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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for EGR3_EGR2

Z-value: 0.55

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Transcription factors associated with EGR3_EGR2

Gene Symbol Gene ID Gene Info
EGR3
ENSG00000179388.8 early growth response 3
EGR2
ENSG00000122877.9 early growth response 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr10_64576967_64577230EGR29720.568878-0.665.5e-02Click!
chr10_64577478_64577629EGR213740.440127-0.617.9e-02Click!
chr10_64645936_64646087EGR2670840.1118740.491.8e-01Click!
chr10_64577295_64577446EGR212440.474933-0.491.8e-01Click!
chr10_64576654_64576951EGR26760.707493-0.462.2e-01Click!
chr8_22552129_22552945EGR317220.257808-0.674.8e-02Click!
chr8_22551556_22552015EGR39700.435958-0.608.7e-02Click!
chr8_22572743_22572905EGR3220090.1249070.589.8e-02Click!
chr8_22551057_22551465EGR34460.740990-0.581.0e-01Click!
chr8_22576706_22576857EGR3259660.121391-0.541.4e-01Click!

Activity of the EGR3_EGR2 motif across conditions

Conditions sorted by the z-value of the EGR3_EGR2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr20_49347136_49348386 0.37 PARD6B
 par-6 family cell polarity regulator beta
 320
 0.89
chr7_12755011_12755366 0.37 ENSG00000199470
 .
 14674
 0.23
chr21_45139141_45140358 0.34 PDXK
 pyridoxal (pyridoxine, vitamin B6) kinase
 756
 0.66
chr9_100069234_100069583 0.34 CCDC180
 coiled-coil domain containing 180
 533
 0.83
chr4_150999769_151000790 0.33 DCLK2
 doublecortin-like kinase 2
 99
 0.98
chr5_63461313_63462499 0.30 RNF180
 ring finger protein 180
 83
 0.99
chr2_242497891_242499073 0.30 BOK-AS1
 BOK antisense RNA 1
 90
 0.79
chr1_9189517_9189890 0.29 GPR157
 G protein-coupled receptor 157
 474
 0.79
chr1_33336564_33337052 0.29 FNDC5
 fibronectin type III domain containing 5
 394
 0.8
chr19_15311959_15312270 0.28 NOTCH3
 notch 3
 322
 0.87
chr4_121842864_121843514 0.27 PRDM5
 PR domain containing 5
 815
 0.75
chr19_56988243_56988602 0.26 ZNF667
 zinc finger protein 667
 65
 0.96
chr1_86042054_86042529 0.26 DDAH1
 dimethylarginine dimethylaminohydrolase 1
 1642
 0.36
chr1_159750747_159751482 0.26 DUSP23
 dual specificity phosphatase 23
 321
 0.85
chr1_244012088_244013269 0.25 AKT3
 v-akt murine thymoma viral oncogene homolog 3
 752
 0.75
chr17_57408824_57410302 0.25 YPEL2
 yippee-like 2 (Drosophila)
 500
 0.78
chr14_91790220_91790791 0.24 ENSG00000265856
 .
 9552
 0.21
chr5_153990189_153990659 0.24 ENSG00000264760
 .
 14792
 0.21
chr17_8602020_8602357 0.24 CCDC42
 coiled-coil domain containing 42
 45917
 0.12
chr2_946282_946607 0.23 SNTG2
 syntrophin, gamma 2
 110
 0.86
chr16_402538_402771 0.23 AXIN1
 axin 1
 5
 0.96
chr15_80696207_80696642 0.22 ARNT2
 aryl-hydrocarbon receptor nuclear translocator 2
 269
 0.71
chr3_196729783_196730213 0.22 MFI2-AS1
 MFI2 antisense RNA 1
 5
 0.97
chr11_64512499_64513555 0.21 RASGRP2
 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
 99
 0.95
chr10_49812568_49813319 0.21 ARHGAP22
 Rho GTPase activating protein 22
 54
 0.98
chr4_3709787_3709938 0.21 ADRA2C
 adrenoceptor alpha 2C
 58213
 0.14
chr6_28175094_28175274 0.21 ZSCAN9
 zinc finger and SCAN domain containing 9
 17480
 0.12
chr1_31380173_31380807 0.21 SDC3
 syndecan 3
 1118
 0.44
chr2_177502027_177502943 0.20 ENSG00000252027
 .
 26919
 0.25
chr12_63211718_63211943 0.19 ENSG00000200296
 .
 32851
 0.21
chr7_127672748_127672947 0.19 LRRC4
 leucine rich repeat containing 4
 687
 0.76
chr4_79472640_79473562 0.19 ANXA3
 annexin A3
 20
 0.99
chr8_145925356_145925968 0.19 AF186192.5
5257
 0.15
chr1_3816010_3816785 0.19 C1orf174
 chromosome 1 open reading frame 174
 452
 0.8
chr12_63025567_63026419 0.18 ENSG00000238475
 .
 18962
 0.14
chr2_26624476_26625174 0.18 DRC1
 dynein regulatory complex subunit 1 homolog (Chlamydomonas)
 41
 0.98
chr1_1370771_1371229 0.18 VWA1
 von Willebrand factor A domain containing 1
 51
 0.93
chr12_6937518_6938631 0.18 LEPREL2
 leprecan-like 2
 502
 0.55
chr1_205512616_205512824 0.18 ENSG00000253097
 .
 23124
 0.13
chr16_88857124_88857275 0.18 PIEZO1
 piezo-type mechanosensitive ion channel component 1
 5580
 0.1
chr4_14864468_14865022 0.18 CPEB2
 cytoplasmic polyadenylation element binding protein 2
 139553
 0.05
chr6_146919852_146920086 0.17 ADGB
 androglobin
 132
 0.97
chr3_37903731_37903951 0.17 CTDSPL
 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
 176
 0.83
chr16_402920_403077 0.17 AXIN1
 axin 1
 339
 0.79
chr6_166076326_166076646 0.17 PDE10A
 phosphodiesterase 10A
 898
 0.71
chr7_100081068_100081412 0.17 ENSG00000266372
 .
 226
 0.55
chr7_28450564_28450725 0.17 CREB5
 cAMP responsive element binding protein 5
 1500
 0.57
chr4_134072879_134073697 0.17 PCDH10
 protocadherin 10
 2818
 0.44
chr9_98279334_98279613 0.17 PTCH1
 patched 1
 134
 0.95
chr5_158636669_158637140 0.16 CTB-11I22.1
25
 0.66
chr2_8818889_8820001 0.16 AC011747.7
259
 0.7
chr3_141379125_141379497 0.16 RNF7
 ring finger protein 7
 77735
 0.09
chr2_167350846_167351007 0.16 SCN7A
 sodium channel, voltage-gated, type VII, alpha subunit
 169
 0.97
chr7_193532_193958 0.16 AC093627.12
435
 0.67
chr18_2848081_2848464 0.16 EMILIN2
 elastin microfibril interfacer 2
 1244
 0.42
chr19_38714929_38715117 0.15 DPF1
 D4, zinc and double PHD fingers family 1
 133
 0.92
chr1_227058397_227059047 0.15 PSEN2
 presenilin 2 (Alzheimer disease 4)
 243
 0.94
chr17_7905804_7906020 0.15 GUCY2D
 guanylate cyclase 2D, membrane (retina-specific)
 0
 0.96
chr18_12287984_12288154 0.15 ENSG00000199702
 .
 16124
 0.16
chr19_38878742_38879193 0.15 SPRED3
 sprouty-related, EVH1 domain containing 3
 94
 0.68
chr9_100849786_100850488 0.15 TRIM14
 tripartite motif containing 14
 4706
 0.2
chr3_46924906_46925224 0.15 PTH1R
 parathyroid hormone 1 receptor
 218
 0.88
chr1_19600410_19601051 0.15 AKR7L
 aldo-keto reductase family 7-like
 162
 0.92
chr17_60885608_60885921 0.14 MARCH10
 membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
 59
 0.98
chr10_13500683_13500834 0.14 BEND7
 BEN domain containing 7
 22315
 0.16
chr1_200003972_200004421 0.14 NR5A2
 nuclear receptor subfamily 5, group A, member 2
 7185
 0.18
chr18_32073627_32073820 0.14 DTNA
 dystrobrevin, alpha
 144
 0.98
chr2_27717607_27718081 0.14 FNDC4
 fibronectin type III domain containing 4
 268
 0.82
chr19_15442836_15443133 0.13 BRD4
 bromodomain containing 4
 266
 0.91
chr8_1921192_1922084 0.13 KBTBD11
 kelch repeat and BTB (POZ) domain containing 11
 406
 0.9
chr4_187476503_187476829 0.13 MTNR1A
 melatonin receptor 1A
 55
 0.7
chr4_55096373_55096991 0.13 PDGFRA
 platelet-derived growth factor receptor, alpha polypeptide
 193
 0.97
chr19_23258281_23258533 0.13 ZNF730
 zinc finger protein 730
 395
 0.9
chr22_20003723_20004755 0.13 ARVCF
 armadillo repeat gene deleted in velocardiofacial syndrome
 92
 0.75
chr10_103589679_103590635 0.13 KCNIP2
 Kv channel interacting protein 2
 38
 0.97
chr9_115875359_115875603 0.13 SLC31A2
 solute carrier family 31 (copper transporter), member 2
 37741
 0.15
chr2_103235205_103235939 0.13 SLC9A2
 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
 594
 0.82
chr2_105489505_105490071 0.13 LINC01159
 long intergenic non-protein coding RNA 1159
 735
 0.58
chrX_21958323_21959013 0.13 SMS
 spermine synthase
 23
 0.98
chr10_116503730_116503881 0.13 ABLIM1
 actin binding LIM protein 1
 59391
 0.13
chr17_15653076_15653227 0.13 AC005324.6
645
 0.65
chr6_166721057_166722024 0.13 PRR18
 proline rich 18
 331
 0.9
chr11_118478413_118479735 0.13 PHLDB1
 pleckstrin homology-like domain, family B, member 1
 716
 0.54
chrX_37544746_37545007 0.13 XK
 X-linked Kx blood group (McLeod syndrome)
 136
 0.98
chr19_36207272_36208543 0.13 KMT2B
 Histone-lysine N-methyltransferase 2B
 1014
 0.26
chr21_40032373_40032758 0.13 ERG
 v-ets avian erythroblastosis virus E26 oncogene homolog
 26
 0.99
chr4_108745530_108746004 0.12 SGMS2
 sphingomyelin synthase 2
 48
 0.98
chr9_115873523_115873775 0.12 SLC31A2
 solute carrier family 31 (copper transporter), member 2
 39573
 0.15
chr16_88219567_88219948 0.12 BANP
 BTG3 associated nuclear protein
 216133
 0.02
chr11_57282891_57283496 0.12 SLC43A1
 solute carrier family 43 (amino acid system L transporter), member 1
 34
 0.95
chr16_88449218_88449497 0.12 ZNF469
 zinc finger protein 469
 44522
 0.14
chr20_32899126_32899277 0.12 AHCY
 adenosylhomocysteinase
 407
 0.81
chr14_85999757_86000024 0.12 FLRT2
 fibronectin leucine rich transmembrane protein 2
 3318
 0.3
chrX_39949292_39950247 0.12 BCOR
 BCL6 corepressor
 6887
 0.33
chrX_39964334_39965624 0.12 BCOR
 BCL6 corepressor
 8323
 0.32
chr9_130639317_130639975 0.12 AK1
 adenylate kinase 1
 376
 0.71
chr8_61821706_61823076 0.12 RP11-33I11.2
100226
 0.08
chr6_762027_762197 0.12 EXOC2
 exocyst complex component 2
 68995
 0.13
chr12_29936821_29937292 0.12 TMTC1
 transmembrane and tetratricopeptide repeat containing 1
 226
 0.96
chr4_186130212_186131033 0.12 KIAA1430
 KIAA1430
 36
 0.92
chr17_18061433_18061699 0.11 MYO15A
 myosin XVA
 56
 0.96
chr11_122311916_122312418 0.11 ENSG00000252776
 .
 7751
 0.23
chr3_187769593_187769744 0.11 LPP
 LIM domain containing preferred translocation partner in lipoma
 101404
 0.07
chr2_99757819_99758492 0.11 C2ORF15
 Uncharacterized protein C2orf15
 58
 0.58
chr12_75728365_75728595 0.11 GLIPR1L1
 GLI pathogenesis-related 1 like 1
 17
 0.98
chr7_29846053_29846716 0.11 WIPF3
 WAS/WASL interacting protein family, member 3
 282
 0.94
chr11_61485680_61486023 0.11 MYRF
 myelin regulatory factor
 34270
 0.11
chr19_10982465_10983821 0.11 CARM1
 coactivator-associated arginine methyltransferase 1
 764
 0.53
chr20_30196082_30196710 0.11 ENSG00000264395
 .
 1407
 0.28
chr7_19152184_19152434 0.11 AC003986.6
212
 0.92
chr12_54762715_54762975 0.11 GPR84
 G protein-coupled receptor 84
 4574
 0.1
chr9_132382776_132383013 0.11 C9orf50
 chromosome 9 open reading frame 50
 161
 0.92
chr9_17579467_17579684 0.11 SH3GL2
 SH3-domain GRB2-like 2
 454
 0.91
chr14_23706832_23707104 0.11 C14orf164
 chromosome 14 open reading frame 164
 2587
 0.16
chr22_50919615_50920637 0.11 ADM2
 adrenomedullin 2
 27
 0.94
chrX_138774003_138774873 0.11 MCF2
 MCF.2 cell line derived transforming sequence
 123
 0.97
chr6_133089264_133089460 0.11 VNN2
 vanin 2
 4764
 0.14
chr11_13690295_13691391 0.11 FAR1-IT1
 FAR1 intronic transcript 1 (non-protein coding)
 31
 0.92
chr16_29231551_29231794 0.11 RP11-231C14.6
91999
 0.06
chr15_40697977_40698740 0.11 IVD
 isovaleryl-CoA dehydrogenase
 83
 0.94
chr1_225839301_225840394 0.11 ENAH
 enabled homolog (Drosophila)
 571
 0.78
chr19_49866897_49867069 0.11 DKKL1
 dickkopf-like 1
 4
 0.93
chr2_129166329_129166512 0.10 ENSG00000238379
 .
 36352
 0.19
chrX_48814395_48814616 0.10 OTUD5
 OTU domain containing 5
 54
 0.94
chr7_145813028_145813349 0.10 CNTNAP2
 contactin associated protein-like 2
 265
 0.94
chr1_95286002_95286302 0.10 SLC44A3
 solute carrier family 44, member 3
 25
 0.98
chr3_39093427_39094272 0.10 WDR48
 WD repeat domain 48
 57
 0.97
chr16_54318004_54318459 0.10 IRX3
 iroquois homeobox 3
 1536
 0.47
chr8_637614_638228 0.10 ERICH1
 glutamate-rich 1
 14264
 0.22
chr6_1619961_1620659 0.10 FOXC1
 forkhead box C1
 9629
 0.3
chr10_81194638_81194815 0.10 ZCCHC24
 zinc finger, CCHC domain containing 24
 9249
 0.21
chr18_56029142_56029527 0.10 RP11-845C23.2
9464
 0.19
chr1_27320396_27320765 0.10 TRNP1
 TMF1-regulated nuclear protein 1
 230
 0.91
chr8_125673018_125673304 0.10 MTSS1
 metastasis suppressor 1
 66696
 0.11
chr7_94025506_94025990 0.10 COL1A2
 collagen, type I, alpha 2
 1875
 0.46
chr7_93520142_93520396 0.10 TFPI2
 tissue factor pathway inhibitor 2
 34
 0.5
chr12_111843881_111845308 0.10 SH2B3
 SH2B adaptor protein 3
 842
 0.62
chrX_40035041_40035983 0.10 BCOR
 BCL6 corepressor
 1061
 0.68
chrX_117861722_117862389 0.10 IL13RA1
 interleukin 13 receptor, alpha 1
 490
 0.84
chrX_101186111_101187162 0.10 ZMAT1
 zinc finger, matrin-type 1
 101
 0.97
chr21_37529152_37530122 0.10 DOPEY2
 dopey family member 2
 557
 0.57
chr15_100272658_100273585 0.10 LYSMD4
 LysM, putative peptidoglycan-binding, domain containing 4
 423
 0.79
chr6_166421798_166421999 0.10 ENSG00000252196
 .
 66069
 0.12
chr6_164203543_164203694 0.09 ENSG00000266128
 .
 57975
 0.17
chr21_47401799_47402727 0.09 COL6A1
 collagen, type VI, alpha 1
 612
 0.75
chr19_48996311_48996470 0.09 LMTK3
 lemur tyrosine kinase 3
 18671
 0.09
chr1_47184939_47185223 0.09 EFCAB14
 EF-hand calcium binding domain 14
 257
 0.91
chr8_71005594_71005799 0.09 ENSG00000212473
 .
 15429
 0.2
chr2_96012468_96013004 0.09 KCNIP3
 Kv channel interacting protein 3, calsenilin
 260
 0.94
chr2_204193085_204194072 0.09 ABI2
 abl-interactor 2
 371
 0.48
chr17_13505362_13505866 0.09 HS3ST3A1
 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
 370
 0.91
chr10_133793290_133793613 0.09 BNIP3
 BCL2/adenovirus E1B 19kDa interacting protein 3
 1976
 0.41
chrX_134556811_134556962 0.09 ENSG00000201440
 .
 5324
 0.25
chr3_169376087_169376335 0.09 MECOM
 MDS1 and EVI1 complex locus
 4967
 0.2
chr22_39377484_39377635 0.09 APOBEC3B
 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
 793
 0.51
chr5_102594979_102595784 0.09 C5orf30
 chromosome 5 open reading frame 30
 256
 0.94
chr15_33010201_33010591 0.09 GREM1
 gremlin 1, DAN family BMP antagonist
 191
 0.95
chr9_140335891_140336276 0.09 ENTPD8
 ectonucleoside triphosphate diphosphohydrolase 8
 182
 0.91
chr19_56159091_56160130 0.09 CCDC106
 coiled-coil domain containing 106
 11
 0.93
chr22_29469254_29470042 0.09 KREMEN1
 kringle containing transmembrane protein 1
 529
 0.72
chr7_97912986_97913801 0.09 BRI3
 brain protein I3
 2406
 0.26
chr10_81206278_81206598 0.09 ZCCHC24
 zinc finger, CCHC domain containing 24
 1055
 0.56
chr1_205648469_205649627 0.09 SLC45A3
 solute carrier family 45, member 3
 539
 0.74
chr3_170075598_170076731 0.09 SKIL
 SKI-like oncogene
 642
 0.78
chr10_38893897_38894048 0.09 LINC00999
 long intergenic non-protein coding RNA 999
 176898
 0.03
chr7_107641976_107642307 0.09 LAMB1
 laminin, beta 1
 331
 0.84
chr9_15510511_15510905 0.09 PSIP1
 PC4 and SFRS1 interacting protein 1
 281
 0.9
chr7_128828157_128829026 0.09 SMO
 smoothened, frizzled family receptor
 122
 0.95
chr8_102300419_102300649 0.09 ENSG00000239115
 .
 19061
 0.24
chr11_70244216_70245100 0.09 CTTN
 cortactin
 11
 0.53
chr11_8788560_8788716 0.09 ST5
 suppression of tumorigenicity 5
 379
 0.79
chr2_232545912_232546437 0.09 MGC4771
25447
 0.14
chr20_62526165_62526370 0.09 DNAJC5
 DnaJ (Hsp40) homolog, subfamily C, member 5
 251
 0.8
chr12_49392080_49393040 0.09 RP11-386G11.5
379
 0.49
chr2_149894818_149895436 0.08 LYPD6B
 LY6/PLAUR domain containing 6B
 105
 0.98
chr1_232725835_232725986 0.08 SIPA1L2
 signal-induced proliferation-associated 1 like 2
 28606
 0.25
chr5_16935133_16935934 0.08 MYO10
 myosin X
 514
 0.81
chr18_6729547_6730123 0.08 ARHGAP28
 Rho GTPase activating protein 28
 14
 0.5
chr3_181413371_181413945 0.08 SOX2-OT
 SOX2 overlapping transcript (non-protein coding)
 3623
 0.29
chr3_50232089_50232320 0.08 GNAT1
 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
 2099
 0.19
chr9_110228052_110228707 0.08 ENSG00000199905
 .
 9041
 0.21
chr10_19777738_19777947 0.08 MALRD1
 MAM and LDL receptor class A domain containing 1
 181
 0.97
chr5_134824456_134824665 0.08 TIFAB
 TRAF-interacting protein with forkhead-associated domain, family member B
 36471
 0.11
chr10_123914231_123914382 0.08 TACC2
 transforming, acidic coiled-coil containing protein 2
 8635
 0.28
chr5_176924144_176924598 0.08 PDLIM7
 PDZ and LIM domain 7 (enigma)
 191
 0.88
chr11_67070981_67071360 0.08 SSH3
 slingshot protein phosphatase 3
 73
 0.95
chr5_177894971_177895186 0.08 CTB-26E19.1
24983
 0.2
chr14_103673729_103674048 0.08 ENSG00000239117
 .
 4365
 0.24
chr6_135592009_135592160 0.08 RP1-32B1.4
10950
 0.18
chr6_157610005_157610158 0.08 ENSG00000252609
 .
 102350
 0.07
chr10_110225810_110226152 0.08 ENSG00000222436
 .
 475087
 0.01
chr22_35748941_35749092 0.08 ENSG00000266320
 .
 17383
 0.15
chr5_78985270_78986298 0.08 CMYA5
 cardiomyopathy associated 5
 84
 0.98
chr2_74881397_74882034 0.08 SEMA4F
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
 277
 0.89
chr16_78540334_78540585 0.08 RP11-264L1.4
6
 0.99
chr18_25758066_25758464 0.08 CDH2
 cadherin 2, type 1, N-cadherin (neuronal)
 855
 0.77
chr5_101632211_101632449 0.08 SLCO4C1
 solute carrier organic anion transporter family, member 4C1
 77
 0.98
chr19_4473895_4474732 0.08 HDGFRP2
 Hepatoma-derived growth factor-related protein 2
 576
 0.53
chr10_74544262_74544615 0.08 RP11-354E23.5
18120
 0.19
chr22_42835920_42836170 0.08 NFAM1
 NFAT activating protein with ITAM motif 1
 7644
 0.19

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of EGR3_EGR2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0001743 optic placode formation(GO:0001743)
0.1 0.2 GO:0042819 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.1 0.2 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.2 GO:0002283 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 0.1 GO:0021508 floor plate formation(GO:0021508)
0.0 0.1 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.0 0.1 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.0 0.3 GO:0000052 citrulline metabolic process(GO:0000052)
0.0 0.1 GO:0008215 spermine metabolic process(GO:0008215)
0.0 0.1 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.1 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.1 GO:0002689 negative regulation of leukocyte chemotaxis(GO:0002689)
0.0 0.1 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.3 GO:0061647 histone H3-K9 methylation(GO:0051567) histone H3-K9 modification(GO:0061647)
0.0 0.1 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0021825 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0 0.1 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 0.1 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.0 0.1 GO:0001553 luteinization(GO:0001553)
0.0 0.1 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.0 GO:0002328 pro-B cell differentiation(GO:0002328)
0.0 0.0 GO:0071698 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 0.2 GO:0031290 retinal ganglion cell axon guidance(GO:0031290)
0.0 0.0 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.0 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0 0.1 GO:0090009 primitive streak formation(GO:0090009)
0.0 0.1 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0 0.0 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.0 GO:0002887 negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.0 0.1 GO:0060644 mammary gland epithelial cell differentiation(GO:0060644)
0.0 0.0 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.0 0.0 GO:0032506 cytokinetic process(GO:0032506)
0.0 0.0 GO:0006106 fumarate metabolic process(GO:0006106)
0.0 0.1 GO:0019043 establishment of viral latency(GO:0019043) establishment of integrated proviral latency(GO:0075713)
0.0 0.2 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.0 GO:0001821 histamine secretion(GO:0001821)
0.0 0.4 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.0 0.0 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.0 0.1 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.1 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.0 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.0 0.2 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.0 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.1 GO:0003321 positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321)
0.0 0.0 GO:1903519 apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0 0.0 GO:0006565 L-serine catabolic process(GO:0006565)
0.0 0.0 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.0 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.0 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.0 GO:0046502 uroporphyrinogen III metabolic process(GO:0046502)
0.0 0.1 GO:0031641 regulation of myelination(GO:0031641)
0.0 0.1 GO:0006895 Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0 0.3 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0044462 external encapsulating structure part(GO:0044462)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.1 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0043259 laminin-10 complex(GO:0043259)
0.0 0.2 GO:0042581 specific granule(GO:0042581)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.1 GO:0031082 BLOC complex(GO:0031082) BLOC-1 complex(GO:0031083)
0.0 0.1 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.1 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.1 GO:0034518 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.0 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0 0.3 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.1 GO:0071565 nBAF complex(GO:0071565)
0.0 0.0 GO:0005606 laminin-1 complex(GO:0005606)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.1 0.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.2 GO:0030955 potassium ion binding(GO:0030955)
0.0 0.3 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.1 GO:0031544 procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0 0.3 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0005113 patched binding(GO:0005113)
0.0 0.1 GO:0097493 extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0 0.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.0 0.1 GO:0019959 C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.1 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.0 0.2 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.1 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.2 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.1 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0 0.0 GO:0070215 obsolete MDM2 binding(GO:0070215)
0.0 0.0 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.0 GO:0035198 miRNA binding(GO:0035198)
0.0 0.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.0 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.0 GO:0051425 PTB domain binding(GO:0051425)
0.0 0.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.0 GO:0045545 syndecan binding(GO:0045545)
0.0 0.0 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.0 GO:0016623 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0 0.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.0 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0 0.0 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.1 GO:0030553 cGMP binding(GO:0030553)
0.0 0.1 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0 0.0 GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID MYC PATHWAY C-MYC pathway
0.0 0.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.1 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME SIGNALING BY NOTCH3 Genes involved in Signaling by NOTCH3
0.0 0.2 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.3 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.0 REACTOME SIGNALING BY WNT Genes involved in Signaling by Wnt
0.0 0.4 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.1 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle