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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for EGR1_EGR4

Z-value: 0.95

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Transcription factors associated with EGR1_EGR4

Gene Symbol Gene ID Gene Info
EGR1
ENSG00000120738.7 early growth response 1
EGR4
ENSG00000135625.6 early growth response 4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr5_137802391_137802557EGR112950.4124830.751.9e-02Click!
chr5_137802209_137802360EGR111050.4704780.732.6e-02Click!
chr5_137805025_137805176EGR139210.1994440.674.8e-02Click!
chr5_137803301_137803461EGR122020.2705670.627.5e-02Click!
chr5_137801989_137802208EGR19190.5434030.599.6e-02Click!
chr2_73518392_73518872EGR421970.2341600.541.4e-01Click!
chr2_73520179_73521065EGR42070.9171320.472.1e-01Click!
chr2_73521076_73521227EGR43180.8551920.314.1e-01Click!
chr2_73519153_73519304EGR416010.303270-0.186.5e-01Click!

Activity of the EGR1_EGR4 motif across conditions

Conditions sorted by the z-value of the EGR1_EGR4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr9_133308330_133308718 0.57 HMCN2
 hemicentin 2
 2855
 0.21
chr14_75077508_75077674 0.54 LTBP2
 latent transforming growth factor beta binding protein 2
 1184
 0.5
chr3_55514769_55515136 0.45 WNT5A
 wingless-type MMTV integration site family, member 5A
 272
 0.94
chr9_124480535_124480686 0.45 DAB2IP
 DAB2 interacting protein
 18961
 0.24
chr17_62051691_62051850 0.41 SCN4A
 sodium channel, voltage-gated, type IV, alpha subunit
 1492
 0.3
chr22_37730993_37731243 0.40 CYTH4
 cytohesin 4
 25109
 0.13
chr15_96897228_96897556 0.39 AC087477.1
 Uncharacterized protein
 7095
 0.17
chr11_69191812_69191963 0.36 MYEOV
 myeloma overexpressed
 130262
 0.05
chr13_20735020_20735550 0.35 GJA3
 gap junction protein, alpha 3, 46kDa
 97
 0.97
chr1_236305972_236306453 0.34 GPR137B
 G protein-coupled receptor 137B
 144
 0.97
chr4_99214803_99214954 0.32 RP11-323J4.1
32097
 0.19
chrX_110339181_110339857 0.30 PAK3
 p21 protein (Cdc42/Rac)-activated kinase 3
 69
 0.99
chr21_28339057_28339347 0.30 ADAMTS5
 ADAM metallopeptidase with thrombospondin type 1 motif, 5
 370
 0.89
chr20_39766624_39767421 0.29 RP1-1J6.2
379
 0.79
chr11_61485680_61486023 0.28 MYRF
 myelin regulatory factor
 34270
 0.11
chr1_20812928_20813453 0.28 CAMK2N1
 calcium/calmodulin-dependent protein kinase II inhibitor 1
 477
 0.82
chr10_80166967_80167185 0.28 ENSG00000201393
 .
 39812
 0.22
chr13_43148594_43148878 0.28 TNFSF11
 tumor necrosis factor (ligand) superfamily, member 11
 376
 0.93
chr1_23750455_23751189 0.28 TCEA3
 transcription elongation factor A (SII), 3
 378
 0.83
chr14_23306914_23307085 0.28 MMP14
 matrix metallopeptidase 14 (membrane-inserted)
 478
 0.61
chr14_23821578_23822379 0.28 SLC22A17
 solute carrier family 22, member 17
 91
 0.91
chr7_130572613_130572896 0.27 ENSG00000226380
 .
 10456
 0.27
chr18_7117321_7117760 0.27 LAMA1
 laminin, alpha 1
 273
 0.94
chr10_60235657_60235933 0.27 BICC1
 bicaudal C homolog 1 (Drosophila)
 37105
 0.2
chr12_59313444_59313663 0.27 LRIG3
 leucine-rich repeats and immunoglobulin-like domains 3
 226
 0.87
chr1_33219625_33220407 0.27 KIAA1522
 KIAA1522
 394
 0.82
chr2_177502027_177502943 0.27 ENSG00000252027
 .
 26919
 0.25
chr9_97681675_97681826 0.26 RP11-54O15.3
15478
 0.17
chr2_129166329_129166512 0.26 ENSG00000238379
 .
 36352
 0.19
chr10_17496627_17496975 0.26 ST8SIA6
 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
 472
 0.84
chr7_150822281_150822432 0.26 AGAP3
 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
 7060
 0.11
chr8_77594904_77595092 0.26 ZFHX4
 zinc finger homeobox 4
 236
 0.67
chr19_8428717_8428931 0.26 ANGPTL4
 angiopoietin-like 4
 211
 0.87
chr11_118492062_118492969 0.25 PHLDB1
 pleckstrin homology-like domain, family B, member 1
 14157
 0.11
chr3_127175696_127176137 0.25 TPRA1
 transmembrane protein, adipocyte asscociated 1
 123364
 0.05
chr19_54982330_54982580 0.25 CDC42EP5
 CDC42 effector protein (Rho GTPase binding) 5
 1956
 0.17
chr13_36704716_36705075 0.25 DCLK1
 doublecortin-like kinase 1
 548
 0.84
chr15_29967513_29967692 0.25 RP11-680F8.1
408
 0.87
chr4_176568169_176568320 0.25 GPM6A
 glycoprotein M6A
 140294
 0.05
chr7_193532_193958 0.25 AC093627.12
435
 0.67
chr2_101436870_101437355 0.25 NPAS2
 neuronal PAS domain protein 2
 375
 0.86
chr17_70587270_70588900 0.24 ENSG00000200783
 .
 72206
 0.12
chrX_149530380_149530720 0.24 MAMLD1
 mastermind-like domain containing 1
 1001
 0.68
chr10_123779225_123779376 0.24 TACC2
 transforming, acidic coiled-coil containing protein 2
 2151
 0.37
chr10_29264874_29265025 0.24 ENSG00000199402
 .
 101513
 0.08
chr3_192233089_192233240 0.24 FGF12-AS2
 FGF12 antisense RNA 2
 353
 0.83
chr22_44727371_44727573 0.24 KIAA1644
 KIAA1644
 18741
 0.22
chr21_38119758_38120093 0.23 SIM2
 single-minded family bHLH transcription factor 2
 35059
 0.15
chr10_135148565_135149526 0.23 CALY
 calcyon neuron-specific vesicular protein
 1331
 0.22
chr1_113286335_113286536 0.23 FAM19A3
 family with sequence similarity 19 (chemokine (C-C motif)-like), member A3
 23236
 0.11
chr1_210484700_210484949 0.23 HHAT
 hedgehog acyltransferase
 16772
 0.23
chr3_8671283_8671434 0.23 SSUH2
 ssu-2 homolog (C. elegans)
 15126
 0.15
chr3_36422437_36422689 0.23 STAC
 SH3 and cysteine rich domain
 498
 0.89
chr5_95767258_95767555 0.23 PCSK1
 proprotein convertase subtilisin/kexin type 1
 458
 0.88
chrX_146273220_146273371 0.23 ENSG00000216171
 .
 1990
 0.19
chr12_53612888_53613255 0.23 RARG
 retinoic acid receptor, gamma
 972
 0.4
chr19_38714929_38715117 0.23 DPF1
 D4, zinc and double PHD fingers family 1
 133
 0.92
chr2_2650168_2650319 0.22 MYT1L
 myelin transcription factor 1-like
 315277
 0.01
chr19_17797735_17797934 0.22 UNC13A
 unc-13 homolog A (C. elegans)
 1174
 0.41
chr19_45888782_45889257 0.22 PPP1R13L
 protein phosphatase 1, regulatory subunit 13 like
 143
 0.93
chr9_100849786_100850488 0.22 TRIM14
 tripartite motif containing 14
 4706
 0.2
chr3_159756658_159757107 0.22 LINC01100
 long intergenic non-protein coding RNA 1100
 23071
 0.18
chr4_148693853_148694244 0.22 ENSG00000264274
 .
 9698
 0.18
chr11_101918104_101918467 0.22 C11orf70
 chromosome 11 open reading frame 70
 96
 0.96
chr8_28347493_28348400 0.21 FBXO16
 F-box protein 16
 111
 0.95
chr4_2403656_2404488 0.21 ZFYVE28
 zinc finger, FYVE domain containing 28
 4320
 0.21
chr10_830663_830851 0.21 LARP4B
 La ribonucleoprotein domain family, member 4B
 33029
 0.18
chr22_46933754_46934840 0.21 CELSR1
 cadherin, EGF LAG seven-pass G-type receptor 1
 1230
 0.46
chr16_29231551_29231794 0.21 RP11-231C14.6
91999
 0.06
chr1_99470479_99470698 0.21 LPPR5
 Lipid phosphate phosphatase-related protein type 5
 0
 0.95
chr4_154407741_154408009 0.21 KIAA0922
 KIAA0922
 20374
 0.23
chr17_41984921_41985550 0.21 MPP2
 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
 108
 0.94
chr20_57426029_57426307 0.20 GNAS-AS1
 GNAS antisense RNA 1
 210
 0.89
chrY_16636977_16637245 0.20 NLGN4Y
 neuroligin 4, Y-linked
 657
 0.84
chr7_107612091_107612242 0.20 ENSG00000238297
 .
 28261
 0.14
chr19_40698095_40698531 0.20 MAP3K10
 mitogen-activated protein kinase kinase kinase 10
 662
 0.59
chr19_50356246_50356397 0.20 PTOV1
 prostate tumor overexpressed 1
 1342
 0.13
chr6_104981791_104982069 0.20 ENSG00000252944
 .
 232767
 0.02
chr1_31380173_31380807 0.20 SDC3
 syndecan 3
 1118
 0.44
chr7_562042_562272 0.20 PDGFA
 platelet-derived growth factor alpha polypeptide
 2224
 0.31
chr20_2110844_2110995 0.19 ENSG00000263452
 .
 27008
 0.18
chr5_78985270_78986298 0.19 CMYA5
 cardiomyopathy associated 5
 84
 0.98
chr17_79093601_79093928 0.19 ENSG00000207736
 .
 5409
 0.1
chr4_150999769_151000790 0.19 DCLK2
 doublecortin-like kinase 2
 99
 0.98
chr16_54321004_54321411 0.19 IRX3
 iroquois homeobox 3
 532
 0.83
chr8_1771644_1772131 0.19 ARHGEF10
 Rho guanine nucleotide exchange factor (GEF) 10
 255
 0.93
chr7_560180_560411 0.19 PDGFA
 platelet-derived growth factor alpha polypeptide
 362
 0.88
chr7_73704189_73704652 0.19 CLIP2
 CAP-GLY domain containing linker protein 2
 615
 0.73
chr16_67433264_67433415 0.19 ZDHHC1
 zinc finger, DHHC-type containing 1
 1555
 0.23
chr14_37050333_37050591 0.19 NKX2-8
 NK2 homeobox 8
 1350
 0.4
chr2_130901985_130902795 0.19 CCDC74B
 coiled-coil domain containing 74B
 177
 0.9
chr8_494526_494820 0.19 TDRP
 testis development related protein
 164
 0.97
chr1_10926741_10927032 0.18 CASZ1
 castor zinc finger 1
 70179
 0.09
chr17_19374169_19374649 0.18 ENSG00000265335
 .
 50817
 0.08
chr7_150812372_150812612 0.18 AGAP3
 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
 727
 0.51
chr22_16192781_16192941 0.18 LL22NC03-N64E9.1
11857
 0.18
chr1_210465594_210466382 0.18 HHAT
 hedgehog acyltransferase
 35608
 0.17
chr4_55096373_55096991 0.18 PDGFRA
 platelet-derived growth factor receptor, alpha polypeptide
 193
 0.97
chr2_73496654_73496805 0.18 FBXO41
 F-box protein 41
 1314
 0.36
chr16_85548809_85549111 0.18 ENSG00000264203
 .
 73862
 0.1
chr2_191629077_191629228 0.18 AC006460.2
55710
 0.13
chr6_28522205_28522356 0.18 GPX5
 glutathione peroxidase 5 (epididymal androgen-related protein)
 28491
 0.14
chr11_118791642_118792157 0.18 BCL9L
 B-cell CLL/lymphoma 9-like
 2286
 0.14
chr10_30346435_30346778 0.18 KIAA1462
 KIAA1462
 1847
 0.5
chr17_36621277_36621585 0.18 ARHGAP23
 Rho GTPase activating protein 23
 6749
 0.17
chr14_99655246_99655958 0.18 AL162151.4
30849
 0.2
chr15_33602886_33603116 0.18 RP11-489D6.2
141
 0.53
chr8_102168134_102168418 0.18 ENSG00000202360
 .
 18089
 0.22
chr2_133427812_133428020 0.18 LYPD1
 LY6/PLAUR domain containing 1
 138
 0.97
chr15_57884211_57884584 0.18 GCOM1
 GRINL1A complex locus 1
 166
 0.33
chr16_2128784_2128935 0.18 TSC2
 tuberous sclerosis 2
 4332
 0.07
chr6_3248086_3248639 0.18 PSMG4
 proteasome (prosome, macropain) assembly chaperone 4
 10766
 0.18
chr19_39466589_39467071 0.18 FBXO17
 F-box protein 17
 280
 0.84
chr13_30168298_30169638 0.17 SLC7A1
 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
 857
 0.74
chr2_27717607_27718081 0.17 FNDC4
 fibronectin type III domain containing 4
 268
 0.82
chr12_22093968_22094205 0.17 ABCC9
 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
 81
 0.98
chr6_80656707_80657785 0.17 ELOVL4
 ELOVL fatty acid elongase 4
 51
 0.98
chr19_19006269_19006725 0.17 GDF1
 growth differentiation factor 1
 408
 0.46
chr3_125985987_125986785 0.17 ALDH1L1-AS2
 ALDH1L1 antisense RNA 2
 60288
 0.1
chr7_767439_768007 0.17 PRKAR1B
 protein kinase, cAMP-dependent, regulatory, type I, beta
 436
 0.68
chr4_14864468_14865022 0.17 CPEB2
 cytoplasmic polyadenylation element binding protein 2
 139553
 0.05
chr5_170024412_170024773 0.17 CTC-265N9.1
83849
 0.08
chr8_79428088_79428454 0.17 PKIA
 protein kinase (cAMP-dependent, catalytic) inhibitor alpha
 103
 0.98
chr2_132439969_132440520 0.17 C2orf27A
 chromosome 2 open reading frame 27A
 39704
 0.17
chr11_8041404_8041600 0.17 TUB
 tubby bipartite transcription factor
 711
 0.56
chr16_66914963_66915191 0.17 PDP2
 pyruvate dehyrogenase phosphatase catalytic subunit 2
 567
 0.61
chr19_1748094_1748245 0.17 ONECUT3
 one cut homeobox 3
 4203
 0.16
chr16_88449218_88449497 0.17 ZNF469
 zinc finger protein 469
 44522
 0.14
chr11_69457709_69458273 0.16 CCND1
 cyclin D1
 2017
 0.36
chr11_62691064_62691268 0.16 CHRM1
 cholinergic receptor, muscarinic 1
 1887
 0.2
chr20_42955224_42955721 0.16 R3HDML
 R3H domain containing-like
 10154
 0.11
chrX_117957425_117957978 0.16 ZCCHC12
 zinc finger, CCHC domain containing 12
 52
 0.98
chr20_44034499_44035314 0.16 DBNDD2
 dysbindin (dystrobrevin binding protein 1) domain containing 2
 45
 0.96
chr19_49842468_49842681 0.16 CD37
 CD37 molecule
 2102
 0.15
chr4_52904501_52904984 0.16 SGCB
 sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
 94
 0.97
chr9_34651822_34652525 0.16 IL11RA
 interleukin 11 receptor, alpha
 16
 0.94
chr13_102068214_102068409 0.16 NALCN
 sodium leak channel, non-selective
 395
 0.91
chrX_12156590_12157176 0.16 FRMPD4
 FERM and PDZ domain containing 4
 298
 0.9
chr4_7940010_7940502 0.16 AC097381.1
472
 0.75
chr5_137801989_137802208 0.16 EGR1
 early growth response 1
 919
 0.54
chr1_225117342_225117684 0.16 DNAH14
 dynein, axonemal, heavy chain 14
 129
 0.98
chr9_17579467_17579684 0.16 SH3GL2
 SH3-domain GRB2-like 2
 454
 0.91
chr19_50836422_50837123 0.16 KCNC3
 potassium voltage-gated channel, Shaw-related subfamily, member 3
 0
 0.95
chr1_82268816_82269203 0.16 LPHN2
 latrophilin 2
 2927
 0.41
chr11_35641402_35641625 0.16 FJX1
 four jointed box 1 (Drosophila)
 1778
 0.42
chr4_187476503_187476829 0.16 MTNR1A
 melatonin receptor 1A
 55
 0.7
chr20_10197984_10198249 0.16 SNAP25
 synaptosomal-associated protein, 25kDa
 1362
 0.42
chr1_153581254_153581448 0.16 S100A16
 S100 calcium binding protein A16
 462
 0.62
chr2_56151103_56151254 0.16 EFEMP1
 EGF containing fibulin-like extracellular matrix protein 1
 96
 0.97
chr6_85474025_85474422 0.16 TBX18
 T-box 18
 14
 0.99
chr16_54962446_54962612 0.16 IRX5
 iroquois homeobox 5
 2245
 0.47
chr6_28227027_28227486 0.16 NKAPL
 NFKB activating protein-like
 158
 0.61
chr6_33589286_33590289 0.15 ITPR3
 inositol 1,4,5-trisphosphate receptor, type 3
 626
 0.65
chr19_39360695_39361085 0.15 CTC-360G5.6
91
 0.64
chr11_65158052_65158759 0.15 FRMD8
 FERM domain containing 8
 4006
 0.13
chr13_22257522_22257673 0.15 FGF9
 fibroblast growth factor 9
 12075
 0.25
chr19_8204803_8204954 0.15 FBN3
 fibrillin 3
 7772
 0.19
chr12_13045017_13045168 0.15 GPRC5A
 G protein-coupled receptor, family C, group 5, member A
 184
 0.93
chr7_558289_558902 0.15 PDGFA
 platelet-derived growth factor alpha polypeptide
 436
 0.84
chr19_39904322_39904875 0.15 PLEKHG2
 pleckstrin homology domain containing, family G (with RhoGef domain) member 2
 146
 0.89
chr17_70026380_70026708 0.15 AC007461.1
 Uncharacterized protein
 9620
 0.31
chr6_133562881_133563193 0.15 EYA4
 eyes absent homolog 4 (Drosophila)
 268
 0.95
chr4_5889500_5889651 0.15 CRMP1
 collapsin response mediator protein 1
 633
 0.79
chr18_12287984_12288154 0.15 ENSG00000199702
 .
 16124
 0.16
chrX_52927117_52927336 0.15 FAM156B
 family with sequence similarity 156, member B
 350
 0.88
chr9_98279334_98279613 0.15 PTCH1
 patched 1
 134
 0.95
chr19_40972554_40972858 0.15 SPTBN4
 spectrin, beta, non-erythrocytic 4
 420
 0.65
chr8_22085028_22085274 0.15 PHYHIP
 phytanoyl-CoA 2-hydroxylase interacting protein
 55
 0.96
chr19_42456013_42456185 0.15 RABAC1
 Rab acceptor 1 (prenylated)
 6967
 0.14
chrX_10141481_10141728 0.15 CLCN4
 chloride channel, voltage-sensitive 4
 15032
 0.23
chr11_62312562_62314176 0.15 RP11-864I4.4
102
 0.64
chr3_184056155_184056581 0.15 FAM131A
 family with sequence similarity 131, member A
 249
 0.84
chr7_1600163_1600314 0.15 TMEM184A
 transmembrane protein 184A
 219
 0.92
chr13_23733598_23733940 0.15 ENSG00000207157
 .
 6944
 0.23
chr16_3241653_3241969 0.15 AJ003147.9
3599
 0.12
chr5_131593477_131594185 0.15 PDLIM4
 PDZ and LIM domain 4
 431
 0.81
chr1_38259533_38260044 0.15 MANEAL
 mannosidase, endo-alpha-like
 233
 0.86
chr22_30641646_30641949 0.15 RP1-102K2.8
187
 0.85
chr6_36567708_36568239 0.15 SRSF3
 serine/arginine-rich splicing factor 3
 5828
 0.16
chr19_56576699_56576850 0.15 ZNF787
 zinc finger protein 787
 38079
 0.1
chr5_137609759_137610630 0.15 GFRA3
 GDNF family receptor alpha 3
 60
 0.96
chr9_117880223_117880437 0.15 TNC
 tenascin C
 148
 0.97
chr17_4902045_4902282 0.15 KIF1C
 kinesin family member 1C
 914
 0.26
chr5_124827830_124828314 0.15 ENSG00000222107
 .
 141248
 0.05
chr17_62971851_62972399 0.15 AMZ2P1
 archaelysin family metallopeptidase 2 pseudogene 1
 2490
 0.23
chr5_139283809_139284341 0.15 NRG2
 neuregulin 2
 93
 0.98
chr7_138720144_138720977 0.15 ZC3HAV1L
 zinc finger CCCH-type, antiviral 1-like
 215
 0.95
chr5_134824456_134824665 0.15 TIFAB
 TRAF-interacting protein with forkhead-associated domain, family member B
 36471
 0.11
chr1_20811158_20811808 0.14 CAMK2N1
 calcium/calmodulin-dependent protein kinase II inhibitor 1
 1230
 0.48
chr16_65157518_65157704 0.14 CDH11
 cadherin 11, type 2, OB-cadherin (osteoblast)
 1343
 0.63
chr11_70244216_70245100 0.14 CTTN
 cortactin
 11
 0.53
chr17_9142709_9143234 0.14 RP11-85B7.4
43520
 0.15
chr22_18958500_18958651 0.14 DGCR5
 DiGeorge syndrome critical region gene 5 (non-protein coding)
 479
 0.78
chr5_95767628_95767788 0.14 PCSK1
 proprotein convertase subtilisin/kexin type 1
 156
 0.97
chr18_74271196_74271347 0.14 LINC00908
 long intergenic non-protein coding RNA 908
 30397
 0.18
chr1_19282077_19282398 0.14 IFFO2
 intermediate filament family orphan 2
 45
 0.98
chr10_74544262_74544615 0.14 RP11-354E23.5
18120
 0.19
chr1_40098862_40099023 0.14 RP1-144F13.3
146
 0.66
chr7_158823123_158823874 0.14 ENSG00000231419
 .
 22386
 0.25
chr8_17354234_17354457 0.14 SLC7A2
 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
 252
 0.95

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of EGR1_EGR4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
0.2 0.5 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.1 0.4 GO:0008049 male courtship behavior(GO:0008049)
0.1 0.3 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1 0.2 GO:0009405 pathogenesis(GO:0009405)
0.1 0.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 0.1 GO:0060748 tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.1 0.2 GO:0032808 lacrimal gland development(GO:0032808)
0.1 0.2 GO:0060685 regulation of prostatic bud formation(GO:0060685)
0.1 0.2 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.1 0.2 GO:0010107 potassium ion import(GO:0010107)
0.1 0.2 GO:0043589 skin morphogenesis(GO:0043589)
0.1 0.2 GO:0002689 negative regulation of leukocyte chemotaxis(GO:0002689)
0.1 0.2 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 0.1 GO:0060596 mammary placode formation(GO:0060596)
0.1 0.3 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.1 0.1 GO:0072110 glomerular mesangial cell proliferation(GO:0072110) regulation of glomerular mesangial cell proliferation(GO:0072124)
0.0 0.1 GO:0016081 synaptic vesicle docking(GO:0016081)
0.0 0.2 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367)
0.0 0.0 GO:0060492 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) iris morphogenesis(GO:0061072)
0.0 0.0 GO:0072033 renal vesicle formation(GO:0072033)
0.0 0.1 GO:0061364 apoptotic process involved in luteolysis(GO:0061364)
0.0 0.1 GO:0048867 stem cell fate commitment(GO:0048865) stem cell fate determination(GO:0048867)
0.0 0.1 GO:0033087 negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0 0.3 GO:0016540 protein autoprocessing(GO:0016540)
0.0 0.2 GO:0008218 bioluminescence(GO:0008218)
0.0 0.2 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.3 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.4 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.1 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.0 GO:0072239 metanephric glomerulus development(GO:0072224) metanephric glomerulus vasculature development(GO:0072239)
0.0 0.3 GO:0060438 trachea development(GO:0060438)
0.0 0.1 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.2 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.2 GO:0045992 negative regulation of embryonic development(GO:0045992)
0.0 0.2 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.2 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.1 GO:0032353 negative regulation of hormone metabolic process(GO:0032351) negative regulation of hormone biosynthetic process(GO:0032353)
0.0 0.3 GO:0021955 central nervous system neuron axonogenesis(GO:0021955)
0.0 0.1 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.1 GO:0072047 proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.0 0.1 GO:1900121 regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.0 0.1 GO:0051451 myoblast migration(GO:0051451)
0.0 0.1 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0 0.0 GO:0090185 negative regulation of kidney development(GO:0090185)
0.0 0.1 GO:0007144 female meiosis I(GO:0007144)
0.0 0.1 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 0.3 GO:0042249 establishment of planar polarity of embryonic epithelium(GO:0042249)
0.0 0.1 GO:0034201 response to oleic acid(GO:0034201)
0.0 0.1 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
0.0 0.2 GO:0033240 positive regulation of cellular amine metabolic process(GO:0033240)
0.0 0.1 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.0 0.1 GO:0060291 long-term synaptic potentiation(GO:0060291)
0.0 0.2 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.2 GO:0060638 mesenchymal-epithelial cell signaling(GO:0060638)
0.0 0.2 GO:0015802 basic amino acid transport(GO:0015802)
0.0 0.0 GO:0060435 bronchiole development(GO:0060435)
0.0 0.1 GO:0060992 response to fungicide(GO:0060992)
0.0 0.1 GO:0002085 inhibition of neuroepithelial cell differentiation(GO:0002085)
0.0 0.1 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.0 0.1 GO:0010996 response to auditory stimulus(GO:0010996)
0.0 0.1 GO:0010658 striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0 0.1 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0 0.3 GO:1901678 iron coordination entity transport(GO:1901678)
0.0 0.3 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.1 GO:0034653 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0 0.2 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.1 GO:0090218 positive regulation of lipid kinase activity(GO:0090218)
0.0 0.0 GO:0002068 glandular epithelial cell development(GO:0002068)
0.0 0.0 GO:1901722 cell proliferation involved in metanephros development(GO:0072203) regulation of cell proliferation involved in kidney development(GO:1901722)
0.0 0.0 GO:0003179 heart valve development(GO:0003170) heart valve morphogenesis(GO:0003179)
0.0 0.1 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.1 GO:1901890 positive regulation of focal adhesion assembly(GO:0051894) positive regulation of cell junction assembly(GO:1901890) positive regulation of adherens junction organization(GO:1903393)
0.0 0.1 GO:0001993 regulation of systemic arterial blood pressure by norepinephrine-epinephrine(GO:0001993) positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321)
0.0 0.1 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.1 GO:0043374 CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.0 GO:0060737 prostate gland morphogenetic growth(GO:0060737)
0.0 0.3 GO:0035329 hippo signaling(GO:0035329)
0.0 0.1 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.2 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.1 GO:0071731 response to nitric oxide(GO:0071731)
0.0 0.3 GO:0042745 circadian sleep/wake cycle(GO:0042745)
0.0 0.1 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.1 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.0 0.1 GO:0055075 potassium ion homeostasis(GO:0055075)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.0 0.0 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.0 0.1 GO:0009296 obsolete flagellum assembly(GO:0009296)
0.0 0.0 GO:0048505 regulation of development, heterochronic(GO:0040034) regulation of timing of cell differentiation(GO:0048505)
0.0 0.1 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.1 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 0.3 GO:1902749 regulation of G2/M transition of mitotic cell cycle(GO:0010389) regulation of cell cycle G2/M phase transition(GO:1902749)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.1 GO:0043457 regulation of cellular respiration(GO:0043457)
0.0 0.3 GO:0006541 glutamine metabolic process(GO:0006541)
0.0 0.1 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.1 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.0 0.0 GO:0060033 Mullerian duct regression(GO:0001880) anatomical structure regression(GO:0060033)
0.0 0.1 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.0 0.1 GO:0021978 telencephalon regionalization(GO:0021978)
0.0 0.1 GO:0003091 renal water homeostasis(GO:0003091)
0.0 0.0 GO:0050942 positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.0 0.2 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.1 GO:0050955 thermoception(GO:0050955)
0.0 0.0 GO:0051891 positive regulation of cardioblast differentiation(GO:0051891) positive regulation of cardiocyte differentiation(GO:1905209)
0.0 0.1 GO:0015742 alpha-ketoglutarate transport(GO:0015742)
0.0 0.0 GO:0090036 regulation of protein kinase C signaling(GO:0090036) positive regulation of protein kinase C signaling(GO:0090037)
0.0 0.1 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.1 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.0 0.1 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.0 0.1 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.1 GO:0033688 regulation of osteoblast proliferation(GO:0033688)
0.0 0.0 GO:0019614 phenol-containing compound catabolic process(GO:0019336) catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0 0.1 GO:0070141 response to UV-A(GO:0070141)
0.0 0.1 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0 0.2 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.0 0.4 GO:0007566 embryo implantation(GO:0007566)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.0 GO:0006154 adenosine catabolic process(GO:0006154)
0.0 0.1 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.0 GO:0060913 cardiac cell fate determination(GO:0060913)
0.0 0.1 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.0 0.1 GO:0021984 adenohypophysis development(GO:0021984)
0.0 0.0 GO:0009996 negative regulation of cell fate specification(GO:0009996)
0.0 0.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.1 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.1 GO:0060317 cardiac epithelial to mesenchymal transition(GO:0060317)
0.0 0.0 GO:0010661 positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0 0.2 GO:0031069 hair follicle morphogenesis(GO:0031069)
0.0 0.0 GO:0060976 coronary vasculature development(GO:0060976)
0.0 0.0 GO:0014850 response to muscle activity(GO:0014850)
0.0 0.0 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 0.0 GO:0097501 detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0 0.1 GO:0071599 otic vesicle formation(GO:0030916) otic vesicle development(GO:0071599) otic vesicle morphogenesis(GO:0071600)
0.0 0.1 GO:0034629 cellular protein complex localization(GO:0034629)
0.0 0.0 GO:0071503 response to heparin(GO:0071503)
0.0 0.0 GO:0048266 behavioral response to pain(GO:0048266)
0.0 0.0 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.0 GO:0048799 organ maturation(GO:0048799) bone maturation(GO:0070977)
0.0 0.1 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0 0.0 GO:0060684 epithelial-mesenchymal cell signaling(GO:0060684)
0.0 0.0 GO:0022605 oogenesis stage(GO:0022605)
0.0 0.0 GO:1904251 regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.0 0.1 GO:0002090 regulation of receptor internalization(GO:0002090)
0.0 0.1 GO:0030828 positive regulation of cGMP biosynthetic process(GO:0030828)
0.0 0.0 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.2 GO:0050766 positive regulation of phagocytosis(GO:0050766)
0.0 0.0 GO:0045112 integrin biosynthetic process(GO:0045112)
0.0 0.2 GO:0009268 response to pH(GO:0009268)
0.0 0.1 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.0 0.0 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.1 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.0 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.0 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.0 GO:0046877 regulation of saliva secretion(GO:0046877)
0.0 0.1 GO:0002634 regulation of germinal center formation(GO:0002634)
0.0 0.0 GO:0061299 retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.0 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0 0.0 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.0 GO:0006551 leucine metabolic process(GO:0006551)
0.0 0.0 GO:0090598 male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0 0.1 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.0 0.2 GO:0034394 protein localization to cell surface(GO:0034394)
0.0 0.0 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.1 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.0 0.0 GO:0010159 specification of organ position(GO:0010159)
0.0 0.0 GO:0043092 L-amino acid import(GO:0043092)
0.0 0.0 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.0 GO:0032714 negative regulation of interleukin-5 production(GO:0032714)
0.0 0.0 GO:0021932 hindbrain radial glia guided cell migration(GO:0021932)
0.0 0.1 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)
0.0 0.0 GO:0014808 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880) release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0014808) calcium ion transport from endoplasmic reticulum to cytosol(GO:1903514)
0.0 0.0 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.1 GO:0048841 regulation of axon extension involved in axon guidance(GO:0048841)
0.0 0.0 GO:0090205 positive regulation of cholesterol metabolic process(GO:0090205)
0.0 0.0 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.0 GO:0021570 rhombomere 4 development(GO:0021570)
0.0 0.0 GO:0072048 pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048) pattern specification involved in metanephros development(GO:0072268)
0.0 0.0 GO:0034723 DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.1 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.0 0.0 GO:0001757 somite specification(GO:0001757)
0.0 0.0 GO:0045002 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0 0.0 GO:0002326 B cell lineage commitment(GO:0002326)
0.0 0.0 GO:0035625 receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625)
0.0 0.0 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0 0.0 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.0 0.1 GO:0042596 behavioral fear response(GO:0001662) fear response(GO:0042596)
0.0 0.1 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.0 0.0 GO:0042637 catagen(GO:0042637)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.2 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.0 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.0 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.0 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.0 GO:0021819 layer formation in cerebral cortex(GO:0021819)
0.0 0.0 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.0 GO:0060068 vagina development(GO:0060068)
0.0 0.0 GO:0035058 nonmotile primary cilium assembly(GO:0035058)
0.0 0.0 GO:0048935 peripheral nervous system neuron development(GO:0048935)
0.0 0.3 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.2 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.0 0.0 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.0 0.0 GO:0030210 heparin biosynthetic process(GO:0030210)
0.0 0.0 GO:0061043 vascular wound healing(GO:0061042) regulation of vascular wound healing(GO:0061043)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 0.4 GO:0005606 laminin-1 complex(GO:0005606)
0.1 0.2 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.2 GO:0042584 chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.0 0.1 GO:0032449 CBM complex(GO:0032449)
0.0 0.2 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.1 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.1 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.1 GO:0016600 flotillin complex(GO:0016600)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.1 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.3 GO:0071565 nBAF complex(GO:0071565)
0.0 0.4 GO:0005922 connexon complex(GO:0005922)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0005678 obsolete chromatin assembly complex(GO:0005678)
0.0 0.1 GO:0032279 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0 0.0 GO:0032059 bleb(GO:0032059)
0.0 0.1 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.1 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.2 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.3 GO:0005581 collagen trimer(GO:0005581)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0031941 filamentous actin(GO:0031941)
0.0 0.1 GO:0010369 chromocenter(GO:0010369)
0.0 0.2 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.1 GO:0031430 M band(GO:0031430)
0.0 0.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.1 GO:0032156 septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.1 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 0.1 GO:0031512 motile primary cilium(GO:0031512)
0.0 0.4 GO:0043679 axon terminus(GO:0043679)
0.0 0.0 GO:0070852 cell body fiber(GO:0070852)
0.0 0.1 GO:0043205 fibril(GO:0043205)
0.0 0.1 GO:0032589 neuron projection membrane(GO:0032589)
0.0 0.2 GO:0043204 perikaryon(GO:0043204)
0.0 0.2 GO:0016460 myosin II complex(GO:0016460)
0.0 0.0 GO:0043260 laminin-11 complex(GO:0043260)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005113 patched binding(GO:0005113)
0.1 1.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.5 GO:0005110 frizzled-2 binding(GO:0005110)
0.1 0.2 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.2 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.1 0.2 GO:0043559 insulin binding(GO:0043559)
0.1 0.2 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 0.2 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.1 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 0.1 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)
0.0 0.3 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.5 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.1 GO:0070215 obsolete MDM2 binding(GO:0070215)
0.0 0.4 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.1 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.2 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.1 GO:0035198 miRNA binding(GO:0035198)
0.0 0.1 GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0 0.3 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.3 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.1 GO:0070548 L-glutamine aminotransferase activity(GO:0070548)
0.0 0.2 GO:0034416 bisphosphoglycerate phosphatase activity(GO:0034416)
0.0 0.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.2 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 0.1 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.0 0.1 GO:0099604 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0 0.1 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0 0.1 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.0 0.1 GO:0044390 ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.3 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.0 0.1 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.1 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.1 GO:0005148 prolactin receptor binding(GO:0005148)
0.0 0.0 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0030151 molybdenum ion binding(GO:0030151)
0.0 0.1 GO:0031404 chloride ion binding(GO:0031404)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.2 GO:0046625 sphingolipid binding(GO:0046625)
0.0 0.1 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0 0.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.2 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.1 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.1 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.1 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0005112 Notch binding(GO:0005112)
0.0 0.4 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.0 GO:0034711 inhibin binding(GO:0034711)
0.0 0.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0004457 lactate dehydrogenase activity(GO:0004457)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.0 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.0 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.0 GO:0034187 obsolete apolipoprotein E binding(GO:0034187)
0.0 0.1 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 0.0 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.1 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.0 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.1 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.1 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.1 GO:0048185 activin binding(GO:0048185)
0.0 0.0 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.0 GO:0008061 chitin binding(GO:0008061)
0.0 0.1 GO:0015288 porin activity(GO:0015288)
0.0 0.0 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.0 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.0 GO:0032554 purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0 0.1 GO:0030553 cGMP binding(GO:0030553)
0.0 0.2 GO:0005109 frizzled binding(GO:0005109)
0.0 0.0 GO:0004370 glycerol kinase activity(GO:0004370)
0.0 0.1 GO:0004675 transmembrane receptor protein serine/threonine kinase activity(GO:0004675)
0.0 0.0 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.1 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.0 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0 0.0 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0 0.0 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.0 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.0 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.0 0.0 GO:0099528 dopamine neurotransmitter receptor activity(GO:0004952) G-protein coupled neurotransmitter receptor activity(GO:0099528)
0.0 0.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.0 GO:0005346 purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.0 0.0 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.1 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.0 0.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.0 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.0 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.0 GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity(GO:0016847)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.6 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.7 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.1 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.0 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 0.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.5 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.7 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.2 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.2 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.0 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.2 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 0.1 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.4 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.0 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.0 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.0 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0 0.1 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.4 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.3 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.4 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.0 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.3 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.4 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.2 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.6 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.2 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.0 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.0 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.2 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.0 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.2 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.3 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.2 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.1 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.1 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.0 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.0 0.2 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.2 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.2 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.0 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 0.1 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.3 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.2 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.9 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.1 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF