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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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Results for EMX1

Z-value: 0.77

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Transcription factors associated with EMX1

Gene Symbol	Gene ID	Gene Info
EMX1 Ensembl NCBI GeneCards UniProt	ENSG00000135638.9	empty spiracles homeobox 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr2_73207135_73207286	EMX1	56093	0.121757	-0.39	3.0e-01	Click!
chr2_73147833_73147984	EMX1	2598	0.320936	0.33	3.9e-01	Click!
chr2_73151228_73151379	EMX1	186	0.958240	-0.31	4.2e-01	Click!
chr2_73145753_73145999	EMX1	566	0.798884	0.25	5.2e-01	Click!
chr2_73145316_73145733	EMX1	214	0.949437	0.19	6.2e-01	Click!

Activity of the EMX1 motif across conditions

Conditions sorted by the z-value of the EMX1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr21_17909068_17909746	0.65	ENSG00000207638	.	2002	0.33
chr11_65324098_65324348	0.48	LTBP3	latent transforming growth factor beta binding protein 3	1013	0.31
chr13_38172411_38172686	0.47	POSTN	periostin, osteoblast specific factor	315	0.95
chrX_25020829_25021251	0.46	ARX	aristaless related homeobox	13025	0.26
chr3_98619475_98619750	0.41	DCBLD2	discoidin, CUB and LCCL domain containing 2	403	0.8
chr10_123458202_123458353	0.35	RP11-78A18.2		37541	0.2
chr15_96878465_96878729	0.34	ENSG00000222651	.	2107	0.24
chr15_96817385_96817602	0.33	NR2F2-AS1	NR2F2 antisense RNA 1	1732	0.37
chr18_53089837_53090372	0.33	TCF4	transcription factor 4	361	0.89
chr15_71054590_71054766	0.31	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	1091	0.55
chr17_37774592_37774840	0.31	PPP1R1B	protein phosphatase 1, regulatory (inhibitor) subunit 1B	8277	0.12
chr20_59830411_59830643	0.31	CDH4	cadherin 4, type 1, R-cadherin (retinal)	3045	0.42
chr13_34071233_34071384	0.30	STARD13	StAR-related lipid transfer (START) domain containing 13	146541	0.04
chr5_2750019_2750705	0.29	IRX2	iroquois homeobox 2	1407	0.43
chr10_63809082_63810748	0.29	ARID5B	AT rich interactive domain 5B (MRF1-like)	945	0.69
chr3_25471806_25472309	0.29	RARB	retinoic acid receptor, beta	2255	0.41
chr6_3750219_3750380	0.28	RP11-420L9.5		1046	0.5
chr4_109532705_109532935	0.28	RPL34	ribosomal protein L34	8902	0.2
chr21_17442999_17443232	0.28	ENSG00000252273	.	35286	0.24
chr3_112356169_112356393	0.28	CCDC80	coiled-coil domain containing 80	663	0.77
chr11_42259823_42259974	0.28	LRRC4C	leucine rich repeat containing 4C	778575	0.0
chr13_107160462_107160937	0.28	EFNB2	ephrin-B2	26763	0.24
chr4_186696107_186696537	0.27	SORBS2	sorbin and SH3 domain containing 2	108	0.98
chr11_131780111_131780399	0.27	NTM	neurotrimin	642	0.77
chr8_87188438_87188625	0.27	CTD-3118D11.3		4116	0.24
chr7_32109713_32110083	0.26	PDE1C	phosphodiesterase 1C, calmodulin-dependent 70kDa	563	0.87
chr4_95917210_95917447	0.26	BMPR1B	bone morphogenetic protein receptor, type IB	55	0.99
chr4_169553357_169553551	0.26	PALLD	palladin, cytoskeletal associated protein	686	0.73
chr13_109808054_109808728	0.25	MYO16-AS1	MYO16 antisense RNA 1	45440	0.18
chr6_116833589_116833880	0.25	TRAPPC3L	trafficking protein particle complex 3-like	228	0.83
chr10_33622034_33622426	0.25	NRP1	neuropilin 1	1080	0.63
chr17_831046_831241	0.25	RP11-676J12.7	Uncharacterized protein	18271	0.15
chr6_136990410_136990561	0.25	MAP3K5	mitogen-activated protein kinase kinase kinase 5	12886	0.19
chr2_54668695_54668846	0.25	SPTBN1	spectrin, beta, non-erythrocytic 1	14652	0.24
chr5_134370433_134370584	0.25	PITX1	paired-like homeodomain 1	5	0.97
chr11_86514261_86514754	0.24	PRSS23	protease, serine, 23	2922	0.38
chr7_77038696_77038897	0.24	GSAP	gamma-secretase activating protein	6388	0.24
chr9_21555895_21556299	0.24	MIR31HG	MIR31 host gene (non-protein coding)	3571	0.22
chr18_67910518_67910950	0.24	RTTN	rotatin	37553	0.17
chr10_33425652_33425891	0.24	ENSG00000263576	.	38207	0.16
chr2_157657104_157657488	0.24	ENSG00000263848	.	214473	0.02
chr13_76042243_76042399	0.23	TBC1D4	TBC1 domain family, member 4	13929	0.23
chr8_77592906_77593199	0.23	ZFHX4	zinc finger homeobox 4	402	0.86
chr11_126989829_126989980	0.23	KIRREL3-AS3	KIRREL3 antisense RNA 3	117099	0.06
chr1_16483683_16483834	0.23	EPHA2	EPH receptor A2	1176	0.29
chr11_6948113_6948733	0.23	ZNF215	zinc finger protein 215	670	0.62
chr3_159483781_159484285	0.23	IQCJ-SCHIP1	IQCJ-SCHIP1 readthrough	1141	0.44
chr17_66031093_66031463	0.23	KPNA2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	357	0.87
chr10_17707589_17707769	0.23	ENSG00000251959	.	13508	0.15
chr4_55093377_55093528	0.23	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	1812	0.46
chr17_60954301_60954474	0.23	ENSG00000207552	.	67189	0.11
chr3_13080776_13080942	0.23	IQSEC1	IQ motif and Sec7 domain 1	33758	0.22
chr8_27131821_27132033	0.23	STMN4	stathmin-like 4	15990	0.18
chr9_22008020_22008450	0.22	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	717	0.61
chr15_86037970_86038121	0.22	AKAP13	A kinase (PRKA) anchor protein 13	49226	0.13
chr10_29010683_29010909	0.22	ENSG00000201001	.	38936	0.14
chr6_117804579_117805184	0.22	DCBLD1	discoidin, CUB and LCCL domain containing 1	1056	0.49
chrX_86773476_86773748	0.22	KLHL4	kelch-like family member 4	795	0.74
chr6_108685387_108685624	0.22	ENSG00000200799	.	27772	0.18
chr2_238638558_238638814	0.22	LRRFIP1	leucine rich repeat (in FLII) interacting protein 1	37704	0.16
chr3_150131821_150132388	0.22	TSC22D2	TSC22 domain family, member 2	3308	0.35
chr3_79067433_79067887	0.22	ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)	34	0.99
chr15_67803077_67803228	0.22	C15orf61	chromosome 15 open reading frame 61	10254	0.21
chr1_197730742_197731002	0.22	RP11-448G4.4		4423	0.25
chr13_110957949_110958238	0.21	COL4A2	collagen, type IV, alpha 2	66	0.97
chr15_69367071_69367289	0.21	RP11-809H16.4		31275	0.17
chr4_160426427_160426682	0.21	ENSG00000251979	.	1626	0.54
chr10_30347491_30347726	0.21	KIAA1462	KIAA1462	845	0.76
chr9_135644688_135645326	0.21	RP11-295G24.5		592	0.77
chr1_159111648_159111897	0.21	AIM2	absent in melanoma 2	1474	0.37
chr1_88150357_88150552	0.21	ENSG00000199318	.	231398	0.02
chr9_75767359_75768171	0.21	ANXA1	annexin A1	947	0.7
chr13_33161756_33162354	0.21	PDS5B	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	1491	0.5
chr3_156893095_156894129	0.21	ENSG00000243176	.	476	0.72
chr9_43685829_43685980	0.21	CNTNAP3B	contactin associated protein-like 3B	994	0.67
chr9_41432727_41433091	0.21	SPATA31A5	SPATA31 subfamily A, member 5	67770	0.13
chr14_103522247_103522550	0.21	CDC42BPB	CDC42 binding protein kinase beta (DMPK-like)	1401	0.41
chr1_233723927_233724223	0.20	KCNK1	potassium channel, subfamily K, member 1	25675	0.21
chr3_16024121_16024347	0.20	ENSG00000207815	.	108956	0.06
chr15_96868192_96868343	0.20	NR2F2	nuclear receptor subfamily 2, group F, member 2	900	0.49
chr9_136889856_136890052	0.20	LINC00094	long intergenic non-protein coding RNA 94	607	0.71
chr15_71006306_71006466	0.20	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	10772	0.26
chr8_77589944_77590318	0.20	ZFHX4	zinc finger homeobox 4	3323	0.29
chr12_56917781_56918152	0.20	RBMS2	RNA binding motif, single stranded interacting protein 2	2183	0.23
chr11_20179312_20179463	0.20	DBX1	developing brain homeobox 1	2483	0.35
chr4_119755136_119755442	0.20	SEC24D	SEC24 family member D	2004	0.43
chr17_35289223_35289419	0.20	RP11-445F12.1		4600	0.15
chr13_106899243_106899412	0.20	ENSG00000222682	.	91488	0.09
chr4_183475412_183475644	0.20	ENSG00000252343	.	5716	0.29
chrX_6697105_6697256	0.20	VCX3A	variable charge, X-linked 3A	244021	0.02
chr9_39287322_39287607	0.20	CNTNAP3	contactin associated protein-like 3	628	0.81
chr3_56501298_56501701	0.20	ERC2	ELKS/RAB6-interacting/CAST family member 2	892	0.73
chr3_105657205_105657471	0.20	CBLB	Cbl proto-oncogene B, E3 ubiquitin protein ligase	68942	0.15
chr12_116008040_116008436	0.20	ENSG00000240205	.	147292	0.05
chr1_78472118_78472672	0.20	DNAJB4	DnaJ (Hsp40) homolog, subfamily B, member 4	1857	0.26
chr9_3794141_3794308	0.20	RP11-252M18.3		81360	0.1
chr4_66533756_66533907	0.20	EPHA5	EPH receptor A5	1822	0.52
chr7_116312981_116313724	0.19	MET	met proto-oncogene	893	0.68
chr5_124082726_124083211	0.19	ZNF608	zinc finger protein 608	648	0.62
chr10_69867817_69868100	0.19	MYPN	myopalladin	1036	0.55
chr8_48648492_48649280	0.19	CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	2762	0.26
chr2_43746685_43747132	0.19	THADA	thyroid adenoma associated	50746	0.15
chr4_66536403_66536611	0.19	EPHA5	EPH receptor A5	294	0.95
chr3_69129681_69129838	0.19	UBA3	ubiquitin-like modifier activating enzyme 3	200	0.92
chr5_172753672_172753903	0.19	STC2	stanniocalcin 2	13	0.98
chr2_27861313_27861464	0.19	ENSG00000206731	.	3648	0.13
chr11_86406998_86407150	0.19	ME3	malic enzyme 3, NADP(+)-dependent, mitochondrial	23396	0.25
chr18_67822225_67822376	0.19	RTTN	rotatin	50662	0.17
chr1_78471558_78472034	0.19	DNAJB4	DnaJ (Hsp40) homolog, subfamily B, member 4	1258	0.34
chr3_171592483_171592715	0.19	TMEM212-IT1	TMEM212 intronic transcript 1 (non-protein coding)	19627	0.19
chr3_177954621_177954974	0.19	KCNMB2	potassium large conductance calcium-activated channel, subfamily M, beta member 2	35923	0.23
chr5_118653769_118653920	0.19	ENSG00000243333	.	11518	0.19
chr9_21973547_21973827	0.19	CDKN2A	cyclin-dependent kinase inhibitor 2A	1170	0.41
chr7_28726429_28726958	0.19	CREB5	cAMP responsive element binding protein 5	1095	0.68
chr2_202987834_202988283	0.19	AC079354.3		6277	0.17
chr16_50531355_50531506	0.19	ENSG00000252077	.	711	0.7
chr15_88020923_88021173	0.19	ENSG00000207150	.	3528	0.4
chr1_225610206_225610357	0.19	LBR	lamin B receptor	5318	0.2
chr18_30310087_30311054	0.19	AC012123.1	Uncharacterized protein	39188	0.17
chr16_86599945_86600151	0.19	FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	809	0.48
chr11_104838069_104839428	0.19	CASP4	caspase 4, apoptosis-related cysteine peptidase	1345	0.45
chr12_76816173_76817087	0.18	OSBPL8	oxysterol binding protein-like 8	416	0.9
chr12_14369272_14369482	0.18	ENSG00000266749	.	3349	0.3
chr12_10821249_10821400	0.18	STYK1	serine/threonine/tyrosine kinase 1	4933	0.2
chr7_98029134_98029377	0.18	BAIAP2L1	BAI1-associated protein 2-like 1	1125	0.59
chr21_35898258_35899173	0.18	RCAN1	regulator of calcineurin 1	407	0.86
chr17_13424489_13424747	0.18	ENSG00000266115	.	20973	0.19
chr12_50615145_50616830	0.18	LIMA1	LIM domain and actin binding 1	144	0.93
chr6_151188569_151188720	0.18	MTHFD1L	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	951	0.67
chr1_109740352_109740715	0.18	ENSG00000238310	.	9937	0.15
chr5_87968314_87968590	0.18	CTC-467M3.1		3584	0.24
chr12_46757806_46758524	0.18	SLC38A2	solute carrier family 38, member 2	925	0.64
chr10_116474996_116475239	0.18	ABLIM1	actin binding LIM protein 1	30703	0.21
chr4_186853985_186854481	0.18	ENSG00000239034	.	13004	0.21
chr12_76271082_76271233	0.18	ENSG00000243420	.	80753	0.1
chr5_142600508_142600686	0.18	ARHGAP26	Rho GTPase activating protein 26	13832	0.24
chrX_117490564_117490715	0.18	WDR44	WD repeat domain 44	10533	0.21
chr17_10601145_10601947	0.18	ADPRM	ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent	635	0.41
chr5_142556532_142556683	0.18	ARHGAP26-IT1	ARHGAP26 intronic transcript 1 (non-protein coding)	15458	0.24
chr15_60388257_60388408	0.18	FOXB1	forkhead box B1	91911	0.09
chr1_112283056_112283209	0.18	FAM212B-AS1	FAM212B antisense RNA 1	657	0.55
chr7_142981719_142981870	0.18	TMEM139	transmembrane protein 139	249	0.82
chr13_24275550_24275701	0.18	AL139080.1	Uncharacterized protein	46618	0.16
chr6_111136518_111136697	0.18	CDK19	cyclin-dependent kinase 19	88	0.97
chr12_72724242_72724393	0.18	ENSG00000236333	.	55630	0.15
chr8_77599205_77599356	0.18	ZFHX4	zinc finger homeobox 4	3264	0.28
chr10_6763782_6764322	0.18	PRKCQ	protein kinase C, theta	141789	0.05
chr4_105315936_105316087	0.18	ENSG00000272082	.	96022	0.08
chr5_77822199_77822489	0.18	LHFPL2	lipoma HMGIC fusion partner-like 2	22630	0.27
chr17_64476407_64476558	0.18	RP11-4F22.2		63510	0.12
chr15_31631556_31631837	0.17	KLF13	Kruppel-like factor 13	440	0.9
chr8_12986347_12986498	0.17	DLC1	deleted in liver cancer 1	4561	0.27
chr14_25580559_25580710	0.17	STXBP6	syntaxin binding protein 6 (amisyn)	61131	0.16
chr6_116834038_116834189	0.17	TRAPPC3L	trafficking protein particle complex 3-like	607	0.55
chr5_102897969_102898137	0.17	NUDT12	nudix (nucleoside diphosphate linked moiety X)-type motif 12	437	0.91
chr6_165341513_165341675	0.17	C6orf118	chromosome 6 open reading frame 118	380748	0.01
chr17_66700653_66700804	0.17	ENSG00000263690	.	61972	0.13
chr3_81474618_81474769	0.17	ENSG00000222389	.	83934	0.11
chr1_244175859_244176064	0.17	ZBTB18	zinc finger and BTB domain containing 18	38624	0.17
chr2_213962198_213962349	0.17	IKZF2	IKAROS family zinc finger 2 (Helios)	51080	0.16
chr18_3305605_3305756	0.17	MYL12B	myosin, light chain 12B, regulatory	42726	0.12
chr3_156469026_156469297	0.17	TIPARP	TCDD-inducible poly(ADP-ribose) polymerase	70206	0.1
chr1_68152763_68153190	0.17	GADD45A	growth arrest and DNA-damage-inducible, alpha	2092	0.36
chr10_105609571_105609851	0.17	SH3PXD2A	SH3 and PX domains 2A	5453	0.22
chr12_59509571_59509775	0.17	RP11-150C16.1		195253	0.03
chr11_37129867_37130018	0.17	RAG2	recombination activating gene 2	510156	0.0
chr1_52363576_52363890	0.17	ENSG00000265769	.	2910	0.2
chr19_46088302_46088477	0.17	OPA3	optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)	289	0.84
chr12_80794329_80794553	0.17	PTPRQ	protein tyrosine phosphatase, receptor type, Q	5333	0.26
chr4_177191568_177191827	0.17	ASB5	ankyrin repeat and SOCS box containing 5	1324	0.49
chr4_37979283_37980288	0.17	TBC1D1	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	854	0.69
chr17_30954528_30954679	0.17	RP11-220C2.1		154	0.96
chr4_14728626_14728777	0.17	ENSG00000202449	.	36367	0.24
chr11_93865075_93865400	0.17	PANX1	pannexin 1	3142	0.34
chr3_111820458_111820788	0.17	ENSG00000207940	.	11025	0.15
chr4_6887879_6888223	0.17	TBC1D14	TBC1 domain family, member 14	22918	0.18
chr17_12569246_12569498	0.17	MYOCD	myocardin	66	0.98
chr7_32099128_32099768	0.17	PDE1C	phosphodiesterase 1C, calmodulin-dependent 70kDa	11013	0.32
chr4_166361643_166362016	0.17	CPE	carboxypeptidase E	22451	0.23
chr8_107071271_107071422	0.17	ENSG00000251003	.	1325	0.61
chr8_38264174_38264701	0.17	RP11-350N15.6		1823	0.22
chrX_45626469_45627939	0.16	ENSG00000207725	.	20674	0.22
chr8_32440879_32441165	0.16	NRG1	neuregulin 1	22144	0.27
chr2_8135764_8135915	0.16	ENSG00000221255	.	418867	0.01
chr7_30202290_30202472	0.16	AC007036.5		5234	0.19
chr7_20371750_20371946	0.16	CTA-293F17.1		478	0.71
chr13_95752508_95752659	0.16	ENSG00000252335	.	81094	0.1
chr13_110439180_110439367	0.16	IRS2	insulin receptor substrate 2	358	0.92
chr7_134465735_134465936	0.16	CALD1	caldesmon 1	1406	0.57
chr10_116584415_116584656	0.16	FAM160B1	family with sequence similarity 160, member B1	3006	0.37
chr18_74781332_74781483	0.16	MBP	myelin basic protein	35810	0.21
chr3_153644904_153645055	0.16	ENSG00000238755	.	52996	0.15
chr1_28833432_28833903	0.16	SNHG3	small nucleolar RNA host gene 3 (non-protein coding)	211	0.82
chr9_135038389_135038692	0.16	NTNG2	netrin G2	1206	0.56
chr7_80513051_80513202	0.16	SEMA3C	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	35373	0.24
chr14_29859562_29859789	0.16	ENSG00000257522	.	11813	0.29
chr11_12699031_12699547	0.16	TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	2239	0.43
chr1_162603392_162603656	0.16	DDR2	discoidin domain receptor tyrosine kinase 2	1264	0.48
chr12_49661445_49661747	0.16	TUBA1C	tubulin, alpha 1c	2732	0.15
chr2_64244915_64245982	0.16	VPS54	vacuolar protein sorting 54 homolog (S. cerevisiae)	758	0.76

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of EMX1

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.1	0.3	GO:0022605	oogenesis stage(GO:0022605)
0.1	0.4	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.3	GO:0021823	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.1	0.2	GO:0030210	heparin biosynthetic process(GO:0030210)
0.1	0.2	GO:0070932	histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.1	0.3	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.1	0.2	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.1	0.3	GO:0043589	skin morphogenesis(GO:0043589)
0.1	0.4	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.1	0.2	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.1	0.2	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.1	0.1	GO:0072081	proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.1	0.2	GO:0072007	mesangial cell differentiation(GO:0072007) kidney interstitial fibroblast differentiation(GO:0072071) renal interstitial fibroblast development(GO:0072141) mesangial cell development(GO:0072143) pericyte cell differentiation(GO:1904238)
0.1	0.3	GO:0061001	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.1	0.2	GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0	0.1	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.3	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.1	GO:0003179	heart valve development(GO:0003170) heart valve morphogenesis(GO:0003179)
0.0	0.2	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.2	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.1	GO:0035583	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.2	GO:0043497	regulation of protein heterodimerization activity(GO:0043497)
0.0	0.1	GO:0045578	negative regulation of B cell differentiation(GO:0045578)
0.0	0.1	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0	0.1	GO:0032808	lacrimal gland development(GO:0032808)
0.0	0.1	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.0	0.2	GO:0042416	dopamine biosynthetic process(GO:0042416)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.3	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.2	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0097709	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0	0.2	GO:0021891	olfactory bulb interneuron development(GO:0021891)
0.0	0.2	GO:0048755	branching morphogenesis of a nerve(GO:0048755)
0.0	0.2	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.0	GO:0072268	pattern specification involved in metanephros development(GO:0072268)
0.0	0.1	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.0	0.1	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.2	GO:0090083	regulation of inclusion body assembly(GO:0090083)
0.0	0.0	GO:0060916	mesenchymal cell proliferation involved in lung development(GO:0060916)
0.0	0.3	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)
0.0	0.1	GO:1903332	regulation of protein folding(GO:1903332)
0.0	0.1	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.0	0.1	GO:0060057	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0	0.2	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0021898	commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0	0.1	GO:0070561	vitamin D receptor signaling pathway(GO:0070561)
0.0	0.2	GO:0045116	protein neddylation(GO:0045116)
0.0	0.1	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.3	GO:0048207	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0	0.0	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0	0.2	GO:0014912	negative regulation of smooth muscle cell migration(GO:0014912)
0.0	0.1	GO:0010799	regulation of peptidyl-threonine phosphorylation(GO:0010799)
0.0	0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.1	GO:0009174	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0	0.1	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.3	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.1	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.2	GO:0001553	luteinization(GO:0001553)
0.0	0.1	GO:0009296	obsolete flagellum assembly(GO:0009296)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.4	GO:0035329	hippo signaling(GO:0035329)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.1	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.1	GO:0060174	limb bud formation(GO:0060174)
0.0	0.1	GO:0008049	male courtship behavior(GO:0008049)
0.0	0.1	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.1	GO:1900078	positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0	0.1	GO:0048539	bone marrow development(GO:0048539)
0.0	0.3	GO:0000085	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.1	GO:0008354	germ cell migration(GO:0008354)
0.0	0.0	GO:0061299	retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0	0.0	GO:0060594	mammary gland specification(GO:0060594)
0.0	0.1	GO:0050689	negative regulation of defense response to virus by host(GO:0050689)
0.0	0.1	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0	0.1	GO:0042984	amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.0	GO:0071072	negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0	0.1	GO:0002669	lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.2	GO:0046426	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.1	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.1	GO:0051409	response to nitrosative stress(GO:0051409)
0.0	0.1	GO:0097531	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0	0.2	GO:0006553	lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0	0.1	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0	0.2	GO:0036294	cellular response to decreased oxygen levels(GO:0036294) cellular response to oxygen levels(GO:0071453) cellular response to hypoxia(GO:0071456)
0.0	0.1	GO:0031641	regulation of myelination(GO:0031641)
0.0	0.0	GO:0046882	negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0	0.2	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.1	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.1	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.1	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.4	GO:0008038	neuron recognition(GO:0008038)
0.0	0.1	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.0	0.1	GO:0051573	negative regulation of histone H3-K9 methylation(GO:0051573)
0.0	0.1	GO:0032057	negative regulation of translational initiation in response to stress(GO:0032057)
0.0	0.0	GO:0060900	embryonic camera-type eye formation(GO:0060900)
0.0	0.1	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.0	0.0	GO:0055089	fatty acid homeostasis(GO:0055089)
0.0	0.2	GO:0045176	apical protein localization(GO:0045176)
0.0	0.1	GO:1904358	positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0	0.1	GO:0002541	activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0	0.1	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.1	GO:0060206	estrous cycle phase(GO:0060206)
0.0	0.0	GO:0032060	bleb assembly(GO:0032060)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0000492	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.1	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.0	GO:0009261	ribonucleotide catabolic process(GO:0009261)
0.0	0.1	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.1	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.0	GO:0060766	negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0	0.1	GO:0048745	smooth muscle tissue development(GO:0048745)
0.0	0.2	GO:0006047	UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.0	0.1	GO:0001514	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0	0.1	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.0	GO:0045540	regulation of cholesterol biosynthetic process(GO:0045540)
0.0	0.1	GO:0031529	ruffle organization(GO:0031529)
0.0	0.2	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0	0.1	GO:0045002	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0	0.1	GO:0043457	regulation of cellular respiration(GO:0043457)
0.0	0.1	GO:0051014	actin filament severing(GO:0051014)
0.0	0.1	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.0	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0	0.1	GO:0006983	ER overload response(GO:0006983)
0.0	0.0	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.1	GO:0060287	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.1	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.1	GO:0032543	mitochondrial translation(GO:0032543)
0.0	0.1	GO:0043461	proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0	0.1	GO:0051103	DNA ligation involved in DNA repair(GO:0051103)
0.0	0.1	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.0	0.0	GO:0060449	bud elongation involved in lung branching(GO:0060449)
0.0	0.3	GO:0006084	acetyl-CoA metabolic process(GO:0006084)
0.0	0.0	GO:0047484	regulation of response to osmotic stress(GO:0047484)
0.0	0.1	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.0	GO:0030185	nitric oxide transport(GO:0030185)
0.0	0.0	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.0	GO:0060751	branch elongation involved in mammary gland duct branching(GO:0060751)
0.0	0.1	GO:0045542	positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0	0.0	GO:0006434	seryl-tRNA aminoacylation(GO:0006434)
0.0	0.0	GO:0032071	regulation of endodeoxyribonuclease activity(GO:0032071)
0.0	0.0	GO:0051708	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.0	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.0	GO:0060487	lung epithelial cell differentiation(GO:0060487)
0.0	0.0	GO:0006925	inflammatory cell apoptotic process(GO:0006925)
0.0	0.0	GO:0051541	elastin metabolic process(GO:0051541)
0.0	0.1	GO:0015781	pyrimidine nucleotide-sugar transport(GO:0015781)
0.0	0.0	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.1	GO:0021591	ventricular system development(GO:0021591)
0.0	0.1	GO:0001945	lymph vessel development(GO:0001945)
0.0	0.1	GO:0051927	obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051927)
0.0	0.1	GO:0010107	potassium ion import(GO:0010107)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.1	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.0	GO:0050703	interleukin-1 alpha secretion(GO:0050703)
0.0	0.1	GO:0060124	positive regulation of growth hormone secretion(GO:0060124)
0.0	0.1	GO:0010870	positive regulation of receptor biosynthetic process(GO:0010870)
0.0	0.0	GO:0046185	aldehyde catabolic process(GO:0046185)
0.0	0.1	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.0	GO:0010216	maintenance of DNA methylation(GO:0010216)
0.0	0.0	GO:0045992	negative regulation of embryonic development(GO:0045992)
0.0	0.1	GO:0009120	deoxyribonucleoside metabolic process(GO:0009120)
0.0	0.0	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.1	GO:1901863	positive regulation of striated muscle tissue development(GO:0045844) positive regulation of muscle organ development(GO:0048636) positive regulation of muscle tissue development(GO:1901863)
0.0	0.1	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.1	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.0	0.1	GO:0042769	DNA damage response, detection of DNA damage(GO:0042769)
0.0	0.0	GO:0033023	mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) ectopic germ cell programmed cell death(GO:0035234)
0.0	0.1	GO:0006658	phosphatidylserine metabolic process(GO:0006658)
0.0	0.1	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.0	0.2	GO:0048384	retinoic acid receptor signaling pathway(GO:0048384)
0.0	0.1	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.1	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.0	0.1	GO:0045747	positive regulation of Notch signaling pathway(GO:0045747)
0.0	0.1	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.0	GO:0035246	peptidyl-arginine methylation(GO:0018216) peptidyl-arginine N-methylation(GO:0035246)
0.0	0.0	GO:0001705	ectoderm formation(GO:0001705)
0.0	0.0	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0048844	artery morphogenesis(GO:0048844)
0.0	0.0	GO:0030187	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.1	GO:0016584	nucleosome positioning(GO:0016584)
0.0	0.3	GO:0006309	DNA catabolic process, endonucleolytic(GO:0000737) apoptotic DNA fragmentation(GO:0006309)
0.0	0.0	GO:0007144	female meiosis I(GO:0007144)
0.0	0.0	GO:0031282	regulation of guanylate cyclase activity(GO:0031282)
0.0	0.0	GO:1901984	negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0	0.0	GO:0051532	NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0	0.1	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.0	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.2	GO:0030968	endoplasmic reticulum unfolded protein response(GO:0030968) cellular response to unfolded protein(GO:0034620)
0.0	0.0	GO:0060081	membrane hyperpolarization(GO:0060081)
0.0	0.0	GO:0010915	regulation of very-low-density lipoprotein particle clearance(GO:0010915) negative regulation of very-low-density lipoprotein particle clearance(GO:0010916)
0.0	0.1	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.1	GO:0043392	negative regulation of DNA binding(GO:0043392)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.1	GO:0007064	mitotic sister chromatid cohesion(GO:0007064)
0.0	0.0	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.1	GO:0042797	5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0	0.1	GO:0006999	nuclear pore organization(GO:0006999)
0.0	0.0	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.0	GO:0006152	purine nucleoside catabolic process(GO:0006152) purine ribonucleoside catabolic process(GO:0046130)
0.0	0.0	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.0	GO:0009221	pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221)
0.0	0.0	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	0.1	GO:0071044	histone mRNA catabolic process(GO:0071044)
0.0	0.0	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.1	GO:0006379	mRNA cleavage(GO:0006379)
0.0	0.0	GO:0043267	negative regulation of potassium ion transport(GO:0043267)
0.0	0.0	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.0	0.0	GO:0060009	Sertoli cell development(GO:0060009)
0.0	0.2	GO:0030520	intracellular estrogen receptor signaling pathway(GO:0030520)
0.0	0.0	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.0	GO:0030952	establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.0	0.0	GO:0002138	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0	0.0	GO:0051790	short-chain fatty acid biosynthetic process(GO:0051790)
0.0	0.8	GO:0006367	transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0	0.0	GO:0046476	glycosylceramide biosynthetic process(GO:0046476)
0.0	0.0	GO:0035519	protein K29-linked ubiquitination(GO:0035519)
0.0	0.1	GO:0098927	early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0	0.0	GO:0009186	deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.0	0.0	GO:0003254	regulation of membrane depolarization(GO:0003254) regulation of mitochondrial depolarization(GO:0051900)
0.0	0.3	GO:0051925	obsolete regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051925)
0.0	0.1	GO:0045773	positive regulation of axon extension(GO:0045773)
0.0	0.1	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.0	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.6	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:0000288)
0.0	0.1	GO:0042219	cellular modified amino acid catabolic process(GO:0042219)
0.0	0.0	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.0	GO:0044803	multi-organism membrane organization(GO:0044803)
0.0	0.1	GO:0071479	cellular response to ionizing radiation(GO:0071479)
0.0	0.1	GO:0016973	poly(A)+ mRNA export from nucleus(GO:0016973)
0.0	0.1	GO:0007076	mitotic chromosome condensation(GO:0007076)
0.0	0.2	GO:0006730	one-carbon metabolic process(GO:0006730)
0.0	0.0	GO:0060017	parathyroid gland development(GO:0060017)
0.0	0.0	GO:0032288	myelin assembly(GO:0032288)
0.0	0.0	GO:0045329	amino-acid betaine biosynthetic process(GO:0006578) carnitine biosynthetic process(GO:0045329)
0.0	0.1	GO:0047496	vesicle transport along microtubule(GO:0047496) vesicle cytoskeletal trafficking(GO:0099518)
0.0	0.0	GO:0006378	mRNA polyadenylation(GO:0006378)
0.0	0.0	GO:0034629	cellular protein complex localization(GO:0034629)
0.0	0.0	GO:0045040	outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.1	GO:0007494	midgut development(GO:0007494)
0.0	0.0	GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0	0.1	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0	0.0	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	0.2	GO:0007052	mitotic spindle organization(GO:0007052)
0.0	0.0	GO:0007132	meiotic metaphase I(GO:0007132)
0.0	0.1	GO:0051881	regulation of mitochondrial membrane potential(GO:0051881)
0.0	0.4	GO:0030522	intracellular receptor signaling pathway(GO:0030522)
0.0	0.0	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.0	0.0	GO:0072385	minus-end-directed organelle transport along microtubule(GO:0072385)
0.0	0.1	GO:0008347	glial cell migration(GO:0008347)
0.0	0.0	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978)
0.0	0.0	GO:0032278	positive regulation of gonadotropin secretion(GO:0032278) positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0	0.0	GO:0010738	regulation of protein kinase A signaling(GO:0010738)
0.0	0.1	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0	0.1	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.0	0.3	GO:0000725	double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725)
0.0	0.0	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0043259	laminin-10 complex(GO:0043259)
0.3	GO:0098645	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.2	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.2	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.3	GO:0005916	fascia adherens(GO:0005916)
0.2	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.2	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.3	GO:0030127	COPII vesicle coat(GO:0030127)
0.3	GO:0005614	interstitial matrix(GO:0005614)
0.1	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1	GO:0017059	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.1	GO:0070852	cell body fiber(GO:0070852)
0.1	GO:0042587	glycogen granule(GO:0042587)
0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1	GO:0031932	TORC2 complex(GO:0031932)
0.1	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.0	GO:0032449	CBM complex(GO:0032449)
0.0	GO:0044291	intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.1	GO:0071256	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.1	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.3	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.1	GO:0072487	MSL complex(GO:0072487)
0.2	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.2	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.1	GO:0070761	pre-snoRNP complex(GO:0070761)
0.1	GO:0005851	eukaryotic translation initiation factor 2B complex(GO:0005851)
0.1	GO:0031430	M band(GO:0031430)
0.1	GO:0031512	motile primary cilium(GO:0031512)
0.4	GO:0005689	U12-type spliceosomal complex(GO:0005689)
0.1	GO:0071778	obsolete WINAC complex(GO:0071778)
0.1	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.2	GO:0005849	mRNA cleavage factor complex(GO:0005849)
0.1	GO:0042598	obsolete vesicular fraction(GO:0042598)
0.2	GO:0005811	lipid particle(GO:0005811)
0.0	GO:0031262	Ndc80 complex(GO:0031262)
0.1	GO:0017119	Golgi transport complex(GO:0017119)
0.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.1	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.4	GO:0030018	Z disc(GO:0030018)
0.3	GO:0009925	basal plasma membrane(GO:0009925)
0.9	GO:0030426	growth cone(GO:0030426)
0.1	GO:0005719	nuclear euchromatin(GO:0005719)
0.1	GO:0043034	costamere(GO:0043034)
0.1	GO:0035327	transcriptionally active chromatin(GO:0035327)
0.6	GO:0000118	histone deacetylase complex(GO:0000118)
0.2	GO:0005763	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.3	GO:0034704	calcium channel complex(GO:0034704)
0.1	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.8	GO:0030016	myofibril(GO:0030016)
0.3	GO:0017053	transcriptional repressor complex(GO:0017053)
0.1	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)
0.1	GO:0000796	condensin complex(GO:0000796)
0.1	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.2	GO:0030057	desmosome(GO:0030057)
0.3	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.4	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.0	GO:0071986	Ragulator complex(GO:0071986)
0.1	GO:0031010	ISWI-type complex(GO:0031010)
0.1	GO:0005868	cytoplasmic dynein complex(GO:0005868)
0.1	GO:0031941	filamentous actin(GO:0031941)
0.1	GO:0005869	dynactin complex(GO:0005869)
0.4	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	GO:0044217	host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.1	GO:0045275	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.4	GO:0001098	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.2	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.1	0.4	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.1	0.4	GO:0017154	semaphorin receptor activity(GO:0017154)
0.1	0.2	GO:0042577	lipid phosphatase activity(GO:0042577)
0.1	0.2	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1	0.5	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.1	GO:0008502	melatonin receptor activity(GO:0008502)
0.0	0.1	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.2	GO:0016886	ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0	0.2	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.2	GO:0055103	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.2	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.1	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.2	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.2	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.2	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.1	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.1	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.2	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.2	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.3	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.1	GO:0048185	activin binding(GO:0048185)
0.0	0.1	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.4	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.1	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.2	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.1	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.6	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.1	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.0	0.0	GO:0043175	RNA polymerase core enzyme binding(GO:0043175)
0.0	0.1	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.0	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0	0.1	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.1	GO:0032558	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.1	GO:0004142	diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0	0.2	GO:0004551	nucleotide diphosphatase activity(GO:0004551)
0.0	0.1	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.1	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.2	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	0.0	GO:0050682	AF-2 domain binding(GO:0050682)
0.0	0.2	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.2	GO:0005003	ephrin receptor activity(GO:0005003)
0.0	0.0	GO:0045159	myosin II binding(GO:0045159)
0.0	0.1	GO:0034711	inhibin binding(GO:0034711)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.0	GO:0016362	activin receptor activity, type II(GO:0016362)
0.0	0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.2	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.2	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.1	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.1	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.2	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.0	GO:0045545	syndecan binding(GO:0045545)
0.0	0.2	GO:0031490	chromatin DNA binding(GO:0031490)
0.0	0.0	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.3	GO:0050699	WW domain binding(GO:0050699)
0.0	0.1	GO:0030515	snoRNA binding(GO:0030515)
0.0	0.0	GO:0004828	serine-tRNA ligase activity(GO:0004828)
0.0	0.2	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.2	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0	0.0	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.2	GO:0005024	transforming growth factor beta-activated receptor activity(GO:0005024)
0.0	0.0	GO:0004461	lactose synthase activity(GO:0004461)
0.0	0.0	GO:0004517	nitric-oxide synthase activity(GO:0004517)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.1	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
0.0	0.1	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.0	GO:0031705	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.1	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
0.0	0.1	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.0	0.1	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.2	GO:0031078	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0	0.1	GO:0070628	proteasome binding(GO:0070628)
0.0	0.1	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.0	GO:0008821	crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0	0.0	GO:0034618	arginine binding(GO:0034618)
0.0	0.4	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0	0.0	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.0	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.0	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.0	GO:0017108	5'-flap endonuclease activity(GO:0017108)
0.0	0.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0035173	histone kinase activity(GO:0035173)
0.0	0.1	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.3	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.0	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.1	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.0	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.0	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.2	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.1	GO:0008312	7S RNA binding(GO:0008312)
0.0	0.1	GO:0019966	interleukin-1 binding(GO:0019966)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.0	GO:0001159	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.0	GO:0031177	phosphopantetheine binding(GO:0031177)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.0	GO:0055077	gap junction hemi-channel activity(GO:0055077)
0.0	0.1	GO:0061659	ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0	0.0	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.0	GO:0004525	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0	0.0	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.0	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.1	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.0	GO:0004739	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.2	GO:0008484	sulfuric ester hydrolase activity(GO:0008484)
0.0	0.0	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.0	0.0	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.0	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0	0.1	GO:0004437	obsolete inositol or phosphatidylinositol phosphatase activity(GO:0004437)
0.0	0.0	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	0.0	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.1	GO:0016273	arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0	0.0	GO:0032356	single guanine insertion binding(GO:0032142) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357)
0.0	0.1	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
0.0	0.0	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.0	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.0	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.0	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.0	0.5	GO:0008301	DNA binding, bending(GO:0008301)
0.0	0.1	GO:0008409	5'-3' exonuclease activity(GO:0008409)
0.0	0.1	GO:0008252	nucleotidase activity(GO:0008252)
0.0	0.1	GO:0045502	dynein binding(GO:0045502)
0.0	0.0	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.0	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.0	GO:0004576	oligosaccharyl transferase activity(GO:0004576)
0.0	0.1	GO:0005048	signal sequence binding(GO:0005048)
0.0	0.0	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.1	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.0	0.2	GO:0008320	protein transmembrane transporter activity(GO:0008320)
0.0	0.1	GO:0043498	obsolete cell surface binding(GO:0043498)
0.0	0.1	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.2	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
0.0	0.3	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.0	0.0	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.0	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	0.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	0.2	PID IGF1 PATHWAY	IGF1 pathway
0.0	0.1	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.0	1.0	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	0.1	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	0.9	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	0.0	PID ALK1 PATHWAY	ALK1 signaling events
0.0	0.2	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.7	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.0	0.0	PID TRAIL PATHWAY	TRAIL signaling pathway
0.0	0.6	PID BMP PATHWAY	BMP receptor signaling
0.0	0.3	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	0.5	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.0	0.0	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.0	0.2	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	0.0	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0	0.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	0.1	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.0	0.1	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	0.2	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.0	0.3	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	0.4	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	0.1	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	0.2	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.5	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.0	0.3	PID FOXO PATHWAY	FoxO family signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.0	REACTOME GPCR LIGAND BINDING	Genes involved in GPCR ligand binding
0.0	0.0	REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0	0.1	REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0	0.3	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.0	REACTOME IL 2 SIGNALING	Genes involved in Interleukin-2 signaling
0.0	0.7	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.3	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.5	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.3	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.1	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0	0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	0.3	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.2	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	0.2	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.2	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.0	0.1	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.0	0.2	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.0	0.3	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.2	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	0.0	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0	0.5	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	0.2	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0	0.2	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	0.2	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	0.2	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	0.2	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.0	0.1	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.3	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.1	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.0	0.2	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.0	0.7	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.2	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.3	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	0.0	REACTOME SIGNALING BY ERBB2	Genes involved in Signaling by ERBB2
0.0	0.0	REACTOME RNA POL I TRANSCRIPTION INITIATION	Genes involved in RNA Polymerase I Transcription Initiation
0.0	0.5	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.0	0.1	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.1	REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX	Genes involved in TRAF6 mediated induction of TAK1 complex
0.0	0.3	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.0	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	0.0	REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0	0.2	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.2	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.0	0.0	REACTOME SIGNALLING TO P38 VIA RIT AND RIN	Genes involved in Signalling to p38 via RIT and RIN
0.0	0.1	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.0	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.1	REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH	Genes involved in NCAM signaling for neurite out-growth
0.0	0.0	REACTOME VIRAL MESSENGER RNA SYNTHESIS	Genes involved in Viral Messenger RNA Synthesis
0.0	0.1	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0	0.1	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4
0.0	0.2	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0	0.1	REACTOME RNA POL I TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase I Transcription Termination
0.0	0.0	REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0	0.1	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0	0.2	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0	0.3	REACTOME MRNA SPLICING MINOR PATHWAY	Genes involved in mRNA Splicing - Minor Pathway

Results for EMX1

Z-value: 0.77

Motif logo

Transcription factors associated with EMX1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the EMX1 motif across conditions

Conditions sorted by the z-value of the EMX1 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of EMX1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: