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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for E2F2_E2F5

Z-value: 0.82

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Transcription factors associated with E2F2_E2F5

Gene Symbol	Gene ID	Gene Info
E2F2 Ensembl NCBI GeneCards UniProt	ENSG00000007968.6	E2F2
E2F5 Ensembl NCBI GeneCards UniProt	ENSG00000133740.6	E2F5

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
E2F2	chr1_23854853_23855052	2760	0.249146	0.70	3.6e-02	Click!
E2F2	chr1_23857954_23858302	416	0.833272	0.70	3.6e-02	Click!
E2F2	chr1_23866506_23866674	8878	0.175383	0.69	3.8e-02	Click!
E2F2	chr1_23856502_23856679	1122	0.484736	0.62	7.6e-02	Click!
E2F2	chr1_23866282_23866470	8664	0.176025	0.61	8.1e-02	Click!
E2F5	chr8_86112985_86113136	5338	0.140923	-0.44	2.4e-01	Click!
E2F5	chr8_86089338_86089536	23	0.624274	0.41	2.7e-01	Click!

Activity of the E2F2_E2F5 motif across conditions

Conditions sorted by the z-value of the E2F2_E2F5 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr13_46755525_46755771	0.51	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	811	0.58
chr5_130883505_130884015	0.37	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	15034	0.29
chr1_184723746_184723985	0.35	EDEM3	ER degradation enhancer, mannosidase alpha-like 3	164	0.96
chr6_27833013_27833577	0.30	HIST1H2AL	histone cluster 1, H2al	261	0.76
chr4_89884993_89885181	0.30	FAM13A	family with sequence similarity 13, member A	65964	0.13
chr18_19279350_19279501	0.29	ABHD3	abhydrolase domain containing 3	4224	0.13
chr12_122984366_122984751	0.28	ZCCHC8	zinc finger, CCHC domain containing 8	237	0.91
chr3_119396008_119396222	0.27	COX17	COX17 cytochrome c oxidase copper chaperone	78	0.97
chr10_43951098_43951286	0.27	ENSG00000252532	.	2321	0.26
chr4_83812571_83812986	0.27	SEC31A	SEC31 homolog A (S. cerevisiae)	359	0.84
chr2_136634130_136634399	0.27	MCM6	minichromosome maintenance complex component 6	268	0.91
chr2_128174025_128174278	0.27	PROC	protein C (inactivator of coagulation factors Va and VIIIa)	1852	0.28
chr19_10305607_10305758	0.26	DNMT1	DNA (cytosine-5-)-methyltransferase 1	73	0.95
chr10_12306595_12306746	0.26	ENSG00000265824	.	3000	0.21
chr16_56743265_56743416	0.26	RP11-343H19.1		20540	0.08
chr12_12877828_12878109	0.26	APOLD1	apolipoprotein L domain containing 1	897	0.38
chr17_80273991_80274142	0.25	CD7	CD7 molecule	1362	0.29
chr3_50487862_50488065	0.25	ENSG00000202322	.	30751	0.11
chr6_42858682_42858971	0.25	C6orf226	chromosome 6 open reading frame 226	272	0.86
chr5_14582511_14582672	0.25	FAM105A	family with sequence similarity 105, member A	707	0.77
chr1_23885059_23885312	0.25	ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	1100	0.5
chr5_39074216_39074429	0.25	RICTOR	RPTOR independent companion of MTOR, complex 2	169	0.97
chrX_39966948_39967099	0.24	BCOR	BCL6 corepressor	10367	0.31
chr1_205290578_205290810	0.24	NUAK2	NUAK family, SNF1-like kinase, 2	189	0.94
chr11_44748747_44748903	0.24	TSPAN18	tetraspanin 18	101	0.98
chr19_37019294_37019507	0.24	ZNF260	zinc finger protein 260	162	0.51
chr14_51706549_51708116	0.24	TMX1	thioredoxin-related transmembrane protein 1	446	0.81
chrX_73164212_73165045	0.24	RP13-216E22.5		24692	0.23
chr3_37035014_37035258	0.23	MLH1	mutL homolog 1	72	0.81
chr3_85442393_85442544	0.23	ENSG00000264084	.	7608	0.34
chr2_677225_677432	0.23	TMEM18	transmembrane protein 18	111	0.54
chr17_80709945_80710208	0.23	TBCD	tubulin folding cofactor D	42	0.95
chr17_78120589_78120769	0.23	EIF4A3	eukaryotic translation initiation factor 4A3	259	0.9
chr3_14989325_14989581	0.23	FGD5-AS1	FGD5 antisense RNA 1	53	0.72
chrX_119619280_119620483	0.23	LAMP2	lysosomal-associated membrane protein 2	16661	0.2
chr20_20693389_20693558	0.22	RALGAPA2	Ral GTPase activating protein, alpha subunit 2 (catalytic)	342	0.92
chr19_50354007_50354329	0.22	PTOV1	prostate tumor overexpressed 1	30	0.62
chr19_1438420_1438608	0.22	RPS15	ribosomal protein S15	95	0.9
chr13_34392298_34392510	0.22	RFC3	replication factor C (activator 1) 3, 38kDa	198	0.96
chrX_102531488_102531657	0.22	TCEAL5	transcription elongation factor A (SII)-like 5	228	0.92
chr17_58678123_58678617	0.22	PPM1D	protein phosphatase, Mg2+/Mn2+ dependent, 1D	826	0.61
chr16_10837539_10837690	0.21	NUBP1	nucleotide binding protein 1	29	0.98
chrY_15815919_15816489	0.21	TMSB4Y	thymosin beta 4, Y-linked	757	0.72
chr3_42814035_42814186	0.21	CCDC13	coiled-coil domain containing 13	635	0.55
chr4_129731266_129731814	0.21	JADE1	jade family PHD finger 1	354	0.92
chr8_90995843_90996298	0.21	NBN	nibrin	395	0.87
chr21_46824152_46824303	0.21	COL18A1	collagen, type XVIII, alpha 1	825	0.56
chr21_34697352_34697672	0.21	IFNAR1	interferon (alpha, beta and omega) receptor 1	234	0.93
chr5_42952303_42952454	0.21	SEPP1	selenoprotein P, plasma, 1	64884	0.09
chr20_2082221_2082677	0.21	STK35	serine/threonine kinase 35	79	0.98
chr12_14518654_14518864	0.20	ATF7IP	activating transcription factor 7 interacting protein	96	0.98
chr11_46721727_46722111	0.20	ARHGAP1	Rho GTPase activating protein 1	230	0.69
chr5_70196845_70197188	0.20	SERF1A	small EDRK-rich factor 1A (telomeric)	195	0.96
chr17_66288424_66288865	0.20	ARSG	arylsulfatase G	985	0.41
chr7_101459208_101459407	0.20	CUX1	cut-like homeobox 1	6	0.98
chr3_31573575_31573846	0.20	STT3B	STT3B, subunit of the oligosaccharyltransferase complex (catalytic)	572	0.85
chr19_56146129_56146280	0.20	ZNF580	zinc finger protein 580	178	0.77
chr19_17622493_17622725	0.20	PGLS	6-phosphogluconolactonase	65	0.94
chr6_26233316_26233497	0.20	HIST1H1D	histone cluster 1, H1d	1810	0.12
chr1_63249822_63250184	0.19	ATG4C	autophagy related 4C, cysteine peptidase	197	0.96
chr1_222988010_222988273	0.19	DISP1	dispatched homolog 1 (Drosophila)	57472	0.11
chr6_27775872_27776194	0.19	HIST1H2AI	histone cluster 1, H2ai	134	0.69
chr7_100034295_100034484	0.19	PPP1R35	protein phosphatase 1, regulatory subunit 35	201	0.72
chr22_31615175_31615326	0.19	ENSG00000199695	.	3589	0.13
chr17_73975299_73975497	0.19	TEN1	TEN1 CST complex subunit	46	0.49
chr3_142838592_142838743	0.18	CHST2	carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2	494	0.84
chr16_84681720_84681934	0.18	KLHL36	kelch-like family member 36	304	0.9
chr14_22961814_22961965	0.18	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	5718	0.11
chr7_30634096_30634338	0.18	GARS	glycyl-tRNA synthetase	80	0.61
chr15_57211218_57211369	0.18	TCF12	transcription factor 12	53	0.9
chr9_98080006_98080370	0.18	FANCC	Fanconi anemia, complementation group C	204	0.96
chr10_99051898_99052365	0.18	ARHGAP19-SLIT1	ARHGAP19-SLIT1 readthrough (NMD candidate)	253	0.48
chr14_97879221_97879798	0.18	ENSG00000240730	.	117001	0.07
chr6_52149357_52149559	0.17	MCM3	minichromosome maintenance complex component 3	47	0.98
chr6_31619842_31620065	0.17	BAG6	BCL2-associated athanogene 6	18	0.71
chr1_149982780_149982931	0.17	OTUD7B	OTU domain containing 7B	230	0.91
chr2_160569063_160569519	0.17	MARCH7	membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase	273	0.94
chr7_7679470_7679820	0.17	RPA3	replication protein A3, 14kDa	12	0.99
chr1_12201087_12201238	0.17	TNFRSF8	tumor necrosis factor receptor superfamily, member 8	15206	0.15
chr1_23857954_23858302	0.17	E2F2	E2F transcription factor 2	416	0.83
chr6_142467968_142468269	0.17	VTA1	vesicle (multivesicular body) trafficking 1	249	0.93
chr6_36164322_36164500	0.17	BRPF3	bromodomain and PHD finger containing, 3	110	0.88
chr15_41952602_41953001	0.17	MGA	MGA, MAX dimerization protein	191	0.94
chr17_10600647_10600878	0.17	SCO1	SCO1 cytochrome c oxidase assembly protein	85	0.59
chrX_123095829_123096146	0.17	STAG2	stromal antigen 2	43	0.98
chr5_69321431_69321977	0.17	SERF1B	small EDRK-rich factor 1B (centromeric)	343	0.9
chr15_34634257_34634507	0.17	NOP10	NOP10 ribonucleoprotein	942	0.33
chr2_242625574_242625851	0.17	DTYMK	deoxythymidylate kinase (thymidylate kinase)	415	0.72
chr8_38854817_38854968	0.17	ADAM9	ADAM metallopeptidase domain 9	387	0.57
chr11_12132484_12132785	0.17	MICAL2	microtubule associated monooxygenase, calponin and LIM domain containing 2	496	0.87
chr19_45418370_45418582	0.17	APOC1	apolipoprotein C-I	350	0.72
chr8_18973333_18973484	0.16	PSD3	pleckstrin and Sec7 domain containing 3	31168	0.23
chr21_38630680_38631091	0.16	DSCR3	Down syndrome critical region gene 3	8738	0.17
chr21_44582259_44582410	0.16	AP001631.10		53	0.97
chr19_1407342_1407493	0.16	DAZAP1	DAZ associated protein 1	151	0.88
chr10_63809082_63810748	0.16	ARID5B	AT rich interactive domain 5B (MRF1-like)	945	0.69
chr8_71971447_71971598	0.16	RP11-326E22.1		96170	0.09
chr3_105088175_105088464	0.16	ALCAM	activated leukocyte cell adhesion molecule	2132	0.49
chrX_40027620_40027771	0.16	BCOR	BCL6 corepressor	8878	0.31
chr13_108870830_108871120	0.16	ABHD13	abhydrolase domain containing 13	248	0.5
chr17_44344409_44344766	0.16	RP11-259G18.1		191	0.93
chr19_46144786_46145014	0.16	C19orf83	chromosome 19 open reading frame 83	49	0.91
chr19_11616618_11616769	0.15	ZNF653	zinc finger protein 653	45	0.95
chr1_120612553_120612848	0.15	NOTCH2	notch 2	460	0.87
chr1_235247521_235247672	0.15	ENSG00000207181	.	43656	0.13
chr14_60982037_60982188	0.15	C14orf39	chromosome 14 open reading frame 39	149	0.67
chr10_7449615_7449918	0.15	SFMBT2	Scm-like with four mbt domains 2	941	0.7
chr13_45694691_45695194	0.15	GTF2F2	general transcription factor IIF, polypeptide 2, 30kDa	292	0.87
chr5_178053297_178053654	0.15	CLK4	CDC-like kinase 4	556	0.76
chr3_69100609_69100945	0.15	TMF1	TATA element modulatory factor 1	677	0.58
chr19_16295903_16296067	0.15	FAM32A	family with sequence similarity 32, member A	206	0.9
chr12_2986635_2986949	0.15	RHNO1	RAD9-HUS1-RAD1 interacting nuclear orphan 1	403	0.54
chr12_31811913_31812109	0.15	METTL20	methyltransferase like 20	110	0.96
chr1_28574021_28574215	0.15	RP5-1092A3.4		6154	0.12
chr19_633126_633363	0.15	POLRMT	polymerase (RNA) mitochondrial (DNA directed)	353	0.74
chr14_81687775_81688125	0.15	GTF2A1	general transcription factor IIA, 1, 19/37kDa	375	0.88
chr5_74062328_74062877	0.15	NSA2	NSA2 ribosome biogenesis homolog (S. cerevisiae)	215	0.57
chr6_32098148_32098328	0.15	FKBPL	FK506 binding protein like	170	0.87
chr5_43064729_43065087	0.15	CTD-2201E18.3		2613	0.21
chr4_100870352_100870894	0.15	RP11-15B17.1		540	0.59
chr2_175350503_175351393	0.15	GPR155	G protein-coupled receptor 155	817	0.65
chr4_1161098_1161472	0.15	RP11-20I20.4		281	0.86
chr10_22904775_22905136	0.15	PIP4K2A	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	24313	0.26
chr6_3229020_3229250	0.15	TUBB2B	tubulin, beta 2B class IIb	1166	0.44
chr17_4607485_4607753	0.14	PELP1	proline, glutamate and leucine rich protein 1	1	0.56
chr1_36234823_36235223	0.14	CLSPN	claspin	506	0.76
chr8_23021171_23021491	0.14	TNFRSF10D	tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain	212	0.91
chr8_22551556_22552015	0.14	EGR3	early growth response 3	970	0.44
chr15_44719862_44720599	0.14	CTDSPL2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2	218	0.85
chr15_41047576_41047750	0.14	RMDN3	regulator of microtubule dynamics 3	129	0.93
chr5_180649554_180650164	0.14	ENSG00000264732	.	226	0.59
chr4_39045572_39046195	0.14	KLHL5	kelch-like family member 5	776	0.67
chr4_84376358_84376962	0.14	HELQ	helicase, POLQ-like	316	0.61
chr7_39991401_39992022	0.14	CDK13	cyclin-dependent kinase 13	1602	0.37
chr11_34937157_34937669	0.14	PDHX	pyruvate dehydrogenase complex, component X	37	0.89
chr5_132083512_132083663	0.14	CCNI2	cyclin I family, member 2	450	0.75
chr2_173293363_173293761	0.14	AC078883.4		231	0.88
chr11_22215104_22215474	0.14	ANO5	anoctamin 5	567	0.84
chr9_139433380_139433586	0.14	RP11-413M3.4		3850	0.11
chr20_18269271_18269509	0.14	ZNF133	zinc finger protein 133	212	0.9
chr3_197476356_197476565	0.14	FYTTD1	forty-two-three domain containing 1	36	0.58
chrX_45709671_45710004	0.14	ENSG00000212347	.	42577	0.19
chr11_77850351_77850689	0.14	ALG8	ALG8, alpha-1,3-glucosyltransferase	118	0.72
chr6_27099516_27099912	0.14	HIST1H2BJ	histone cluster 1, H2bj	613	0.5
chr9_99180680_99180947	0.14	ZNF367	zinc finger protein 367	202	0.95
chr11_121322497_121322843	0.14	SORL1	sortilin-related receptor, L(DLR class) A repeats containing	242	0.88
chr6_82460724_82461189	0.14	FAM46A	family with sequence similarity 46, member A	514	0.8
chr9_134152676_134153362	0.13	FAM78A	family with sequence similarity 78, member A	1085	0.5
chr14_55877782_55878514	0.13	ATG14	autophagy related 14	428	0.86
chrY_15863423_15864046	0.13	KALP	Kallmann syndrome sequence pseudogene	198	0.96
chr5_169064267_169064974	0.13	DOCK2	dedicator of cytokinesis 2	369	0.91
chr6_84568793_84569179	0.13	CYB5R4	cytochrome b5 reductase 4	376	0.89
chr5_79553424_79553684	0.13	SERINC5	serine incorporator 5	1656	0.36
chr11_62622072_62622332	0.13	ENSG00000255717	.	35	0.92
chr12_83080910_83081086	0.13	TMTC2	transmembrane and tetratricopeptide repeat containing 2	218	0.97
chr12_27398115_27398400	0.13	STK38L	serine/threonine kinase 38 like	333	0.92
chr9_27529480_27529683	0.13	MOB3B	MOB kinase activator 3B	198	0.95
chr21_34914612_34915092	0.13	SON	SON DNA binding protein	72	0.65
chr16_29816076_29816359	0.13	MAZ	MYC-associated zinc finger protein (purine-binding transcription factor)	1210	0.2
chr17_56565203_56565440	0.13	HSF5	heat shock transcription factor family member 5	424	0.77
chr3_187461693_187462048	0.13	BCL6	B-cell CLL/lymphoma 6	1645	0.42
chr5_134094069_134094276	0.13	DDX46	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	299	0.88
chr5_131628993_131629263	0.13	SLC22A4	solute carrier family 22 (organic cation/zwitterion transporter), member 4	1008	0.42
chr8_73921692_73921901	0.13	TERF1	telomeric repeat binding factor (NIMA-interacting) 1	684	0.67
chr19_3812640_3812791	0.13	MATK	megakaryocyte-associated tyrosine kinase	10588	0.11
chr14_60716102_60716311	0.13	PPM1A	protein phosphatase, Mg2+/Mn2+ dependent, 1A	47	0.94
chr9_70402575_70402838	0.13	IGKV1OR-3	immunoglobulin kappa variable 1/OR-3 (pseudogene)	7616	0.24
chr15_43414561_43415376	0.13	TMEM62	transmembrane protein 62	509	0.77
chr18_11850148_11850299	0.13	CHMP1B	charged multivesicular body protein 1B	1172	0.34
chr6_99281230_99281408	0.13	POU3F2	POU class 3 homeobox 2	1261	0.63
chr13_49105975_49106823	0.13	RCBTB2	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2	814	0.75
chrX_106871756_106872595	0.13	PRPS1	phosphoribosyl pyrophosphate synthetase 1	382	0.9
chr13_49821689_49822053	0.13	CDADC1	cytidine and dCMP deaminase domain containing 1	176	0.96
chr12_57481229_57481548	0.12	NAB2	NGFI-A binding protein 2 (EGR1 binding protein 2)	1289	0.28
chr1_231377063_231377587	0.12	GNPAT	glyceronephosphate O-acyltransferase	363	0.5
chr10_85954746_85954956	0.12	CDHR1	cadherin-related family member 1	437	0.79
chr2_109336300_109336755	0.12	RANBP2	RAN binding protein 2	590	0.78
chr20_25387997_25388359	0.12	GINS1	GINS complex subunit 1 (Psf1 homolog)	185	0.95
chr6_150039328_150039894	0.12	LATS1	large tumor suppressor kinase 1	219	0.92
chr5_72251895_72252188	0.12	FCHO2	FCH domain only 2	143	0.97
chr1_154934578_154934948	0.12	PYGO2	pygopus family PHD finger 2	251	0.62
chr20_23028362_23028696	0.12	THBD	thrombomodulin	1849	0.28
chr17_6938780_6939115	0.12	SLC16A13	solute carrier family 16, member 13	447	0.6
chr12_49783044_49783195	0.12	SPATS2	spermatogenesis associated, serine-rich 2	21789	0.13
chr11_129242275_129242426	0.12	BARX2	BARX homeobox 2	3485	0.36
chr11_65190939_65191303	0.12	ENSG00000245532	.	20808	0.1
chr1_54872617_54872800	0.12	SSBP3	single stranded DNA binding protein 3	616	0.78
chr1_201562555_201562715	0.12	AC096677.1	Uncharacterized protein ENSP00000471857	29378	0.14
chr2_85107193_85107344	0.12	TRABD2A	TraB domain containing 2A	938	0.57
chr3_45729758_45730513	0.12	LIMD1-AS1	LIMD1 antisense RNA 1	239	0.78
chr1_205180919_205181105	0.12	DSTYK	dual serine/threonine and tyrosine protein kinase	285	0.9
chr7_19748667_19748818	0.12	TWISTNB	TWIST neighbor	32	0.98
chr5_112315292_112315678	0.12	DCP2	decapping mRNA 2	3006	0.27
chr11_67188360_67188666	0.12	PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	139	0.88
chr1_28241326_28241544	0.12	RPA2	replication protein A2, 32kDa	178	0.92
chr10_70320968_70321193	0.12	TET1	tet methylcytosine dioxygenase 1	667	0.7
chr1_151118477_151118817	0.12	SEMA6C	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	286	0.8
chr6_106968131_106968391	0.12	AIM1	absent in melanoma 1	8531	0.21
chr22_38901190_38901707	0.12	DDX17	DEAD (Asp-Glu-Ala-Asp) box helicase 17	869	0.54
chr1_3568811_3568962	0.11	TP73	tumor protein p73	198	0.72

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F2_E2F5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.1	0.2	GO:0071428	rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.1	0.3	GO:0000730	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.2	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.1	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.2	GO:0000019	regulation of mitotic recombination(GO:0000019)
0.0	0.2	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.2	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.0	0.2	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.1	GO:0071816	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.2	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.2	GO:0042023	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.1	GO:0046940	nucleoside monophosphate phosphorylation(GO:0046940)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.1	GO:0001766	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.2	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.1	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.2	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.0	0.2	GO:0046504	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.1	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0	0.2	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.2	GO:0051103	DNA ligation involved in DNA repair(GO:0051103)
0.0	0.1	GO:0097709	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0	0.1	GO:0044818	mitotic DNA replication checkpoint(GO:0033314) mitotic G2/M transition checkpoint(GO:0044818)
0.0	0.1	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.1	GO:0001833	inner cell mass cell proliferation(GO:0001833)
0.0	0.1	GO:2000104	negative regulation of DNA-dependent DNA replication(GO:2000104)
0.0	0.1	GO:0010614	negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0	0.1	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.4	GO:0006825	copper ion transport(GO:0006825)
0.0	0.1	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.2	GO:0048207	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0	0.7	GO:0006271	DNA strand elongation involved in DNA replication(GO:0006271)
0.0	0.1	GO:0045074	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.1	GO:0051571	positive regulation of histone H3-K4 methylation(GO:0051571)
0.0	0.1	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.1	GO:0006266	DNA ligation(GO:0006266)
0.0	0.1	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.2	GO:0016226	iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0	0.0	GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0	0.2	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.0	0.1	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.1	GO:1901984	negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0	0.1	GO:0070602	centromeric sister chromatid cohesion(GO:0070601) regulation of centromeric sister chromatid cohesion(GO:0070602)
0.0	0.1	GO:0001675	acrosome assembly(GO:0001675)
0.0	0.0	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.1	GO:0006020	inositol metabolic process(GO:0006020)
0.0	0.0	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
0.0	0.1	GO:0080111	DNA demethylation(GO:0080111)
0.0	0.1	GO:0045793	positive regulation of cell size(GO:0045793)
0.0	0.2	GO:0045351	type I interferon biosynthetic process(GO:0045351)
0.0	0.0	GO:0060057	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0	0.1	GO:0060766	negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0	0.0	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.0	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.0	GO:0051569	regulation of histone H3-K4 methylation(GO:0051569)
0.0	0.0	GO:0008049	male courtship behavior(GO:0008049)
0.0	0.0	GO:0042637	catagen(GO:0042637)
0.0	0.2	GO:0000045	autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0	0.3	GO:0002286	T cell activation involved in immune response(GO:0002286)
0.0	0.0	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.4	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0	0.0	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0	0.1	GO:0006744	ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744)
0.0	0.1	GO:0006451	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0	0.0	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.0	0.1	GO:0007035	vacuolar acidification(GO:0007035)
0.0	0.2	GO:0006086	acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0	0.0	GO:0072216	positive regulation of metanephros development(GO:0072216)
0.0	0.0	GO:0045943	positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0	0.0	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0	0.0	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.0	GO:0002713	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.0	GO:0034445	plasma lipoprotein particle oxidation(GO:0034441) regulation of lipoprotein oxidation(GO:0034442) negative regulation of lipoprotein oxidation(GO:0034443) regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445) lipoprotein modification(GO:0042160) lipoprotein oxidation(GO:0042161)
0.0	0.0	GO:0008298	intracellular mRNA localization(GO:0008298)
0.0	0.1	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.0	GO:0060586	multicellular organismal iron ion homeostasis(GO:0060586)
0.0	0.0	GO:0007100	mitotic centrosome separation(GO:0007100)
0.0	0.0	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.1	GO:0015781	pyrimidine nucleotide-sugar transport(GO:0015781)
0.0	0.0	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.2	GO:0090630	activation of GTPase activity(GO:0090630)
0.0	0.1	GO:0006547	histidine metabolic process(GO:0006547)
0.0	0.0	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0	0.1	GO:0008634	obsolete negative regulation of survival gene product expression(GO:0008634)
0.0	0.1	GO:0003310	pancreatic A cell differentiation(GO:0003310)
0.0	0.0	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	0.0	GO:0018206	peptidyl-methionine modification(GO:0018206)
0.0	0.0	GO:0010511	regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0	0.1	GO:0010507	negative regulation of autophagy(GO:0010507)
0.0	0.0	GO:0002874	regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0	0.1	GO:0007220	Notch receptor processing(GO:0007220)
0.0	0.0	GO:0007000	nucleolus organization(GO:0007000)
0.0	0.1	GO:0030903	notochord development(GO:0030903)
0.0	0.0	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.1	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0	0.0	GO:0051409	response to nitrosative stress(GO:0051409)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.4	GO:0042555	MCM complex(GO:0042555)
0.0	0.2	GO:0042405	nuclear inclusion body(GO:0042405)
0.0	0.3	GO:0005662	DNA replication factor A complex(GO:0005662)
0.0	0.1	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.2	GO:0005663	DNA replication factor C complex(GO:0005663)
0.0	0.3	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.2	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.1	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.2	GO:0032389	MutLalpha complex(GO:0032389)
0.0	0.1	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.0	0.1	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0	0.2	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.2	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.0	GO:0005686	U2 snRNP(GO:0005686)
0.0	0.0	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.4	GO:0071339	MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0	0.1	GO:0000124	SAGA complex(GO:0000124)
0.0	0.2	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.0	GO:0070062	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.1	GO:0016442	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0	0.1	GO:0005682	U5 snRNP(GO:0005682)
0.0	0.1	GO:0000109	nucleotide-excision repair complex(GO:0000109)
0.0	0.2	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.1	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.0	0.0	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.0	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.0	0.0	GO:0045298	tubulin complex(GO:0045298)
0.0	0.8	GO:0071013	catalytic step 2 spliceosome(GO:0071013)
0.0	0.1	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0	0.7	GO:0000786	nucleosome(GO:0000786)
0.0	0.1	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.4	GO:1903293	protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0	0.0	GO:0030904	retromer complex(GO:0030904)
0.0	0.1	GO:0000782	telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0	0.4	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.0	0.1	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.0	GO:0001739	sex chromatin(GO:0001739)
0.0	0.2	GO:0005796	Golgi lumen(GO:0005796)
0.0	0.0	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0030992	intraciliary transport particle B(GO:0030992)
0.0	0.3	GO:0031907	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0016531	copper chaperone activity(GO:0016531)
0.0	0.2	GO:0032137	guanine/thymine mispair binding(GO:0032137)
0.0	0.2	GO:0003689	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0	0.3	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0003910	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.2	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.1	GO:0000033	alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0	0.2	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.2	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.1	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0	0.3	GO:0008143	poly(A) binding(GO:0008143)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.2	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0001517	N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0	0.1	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0	0.5	GO:0016251	obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.1	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.1	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.2	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.1	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.1	GO:0015226	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0	0.1	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	0.2	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	0.5	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.0	0.2	GO:0016565	obsolete general transcriptional repressor activity(GO:0016565)
0.0	0.0	GO:0000404	heteroduplex DNA loop binding(GO:0000404)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0070628	proteasome binding(GO:0070628)
0.0	0.0	GO:0031628	opioid receptor binding(GO:0031628)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.3	GO:0048487	beta-tubulin binding(GO:0048487)
0.0	0.0	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.0	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.0	GO:0031127	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	0.6	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.0	0.0	GO:0008192	RNA guanylyltransferase activity(GO:0008192)
0.0	0.1	GO:0030169	low-density lipoprotein particle binding(GO:0030169)
0.0	0.1	GO:0016413	O-acetyltransferase activity(GO:0016413)
0.0	0.0	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.0	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.2	GO:0005527	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.0	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.6	PID BARD1 PATHWAY	BARD1 signaling events
0.2	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.5	PID ATR PATHWAY	ATR signaling pathway
0.0	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.1	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.3	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.2	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.4	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.5	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.6	REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER	Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0	REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL	Genes involved in Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
0.3	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.4	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.4	REACTOME DOUBLE STRAND BREAK REPAIR	Genes involved in Double-Strand Break Repair
0.3	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.1	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.1	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.3	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.3	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.2	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.2	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.2	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.2	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.6	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.0	REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.4	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.1	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.2	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.3	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.1	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.2	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.1	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.4	REACTOME MRNA SPLICING MINOR PATHWAY	Genes involved in mRNA Splicing - Minor Pathway