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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for EN2_GBX2_LBX2

Z-value: 0.30

Motif logo

Transcription factors associated with EN2_GBX2_LBX2

Gene Symbol	Gene ID	Gene Info
EN2 Ensembl NCBI GeneCards UniProt	ENSG00000164778.4	EN2
GBX2 Ensembl NCBI GeneCards UniProt	ENSG00000168505.6	GBX2
LBX2 Ensembl NCBI GeneCards UniProt	ENSG00000179528.11	LBX2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
EN2	chr7_155259792_155259943	9043	0.196903	0.48	1.9e-01	Click!
EN2	chr7_155260838_155261005	10097	0.193888	0.39	3.0e-01	Click!
EN2	chr7_155250668_155250957	12	0.979457	-0.31	4.1e-01	Click!
EN2	chr7_155265207_155265358	14458	0.183389	-0.28	4.6e-01	Click!
EN2	chr7_155261127_155261495	10487	0.192858	0.28	4.7e-01	Click!
GBX2	chr2_237076524_237076816	18	0.912238	0.48	1.9e-01	Click!
GBX2	chr2_237081096_237081247	4159	0.174508	0.44	2.4e-01	Click!
GBX2	chr2_237077720_237077871	783	0.524265	-0.35	3.6e-01	Click!
GBX2	chr2_237080254_237080405	3317	0.189489	-0.34	3.7e-01	Click!
GBX2	chr2_237088721_237088872	11784	0.144978	0.31	4.1e-01	Click!
LBX2	chr2_74730587_74730945	323	0.619077	0.61	8.1e-02	Click!
LBX2	chr2_74729754_74730571	51	0.816052	0.44	2.3e-01	Click!
LBX2	chr2_74726789_74726940	21	0.808069	0.41	2.7e-01	Click!
LBX2	chr2_74732376_74732527	2008	0.103893	0.40	2.9e-01	Click!
LBX2	chr2_74731433_74731584	1065	0.203023	0.10	8.0e-01	Click!

Activity of the EN2_GBX2_LBX2 motif across conditions

Conditions sorted by the z-value of the EN2_GBX2_LBX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_94661378_94661529	0.07	RP11-856F16.2		2767	0.3
chr10_116584415_116584656	0.07	FAM160B1	family with sequence similarity 160, member B1	3006	0.37
chr4_144312492_144312643	0.06	GAB1	GRB2-associated binding protein 1	96	0.98
chr6_681837_682046	0.06	EXOC2	exocyst complex component 2	11170	0.25
chr13_45242068_45242279	0.06	ENSG00000238932	.	39364	0.2
chr13_97875674_97876020	0.06	MBNL2	muscleblind-like splicing regulator 2	1238	0.62
chr1_28834546_28835031	0.06	ENSG00000200087	.	283	0.74
chr5_102897969_102898137	0.06	NUDT12	nudix (nucleoside diphosphate linked moiety X)-type motif 12	437	0.91
chr14_103058041_103058305	0.05	RCOR1	REST corepressor 1	825	0.6
chr4_109532705_109532935	0.05	RPL34	ribosomal protein L34	8902	0.2
chr13_96295623_96295774	0.05	DZIP1	DAZ interacting zinc finger protein 1	181	0.96
chr10_91461400_91461679	0.05	KIF20B	kinesin family member 20B	103	0.98
chr3_79067433_79067887	0.05	ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)	34	0.99
chr14_76604893_76605206	0.05	GPATCH2L	G patch domain containing 2-like	13213	0.26
chr3_112356169_112356393	0.05	CCDC80	coiled-coil domain containing 80	663	0.77
chr5_134370433_134370584	0.05	PITX1	paired-like homeodomain 1	5	0.97
chr5_77822199_77822489	0.05	LHFPL2	lipoma HMGIC fusion partner-like 2	22630	0.27
chr1_238027813_238027997	0.05	RP11-193H5.1		2430	0.36
chr11_27406666_27406921	0.05	CCDC34	coiled-coil domain containing 34	21378	0.22
chr10_105211471_105211777	0.05	CALHM2	calcium homeostasis modulator 2	451	0.57
chr9_133711223_133711921	0.05	ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	1119	0.56
chr15_50648671_50648965	0.05	ENSG00000244879	.	150	0.91
chr11_61158553_61158704	0.05	TMEM216	transmembrane protein 216	531	0.65
chr11_65324098_65324348	0.05	LTBP3	latent transforming growth factor beta binding protein 3	1013	0.31
chr1_115258427_115259019	0.05	NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog	792	0.54
chr19_2962281_2962480	0.05	TLE6	transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)	15064	0.12
chr1_16677722_16678052	0.05	FBXO42	F-box protein 42	1062	0.47
chr10_70230757_70231440	0.05	DNA2	DNA replication helicase/nuclease 2	545	0.71
chr7_6654683_6655004	0.05	ZNF853	zinc finger protein 853	405	0.77
chr5_125758847_125759062	0.05	GRAMD3	GRAM domain containing 3	85	0.98
chr7_18535021_18535832	0.04	HDAC9	histone deacetylase 9	47	0.99
chr1_196577911_196578299	0.04	KCNT2	potassium channel, subfamily T, member 2	250	0.94
chr8_87188438_87188625	0.04	CTD-3118D11.3		4116	0.24
chr5_178956771_178956922	0.04	RUFY1	RUN and FYVE domain containing 1	20713	0.17
chr1_101359723_101359874	0.04	EXTL2	exostosin-like glycosyltransferase 2	422	0.6
chr1_245461989_245462162	0.04	RP11-62I21.1		64272	0.12
chr6_16486388_16486539	0.04	ENSG00000265642	.	57709	0.16
chr3_159483781_159484285	0.04	IQCJ-SCHIP1	IQCJ-SCHIP1 readthrough	1141	0.44
chr11_12716213_12716424	0.04	TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	19268	0.26
chr1_177953163_177953341	0.04	SEC16B	SEC16 homolog B (S. cerevisiae)	13904	0.3
chr18_67822225_67822376	0.04	RTTN	rotatin	50662	0.17
chr9_136215868_136216170	0.04	ENSG00000206611	.	232	0.42
chr6_52440366_52440800	0.04	TRAM2	translocation associated membrane protein 2	1130	0.59
chr12_116008040_116008436	0.04	ENSG00000240205	.	147292	0.05
chr4_89522534_89522685	0.04	HERC3	HECT and RLD domain containing E3 ubiquitin protein ligase 3	4336	0.21
chr2_101620301_101620452	0.04	RPL31	ribosomal protein L31	1175	0.38
chr16_77619617_77619768	0.04	ENSG00000221226	.	124506	0.05
chr1_88150357_88150552	0.04	ENSG00000199318	.	231398	0.02
chr6_53928552_53928746	0.04	MLIP-AS1	MLIP antisense RNA 1	15875	0.2
chr17_37007920_37008364	0.04	ENSG00000252699	.	230	0.78
chr18_2573280_2573731	0.04	NDC80	NDC80 kinetochore complex component	1941	0.23
chr6_26313507_26313734	0.04	HIST1H4H	histone cluster 1, H4h	27858	0.07
chr3_87038506_87038677	0.04	VGLL3	vestigial like 3 (Drosophila)	1261	0.64
chr6_119027020_119027704	0.04	CEP85L	centrosomal protein 85kDa-like	3869	0.35
chr2_85831784_85832049	0.04	TMEM150A	transmembrane protein 150A	2095	0.16
chr2_224808584_224808735	0.04	WDFY1	WD repeat and FYVE domain containing 1	1415	0.42
chr11_68924666_68924817	0.04	RP11-554A11.9		1363	0.5
chr4_146467351_146467609	0.04	SMAD1-AS1	SMAD1 antisense RNA 1	29210	0.17
chr8_22023419_22024083	0.04	BMP1	bone morphogenetic protein 1	951	0.4
chr15_57516945_57517146	0.04	TCF12	transcription factor 12	5381	0.29
chr2_675828_676052	0.04	TMEM18	transmembrane protein 18	165	0.93
chr4_153511797_153511976	0.04	ENSG00000268471	.	54306	0.12
chr3_156469026_156469297	0.04	TIPARP	TCDD-inducible poly(ADP-ribose) polymerase	70206	0.1
chr18_19612717_19612880	0.03	ENSG00000265568	.	33268	0.15
chr10_116474996_116475239	0.03	ABLIM1	actin binding LIM protein 1	30703	0.21
chr12_66220556_66220804	0.03	HMGA2	high mobility group AT-hook 2	1777	0.39
chr2_197832046_197832264	0.03	ANKRD44	ankyrin repeat domain 44	33071	0.18
chr15_96878465_96878729	0.03	ENSG00000222651	.	2107	0.24
chr1_8087615_8088020	0.03	ERRFI1	ERBB receptor feedback inhibitor 1	1449	0.45
chr5_14039928_14040178	0.03	DNAH5	dynein, axonemal, heavy chain 5	95401	0.09
chr4_152337049_152337200	0.03	FAM160A1	family with sequence similarity 160, member A1	6620	0.28
chr16_24742200_24742688	0.03	TNRC6A	trinucleotide repeat containing 6A	1410	0.55
chr2_217235630_217236249	0.03	MARCH4	membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase	811	0.59
chr3_16024121_16024347	0.03	ENSG00000207815	.	108956	0.06
chr12_133347795_133347946	0.03	ANKLE2	ankyrin repeat and LEM domain containing 2	9396	0.15
chr15_101261674_101262051	0.03	ENSG00000212306	.	83294	0.08
chr10_52750817_52751095	0.03	PRKG1	protein kinase, cGMP-dependent, type I	11	0.99
chr12_54120032_54120198	0.03	CALCOCO1	calcium binding and coiled-coil domain 1	9	0.98
chr22_46476561_46476775	0.03	FLJ27365	hsa-mir-4763	476	0.66
chr8_110619590_110619741	0.03	SYBU	syntabulin (syntaxin-interacting)	639	0.72
chr11_16759613_16759958	0.03	C11orf58	chromosome 11 open reading frame 58	163	0.97
chr17_47547430_47548013	0.03	NGFR	nerve growth factor receptor	24934	0.13
chr2_189158529_189158680	0.03	GULP1	GULP, engulfment adaptor PTB domain containing 1	59	0.98
chr18_11852846_11853378	0.03	RP11-78A19.3		362	0.77
chr10_27129753_27129904	0.03	ABI1	abl-interactor 1	19964	0.17
chr19_49121111_49121642	0.03	RPL18	ribosomal protein L18	235	0.79
chr1_214723042_214723197	0.03	PTPN14	protein tyrosine phosphatase, non-receptor type 14	1447	0.54
chr11_20179312_20179463	0.03	DBX1	developing brain homeobox 1	2483	0.35
chr1_205342500_205342651	0.03	LEMD1-AS1	LEMD1 antisense RNA 1	195	0.93
chrX_118612161_118612324	0.03	SLC25A5	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5	9879	0.14
chr6_149256843_149257025	0.03	RP11-162J8.2		28886	0.23
chr7_26141990_26142141	0.03	ENSG00000266430	.	42106	0.14
chr13_107160462_107160937	0.03	EFNB2	ephrin-B2	26763	0.24
chr14_80678419_80678624	0.03	DIO2	deiodinase, iodothyronine, type II	0	0.95
chr14_29859562_29859789	0.03	ENSG00000257522	.	11813	0.29
chr22_25388088_25388316	0.03	KIAA1671	KIAA1671	35739	0.16
chr10_53126976_53127127	0.03	RP11-539E19.2		64725	0.12
chr6_3390423_3390626	0.03	SLC22A23	solute carrier family 22, member 23	49128	0.15
chr9_112748695_112748951	0.03	AKAP2	A kinase (PRKA) anchor protein 2	62055	0.14
chr2_188418561_188419245	0.03	AC007319.1		27	0.69
chr7_107640774_107640963	0.03	ENSG00000238297	.	441	0.76
chr6_49794571_49794884	0.03	RP3-417L20.4		9584	0.19
chr16_67513595_67513746	0.03	ATP6V0D1	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1	1312	0.23
chr9_13278507_13279169	0.03	RP11-272P10.2		348	0.67
chr6_85896028_85896266	0.03	NT5E	5'-nucleotidase, ecto (CD73)	263662	0.02
chr1_225610206_225610357	0.03	LBR	lamin B receptor	5318	0.2
chr8_145562079_145562230	0.03	SCRT1	scratch family zinc finger 1	2211	0.12
chr12_112845942_112846255	0.03	RPL6	ribosomal protein L6	658	0.71
chr10_102921756_102921944	0.03	RP11-31L23.3		22382	0.12
chr19_35158241_35158444	0.03	SCGB2B2	secretoglobin, family 2B, member 2	8262	0.14
chr6_37665761_37665951	0.03	MDGA1	MAM domain containing glycosylphosphatidylinositol anchor 1	90	0.98
chr4_47916858_47917055	0.03	NFXL1	nuclear transcription factor, X-box binding-like 1	323	0.9
chr18_65188257_65188408	0.03	DSEL	dermatan sulfate epimerase-like	4115	0.29
chr1_89992055_89992206	0.03	LRRC8B	leucine rich repeat containing 8 family, member B	1668	0.45
chr2_55458779_55458930	0.03	RPS27A	ribosomal protein S27a	185	0.75
chr1_212607133_212607429	0.03	NENF	neudesin neurotrophic factor	1052	0.52
chr15_59064816_59065008	0.03	FAM63B	family with sequence similarity 63, member B	1351	0.36
chr20_52749591_52749788	0.03	CYP24A1	cytochrome P450, family 24, subfamily A, polypeptide 1	38803	0.16
chr17_40574158_40574426	0.03	PTRF	polymerase I and transcript release factor	1243	0.31
chr21_46629242_46629401	0.03	ADARB1	adenosine deaminase, RNA-specific, B1	37764	0.14
chr16_85202371_85202571	0.03	CTC-786C10.1		2411	0.35
chr3_45732221_45732372	0.03	SACM1L	SAC1 suppressor of actin mutations 1-like (yeast)	1345	0.36
chr7_93634348_93634499	0.03	BET1	Bet1 golgi vesicular membrane trafficking protein	729	0.72
chr8_145134632_145134783	0.03	EXOSC4	exosome component 4	381	0.5
chr9_122131014_122131286	0.03	BRINP1	bone morphogenetic protein/retinoic acid inducible neural-specific 1	553	0.87
chr5_39074216_39074429	0.03	RICTOR	RPTOR independent companion of MTOR, complex 2	169	0.97
chr6_155428404_155428796	0.03	TIAM2	T-cell lymphoma invasion and metastasis 2	14450	0.28
chr1_221914094_221914536	0.03	DUSP10	dual specificity phosphatase 10	1146	0.66
chr1_153918448_153918692	0.03	DENND4B	DENN/MADD domain containing 4B	602	0.54
chr4_81198150_81198317	0.03	FGF5	fibroblast growth factor 5	10440	0.25
chr11_131780111_131780399	0.03	NTM	neurotrimin	642	0.77
chr15_50410621_50410772	0.03	ATP8B4	ATPase, class I, type 8B, member 4	723	0.73
chr8_131271894_131272045	0.03	ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	12681	0.28
chr17_79010696_79011070	0.03	BAIAP2	BAI1-associated protein 2	1080	0.4
chr12_106812256_106812407	0.03	POLR3B	polymerase (RNA) III (DNA directed) polypeptide B	36581	0.19
chr2_157197921_157198176	0.03	NR4A2	nuclear receptor subfamily 4, group A, member 2	812	0.72
chr4_170580994_170582031	0.03	CLCN3	chloride channel, voltage-sensitive 3	299	0.93
chr10_6763782_6764322	0.03	PRKCQ	protein kinase C, theta	141789	0.05
chr1_109236074_109236443	0.03	PRPF38B	pre-mRNA processing factor 38B	1295	0.4
chr12_131796680_131796831	0.03	ENSG00000212251	.	12459	0.23
chr17_18091438_18091835	0.03	RP11-258F1.1		3569	0.14
chr5_88129391_88129549	0.03	MEF2C	myocyte enhancer factor 2C	6495	0.28
chr8_94507892_94508285	0.03	ENSG00000222416	.	54583	0.14
chr10_76971114_76971464	0.03	VDAC2	voltage-dependent anion channel 2	75	0.97
chr17_37774592_37774840	0.03	PPP1R1B	protein phosphatase 1, regulatory (inhibitor) subunit 1B	8277	0.12
chr3_81474618_81474769	0.03	ENSG00000222389	.	83934	0.11
chr4_186732947_186733362	0.03	SORBS2	sorbin and SH3 domain containing 2	21	0.99
chr10_5853342_5853785	0.03	GDI2	GDP dissociation inhibitor 2	1787	0.37
chr11_12791215_12791367	0.03	TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	24703	0.2
chr10_106007564_106007715	0.03	GSTO1	glutathione S-transferase omega 1	6313	0.13
chr15_96870341_96870527	0.03	NR2F2-AS1	NR2F2 antisense RNA 1	89	0.95
chr12_49763265_49763746	0.03	SPATS2	spermatogenesis associated, serine-rich 2	2175	0.22
chr6_31804565_31804904	0.02	C6orf48	chromosome 6 open reading frame 48	114	0.47
chr8_145561472_145561771	0.02	SCRT1	scratch family zinc finger 1	1678	0.16
chr3_111584178_111584329	0.02	PHLDB2	pleckstrin homology-like domain, family B, member 2	5610	0.29
chr20_53950546_53950697	0.02	ENSG00000252089	.	474270	0.01
chr7_116313737_116313903	0.02	MET	met proto-oncogene	1361	0.53
chr14_50098662_50099178	0.02	RP11-649E7.7		2312	0.13
chr5_71310437_71310588	0.02	MAP1B	microtubule-associated protein 1B	92549	0.09
chr18_3305605_3305756	0.02	MYL12B	myosin, light chain 12B, regulatory	42726	0.12
chr17_60954301_60954474	0.02	ENSG00000207552	.	67189	0.11
chr8_1113646_1113943	0.02	ERICH1-AS1	ERICH1 antisense RNA 1	280466	0.01
chr6_27463328_27463580	0.02	ZNF184	zinc finger protein 184	22557	0.21
chr1_234613311_234613591	0.02	TARBP1	TAR (HIV-1) RNA binding protein 1	1398	0.49
chr12_54120989_54121200	0.02	CALCOCO1	calcium binding and coiled-coil domain 1	118	0.96
chr9_72635619_72635770	0.02	MAMDC2	MAM domain containing 2	22803	0.23
chr13_38172411_38172686	0.02	POSTN	periostin, osteoblast specific factor	315	0.95
chr17_55655751_55655910	0.02	RP11-118E18.4		29943	0.16
chr12_66221036_66221187	0.02	HMGA2	high mobility group AT-hook 2	2208	0.34
chr16_87552092_87552315	0.02	ZCCHC14	zinc finger, CCHC domain containing 14	26552	0.17
chr13_109639795_109639946	0.02	MYO16	myosin XVI	101353	0.08
chr3_156893095_156894129	0.02	ENSG00000243176	.	476	0.72
chr2_227050440_227050625	0.02	ENSG00000263363	.	472977	0.01
chr12_27399648_27399799	0.02	STK38L	serine/threonine kinase 38 like	1133	0.61
chr5_107041117_107041487	0.02	ENSG00000239708	.	29465	0.21
chr6_42192493_42192832	0.02	MRPS10	mitochondrial ribosomal protein S10	7059	0.19
chr3_194293558_194293709	0.02	TMEM44-AS1	TMEM44 antisense RNA 1	11107	0.15
chr1_160368401_160368552	0.02	VANGL2	VANGL planar cell polarity protein 2	1900	0.24
chr15_60212309_60212460	0.02	FOXB1	forkhead box B1	84037	0.1
chrX_83325612_83325763	0.02	RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	117228	0.07
chr8_8745763_8746197	0.02	MFHAS1	malignant fibrous histiocytoma amplified sequence 1	5175	0.22
chr1_107682797_107683388	0.02	NTNG1	netrin G1	350	0.93
chr9_139780499_139780693	0.02	TRAF2	TNF receptor-associated factor 2	79	0.86
chr7_151123543_151123787	0.02	RP4-555L14.4		1104	0.36
chr12_122984366_122984751	0.02	ZCCHC8	zinc finger, CCHC domain containing 8	237	0.91
chr2_200335677_200335876	0.02	SATB2	SATB homeobox 2	213	0.91
chr2_190014978_190015129	0.02	ENSG00000264725	.	17216	0.2
chr11_34938171_34938707	0.02	PDHX	pyruvate dehydrogenase complex, component X	251	0.64
chr11_72019545_72019702	0.02	CLPB	ClpB caseinolytic peptidase B homolog (E. coli)	5	0.97
chr10_50969933_50970461	0.02	OGDHL	oxoglutarate dehydrogenase-like	172	0.97
chr2_66663569_66663965	0.02	MEIS1	Meis homeobox 1	758	0.57
chrX_73833546_73833857	0.02	RLIM	ring finger protein, LIM domain interacting	751	0.74
chr16_2654273_2654460	0.02	AC141586.5		891	0.35
chr19_45459212_45459543	0.02	CLPTM1	cleft lip and palate associated transmembrane protein 1	562	0.53
chr8_41649611_41650018	0.02	ANK1	ankyrin 1, erythrocytic	5326	0.2
chr16_86603613_86603777	0.02	RP11-463O9.5		2328	0.23
chr3_150479775_150480371	0.02	SIAH2-AS1	SIAH2 antisense RNA 1	349	0.79
chr3_196282059_196282210	0.02	WDR53	WD repeat domain 53	12047	0.13
chr7_116141667_116142184	0.02	CAV2	caveolin 2	2091	0.24
chr1_78471558_78472034	0.02	DNAJB4	DnaJ (Hsp40) homolog, subfamily B, member 4	1258	0.34

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of EN2_GBX2_LBX2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Total log-likelihood	Term	Description
0.0	GO:0070932	histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0	GO:0021827	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.1	GO:0048625	myoblast fate commitment(GO:0048625)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.0	GO:0031932	TORC2 complex(GO:0031932)