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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for DRGX_PROP1

Z-value: 0.76

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Transcription factors associated with DRGX_PROP1

Gene Symbol Gene ID Gene Info
DRGX
ENSG00000165606.4 dorsal root ganglia homeobox
PROP1
ENSG00000175325.2 PROP paired-like homeobox 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr10_50606076_50606780DRGX29310.2665520.862.8e-03Click!
chr5_177411424_177411575PROP1117440.1479870.684.3e-02Click!
chr5_177411774_177412187PROP1112630.1490680.608.7e-02Click!
chr5_177412450_177412601PROP1107180.1503310.206.0e-01Click!

Activity of the DRGX_PROP1 motif across conditions

Conditions sorted by the z-value of the DRGX_PROP1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr16_54968513_54968925 1.25 IRX5
 iroquois homeobox 5
 2735
 0.43
chr22_36310772_36312004 1.00 RBFOX2
 RNA binding protein, fox-1 homolog (C. elegans) 2
 23557
 0.25
chr4_187647302_187647732 0.99 FAT1
 FAT atypical cadherin 1
 359
 0.93
chr15_37179413_37179956 0.85 ENSG00000212511
 .
 34843
 0.22
chr11_131780111_131780399 0.81 NTM
 neurotrimin
 642
 0.77
chr1_120217864_120218312 0.80 ZNF697
 zinc finger protein 697
 27692
 0.16
chr1_240250348_240250507 0.79 FMN2
 formin 2
 4753
 0.3
chr12_49762046_49762218 0.77 SPATS2
 spermatogenesis associated, serine-rich 2
 802
 0.53
chr1_179111271_179111703 0.77 ABL2
 c-abl oncogene 2, non-receptor tyrosine kinase
 692
 0.72
chr15_38545953_38546360 0.75 SPRED1
 sprouty-related, EVH1 domain containing 1
 774
 0.79
chr7_27202641_27202952 0.71 HOXA9
 homeobox A9
 2349
 0.09
chr11_121593168_121593875 0.70 SORL1
 sortilin-related receptor, L(DLR class) A repeats containing
 132393
 0.05
chr4_159091107_159091452 0.69 FAM198B
 family with sequence similarity 198, member B
 251
 0.77
chr2_54682726_54683239 0.68 SPTBN1
 spectrin, beta, non-erythrocytic 1
 440
 0.88
chr2_197852125_197852688 0.68 ANKRD44
 ankyrin repeat domain 44
 12820
 0.25
chr16_53244996_53245358 0.67 CHD9
 chromodomain helicase DNA binding protein 9
 2814
 0.29
chr12_59311795_59312096 0.67 LRIG3
 leucine-rich repeats and immunoglobulin-like domains 3
 1382
 0.46
chr3_79066923_79067090 0.65 ROBO1
 roundabout, axon guidance receptor, homolog 1 (Drosophila)
 688
 0.81
chr21_28214648_28215240 0.64 ADAMTS1
 ADAM metallopeptidase with thrombospondin type 1 motif, 1
 393
 0.9
chr22_46462951_46463814 0.63 RP6-109B7.4
2389
 0.16
chr4_138045655_138046009 0.63 ENSG00000222526
 .
 103450
 0.09
chr14_45433796_45433989 0.62 FAM179B
 family with sequence similarity 179, member B
 2450
 0.23
chr13_38172411_38172686 0.60 POSTN
 periostin, osteoblast specific factor
 315
 0.95
chr18_60385543_60385694 0.59 PHLPP1
 PH domain and leucine rich repeat protein phosphatase 1
 2935
 0.28
chr9_12777034_12777185 0.59 LURAP1L
 leucine rich adaptor protein 1-like
 2089
 0.33
chr12_3308931_3310293 0.58 TSPAN9
 tetraspanin 9
 729
 0.75
chr3_88191159_88191414 0.58 ZNF654
 zinc finger protein 654
 3032
 0.24
chr17_79374852_79375003 0.56 ENSG00000266392
 .
 349
 0.75
chr4_54187854_54188041 0.55 SCFD2
 sec1 family domain containing 2
 44281
 0.15
chr2_16831792_16832248 0.55 FAM49A
 family with sequence similarity 49, member A
 15076
 0.3
chr2_151334124_151334616 0.55 RND3
 Rho family GTPase 3
 7526
 0.34
chr3_79066759_79066910 0.54 ROBO1
 roundabout, axon guidance receptor, homolog 1 (Drosophila)
 860
 0.75
chr6_56405555_56405706 0.54 DST
 dystonin
 66842
 0.13
chr20_56706361_56706780 0.53 C20orf85
 chromosome 20 open reading frame 85
 19390
 0.21
chr8_24867956_24868211 0.53 CTD-2168K21.2
53948
 0.14
chr8_49468858_49469448 0.52 RP11-770E5.1
5026
 0.35
chr16_24999320_24999715 0.52 ARHGAP17
 Rho GTPase activating protein 17
 27135
 0.22
chr5_94416178_94416653 0.52 MCTP1
 multiple C2 domains, transmembrane 1
 771
 0.78
chr6_169651321_169651472 0.51 THBS2
 thrombospondin 2
 850
 0.72
chr14_71067961_71068112 0.51 MED6
 mediator complex subunit 6
 652
 0.7
chr6_116833589_116833880 0.51 TRAPPC3L
 trafficking protein particle complex 3-like
 228
 0.83
chr15_62917508_62917659 0.51 RP11-625H11.1
 Uncharacterized protein
 19797
 0.2
chr17_35851874_35852313 0.50 DUSP14
 dual specificity phosphatase 14
 523
 0.79
chrX_106241917_106242068 0.50 MORC4
 MORC family CW-type zinc finger 4
 1316
 0.53
chr1_210424215_210424840 0.50 SERTAD4-AS1
 SERTAD4 antisense RNA 1
 17135
 0.21
chr13_52979416_52980324 0.50 THSD1
 thrombospondin, type I, domain containing 1
 393
 0.85
chr3_12328729_12329240 0.49 PPARG
 peroxisome proliferator-activated receptor gamma
 97
 0.98
chr12_26379464_26379833 0.49 SSPN
 sarcospan
 31042
 0.17
chr15_96897591_96898313 0.49 AC087477.1
 Uncharacterized protein
 6535
 0.18
chr4_187646786_187647042 0.49 FAT1
 FAT atypical cadherin 1
 962
 0.7
chr12_64581322_64581595 0.49 ENSG00000212298
 .
 17115
 0.15
chr1_157013915_157014350 0.49 ARHGEF11
 Rho guanine nucleotide exchange factor (GEF) 11
 733
 0.68
chr1_89197420_89197765 0.49 PKN2
 protein kinase N2
 39546
 0.16
chr6_27859319_27859470 0.49 HIST1H3J
 histone cluster 1, H3j
 824
 0.31
chr1_179110399_179110598 0.49 ABL2
 c-abl oncogene 2, non-receptor tyrosine kinase
 1681
 0.39
chr4_89514978_89515129 0.49 HERC3
 HECT and RLD domain containing E3 ubiquitin protein ligase 3
 524
 0.77
chr2_101437792_101437972 0.48 NPAS2
 neuronal PAS domain protein 2
 395
 0.8
chr1_95436764_95437146 0.48 RP4-639F20.1
10074
 0.2
chr8_18577899_18578296 0.48 RP11-161I2.1
318
 0.92
chr15_36043742_36043931 0.48 ENSG00000265098
 .
 175221
 0.03
chr11_133990232_133990720 0.48 NCAPD3
 non-SMC condensin II complex, subunit D3
 47891
 0.12
chr4_48332309_48332534 0.47 SLAIN2
 SLAIN motif family, member 2
 10918
 0.24
chr7_13985407_13985644 0.47 ETV1
 ets variant 1
 40541
 0.2
chr7_25901481_25901888 0.47 ENSG00000199085
 .
 87922
 0.1
chr12_28121780_28121931 0.47 PTHLH
 parathyroid hormone-like hormone
 572
 0.79
chr5_54456456_54456818 0.45 GPX8
 glutathione peroxidase 8 (putative)
 639
 0.58
chr18_7568558_7569022 0.44 PTPRM
 protein tyrosine phosphatase, receptor type, M
 973
 0.7
chr20_34463775_34463999 0.44 ENSG00000201221
 .
 11694
 0.14
chr6_125420988_125421372 0.44 TPD52L1
 tumor protein D52-like 1
 19015
 0.24
chr14_51909020_51909357 0.44 FRMD6
 FERM domain containing 6
 46667
 0.16
chr1_212643718_212643913 0.44 NENF
 neudesin neurotrophic factor
 37586
 0.14
chr10_33620140_33620362 0.44 NRP1
 neuropilin 1
 3059
 0.34
chr12_75841002_75841191 0.44 GLIPR1
 GLI pathogenesis-related 1
 33364
 0.14
chr4_48701412_48701950 0.44 FRYL
 FRY-like
 18493
 0.24
chr18_52988378_52989650 0.44 TCF4
 transcription factor 4
 203
 0.97
chr19_30719241_30719606 0.44 ZNF536
 zinc finger protein 536
 2
 0.73
chr1_54199074_54199253 0.43 GLIS1
 GLIS family zinc finger 1
 714
 0.69
chr6_16737749_16737900 0.43 RP1-151F17.1
23545
 0.22
chr13_40139928_40140149 0.43 LHFP
 lipoma HMGIC fusion partner
 37270
 0.18
chr17_33391542_33391948 0.43 RFFL
 ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
 874
 0.45
chr5_53753293_53753597 0.43 HSPB3
 heat shock 27kDa protein 3
 2000
 0.44
chr9_5631788_5632177 0.43 KIAA1432
 KIAA1432
 2655
 0.36
chr11_35188701_35188984 0.42 CD44
 CD44 molecule (Indian blood group)
 9276
 0.17
chr3_136505464_136505764 0.42 SLC35G2
 solute carrier family 35, member G2
 32247
 0.12
chr12_75784171_75784441 0.42 CAPS2
 calcyphosine 2
 375
 0.6
chrX_114829080_114829277 0.42 PLS3
 plastin 3
 1313
 0.48
chr21_38219417_38219579 0.42 ENSG00000199806
 .
 4713
 0.25
chr8_89338531_89338740 0.42 RP11-586K2.1
430
 0.76
chr1_184858090_184858241 0.42 ENSG00000252222
 .
 67542
 0.11
chr7_116141197_116141631 0.42 CAV2
 caveolin 2
 1580
 0.29
chr15_98506044_98506195 0.41 ARRDC4
 arrestin domain containing 4
 2191
 0.38
chr12_47219854_47220069 0.41 SLC38A4
 solute carrier family 38, member 4
 181
 0.97
chr5_142623144_142623555 0.41 ARHGAP26
 Rho GTPase activating protein 26
 36584
 0.19
chr1_95330057_95330663 0.41 SLC44A3
 solute carrier family 44, member 3
 2527
 0.28
chr6_121758427_121758731 0.40 GJA1
 gap junction protein, alpha 1, 43kDa
 1741
 0.35
chr4_39938923_39939074 0.40 ENSG00000252970
 .
 625
 0.75
chr21_36264537_36264739 0.40 RUNX1
 runt-related transcription factor 1
 2551
 0.42
chr7_32099128_32099768 0.40 PDE1C
 phosphodiesterase 1C, calmodulin-dependent 70kDa
 11013
 0.32
chr9_708078_708584 0.40 KANK1
 KN motif and ankyrin repeat domains 1
 1442
 0.47
chr8_16576311_16576462 0.40 ENSG00000264092
 .
 144619
 0.05
chr8_37678948_37679463 0.39 GPR124
 G protein-coupled receptor 124
 24431
 0.12
chr16_86599945_86600151 0.39 FOXC2
 forkhead box C2 (MFH-1, mesenchyme forkhead 1)
 809
 0.48
chr19_13136767_13137028 0.39 NFIX
 nuclear factor I/X (CCAAT-binding transcription factor)
 1086
 0.34
chr10_12095697_12095857 0.39 UPF2
 UPF2 regulator of nonsense transcripts homolog (yeast)
 10754
 0.17
chr17_67137246_67137397 0.39 ABCA6
 ATP-binding cassette, sub-family A (ABC1), member 6
 694
 0.69
chr1_68697735_68698156 0.39 WLS
 wntless Wnt ligand secretion mediator
 18
 0.98
chr18_74202036_74202284 0.39 ZNF516
 zinc finger protein 516
 575
 0.66
chr4_87935725_87935950 0.39 AFF1
 AF4/FMR2 family, member 1
 7416
 0.29
chr18_30563491_30563642 0.38 RP11-680N20.1
29527
 0.24
chr20_10502111_10502382 0.38 SLX4IP
 SLX4 interacting protein
 86295
 0.09
chr7_82188634_82189045 0.38 CACNA2D1
 calcium channel, voltage-dependent, alpha 2/delta subunit 1
 115725
 0.07
chr2_36924982_36925262 0.38 VIT
 vitrin
 1102
 0.6
chr1_119529068_119529220 0.38 TBX15
 T-box 15
 1284
 0.57
chr5_88120627_88121096 0.37 MEF2C
 myocyte enhancer factor 2C
 704
 0.78
chr2_64926239_64926446 0.37 SERTAD2
 SERTA domain containing 2
 45295
 0.15
chr8_16689434_16690090 0.37 ENSG00000264092
 .
 31243
 0.24
chr3_181434209_181434555 0.37 SOX2
 SRY (sex determining region Y)-box 2
 4660
 0.26
chr2_200446222_200446758 0.37 SATB2
 SATB homeobox 2
 110501
 0.07
chr4_15010597_15010748 0.37 CPEB2
 cytoplasmic polyadenylation element binding protein 2
 5112
 0.32
chr10_119132010_119132432 0.37 PDZD8
 PDZ domain containing 8
 2757
 0.3
chr5_88027797_88028081 0.37 CTC-467M3.2
39471
 0.16
chr11_102959875_102960225 0.37 DCUN1D5
 DCN1, defective in cullin neddylation 1, domain containing 5
 3
 0.98
chr9_80409118_80409269 0.37 GNAQ
 guanine nucleotide binding protein (G protein), q polypeptide
 28722
 0.25
chr18_67713592_67713743 0.37 RTTN
 rotatin
 25713
 0.25
chr15_56206090_56206310 0.36 NEDD4
 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
 1652
 0.45
chr3_136677766_136677917 0.36 IL20RB
 interleukin 20 receptor beta
 990
 0.56
chr1_39860957_39861272 0.36 KIAA0754
 KIAA0754
 15037
 0.18
chr8_70406794_70407007 0.36 SULF1
 sulfatase 1
 1872
 0.5
chr7_123390243_123390394 0.36 RP11-390E23.6
1196
 0.34
chr1_23696524_23696675 0.36 ENSG00000201405
 .
 148
 0.82
chr12_66220556_66220804 0.36 HMGA2
 high mobility group AT-hook 2
 1777
 0.39
chr13_39945288_39945439 0.36 ENSG00000238408
 .
 75990
 0.12
chr2_189247602_189247926 0.36 ENSG00000207951
 .
 85545
 0.09
chr12_78336292_78336638 0.35 NAV3
 neuron navigator 3
 23591
 0.28
chr22_35778076_35778227 0.35 HMOX1
 heme oxygenase (decycling) 1
 1323
 0.43
chr10_119303944_119304573 0.35 EMX2OS
 EMX2 opposite strand/antisense RNA
 321
 0.88
chr4_61665381_61665532 0.35 ENSG00000265829
 .
 122881
 0.06
chr6_26577102_26577344 0.35 ABT1
 activator of basal transcription 1
 19957
 0.15
chr5_53386895_53387046 0.35 ENSG00000265421
 .
 15557
 0.24
chr9_96902091_96902301 0.35 ENSG00000199165
 .
 36038
 0.13
chr2_237479145_237479357 0.35 ACKR3
 atypical chemokine receptor 3
 967
 0.68
chr1_86048991_86049142 0.35 CYR61
 cysteine-rich, angiogenic inducer, 61
 2622
 0.26
chr2_171381865_171382027 0.35 AC007277.3
118508
 0.06
chr5_139418219_139418461 0.35 NRG2
 neuregulin 2
 4314
 0.21
chr2_12842465_12842741 0.35 TRIB2
 tribbles pseudokinase 2
 14412
 0.26
chr3_126500993_126501380 0.35 CHCHD6
 coiled-coil-helix-coiled-coil-helix domain containing 6
 51779
 0.16
chr22_44722319_44722530 0.35 KIAA1644
 KIAA1644
 13693
 0.24
chr4_114388823_114389059 0.35 CAMK2D
 calcium/calmodulin-dependent protein kinase II delta
 46057
 0.14
chr15_38548551_38548873 0.35 SPRED1
 sprouty-related, EVH1 domain containing 1
 3330
 0.39
chr10_54202834_54203158 0.34 RP11-556E13.1
117869
 0.06
chr5_61389615_61389794 0.34 ENSG00000251983
 .
 52788
 0.18
chr21_32715523_32716836 0.34 TIAM1
 T-cell lymphoma invasion and metastasis 1
 415
 0.91
chr6_111582018_111582254 0.34 KIAA1919
 KIAA1919
 1585
 0.29
chr13_21388856_21389007 0.34 N6AMT2
 N-6 adenine-specific DNA methyltransferase 2 (putative)
 40843
 0.16
chr2_98765349_98765752 0.34 VWA3B
 von Willebrand factor A domain containing 3B
 61851
 0.13
chr14_32037334_32037518 0.34 NUBPL
 nucleotide binding protein-like
 6596
 0.17
chr4_184040476_184040627 0.34 WWC2
 WW and C2 domain containing 2
 19906
 0.19
chr4_114705923_114706074 0.34 CAMK2D
 calcium/calmodulin-dependent protein kinase II delta
 22915
 0.27
chr8_107738861_107739281 0.34 OXR1
 oxidation resistance 1
 658
 0.71
chr9_123919065_123919216 0.34 CNTRL
 centriolin
 981
 0.55
chr12_125170011_125170375 0.33 NCOR2
 nuclear receptor corepressor 2
 118183
 0.06
chr7_78911351_78911863 0.33 ENSG00000212482
 .
 61081
 0.15
chr7_116222889_116223134 0.33 AC006159.4
11723
 0.18
chr4_23890359_23890765 0.33 PPARGC1A
 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
 1096
 0.66
chr14_50692436_50692613 0.33 SOS2
 son of sevenless homolog 2 (Drosophila)
 5503
 0.22
chr5_66254399_66254664 0.33 MAST4
 microtubule associated serine/threonine kinase family member 4
 167
 0.97
chr14_35179773_35180008 0.33 CFL2
 cofilin 2 (muscle)
 3144
 0.26
chr11_94503028_94503179 0.33 AMOTL1
 angiomotin like 1
 1566
 0.45
chr4_102277312_102277561 0.33 PPP3CA
 protein phosphatase 3, catalytic subunit, alpha isozyme
 8001
 0.2
chr14_29254002_29254283 0.33 RP11-966I7.2
851
 0.56
chr2_197831476_197831662 0.33 ANKRD44
 ankyrin repeat domain 44
 33657
 0.18
chr17_27719677_27719955 0.33 TAOK1
 TAO kinase 1
 1867
 0.18
chr12_78334931_78335200 0.33 NAV3
 neuron navigator 3
 24991
 0.28
chr14_79747812_79748200 0.33 NRXN3
 neurexin 3
 1757
 0.44
chr9_97666762_97667035 0.32 RP11-49O14.2
4187
 0.23
chr1_68297324_68297475 0.32 GNG12-AS1
 GNG12 antisense RNA 1
 587
 0.71
chr21_17679599_17679750 0.32 ENSG00000201025
 .
 22585
 0.28
chr8_32441619_32441833 0.32 NRG1
 neuregulin 1
 21440
 0.28
chr1_71831333_71831497 0.32 ENSG00000229956
 .
 35990
 0.23
chr4_81192022_81192173 0.32 FGF5
 fibroblast growth factor 5
 4304
 0.29
chr2_110656312_110656910 0.32 LIMS3
 LIM and senescent cell antigen-like domains 3
 343
 0.93
chr10_29916878_29917029 0.32 SVIL
 supervillin
 6948
 0.21
chr12_8814882_8815352 0.32 MFAP5
 microfibrillar associated protein 5
 98
 0.95
chr6_10409161_10409312 0.32 TFAP2A-AS1
 TFAP2A antisense RNA 1
 337
 0.8
chr10_33665800_33666194 0.32 NRP1
 neuropilin 1
 40807
 0.2
chr15_56205778_56205950 0.32 NEDD4
 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
 1988
 0.4
chr7_7197772_7198055 0.32 C1GALT1
 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
 1348
 0.45
chr4_176692255_176692416 0.32 GPM6A
 glycoprotein M6A
 16203
 0.23
chr15_25638050_25638201 0.32 UBE3A
 ubiquitin protein ligase E3A
 12528
 0.11
chr14_79426395_79426572 0.32 CTD-2243E23.1
114622
 0.07
chr4_54424539_54424751 0.31 LNX1
 ligand of numb-protein X 1, E3 ubiquitin protein ligase
 261
 0.93
chr20_14316163_14316462 0.31 FLRT3
 fibronectin leucine rich transmembrane protein 3
 1942
 0.4
chr3_151694269_151694458 0.31 RP11-454C18.2
48400
 0.17
chr6_3180552_3180703 0.31 TUBB2A
 tubulin, beta 2A class IIa
 22867
 0.13
chr20_7148010_7148161 0.31 ENSG00000251833
 .
 306424
 0.01
chr18_56532811_56532962 0.31 ZNF532
 zinc finger protein 532
 100
 0.97
chr2_12928938_12929131 0.31 ENSG00000264370
 .
 51541
 0.17
chr2_109271526_109272143 0.31 LIMS1
 LIM and senescent cell antigen-like domains 1
 325
 0.91
chr6_125684129_125684280 0.31 RP11-735G4.1
11266
 0.27
chr4_170069363_170069514 0.31 RP11-327O17.2
53507
 0.15

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of DRGX_PROP1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0050923 regulation of negative chemotaxis(GO:0050923)
0.2 0.6 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.2 0.8 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 0.4 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.1 0.4 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.1 0.4 GO:0010842 retina layer formation(GO:0010842)
0.1 0.2 GO:0031223 auditory behavior(GO:0031223)
0.1 0.5 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.1 0.3 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.1 0.2 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.1 0.3 GO:0048342 paraxial mesodermal cell differentiation(GO:0048342) paraxial mesodermal cell fate commitment(GO:0048343)
0.1 0.6 GO:0060347 heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.1 0.2 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.1 0.3 GO:0010665 striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.1 0.1 GO:0060435 bronchiole development(GO:0060435)
0.1 0.5 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 0.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.3 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.1 0.1 GO:0048520 positive regulation of behavior(GO:0048520)
0.1 0.1 GO:2000178 negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.1 0.2 GO:0071694 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1 0.7 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.1 0.2 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1 0.2 GO:0060174 limb bud formation(GO:0060174)
0.1 0.1 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.1 0.2 GO:0008354 germ cell migration(GO:0008354)
0.1 0.3 GO:0060997 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.1 0.2 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.1 0.2 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.0 0.2 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.0 0.1 GO:0061072 iris morphogenesis(GO:0061072)
0.0 0.6 GO:0007184 SMAD protein import into nucleus(GO:0007184)
0.0 0.3 GO:1901532 regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0 0.1 GO:0032413 negative regulation of ion transmembrane transporter activity(GO:0032413)
0.0 0.2 GO:0035066 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.2 GO:0070141 response to UV-A(GO:0070141)
0.0 0.0 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0 0.0 GO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0032236 obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0 0.1 GO:0021563 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.1 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.0 GO:0001743 optic placode formation(GO:0001743)
0.0 0.2 GO:0006533 aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.0 0.1 GO:0051451 myoblast migration(GO:0051451)
0.0 0.2 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.3 GO:0030853 negative regulation of granulocyte differentiation(GO:0030853)
0.0 0.2 GO:0042023 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0 0.2 GO:0002052 positive regulation of neuroblast proliferation(GO:0002052)
0.0 0.2 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.0 0.2 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.2 GO:0014805 smooth muscle adaptation(GO:0014805)
0.0 0.2 GO:0022617 extracellular matrix disassembly(GO:0022617)
0.0 0.1 GO:0032823 natural killer cell differentiation(GO:0001779) regulation of natural killer cell differentiation(GO:0032823) positive regulation of natural killer cell differentiation(GO:0032825)
0.0 0.0 GO:0060841 venous blood vessel development(GO:0060841)
0.0 0.1 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.1 GO:0044415 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.1 GO:0010107 potassium ion import(GO:0010107)
0.0 0.7 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.3 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0 0.1 GO:0051940 regulation of neurotransmitter uptake(GO:0051580) regulation of dopamine uptake involved in synaptic transmission(GO:0051584) regulation of catecholamine uptake involved in synaptic transmission(GO:0051940)
0.0 0.0 GO:0090081 regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081)
0.0 0.2 GO:0045992 negative regulation of embryonic development(GO:0045992)
0.0 0.1 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.1 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.1 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.0 0.4 GO:0042745 circadian sleep/wake cycle(GO:0042745)
0.0 0.1 GO:0009822 alkaloid catabolic process(GO:0009822)
0.0 0.8 GO:0051353 positive regulation of oxidoreductase activity(GO:0051353)
0.0 0.1 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0 0.1 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.1 GO:0060677 ureteric bud elongation(GO:0060677)
0.0 0.1 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.1 GO:0021898 commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.1 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.1 GO:0060037 pharyngeal system development(GO:0060037)
0.0 0.2 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.1 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.0 0.0 GO:0060594 mammary gland specification(GO:0060594)
0.0 0.1 GO:0006449 regulation of translational termination(GO:0006449)
0.0 0.2 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.1 GO:0021591 ventricular system development(GO:0021591)
0.0 0.0 GO:1901419 regulation of response to alcohol(GO:1901419)
0.0 0.2 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.1 GO:0033024 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0 0.1 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.0 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.0 GO:0021892 cerebral cortex GABAergic interneuron differentiation(GO:0021892)
0.0 0.1 GO:0061004 pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048) pattern specification involved in metanephros development(GO:0072268)
0.0 0.1 GO:0043457 regulation of cellular respiration(GO:0043457)
0.0 0.2 GO:0002076 osteoblast development(GO:0002076)
0.0 0.1 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0 0.1 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.1 GO:0033504 floor plate development(GO:0033504)
0.0 0.1 GO:0097435 extracellular fibril organization(GO:0043206) fibril organization(GO:0097435)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.1 GO:0060638 mesenchymal-epithelial cell signaling(GO:0060638)
0.0 0.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.1 GO:0060900 optic cup morphogenesis involved in camera-type eye development(GO:0002072) embryonic camera-type eye formation(GO:0060900)
0.0 0.2 GO:0046033 AMP metabolic process(GO:0046033)
0.0 0.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.0 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
0.0 0.1 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.0 GO:0060242 contact inhibition(GO:0060242)
0.0 0.3 GO:0008210 estrogen metabolic process(GO:0008210)
0.0 0.1 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 0.4 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.0 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.0 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)
0.0 0.1 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 0.0 GO:0030812 negative regulation of nucleotide catabolic process(GO:0030812) negative regulation of nucleoside metabolic process(GO:0045978) negative regulation of ATP metabolic process(GO:1903579)
0.0 0.1 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.1 GO:0021800 cerebral cortex tangential migration(GO:0021800)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.0 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.2 GO:0000052 citrulline metabolic process(GO:0000052)
0.0 0.0 GO:0090030 regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347) regulation of steroid hormone biosynthetic process(GO:0090030)
0.0 0.2 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.4 GO:0008038 neuron recognition(GO:0008038)
0.0 0.1 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.0 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.2 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.1 GO:0016322 neuron remodeling(GO:0016322)
0.0 0.1 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0 0.1 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.1 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 0.1 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.3 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.3 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.0 0.1 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.0 0.2 GO:0007416 synapse assembly(GO:0007416)
0.0 0.1 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0046322 negative regulation of fatty acid oxidation(GO:0046322)
0.0 0.0 GO:0033091 positive regulation of immature T cell proliferation(GO:0033091)
0.0 0.1 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.1 GO:0045618 positive regulation of keratinocyte differentiation(GO:0045618)
0.0 0.2 GO:0007567 parturition(GO:0007567)
0.0 0.1 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.0 0.0 GO:0032351 negative regulation of hormone metabolic process(GO:0032351) negative regulation of hormone biosynthetic process(GO:0032353)
0.0 0.0 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.3 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.0 GO:0001306 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0 0.0 GO:0019336 phenol-containing compound catabolic process(GO:0019336) catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0 0.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.1 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.0 0.0 GO:0002118 aggressive behavior(GO:0002118)
0.0 0.1 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0 0.0 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.1 GO:0046325 negative regulation of glucose transport(GO:0010829) negative regulation of glucose import(GO:0046325)
0.0 0.0 GO:0007412 axon target recognition(GO:0007412)
0.0 0.1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.1 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.0 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.2 GO:0030299 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.0 0.1 GO:0043438 acetoacetic acid metabolic process(GO:0043438)
0.0 0.1 GO:0001974 blood vessel remodeling(GO:0001974)
0.0 1.1 GO:0030198 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.0 GO:0060023 soft palate development(GO:0060023)
0.0 0.0 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 0.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 2.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.0 GO:0046881 positive regulation of gonadotropin secretion(GO:0032278) positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0 0.1 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0 0.0 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.0 0.2 GO:0050999 regulation of nitric-oxide synthase activity(GO:0050999)
0.0 0.0 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.0 0.1 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.0 GO:0030202 heparin metabolic process(GO:0030202)
0.0 0.0 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.0 0.1 GO:0008218 bioluminescence(GO:0008218)
0.0 0.1 GO:0097094 cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0 0.1 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.0 0.0 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.1 GO:0090399 replicative senescence(GO:0090399)
0.0 0.0 GO:0022038 corpus callosum development(GO:0022038)
0.0 0.0 GO:0021778 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0 0.0 GO:0048539 bone marrow development(GO:0048539)
0.0 0.1 GO:0021513 spinal cord dorsal/ventral patterning(GO:0021513)
0.0 0.0 GO:0021570 rhombomere 4 development(GO:0021570)
0.0 0.0 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.1 GO:0033599 regulation of mammary gland epithelial cell proliferation(GO:0033599)
0.0 0.1 GO:0046184 aldehyde biosynthetic process(GO:0046184)
0.0 0.0 GO:0061525 hindgut morphogenesis(GO:0007442) hindgut development(GO:0061525)
0.0 0.0 GO:0021930 cell proliferation in hindbrain(GO:0021534) cell proliferation in external granule layer(GO:0021924) cerebellar granule cell precursor proliferation(GO:0021930)
0.0 0.0 GO:0003211 cardiac chamber formation(GO:0003207) cardiac ventricle formation(GO:0003211)
0.0 0.0 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.0 0.0 GO:2000050 regulation of non-canonical Wnt signaling pathway(GO:2000050)
0.0 0.0 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.0 GO:0003352 regulation of cilium movement(GO:0003352) regulation of cilium beat frequency(GO:0003356) cilium movement involved in cell motility(GO:0060294) regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.0 0.0 GO:1903332 regulation of protein folding(GO:1903332)
0.0 0.2 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.0 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0 0.0 GO:0071501 SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.1 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.0 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 0.1 GO:0009200 deoxyribonucleoside triphosphate metabolic process(GO:0009200)
0.0 0.1 GO:0048169 regulation of long-term neuronal synaptic plasticity(GO:0048169)
0.0 0.0 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.1 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.0 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.0 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.0 GO:0048333 mesodermal cell differentiation(GO:0048333)
0.0 0.4 GO:0001843 neural tube closure(GO:0001843) tube closure(GO:0060606)
0.0 0.0 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.0 GO:0000089 mitotic metaphase(GO:0000089)
0.0 0.0 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 0.1 GO:0032330 regulation of chondrocyte differentiation(GO:0032330)
0.0 0.0 GO:0072110 cellular response to heparin(GO:0071504) glomerular mesangial cell proliferation(GO:0072110) regulation of glomerular mesangial cell proliferation(GO:0072124)
0.0 0.1 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.1 GO:0002040 sprouting angiogenesis(GO:0002040)
0.0 0.0 GO:0001738 morphogenesis of a polarized epithelium(GO:0001738)
0.0 0.1 GO:0043113 receptor clustering(GO:0043113)
0.0 0.0 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.1 GO:0002675 positive regulation of acute inflammatory response(GO:0002675)
0.0 0.0 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.1 GO:0060612 adipose tissue development(GO:0060612)
0.0 0.1 GO:0008347 glial cell migration(GO:0008347)
0.0 0.0 GO:0003032 detection of oxygen(GO:0003032)
0.0 0.1 GO:0048286 lung alveolus development(GO:0048286)
0.0 0.0 GO:0046349 amino sugar biosynthetic process(GO:0046349)
0.0 0.3 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.1 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.0 0.1 GO:0040036 regulation of fibroblast growth factor receptor signaling pathway(GO:0040036)
0.0 0.2 GO:0030520 intracellular estrogen receptor signaling pathway(GO:0030520)
0.0 0.1 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.0 GO:0033345 asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.0 0.2 GO:0051925 obsolete regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051925)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.4 GO:0001527 microfibril(GO:0001527)
0.1 0.3 GO:0071437 invadopodium(GO:0071437)
0.1 0.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.2 GO:0043259 laminin-10 complex(GO:0043259)
0.1 0.2 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.2 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.3 GO:0008091 spectrin(GO:0008091)
0.0 0.2 GO:0043205 fibril(GO:0043205)
0.0 0.1 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.1 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.7 GO:0005811 lipid particle(GO:0005811)
0.0 0.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.2 GO:0005915 zonula adherens(GO:0005915)
0.0 0.2 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.2 GO:0005916 fascia adherens(GO:0005916)
0.0 0.1 GO:0005606 laminin-1 complex(GO:0005606)
0.0 0.1 GO:0002142 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0 0.3 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.1 GO:0045277 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.0 0.0 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.2 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:0031512 motile primary cilium(GO:0031512)
0.0 0.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.0 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.0 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.1 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.0 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 1.0 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 1.4 GO:0099572 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 0.9 GO:0005604 basement membrane(GO:0005604)
0.0 0.2 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.1 GO:0030128 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0 0.3 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.2 GO:0005675 holo TFIIH complex(GO:0005675)
0.0 0.1 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.0 GO:0070852 cell body fiber(GO:0070852)
0.0 0.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.0 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.8 GO:0030426 growth cone(GO:0030426)
0.0 0.0 GO:0030673 axolemma(GO:0030673)
0.0 0.3 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.0 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0000300 obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0 2.2 GO:0005911 cell-cell junction(GO:0005911)
0.0 0.0 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 0.0 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.0 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.1 GO:0071565 nBAF complex(GO:0071565)
0.0 0.0 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 0.5 GO:0050544 arachidonic acid binding(GO:0050544)
0.2 0.5 GO:0000987 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.2 1.0 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.4 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.1 0.4 GO:0045499 chemorepellent activity(GO:0045499)
0.1 0.6 GO:0005499 vitamin D binding(GO:0005499)
0.1 0.3 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.5 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 0.2 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.1 0.3 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1 0.2 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.1 0.3 GO:0050815 phosphoserine binding(GO:0050815)
0.1 0.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 0.7 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 0.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.3 GO:0042805 actinin binding(GO:0042805)
0.1 0.2 GO:0050682 AF-2 domain binding(GO:0050682)
0.1 0.2 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 0.2 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.4 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0 0.1 GO:0016149 translation release factor activity, codon specific(GO:0016149)
0.0 0.2 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.1 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.3 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.5 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.4 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.2 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.1 GO:0050897 cobalt ion binding(GO:0050897)
0.0 0.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.1 GO:0035198 miRNA binding(GO:0035198)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.0 0.1 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.4 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.1 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.9 GO:0030145 manganese ion binding(GO:0030145)
0.0 0.3 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.1 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
0.0 0.1 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.1 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0 0.1 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.5 GO:0045296 cadherin binding(GO:0045296)
0.0 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.2 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.2 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.2 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 0.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.2 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.1 GO:0030172 troponin C binding(GO:0030172)
0.0 0.1 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0 0.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.0 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.1 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 1.8 GO:0008201 heparin binding(GO:0008201)
0.0 0.1 GO:0003701 obsolete RNA polymerase I transcription factor activity(GO:0003701)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.2 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.0 GO:0032554 purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0 0.1 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.2 GO:0070717 poly-purine tract binding(GO:0070717)
0.0 0.1 GO:0000403 Y-form DNA binding(GO:0000403)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.2 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.1 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.1 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.1 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.0 GO:0052834 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.0 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.1 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.4 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.0 0.2 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.1 GO:0005148 prolactin receptor binding(GO:0005148)
0.0 0.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.2 GO:0035254 glutamate receptor binding(GO:0035254)
0.0 0.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.0 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.2 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.0 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.0 GO:0016453 C-acetyltransferase activity(GO:0016453)
0.0 0.1 GO:0019841 retinol binding(GO:0019841)
0.0 0.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)
0.0 0.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.1 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.1 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.0 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.0 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.0 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.0 0.1 GO:0005109 frizzled binding(GO:0005109)
0.0 0.1 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.1 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 0.0 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.0 GO:0034186 apolipoprotein A-I binding(GO:0034186)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.0 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.1 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.3 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.6 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.6 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.1 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.1 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.1 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.1 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.4 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.7 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.6 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.6 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.1 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.2 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.3 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.3 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.1 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.0 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.2 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.2 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.4 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.1 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.4 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.1 0.9 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 1.1 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 0.2 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 1.2 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.3 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.3 REACTOME OPIOID SIGNALLING Genes involved in Opioid Signalling
0.0 0.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.2 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.3 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.5 REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION Genes involved in RORA Activates Circadian Expression
0.0 0.5 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.2 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.3 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.2 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.2 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.0 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.1 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.3 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.1 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.0 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.4 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.1 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.3 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.0 0.5 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)