Project

ENCODE: H3K4me3 ChIP-Seq of primary human cells

Navigation

Downloads

Results for EN1_ESX1_GBX1

Z-value: 0.63

Motif logo

Transcription factors associated with EN1_ESX1_GBX1

Gene Symbol	Gene ID	Gene Info
EN1 Ensembl NCBI GeneCards UniProt	ENSG00000163064.6	engrailed homeobox 1
ESX1 Ensembl NCBI GeneCards UniProt	ENSG00000123576.5	ESX homeobox 1
GBX1 Ensembl NCBI GeneCards UniProt	ENSG00000164900.4	gastrulation brain homeobox 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr2_119592973_119593692	EN1	11922	0.282041	-0.67	4.9e-02	Click!
chr2_119532507_119532686	EN1	72658	0.123378	-0.67	4.9e-02	Click!
chr2_119587702_119587853	EN1	17477	0.269144	-0.63	6.6e-02	Click!
chr2_119592778_119592929	EN1	12401	0.280898	-0.62	7.7e-02	Click!
chr2_119604243_119604424	EN1	921	0.706043	-0.56	1.2e-01	Click!
chrX_103498696_103498850	ESX1	841	0.709189	-0.86	2.8e-03	Click!
chrX_103498922_103499139	ESX1	584	0.819996	-0.84	4.8e-03	Click!
chrX_103499699_103499850	ESX1	160	0.969949	-0.66	5.4e-02	Click!
chrX_103637379_103637530	ESX1	137840	0.047066	-0.62	7.2e-02	Click!
chrX_103636911_103637062	ESX1	137372	0.047329	-0.52	1.5e-01	Click!
chr7_150864776_150864952	GBX1	229	0.877243	-0.62	7.3e-02	Click!
chr7_150864968_150865398	GBX1	548	0.636055	-0.56	1.2e-01	Click!
chr7_150864129_150864733	GBX1	204	0.892973	-0.55	1.2e-01	Click!

Activity of the EN1_ESX1_GBX1 motif across conditions

Conditions sorted by the z-value of the EN1_ESX1_GBX1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr7_139555848_139556033	0.60	TBXAS1	thromboxane A synthase 1 (platelet)	26830	0.22
chr5_77147504_77148481	0.52	TBCA	tubulin folding cofactor A	16612	0.28
chr9_128521797_128522422	0.48	PBX3	pre-B-cell leukemia homeobox 3	11631	0.27
chr17_66289131_66289282	0.44	ARSG	arylsulfatase G	1547	0.31
chr15_75080868_75081404	0.43	ENSG00000264386	.	38	0.76
chrX_30594869_30596024	0.43	CXorf21	chromosome X open reading frame 21	515	0.84
chr15_55547653_55548107	0.42	RAB27A	RAB27A, member RAS oncogene family	6647	0.22
chr11_122940168_122940622	0.41	HSPA8	heat shock 70kDa protein 8	6457	0.15
chr2_88124610_88124761	0.40	RGPD2	RANBP2-like and GRIP domain containing 2	601	0.82
chr6_154568354_154568864	0.40	IPCEF1	interaction protein for cytohesin exchange factors 1	53	0.99
chrY_15016828_15017148	0.39	DDX3Y	DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked	246	0.96
chr11_122597673_122598179	0.38	ENSG00000239079	.	907	0.67
chr11_75603669_75603820	0.38	UVRAG	UV radiation resistance associated	14296	0.14
chr12_10281805_10282201	0.38	CLEC7A	C-type lectin domain family 7, member A	678	0.6
chr12_120105804_120106659	0.38	PRKAB1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	562	0.74
chr21_39667815_39667966	0.37	KCNJ15	potassium inwardly-rectifying channel, subfamily J, member 15	589	0.84
chr5_88484775_88484926	0.36	MEF2C-AS1	MEF2C antisense RNA 1	223158	0.02
chr1_66799510_66799957	0.36	PDE4B	phosphodiesterase 4B, cAMP-specific	1861	0.5
chr6_159464766_159465080	0.34	TAGAP	T-cell activation RhoGTPase activating protein	1127	0.51
chr21_15917916_15918619	0.34	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	395	0.89
chr6_2222723_2222882	0.34	GMDS	GDP-mannose 4,6-dehydratase	23124	0.28
chr11_61158553_61158704	0.34	TMEM216	transmembrane protein 216	531	0.65
chr5_70314152_70314347	0.33	NAIP	NLR family, apoptosis inhibitory protein	2288	0.36
chr5_69760327_69760484	0.33	RP11-497H16.7		8870	0.28
chr18_13464907_13465379	0.33	LDLRAD4	low density lipoprotein receptor class A domain containing 4	129	0.93
chr10_70850849_70851349	0.32	SRGN	serglycin	3225	0.25
chr6_27099516_27099912	0.32	HIST1H2BJ	histone cluster 1, H2bj	613	0.5
chr17_18204377_18204528	0.32	TOP3A	topoisomerase (DNA) III alpha	1531	0.27
chr5_68905149_68905341	0.32	RP11-848G14.2		8895	0.19
chr1_51442241_51442392	0.32	CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	6700	0.22
chr3_128950544_128950778	0.32	COPG1	coatomer protein complex, subunit gamma 1	17788	0.14
chr17_40400288_40400799	0.31	RP11-358B23.5		20062	0.1
chr8_134086774_134086935	0.31	SLA	Src-like-adaptor	14251	0.23
chr1_169679248_169679951	0.31	SELL	selectin L	1240	0.48
chr14_77873229_77873401	0.30	FKSG61		9426	0.11
chr3_101568772_101569567	0.30	NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	62	0.98
chr6_26198173_26198564	0.30	HIST1H3D	histone cluster 1, H3d	890	0.22
chr7_73509063_73509569	0.30	LIMK1	LIM domain kinase 1	1907	0.33
chrX_9801459_9801610	0.30	ENSG00000206844	.	41207	0.15
chr5_131762557_131762944	0.30	AC116366.5		344	0.83
chr10_7526759_7527322	0.29	ENSG00000207453	.	1731	0.45
chr13_77319930_77320170	0.29	KCTD12	potassium channel tetramerization domain containing 12	140475	0.05
chr1_225610206_225610357	0.29	LBR	lamin B receptor	5318	0.2
chr7_26141262_26141558	0.29	ENSG00000266430	.	41451	0.15
chr2_68594752_68594961	0.29	AC015969.3		2140	0.26
chr1_28267591_28267742	0.29	SMPDL3B	sphingomyelin phosphodiesterase, acid-like 3B	6045	0.13
chr2_136876136_136876323	0.29	CXCR4	chemokine (C-X-C motif) receptor 4	494	0.87
chr6_36215434_36215585	0.28	PNPLA1	patatin-like phospholipase domain containing 1	4529	0.21
chr5_171560548_171560699	0.28	ENSG00000266671	.	52643	0.12
chrX_78400540_78401325	0.28	GPR174	G protein-coupled receptor 174	25537	0.27
chr12_65013240_65013416	0.28	ENSG00000207546	.	2961	0.17
chr1_239883177_239883989	0.28	CHRM3	cholinergic receptor, muscarinic 3	740	0.59
chr13_46745397_46745548	0.28	ENSG00000240767	.	1589	0.32
chr17_28085648_28085799	0.28	RP11-82O19.1		2398	0.25
chr1_184121923_184122452	0.28	ENSG00000199840	.	18770	0.25
chr12_49627195_49627425	0.28	TUBA1C	tubulin, alpha 1c	5601	0.13
chr20_44634106_44634271	0.28	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	3359	0.16
chr9_120467573_120467933	0.28	TLR4	toll-like receptor 4	1103	0.51
chr17_10601145_10601947	0.28	ADPRM	ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent	635	0.41
chr12_7985471_7986071	0.27	SLC2A14	solute carrier family 2 (facilitated glucose transporter), member 14	359	0.8
chr14_88471433_88472132	0.27	GPR65	G protein-coupled receptor 65	314	0.88
chr2_158299843_158300108	0.27	CYTIP	cytohesin 1 interacting protein	679	0.68
chr2_64369947_64371114	0.27	AC074289.1		157	0.93
chr8_102802981_102803132	0.27	NCALD	neurocalcin delta	119	0.98
chrX_119737965_119739054	0.27	MCTS1	malignant T cell amplified sequence 1	333	0.88
chr8_12986347_12986498	0.27	DLC1	deleted in liver cancer 1	4561	0.27
chr3_3859837_3859988	0.27	LRRN1	leucine rich repeat neuronal 1	18791	0.29
chr1_158788907_158789058	0.27	MNDA	myeloid cell nuclear differentiation antigen	12125	0.17
chr2_176322753_176322904	0.27	ENSG00000221347	.	127727	0.05
chr18_65188257_65188408	0.27	DSEL	dermatan sulfate epimerase-like	4115	0.29
chr17_75456326_75456913	0.27	SEPT9	septin 9	4171	0.18
chr8_116460480_116460631	0.27	TRPS1	trichorhinophalangeal syndrome I	43893	0.19
chr6_32158116_32158500	0.27	PBX2	pre-B-cell leukemia homeobox 2	345	0.7
chrY_15815919_15816489	0.27	TMSB4Y	thymosin beta 4, Y-linked	757	0.72
chr5_149791368_149791565	0.27	CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	829	0.6
chr13_31310422_31310683	0.26	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	907	0.71
chr1_198627689_198627922	0.26	RP11-553K8.5		8385	0.25
chr11_20179312_20179463	0.26	DBX1	developing brain homeobox 1	2483	0.35
chr2_175458036_175458370	0.26	WIPF1	WAS/WASL interacting protein family, member 1	4290	0.21
chr13_31312055_31312206	0.26	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	2485	0.4
chr1_66802476_66802627	0.26	PDE4B	phosphodiesterase 4B, cAMP-specific	4679	0.34
chr17_75955874_75956555	0.26	ENSG00000238898	.	40034	0.14
chr1_209930701_209930998	0.26	TRAF3IP3	TRAF3 interacting protein 3	994	0.46
chr2_192540821_192541028	0.26	NABP1	nucleic acid binding protein 1	1938	0.47
chr7_106507255_106507406	0.25	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	1406	0.54
chr1_200987607_200987758	0.25	KIF21B	kinesin family member 21B	4854	0.21
chr14_70111468_70111619	0.25	KIAA0247	KIAA0247	33230	0.18
chr1_60036467_60036618	0.25	FGGY	FGGY carbohydrate kinase domain containing	16952	0.29
chr4_185741986_185742137	0.25	ACSL1	acyl-CoA synthetase long-chain family member 1	5127	0.2
chr11_33952138_33952289	0.25	LMO2	LIM domain only 2 (rhombotin-like 1)	38377	0.16
chrY_2804248_2804778	0.25	ZFY	zinc finger protein, Y-linked	967	0.67
chr2_131099802_131100208	0.25	CCDC115	coiled-coil domain containing 115	83	0.67
chr17_29639732_29640055	0.25	EVI2B	ecotropic viral integration site 2B	1209	0.36
chr1_88150357_88150552	0.25	ENSG00000199318	.	231398	0.02
chr3_156893095_156894129	0.24	ENSG00000243176	.	476	0.72
chr4_36245078_36245884	0.24	ARAP2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	80	0.74
chr20_43110715_43110866	0.24	TTPAL	tocopherol (alpha) transfer protein-like	6230	0.13
chr3_194821900_194822051	0.24	XXYLT1-AS1	XXYLT1 antisense RNA 1	6658	0.17
chr13_41555714_41555943	0.24	ELF1	E74-like factor 1 (ets domain transcription factor)	590	0.77
chr17_25622078_25622646	0.24	WSB1	WD repeat and SOCS box containing 1	990	0.48
chr9_129252632_129253068	0.24	ENSG00000221768	.	40420	0.14
chr16_50059050_50060305	0.24	CNEP1R1	CTD nuclear envelope phosphatase 1 regulatory subunit 1	246	0.93
chr1_29253817_29254129	0.24	EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	12882	0.18
chr13_73613878_73614029	0.24	KLF5	Kruppel-like factor 5 (intestinal)	15161	0.23
chr12_133347795_133347946	0.24	ANKLE2	ankyrin repeat and LEM domain containing 2	9396	0.15
chr2_143887292_143887566	0.24	ARHGAP15	Rho GTPase activating protein 15	546	0.84
chr13_21050204_21050392	0.24	ENSG00000263978	.	42313	0.15
chr7_135656834_135656985	0.24	MTPN	myotrophin	5155	0.19
chr3_174044116_174044267	0.23	NAALADL2	N-acetylated alpha-linked acidic dipeptidase-like 2	114586	0.07
chr17_14652311_14652462	0.23	HS3ST3B1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1	447986	0.01
chr5_100002492_100002643	0.23	ENSG00000207269	.	66195	0.14
chr7_101361201_101361398	0.23	MYL10	myosin, light chain 10, regulatory	88723	0.08
chr5_126094279_126094440	0.23	ENSG00000252185	.	3250	0.29
chr2_70144352_70144560	0.23	MXD1	MAX dimerization protein 1	2136	0.21
chr9_137029602_137029922	0.23	ENSG00000221676	.	76	0.97
chr2_64500903_64501472	0.23	AC074289.1		45585	0.16
chr14_32672268_32672419	0.23	ENSG00000202337	.	132	0.94
chr7_6114490_6114641	0.23	ENSG00000264605	.	8171	0.11
chr22_40858929_40859404	0.23	MKL1	megakaryoblastic leukemia (translocation) 1	256	0.92
chr14_90187580_90187856	0.23	ENSG00000200312	.	8863	0.23
chr13_105792322_105792542	0.23	DAOA	D-amino acid oxidase activator	326160	0.01
chr5_74615521_74615672	0.23	HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase	16558	0.19
chr2_68993241_68993423	0.23	ARHGAP25	Rho GTPase activating protein 25	8601	0.25
chr15_69074948_69075145	0.23	ENSG00000265195	.	19218	0.22
chrX_10066246_10067411	0.23	WWC3	WWC family member 3	35329	0.15
chr4_154448027_154448178	0.23	KIAA0922	KIAA0922	28946	0.22
chr5_79919561_79919712	0.23	CTC-325J23.2		7773	0.17
chr4_147027155_147027306	0.23	ENSG00000216055	.	16206	0.24
chr3_112277196_112277347	0.23	SLC35A5	solute carrier family 35, member A5	3285	0.23
chr1_28975271_28975442	0.23	ENSG00000270103	.	244	0.88
chr17_66700653_66700804	0.23	ENSG00000263690	.	61972	0.13
chr13_31309966_31310295	0.23	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	485	0.88
chr20_48913768_48913919	0.23	CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	106467	0.06
chr2_225809390_225809894	0.23	DOCK10	dedicator of cytokinesis 10	2140	0.45
chr15_50627461_50627612	0.22	GABPB1	GA binding protein transcription factor, beta subunit 1	8010	0.14
chr8_82022711_82022967	0.22	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	1464	0.56
chr6_106536140_106536635	0.22	PRDM1	PR domain containing 1, with ZNF domain	932	0.64
chr8_48648492_48649280	0.22	CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	2762	0.26
chr1_226251298_226251924	0.22	H3F3A	H3 histone, family 3A	67	0.97
chr21_39645775_39646073	0.22	KCNJ15	potassium inwardly-rectifying channel, subfamily J, member 15	1495	0.53
chr14_31879526_31879677	0.22	HEATR5A	HEAT repeat containing 5A	7420	0.17
chr3_59696011_59696162	0.22	NPCDR1	nasopharyngeal carcinoma, down-regulated 1	261497	0.02
chrX_40437074_40437225	0.22	ATP6AP2	ATPase, H+ transporting, lysosomal accessory protein 2	2997	0.29
chr14_52339978_52340129	0.22	GNG2	guanine nucleotide binding protein (G protein), gamma 2	4257	0.24
chr6_114178016_114178613	0.22	MARCKS	myristoylated alanine-rich protein kinase C substrate	227	0.93
chr7_50348449_50348781	0.22	IKZF1	IKAROS family zinc finger 1 (Ikaros)	297	0.94
chr19_46088302_46088477	0.22	OPA3	optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)	289	0.84
chr20_56194431_56194643	0.22	ZBP1	Z-DNA binding protein 1	913	0.65
chr4_2486639_2486842	0.22	RNF4	ring finger protein 4	4798	0.2
chr12_65108828_65108979	0.22	AC025262.1	Mesenchymal stem cell protein DSC96; Uncharacterized protein	18574	0.13
chr1_208047081_208047232	0.22	CD34	CD34 molecule	16681	0.25
chr3_69129681_69129838	0.22	UBA3	ubiquitin-like modifier activating enzyme 3	200	0.92
chr19_54465805_54465956	0.22	CACNG8	calcium channel, voltage-dependent, gamma subunit 8	414	0.72
chr17_81147907_81148162	0.22	METRNL	meteorin, glial cell differentiation regulator-like	96040	0.08
chr8_9005081_9005340	0.22	PPP1R3B	protein phosphatase 1, regulatory subunit 3B	2996	0.21
chr7_150149402_150149565	0.22	GIMAP8	GTPase, IMAP family member 8	1765	0.33
chr1_158983210_158983361	0.22	IFI16	interferon, gamma-inducible protein 16	1186	0.5
chr18_74837172_74837323	0.22	MBP	myelin basic protein	2421	0.42
chr11_61792453_61792604	0.22	AP003733.1	Uncharacterized protein; cDNA FLJ36460 fis, clone THYMU2014801	57075	0.08
chr6_42532119_42532973	0.22	UBR2	ubiquitin protein ligase E3 component n-recognin 2	746	0.71
chr5_118606012_118606179	0.22	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	1646	0.37
chr1_150584633_150584820	0.22	ENSG00000253047	.	11591	0.1
chr17_8859778_8859929	0.22	PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	9171	0.24
chr3_12228694_12228845	0.22	TIMP4	TIMP metallopeptidase inhibitor 4	27918	0.22
chr4_141015619_141015856	0.22	RP11-392B6.1		33432	0.2
chr1_95561573_95561724	0.21	TMEM56	transmembrane protein 56	21246	0.11
chr5_126147731_126147991	0.21	LMNB1	lamin B1	34980	0.19
chr6_41528112_41529137	0.21	FOXP4	forkhead box P4	4863	0.19
chr1_11785555_11785706	0.21	AGTRAP	angiotensin II receptor-associated protein	10511	0.12
chr1_249111594_249111745	0.21	SH3BP5L	SH3-binding domain protein 5-like	397	0.81
chrX_136650028_136650459	0.21	ZIC3	Zic family member 3	1566	0.39
chrX_153190817_153191535	0.21	ARHGAP4	Rho GTPase activating protein 4	522	0.6
chr11_58989802_58989953	0.21	ENSG00000263999	.	7705	0.17
chrX_118818753_118818904	0.21	SEPT6	septin 6	7964	0.18
chr5_118606885_118607036	0.21	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	2511	0.28
chr2_65245033_65245279	0.21	AC007386.4		19475	0.14
chr14_102276711_102277223	0.21	CTD-2017C7.2		309	0.73
chr3_36937412_36937563	0.21	TRANK1	tetratricopeptide repeat and ankyrin repeat containing 1	37113	0.17
chr14_68320261_68320412	0.21	RAD51B	RAD51 paralog B	30075	0.16
chr1_111415846_111416285	0.21	CD53	CD53 molecule	289	0.91
chrX_1600809_1601304	0.21	ASMTL	acetylserotonin O-methyltransferase-like	28401	0.16
chr8_133770966_133771357	0.21	TMEM71	transmembrane protein 71	1633	0.38
chr7_37488846_37488997	0.21	ELMO1	engulfment and cell motility 1	69	0.98
chr3_108543496_108543820	0.21	TRAT1	T cell receptor associated transmembrane adaptor 1	2039	0.42
chr3_128710945_128711096	0.21	KIAA1257	KIAA1257	280	0.88
chr5_176326174_176326325	0.21	HK3	hexokinase 3 (white cell)	84	0.98
chr19_42249623_42249774	0.21	CEACAM6	carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)	5187	0.14
chr9_129235089_129235240	0.21	ENSG00000252985	.	45992	0.13
chrX_53711459_53711652	0.21	HUWE1	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	441	0.89
chr8_126447584_126447735	0.21	TRIB1	tribbles pseudokinase 1	1871	0.39
chr12_116723741_116723892	0.21	MED13L	mediator complex subunit 13-like	8673	0.24
chr3_10334877_10335066	0.21	GHRL	ghrelin/obestatin prepropeptide	340	0.8
chr8_82022969_82023806	0.20	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	916	0.72
chr19_50062782_50062933	0.20	NOSIP	nitric oxide synthase interacting protein	1030	0.27
chr19_7268349_7268500	0.20	INSR	insulin receptor	25518	0.17
chr6_24934739_24934890	0.20	FAM65B	family with sequence similarity 65, member B	1374	0.5
chr13_24146066_24146217	0.20	TNFRSF19	tumor necrosis factor receptor superfamily, member 19	1338	0.59
chr1_100852790_100852941	0.20	ENSG00000216067	.	8534	0.21
chr6_107154119_107154270	0.20	ENSG00000202285	.	32735	0.17
chr12_8666250_8666401	0.20	CLEC4D	C-type lectin domain family 4, member D	189	0.93

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of EN1_ESX1_GBX1

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0002538	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.1	0.4	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.1	0.4	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.1	0.3	GO:0030210	heparin biosynthetic process(GO:0030210)
0.1	0.3	GO:0010447	response to acidic pH(GO:0010447)
0.1	0.5	GO:0001878	response to yeast(GO:0001878)
0.1	0.4	GO:0050857	positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.1	0.4	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.1	0.2	GO:0045588	regulation of gamma-delta T cell differentiation(GO:0045586) positive regulation of gamma-delta T cell differentiation(GO:0045588)
0.1	0.3	GO:0051541	elastin metabolic process(GO:0051541)
0.1	0.5	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.1	0.2	GO:0042494	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.1	0.3	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1	0.3	GO:0042989	sequestering of actin monomers(GO:0042989)
0.1	0.2	GO:0051138	NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.1	0.2	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.1	0.3	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.1	0.5	GO:0015671	oxygen transport(GO:0015671)
0.1	0.3	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.1	0.3	GO:0055064	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.1	0.2	GO:0042663	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.1	0.5	GO:0050858	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1	0.4	GO:0045116	protein neddylation(GO:0045116)
0.1	0.2	GO:0031664	regulation of lipopolysaccharide-mediated signaling pathway(GO:0031664)
0.1	0.1	GO:0006065	UDP-glucuronate biosynthetic process(GO:0006065)
0.1	0.3	GO:0002002	regulation of angiotensin levels in blood(GO:0002002)
0.1	0.2	GO:0045056	transcytosis(GO:0045056)
0.1	0.2	GO:0006667	sphinganine metabolic process(GO:0006667)
0.1	0.4	GO:0006198	cAMP catabolic process(GO:0006198)
0.1	0.2	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.1	0.1	GO:0042661	regulation of mesodermal cell fate specification(GO:0042661) regulation of mesoderm development(GO:2000380)
0.1	0.2	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.1	GO:0052556	positive regulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052555) positive regulation by symbiont of host immune response(GO:0052556)
0.0	0.0	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0	0.1	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.6	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.1	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.2	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.4	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.1	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.2	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.3	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.1	GO:0002407	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0	0.2	GO:0044380	protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0	0.0	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.0	0.2	GO:0030910	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0	0.2	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.2	GO:0032811	negative regulation of epinephrine secretion(GO:0032811)
0.0	0.2	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.1	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.0	GO:2000542	negative regulation of gastrulation(GO:2000542)
0.0	0.2	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.2	GO:0045357	interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.0	0.2	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.1	GO:0014874	response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.0	0.1	GO:0033262	regulation of nuclear cell cycle DNA replication(GO:0033262)
0.0	0.2	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.3	GO:0045652	regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.0	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:0032695	negative regulation of interleukin-12 production(GO:0032695)
0.0	0.4	GO:0033363	secretory granule organization(GO:0033363)
0.0	0.1	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.0	0.1	GO:0051569	regulation of histone H3-K4 methylation(GO:0051569)
0.0	0.1	GO:0034616	response to laminar fluid shear stress(GO:0034616)
0.0	0.3	GO:0030889	negative regulation of B cell proliferation(GO:0030889)
0.0	0.4	GO:0019059	obsolete initiation of viral infection(GO:0019059)
0.0	0.2	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.0	0.2	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
0.0	0.1	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.1	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.0	0.1	GO:0048251	elastic fiber assembly(GO:0048251)
0.0	0.1	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.2	GO:0007406	negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0	0.2	GO:0002068	glandular epithelial cell development(GO:0002068)
0.0	0.2	GO:1901503	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.1	GO:0015825	L-serine transport(GO:0015825)
0.0	0.1	GO:0030187	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.1	GO:1904035	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0	0.1	GO:0021529	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0	0.2	GO:0045746	negative regulation of Notch signaling pathway(GO:0045746)
0.0	0.3	GO:0045648	positive regulation of erythrocyte differentiation(GO:0045648)
0.0	0.2	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.2	GO:0010324	phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0	0.2	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.1	GO:0090116	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.2	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.1	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.1	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.0	0.1	GO:0003161	cardiac conduction system development(GO:0003161)
0.0	0.1	GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0	0.1	GO:0010870	positive regulation of receptor biosynthetic process(GO:0010870)
0.0	0.1	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.1	GO:0060632	regulation of microtubule-based movement(GO:0060632)
0.0	0.2	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.1	GO:0048643	positive regulation of skeletal muscle tissue development(GO:0048643)
0.0	0.1	GO:0050765	negative regulation of phagocytosis(GO:0050765)
0.0	0.1	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0	0.1	GO:0043312	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0	0.1	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0032717	negative regulation of interleukin-8 production(GO:0032717)
0.0	0.0	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.1	GO:0045715	regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045714) negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.1	GO:0042159	lipoprotein catabolic process(GO:0042159)
0.0	0.1	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0	0.1	GO:0019372	lipoxygenase pathway(GO:0019372)
0.0	0.0	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.1	GO:1903521	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.1	GO:0048539	bone marrow development(GO:0048539)
0.0	0.1	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.0	GO:0002902	regulation of B cell apoptotic process(GO:0002902) negative regulation of B cell apoptotic process(GO:0002903)
0.0	0.1	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0	0.1	GO:0021683	cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.2	GO:0007141	male meiosis I(GO:0007141)
0.0	0.1	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.2	GO:0000085	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.0	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.3	GO:0045730	respiratory burst(GO:0045730)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.0	GO:0045713	low-density lipoprotein particle receptor biosynthetic process(GO:0045713)
0.0	0.1	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.1	GO:0070071	proton-transporting two-sector ATPase complex assembly(GO:0070071)
0.0	0.2	GO:0051568	histone H3-K4 methylation(GO:0051568)
0.0	0.1	GO:0009173	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0	0.3	GO:0006891	intra-Golgi vesicle-mediated transport(GO:0006891)
0.0	0.0	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.0	0.1	GO:0070561	vitamin D receptor signaling pathway(GO:0070561)
0.0	0.0	GO:0032803	regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) regulation of receptor catabolic process(GO:2000644)
0.0	0.0	GO:0046885	regulation of hormone biosynthetic process(GO:0046885)
0.0	0.1	GO:0036230	granulocyte activation(GO:0036230)
0.0	0.1	GO:0032148	activation of protein kinase B activity(GO:0032148)
0.0	0.1	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.2	GO:0006554	lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0	0.1	GO:0034374	low-density lipoprotein particle remodeling(GO:0034374)
0.0	0.1	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.1	GO:0043570	maintenance of DNA repeat elements(GO:0043570)
0.0	0.1	GO:0010665	striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0	0.1	GO:0001787	natural killer cell proliferation(GO:0001787)
0.0	0.5	GO:0042147	retrograde transport, endosome to Golgi(GO:0042147)
0.0	0.1	GO:0045601	regulation of endothelial cell differentiation(GO:0045601)
0.0	0.0	GO:0060340	positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.0	0.1	GO:0006878	cellular copper ion homeostasis(GO:0006878)
0.0	0.1	GO:0046825	regulation of protein export from nucleus(GO:0046825)
0.0	0.0	GO:0052251	modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553)
0.0	0.1	GO:0016265	obsolete death(GO:0016265)
0.0	0.1	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	1.2	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.1	GO:0006303	double-strand break repair via nonhomologous end joining(GO:0006303)
0.0	0.1	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.4	GO:0016574	histone ubiquitination(GO:0016574)
0.0	0.1	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0	0.1	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.0	0.1	GO:0040009	regulation of growth rate(GO:0040009)
0.0	0.4	GO:0051156	glucose 6-phosphate metabolic process(GO:0051156)
0.0	0.1	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.1	GO:0006513	protein monoubiquitination(GO:0006513)
0.0	0.0	GO:0031573	intra-S DNA damage checkpoint(GO:0031573)
0.0	0.1	GO:0015886	heme transport(GO:0015886)
0.0	0.1	GO:0033160	positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0	0.1	GO:0045351	type I interferon biosynthetic process(GO:0045351)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0033235	positive regulation of protein sumoylation(GO:0033235)
0.0	0.1	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.3	GO:0046834	lipid phosphorylation(GO:0046834)
0.0	0.1	GO:0006895	Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0	0.1	GO:0048752	semicircular canal morphogenesis(GO:0048752)
0.0	0.1	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.1	GO:0046473	phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0	0.1	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.1	GO:0000281	mitotic cytokinesis(GO:0000281)
0.0	0.1	GO:0060997	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.1	GO:0032667	interleukin-23 production(GO:0032627) regulation of interleukin-23 production(GO:0032667) positive regulation of interleukin-23 production(GO:0032747)
0.0	0.1	GO:0019060	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.1	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578) carnitine biosynthetic process(GO:0045329)
0.0	0.1	GO:0090200	positive regulation of mitochondrion organization(GO:0010822) positive regulation of release of cytochrome c from mitochondria(GO:0090200) positive regulation of apoptotic signaling pathway(GO:2001235)
0.0	0.0	GO:0060972	left/right pattern formation(GO:0060972)
0.0	0.1	GO:0006072	glycerol-3-phosphate metabolic process(GO:0006072)
0.0	0.1	GO:0048668	collateral sprouting(GO:0048668) regulation of collateral sprouting(GO:0048670)
0.0	0.1	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.0	0.1	GO:0008228	opsonization(GO:0008228)
0.0	0.0	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.0	GO:0001779	natural killer cell differentiation(GO:0001779)
0.0	0.0	GO:0032922	circadian regulation of gene expression(GO:0032922)
0.0	0.0	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.1	GO:0043388	positive regulation of DNA binding(GO:0043388)
0.0	0.0	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0	0.0	GO:0010886	positive regulation of cholesterol storage(GO:0010886)
0.0	0.0	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.2	GO:0071044	histone mRNA catabolic process(GO:0071044)
0.0	0.1	GO:0009249	protein lipoylation(GO:0009249)
0.0	0.3	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.0	GO:0034123	positive regulation of toll-like receptor signaling pathway(GO:0034123)
0.0	0.1	GO:0015781	pyrimidine nucleotide-sugar transport(GO:0015781)
0.0	0.1	GO:0051927	obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051927)
0.0	0.3	GO:0006336	DNA replication-independent nucleosome assembly(GO:0006336) CENP-A containing nucleosome assembly(GO:0034080) DNA replication-independent nucleosome organization(GO:0034724) CENP-A containing chromatin organization(GO:0061641)
0.0	0.1	GO:0033194	response to hydroperoxide(GO:0033194)
0.0	0.1	GO:0019673	GDP-mannose metabolic process(GO:0019673)
0.0	0.0	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.3	GO:0051225	spindle assembly(GO:0051225)
0.0	0.1	GO:0032615	interleukin-12 production(GO:0032615)
0.0	0.0	GO:1904358	positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0	0.0	GO:0034447	very-low-density lipoprotein particle clearance(GO:0034447)
0.0	0.0	GO:0051290	protein heterotetramerization(GO:0051290)
0.0	0.0	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.1	GO:0032401	establishment of melanosome localization(GO:0032401)
0.0	0.2	GO:0016254	preassembly of GPI anchor in ER membrane(GO:0016254)
0.0	0.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.0	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.0	GO:0042976	activation of Janus kinase activity(GO:0042976)
0.0	0.1	GO:0060123	regulation of growth hormone secretion(GO:0060123)
0.0	0.0	GO:0007000	nucleolus organization(GO:0007000)
0.0	0.1	GO:0016584	nucleosome positioning(GO:0016584)
0.0	0.0	GO:0032494	response to peptidoglycan(GO:0032494)
0.0	0.1	GO:0035024	negative regulation of Rho protein signal transduction(GO:0035024)
0.0	0.1	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
0.0	0.0	GO:0034244	negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0	0.1	GO:0045022	early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.0	GO:0008298	intracellular mRNA localization(GO:0008298)
0.0	0.2	GO:0045806	negative regulation of endocytosis(GO:0045806)
0.0	0.1	GO:0032092	positive regulation of protein binding(GO:0032092)
0.0	0.1	GO:0030838	positive regulation of actin filament polymerization(GO:0030838)
0.0	0.0	GO:0002507	tolerance induction(GO:0002507)
0.0	0.0	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.1	GO:0045123	cellular extravasation(GO:0045123)
0.0	0.1	GO:0014002	astrocyte development(GO:0014002)
0.0	0.0	GO:0060081	membrane hyperpolarization(GO:0060081)
0.0	0.1	GO:0046427	positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894)
0.0	0.0	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.0	GO:0032347	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0	0.0	GO:0015801	aromatic amino acid transport(GO:0015801)
0.0	0.1	GO:0031646	positive regulation of neurological system process(GO:0031646)
0.0	0.0	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.3	GO:0043928	nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0	0.1	GO:0050775	positive regulation of dendrite morphogenesis(GO:0050775)
0.0	0.0	GO:0010745	negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.0	0.1	GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein(GO:0042517)
0.0	0.1	GO:0008653	lipopolysaccharide metabolic process(GO:0008653)
0.0	0.0	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.0	GO:0072531	pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0	0.2	GO:0033003	regulation of mast cell activation(GO:0033003)
0.0	0.2	GO:0016578	histone deubiquitination(GO:0016578)
0.0	0.1	GO:0040001	establishment of mitotic spindle localization(GO:0040001)
0.0	0.0	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0	0.0	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.0	GO:0009120	deoxyribonucleoside metabolic process(GO:0009120)
0.0	0.0	GO:0032897	negative regulation of viral transcription(GO:0032897)
0.0	0.1	GO:0097191	extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) extrinsic apoptotic signaling pathway(GO:0097191)
0.0	0.1	GO:0002544	chronic inflammatory response(GO:0002544)
0.0	0.0	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.1	GO:0019885	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.1	GO:0070584	mitochondrion morphogenesis(GO:0070584)
0.0	0.4	GO:0070646	protein modification by small protein removal(GO:0070646)
0.0	0.1	GO:0043248	proteasome assembly(GO:0043248)
0.0	0.0	GO:0010613	positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.0	0.0	GO:0032693	negative regulation of interleukin-10 production(GO:0032693) interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.1	GO:0051001	negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0	0.1	GO:0007035	vacuolar acidification(GO:0007035)
0.0	0.1	GO:0032703	negative regulation of interleukin-2 production(GO:0032703)
0.0	0.0	GO:0045576	mast cell activation(GO:0045576)
0.0	0.2	GO:0006085	acetyl-CoA biosynthetic process(GO:0006085)
0.0	0.1	GO:0043968	histone H2A acetylation(GO:0043968)
0.0	0.0	GO:0031297	replication fork processing(GO:0031297)
0.0	0.0	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.1	GO:0045947	negative regulation of translational initiation(GO:0045947)
0.0	0.0	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.0	0.1	GO:0007168	receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0	0.1	GO:0010738	regulation of protein kinase A signaling(GO:0010738)
0.0	0.3	GO:0046320	regulation of fatty acid oxidation(GO:0046320)
0.0	0.0	GO:0045347	negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0	0.0	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.1	GO:1903963	arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.0	0.1	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.0	0.0	GO:0032814	regulation of natural killer cell activation(GO:0032814)
0.0	0.0	GO:0035583	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.0	GO:0034625	fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0	0.0	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.4	GO:0019319	hexose biosynthetic process(GO:0019319)
0.0	0.0	GO:0048867	stem cell fate commitment(GO:0048865) stem cell fate determination(GO:0048867)
0.0	0.0	GO:0002478	antigen processing and presentation of exogenous peptide antigen(GO:0002478)
0.0	0.0	GO:0046931	pore complex assembly(GO:0046931)
0.0	0.2	GO:0006071	glycerol metabolic process(GO:0006071)
0.0	0.0	GO:0030202	heparin metabolic process(GO:0030202)
0.0	0.0	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.0	GO:0031427	response to methotrexate(GO:0031427)
0.0	0.0	GO:0002532	production of molecular mediator involved in inflammatory response(GO:0002532)
0.0	0.1	GO:0006376	mRNA splice site selection(GO:0006376)
0.0	0.1	GO:0006744	ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744)
0.0	0.1	GO:0006030	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.0	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.5	GO:1902400	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) signal transduction involved in cell cycle checkpoint(GO:0072395) signal transduction involved in DNA integrity checkpoint(GO:0072401) signal transduction involved in mitotic cell cycle checkpoint(GO:0072413) signal transduction involved in DNA damage checkpoint(GO:0072422) signal transduction involved in mitotic G1 DNA damage checkpoint(GO:0072431) intracellular signal transduction involved in G1 DNA damage checkpoint(GO:1902400) signal transduction involved in mitotic DNA damage checkpoint(GO:1902402) signal transduction involved in mitotic DNA integrity checkpoint(GO:1902403)
0.0	0.7	GO:0006334	nucleosome assembly(GO:0006334)
0.0	0.1	GO:0034311	diol metabolic process(GO:0034311)
0.0	0.1	GO:0016973	poly(A)+ mRNA export from nucleus(GO:0016973)
0.0	0.0	GO:0046477	glycosylceramide catabolic process(GO:0046477)
0.0	0.2	GO:0007098	centrosome cycle(GO:0007098)
0.0	0.0	GO:0002890	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.0	GO:1903392	negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)
0.0	0.0	GO:0051968	positive regulation of synaptic transmission, glutamatergic(GO:0051968)
0.0	0.0	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.0	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.1	GO:0032508	DNA duplex unwinding(GO:0032508)
0.0	0.0	GO:0002328	pro-B cell differentiation(GO:0002328)
0.0	0.2	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0	0.8	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0	0.0	GO:0051547	regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0	0.0	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.1	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0	0.1	GO:0009148	GTP biosynthetic process(GO:0006183) UTP biosynthetic process(GO:0006228) CTP biosynthetic process(GO:0006241) pyrimidine nucleoside triphosphate biosynthetic process(GO:0009148) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036) UTP metabolic process(GO:0046051) pyrimidine ribonucleoside biosynthetic process(GO:0046132)
0.0	0.0	GO:0016093	polyprenol metabolic process(GO:0016093) dolichol metabolic process(GO:0019348)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.1	0.3	GO:0042629	mast cell granule(GO:0042629)
0.1	0.4	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.1	0.2	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.1	0.3	GO:0042405	nuclear inclusion body(GO:0042405)
0.1	0.2	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	0.2	GO:0072487	MSL complex(GO:0072487)
0.1	0.3	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.3	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.2	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.2	GO:0001739	sex chromatin(GO:0001739)
0.0	0.1	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.1	GO:0030904	retromer complex(GO:0030904)
0.0	0.1	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.2	GO:0000791	euchromatin(GO:0000791)
0.0	0.4	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0070820	tertiary granule(GO:0070820)
0.0	0.1	GO:0005639	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.2	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.3	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.1	GO:0001740	Barr body(GO:0001740)
0.0	0.4	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0	0.1	GO:0031211	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.6	GO:0030140	trans-Golgi network transport vesicle(GO:0030140)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.2	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0	0.1	GO:0097425	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0	0.0	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.2	GO:0034451	centriolar satellite(GO:0034451)
0.0	0.1	GO:0030312	external encapsulating structure(GO:0030312)
0.0	0.2	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	0.2	GO:0098984	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	0.1	GO:0032009	early phagosome(GO:0032009)
0.0	0.2	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.2	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.4	GO:0043073	germ cell nucleus(GO:0043073)
0.0	0.2	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	0.7	GO:0005626	obsolete insoluble fraction(GO:0005626)
0.0	0.1	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.1	GO:0005638	lamin filament(GO:0005638)
0.0	0.2	GO:0031010	ISWI-type complex(GO:0031010)
0.0	0.1	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.0	0.1	GO:0030992	intraciliary transport particle B(GO:0030992)
0.0	0.1	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0	0.2	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.0	0.0	GO:0070852	cell body fiber(GO:0070852)
0.0	0.1	GO:0000125	PCAF complex(GO:0000125)
0.0	0.3	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.9	GO:0016605	PML body(GO:0016605)
0.0	0.2	GO:0000421	autophagosome membrane(GO:0000421)
0.0	0.1	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.0	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.2	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.1	GO:0071203	WASH complex(GO:0071203)
0.0	1.7	GO:0016607	nuclear speck(GO:0016607)
0.0	0.0	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.8	GO:0000786	nucleosome(GO:0000786)
0.0	0.1	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.0	0.2	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0	0.1	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.0	0.0	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.1	GO:0045335	phagocytic vesicle(GO:0045335)
0.0	0.1	GO:0070531	BRCA1-A complex(GO:0070531)
0.0	0.1	GO:0070776	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.1	GO:0000153	cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0	0.1	GO:0032590	dendrite membrane(GO:0032590)
0.0	0.0	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.1	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.1	GO:0060198	clathrin-sculpted vesicle(GO:0060198)
0.0	0.9	GO:0031985	Golgi cisterna(GO:0031985)
0.0	0.2	GO:0030137	COPI-coated vesicle(GO:0030137)
0.0	0.1	GO:0001772	immunological synapse(GO:0001772)
0.0	0.1	GO:0016580	Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822)
0.0	0.6	GO:0031901	early endosome membrane(GO:0031901)
0.0	0.0	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.0	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.0	0.2	GO:0030532	small nuclear ribonucleoprotein complex(GO:0030532)
0.0	0.0	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.2	GO:0005689	U12-type spliceosomal complex(GO:0005689)
0.0	0.0	GO:0000347	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0	0.1	GO:0070652	HAUS complex(GO:0070652)
0.0	0.3	GO:0005902	microvillus(GO:0005902)
0.0	0.1	GO:0031143	pseudopodium(GO:0031143)
0.0	0.0	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.1	GO:0034464	BBSome(GO:0034464)
0.0	0.0	GO:0031933	telomeric heterochromatin(GO:0031933)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0050544	arachidonic acid binding(GO:0050544)
0.1	0.3	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1	0.5	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1	0.2	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.1	0.4	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.1	0.3	GO:0001846	opsonin binding(GO:0001846)
0.1	0.4	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.1	0.2	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.1	0.2	GO:0042289	MHC class II protein binding(GO:0042289)
0.1	0.2	GO:0004340	glucokinase activity(GO:0004340)
0.1	0.2	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.1	0.2	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1	0.2	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.1	0.1	GO:1901567	icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.1	0.2	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	0.4	GO:0001784	phosphotyrosine binding(GO:0001784)
0.1	0.2	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.2	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.2	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.3	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.2	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.1	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.2	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.2	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.5	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.1	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.1	GO:0004307	ethanolaminephosphotransferase activity(GO:0004307)
0.0	0.1	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.1	GO:0004738	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.2	GO:0016531	copper chaperone activity(GO:0016531)
0.0	0.1	GO:0016886	ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0	0.1	GO:0004875	complement receptor activity(GO:0004875)
0.0	0.1	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.1	GO:0015194	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.3	GO:0030276	clathrin binding(GO:0030276)
0.0	0.1	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.1	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.1	GO:0004525	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0	0.2	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.5	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.1	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.1	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.2	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.0	0.2	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.1	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.1	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.3	GO:0008641	small protein activating enzyme activity(GO:0008641)
0.0	0.2	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.3	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.1	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0	0.1	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.1	GO:0097493	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.2	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0	0.2	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.2	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
0.0	0.1	GO:0032357	single guanine insertion binding(GO:0032142) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357)
0.0	0.2	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.1	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.2	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.5	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.1	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.1	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.1	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.1	GO:0045159	myosin II binding(GO:0045159)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.3	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.2	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.1	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.2	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.0	0.1	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.4	GO:0048487	beta-tubulin binding(GO:0048487)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0015923	mannosidase activity(GO:0015923)
0.0	1.0	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.5	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.0	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.1	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.2	GO:0004383	guanylate cyclase activity(GO:0004383)
0.0	0.0	GO:0004396	hexokinase activity(GO:0004396)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
0.0	0.1	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.0	0.4	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0042285	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.2	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.0	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.1	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.1	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.1	GO:0015232	heme transporter activity(GO:0015232)
0.0	0.1	GO:0004550	nucleoside diphosphate kinase activity(GO:0004550)
0.0	0.3	GO:0042162	telomeric DNA binding(GO:0042162)
0.0	0.1	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.4	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0045118	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.1	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.7	GO:0003678	DNA helicase activity(GO:0003678)
0.0	0.1	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.1	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.3	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.1	GO:0031491	nucleosome binding(GO:0031491)
0.0	0.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.1	GO:0030507	spectrin binding(GO:0030507)
0.0	0.2	GO:0019894	kinesin binding(GO:0019894)
0.0	0.0	GO:0051425	PTB domain binding(GO:0051425)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.3	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.0	GO:0043175	RNA polymerase core enzyme binding(GO:0043175)
0.0	0.2	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.4	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.0	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0019789	SUMO transferase activity(GO:0019789)
0.0	0.0	GO:0070569	uridylyltransferase activity(GO:0070569)
0.0	0.1	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.0	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.0	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0030332	cyclin binding(GO:0030332)
0.0	0.0	GO:0008192	RNA guanylyltransferase activity(GO:0008192)
0.0	0.1	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.0	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.1	GO:0005338	nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.0	GO:0035197	siRNA binding(GO:0035197)
0.0	0.1	GO:0015385	sodium:proton antiporter activity(GO:0015385)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.3	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0019864	IgG binding(GO:0019864)
0.0	0.3	GO:0017022	myosin binding(GO:0017022)
0.0	0.0	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.2	GO:0008186	RNA-dependent ATPase activity(GO:0008186)
0.0	0.1	GO:0048365	Rac GTPase binding(GO:0048365)
0.0	0.0	GO:0046625	sphingolipid binding(GO:0046625)
0.0	0.1	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.0	GO:0004802	transketolase activity(GO:0004802)
0.0	0.0	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.0	GO:0035198	miRNA binding(GO:0035198)
0.0	0.1	GO:0016417	S-acyltransferase activity(GO:0016417)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.1	GO:0017069	snRNA binding(GO:0017069)
0.0	0.1	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.0	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.1	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.0	GO:0032450	maltose alpha-glucosidase activity(GO:0032450)
0.0	0.0	GO:0036137	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.1	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.2	GO:0042809	vitamin D receptor binding(GO:0042809)
0.0	0.0	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.1	GO:0051721	protein phosphatase 2A binding(GO:0051721)
0.0	0.1	GO:0004950	G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0	0.1	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.1	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.1	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.0	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.4	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.0	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.0	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.0	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.1	GO:0034185	apolipoprotein binding(GO:0034185)
0.0	0.0	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.1	GO:0016854	racemase and epimerase activity(GO:0016854)
0.0	0.1	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.0	GO:0070492	oligosaccharide binding(GO:0070492)
0.0	0.0	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.3	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.0	GO:0032138	single base insertion or deletion binding(GO:0032138)
0.0	0.1	GO:0005355	glucose transmembrane transporter activity(GO:0005355)
0.0	0.1	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.1	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	0.1	GO:0070628	proteasome binding(GO:0070628)
0.0	0.1	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.2	GO:0000030	mannosyltransferase activity(GO:0000030)
0.0	0.0	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0	0.1	GO:0015520	tetracycline:proton antiporter activity(GO:0015520)
0.0	0.0	GO:0032137	guanine/thymine mispair binding(GO:0032137)
0.0	0.7	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	0.2	GO:0003995	acyl-CoA dehydrogenase activity(GO:0003995)
0.0	0.0	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.1	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.0	GO:0004339	glucan 1,4-alpha-glucosidase activity(GO:0004339)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.0	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0	0.0	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
0.0	0.0	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.1	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.1	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0046966	thyroid hormone receptor binding(GO:0046966)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	0.8	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	0.9	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	0.6	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	0.9	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	1.4	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.0	0.8	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	0.3	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	0.3	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	0.6	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.0	0.1	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.0	1.0	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.1	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.2	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	0.3	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	0.6	PID IFNG PATHWAY	IFN-gamma pathway
0.0	0.1	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	0.0	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.1	PID ARF6 PATHWAY	Arf6 signaling events
0.0	0.2	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.3	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	0.5	PID BCR 5PATHWAY	BCR signaling pathway
0.0	0.1	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.0	0.2	PID IL3 PATHWAY	IL3-mediated signaling events
0.0	0.1	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.0	0.1	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	0.4	PID RHOA PATHWAY	RhoA signaling pathway
0.0	0.2	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.0	0.2	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	0.2	PID S1P S1P3 PATHWAY	S1P3 pathway
0.0	0.3	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	0.2	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	0.6	PID FANCONI PATHWAY	Fanconi anemia pathway
0.0	0.1	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	0.1	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	0.2	PID TRAIL PATHWAY	TRAIL signaling pathway
0.0	0.1	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	0.2	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.0	0.2	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.0	0.1	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0	0.1	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	0.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	0.1	PID EPO PATHWAY	EPO signaling pathway
0.0	0.1	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.0	0.2	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	0.1	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0	0.1	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.0	0.0	PID FAS PATHWAY	FAS (CD95) signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.1	0.8	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	0.7	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	0.1	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	1.4	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.0	0.1	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0	0.0	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0	0.4	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.0	0.7	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.9	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	0.5	REACTOME CD28 CO STIMULATION	Genes involved in CD28 co-stimulation
0.0	0.3	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.0	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.0	0.1	REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	Genes involved in NGF signalling via TRKA from the plasma membrane
0.0	0.1	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.4	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.4	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	0.3	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.0	0.1	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.2	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	0.0	REACTOME SIGNALING BY FGFR IN DISEASE	Genes involved in Signaling by FGFR in disease
0.0	0.3	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.0	0.3	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.4	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.0	0.2	REACTOME TCR SIGNALING	Genes involved in TCR signaling
0.0	0.1	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.1	REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0	0.4	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	0.2	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.0	REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0	0.2	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.4	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	1.2	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.4	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.1	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.4	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.1	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.0	0.4	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	0.0	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	0.0	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
0.0	0.3	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.6	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	0.2	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	0.3	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0	0.1	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	0.2	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0	0.2	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.0	0.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.5	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0	0.2	REACTOME PIP3 ACTIVATES AKT SIGNALING	Genes involved in PIP3 activates AKT signaling
0.0	0.2	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.0	1.5	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	0.1	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.1	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.0	0.0	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.3	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.1	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0	0.1	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.0	0.0	REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0	0.3	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	0.2	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.0	0.0	REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	Genes involved in Nuclear Events (kinase and transcription factor activation)
0.0	0.1	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.2	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.1	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
0.0	0.1	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.2	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.0	0.2	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.2	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0	0.0	REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	Genes involved in Interactions of Vpr with host cellular proteins
0.0	0.1	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.2	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.0	0.1	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.0	0.4	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0	0.1	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.0	0.3	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0	0.3	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.5	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.0	0.1	REACTOME BIOLOGICAL OXIDATIONS	Genes involved in Biological oxidations
0.0	0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.1	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0	0.0	REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE	Genes involved in p53-Dependent G1 DNA Damage Response
0.0	0.1	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	0.7	REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0	0.1	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.0	0.2	REACTOME MRNA SPLICING MINOR PATHWAY	Genes involved in mRNA Splicing - Minor Pathway
0.0	0.0	REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0	0.0	REACTOME DOUBLE STRAND BREAK REPAIR	Genes involved in Double-Strand Break Repair
0.0	0.6	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	0.1	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.0	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation
0.0	0.4	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.0	0.2	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0	0.1	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.1	REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING	Genes involved in Activation of Kainate Receptors upon glutamate binding
0.0	0.1	REACTOME HOST INTERACTIONS OF HIV FACTORS	Genes involved in Host Interactions of HIV factors
0.0	0.1	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0	0.2	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0	0.3	REACTOME TOLL RECEPTOR CASCADES	Genes involved in Toll Receptor Cascades
0.0	0.2	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.0	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.2	REACTOME METABOLISM OF NON CODING RNA	Genes involved in Metabolism of non-coding RNA
0.0	0.1	REACTOME RNA POL I TRANSCRIPTION INITIATION	Genes involved in RNA Polymerase I Transcription Initiation
0.0	0.3	REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	Genes involved in Transport of Mature Transcript to Cytoplasm
0.0	0.1	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription

Results for EN1_ESX1_GBX1

Z-value: 0.63

Motif logo

Transcription factors associated with EN1_ESX1_GBX1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the EN1_ESX1_GBX1 motif across conditions

Conditions sorted by the z-value of the EN1_ESX1_GBX1 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of EN1_ESX1_GBX1

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: