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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for DRGX_PROP1

Z-value: 0.76

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Transcription factors associated with DRGX_PROP1

Gene Symbol	Gene ID	Gene Info
DRGX Ensembl NCBI GeneCards UniProt	ENSG00000165606.4	DRGX
PROP1 Ensembl NCBI GeneCards UniProt	ENSG00000175325.2	PROP1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
DRGX	chr10_50606076_50606780	2931	0.266552	0.86	2.8e-03	Click!
PROP1	chr5_177411424_177411575	11744	0.147987	0.68	4.3e-02	Click!
PROP1	chr5_177411774_177412187	11263	0.149068	0.60	8.7e-02	Click!
PROP1	chr5_177412450_177412601	10718	0.150331	0.20	6.0e-01	Click!

Activity of the DRGX_PROP1 motif across conditions

Conditions sorted by the z-value of the DRGX_PROP1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr16_54968513_54968925	1.25	IRX5	iroquois homeobox 5	2735	0.43
chr22_36310772_36312004	1.00	RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	23557	0.25
chr4_187647302_187647732	0.99	FAT1	FAT atypical cadherin 1	359	0.93
chr15_37179413_37179956	0.85	ENSG00000212511	.	34843	0.22
chr11_131780111_131780399	0.81	NTM	neurotrimin	642	0.77
chr1_120217864_120218312	0.80	ZNF697	zinc finger protein 697	27692	0.16
chr1_240250348_240250507	0.79	FMN2	formin 2	4753	0.3
chr12_49762046_49762218	0.77	SPATS2	spermatogenesis associated, serine-rich 2	802	0.53
chr1_179111271_179111703	0.77	ABL2	c-abl oncogene 2, non-receptor tyrosine kinase	692	0.72
chr15_38545953_38546360	0.75	SPRED1	sprouty-related, EVH1 domain containing 1	774	0.79
chr7_27202641_27202952	0.71	HOXA9	homeobox A9	2349	0.09
chr11_121593168_121593875	0.70	SORL1	sortilin-related receptor, L(DLR class) A repeats containing	132393	0.05
chr4_159091107_159091452	0.69	FAM198B	family with sequence similarity 198, member B	251	0.77
chr2_54682726_54683239	0.68	SPTBN1	spectrin, beta, non-erythrocytic 1	440	0.88
chr2_197852125_197852688	0.68	ANKRD44	ankyrin repeat domain 44	12820	0.25
chr16_53244996_53245358	0.67	CHD9	chromodomain helicase DNA binding protein 9	2814	0.29
chr12_59311795_59312096	0.67	LRIG3	leucine-rich repeats and immunoglobulin-like domains 3	1382	0.46
chr3_79066923_79067090	0.65	ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)	688	0.81
chr21_28214648_28215240	0.64	ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif, 1	393	0.9
chr22_46462951_46463814	0.63	RP6-109B7.4		2389	0.16
chr4_138045655_138046009	0.63	ENSG00000222526	.	103450	0.09
chr14_45433796_45433989	0.62	FAM179B	family with sequence similarity 179, member B	2450	0.23
chr13_38172411_38172686	0.60	POSTN	periostin, osteoblast specific factor	315	0.95
chr18_60385543_60385694	0.59	PHLPP1	PH domain and leucine rich repeat protein phosphatase 1	2935	0.28
chr9_12777034_12777185	0.59	LURAP1L	leucine rich adaptor protein 1-like	2089	0.33
chr12_3308931_3310293	0.58	TSPAN9	tetraspanin 9	729	0.75
chr3_88191159_88191414	0.58	ZNF654	zinc finger protein 654	3032	0.24
chr17_79374852_79375003	0.56	ENSG00000266392	.	349	0.75
chr4_54187854_54188041	0.55	SCFD2	sec1 family domain containing 2	44281	0.15
chr2_16831792_16832248	0.55	FAM49A	family with sequence similarity 49, member A	15076	0.3
chr2_151334124_151334616	0.55	RND3	Rho family GTPase 3	7526	0.34
chr3_79066759_79066910	0.54	ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)	860	0.75
chr6_56405555_56405706	0.54	DST	dystonin	66842	0.13
chr20_56706361_56706780	0.53	C20orf85	chromosome 20 open reading frame 85	19390	0.21
chr8_24867956_24868211	0.53	CTD-2168K21.2		53948	0.14
chr8_49468858_49469448	0.52	RP11-770E5.1		5026	0.35
chr16_24999320_24999715	0.52	ARHGAP17	Rho GTPase activating protein 17	27135	0.22
chr5_94416178_94416653	0.52	MCTP1	multiple C2 domains, transmembrane 1	771	0.78
chr6_169651321_169651472	0.51	THBS2	thrombospondin 2	850	0.72
chr14_71067961_71068112	0.51	MED6	mediator complex subunit 6	652	0.7
chr6_116833589_116833880	0.51	TRAPPC3L	trafficking protein particle complex 3-like	228	0.83
chr15_62917508_62917659	0.51	RP11-625H11.1	Uncharacterized protein	19797	0.2
chr17_35851874_35852313	0.50	DUSP14	dual specificity phosphatase 14	523	0.79
chrX_106241917_106242068	0.50	MORC4	MORC family CW-type zinc finger 4	1316	0.53
chr1_210424215_210424840	0.50	SERTAD4-AS1	SERTAD4 antisense RNA 1	17135	0.21
chr13_52979416_52980324	0.50	THSD1	thrombospondin, type I, domain containing 1	393	0.85
chr3_12328729_12329240	0.49	PPARG	peroxisome proliferator-activated receptor gamma	97	0.98
chr12_26379464_26379833	0.49	SSPN	sarcospan	31042	0.17
chr15_96897591_96898313	0.49	AC087477.1	Uncharacterized protein	6535	0.18
chr4_187646786_187647042	0.49	FAT1	FAT atypical cadherin 1	962	0.7
chr12_64581322_64581595	0.49	ENSG00000212298	.	17115	0.15
chr1_157013915_157014350	0.49	ARHGEF11	Rho guanine nucleotide exchange factor (GEF) 11	733	0.68
chr1_89197420_89197765	0.49	PKN2	protein kinase N2	39546	0.16
chr6_27859319_27859470	0.49	HIST1H3J	histone cluster 1, H3j	824	0.31
chr1_179110399_179110598	0.49	ABL2	c-abl oncogene 2, non-receptor tyrosine kinase	1681	0.39
chr4_89514978_89515129	0.49	HERC3	HECT and RLD domain containing E3 ubiquitin protein ligase 3	524	0.77
chr2_101437792_101437972	0.48	NPAS2	neuronal PAS domain protein 2	395	0.8
chr1_95436764_95437146	0.48	RP4-639F20.1		10074	0.2
chr8_18577899_18578296	0.48	RP11-161I2.1		318	0.92
chr15_36043742_36043931	0.48	ENSG00000265098	.	175221	0.03
chr11_133990232_133990720	0.48	NCAPD3	non-SMC condensin II complex, subunit D3	47891	0.12
chr4_48332309_48332534	0.47	SLAIN2	SLAIN motif family, member 2	10918	0.24
chr7_13985407_13985644	0.47	ETV1	ets variant 1	40541	0.2
chr7_25901481_25901888	0.47	ENSG00000199085	.	87922	0.1
chr12_28121780_28121931	0.47	PTHLH	parathyroid hormone-like hormone	572	0.79
chr5_54456456_54456818	0.45	GPX8	glutathione peroxidase 8 (putative)	639	0.58
chr18_7568558_7569022	0.44	PTPRM	protein tyrosine phosphatase, receptor type, M	973	0.7
chr20_34463775_34463999	0.44	ENSG00000201221	.	11694	0.14
chr6_125420988_125421372	0.44	TPD52L1	tumor protein D52-like 1	19015	0.24
chr14_51909020_51909357	0.44	FRMD6	FERM domain containing 6	46667	0.16
chr1_212643718_212643913	0.44	NENF	neudesin neurotrophic factor	37586	0.14
chr10_33620140_33620362	0.44	NRP1	neuropilin 1	3059	0.34
chr12_75841002_75841191	0.44	GLIPR1	GLI pathogenesis-related 1	33364	0.14
chr4_48701412_48701950	0.44	FRYL	FRY-like	18493	0.24
chr18_52988378_52989650	0.44	TCF4	transcription factor 4	203	0.97
chr19_30719241_30719606	0.44	ZNF536	zinc finger protein 536	2	0.73
chr1_54199074_54199253	0.43	GLIS1	GLIS family zinc finger 1	714	0.69
chr6_16737749_16737900	0.43	RP1-151F17.1		23545	0.22
chr13_40139928_40140149	0.43	LHFP	lipoma HMGIC fusion partner	37270	0.18
chr17_33391542_33391948	0.43	RFFL	ring finger and FYVE-like domain containing E3 ubiquitin protein ligase	874	0.45
chr5_53753293_53753597	0.43	HSPB3	heat shock 27kDa protein 3	2000	0.44
chr9_5631788_5632177	0.43	KIAA1432	KIAA1432	2655	0.36
chr11_35188701_35188984	0.42	CD44	CD44 molecule (Indian blood group)	9276	0.17
chr3_136505464_136505764	0.42	SLC35G2	solute carrier family 35, member G2	32247	0.12
chr12_75784171_75784441	0.42	CAPS2	calcyphosine 2	375	0.6
chrX_114829080_114829277	0.42	PLS3	plastin 3	1313	0.48
chr21_38219417_38219579	0.42	ENSG00000199806	.	4713	0.25
chr8_89338531_89338740	0.42	RP11-586K2.1		430	0.76
chr1_184858090_184858241	0.42	ENSG00000252222	.	67542	0.11
chr7_116141197_116141631	0.42	CAV2	caveolin 2	1580	0.29
chr15_98506044_98506195	0.41	ARRDC4	arrestin domain containing 4	2191	0.38
chr12_47219854_47220069	0.41	SLC38A4	solute carrier family 38, member 4	181	0.97
chr5_142623144_142623555	0.41	ARHGAP26	Rho GTPase activating protein 26	36584	0.19
chr1_95330057_95330663	0.41	SLC44A3	solute carrier family 44, member 3	2527	0.28
chr6_121758427_121758731	0.40	GJA1	gap junction protein, alpha 1, 43kDa	1741	0.35
chr4_39938923_39939074	0.40	ENSG00000252970	.	625	0.75
chr21_36264537_36264739	0.40	RUNX1	runt-related transcription factor 1	2551	0.42
chr7_32099128_32099768	0.40	PDE1C	phosphodiesterase 1C, calmodulin-dependent 70kDa	11013	0.32
chr9_708078_708584	0.40	KANK1	KN motif and ankyrin repeat domains 1	1442	0.47
chr8_16576311_16576462	0.40	ENSG00000264092	.	144619	0.05
chr8_37678948_37679463	0.39	GPR124	G protein-coupled receptor 124	24431	0.12
chr16_86599945_86600151	0.39	FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	809	0.48
chr19_13136767_13137028	0.39	NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	1086	0.34
chr10_12095697_12095857	0.39	UPF2	UPF2 regulator of nonsense transcripts homolog (yeast)	10754	0.17
chr17_67137246_67137397	0.39	ABCA6	ATP-binding cassette, sub-family A (ABC1), member 6	694	0.69
chr1_68697735_68698156	0.39	WLS	wntless Wnt ligand secretion mediator	18	0.98
chr18_74202036_74202284	0.39	ZNF516	zinc finger protein 516	575	0.66
chr4_87935725_87935950	0.39	AFF1	AF4/FMR2 family, member 1	7416	0.29
chr18_30563491_30563642	0.38	RP11-680N20.1		29527	0.24
chr20_10502111_10502382	0.38	SLX4IP	SLX4 interacting protein	86295	0.09
chr7_82188634_82189045	0.38	CACNA2D1	calcium channel, voltage-dependent, alpha 2/delta subunit 1	115725	0.07
chr2_36924982_36925262	0.38	VIT	vitrin	1102	0.6
chr1_119529068_119529220	0.38	TBX15	T-box 15	1284	0.57
chr5_88120627_88121096	0.37	MEF2C	myocyte enhancer factor 2C	704	0.78
chr2_64926239_64926446	0.37	SERTAD2	SERTA domain containing 2	45295	0.15
chr8_16689434_16690090	0.37	ENSG00000264092	.	31243	0.24
chr3_181434209_181434555	0.37	SOX2	SRY (sex determining region Y)-box 2	4660	0.26
chr2_200446222_200446758	0.37	SATB2	SATB homeobox 2	110501	0.07
chr4_15010597_15010748	0.37	CPEB2	cytoplasmic polyadenylation element binding protein 2	5112	0.32
chr10_119132010_119132432	0.37	PDZD8	PDZ domain containing 8	2757	0.3
chr5_88027797_88028081	0.37	CTC-467M3.2		39471	0.16
chr11_102959875_102960225	0.37	DCUN1D5	DCN1, defective in cullin neddylation 1, domain containing 5	3	0.98
chr9_80409118_80409269	0.37	GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	28722	0.25
chr18_67713592_67713743	0.37	RTTN	rotatin	25713	0.25
chr15_56206090_56206310	0.36	NEDD4	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	1652	0.45
chr3_136677766_136677917	0.36	IL20RB	interleukin 20 receptor beta	990	0.56
chr1_39860957_39861272	0.36	KIAA0754	KIAA0754	15037	0.18
chr8_70406794_70407007	0.36	SULF1	sulfatase 1	1872	0.5
chr7_123390243_123390394	0.36	RP11-390E23.6		1196	0.34
chr1_23696524_23696675	0.36	ENSG00000201405	.	148	0.82
chr12_66220556_66220804	0.36	HMGA2	high mobility group AT-hook 2	1777	0.39
chr13_39945288_39945439	0.36	ENSG00000238408	.	75990	0.12
chr2_189247602_189247926	0.36	ENSG00000207951	.	85545	0.09
chr12_78336292_78336638	0.35	NAV3	neuron navigator 3	23591	0.28
chr22_35778076_35778227	0.35	HMOX1	heme oxygenase (decycling) 1	1323	0.43
chr10_119303944_119304573	0.35	EMX2OS	EMX2 opposite strand/antisense RNA	321	0.88
chr4_61665381_61665532	0.35	ENSG00000265829	.	122881	0.06
chr6_26577102_26577344	0.35	ABT1	activator of basal transcription 1	19957	0.15
chr5_53386895_53387046	0.35	ENSG00000265421	.	15557	0.24
chr9_96902091_96902301	0.35	ENSG00000199165	.	36038	0.13
chr2_237479145_237479357	0.35	ACKR3	atypical chemokine receptor 3	967	0.68
chr1_86048991_86049142	0.35	CYR61	cysteine-rich, angiogenic inducer, 61	2622	0.26
chr2_171381865_171382027	0.35	AC007277.3		118508	0.06
chr5_139418219_139418461	0.35	NRG2	neuregulin 2	4314	0.21
chr2_12842465_12842741	0.35	TRIB2	tribbles pseudokinase 2	14412	0.26
chr3_126500993_126501380	0.35	CHCHD6	coiled-coil-helix-coiled-coil-helix domain containing 6	51779	0.16
chr22_44722319_44722530	0.35	KIAA1644	KIAA1644	13693	0.24
chr4_114388823_114389059	0.35	CAMK2D	calcium/calmodulin-dependent protein kinase II delta	46057	0.14
chr15_38548551_38548873	0.35	SPRED1	sprouty-related, EVH1 domain containing 1	3330	0.39
chr10_54202834_54203158	0.34	RP11-556E13.1		117869	0.06
chr5_61389615_61389794	0.34	ENSG00000251983	.	52788	0.18
chr21_32715523_32716836	0.34	TIAM1	T-cell lymphoma invasion and metastasis 1	415	0.91
chr6_111582018_111582254	0.34	KIAA1919	KIAA1919	1585	0.29
chr13_21388856_21389007	0.34	N6AMT2	N-6 adenine-specific DNA methyltransferase 2 (putative)	40843	0.16
chr2_98765349_98765752	0.34	VWA3B	von Willebrand factor A domain containing 3B	61851	0.13
chr14_32037334_32037518	0.34	NUBPL	nucleotide binding protein-like	6596	0.17
chr4_184040476_184040627	0.34	WWC2	WW and C2 domain containing 2	19906	0.19
chr4_114705923_114706074	0.34	CAMK2D	calcium/calmodulin-dependent protein kinase II delta	22915	0.27
chr8_107738861_107739281	0.34	OXR1	oxidation resistance 1	658	0.71
chr9_123919065_123919216	0.34	CNTRL	centriolin	981	0.55
chr12_125170011_125170375	0.33	NCOR2	nuclear receptor corepressor 2	118183	0.06
chr7_78911351_78911863	0.33	ENSG00000212482	.	61081	0.15
chr7_116222889_116223134	0.33	AC006159.4		11723	0.18
chr4_23890359_23890765	0.33	PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	1096	0.66
chr14_50692436_50692613	0.33	SOS2	son of sevenless homolog 2 (Drosophila)	5503	0.22
chr5_66254399_66254664	0.33	MAST4	microtubule associated serine/threonine kinase family member 4	167	0.97
chr14_35179773_35180008	0.33	CFL2	cofilin 2 (muscle)	3144	0.26
chr11_94503028_94503179	0.33	AMOTL1	angiomotin like 1	1566	0.45
chr4_102277312_102277561	0.33	PPP3CA	protein phosphatase 3, catalytic subunit, alpha isozyme	8001	0.2
chr14_29254002_29254283	0.33	RP11-966I7.2		851	0.56
chr2_197831476_197831662	0.33	ANKRD44	ankyrin repeat domain 44	33657	0.18
chr17_27719677_27719955	0.33	TAOK1	TAO kinase 1	1867	0.18
chr12_78334931_78335200	0.33	NAV3	neuron navigator 3	24991	0.28
chr14_79747812_79748200	0.33	NRXN3	neurexin 3	1757	0.44
chr9_97666762_97667035	0.32	RP11-49O14.2		4187	0.23
chr1_68297324_68297475	0.32	GNG12-AS1	GNG12 antisense RNA 1	587	0.71
chr21_17679599_17679750	0.32	ENSG00000201025	.	22585	0.28
chr8_32441619_32441833	0.32	NRG1	neuregulin 1	21440	0.28
chr1_71831333_71831497	0.32	ENSG00000229956	.	35990	0.23
chr4_81192022_81192173	0.32	FGF5	fibroblast growth factor 5	4304	0.29
chr2_110656312_110656910	0.32	LIMS3	LIM and senescent cell antigen-like domains 3	343	0.93
chr10_29916878_29917029	0.32	SVIL	supervillin	6948	0.21
chr12_8814882_8815352	0.32	MFAP5	microfibrillar associated protein 5	98	0.95
chr6_10409161_10409312	0.32	TFAP2A-AS1	TFAP2A antisense RNA 1	337	0.8
chr10_33665800_33666194	0.32	NRP1	neuropilin 1	40807	0.2
chr15_56205778_56205950	0.32	NEDD4	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	1988	0.4
chr7_7197772_7198055	0.32	C1GALT1	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1	1348	0.45
chr4_176692255_176692416	0.32	GPM6A	glycoprotein M6A	16203	0.23
chr15_25638050_25638201	0.32	UBE3A	ubiquitin protein ligase E3A	12528	0.11
chr14_79426395_79426572	0.32	CTD-2243E23.1		114622	0.07
chr4_54424539_54424751	0.31	LNX1	ligand of numb-protein X 1, E3 ubiquitin protein ligase	261	0.93
chr20_14316163_14316462	0.31	FLRT3	fibronectin leucine rich transmembrane protein 3	1942	0.4
chr3_151694269_151694458	0.31	RP11-454C18.2		48400	0.17
chr6_3180552_3180703	0.31	TUBB2A	tubulin, beta 2A class IIa	22867	0.13
chr20_7148010_7148161	0.31	ENSG00000251833	.	306424	0.01
chr18_56532811_56532962	0.31	ZNF532	zinc finger protein 532	100	0.97
chr2_12928938_12929131	0.31	ENSG00000264370	.	51541	0.17
chr2_109271526_109272143	0.31	LIMS1	LIM and senescent cell antigen-like domains 1	325	0.91
chr6_125684129_125684280	0.31	RP11-735G4.1		11266	0.27
chr4_170069363_170069514	0.31	RP11-327O17.2		53507	0.15

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of DRGX_PROP1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.0	GO:0050923	regulation of negative chemotaxis(GO:0050923)
0.2	0.6	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.2	0.8	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.4	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.1	0.4	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.1	0.4	GO:0010842	retina layer formation(GO:0010842)
0.1	0.2	GO:0031223	auditory behavior(GO:0031223)
0.1	0.5	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.1	0.3	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.1	0.2	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.1	0.3	GO:0048342	paraxial mesodermal cell differentiation(GO:0048342) paraxial mesodermal cell fate commitment(GO:0048343)
0.1	0.6	GO:0060347	heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.1	0.2	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.1	0.3	GO:0010665	striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.1	0.1	GO:0060435	bronchiole development(GO:0060435)
0.1	0.5	GO:0046426	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1	0.2	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.1	0.3	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.1	0.1	GO:0048520	positive regulation of behavior(GO:0048520)
0.1	0.1	GO:2000178	negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.1	0.2	GO:0071694	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.7	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.1	0.2	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1	0.2	GO:0060174	limb bud formation(GO:0060174)
0.1	0.1	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.1	0.2	GO:0008354	germ cell migration(GO:0008354)
0.1	0.3	GO:0060997	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.1	0.2	GO:0006452	translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.1	0.2	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.2	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.1	GO:0061072	iris morphogenesis(GO:0061072)
0.0	0.6	GO:0007184	SMAD protein import into nucleus(GO:0007184)
0.0	0.3	GO:1901532	regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0	0.1	GO:0032413	negative regulation of ion transmembrane transporter activity(GO:0032413)
0.0	0.2	GO:0035066	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.2	GO:0070141	response to UV-A(GO:0070141)
0.0	0.0	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0	0.0	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0032236	obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0	0.1	GO:0021563	glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0	0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.0	GO:0001743	optic placode formation(GO:0001743)
0.0	0.2	GO:0006533	aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.2	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.3	GO:0030853	negative regulation of granulocyte differentiation(GO:0030853)
0.0	0.2	GO:0042023	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.2	GO:0002052	positive regulation of neuroblast proliferation(GO:0002052)
0.0	0.2	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.2	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.2	GO:0014805	smooth muscle adaptation(GO:0014805)
0.0	0.2	GO:0022617	extracellular matrix disassembly(GO:0022617)
0.0	0.1	GO:0032823	natural killer cell differentiation(GO:0001779) regulation of natural killer cell differentiation(GO:0032823) positive regulation of natural killer cell differentiation(GO:0032825)
0.0	0.0	GO:0060841	venous blood vessel development(GO:0060841)
0.0	0.1	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.1	GO:0044415	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.1	GO:0010107	potassium ion import(GO:0010107)
0.0	0.7	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.3	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0	0.1	GO:0051940	regulation of neurotransmitter uptake(GO:0051580) regulation of dopamine uptake involved in synaptic transmission(GO:0051584) regulation of catecholamine uptake involved in synaptic transmission(GO:0051940)
0.0	0.0	GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081)
0.0	0.2	GO:0045992	negative regulation of embryonic development(GO:0045992)
0.0	0.1	GO:0051967	negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0	0.1	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.1	GO:0045617	negative regulation of keratinocyte differentiation(GO:0045617)
0.0	0.4	GO:0042745	circadian sleep/wake cycle(GO:0042745)
0.0	0.1	GO:0009822	alkaloid catabolic process(GO:0009822)
0.0	0.8	GO:0051353	positive regulation of oxidoreductase activity(GO:0051353)
0.0	0.1	GO:0032227	negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.1	GO:0060677	ureteric bud elongation(GO:0060677)
0.0	0.1	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0021898	commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0	0.1	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.1	GO:0060037	pharyngeal system development(GO:0060037)
0.0	0.2	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0	0.1	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.0	0.0	GO:0060594	mammary gland specification(GO:0060594)
0.0	0.1	GO:0006449	regulation of translational termination(GO:0006449)
0.0	0.2	GO:0060216	definitive hemopoiesis(GO:0060216)
0.0	0.1	GO:0021591	ventricular system development(GO:0021591)
0.0	0.0	GO:1901419	regulation of response to alcohol(GO:1901419)
0.0	0.2	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.2	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0	0.1	GO:0033024	mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0	0.1	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.0	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
0.0	0.1	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.1	GO:0046007	negative regulation of activated T cell proliferation(GO:0046007)
0.0	0.0	GO:0021892	cerebral cortex GABAergic interneuron differentiation(GO:0021892)
0.0	0.1	GO:0061004	pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048) pattern specification involved in metanephros development(GO:0072268)
0.0	0.1	GO:0043457	regulation of cellular respiration(GO:0043457)
0.0	0.2	GO:0002076	osteoblast development(GO:0002076)
0.0	0.1	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.1	GO:0071425	hematopoietic stem cell proliferation(GO:0071425)
0.0	0.1	GO:0033504	floor plate development(GO:0033504)
0.0	0.1	GO:0097435	extracellular fibril organization(GO:0043206) fibril organization(GO:0097435)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.1	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.1	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.1	GO:0060900	optic cup morphogenesis involved in camera-type eye development(GO:0002072) embryonic camera-type eye formation(GO:0060900)
0.0	0.2	GO:0046033	AMP metabolic process(GO:0046033)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.0	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.1	GO:0045074	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.0	GO:0060242	contact inhibition(GO:0060242)
0.0	0.3	GO:0008210	estrogen metabolic process(GO:0008210)
0.0	0.1	GO:0071157	negative regulation of cell cycle arrest(GO:0071157)
0.0	0.4	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.0	0.0	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0	0.1	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.0	GO:0070561	vitamin D receptor signaling pathway(GO:0070561)
0.0	0.1	GO:0010800	positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0	0.0	GO:0030812	negative regulation of nucleotide catabolic process(GO:0030812) negative regulation of nucleoside metabolic process(GO:0045978) negative regulation of ATP metabolic process(GO:1903579)
0.0	0.1	GO:0007216	G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0	0.1	GO:0021800	cerebral cortex tangential migration(GO:0021800)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.0	GO:0001957	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.2	GO:0000052	citrulline metabolic process(GO:0000052)
0.0	0.0	GO:0090030	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347) regulation of steroid hormone biosynthetic process(GO:0090030)
0.0	0.2	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.4	GO:0008038	neuron recognition(GO:0008038)
0.0	0.1	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.0	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.2	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.1	GO:0016322	neuron remodeling(GO:0016322)
0.0	0.1	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.1	GO:0014912	negative regulation of smooth muscle cell migration(GO:0014912)
0.0	0.1	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.3	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.3	GO:0021846	cell proliferation in forebrain(GO:0021846)
0.0	0.1	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.0	0.2	GO:0007416	synapse assembly(GO:0007416)
0.0	0.1	GO:0042866	pyruvate biosynthetic process(GO:0042866)
0.0	0.3	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.1	GO:0046322	negative regulation of fatty acid oxidation(GO:0046322)
0.0	0.0	GO:0033091	positive regulation of immature T cell proliferation(GO:0033091)
0.0	0.1	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
0.0	0.1	GO:0045618	positive regulation of keratinocyte differentiation(GO:0045618)
0.0	0.2	GO:0007567	parturition(GO:0007567)
0.0	0.1	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.0	0.0	GO:0032351	negative regulation of hormone metabolic process(GO:0032351) negative regulation of hormone biosynthetic process(GO:0032353)
0.0	0.0	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0	0.3	GO:0009954	proximal/distal pattern formation(GO:0009954)
0.0	0.0	GO:0001306	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.0	GO:0019336	phenol-containing compound catabolic process(GO:0019336) catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0	0.1	GO:0051965	positive regulation of synapse assembly(GO:0051965)
0.0	0.1	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.0	GO:0002118	aggressive behavior(GO:0002118)
0.0	0.1	GO:2000258	negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0	0.0	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0046325	negative regulation of glucose transport(GO:0010829) negative regulation of glucose import(GO:0046325)
0.0	0.0	GO:0007412	axon target recognition(GO:0007412)
0.0	0.1	GO:0051044	positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0	0.1	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.0	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.1	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:0008053	mitochondrial fusion(GO:0008053)
0.0	0.2	GO:0030299	intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.0	0.1	GO:0043438	acetoacetic acid metabolic process(GO:0043438)
0.0	0.1	GO:0001974	blood vessel remodeling(GO:0001974)
0.0	1.1	GO:0030198	extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0	0.1	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.0	GO:0060023	soft palate development(GO:0060023)
0.0	0.0	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.2	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.0	2.0	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0	0.0	GO:0046881	positive regulation of gonadotropin secretion(GO:0032278) positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0	0.1	GO:0033137	negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0	0.0	GO:0001992	regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.0	0.2	GO:0050999	regulation of nitric-oxide synthase activity(GO:0050999)
0.0	0.0	GO:0060267	positive regulation of respiratory burst(GO:0060267)
0.0	0.1	GO:0009249	protein lipoylation(GO:0009249)
0.0	0.0	GO:0030202	heparin metabolic process(GO:0030202)
0.0	0.0	GO:0014826	vein smooth muscle contraction(GO:0014826)
0.0	0.1	GO:0008218	bioluminescence(GO:0008218)
0.0	0.1	GO:0097094	cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0	0.1	GO:0045668	negative regulation of osteoblast differentiation(GO:0045668)
0.0	0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.1	GO:0090399	replicative senescence(GO:0090399)
0.0	0.0	GO:0022038	corpus callosum development(GO:0022038)
0.0	0.0	GO:0021778	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0	0.0	GO:0048539	bone marrow development(GO:0048539)
0.0	0.1	GO:0021513	spinal cord dorsal/ventral patterning(GO:0021513)
0.0	0.0	GO:0021570	rhombomere 4 development(GO:0021570)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.1	GO:0033599	regulation of mammary gland epithelial cell proliferation(GO:0033599)
0.0	0.1	GO:0046184	aldehyde biosynthetic process(GO:0046184)
0.0	0.0	GO:0061525	hindgut morphogenesis(GO:0007442) hindgut development(GO:0061525)
0.0	0.0	GO:0021930	cell proliferation in hindbrain(GO:0021534) cell proliferation in external granule layer(GO:0021924) cerebellar granule cell precursor proliferation(GO:0021930)
0.0	0.0	GO:0003211	cardiac chamber formation(GO:0003207) cardiac ventricle formation(GO:0003211)
0.0	0.0	GO:0006011	UDP-glucose metabolic process(GO:0006011)
0.0	0.0	GO:2000050	regulation of non-canonical Wnt signaling pathway(GO:2000050)
0.0	0.0	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.0	0.0	GO:0003352	regulation of cilium movement(GO:0003352) regulation of cilium beat frequency(GO:0003356) cilium movement involved in cell motility(GO:0060294) regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.0	0.0	GO:1903332	regulation of protein folding(GO:1903332)
0.0	0.2	GO:0033209	tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0	0.0	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.0	GO:0071501	SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0	0.1	GO:0006465	signal peptide processing(GO:0006465)
0.0	0.0	GO:0042753	positive regulation of circadian rhythm(GO:0042753)
0.0	0.1	GO:0009200	deoxyribonucleoside triphosphate metabolic process(GO:0009200)
0.0	0.1	GO:0048169	regulation of long-term neuronal synaptic plasticity(GO:0048169)
0.0	0.0	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.1	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.0	GO:0045747	positive regulation of Notch signaling pathway(GO:0045747)
0.0	0.0	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.0	GO:0048333	mesodermal cell differentiation(GO:0048333)
0.0	0.4	GO:0001843	neural tube closure(GO:0001843) tube closure(GO:0060606)
0.0	0.0	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.0	GO:0000089	mitotic metaphase(GO:0000089)
0.0	0.0	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	0.1	GO:0032330	regulation of chondrocyte differentiation(GO:0032330)
0.0	0.0	GO:0072110	cellular response to heparin(GO:0071504) glomerular mesangial cell proliferation(GO:0072110) regulation of glomerular mesangial cell proliferation(GO:0072124)
0.0	0.1	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.1	GO:0002040	sprouting angiogenesis(GO:0002040)
0.0	0.0	GO:0001738	morphogenesis of a polarized epithelium(GO:0001738)
0.0	0.1	GO:0043113	receptor clustering(GO:0043113)
0.0	0.0	GO:0030263	apoptotic chromosome condensation(GO:0030263)
0.0	0.1	GO:0002675	positive regulation of acute inflammatory response(GO:0002675)
0.0	0.0	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.1	GO:0060612	adipose tissue development(GO:0060612)
0.0	0.1	GO:0008347	glial cell migration(GO:0008347)
0.0	0.0	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.1	GO:0048286	lung alveolus development(GO:0048286)
0.0	0.0	GO:0046349	amino sugar biosynthetic process(GO:0046349)
0.0	0.3	GO:0046847	filopodium assembly(GO:0046847)
0.0	0.1	GO:0046716	muscle cell cellular homeostasis(GO:0046716)
0.0	0.1	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway(GO:0040036)
0.0	0.2	GO:0030520	intracellular estrogen receptor signaling pathway(GO:0030520)
0.0	0.1	GO:0015701	bicarbonate transport(GO:0015701)
0.0	0.0	GO:0033345	asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.0	0.2	GO:0051925	obsolete regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051925)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0030056	hemidesmosome(GO:0030056)
0.1	0.4	GO:0001527	microfibril(GO:0001527)
0.1	0.3	GO:0071437	invadopodium(GO:0071437)
0.1	0.3	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.1	0.2	GO:0043259	laminin-10 complex(GO:0043259)
0.1	0.2	GO:0048179	activin receptor complex(GO:0048179)
0.1	0.2	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.1	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.0	0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.3	GO:0008091	spectrin(GO:0008091)
0.0	0.2	GO:0043205	fibril(GO:0043205)
0.0	0.1	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.1	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.0	0.1	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	0.7	GO:0005811	lipid particle(GO:0005811)
0.0	0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.2	GO:0005915	zonula adherens(GO:0005915)
0.0	0.2	GO:0005587	collagen type IV trimer(GO:0005587)
0.0	0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.2	GO:0005916	fascia adherens(GO:0005916)
0.0	0.1	GO:0005606	laminin-1 complex(GO:0005606)
0.0	0.1	GO:0002142	stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0	0.3	GO:0043034	costamere(GO:0043034)
0.0	0.1	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0	0.1	GO:0045277	mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.0	0.0	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.2	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.1	GO:0031512	motile primary cilium(GO:0031512)
0.0	0.1	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0043198	dendritic shaft(GO:0043198)
0.0	0.0	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	1.0	GO:0005901	caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0	1.4	GO:0099572	postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0	0.9	GO:0005604	basement membrane(GO:0005604)
0.0	0.2	GO:0005665	DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0	0.1	GO:0030128	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.3	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	0.2	GO:0005675	holo TFIIH complex(GO:0005675)
0.0	0.1	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.0	GO:0070852	cell body fiber(GO:0070852)
0.0	0.3	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.0	GO:0005787	signal peptidase complex(GO:0005787)
0.0	0.8	GO:0030426	growth cone(GO:0030426)
0.0	0.0	GO:0030673	axolemma(GO:0030673)
0.0	0.3	GO:0005640	nuclear outer membrane(GO:0005640)
0.0	0.0	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.1	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	2.2	GO:0005911	cell-cell junction(GO:0005911)
0.0	0.0	GO:0030669	clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0	0.0	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.0	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.1	GO:0071565	nBAF complex(GO:0071565)
0.0	0.0	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.9	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.2	0.5	GO:0050544	arachidonic acid binding(GO:0050544)
0.2	0.5	GO:0000987	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.2	1.0	GO:0008046	axon guidance receptor activity(GO:0008046)
0.1	0.4	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.1	0.4	GO:0045499	chemorepellent activity(GO:0045499)
0.1	0.6	GO:0005499	vitamin D binding(GO:0005499)
0.1	0.3	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.5	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.1	0.2	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.1	0.3	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1	0.2	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.1	0.3	GO:0050815	phosphoserine binding(GO:0050815)
0.1	0.3	GO:0017154	semaphorin receptor activity(GO:0017154)
0.1	0.7	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.1	0.2	GO:0030215	semaphorin receptor binding(GO:0030215)
0.1	0.3	GO:0042805	actinin binding(GO:0042805)
0.1	0.2	GO:0050682	AF-2 domain binding(GO:0050682)
0.1	0.2	GO:0016842	amidine-lyase activity(GO:0016842)
0.1	0.2	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.4	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.1	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.2	GO:0016933	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.2	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.3	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.5	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.2	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.4	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.2	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0	0.1	GO:0050897	cobalt ion binding(GO:0050897)
0.0	0.2	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.1	GO:0035198	miRNA binding(GO:0035198)
0.0	0.1	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.1	GO:0016886	ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0	0.1	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.1	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.4	GO:0031490	chromatin DNA binding(GO:0031490)
0.0	0.1	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.9	GO:0030145	manganese ion binding(GO:0030145)
0.0	0.3	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.1	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.1	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)
0.0	0.5	GO:0045296	cadherin binding(GO:0045296)
0.0	0.3	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.2	GO:0000982	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0	0.2	GO:0004630	phospholipase D activity(GO:0004630)
0.0	0.2	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.2	GO:0050780	dopamine receptor binding(GO:0050780)
0.0	0.7	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.0	0.2	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0	0.1	GO:0030172	troponin C binding(GO:0030172)
0.0	0.1	GO:0019797	procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0	0.2	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.1	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.1	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.3	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.0	0.0	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.2	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0004466	long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.0	0.1	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0	0.3	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	0.3	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	1.8	GO:0008201	heparin binding(GO:0008201)
0.0	0.1	GO:0003701	obsolete RNA polymerase I transcription factor activity(GO:0003701)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.2	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.0	GO:0032554	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.1	GO:0047429	nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0	0.2	GO:0070717	poly-purine tract binding(GO:0070717)
0.0	0.1	GO:0000403	Y-form DNA binding(GO:0000403)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.2	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.1	GO:0055103	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.1	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.1	GO:0004622	lysophospholipase activity(GO:0004622)
0.0	0.0	GO:0052834	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.0	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.1	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.4	GO:0001076	transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.0	0.2	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0	0.1	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.1	GO:0005148	prolactin receptor binding(GO:0005148)
0.0	0.1	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	0.2	GO:0035254	glutamate receptor binding(GO:0035254)
0.0	0.9	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.0	GO:0061505	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.2	GO:0005355	glucose transmembrane transporter activity(GO:0005355)
0.0	0.0	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.0	GO:0016453	C-acetyltransferase activity(GO:0016453)
0.0	0.1	GO:0019841	retinol binding(GO:0019841)
0.0	0.1	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.1	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.0	0.1	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.0	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.0	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.0	GO:0070815	peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.0	0.1	GO:0005109	frizzled binding(GO:0005109)
0.0	0.1	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.1	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0	0.0	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.0	GO:0034186	apolipoprotein A-I binding(GO:0034186)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.0	0.5	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.3	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.0	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	0.1	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	0.3	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	0.4	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	0.5	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.6	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	0.6	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	1.1	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	1.1	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.0	0.1	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	0.1	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	0.4	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.0	0.7	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling
0.0	0.6	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	0.6	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	0.1	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events
0.0	0.2	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	0.3	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.0	0.3	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
0.0	0.1	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	0.0	PID ALK2 PATHWAY	ALK2 signaling events
0.0	0.2	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.0	0.2	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	0.4	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0	0.1	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.4	PID HNF3A PATHWAY	FOXA1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
0.1	0.9	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.1	1.1	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.1	0.2	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.0	1.2	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.4	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.3	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.3	REACTOME OPIOID SIGNALLING	Genes involved in Opioid Signalling
0.0	0.5	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.2	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.6	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	0.3	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.5	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.0	0.5	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.0	0.4	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	0.2	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.0	0.9	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.3	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels
0.0	0.2	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.6	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.0	0.2	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.0	0.0	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.3	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.4	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	0.1	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.3	REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0	0.1	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.0	0.0	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.0	0.2	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.2	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.0	0.4	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.0	0.1	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.0	0.3	REACTOME ADP SIGNALLING THROUGH P2RY1	Genes involved in ADP signalling through P2Y purinoceptor 1
0.0	0.5	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.0	0.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)