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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for EGR1_EGR4

Z-value: 0.95

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Transcription factors associated with EGR1_EGR4

Gene Symbol	Gene ID	Gene Info
EGR1 Ensembl NCBI GeneCards UniProt	ENSG00000120738.7	EGR1
EGR4 Ensembl NCBI GeneCards UniProt	ENSG00000135625.6	EGR4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
EGR1	chr5_137802391_137802557	1295	0.412483	0.75	1.9e-02	Click!
EGR1	chr5_137802209_137802360	1105	0.470478	0.73	2.6e-02	Click!
EGR1	chr5_137805025_137805176	3921	0.199444	0.67	4.8e-02	Click!
EGR1	chr5_137803301_137803461	2202	0.270567	0.62	7.5e-02	Click!
EGR1	chr5_137801989_137802208	919	0.543403	0.59	9.6e-02	Click!
EGR4	chr2_73518392_73518872	2197	0.234160	0.54	1.4e-01	Click!
EGR4	chr2_73520179_73521065	207	0.917132	0.47	2.1e-01	Click!
EGR4	chr2_73521076_73521227	318	0.855192	0.31	4.1e-01	Click!
EGR4	chr2_73519153_73519304	1601	0.303270	-0.18	6.5e-01	Click!

Activity of the EGR1_EGR4 motif across conditions

Conditions sorted by the z-value of the EGR1_EGR4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr9_133308330_133308718	0.57	HMCN2	hemicentin 2	2855	0.21
chr14_75077508_75077674	0.54	LTBP2	latent transforming growth factor beta binding protein 2	1184	0.5
chr3_55514769_55515136	0.45	WNT5A	wingless-type MMTV integration site family, member 5A	272	0.94
chr9_124480535_124480686	0.45	DAB2IP	DAB2 interacting protein	18961	0.24
chr17_62051691_62051850	0.41	SCN4A	sodium channel, voltage-gated, type IV, alpha subunit	1492	0.3
chr22_37730993_37731243	0.40	CYTH4	cytohesin 4	25109	0.13
chr15_96897228_96897556	0.39	AC087477.1	Uncharacterized protein	7095	0.17
chr11_69191812_69191963	0.36	MYEOV	myeloma overexpressed	130262	0.05
chr13_20735020_20735550	0.35	GJA3	gap junction protein, alpha 3, 46kDa	97	0.97
chr1_236305972_236306453	0.34	GPR137B	G protein-coupled receptor 137B	144	0.97
chr4_99214803_99214954	0.32	RP11-323J4.1		32097	0.19
chrX_110339181_110339857	0.30	PAK3	p21 protein (Cdc42/Rac)-activated kinase 3	69	0.99
chr21_28339057_28339347	0.30	ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif, 5	370	0.89
chr20_39766624_39767421	0.29	RP1-1J6.2		379	0.79
chr11_61485680_61486023	0.28	MYRF	myelin regulatory factor	34270	0.11
chr1_20812928_20813453	0.28	CAMK2N1	calcium/calmodulin-dependent protein kinase II inhibitor 1	477	0.82
chr10_80166967_80167185	0.28	ENSG00000201393	.	39812	0.22
chr13_43148594_43148878	0.28	TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	376	0.93
chr1_23750455_23751189	0.28	TCEA3	transcription elongation factor A (SII), 3	378	0.83
chr14_23306914_23307085	0.28	MMP14	matrix metallopeptidase 14 (membrane-inserted)	478	0.61
chr14_23821578_23822379	0.28	SLC22A17	solute carrier family 22, member 17	91	0.91
chr7_130572613_130572896	0.27	ENSG00000226380	.	10456	0.27
chr18_7117321_7117760	0.27	LAMA1	laminin, alpha 1	273	0.94
chr10_60235657_60235933	0.27	BICC1	bicaudal C homolog 1 (Drosophila)	37105	0.2
chr12_59313444_59313663	0.27	LRIG3	leucine-rich repeats and immunoglobulin-like domains 3	226	0.87
chr1_33219625_33220407	0.27	KIAA1522	KIAA1522	394	0.82
chr2_177502027_177502943	0.27	ENSG00000252027	.	26919	0.25
chr9_97681675_97681826	0.26	RP11-54O15.3		15478	0.17
chr2_129166329_129166512	0.26	ENSG00000238379	.	36352	0.19
chr10_17496627_17496975	0.26	ST8SIA6	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	472	0.84
chr7_150822281_150822432	0.26	AGAP3	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	7060	0.11
chr8_77594904_77595092	0.26	ZFHX4	zinc finger homeobox 4	236	0.67
chr19_8428717_8428931	0.26	ANGPTL4	angiopoietin-like 4	211	0.87
chr11_118492062_118492969	0.25	PHLDB1	pleckstrin homology-like domain, family B, member 1	14157	0.11
chr3_127175696_127176137	0.25	TPRA1	transmembrane protein, adipocyte asscociated 1	123364	0.05
chr19_54982330_54982580	0.25	CDC42EP5	CDC42 effector protein (Rho GTPase binding) 5	1956	0.17
chr13_36704716_36705075	0.25	DCLK1	doublecortin-like kinase 1	548	0.84
chr15_29967513_29967692	0.25	RP11-680F8.1		408	0.87
chr4_176568169_176568320	0.25	GPM6A	glycoprotein M6A	140294	0.05
chr7_193532_193958	0.25	AC093627.12		435	0.67
chr2_101436870_101437355	0.25	NPAS2	neuronal PAS domain protein 2	375	0.86
chr17_70587270_70588900	0.24	ENSG00000200783	.	72206	0.12
chrX_149530380_149530720	0.24	MAMLD1	mastermind-like domain containing 1	1001	0.68
chr10_123779225_123779376	0.24	TACC2	transforming, acidic coiled-coil containing protein 2	2151	0.37
chr10_29264874_29265025	0.24	ENSG00000199402	.	101513	0.08
chr3_192233089_192233240	0.24	FGF12-AS2	FGF12 antisense RNA 2	353	0.83
chr22_44727371_44727573	0.24	KIAA1644	KIAA1644	18741	0.22
chr21_38119758_38120093	0.23	SIM2	single-minded family bHLH transcription factor 2	35059	0.15
chr10_135148565_135149526	0.23	CALY	calcyon neuron-specific vesicular protein	1331	0.22
chr1_113286335_113286536	0.23	FAM19A3	family with sequence similarity 19 (chemokine (C-C motif)-like), member A3	23236	0.11
chr1_210484700_210484949	0.23	HHAT	hedgehog acyltransferase	16772	0.23
chr3_8671283_8671434	0.23	SSUH2	ssu-2 homolog (C. elegans)	15126	0.15
chr3_36422437_36422689	0.23	STAC	SH3 and cysteine rich domain	498	0.89
chr5_95767258_95767555	0.23	PCSK1	proprotein convertase subtilisin/kexin type 1	458	0.88
chrX_146273220_146273371	0.23	ENSG00000216171	.	1990	0.19
chr12_53612888_53613255	0.23	RARG	retinoic acid receptor, gamma	972	0.4
chr19_38714929_38715117	0.23	DPF1	D4, zinc and double PHD fingers family 1	133	0.92
chr2_2650168_2650319	0.22	MYT1L	myelin transcription factor 1-like	315277	0.01
chr19_17797735_17797934	0.22	UNC13A	unc-13 homolog A (C. elegans)	1174	0.41
chr19_45888782_45889257	0.22	PPP1R13L	protein phosphatase 1, regulatory subunit 13 like	143	0.93
chr9_100849786_100850488	0.22	TRIM14	tripartite motif containing 14	4706	0.2
chr3_159756658_159757107	0.22	LINC01100	long intergenic non-protein coding RNA 1100	23071	0.18
chr4_148693853_148694244	0.22	ENSG00000264274	.	9698	0.18
chr11_101918104_101918467	0.22	C11orf70	chromosome 11 open reading frame 70	96	0.96
chr8_28347493_28348400	0.21	FBXO16	F-box protein 16	111	0.95
chr4_2403656_2404488	0.21	ZFYVE28	zinc finger, FYVE domain containing 28	4320	0.21
chr10_830663_830851	0.21	LARP4B	La ribonucleoprotein domain family, member 4B	33029	0.18
chr22_46933754_46934840	0.21	CELSR1	cadherin, EGF LAG seven-pass G-type receptor 1	1230	0.46
chr16_29231551_29231794	0.21	RP11-231C14.6		91999	0.06
chr1_99470479_99470698	0.21	LPPR5	Lipid phosphate phosphatase-related protein type 5	0	0.95
chr4_154407741_154408009	0.21	KIAA0922	KIAA0922	20374	0.23
chr17_41984921_41985550	0.21	MPP2	membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)	108	0.94
chr20_57426029_57426307	0.20	GNAS-AS1	GNAS antisense RNA 1	210	0.89
chrY_16636977_16637245	0.20	NLGN4Y	neuroligin 4, Y-linked	657	0.84
chr7_107612091_107612242	0.20	ENSG00000238297	.	28261	0.14
chr19_40698095_40698531	0.20	MAP3K10	mitogen-activated protein kinase kinase kinase 10	662	0.59
chr19_50356246_50356397	0.20	PTOV1	prostate tumor overexpressed 1	1342	0.13
chr6_104981791_104982069	0.20	ENSG00000252944	.	232767	0.02
chr1_31380173_31380807	0.20	SDC3	syndecan 3	1118	0.44
chr7_562042_562272	0.20	PDGFA	platelet-derived growth factor alpha polypeptide	2224	0.31
chr20_2110844_2110995	0.19	ENSG00000263452	.	27008	0.18
chr5_78985270_78986298	0.19	CMYA5	cardiomyopathy associated 5	84	0.98
chr17_79093601_79093928	0.19	ENSG00000207736	.	5409	0.1
chr4_150999769_151000790	0.19	DCLK2	doublecortin-like kinase 2	99	0.98
chr16_54321004_54321411	0.19	IRX3	iroquois homeobox 3	532	0.83
chr8_1771644_1772131	0.19	ARHGEF10	Rho guanine nucleotide exchange factor (GEF) 10	255	0.93
chr7_560180_560411	0.19	PDGFA	platelet-derived growth factor alpha polypeptide	362	0.88
chr7_73704189_73704652	0.19	CLIP2	CAP-GLY domain containing linker protein 2	615	0.73
chr16_67433264_67433415	0.19	ZDHHC1	zinc finger, DHHC-type containing 1	1555	0.23
chr14_37050333_37050591	0.19	NKX2-8	NK2 homeobox 8	1350	0.4
chr2_130901985_130902795	0.19	CCDC74B	coiled-coil domain containing 74B	177	0.9
chr8_494526_494820	0.19	TDRP	testis development related protein	164	0.97
chr1_10926741_10927032	0.18	CASZ1	castor zinc finger 1	70179	0.09
chr17_19374169_19374649	0.18	ENSG00000265335	.	50817	0.08
chr7_150812372_150812612	0.18	AGAP3	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	727	0.51
chr22_16192781_16192941	0.18	LL22NC03-N64E9.1		11857	0.18
chr1_210465594_210466382	0.18	HHAT	hedgehog acyltransferase	35608	0.17
chr4_55096373_55096991	0.18	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	193	0.97
chr2_73496654_73496805	0.18	FBXO41	F-box protein 41	1314	0.36
chr16_85548809_85549111	0.18	ENSG00000264203	.	73862	0.1
chr2_191629077_191629228	0.18	AC006460.2		55710	0.13
chr6_28522205_28522356	0.18	GPX5	glutathione peroxidase 5 (epididymal androgen-related protein)	28491	0.14
chr11_118791642_118792157	0.18	BCL9L	B-cell CLL/lymphoma 9-like	2286	0.14
chr10_30346435_30346778	0.18	KIAA1462	KIAA1462	1847	0.5
chr17_36621277_36621585	0.18	ARHGAP23	Rho GTPase activating protein 23	6749	0.17
chr14_99655246_99655958	0.18	AL162151.4		30849	0.2
chr15_33602886_33603116	0.18	RP11-489D6.2		141	0.53
chr8_102168134_102168418	0.18	ENSG00000202360	.	18089	0.22
chr2_133427812_133428020	0.18	LYPD1	LY6/PLAUR domain containing 1	138	0.97
chr15_57884211_57884584	0.18	GCOM1	GRINL1A complex locus 1	166	0.33
chr16_2128784_2128935	0.18	TSC2	tuberous sclerosis 2	4332	0.07
chr6_3248086_3248639	0.18	PSMG4	proteasome (prosome, macropain) assembly chaperone 4	10766	0.18
chr19_39466589_39467071	0.18	FBXO17	F-box protein 17	280	0.84
chr13_30168298_30169638	0.17	SLC7A1	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	857	0.74
chr2_27717607_27718081	0.17	FNDC4	fibronectin type III domain containing 4	268	0.82
chr12_22093968_22094205	0.17	ABCC9	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	81	0.98
chr6_80656707_80657785	0.17	ELOVL4	ELOVL fatty acid elongase 4	51	0.98
chr19_19006269_19006725	0.17	GDF1	growth differentiation factor 1	408	0.46
chr3_125985987_125986785	0.17	ALDH1L1-AS2	ALDH1L1 antisense RNA 2	60288	0.1
chr7_767439_768007	0.17	PRKAR1B	protein kinase, cAMP-dependent, regulatory, type I, beta	436	0.68
chr4_14864468_14865022	0.17	CPEB2	cytoplasmic polyadenylation element binding protein 2	139553	0.05
chr5_170024412_170024773	0.17	CTC-265N9.1		83849	0.08
chr8_79428088_79428454	0.17	PKIA	protein kinase (cAMP-dependent, catalytic) inhibitor alpha	103	0.98
chr2_132439969_132440520	0.17	C2orf27A	chromosome 2 open reading frame 27A	39704	0.17
chr11_8041404_8041600	0.17	TUB	tubby bipartite transcription factor	711	0.56
chr16_66914963_66915191	0.17	PDP2	pyruvate dehyrogenase phosphatase catalytic subunit 2	567	0.61
chr19_1748094_1748245	0.17	ONECUT3	one cut homeobox 3	4203	0.16
chr16_88449218_88449497	0.17	ZNF469	zinc finger protein 469	44522	0.14
chr11_69457709_69458273	0.16	CCND1	cyclin D1	2017	0.36
chr11_62691064_62691268	0.16	CHRM1	cholinergic receptor, muscarinic 1	1887	0.2
chr20_42955224_42955721	0.16	R3HDML	R3H domain containing-like	10154	0.11
chrX_117957425_117957978	0.16	ZCCHC12	zinc finger, CCHC domain containing 12	52	0.98
chr20_44034499_44035314	0.16	DBNDD2	dysbindin (dystrobrevin binding protein 1) domain containing 2	45	0.96
chr19_49842468_49842681	0.16	CD37	CD37 molecule	2102	0.15
chr4_52904501_52904984	0.16	SGCB	sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)	94	0.97
chr9_34651822_34652525	0.16	IL11RA	interleukin 11 receptor, alpha	16	0.94
chr13_102068214_102068409	0.16	NALCN	sodium leak channel, non-selective	395	0.91
chrX_12156590_12157176	0.16	FRMPD4	FERM and PDZ domain containing 4	298	0.9
chr4_7940010_7940502	0.16	AC097381.1		472	0.75
chr5_137801989_137802208	0.16	EGR1	early growth response 1	919	0.54
chr1_225117342_225117684	0.16	DNAH14	dynein, axonemal, heavy chain 14	129	0.98
chr9_17579467_17579684	0.16	SH3GL2	SH3-domain GRB2-like 2	454	0.91
chr19_50836422_50837123	0.16	KCNC3	potassium voltage-gated channel, Shaw-related subfamily, member 3	0	0.95
chr1_82268816_82269203	0.16	LPHN2	latrophilin 2	2927	0.41
chr11_35641402_35641625	0.16	FJX1	four jointed box 1 (Drosophila)	1778	0.42
chr4_187476503_187476829	0.16	MTNR1A	melatonin receptor 1A	55	0.7
chr20_10197984_10198249	0.16	SNAP25	synaptosomal-associated protein, 25kDa	1362	0.42
chr1_153581254_153581448	0.16	S100A16	S100 calcium binding protein A16	462	0.62
chr2_56151103_56151254	0.16	EFEMP1	EGF containing fibulin-like extracellular matrix protein 1	96	0.97
chr6_85474025_85474422	0.16	TBX18	T-box 18	14	0.99
chr16_54962446_54962612	0.16	IRX5	iroquois homeobox 5	2245	0.47
chr6_28227027_28227486	0.16	NKAPL	NFKB activating protein-like	158	0.61
chr6_33589286_33590289	0.15	ITPR3	inositol 1,4,5-trisphosphate receptor, type 3	626	0.65
chr19_39360695_39361085	0.15	CTC-360G5.6		91	0.64
chr11_65158052_65158759	0.15	FRMD8	FERM domain containing 8	4006	0.13
chr13_22257522_22257673	0.15	FGF9	fibroblast growth factor 9	12075	0.25
chr19_8204803_8204954	0.15	FBN3	fibrillin 3	7772	0.19
chr12_13045017_13045168	0.15	GPRC5A	G protein-coupled receptor, family C, group 5, member A	184	0.93
chr7_558289_558902	0.15	PDGFA	platelet-derived growth factor alpha polypeptide	436	0.84
chr19_39904322_39904875	0.15	PLEKHG2	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	146	0.89
chr17_70026380_70026708	0.15	AC007461.1	Uncharacterized protein	9620	0.31
chr6_133562881_133563193	0.15	EYA4	eyes absent homolog 4 (Drosophila)	268	0.95
chr4_5889500_5889651	0.15	CRMP1	collapsin response mediator protein 1	633	0.79
chr18_12287984_12288154	0.15	ENSG00000199702	.	16124	0.16
chrX_52927117_52927336	0.15	FAM156B	family with sequence similarity 156, member B	350	0.88
chr9_98279334_98279613	0.15	PTCH1	patched 1	134	0.95
chr19_40972554_40972858	0.15	SPTBN4	spectrin, beta, non-erythrocytic 4	420	0.65
chr8_22085028_22085274	0.15	PHYHIP	phytanoyl-CoA 2-hydroxylase interacting protein	55	0.96
chr19_42456013_42456185	0.15	RABAC1	Rab acceptor 1 (prenylated)	6967	0.14
chrX_10141481_10141728	0.15	CLCN4	chloride channel, voltage-sensitive 4	15032	0.23
chr11_62312562_62314176	0.15	RP11-864I4.4		102	0.64
chr3_184056155_184056581	0.15	FAM131A	family with sequence similarity 131, member A	249	0.84
chr7_1600163_1600314	0.15	TMEM184A	transmembrane protein 184A	219	0.92
chr13_23733598_23733940	0.15	ENSG00000207157	.	6944	0.23
chr16_3241653_3241969	0.15	AJ003147.9		3599	0.12
chr5_131593477_131594185	0.15	PDLIM4	PDZ and LIM domain 4	431	0.81
chr1_38259533_38260044	0.15	MANEAL	mannosidase, endo-alpha-like	233	0.86
chr22_30641646_30641949	0.15	RP1-102K2.8		187	0.85
chr6_36567708_36568239	0.15	SRSF3	serine/arginine-rich splicing factor 3	5828	0.16
chr19_56576699_56576850	0.15	ZNF787	zinc finger protein 787	38079	0.1
chr5_137609759_137610630	0.15	GFRA3	GDNF family receptor alpha 3	60	0.96
chr9_117880223_117880437	0.15	TNC	tenascin C	148	0.97
chr17_4902045_4902282	0.15	KIF1C	kinesin family member 1C	914	0.26
chr5_124827830_124828314	0.15	ENSG00000222107	.	141248	0.05
chr17_62971851_62972399	0.15	AMZ2P1	archaelysin family metallopeptidase 2 pseudogene 1	2490	0.23
chr5_139283809_139284341	0.15	NRG2	neuregulin 2	93	0.98
chr7_138720144_138720977	0.15	ZC3HAV1L	zinc finger CCCH-type, antiviral 1-like	215	0.95
chr5_134824456_134824665	0.15	TIFAB	TRAF-interacting protein with forkhead-associated domain, family member B	36471	0.11
chr1_20811158_20811808	0.14	CAMK2N1	calcium/calmodulin-dependent protein kinase II inhibitor 1	1230	0.48
chr16_65157518_65157704	0.14	CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	1343	0.63
chr11_70244216_70245100	0.14	CTTN	cortactin	11	0.53
chr17_9142709_9143234	0.14	RP11-85B7.4		43520	0.15
chr22_18958500_18958651	0.14	DGCR5	DiGeorge syndrome critical region gene 5 (non-protein coding)	479	0.78
chr5_95767628_95767788	0.14	PCSK1	proprotein convertase subtilisin/kexin type 1	156	0.97
chr18_74271196_74271347	0.14	LINC00908	long intergenic non-protein coding RNA 908	30397	0.18
chr1_19282077_19282398	0.14	IFFO2	intermediate filament family orphan 2	45	0.98
chr10_74544262_74544615	0.14	RP11-354E23.5		18120	0.19
chr1_40098862_40099023	0.14	RP1-144F13.3		146	0.66
chr7_158823123_158823874	0.14	ENSG00000231419	.	22386	0.25
chr8_17354234_17354457	0.14	SLC7A2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	252	0.95

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of EGR1_EGR4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0060686	negative regulation of prostatic bud formation(GO:0060686)
0.2	0.5	GO:0010511	regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.1	0.4	GO:0008049	male courtship behavior(GO:0008049)
0.1	0.3	GO:0045198	establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1	0.2	GO:0009405	pathogenesis(GO:0009405)
0.1	0.1	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.1	0.1	GO:0060748	tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.1	0.2	GO:0032808	lacrimal gland development(GO:0032808)
0.1	0.2	GO:0060685	regulation of prostatic bud formation(GO:0060685)
0.1	0.2	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.1	0.2	GO:0010107	potassium ion import(GO:0010107)
0.1	0.2	GO:0043589	skin morphogenesis(GO:0043589)
0.1	0.2	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.1	0.2	GO:0070777	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1	0.1	GO:0060596	mammary placode formation(GO:0060596)
0.1	0.3	GO:0045780	positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.1	0.1	GO:0072110	glomerular mesangial cell proliferation(GO:0072110) regulation of glomerular mesangial cell proliferation(GO:0072124)
0.0	0.1	GO:0016081	synaptic vesicle docking(GO:0016081)
0.0	0.2	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367)
0.0	0.0	GO:0060492	foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) iris morphogenesis(GO:0061072)
0.0	0.0	GO:0072033	renal vesicle formation(GO:0072033)
0.0	0.1	GO:0061364	apoptotic process involved in luteolysis(GO:0061364)
0.0	0.1	GO:0048867	stem cell fate commitment(GO:0048865) stem cell fate determination(GO:0048867)
0.0	0.1	GO:0033087	negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0	0.3	GO:0016540	protein autoprocessing(GO:0016540)
0.0	0.2	GO:0008218	bioluminescence(GO:0008218)
0.0	0.2	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.3	GO:0032331	negative regulation of chondrocyte differentiation(GO:0032331)
0.0	0.4	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.1	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.0	GO:0072239	metanephric glomerulus development(GO:0072224) metanephric glomerulus vasculature development(GO:0072239)
0.0	0.3	GO:0060438	trachea development(GO:0060438)
0.0	0.1	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.1	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.2	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0	0.2	GO:0045992	negative regulation of embryonic development(GO:0045992)
0.0	0.2	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.0	0.2	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.1	GO:0032353	negative regulation of hormone metabolic process(GO:0032351) negative regulation of hormone biosynthetic process(GO:0032353)
0.0	0.3	GO:0021955	central nervous system neuron axonogenesis(GO:0021955)
0.0	0.1	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.1	GO:0072047	proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.0	0.1	GO:1900121	regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.1	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.0	GO:0090185	negative regulation of kidney development(GO:0090185)
0.0	0.1	GO:0007144	female meiosis I(GO:0007144)
0.0	0.1	GO:0007207	phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0	0.3	GO:0042249	establishment of planar polarity of embryonic epithelium(GO:0042249)
0.0	0.1	GO:0034201	response to oleic acid(GO:0034201)
0.0	0.1	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.0	0.2	GO:0033240	positive regulation of cellular amine metabolic process(GO:0033240)
0.0	0.1	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.1	GO:0060291	long-term synaptic potentiation(GO:0060291)
0.0	0.2	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.2	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.2	GO:0015802	basic amino acid transport(GO:0015802)
0.0	0.0	GO:0060435	bronchiole development(GO:0060435)
0.0	0.1	GO:0060992	response to fungicide(GO:0060992)
0.0	0.1	GO:0002085	inhibition of neuroepithelial cell differentiation(GO:0002085)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.1	GO:0010996	response to auditory stimulus(GO:0010996)
0.0	0.1	GO:0010658	striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0	0.1	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0	0.3	GO:1901678	iron coordination entity transport(GO:1901678)
0.0	0.3	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.1	GO:0034653	diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0	0.2	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.0	0.1	GO:0090218	positive regulation of lipid kinase activity(GO:0090218)
0.0	0.0	GO:0002068	glandular epithelial cell development(GO:0002068)
0.0	0.0	GO:1901722	cell proliferation involved in metanephros development(GO:0072203) regulation of cell proliferation involved in kidney development(GO:1901722)
0.0	0.0	GO:0003179	heart valve development(GO:0003170) heart valve morphogenesis(GO:0003179)
0.0	0.1	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.1	GO:1901890	positive regulation of focal adhesion assembly(GO:0051894) positive regulation of cell junction assembly(GO:1901890) positive regulation of adherens junction organization(GO:1903393)
0.0	0.1	GO:0001993	regulation of systemic arterial blood pressure by norepinephrine-epinephrine(GO:0001993) positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321)
0.0	0.1	GO:0051045	negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0	0.1	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.0	GO:0060737	prostate gland morphogenetic growth(GO:0060737)
0.0	0.3	GO:0035329	hippo signaling(GO:0035329)
0.0	0.1	GO:0060662	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0	0.2	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.1	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.3	GO:0042745	circadian sleep/wake cycle(GO:0042745)
0.0	0.1	GO:0003323	type B pancreatic cell development(GO:0003323)
0.0	0.1	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.0	0.1	GO:0055075	potassium ion homeostasis(GO:0055075)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0042415	norepinephrine metabolic process(GO:0042415)
0.0	0.0	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.0	0.1	GO:0009296	obsolete flagellum assembly(GO:0009296)
0.0	0.0	GO:0048505	regulation of development, heterochronic(GO:0040034) regulation of timing of cell differentiation(GO:0048505)
0.0	0.1	GO:0010890	positive regulation of sequestering of triglyceride(GO:0010890)
0.0	0.1	GO:0046339	diacylglycerol metabolic process(GO:0046339)
0.0	0.3	GO:1902749	regulation of G2/M transition of mitotic cell cycle(GO:0010389) regulation of cell cycle G2/M phase transition(GO:1902749)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.1	GO:0043457	regulation of cellular respiration(GO:0043457)
0.0	0.3	GO:0006541	glutamine metabolic process(GO:0006541)
0.0	0.1	GO:0042501	serine phosphorylation of STAT protein(GO:0042501)
0.0	0.1	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.0	0.0	GO:0060033	Mullerian duct regression(GO:0001880) anatomical structure regression(GO:0060033)
0.0	0.1	GO:0033683	nucleotide-excision repair, DNA incision(GO:0033683)
0.0	0.1	GO:0021978	telencephalon regionalization(GO:0021978)
0.0	0.1	GO:0003091	renal water homeostasis(GO:0003091)
0.0	0.0	GO:0050942	positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.0	0.2	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.0	0.1	GO:0050955	thermoception(GO:0050955)
0.0	0.0	GO:0051891	positive regulation of cardioblast differentiation(GO:0051891) positive regulation of cardiocyte differentiation(GO:1905209)
0.0	0.1	GO:0015742	alpha-ketoglutarate transport(GO:0015742)
0.0	0.0	GO:0090036	regulation of protein kinase C signaling(GO:0090036) positive regulation of protein kinase C signaling(GO:0090037)
0.0	0.1	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.1	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.1	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.1	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.1	GO:0033688	regulation of osteoblast proliferation(GO:0033688)
0.0	0.0	GO:0019614	phenol-containing compound catabolic process(GO:0019336) catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0	0.1	GO:0070141	response to UV-A(GO:0070141)
0.0	0.1	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.2	GO:0048635	negative regulation of muscle organ development(GO:0048635)
0.0	0.4	GO:0007566	embryo implantation(GO:0007566)
0.0	0.1	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.0	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.1	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.0	GO:0060913	cardiac cell fate determination(GO:0060913)
0.0	0.1	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.1	GO:0021984	adenohypophysis development(GO:0021984)
0.0	0.0	GO:0009996	negative regulation of cell fate specification(GO:0009996)
0.0	0.1	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0	0.1	GO:0032836	glomerular basement membrane development(GO:0032836)
0.0	0.1	GO:0060317	cardiac epithelial to mesenchymal transition(GO:0060317)
0.0	0.0	GO:0010661	positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0	0.2	GO:0031069	hair follicle morphogenesis(GO:0031069)
0.0	0.0	GO:0060976	coronary vasculature development(GO:0060976)
0.0	0.0	GO:0014850	response to muscle activity(GO:0014850)
0.0	0.0	GO:0015803	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0	0.0	GO:0097501	detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0	0.1	GO:0071599	otic vesicle formation(GO:0030916) otic vesicle development(GO:0071599) otic vesicle morphogenesis(GO:0071600)
0.0	0.1	GO:0034629	cellular protein complex localization(GO:0034629)
0.0	0.0	GO:0071503	response to heparin(GO:0071503)
0.0	0.0	GO:0048266	behavioral response to pain(GO:0048266)
0.0	0.0	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0	0.0	GO:0048799	organ maturation(GO:0048799) bone maturation(GO:0070977)
0.0	0.1	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.0	GO:0060684	epithelial-mesenchymal cell signaling(GO:0060684)
0.0	0.0	GO:0022605	oogenesis stage(GO:0022605)
0.0	0.0	GO:1904251	regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.0	0.1	GO:0002090	regulation of receptor internalization(GO:0002090)
0.0	0.1	GO:0030828	positive regulation of cGMP biosynthetic process(GO:0030828)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.2	GO:0050766	positive regulation of phagocytosis(GO:0050766)
0.0	0.0	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.2	GO:0009268	response to pH(GO:0009268)
0.0	0.1	GO:0050435	beta-amyloid metabolic process(GO:0050435)
0.0	0.0	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.1	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.0	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.0	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.0	GO:0046877	regulation of saliva secretion(GO:0046877)
0.0	0.1	GO:0002634	regulation of germinal center formation(GO:0002634)
0.0	0.0	GO:0061299	retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0	0.0	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0	0.0	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.0	GO:0006551	leucine metabolic process(GO:0006551)
0.0	0.0	GO:0090598	male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0	0.1	GO:0010718	positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.0	0.2	GO:0034394	protein localization to cell surface(GO:0034394)
0.0	0.0	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.0	0.1	GO:0030219	megakaryocyte differentiation(GO:0030219)
0.0	0.0	GO:0010159	specification of organ position(GO:0010159)
0.0	0.0	GO:0043092	L-amino acid import(GO:0043092)
0.0	0.0	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.0	GO:0032714	negative regulation of interleukin-5 production(GO:0032714)
0.0	0.0	GO:0021932	hindbrain radial glia guided cell migration(GO:0021932)
0.0	0.1	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)
0.0	0.0	GO:0014808	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880) release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0014808) calcium ion transport from endoplasmic reticulum to cytosol(GO:1903514)
0.0	0.0	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.1	GO:0048841	regulation of axon extension involved in axon guidance(GO:0048841)
0.0	0.0	GO:0090205	positive regulation of cholesterol metabolic process(GO:0090205)
0.0	0.0	GO:0019227	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0	0.0	GO:0021570	rhombomere 4 development(GO:0021570)
0.0	0.0	GO:0072048	pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048) pattern specification involved in metanephros development(GO:0072268)
0.0	0.0	GO:0034723	DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.1	GO:0009437	amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.0	0.0	GO:0001757	somite specification(GO:0001757)
0.0	0.0	GO:0045002	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0	0.0	GO:0002326	B cell lineage commitment(GO:0002326)
0.0	0.0	GO:0035625	receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625)
0.0	0.0	GO:0071043	CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0	0.0	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.1	GO:0042596	behavioral fear response(GO:0001662) fear response(GO:0042596)
0.0	0.1	GO:0006688	glycosphingolipid biosynthetic process(GO:0006688)
0.0	0.0	GO:0042637	catagen(GO:0042637)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0048268	clathrin coat assembly(GO:0048268)
0.0	0.2	GO:0016486	peptide hormone processing(GO:0016486)
0.0	0.0	GO:0046548	retinal rod cell development(GO:0046548)
0.0	0.0	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.0	GO:0071542	dopaminergic neuron differentiation(GO:0071542)
0.0	0.0	GO:0021819	layer formation in cerebral cortex(GO:0021819)
0.0	0.0	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.0	GO:0060068	vagina development(GO:0060068)
0.0	0.0	GO:0035058	nonmotile primary cilium assembly(GO:0035058)
0.0	0.0	GO:0048935	peripheral nervous system neuron development(GO:0048935)
0.0	0.3	GO:0006493	protein O-linked glycosylation(GO:0006493)
0.0	0.2	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.0	GO:0042178	xenobiotic catabolic process(GO:0042178)
0.0	0.0	GO:0030210	heparin biosynthetic process(GO:0030210)
0.0	0.0	GO:0061043	vascular wound healing(GO:0061042) regulation of vascular wound healing(GO:0061043)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.1	0.4	GO:0005606	laminin-1 complex(GO:0005606)
0.1	0.2	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.2	GO:0042584	chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.0	0.1	GO:0032449	CBM complex(GO:0032449)
0.0	0.2	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	0.1	GO:0032591	dendritic spine membrane(GO:0032591)
0.0	0.1	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0	0.1	GO:0016600	flotillin complex(GO:0016600)
0.0	0.1	GO:0071942	XPC complex(GO:0071942)
0.0	0.1	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.3	GO:0071565	nBAF complex(GO:0071565)
0.0	0.4	GO:0005922	connexon complex(GO:0005922)
0.0	0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.1	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0	0.1	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.1	GO:0032279	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	0.0	GO:0032059	bleb(GO:0032059)
0.0	0.1	GO:0005652	nuclear lamina(GO:0005652)
0.0	0.1	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.2	GO:0090665	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0	0.3	GO:0005581	collagen trimer(GO:0005581)
0.0	0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.1	GO:0031941	filamentous actin(GO:0031941)
0.0	0.1	GO:0010369	chromocenter(GO:0010369)
0.0	0.2	GO:0030130	clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0	0.1	GO:0031428	box C/D snoRNP complex(GO:0031428)
0.0	0.1	GO:0031430	M band(GO:0031430)
0.0	0.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.1	GO:0032156	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.1	GO:0030125	clathrin vesicle coat(GO:0030125)
0.0	0.1	GO:0031512	motile primary cilium(GO:0031512)
0.0	0.4	GO:0043679	axon terminus(GO:0043679)
0.0	0.0	GO:0070852	cell body fiber(GO:0070852)
0.0	0.1	GO:0043205	fibril(GO:0043205)
0.0	0.1	GO:0032589	neuron projection membrane(GO:0032589)
0.0	0.2	GO:0043204	perikaryon(GO:0043204)
0.0	0.2	GO:0016460	myosin II complex(GO:0016460)
0.0	0.0	GO:0043260	laminin-11 complex(GO:0043260)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0005113	patched binding(GO:0005113)
0.1	1.0	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.1	0.5	GO:0005110	frizzled-2 binding(GO:0005110)
0.1	0.2	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.2	GO:0050698	proteoglycan sulfotransferase activity(GO:0050698)
0.1	0.2	GO:0043559	insulin binding(GO:0043559)
0.1	0.2	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.1	0.2	GO:0008502	melatonin receptor activity(GO:0008502)
0.1	0.2	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.1	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.1	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.1	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.3	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.0	0.5	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.1	GO:0070215	obsolete MDM2 binding(GO:0070215)
0.0	0.4	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.1	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.2	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0	0.2	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.2	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0035198	miRNA binding(GO:0035198)
0.0	0.1	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0	0.3	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.1	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.3	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.1	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.2	GO:0034416	bisphosphoglycerate phosphatase activity(GO:0034416)
0.0	0.2	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.2	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0016416	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0	0.1	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0	0.2	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)
0.0	0.1	GO:0004500	dopamine beta-monooxygenase activity(GO:0004500)
0.0	0.1	GO:0099604	calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0	0.1	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.1	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.1	GO:0044390	ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0	0.1	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.3	GO:0005234	extracellular-glutamate-gated ion channel activity(GO:0005234)
0.0	0.1	GO:0030506	ankyrin binding(GO:0030506)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.1	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.1	GO:0005148	prolactin receptor binding(GO:0005148)
0.0	0.0	GO:0099602	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0	0.1	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.1	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.1	GO:0030151	molybdenum ion binding(GO:0030151)
0.0	0.1	GO:0031404	chloride ion binding(GO:0031404)
0.0	0.1	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.2	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	0.1	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.2	GO:0046625	sphingolipid binding(GO:0046625)
0.0	0.1	GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.2	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.0	0.1	GO:0004142	diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0	0.1	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.1	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	0.1	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.1	GO:0015254	glycerol channel activity(GO:0015254)
0.0	0.1	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.1	GO:0005112	Notch binding(GO:0005112)
0.0	0.4	GO:0015459	potassium channel regulator activity(GO:0015459)
0.0	0.0	GO:0034711	inhibin binding(GO:0034711)
0.0	0.3	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0004457	lactate dehydrogenase activity(GO:0004457)
0.0	0.1	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.2	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.0	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.0	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.0	0.0	GO:0034187	obsolete apolipoprotein E binding(GO:0034187)
0.0	0.1	GO:0050780	dopamine receptor binding(GO:0050780)
0.0	0.0	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.1	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.1	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.1	GO:0016742	hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0	0.0	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.2	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.1	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.1	GO:0048185	activin binding(GO:0048185)
0.0	0.0	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0	0.0	GO:0008061	chitin binding(GO:0008061)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.0	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.1	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0	0.1	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	0.0	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.0	GO:0032554	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.1	GO:0030553	cGMP binding(GO:0030553)
0.0	0.2	GO:0005109	frizzled binding(GO:0005109)
0.0	0.0	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.1	GO:0004675	transmembrane receptor protein serine/threonine kinase activity(GO:0004675)
0.0	0.0	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	0.1	GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.0	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.0	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.0	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.0	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894)
0.0	0.0	GO:0099528	dopamine neurotransmitter receptor activity(GO:0004952) G-protein coupled neurotransmitter receptor activity(GO:0099528)
0.0	0.2	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	0.0	GO:0005346	purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.0	0.0	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.1	GO:0034483	heparan sulfate sulfotransferase activity(GO:0034483)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.0	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.0	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.0	0.0	GO:0016847	1-aminocyclopropane-1-carboxylate synthase activity(GO:0016847)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.6	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.7	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.3	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.3	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.3	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.1	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.5	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.7	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.2	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.2	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.0	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.2	PID VEGFR1 PATHWAY	VEGFR1 specific signals
0.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.4	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.0	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.0	PID S1P S1P1 PATHWAY	S1P1 pathway
0.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.1	REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.1	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.4	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.3	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.4	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.7	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.3	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.3	REACTOME FGFR1 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR1 ligand binding and activation
0.4	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.2	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.6	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.2	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.2	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.2	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.3	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels
0.0	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.2	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR4 ligand binding and activation
0.2	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
0.3	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.2	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
1.1	REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	Genes involved in Downstream signal transduction
0.1	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation
0.2	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.2	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.1	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.3	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.2	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.2	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.6	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.9	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.1	REACTOME SIGNALING BY PDGF	Genes involved in Signaling by PDGF