019)
0.0 0.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0030553 cGMP binding(GO:0030553)
0.0 0.0 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.0 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.1 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.0 GO:0035252 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.1 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.1 GO:0004047 aminomethyltransferase activity(GO:0004047)
0.0 0.1 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.1 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.3 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.1 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.0 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.0 GO:0048185 activin binding(GO:0048185)
0.0 0.1 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.0 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.1 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 0.4 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 0.3 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.5 GO:0005262 calcium channel activity(GO:0005262)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 1.9 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.2 PID IGF1 PATHWAY IGF1 pathway
0.0 0.1 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.0 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 0.0 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.3 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.1 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.1 PID ALK1 PATHWAY ALK1 signaling events
0.0 2.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.0 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.5 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.3 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.0 0.1 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 REACTOME SIGNALING BY ERBB4 Genes involved in Signaling by ERBB4
0.1 0.1 REACTOME REGULATION OF APOPTOSIS Genes involved in Regulation of Apoptosis
0.0 0.5 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.5 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.4 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.2 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.3 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.2 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.3 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.6 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.3 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.0 REACTOME ORC1 REMOVAL FROM CHROMATIN Genes involved in Orc1 removal from chromatin
0.0 0.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.2 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.2 REACTOME GRB2 EVENTS IN ERBB2 SIGNALING Genes involved in GRB2 events in ERBB2 signaling
0.0 0.1 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.3 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.0 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.3 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.1 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.0 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.2 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.0 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.1 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.2 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.1 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.1 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.1 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 0.0 REACTOME GAP JUNCTION TRAFFICKING Genes involved in Gap junction trafficking
0.0 0.3 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.1 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.1 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.1 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.0 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels