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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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Results for EMX2

Z-value: 1.89

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Transcription factors associated with EMX2

Gene Symbol	Gene ID	Gene Info
EMX2 Ensembl NCBI GeneCards UniProt	ENSG00000170370.10	empty spiracles homeobox 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr10_119302142_119302346	EMX2	265	0.637902	-0.43	2.4e-01	Click!
chr10_119303143_119303333	EMX2	729	0.610624	-0.10	8.0e-01	Click!
chr10_119301926_119302136	EMX2	76	0.660911	0.01	9.8e-01	Click!

Activity of the EMX2 motif across conditions

Conditions sorted by the z-value of the EMX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr9_123682878_123683088	0.86	TRAF1	TNF receptor-associated factor 1	6133	0.22
chr14_22974481_22974956	0.85	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	18547	0.09
chr4_84035334_84035716	0.81	PLAC8	placenta-specific 8	343	0.91
chr1_39681454_39681741	0.75	RP11-416A14.1		9413	0.17
chr20_21080465_21081932	0.74	ENSG00000199509	.	38517	0.18
chr12_47611625_47611801	0.72	PCED1B	PC-esterase domain containing 1B	1332	0.49
chr4_153431926_153432077	0.71	ENSG00000264678	.	21433	0.17
chr13_31309966_31310295	0.71	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	485	0.88
chr14_91882143_91882344	0.70	CCDC88C	coiled-coil domain containing 88C	1447	0.49
chr2_204573850_204574006	0.68	CD28	CD28 molecule	2512	0.36
chrX_21992254_21992490	0.67	SMS	spermine synthase	33209	0.17
chr14_99726709_99727240	0.67	AL109767.1		2311	0.33
chr1_198608588_198608957	0.67	PTPRC	protein tyrosine phosphatase, receptor type, C	480	0.86
chr11_122940168_122940622	0.65	HSPA8	heat shock 70kDa protein 8	6457	0.15
chr4_36245078_36245884	0.64	ARAP2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	80	0.74
chr2_196281841_196281992	0.64	ENSG00000202206	.	96844	0.09
chr17_37932472_37932886	0.62	IKZF3	IKAROS family zinc finger 3 (Aiolos)	1799	0.27
chr2_158295494_158296053	0.60	CYTIP	cytohesin 1 interacting protein	153	0.96
chr3_111261315_111261845	0.59	CD96	CD96 molecule	583	0.82
chr4_84032848_84033051	0.58	PLAC8	placenta-specific 8	1953	0.4
chr12_54891959_54892179	0.58	NCKAP1L	NCK-associated protein 1-like	499	0.73
chr22_40324201_40324352	0.58	GRAP2	GRB2-related adaptor protein 2	1635	0.36
chr5_169720489_169720914	0.58	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	4530	0.26
chrX_150695771_150695922	0.58	PASD1	PAS domain containing 1	36248	0.2
chr14_22968352_22968523	0.58	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	12266	0.1
chr6_71125805_71125956	0.57	RP11-462G2.2		2227	0.31
chr17_38018344_38018495	0.57	IKZF3	IKAROS family zinc finger 3 (Aiolos)	1960	0.26
chr14_88471433_88472132	0.57	GPR65	G protein-coupled receptor 65	314	0.88
chr2_113932280_113932569	0.56	AC016683.5		490	0.59
chr13_40532306_40532606	0.56	ENSG00000212553	.	101092	0.08
chr5_156610422_156610951	0.56	ITK	IL2-inducible T-cell kinase	2849	0.18
chr20_35575234_35575857	0.56	SAMHD1	SAM domain and HD domain 1	4566	0.25
chr3_132628264_132628415	0.56	TMEM108	transmembrane protein 108	128896	0.05
chr13_46755198_46755455	0.56	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	1133	0.45
chr12_9912315_9912520	0.55	CD69	CD69 molecule	1080	0.47
chr11_104904746_104905919	0.55	CASP1	caspase 1, apoptosis-related cysteine peptidase	508	0.77
chr3_30650793_30651257	0.55	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	2932	0.39
chr11_104941725_104942216	0.54	CARD16	caspase recruitment domain family, member 16	25867	0.14
chr1_151130261_151130413	0.54	SCNM1	sodium channel modifier 1	1197	0.22
chr14_22947593_22947744	0.53	TRAJ60	T cell receptor alpha joining 60 (pseudogene)	2372	0.15
chr2_143887583_143887860	0.52	ARHGAP15	Rho GTPase activating protein 15	838	0.72
chr15_60874237_60874501	0.52	RORA	RAR-related orphan receptor A	10371	0.22
chr6_128221212_128221624	0.52	THEMIS	thymocyte selection associated	685	0.81
chr14_22958789_22958996	0.51	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	2721	0.15
chr3_18477156_18477307	0.50	SATB1	SATB homeobox 1	486	0.83
chr2_204801338_204802214	0.50	ICOS	inducible T-cell co-stimulator	273	0.95
chr1_158903283_158903483	0.50	PYHIN1	pyrin and HIN domain family, member 1	2025	0.36
chr2_201238626_201239302	0.50	ENSG00000201649	.	1066	0.5
chr11_104971227_104972126	0.50	CASP1	caspase 1, apoptosis-related cysteine peptidase	482	0.32
chr5_156608669_156608858	0.49	ITK	IL2-inducible T-cell kinase	926	0.47
chr6_152505006_152505157	0.49	SYNE1	spectrin repeat containing, nuclear envelope 1	15582	0.29
chr2_204572133_204572358	0.48	CD28	CD28 molecule	829	0.71
chr10_6102754_6102905	0.48	IL2RA	interleukin 2 receptor, alpha	1424	0.36
chrX_78403845_78404040	0.48	GPR174	G protein-coupled receptor 174	22527	0.28
chr3_43331814_43332301	0.47	SNRK	SNF related kinase	3979	0.23
chr16_86638626_86639076	0.46	FOXL1	forkhead box L1	26736	0.16
chr3_151962421_151962590	0.46	MBNL1	muscleblind-like splicing regulator 1	23324	0.2
chr6_143263290_143263441	0.46	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	2973	0.34
chr8_76807046_76807197	0.45	ENSG00000238595	.	1982	0.49
chrX_135730500_135730717	0.45	CD40LG	CD40 ligand	222	0.93
chr11_121298288_121298439	0.45	SORL1	sortilin-related receptor, L(DLR class) A repeats containing	24549	0.21
chr1_100887767_100887999	0.45	ENSG00000216067	.	43552	0.14
chr1_112013416_112013602	0.45	C1orf162	chromosome 1 open reading frame 162	2905	0.14
chr5_165288349_165288500	0.45	ENSG00000252794	.	251978	0.02
chr10_17548651_17548924	0.45	ST8SIA6	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	52458	0.13
chr1_169678923_169679233	0.44	SELL	selectin L	1761	0.36
chr7_106507057_106507208	0.44	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	1208	0.59
chr15_86235334_86235485	0.44	RP11-815J21.1		8931	0.12
chr7_138790255_138790726	0.44	ZC3HAV1	zinc finger CCCH-type, antiviral 1	3610	0.26
chr14_74724486_74725063	0.44	VSX2	visual system homeobox 2	18599	0.14
chr5_150593261_150593549	0.44	GM2A	GM2 ganglioside activator	1694	0.36
chr14_102278905_102279056	0.44	CTD-2017C7.2		2322	0.22
chr18_60825953_60826104	0.44	RP11-299P2.1		7475	0.24
chr6_108145054_108145346	0.44	SCML4	sex comb on midleg-like 4 (Drosophila)	316	0.93
chr14_22970384_22970535	0.43	TRAJ51	T cell receptor alpha joining 51 (pseudogene)	14288	0.1
chr13_84126063_84126363	0.43	ENSG00000222791	.	253911	0.02
chr6_98415844_98415995	0.43	ENSG00000238367	.	56488	0.18
chr5_77901409_77901560	0.43	LHFPL2	lipoma HMGIC fusion partner-like 2	43164	0.21
chr2_24114630_24115019	0.43	ATAD2B	ATPase family, AAA domain containing 2B	24067	0.18
chr14_100689805_100690076	0.43	YY1	YY1 transcription factor	14695	0.11
chr12_25206187_25206540	0.43	LRMP	lymphoid-restricted membrane protein	689	0.71
chrX_11779384_11779693	0.43	MSL3	male-specific lethal 3 homolog (Drosophila)	1791	0.5
chr13_41591572_41591774	0.43	ELF1	E74-like factor 1 (ets domain transcription factor)	1777	0.37
chr12_54132160_54132404	0.42	CALCOCO1	calcium binding and coiled-coil domain 1	10753	0.17
chr6_37410160_37410312	0.42	CMTR1	cap methyltransferase 1	9240	0.22
chr1_111212990_111213454	0.42	KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	4433	0.21
chr12_49311955_49312141	0.42	FKBP11	FK506 binding protein 11, 19 kDa	6702	0.08
chr9_117690832_117691467	0.42	TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	1548	0.52
chr5_98362961_98363596	0.42	ENSG00000200351	.	90827	0.09
chr1_149579136_149579307	0.41	RP11-353N4.6		2608	0.2
chr3_141249287_141249763	0.41	RASA2-IT1	RASA2 intronic transcript 1 (non-protein coding)	5550	0.26
chr5_156616823_156617066	0.41	ITK	IL2-inducible T-cell kinase	9107	0.13
chr21_35306376_35306527	0.41	LINC00649	long intergenic non-protein coding RNA 649	2933	0.21
chr7_142430441_142430617	0.40	PRSS1	protease, serine, 1 (trypsin 1)	26790	0.17
chr3_52309275_52309582	0.40	WDR82	WD repeat domain 82	2909	0.12
chr8_8727017_8727210	0.40	MFHAS1	malignant fibrous histiocytoma amplified sequence 1	24042	0.18
chr1_24862040_24862255	0.40	ENSG00000266551	.	5943	0.18
chr1_198620819_198621442	0.40	PTPRC	protein tyrosine phosphatase, receptor type, C	12838	0.23
chr12_46063121_46063382	0.40	ARID2	AT rich interactive domain 2 (ARID, RFX-like)	60197	0.15
chr5_176037885_176038043	0.39	GPRIN1	G protein regulated inducer of neurite outgrowth 1	830	0.48
chr15_31622749_31622975	0.39	KLF13	Kruppel-like factor 13	3804	0.36
chr1_198615140_198615291	0.39	PTPRC	protein tyrosine phosphatase, receptor type, C	6923	0.25
chr7_146801323_146801474	0.39	AC006004.1		6697	0.34
chr2_99278961_99279112	0.38	MGAT4A	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A	900	0.64
chr11_117151480_117151734	0.38	BACE1	beta-site APP-cleaving enzyme 1	14594	0.13
chr4_90226799_90226950	0.38	GPRIN3	GPRIN family member 3	2287	0.45
chr12_10019991_10020525	0.38	RP11-290C10.1		632	0.61
chr5_118606885_118607036	0.38	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	2511	0.28
chr22_31685289_31685466	0.38	PIK3IP1	phosphoinositide-3-kinase interacting protein 1	3004	0.15
chr2_143887292_143887566	0.38	ARHGAP15	Rho GTPase activating protein 15	546	0.84
chr11_88068800_88069370	0.38	CTSC	cathepsin C	1816	0.49
chr13_41557403_41557660	0.38	ELF1	E74-like factor 1 (ets domain transcription factor)	1113	0.53
chr7_43626899_43627416	0.37	STK17A	serine/threonine kinase 17a	4493	0.21
chr2_87830138_87830289	0.37	RP11-1399P15.1		52660	0.16
chr13_99966823_99967055	0.37	GPR183	G protein-coupled receptor 183	7280	0.21
chr14_92331424_92331867	0.37	TC2N	tandem C2 domains, nuclear	2228	0.32
chr8_66751055_66751459	0.37	PDE7A	phosphodiesterase 7A	274	0.95
chr14_64974356_64974596	0.37	ZBTB25	zinc finger and BTB domain containing 25	2545	0.17
chr20_49134113_49134959	0.37	PTPN1	protein tyrosine phosphatase, non-receptor type 1	7616	0.17
chr10_47640402_47640757	0.37	ANTXRLP1	anthrax toxin receptor-like pseudogene 1	4212	0.25
chr7_26332124_26332363	0.37	SNX10	sorting nexin 10	431	0.87
chr1_160616915_160617313	0.37	SLAMF1	signaling lymphocytic activation molecule family member 1	29	0.97
chr19_1470719_1471158	0.37	C19orf25	chromosome 19 open reading frame 25	7958	0.07
chr18_60983375_60983526	0.36	RP11-28F1.2		2135	0.26
chr21_32559881_32560032	0.36	TIAM1	T-cell lymphoma invasion and metastasis 1	57417	0.15
chr16_89550769_89551086	0.36	ANKRD11	ankyrin repeat domain 11	5799	0.13
chr5_23012798_23012949	0.36	CDH12	cadherin 12, type 2 (N-cadherin 2)	159142	0.04
chr12_15114929_15115219	0.36	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	412	0.82
chr3_20145563_20145846	0.36	ENSG00000266745	.	33353	0.15
chr7_50350295_50350528	0.36	IKZF1	IKAROS family zinc finger 1 (Ikaros)	2093	0.45
chr5_130603053_130603363	0.36	CDC42SE2	CDC42 small effector 2	3415	0.35
chr13_41555714_41555943	0.36	ELF1	E74-like factor 1 (ets domain transcription factor)	590	0.77
chr2_191929470_191929872	0.36	ENSG00000231858	.	43419	0.12
chr6_10522420_10522571	0.36	GCNT2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	911	0.58
chr3_95425254_95425405	0.36	ENSG00000221477	.	460417	0.01
chr2_109238100_109238434	0.36	LIMS1	LIM and senescent cell antigen-like domains 1	545	0.82
chr14_97924887_97925209	0.36	ENSG00000240730	.	71462	0.14
chr12_55266839_55266990	0.36	MUCL1	mucin-like 1	18593	0.23
chr6_135039787_135039938	0.36	ALDH8A1	aldehyde dehydrogenase 8 family, member A1	210437	0.02
chr3_121373349_121373500	0.35	ENSG00000243544	.	281	0.82
chr1_244488017_244488168	0.35	C1orf100	chromosome 1 open reading frame 100	27845	0.22
chr9_128586563_128586792	0.35	PBX3	pre-B-cell leukemia homeobox 3	40873	0.21
chr6_154568354_154568864	0.35	IPCEF1	interaction protein for cytohesin exchange factors 1	53	0.99
chr6_119398487_119399078	0.35	FAM184A	family with sequence similarity 184, member A	755	0.67
chr5_96294037_96294231	0.35	LNPEP	leucyl/cystinyl aminopeptidase	21	0.98
chr12_111868224_111868441	0.35	SH2B3	SH2B adaptor protein 3	4334	0.21
chr11_104915569_104916017	0.35	CARD16	caspase recruitment domain family, member 16	241	0.92
chrX_135729885_135730036	0.35	CD40LG	CD40 ligand	392	0.84
chr1_113634018_113634169	0.35	LRIG2	leucine-rich repeats and immunoglobulin-like domains 2	18262	0.26
chr3_71351252_71351403	0.35	FOXP1	forkhead box P1	2584	0.35
chr10_46075820_46076565	0.35	MARCH8	membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase	13747	0.25
chr11_118134576_118134833	0.35	MPZL2	myelin protein zero-like 2	293	0.86
chr17_28085648_28085799	0.35	RP11-82O19.1		2398	0.25
chr1_200865204_200865355	0.35	C1orf106	chromosome 1 open reading frame 106	1330	0.42
chr6_159465378_159465638	0.35	TAGAP	T-cell activation RhoGTPase activating protein	542	0.78
chr8_66750529_66750680	0.35	PDE7A	phosphodiesterase 7A	379	0.92
chr19_42056193_42056486	0.35	CEACAM21	carcinoembryonic antigen-related cell adhesion molecule 21	453	0.8
chr21_15917916_15918619	0.35	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	395	0.89
chr15_64391220_64391371	0.34	SNX1	sorting nexin 1	3070	0.19
chr1_70750666_70750817	0.34	SRSF11	serine/arginine-rich splicing factor 11	53510	0.1
chr6_130537052_130537203	0.34	SAMD3	sterile alpha motif domain containing 3	48	0.99
chr4_143488982_143489737	0.34	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	7537	0.34
chr19_54873446_54873661	0.34	LAIR1	leukocyte-associated immunoglobulin-like receptor 1	997	0.38
chr12_62652869_62653097	0.34	FAM19A2	family with sequence similarity 19 (chemokine (C-C motif)-like), member A2	379	0.79
chr1_206731858_206732141	0.34	RASSF5	Ras association (RalGDS/AF-6) domain family member 5	1506	0.37
chr21_32563083_32563234	0.34	TIAM1	T-cell lymphoma invasion and metastasis 1	60619	0.14
chr15_93431332_93431756	0.34	CHD2	chromodomain helicase DNA binding protein 2	5018	0.2
chr14_102291094_102291439	0.34	CTD-2017C7.1		14602	0.14
chr5_100234956_100235107	0.34	ST8SIA4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	3887	0.35
chrX_39185236_39185387	0.34	ENSG00000207122	.	244773	0.02
chr1_32720364_32720515	0.34	LCK	lymphocyte-specific protein tyrosine kinase	3564	0.11
chr10_8179903_8180054	0.33	GATA3	GATA binding protein 3	83209	0.11
chr2_161994699_161994850	0.33	TANK	TRAF family member-associated NFKB activator	1308	0.52
chr5_67580506_67580669	0.33	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	3609	0.36
chr20_4802726_4803481	0.33	RASSF2	Ras association (RalGDS/AF-6) domain family member 2	1188	0.5
chr3_74315841_74315992	0.33	ENSG00000212585	.	100713	0.09
chr9_117567735_117567886	0.33	TNFSF15	tumor necrosis factor (ligand) superfamily, member 15	596	0.78
chr17_43131298_43131449	0.33	DCAKD	dephospho-CoA kinase domain containing	2386	0.18
chr2_112177530_112177803	0.33	ENSG00000266139	.	98998	0.09
chrX_20996388_20996539	0.33	ENSG00000206716	.	236292	0.02
chr4_36243817_36244102	0.33	ARAP2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1602	0.35
chr22_40322756_40322951	0.33	GRAP2	GRB2-related adaptor protein 2	212	0.93
chr18_22040594_22040766	0.33	HRH4	histamine receptor H4	13	0.97
chr1_198614484_198614635	0.32	PTPRC	protein tyrosine phosphatase, receptor type, C	6267	0.26
chr10_51500864_51501147	0.32	AGAP7	ArfGAP with GTPase domain, ankyrin repeat and PH domain 7	14678	0.19
chr3_151918471_151919168	0.32	MBNL1	muscleblind-like splicing regulator 1	67010	0.12
chr11_104787850_104788088	0.32	RP11-693N9.2		7327	0.2
chr12_3979327_3979799	0.32	RP11-664D1.1		1337	0.47
chr14_56879487_56879638	0.32	TMEM260	transmembrane protein 260	75510	0.12
chr3_71537739_71537890	0.32	ENSG00000221264	.	53426	0.14
chr14_47010588_47010739	0.32	RPL10L	ribosomal protein L10-like	110365	0.08
chr6_125401116_125401267	0.32	RNF217	ring finger protein 217	31833	0.2
chr12_40077019_40077550	0.32	C12orf40	chromosome 12 open reading frame 40	57299	0.13
chr2_175459196_175459684	0.32	WIPF1	WAS/WASL interacting protein family, member 1	3053	0.24
chr6_16438021_16438172	0.32	ENSG00000265642	.	9342	0.31
chr3_5178219_5178370	0.32	ARL8B	ADP-ribosylation factor-like 8B	14313	0.17
chr7_138788856_138789199	0.32	ZC3HAV1	zinc finger CCCH-type, antiviral 1	5073	0.23
chr2_237446552_237446703	0.32	ACKR3	atypical chemokine receptor 3	29803	0.19
chr8_39259417_39259568	0.32	ENSG00000252176	.	158964	0.04
chr16_302654_303040	0.32	ITFG3	integrin alpha FG-GAP repeat containing 3	1780	0.2

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of EMX2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.5	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.3	0.8	GO:0002540	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.2	0.9	GO:1904035	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.2	0.6	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.2	0.6	GO:0010459	negative regulation of heart rate(GO:0010459)
0.2	0.8	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.2	0.6	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.2	0.6	GO:0010447	response to acidic pH(GO:0010447)
0.1	0.7	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.1	0.4	GO:1900121	regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.1	0.6	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.1	0.4	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1	1.0	GO:0050860	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1	0.2	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1	0.4	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.1	0.5	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1	0.8	GO:0015671	oxygen transport(GO:0015671)
0.1	0.8	GO:0006491	N-glycan processing(GO:0006491)
0.1	0.5	GO:0032876	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.1	0.8	GO:0043383	negative T cell selection(GO:0043383)
0.1	0.4	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.1	0.3	GO:0060557	positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.1	0.3	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.1	0.2	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1	0.2	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
0.1	0.2	GO:0014889	muscle atrophy(GO:0014889)
0.1	0.2	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.1	0.3	GO:0010508	positive regulation of autophagy(GO:0010508)
0.1	0.1	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.1	0.1	GO:0033689	negative regulation of osteoblast proliferation(GO:0033689)
0.1	0.1	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.1	0.2	GO:0045588	regulation of gamma-delta T cell differentiation(GO:0045586) positive regulation of gamma-delta T cell differentiation(GO:0045588)
0.1	0.2	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.1	0.2	GO:0070265	necrotic cell death(GO:0070265)
0.1	0.1	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1	0.2	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.1	0.1	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.1	0.1	GO:0019049	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1	0.1	GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.1	0.6	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1	0.2	GO:0006922	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.1	0.2	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.1	0.2	GO:0009313	oligosaccharide catabolic process(GO:0009313)
0.1	0.2	GO:0046398	UDP-glucuronate metabolic process(GO:0046398)
0.1	0.2	GO:0001821	histamine secretion(GO:0001821)
0.1	0.6	GO:0043550	regulation of lipid kinase activity(GO:0043550)
0.1	0.2	GO:0045059	positive thymic T cell selection(GO:0045059)
0.1	0.2	GO:0033194	response to hydroperoxide(GO:0033194)
0.1	0.2	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.1	0.2	GO:0035609	C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.1	0.2	GO:0002693	positive regulation of cellular extravasation(GO:0002693)
0.1	0.1	GO:0050857	positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.1	0.2	GO:0002507	tolerance induction(GO:0002507)
0.1	0.2	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.1	0.3	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.1	3.3	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.1	0.1	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1	0.3	GO:0007256	activation of JNKK activity(GO:0007256)
0.1	0.2	GO:0019060	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.1	0.3	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.1	GO:0070295	renal water absorption(GO:0070295)
0.0	0.1	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0	0.1	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0007144	female meiosis I(GO:0007144)
0.0	0.1	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.6	GO:0046834	lipid phosphorylation(GO:0046834)
0.0	1.0	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.1	GO:0001779	natural killer cell differentiation(GO:0001779)
0.0	0.1	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.1	GO:0060789	hair follicle placode formation(GO:0060789)
0.0	1.0	GO:0008633	obsolete activation of pro-apoptotic gene products(GO:0008633)
0.0	0.8	GO:0007032	endosome organization(GO:0007032)
0.0	0.1	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.2	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0048859	formation of anatomical boundary(GO:0048859)
0.0	0.1	GO:0002478	antigen processing and presentation of exogenous peptide antigen(GO:0002478)
0.0	0.1	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.2	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.4	GO:0009435	NAD biosynthetic process(GO:0009435)
0.0	0.1	GO:0009215	purine deoxyribonucleoside triphosphate metabolic process(GO:0009215)
0.0	0.1	GO:0090312	positive regulation of protein deacetylation(GO:0090312)
0.0	0.0	GO:0001787	natural killer cell proliferation(GO:0001787)
0.0	0.1	GO:0007207	phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0	0.1	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0042362	fat-soluble vitamin biosynthetic process(GO:0042362)
0.0	0.2	GO:0071354	cellular response to interleukin-6(GO:0071354)
0.0	0.3	GO:1901222	activation of NF-kappaB-inducing kinase activity(GO:0007250) NIK/NF-kappaB signaling(GO:0038061) regulation of NIK/NF-kappaB signaling(GO:1901222) positive regulation of NIK/NF-kappaB signaling(GO:1901224)
0.0	0.2	GO:0050798	activated T cell proliferation(GO:0050798)
0.0	0.1	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.2	GO:0032733	positive regulation of interleukin-10 production(GO:0032733)
0.0	0.0	GO:0060197	cloaca development(GO:0035844) cloacal septation(GO:0060197)
0.0	0.1	GO:2000192	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0	0.1	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.0	0.1	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.2	GO:0048535	lymph node development(GO:0048535)
0.0	0.2	GO:0032528	microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0	0.1	GO:0072179	nephric duct formation(GO:0072179)
0.0	0.0	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.1	GO:0033522	histone H2A ubiquitination(GO:0033522)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.1	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.1	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0	0.0	GO:0002902	regulation of B cell apoptotic process(GO:0002902) negative regulation of B cell apoptotic process(GO:0002903)
0.0	0.1	GO:0042832	response to protozoan(GO:0001562) defense response to protozoan(GO:0042832)
0.0	0.2	GO:0042159	lipoprotein catabolic process(GO:0042159)
0.0	0.1	GO:0045354	interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.0	GO:0014874	response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.0	0.2	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.3	GO:0042403	thyroid hormone metabolic process(GO:0042403)
0.0	0.7	GO:0071260	cellular response to mechanical stimulus(GO:0071260)
0.0	0.3	GO:0002418	immune response to tumor cell(GO:0002418)
0.0	0.1	GO:0002887	negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.0	0.1	GO:0031573	intra-S DNA damage checkpoint(GO:0031573)
0.0	0.4	GO:0002286	T cell activation involved in immune response(GO:0002286)
0.0	0.2	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.6	GO:0019933	cAMP-mediated signaling(GO:0019933)
0.0	0.1	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.3	GO:0031648	protein destabilization(GO:0031648)
0.0	0.2	GO:0090205	positive regulation of cholesterol metabolic process(GO:0090205)
0.0	0.2	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.1	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.1	GO:0021681	cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.1	GO:0033089	positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0	0.2	GO:0031060	regulation of histone methylation(GO:0031060)
0.0	0.1	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.1	GO:0032957	inositol trisphosphate metabolic process(GO:0032957)
0.0	0.2	GO:0006688	glycosphingolipid biosynthetic process(GO:0006688)
0.0	0.2	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.0	GO:0060057	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0	0.1	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.2	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.1	GO:0090231	regulation of spindle checkpoint(GO:0090231)
0.0	0.4	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0	0.1	GO:0060539	diaphragm development(GO:0060539)
0.0	0.1	GO:0009200	deoxyribonucleoside triphosphate metabolic process(GO:0009200)
0.0	0.1	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.1	GO:0021535	cell migration in hindbrain(GO:0021535)
0.0	0.4	GO:0060334	regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:0035066	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.2	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.6	GO:0031295	lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0	0.1	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.1	GO:0032543	mitochondrial translation(GO:0032543)
0.0	0.3	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.3	GO:0007158	neuron cell-cell adhesion(GO:0007158)
0.0	0.0	GO:0002347	response to tumor cell(GO:0002347)
0.0	0.1	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978)
0.0	0.0	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.1	GO:0051294	establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0	0.0	GO:0033079	immature T cell proliferation(GO:0033079)
0.0	0.1	GO:0072698	protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0	0.1	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.0	0.1	GO:0009732	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.2	GO:0030101	natural killer cell activation(GO:0030101)
0.0	0.2	GO:1903078	positive regulation of establishment of protein localization to plasma membrane(GO:0090004) positive regulation of protein localization to plasma membrane(GO:1903078) positive regulation of protein localization to cell periphery(GO:1904377)
0.0	0.0	GO:0043501	skeletal muscle adaptation(GO:0043501)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.2	GO:0051806	entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.0	0.2	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.0	0.0	GO:0002532	production of molecular mediator involved in inflammatory response(GO:0002532)
0.0	0.1	GO:0018106	peptidyl-histidine phosphorylation(GO:0018106)
0.0	0.1	GO:0016572	histone phosphorylation(GO:0016572)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.0	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.1	GO:0032703	negative regulation of interleukin-2 production(GO:0032703)
0.0	0.1	GO:0006030	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.0	GO:0045581	negative regulation of T cell differentiation(GO:0045581)
0.0	0.0	GO:0045056	transcytosis(GO:0045056)
0.0	0.1	GO:0051775	response to redox state(GO:0051775)
0.0	0.2	GO:0051568	histone H3-K4 methylation(GO:0051568)
0.0	0.0	GO:0043558	regulation of translation in response to stress(GO:0043555) regulation of translational initiation in response to stress(GO:0043558)
0.0	0.0	GO:0045601	regulation of endothelial cell differentiation(GO:0045601)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.0	GO:0019372	lipoxygenase pathway(GO:0019372)
0.0	0.0	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.1	GO:0032988	ribonucleoprotein complex disassembly(GO:0032988)
0.0	0.1	GO:0006287	base-excision repair, gap-filling(GO:0006287)
0.0	0.1	GO:0051918	negative regulation of fibrinolysis(GO:0051918)
0.0	0.0	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.0	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.1	GO:0042447	hormone catabolic process(GO:0042447)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.1	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.0	GO:2000644	regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) regulation of receptor catabolic process(GO:2000644)
0.0	0.1	GO:0048670	regulation of collateral sprouting(GO:0048670)
0.0	0.1	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.1	GO:0009820	alkaloid metabolic process(GO:0009820)
0.0	0.0	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.0	GO:0061046	foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) regulation of branching involved in lung morphogenesis(GO:0061046) positive regulation of branching involved in lung morphogenesis(GO:0061047)
0.0	0.1	GO:0071108	protein K48-linked deubiquitination(GO:0071108)
0.0	0.1	GO:0033261	obsolete regulation of S phase(GO:0033261)
0.0	0.1	GO:0007343	egg activation(GO:0007343)
0.0	0.1	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.0	0.1	GO:0045116	protein neddylation(GO:0045116)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.0	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.1	GO:0050435	beta-amyloid metabolic process(GO:0050435)
0.0	0.1	GO:0070071	proton-transporting two-sector ATPase complex assembly(GO:0070071)
0.0	0.0	GO:0045359	interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.0	0.1	GO:0035283	central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0	0.1	GO:0018202	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) peptidyl-histidine modification(GO:0018202)
0.0	0.1	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367)
0.0	0.0	GO:1901889	negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)
0.0	0.0	GO:0055009	atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009)
0.0	0.0	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
0.0	0.0	GO:1901797	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.0	GO:0071436	sodium ion export(GO:0071436)
0.0	0.0	GO:0045410	positive regulation of interleukin-6 biosynthetic process(GO:0045410)
0.0	0.0	GO:0034371	chylomicron remodeling(GO:0034371)
0.0	0.2	GO:0071044	histone mRNA catabolic process(GO:0071044)
0.0	0.1	GO:0009311	oligosaccharide metabolic process(GO:0009311)
0.0	0.2	GO:0016601	Rac protein signal transduction(GO:0016601)
0.0	0.0	GO:0042977	activation of JAK2 kinase activity(GO:0042977)
0.0	0.0	GO:0016075	rRNA catabolic process(GO:0016075)
0.0	0.1	GO:0001967	suckling behavior(GO:0001967)
0.0	0.0	GO:0033160	positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0	0.0	GO:0043045	DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.0	0.0	GO:0046185	aldehyde catabolic process(GO:0046185)
0.0	0.0	GO:0046877	regulation of saliva secretion(GO:0046877)
0.0	0.0	GO:0032494	response to peptidoglycan(GO:0032494)
0.0	0.2	GO:0001522	pseudouridine synthesis(GO:0001522)
0.0	0.0	GO:0022417	protein maturation by protein folding(GO:0022417)
0.0	0.1	GO:0036230	granulocyte activation(GO:0036230)
0.0	0.1	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.0	0.0	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.0	GO:0070857	regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.0	0.1	GO:0006273	lagging strand elongation(GO:0006273)
0.0	0.2	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0	0.2	GO:0019370	leukotriene biosynthetic process(GO:0019370)
0.0	0.1	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)
0.0	0.1	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.0	0.1	GO:0003351	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.1	GO:0046519	sphingoid metabolic process(GO:0046519)
0.0	0.0	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.1	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0	0.0	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.1	GO:0034227	tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) tRNA thio-modification(GO:0034227)
0.0	0.1	GO:0071230	cellular response to amino acid stimulus(GO:0071230)
0.0	0.0	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.0	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.0	GO:0060770	regulation of epithelial cell proliferation involved in prostate gland development(GO:0060768) negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.1	GO:0048488	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.0	GO:0014002	astrocyte development(GO:0014002)
0.0	0.1	GO:0007494	midgut development(GO:0007494)
0.0	0.0	GO:0001973	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.0	GO:0035269	protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.0	0.0	GO:0072216	positive regulation of metanephros development(GO:0072216)
0.0	0.1	GO:0042797	5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0	0.1	GO:0006265	DNA topological change(GO:0006265)
0.0	0.0	GO:0043276	anoikis(GO:0043276)
0.0	0.7	GO:0006921	cellular component disassembly involved in execution phase of apoptosis(GO:0006921) execution phase of apoptosis(GO:0097194)
0.0	0.2	GO:0032480	negative regulation of type I interferon production(GO:0032480)
0.0	0.1	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	0.2	GO:0045947	negative regulation of translational initiation(GO:0045947)
0.0	0.1	GO:0042448	progesterone metabolic process(GO:0042448)
0.0	0.0	GO:0048935	peripheral nervous system neuron development(GO:0048935)
0.0	0.1	GO:0016584	nucleosome positioning(GO:0016584)
0.0	0.3	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0	0.2	GO:0030837	negative regulation of actin filament polymerization(GO:0030837)
0.0	0.0	GO:0060972	left/right pattern formation(GO:0060972)
0.0	0.0	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0	0.0	GO:0072393	microtubule anchoring at microtubule organizing center(GO:0072393)
0.0	0.3	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:0000288)
0.0	0.2	GO:0006730	one-carbon metabolic process(GO:0006730)
0.0	0.0	GO:0045078	positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0	0.0	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.2	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.0	GO:0044320	cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0	0.0	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.0	GO:0010898	positive regulation of triglyceride catabolic process(GO:0010898)
0.0	0.0	GO:0045824	negative regulation of innate immune response(GO:0045824)
0.0	0.0	GO:0031558	obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0	0.1	GO:0050853	B cell receptor signaling pathway(GO:0050853)
0.0	0.0	GO:0044340	canonical Wnt signaling pathway involved in regulation of cell proliferation(GO:0044340)
0.0	0.2	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0	0.1	GO:0000050	urea cycle(GO:0000050)
0.0	0.1	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0	0.5	GO:0071357	type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0	0.0	GO:0048240	sperm capacitation(GO:0048240)
0.0	0.0	GO:0060484	lung-associated mesenchyme development(GO:0060484)
0.0	0.6	GO:0071158	positive regulation of cell cycle arrest(GO:0071158)
0.0	0.0	GO:0021631	optic nerve morphogenesis(GO:0021631)
0.0	0.0	GO:0048752	semicircular canal morphogenesis(GO:0048752) semicircular canal development(GO:0060872)
0.0	0.0	GO:0021937	cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.0	0.0	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.1	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.0	0.2	GO:0051865	protein autoubiquitination(GO:0051865)
0.0	0.4	GO:0031124	mRNA 3'-end processing(GO:0031124)
0.0	0.1	GO:0000012	single strand break repair(GO:0000012)
0.0	0.0	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.0	GO:0033866	nucleoside bisphosphate biosynthetic process(GO:0033866) ribonucleoside bisphosphate biosynthetic process(GO:0034030) purine nucleoside bisphosphate biosynthetic process(GO:0034033)
0.0	0.4	GO:0051607	defense response to virus(GO:0051607)
0.0	0.1	GO:0010833	telomere maintenance via telomere lengthening(GO:0010833)
0.0	0.0	GO:0090023	positive regulation of neutrophil chemotaxis(GO:0090023) positive regulation of neutrophil migration(GO:1902624)
0.0	0.0	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.2	GO:0043484	regulation of RNA splicing(GO:0043484)
0.0	0.3	GO:0006903	vesicle targeting(GO:0006903)
0.0	0.1	GO:0015884	folic acid transport(GO:0015884)
0.0	0.1	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0	0.0	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.0	0.0	GO:0043441	acetoacetic acid biosynthetic process(GO:0043441)
0.0	0.0	GO:2000573	positive regulation of telomerase activity(GO:0051973) positive regulation of DNA biosynthetic process(GO:2000573)
0.0	0.1	GO:0048069	eye pigmentation(GO:0048069)
0.0	0.0	GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin(GO:0001991)
0.0	0.1	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0	0.0	GO:0046477	glycosylceramide catabolic process(GO:0046477)
0.0	0.0	GO:0032515	negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0	0.0	GO:0060856	establishment of blood-brain barrier(GO:0060856)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.2	0.6	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	0.9	GO:0001891	phagocytic cup(GO:0001891)
0.1	0.7	GO:0031264	death-inducing signaling complex(GO:0031264)
0.1	0.6	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.1	0.4	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	0.3	GO:0072487	MSL complex(GO:0072487)
0.1	0.5	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.1	0.3	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	1.2	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.1	0.5	GO:0042101	T cell receptor complex(GO:0042101)
0.1	0.2	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.1	0.2	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.0	0.5	GO:0001772	immunological synapse(GO:0001772)
0.0	0.2	GO:0070695	FHF complex(GO:0070695)
0.0	0.5	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.3	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.1	GO:0031904	endosome lumen(GO:0031904)
0.0	0.2	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.3	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.3	GO:0070822	Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822)
0.0	0.2	GO:0031211	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.2	GO:0000444	MIS12/MIND type complex(GO:0000444)
0.0	0.2	GO:0045179	apical cortex(GO:0045179)
0.0	0.2	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.1	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	0.1	GO:0071062	alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.2	GO:0042827	platelet dense granule(GO:0042827)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.1	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.1	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.5	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.1	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.0	0.5	GO:0030057	desmosome(GO:0030057)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.5	GO:1903293	protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0	0.1	GO:0005883	neurofilament(GO:0005883)
0.0	0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.0	GO:0030312	external encapsulating structure(GO:0030312)
0.0	0.3	GO:0043209	myelin sheath(GO:0043209)
0.0	0.1	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.1	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.0	0.1	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.1	GO:0001740	Barr body(GO:0001740)
0.0	0.2	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.1	GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0	0.1	GO:0005838	proteasome regulatory particle(GO:0005838)
0.0	0.0	GO:1903561	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.1	GO:0032009	early phagosome(GO:0032009)
0.0	2.3	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	0.1	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.4	GO:0005637	nuclear inner membrane(GO:0005637)
0.0	0.4	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.1	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	0.1	GO:0035253	ciliary rootlet(GO:0035253)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.9	GO:0016605	PML body(GO:0016605)
0.0	0.1	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.7	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.0	0.2	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.0	GO:0005827	polar microtubule(GO:0005827)
0.0	0.0	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.1	GO:0005652	nuclear lamina(GO:0005652)
0.0	0.2	GO:0042627	chylomicron(GO:0042627)
0.0	0.1	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.2	GO:0045335	phagocytic vesicle(GO:0045335)
0.0	0.2	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.1	GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0	0.1	GO:0031428	box C/D snoRNP complex(GO:0031428)
0.0	0.1	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0	0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.2	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0	0.1	GO:0045257	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0	0.1	GO:0045239	tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0	0.1	GO:0033391	chromatoid body(GO:0033391)
0.0	0.0	GO:0033185	mannosyltransferase complex(GO:0031501) dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0	0.1	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.0	0.2	GO:0005849	mRNA cleavage factor complex(GO:0005849)
0.0	0.6	GO:0055037	recycling endosome(GO:0055037)
0.0	0.4	GO:0016592	mediator complex(GO:0016592)
0.0	0.1	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	0.2	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0	0.1	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.0	0.0	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.1	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.0	0.1	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.1	GO:0005869	dynactin complex(GO:0005869)
0.0	0.1	GO:0031528	microvillus membrane(GO:0031528)
0.0	0.1	GO:0042599	lamellar body(GO:0042599)
0.0	0.1	GO:0000125	PCAF complex(GO:0000125)
0.0	0.0	GO:0032449	CBM complex(GO:0032449)
0.0	0.1	GO:0090568	NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.0	0.2	GO:0030530	obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0	0.0	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0	0.2	GO:0005776	autophagosome(GO:0005776)
0.0	0.1	GO:0005744	mitochondrial inner membrane presequence translocase complex(GO:0005744)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.8	GO:0050544	arachidonic acid binding(GO:0050544)
0.2	0.6	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1	0.4	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	0.7	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1	0.4	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1	0.3	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.1	0.3	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1	0.4	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.1	2.2	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1	1.7	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.1	1.5	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1	0.2	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.1	0.2	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.1	0.5	GO:0001784	phosphotyrosine binding(GO:0001784)
0.1	1.1	GO:0004697	protein kinase C activity(GO:0004697)
0.1	0.4	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1	0.2	GO:0004515	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.1	0.3	GO:0016004	phospholipase activator activity(GO:0016004)
0.1	0.2	GO:0098847	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.1	0.3	GO:0070087	chromo shadow domain binding(GO:0070087)
0.1	0.2	GO:0030284	estrogen receptor activity(GO:0030284)
0.1	0.8	GO:0005344	oxygen transporter activity(GO:0005344)
0.1	0.2	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.1	0.4	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.1	0.2	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1	0.2	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1	0.4	GO:0005521	lamin binding(GO:0005521)
0.1	0.2	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.1	0.9	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.1	0.7	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1	0.5	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.1	0.2	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.1	0.7	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.1	0.3	GO:0004969	histamine receptor activity(GO:0004969)
0.1	0.1	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894)
0.0	0.1	GO:0015254	glycerol channel activity(GO:0015254)
0.0	0.3	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.3	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	2.3	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.2	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.4	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	1.8	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0	0.2	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.1	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.2	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.1	GO:0050698	proteoglycan sulfotransferase activity(GO:0050698)
0.0	0.2	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.2	GO:0001846	opsonin binding(GO:0001846)
0.0	0.1	GO:0060229	lipase activator activity(GO:0060229)
0.0	0.2	GO:0070513	death domain binding(GO:0070513)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.0	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0016454	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.1	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.3	GO:0008641	small protein activating enzyme activity(GO:0008641)
0.0	0.0	GO:0035197	siRNA binding(GO:0035197)
0.0	0.1	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0070410	co-SMAD binding(GO:0070410)
0.0	0.6	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.3	GO:0005522	profilin binding(GO:0005522)
0.0	0.2	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.2	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.1	GO:0004875	complement receptor activity(GO:0004875)
0.0	0.2	GO:0008242	omega peptidase activity(GO:0008242)
0.0	0.1	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.2	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.1	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.1	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.1	GO:0004104	cholinesterase activity(GO:0004104)
0.0	0.1	GO:0099602	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0	0.5	GO:0043621	protein self-association(GO:0043621)
0.0	1.6	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	0.1	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.2	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.3	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.2	GO:0015385	sodium:proton antiporter activity(GO:0015385)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.1	GO:0001537	N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.3	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.1	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.1	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.8	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0015166	polyol transmembrane transporter activity(GO:0015166)
0.0	0.4	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.3	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.1	GO:0070569	uridylyltransferase activity(GO:0070569)
0.0	0.1	GO:0008384	IkappaB kinase activity(GO:0008384)
0.0	0.1	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.7	GO:0003823	antigen binding(GO:0003823)
0.0	0.2	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.2	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.1	GO:0005113	patched binding(GO:0005113)
0.0	0.6	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.2	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.2	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.2	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.2	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.1	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.2	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.1	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.1	GO:0030354	melanin-concentrating hormone activity(GO:0030354)
0.0	0.1	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	0.2	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.1	GO:0004142	diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0	0.3	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.1	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.2	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.0	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.0	0.1	GO:0004703	G-protein coupled receptor kinase activity(GO:0004703)
0.0	0.1	GO:0004803	transposase activity(GO:0004803)
0.0	0.1	GO:0016307	phosphatidylinositol phosphate kinase activity(GO:0016307)
0.0	0.1	GO:0046625	sphingolipid binding(GO:0046625)
0.0	0.1	GO:0051734	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.2	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.2	GO:0032393	MHC class I receptor activity(GO:0032393)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.2	GO:0003711	obsolete transcription elongation regulator activity(GO:0003711)
0.0	0.1	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.1	GO:0003896	DNA primase activity(GO:0003896)
0.0	0.1	GO:0008517	folic acid transporter activity(GO:0008517)
0.0	0.1	GO:0000405	bubble DNA binding(GO:0000405)
0.0	0.1	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.1	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0	0.0	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.1	GO:0034190	apolipoprotein receptor binding(GO:0034190)
0.0	0.2	GO:0008373	sialyltransferase activity(GO:0008373)
0.0	0.1	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	0.0	GO:0015924	mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0	0.0	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0	0.0	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.0	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.0	0.0	GO:0033613	activating transcription factor binding(GO:0033613)
0.0	0.0	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.3	GO:0005484	SNAP receptor activity(GO:0005484)
0.0	0.0	GO:0019237	centromeric DNA binding(GO:0019237)
0.0	0.0	GO:0004980	melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.0	GO:0002060	purine nucleobase binding(GO:0002060)
0.0	0.2	GO:0042809	vitamin D receptor binding(GO:0042809)
0.0	0.0	GO:0035014	phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.1	GO:0032452	histone demethylase activity(GO:0032452)
0.0	0.3	GO:0001104	RNA polymerase II transcription cofactor activity(GO:0001104)
0.0	0.1	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0	0.1	GO:0000104	succinate dehydrogenase activity(GO:0000104)
0.0	0.1	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.2	GO:0003756	protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0	0.0	GO:0070215	obsolete MDM2 binding(GO:0070215)
0.0	0.0	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0	0.1	GO:0003945	N-acetyllactosamine synthase activity(GO:0003945)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.2	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.1	GO:0016423	tRNA (guanine) methyltransferase activity(GO:0016423)
0.0	0.2	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.0	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.1	GO:0030371	translation repressor activity(GO:0030371)
0.0	0.0	GO:0018685	alkane 1-monooxygenase activity(GO:0018685)
0.0	0.0	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.0	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.0	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.2	GO:0004806	triglyceride lipase activity(GO:0004806)
0.0	0.0	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.3	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.0	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.0	0.0	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0019864	IgG binding(GO:0019864)
0.0	0.0	GO:0015440	oligopeptide-transporting ATPase activity(GO:0015421) peptide-transporting ATPase activity(GO:0015440)
0.0	0.0	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.1	GO:0003709	obsolete RNA polymerase III transcription factor activity(GO:0003709)
0.0	0.2	GO:0004004	ATP-dependent RNA helicase activity(GO:0004004)
0.0	0.0	GO:0004476	mannose-6-phosphate isomerase activity(GO:0004476)
0.0	0.1	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0	0.0	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.0	GO:0050682	AF-2 domain binding(GO:0050682)
0.0	0.1	GO:0016681	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0	0.1	GO:0031013	troponin I binding(GO:0031013)
0.0	0.2	GO:0043014	alpha-tubulin binding(GO:0043014)
0.0	0.3	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.0	0.1	GO:0016421	CoA carboxylase activity(GO:0016421)
0.0	0.1	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0	0.0	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.2	GO:0070330	aromatase activity(GO:0070330)
0.0	0.1	GO:0005527	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.1	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.0	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.0	GO:0015923	mannosidase activity(GO:0015923)
0.0	0.0	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0005537	mannose binding(GO:0005537)
0.0	0.0	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.0	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.1	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.0	0.2	GO:0016860	intramolecular oxidoreductase activity(GO:0016860)
0.0	0.0	GO:0070492	oligosaccharide binding(GO:0070492)
0.0	0.0	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0	0.1	GO:0043295	glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0	2.8	GO:0016563	obsolete transcription activator activity(GO:0016563)
0.0	0.0	GO:0043495	protein anchor(GO:0043495)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.2	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.1	1.0	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1	2.5	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.1	1.1	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	0.9	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.1	2.4	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.1	1.2	PID CD40 PATHWAY	CD40/CD40L signaling
0.1	0.8	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1	1.2	PID IL2 1PATHWAY	IL2-mediated signaling events
0.0	1.1	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	0.0	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	1.8	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.0	0.5	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	0.5	PID ERBB1 RECEPTOR PROXIMAL PATHWAY	EGF receptor (ErbB1) signaling pathway
0.0	0.4	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.0	0.1	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	0.1	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0	0.2	PID TRAIL PATHWAY	TRAIL signaling pathway
0.0	1.0	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	0.2	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	0.5	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.0	0.4	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.7	PID IL12 2PATHWAY	IL12-mediated signaling events
0.0	0.3	PID IL3 PATHWAY	IL3-mediated signaling events
0.0	0.8	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.0	ST STAT3 PATHWAY	STAT3 Pathway
0.0	0.0	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.0	0.4	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	0.1	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.0	0.0	SIG CHEMOTAXIS	Genes related to chemotaxis
0.0	0.1	PID S1P S1P2 PATHWAY	S1P2 pathway
0.0	0.1	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	0.1	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	0.1	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	0.2	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	0.0	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.3	PID BCR 5PATHWAY	BCR signaling pathway
0.0	0.2	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	0.0	PID ERBB4 PATHWAY	ErbB4 signaling events
0.0	0.2	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.0	0.2	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.0	0.2	PID RAS PATHWAY	Regulation of Ras family activation
0.0	0.2	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	0.0	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.0	0.6	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	0.1	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.2	PID ATM PATHWAY	ATM pathway
0.0	0.2	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.0	0.1	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.0	0.1	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0	0.1	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.0	0.1	PID S1P S1P1 PATHWAY	S1P1 pathway
0.0	0.1	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	0.0	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	0.1	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.0	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
0.0	0.1	PID EPO PATHWAY	EPO signaling pathway
0.0	0.1	ST GA12 PATHWAY	G alpha 12 Pathway
0.0	0.1	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	0.1	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	0.2	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.1	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.1	2.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	1.0	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.1	0.8	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.1	1.0	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.1	0.1	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
0.1	1.0	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	0.7	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.1	1.6	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.1	2.9	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.6	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	1.1	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.2	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.0	0.6	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.3	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	1.4	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.0	0.1	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0	0.6	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.2	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.0	0.1	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.1	REACTOME P75NTR SIGNALS VIA NFKB	Genes involved in p75NTR signals via NF-kB
0.0	0.2	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.6	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.5	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0	0.3	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.4	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.5	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.4	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.9	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.1	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.8	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.0	2.7	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	0.6	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	0.3	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	0.3	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	0.1	REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS	Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0	0.4	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.1	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0	0.3	REACTOME TCR SIGNALING	Genes involved in TCR signaling
0.0	0.0	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	0.1	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.1	REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.0	0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.2	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0	0.0	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	0.2	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.3	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.4	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.1	REACTOME IL 3 5 AND GM CSF SIGNALING	Genes involved in Interleukin-3, 5 and GM-CSF signaling
0.0	0.3	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.0	0.8	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0	0.2	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.0	0.1	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0	0.8	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	0.0	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.0	0.2	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.1	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.3	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	0.2	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.2	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.0	0.2	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.1	REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION	Genes involved in Cleavage of Growing Transcript in the Termination Region
0.0	0.2	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.0	0.2	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.0	REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT	Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0	0.4	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0	0.2	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.0	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0	0.0	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.0	0.4	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.0	0.3	REACTOME AMYLOIDS	Genes involved in Amyloids
0.0	0.1	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.0	0.2	REACTOME GAB1 SIGNALOSOME	Genes involved in GAB1 signalosome
0.0	0.0	REACTOME G2 M CHECKPOINTS	Genes involved in G2/M Checkpoints
0.0	0.2	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	0.7	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.0	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.0	0.0	REACTOME PKB MEDIATED EVENTS	Genes involved in PKB-mediated events
0.0	0.1	REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0	0.0	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.1	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.1	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.0	REACTOME MRNA CAPPING	Genes involved in mRNA Capping
0.0	0.2	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.0	0.0	REACTOME SIGNALLING TO P38 VIA RIT AND RIN	Genes involved in Signalling to p38 via RIT and RIN

Results for EMX2

Z-value: 1.89

Motif logo

Transcription factors associated with EMX2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the EMX2 motif across conditions

Conditions sorted by the z-value of the EMX2 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of EMX2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: