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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ESR1

Z-value: 0.83

Motif logo

Transcription factors associated with ESR1

Gene Symbol	Gene ID	Gene Info
ESR1 Ensembl NCBI GeneCards UniProt	ENSG00000091831.17	ESR1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ESR1	chr6_152238268_152238543	36613	0.213069	0.67	4.8e-02	Click!
ESR1	chr6_152237063_152237214	35346	0.216886	0.63	6.9e-02	Click!
ESR1	chr6_152043262_152043413	31706	0.208973	-0.50	1.8e-01	Click!
ESR1	chr6_151990290_151990441	21266	0.222650	0.47	2.1e-01	Click!
ESR1	chr6_152126783_152127038	102	0.976307	0.45	2.2e-01	Click!

Activity of the ESR1 motif across conditions

Conditions sorted by the z-value of the ESR1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr8_11323568_11323719	0.36	FAM167A	family with sequence similarity 167, member A	633	0.67
chr13_114831006_114831265	0.32	RASA3	RAS p21 protein activator 3	12303	0.24
chr20_18037263_18037961	0.28	OVOL2	ovo-like zinc finger 2	909	0.48
chr3_49940788_49940939	0.27	MST1R	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	179	0.78
chr11_67078749_67078900	0.25	SSH3	slingshot protein phosphatase 3	3696	0.13
chr1_153587674_153587825	0.25	S100A14	S100 calcium binding protein A14	665	0.44
chr22_46482810_46483184	0.25	FLJ27365	hsa-mir-4763	1114	0.31
chr7_45002030_45002849	0.25	RP4-647J21.1		1931	0.25
chr14_105435453_105435767	0.25	AHNAK2	AHNAK nucleoprotein 2	9084	0.16
chr9_110249313_110249729	0.24	KLF4	Kruppel-like factor 4 (gut)	1890	0.38
chr8_10086913_10087064	0.24	MSRA	methionine sulfoxide reductase A	72057	0.11
chr8_142289533_142290316	0.24	RP11-10J21.3	Uncharacterized protein	25260	0.12
chr20_62168477_62168628	0.24	PTK6	protein tyrosine kinase 6	143	0.91
chr9_140708937_140709088	0.23	ENSG00000207693	.	23859	0.19
chr19_39227082_39227399	0.23	CAPN12	calpain 12	1178	0.28
chr5_1931344_1931629	0.23	CTD-2194D22.4		44040	0.13
chr14_24630498_24631577	0.22	IRF9	interferon regulatory factor 9	527	0.47
chr14_91882732_91883366	0.22	CCDC88C	coiled-coil domain containing 88C	641	0.78
chr19_41882652_41883217	0.22	TMEM91	transmembrane protein 91	60	0.74
chr10_13143957_13144489	0.22	OPTN	optineurin	1998	0.3
chr5_1315874_1316496	0.22	ENSG00000263670	.	6693	0.18
chr22_20008729_20009650	0.22	TANGO2	transport and golgi organization 2 homolog (Drosophila)	511	0.64
chr18_47089345_47089666	0.22	LIPG	lipase, endothelial	790	0.6
chr1_36809017_36809168	0.22	STK40	serine/threonine kinase 40	17849	0.12
chr1_6531968_6532119	0.22	TNFRSF25	tumor necrosis factor receptor superfamily, member 25	5788	0.12
chr19_51455517_51455668	0.21	KLK5	kallikrein-related peptidase 5	606	0.48
chr15_101774475_101774626	0.21	CHSY1	chondroitin sulfate synthase 1	17587	0.17
chr19_8554749_8554900	0.21	HNRNPM	heterogeneous nuclear ribonucleoprotein M	3782	0.14
chr17_48601050_48601201	0.21	MYCBPAP	MYCBP associated protein	44	0.95
chr2_74668653_74669044	0.21	RTKN	rhotekin	178	0.86
chr17_74868821_74868990	0.21	MGAT5B	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B	176	0.95
chr14_100046170_100046321	0.21	CCDC85C	coiled-coil domain containing 85C	218	0.93
chr19_2275585_2275736	0.21	OAZ1	ornithine decarboxylase antizyme 1	5370	0.09
chr4_715290_715441	0.20	RP11-1191J2.4		2458	0.16
chr4_1796827_1797107	0.20	FGFR3	fibroblast growth factor receptor 3	1344	0.42
chr20_61733088_61733940	0.20	ENSG00000225978	.	31	0.98
chr20_39970036_39970187	0.20	LPIN3	lipin 3	551	0.77
chr17_7942417_7942568	0.20	ALOX15B	arachidonate 15-lipoxygenase, type B	18	0.95
chr2_183225036_183225187	0.20	ENSG00000242121	.	46100	0.17
chr1_3620270_3620421	0.20	TP73	tumor protein p73	5723	0.12
chr1_26680354_26680505	0.20	AIM1L	absent in melanoma 1-like	192	0.9
chr21_41095530_41095681	0.20	IGSF5	immunoglobulin superfamily, member 5	21729	0.21
chr20_43970794_43971114	0.20	SDC4	syndecan 4	6110	0.13
chr22_44568627_44569086	0.20	PARVG	parvin, gamma	20	0.99
chr1_1015485_1015798	0.20	RNF223	ring finger protein 223	5954	0.1
chr8_145012042_145012193	0.20	PLEC	plectin	1641	0.24
chr8_144820927_144821078	0.20	FAM83H	family with sequence similarity 83, member H	5031	0.09
chr22_46546744_46547896	0.19	PPARA	peroxisome proliferator-activated receptor alpha	467	0.75
chr14_54430258_54430823	0.19	BMP4	bone morphogenetic protein 4	5061	0.28
chr20_55204347_55205219	0.19	TFAP2C	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	425	0.81
chr19_54057819_54058678	0.19	ZNF331	zinc finger protein 331	167	0.9
chr3_5055440_5055591	0.19	BHLHE40-AS1	BHLHE40 antisense RNA 1	33869	0.15
chr1_156092284_156092708	0.19	LMNA	lamin A/C	3455	0.14
chr19_10406663_10406906	0.19	ICAM5	intercellular adhesion molecule 5, telencephalin	5131	0.08
chr16_70740729_70741027	0.19	VAC14	Vac14 homolog (S. cerevisiae)	6730	0.15
chr21_33247526_33247677	0.19	HUNK	hormonally up-regulated Neu-associated kinase	1973	0.45
chr19_35608806_35608957	0.18	FXYD3	FXYD domain containing ion transport regulator 3	50	0.95
chr12_67807670_67807821	0.18	CAND1	cullin-associated and neddylation-dissociated 1	114993	0.07
chr17_76967334_76967485	0.18	LGALS3BP	lectin, galactoside-binding, soluble, 3 binding protein	5996	0.16
chr18_74331565_74332218	0.18	LINC00908	long intergenic non-protein coding RNA 908	91017	0.08
chr11_66829839_66829990	0.18	RHOD	ras homolog family member D	5554	0.17
chr17_46127912_46128198	0.18	NFE2L1	nuclear factor, erythroid 2-like 1	1561	0.2
chr1_1173779_1173930	0.18	B3GALT6	UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6	6225	0.08
chr6_96455538_96455689	0.18	FUT9	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)	8247	0.33
chr11_70963000_70963203	0.18	SHANK2	SH3 and multiple ankyrin repeat domains 2	522	0.86
chr16_31146277_31146629	0.18	PRSS8	protease, serine, 8	508	0.52
chr14_35871775_35873043	0.18	NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	937	0.68
chr11_1552591_1552742	0.18	DUSP8	dual specificity phosphatase 8	34500	0.1
chr13_106939337_106939488	0.18	ENSG00000222682	.	131573	0.05
chr9_139776272_139777152	0.18	TRAF2	TNF receptor-associated factor 2	327	0.72
chr14_99710276_99710624	0.18	AL109767.1		18835	0.2
chr3_10858354_10858505	0.18	SLC6A11	solute carrier family 6 (neurotransmitter transporter), member 11	543	0.85
chr1_37943283_37943786	0.18	ZC3H12A	zinc finger CCCH-type containing 12A	3381	0.18
chr2_232537261_232537412	0.17	ENSG00000239202	.	26352	0.14
chr17_70114398_70114549	0.17	SOX9	SRY (sex determining region Y)-box 9	2688	0.41
chr2_239036083_239036322	0.17	ESPNL	espin-like	166	0.94
chr7_55253774_55253939	0.17	EGFR-AS1	EGFR antisense RNA 1	2771	0.38
chr2_241949003_241950045	0.17	AC093585.6		637	0.62
chr16_75416401_75416552	0.17	RP11-252K23.2		1318	0.36
chr19_1469984_1470717	0.17	ENSG00000267317	.	7586	0.07
chr9_134460250_134460544	0.17	RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	36828	0.13
chr2_239037206_239037357	0.17	ESPNL	espin-like	1245	0.38
chr14_55035520_55036036	0.17	SAMD4A	sterile alpha motif domain containing 4A	1141	0.56
chrX_48323916_48324124	0.17	SLC38A5	solute carrier family 38, member 5	1860	0.23
chr1_21620629_21620823	0.17	ECE1	endothelin converting enzyme 1	191	0.89
chr12_2403889_2404040	0.17	CACNA1C-IT3	CACNA1C intronic transcript 3 (non-protein coding)	25022	0.23
chr3_52491643_52491832	0.17	NISCH	nischarin	2104	0.18
chr7_1690037_1690188	0.17	ELFN1	extracellular leucine-rich repeat and fibronectin type III domain containing 1	37643	0.14
chr6_41703786_41703937	0.17	TFEB	transcription factor EB	136	0.93
chr8_144907347_144907498	0.17	PUF60	poly-U binding splicing factor 60KDa	3774	0.11
chr19_34216636_34216787	0.17	CHST8	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8	41277	0.18
chr10_125852855_125853389	0.17	CHST15	carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15	84	0.98
chr1_151579139_151579290	0.17	SNX27	sorting nexin family member 27	5344	0.12
chr6_36098764_36099262	0.17	MAPK13	mitogen-activated protein kinase 13	573	0.74
chr1_1978273_1978424	0.17	RP11-547D24.3		2742	0.18
chr1_46955506_46955688	0.17	DMBX1	diencephalon/mesencephalon homeobox 1	17071	0.16
chr4_1798938_1799089	0.17	FGFR3	fibroblast growth factor receptor 3	3390	0.22
chr20_1309605_1309756	0.17	SDCBP2	syndecan binding protein (syntenin) 2	203	0.91
chr20_39969728_39969901	0.17	LPIN3	lipin 3	254	0.92
chr18_74798828_74799607	0.16	MBP	myelin basic protein	18000	0.27
chr8_144302737_144302888	0.16	GPIHBP1	glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1	7744	0.14
chr13_24270271_24270700	0.16	AL139080.1	Uncharacterized protein	51758	0.14
chr5_2749613_2749799	0.16	IRX2	iroquois homeobox 2	2063	0.35
chr11_61657871_61658132	0.16	FADS3	fatty acid desaturase 3	852	0.49
chr1_55518873_55519024	0.16	PCSK9	proprotein convertase subtilisin/kexin type 9	13053	0.2
chr19_54369142_54369556	0.16	MYADM	myeloid-associated differentiation marker	128	0.89
chr19_13957589_13958095	0.16	ENSG00000207980	.	10369	0.08
chr18_77938309_77938600	0.16	AC139100.3		3109	0.25
chr16_85832192_85833030	0.16	COX4I1	cytochrome c oxidase subunit IV isoform 1	372	0.56
chr8_10590631_10590782	0.16	SOX7	SRY (sex determining region Y)-box 7	2684	0.21
chr1_16538998_16539149	0.16	ARHGEF19	Rho guanine nucleotide exchange factor (GEF) 19	31	0.96
chr10_35060387_35060538	0.16	PARD3	par-3 family cell polarity regulator	43787	0.16
chr8_145008502_145008738	0.16	PLEC	plectin	5138	0.12
chr11_10695962_10696877	0.16	MRVI1	murine retrovirus integration site 1 homolog	18642	0.17
chr10_73769586_73770005	0.16	CHST3	carbohydrate (chondroitin 6) sulfotransferase 3	45672	0.15
chr1_185528978_185529129	0.16	ENSG00000207108	.	70607	0.11
chr17_79378256_79378407	0.16	ENSG00000266392	.	3753	0.14
chr19_11252844_11253247	0.16	SPC24	SPC24, NDC80 kinetochore complex component	13392	0.13
chr3_133476385_133476536	0.16	TF	transferrin	11223	0.18
chr4_3043146_3044167	0.16	ENSG00000199335	.	2172	0.29
chr7_139047352_139047690	0.16	C7orf55-LUC7L2	C7orf55-LUC7L2 readthrough	2867	0.19
chr20_45946936_45948261	0.16	AL031666.2	HCG2018772; Uncharacterized protein; cDNA FLJ31609 fis, clone NT2RI2002852	352	0.82
chr2_149895781_149895992	0.16	LYPD6B	LY6/PLAUR domain containing 6B	654	0.82
chr10_29978497_29978648	0.15	ENSG00000222092	.	22272	0.21
chr19_3387681_3387832	0.15	NFIC	nuclear factor I/C (CCAAT-binding transcription factor)	21172	0.16
chr16_57653725_57653876	0.15	GPR56	G protein-coupled receptor 56	54	0.97
chr4_17783377_17783652	0.15	FAM184B	family with sequence similarity 184, member B	379	0.88
chr22_19792099_19792250	0.15	TBX1	T-box 1	47948	0.1
chr8_22423482_22424350	0.15	SORBS3	sorbin and SH3 domain containing 3	402	0.6
chr8_145698019_145698220	0.15	FOXH1	forkhead box H1	3599	0.07
chr5_58055562_58056142	0.15	RP11-479O16.1		24754	0.24
chr2_106886104_106886958	0.15	UXS1	UDP-glucuronate decarboxylase 1	75736	0.1
chr19_13961881_13962048	0.15	ENSG00000207980	.	14491	0.07
chr6_50817384_50817535	0.15	TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	31020	0.25
chr8_128919529_128920109	0.15	TMEM75	transmembrane protein 75	40772	0.15
chr22_40391518_40391669	0.15	FAM83F	family with sequence similarity 83, member F	640	0.7
chr19_940940_941628	0.15	ARID3A	AT rich interactive domain 3A (BRIGHT-like)	8775	0.08
chr6_160721267_160721418	0.15	SLC22A2	solute carrier family 22 (organic cation transporter), member 2	22672	0.23
chr11_65360517_65360668	0.15	KCNK7	potassium channel, subfamily K, member 7	380	0.52
chr1_34631906_34632332	0.15	C1orf94	chromosome 1 open reading frame 94	365	0.8
chr17_15554007_15555167	0.15	RP11-640I15.1		317	0.52
chr5_55839563_55839714	0.15	AC022431.3		5985	0.25
chr12_125002282_125002834	0.15	NCOR2	nuclear receptor corepressor 2	282	0.95
chr17_79779492_79779643	0.15	FAM195B	family with sequence similarity 195, member B	2796	0.11
chr19_4061941_4062216	0.15	CTD-2622I13.3		669	0.55
chr11_60609533_60610326	0.15	CCDC86	coiled-coil domain containing 86	385	0.51
chr16_3014465_3014677	0.15	KREMEN2	kringle containing transmembrane protein 2	49	0.93
chr1_41966637_41966788	0.15	EDN2	endothelin 2	16370	0.19
chr1_12675825_12676469	0.15	DHRS3	dehydrogenase/reductase (SDR family) member 3	1590	0.37
chr17_8218792_8218943	0.15	AC135178.7		3163	0.11
chr19_49567989_49568490	0.15	NTF4	neurotrophin 4	72	0.9
chr17_61513067_61513218	0.15	CYB561	cytochrome b561	597	0.65
chr9_103791551_103791702	0.15	LPPR1	Lipid phosphate phosphatase-related protein type 1	635	0.84
chr22_46959420_46959714	0.15	GRAMD4	GRAM domain containing 4	12342	0.19
chr19_55658159_55658310	0.15	TNNT1	troponin T type 1 (skeletal, slow)	76	0.93
chr14_105330590_105330952	0.15	CEP170B	centrosomal protein 170B	846	0.6
chr11_6341290_6341712	0.15	PRKCDBP	protein kinase C, delta binding protein	261	0.9
chr20_62573957_62574108	0.14	ENSG00000207554	.	47	0.9
chr17_7492081_7492232	0.14	SOX15	SRY (sex determining region Y)-box 15	1234	0.16
chr11_8299597_8299748	0.14	LMO1	LIM domain only 1 (rhombotin 1)	9409	0.26
chr20_39945349_39946123	0.14	ZHX3	zinc fingers and homeoboxes 3	90	0.97
chr5_150970622_150970773	0.14	FAT2	FAT atypical cadherin 2	22192	0.17
chrX_153187182_153187333	0.14	ARHGAP4	Rho GTPase activating protein 4	369	0.73
chr17_43249924_43250075	0.14	RP13-890H12.2		1048	0.34
chr1_155097548_155097699	0.14	EFNA1	ephrin-A1	2313	0.11
chr5_167243776_167243927	0.14	ENSG00000221741	.	53819	0.13
chr8_145020311_145020609	0.14	PLEC	plectin	113	0.91
chr19_3098811_3099227	0.14	GNA11	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	4611	0.13
chr14_105564128_105564279	0.14	GPR132	G protein-coupled receptor 132	32421	0.14
chr19_1749690_1749939	0.14	ONECUT3	one cut homeobox 3	2558	0.2
chrX_11782921_11783072	0.14	MSL3	male-specific lethal 3 homolog (Drosophila)	5249	0.33
chr6_12288567_12288718	0.14	EDN1	endothelin 1	1954	0.48
chr17_79316804_79317024	0.14	TMEM105	transmembrane protein 105	12440	0.13
chr1_156785806_156786457	0.14	SH2D2A	SH2 domain containing 2A	495	0.51
chr13_114186665_114186816	0.14	TMCO3	transmembrane and coiled-coil domains 3	41382	0.11
chr1_153507238_153508458	0.14	S100A6	S100 calcium binding protein A6	619	0.48
chr1_6479504_6479655	0.14	HES2	hes family bHLH transcription factor 2	384	0.76
chr11_1410043_1410900	0.14	BRSK2	BR serine/threonine kinase 2	658	0.72
chr16_89427901_89428186	0.14	ANKRD11	ankyrin repeat domain 11	32649	0.1
chr16_68824059_68824234	0.14	RP11-354M1.2		33283	0.12
chr4_1761839_1761990	0.14	TACC3	transforming, acidic coiled-coil containing protein 3	31783	0.12
chr1_230223344_230223516	0.14	GALNT2	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	20412	0.23
chr2_120041666_120041961	0.14	STEAP3-AS1	STEAP3 antisense RNA 1	35166	0.15
chr11_567710_568184	0.14	ENSG00000199038	.	251	0.8
chr19_42440673_42440856	0.14	ARHGEF1	Rho guanine nucleotide exchange factor (GEF) 1	13518	0.12
chr10_99331899_99332050	0.14	ANKRD2	ankyrin repeat domain 2 (stretch responsive muscle)	224	0.89
chr8_142083960_142084111	0.14	DENND3	DENN/MADD domain containing 3	43342	0.14
chr17_78866297_78866787	0.14	RPTOR	regulatory associated protein of MTOR, complex 1	29982	0.14
chr19_13110560_13110829	0.14	NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	4042	0.11
chr11_3876946_3878257	0.14	STIM1	stromal interaction molecule 1	189	0.59
chr15_31757911_31758062	0.14	KLF13	Kruppel-like factor 13	99629	0.08
chr17_7256192_7256343	0.14	KCTD11	potassium channel tetramerization domain containing 11	1059	0.2
chr6_108141455_108142294	0.14	SCML4	sex comb on midleg-like 4 (Drosophila)	3642	0.33
chr7_73021530_73021732	0.14	MLXIPL	MLX interacting protein-like	8860	0.14
chr2_128395783_128395934	0.14	LIMS2	LIM and senescent cell antigen-like domains 2	3848	0.17
chr17_38656484_38656635	0.14	TNS4	tensin 4	1290	0.42
chr1_38513049_38513583	0.14	POU3F1	POU class 3 homeobox 1	866	0.54
chr9_131126990_131127303	0.14	URM1	ubiquitin related modifier 1	6452	0.1
chr10_8076986_8077137	0.14	GATA3	GATA binding protein 3	19595	0.29
chr13_30168298_30169638	0.14	SLC7A1	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	857	0.74

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ESR1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0010511	regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.1	0.3	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.1	0.1	GO:0060594	mammary gland specification(GO:0060594)
0.1	0.2	GO:0072217	negative regulation of metanephros development(GO:0072217)
0.1	0.2	GO:0060737	prostate gland morphogenetic growth(GO:0060737)
0.1	0.2	GO:1903579	negative regulation of nucleoside metabolic process(GO:0045978) negative regulation of ATP metabolic process(GO:1903579)
0.1	0.7	GO:0031581	hemidesmosome assembly(GO:0031581)
0.1	0.2	GO:0032808	lacrimal gland development(GO:0032808)
0.1	0.3	GO:0003100	regulation of systemic arterial blood pressure by endothelin(GO:0003100)
0.1	0.2	GO:0045617	negative regulation of keratinocyte differentiation(GO:0045617)
0.1	0.2	GO:0048859	formation of anatomical boundary(GO:0048859)
0.1	0.1	GO:0045605	negative regulation of epidermal cell differentiation(GO:0045605) regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.1	0.2	GO:0033145	positive regulation of intracellular steroid hormone receptor signaling pathway(GO:0033145)
0.1	0.1	GO:0032236	obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.1	0.2	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.1	0.2	GO:0070141	response to UV-A(GO:0070141)
0.1	0.2	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.1	0.2	GO:0003323	type B pancreatic cell development(GO:0003323)
0.1	0.2	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.1	GO:0010980	regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.1	GO:0021978	telencephalon regionalization(GO:0021978)
0.0	0.1	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
0.0	0.0	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0	0.2	GO:0070977	organ maturation(GO:0048799) bone maturation(GO:0070977)
0.0	0.2	GO:0072070	loop of Henle development(GO:0072070)
0.0	0.0	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.0	0.2	GO:0060120	auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.0	0.3	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0	0.1	GO:0001705	ectoderm formation(GO:0001705)
0.0	0.1	GO:0002693	positive regulation of cellular extravasation(GO:0002693)
0.0	0.4	GO:0042135	neurotransmitter catabolic process(GO:0042135)
0.0	0.0	GO:0034201	response to oleic acid(GO:0034201)
0.0	0.1	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.0	0.1	GO:0010159	specification of organ position(GO:0010159)
0.0	0.1	GO:0042268	regulation of cytolysis(GO:0042268)
0.0	0.1	GO:0021898	commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0	0.2	GO:0090025	regulation of monocyte chemotaxis(GO:0090025) positive regulation of monocyte chemotaxis(GO:0090026)
0.0	0.0	GO:0010533	regulation of activation of Janus kinase activity(GO:0010533) positive regulation of activation of Janus kinase activity(GO:0010536)
0.0	0.1	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.2	GO:0010765	positive regulation of sodium ion transport(GO:0010765)
0.0	0.1	GO:0043276	anoikis(GO:0043276)
0.0	0.1	GO:0016115	diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0	0.1	GO:0019511	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0	0.1	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.1	GO:0060462	lung lobe development(GO:0060462) lung lobe morphogenesis(GO:0060463)
0.0	0.2	GO:0007494	midgut development(GO:0007494)
0.0	0.1	GO:0051590	positive regulation of neurotransmitter transport(GO:0051590)
0.0	0.2	GO:0002281	macrophage activation involved in immune response(GO:0002281)
0.0	0.1	GO:0030859	polarized epithelial cell differentiation(GO:0030859) establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0	0.1	GO:0032230	positive regulation of synaptic transmission, GABAergic(GO:0032230)
0.0	0.1	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.1	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.0	GO:0060585	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0	0.0	GO:0050765	negative regulation of phagocytosis(GO:0050765)
0.0	0.1	GO:0060539	diaphragm development(GO:0060539)
0.0	0.0	GO:0048570	notochord morphogenesis(GO:0048570)
0.0	0.1	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.1	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.1	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367)
0.0	0.1	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.1	GO:0008049	male courtship behavior(GO:0008049)
0.0	0.1	GO:0035609	C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0	0.1	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0	0.1	GO:0061339	establishment of apical/basal cell polarity(GO:0035089) establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
0.0	0.0	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.1	GO:0010614	negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0	0.1	GO:0002019	regulation of renal output by angiotensin(GO:0002019)
0.0	0.1	GO:0021834	chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834)
0.0	0.2	GO:0033137	negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0	0.1	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.0	GO:0034625	fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0	0.1	GO:0051608	histamine transport(GO:0051608)
0.0	0.2	GO:0060317	cardiac epithelial to mesenchymal transition(GO:0060317)
0.0	0.0	GO:1903960	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0	0.0	GO:0061072	iris morphogenesis(GO:0061072)
0.0	0.1	GO:0050917	sensory perception of umami taste(GO:0050917)
0.0	0.1	GO:0007144	female meiosis I(GO:0007144)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.2	GO:0048841	regulation of axon extension involved in axon guidance(GO:0048841)
0.0	0.1	GO:0034122	negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.0	0.1	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.1	GO:0032957	inositol trisphosphate metabolic process(GO:0032957)
0.0	0.0	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.1	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.0	GO:0031943	regulation of glucocorticoid metabolic process(GO:0031943)
0.0	0.2	GO:0047497	establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0	0.1	GO:0061043	vascular wound healing(GO:0061042) regulation of vascular wound healing(GO:0061043)
0.0	0.0	GO:0048714	positive regulation of oligodendrocyte differentiation(GO:0048714)
0.0	0.1	GO:0008089	anterograde axonal transport(GO:0008089)
0.0	0.1	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.1	GO:0070857	regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.0	0.1	GO:0001839	neural plate morphogenesis(GO:0001839) neural plate development(GO:0001840)
0.0	0.1	GO:0045416	positive regulation of interleukin-8 biosynthetic process(GO:0045416)
0.0	0.1	GO:0015742	alpha-ketoglutarate transport(GO:0015742)
0.0	0.1	GO:0061029	eyelid development in camera-type eye(GO:0061029)
0.0	0.1	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.1	GO:0003215	cardiac right ventricle morphogenesis(GO:0003215)
0.0	0.1	GO:0014721	voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0	0.0	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.2	GO:0051445	regulation of meiotic cell cycle(GO:0051445)
0.0	0.1	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.1	GO:0042167	porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0	0.1	GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.0	0.0	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.2	GO:0009437	amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.0	0.1	GO:0044413	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.0	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0	0.0	GO:0014874	response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.0	0.1	GO:0071542	dopaminergic neuron differentiation(GO:0071542)
0.0	0.2	GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein(GO:0042523)
0.0	0.2	GO:0032461	positive regulation of protein oligomerization(GO:0032461)
0.0	0.1	GO:0061384	heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0	0.0	GO:0090273	regulation of somatostatin secretion(GO:0090273)
0.0	0.1	GO:0071501	response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0	0.1	GO:0036037	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.1	GO:0090281	negative regulation of calcium ion import(GO:0090281) negative regulation of cation transmembrane transport(GO:1904063)
0.0	0.1	GO:0060014	granulosa cell differentiation(GO:0060014)
0.0	0.1	GO:0006111	regulation of gluconeogenesis(GO:0006111)
0.0	0.1	GO:0032331	negative regulation of chondrocyte differentiation(GO:0032331)
0.0	0.1	GO:0000042	protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0	0.1	GO:0051546	keratinocyte migration(GO:0051546)
0.0	0.1	GO:0018119	protein nitrosylation(GO:0017014) peptidyl-cysteine S-nitrosylation(GO:0018119)
0.0	0.2	GO:0035329	hippo signaling(GO:0035329)
0.0	0.0	GO:0014820	tonic smooth muscle contraction(GO:0014820) artery smooth muscle contraction(GO:0014824)
0.0	0.1	GO:0042415	norepinephrine metabolic process(GO:0042415)
0.0	0.1	GO:0006533	aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.0	0.2	GO:0010984	regulation of lipoprotein particle clearance(GO:0010984)
0.0	0.0	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0	0.0	GO:0042637	catagen(GO:0042637)
0.0	0.1	GO:2000272	negative regulation of receptor activity(GO:2000272)
0.0	0.1	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.0	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.0	0.1	GO:0033197	response to vitamin E(GO:0033197)
0.0	0.0	GO:0071425	hematopoietic stem cell proliferation(GO:0071425)
0.0	0.1	GO:0032610	interleukin-1 alpha production(GO:0032610)
0.0	0.0	GO:0010592	positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0	0.1	GO:0090494	dopamine uptake involved in synaptic transmission(GO:0051583) catecholamine uptake involved in synaptic transmission(GO:0051934) catecholamine uptake(GO:0090493) dopamine uptake(GO:0090494)
0.0	0.1	GO:0021520	spinal cord motor neuron cell fate specification(GO:0021520)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.1	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0010830	regulation of myotube differentiation(GO:0010830)
0.0	0.1	GO:0007635	chemosensory behavior(GO:0007635)
0.0	0.0	GO:0072179	nephric duct formation(GO:0072179)
0.0	0.1	GO:0045351	type I interferon biosynthetic process(GO:0045351)
0.0	0.1	GO:1903672	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0060897	neural plate anterior/posterior regionalization(GO:0021999) neural plate regionalization(GO:0060897)
0.0	0.1	GO:0030917	midbrain-hindbrain boundary development(GO:0030917)
0.0	0.1	GO:0007216	G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0	0.0	GO:0048289	isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.1	GO:0043097	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0	0.0	GO:0048664	neuron fate determination(GO:0048664)
0.0	0.0	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.0	GO:0055026	negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0	0.0	GO:0010755	regulation of plasminogen activation(GO:0010755)
0.0	0.1	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.0	GO:0001774	microglial cell activation(GO:0001774)
0.0	0.0	GO:0070295	renal water absorption(GO:0070295)
0.0	0.1	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.0	GO:0032060	bleb assembly(GO:0032060)
0.0	0.0	GO:0034204	lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0	0.0	GO:0006007	glucose catabolic process(GO:0006007)
0.0	0.0	GO:0060413	atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0	0.1	GO:1901862	negative regulation of striated muscle tissue development(GO:0045843) negative regulation of muscle tissue development(GO:1901862)
0.0	0.0	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.0	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.0	GO:0046958	nonassociative learning(GO:0046958)
0.0	0.1	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.1	GO:0042136	neurotransmitter biosynthetic process(GO:0042136)
0.0	0.1	GO:0060438	trachea development(GO:0060438)
0.0	0.0	GO:0015820	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0	0.0	GO:0071503	response to heparin(GO:0071503) cellular response to heparin(GO:0071504)
0.0	0.0	GO:0010842	retina layer formation(GO:0010842)
0.0	0.1	GO:0048048	embryonic eye morphogenesis(GO:0048048)
0.0	0.0	GO:0060561	apoptotic process involved in morphogenesis(GO:0060561)
0.0	0.2	GO:0001738	morphogenesis of a polarized epithelium(GO:0001738)
0.0	0.0	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.1	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.1	GO:0060023	soft palate development(GO:0060023)
0.0	0.0	GO:0071481	cellular response to X-ray(GO:0071481)
0.0	0.0	GO:0006065	UDP-glucuronate biosynthetic process(GO:0006065)
0.0	0.1	GO:0042441	eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.0	0.0	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.1	GO:0048016	inositol phosphate-mediated signaling(GO:0048016)
0.0	0.1	GO:0031000	response to caffeine(GO:0031000)
0.0	0.0	GO:0046185	aldehyde catabolic process(GO:0046185)
0.0	0.0	GO:0006565	L-serine catabolic process(GO:0006565)
0.0	0.1	GO:0051290	protein heterotetramerization(GO:0051290)
0.0	0.0	GO:2000008	regulation of protein localization to cell surface(GO:2000008)
0.0	0.1	GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation(GO:0000394) tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0	0.0	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.0	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.1	GO:0030828	positive regulation of cGMP biosynthetic process(GO:0030828)
0.0	0.2	GO:0007190	activation of adenylate cyclase activity(GO:0007190)
0.0	0.2	GO:0030850	prostate gland development(GO:0030850)
0.0	0.0	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.0	GO:1904893	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.1	GO:0045109	intermediate filament organization(GO:0045109)
0.0	0.0	GO:0001973	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.1	GO:0043647	inositol phosphate metabolic process(GO:0043647)
0.0	0.1	GO:0042994	cytoplasmic sequestering of transcription factor(GO:0042994)
0.0	0.1	GO:0006172	ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0	0.0	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.0	GO:0051926	negative regulation of calcium ion transport(GO:0051926)
0.0	0.2	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0	0.0	GO:0042634	regulation of hair cycle(GO:0042634)
0.0	0.0	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.0	0.0	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0	0.1	GO:0051496	positive regulation of stress fiber assembly(GO:0051496)
0.0	0.0	GO:0090103	cochlea morphogenesis(GO:0090103)
0.0	0.0	GO:0002363	alpha-beta T cell lineage commitment(GO:0002363) CD4-positive or CD8-positive, alpha-beta T cell lineage commitment(GO:0043369)
0.0	0.1	GO:0035116	embryonic hindlimb morphogenesis(GO:0035116)
0.0	0.0	GO:0010543	regulation of platelet activation(GO:0010543)
0.0	0.0	GO:0000966	RNA 5'-end processing(GO:0000966)
0.0	0.0	GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.0	0.0	GO:0001977	renal system process involved in regulation of blood volume(GO:0001977)
0.0	0.0	GO:0018101	protein citrullination(GO:0018101) citrulline biosynthetic process(GO:0019240)
0.0	0.0	GO:0006590	thyroid hormone generation(GO:0006590)
0.0	0.0	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.0	GO:0005984	disaccharide metabolic process(GO:0005984)
0.0	0.0	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.0	GO:0002360	T cell lineage commitment(GO:0002360)
0.0	0.0	GO:0032632	interleukin-3 production(GO:0032632)
0.0	0.0	GO:0051148	negative regulation of muscle cell differentiation(GO:0051148)
0.0	0.2	GO:0007257	activation of JUN kinase activity(GO:0007257)
0.0	0.2	GO:0007340	acrosome reaction(GO:0007340)
0.0	0.0	GO:0002830	positive regulation of type 2 immune response(GO:0002830)
0.0	0.1	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.1	GO:0043616	keratinocyte proliferation(GO:0043616)
0.0	0.0	GO:0046021	regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0	0.0	GO:0060009	Sertoli cell development(GO:0060009)
0.0	0.2	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0	0.2	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0	0.0	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.0	GO:0060157	urinary bladder development(GO:0060157)
0.0	0.0	GO:0015870	acetylcholine transport(GO:0015870) acetate ester transport(GO:1901374)
0.0	0.0	GO:0032971	regulation of muscle filament sliding(GO:0032971) regulation of actin filament-based movement(GO:1903115)
0.0	0.1	GO:0006554	lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0	0.0	GO:0048261	negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0	0.1	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732)
0.0	0.1	GO:0018214	peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0	0.0	GO:0000212	meiotic spindle organization(GO:0000212)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0043260	laminin-11 complex(GO:0043260)
0.1	GO:0031045	dense core granule(GO:0031045)
0.1	GO:0032432	actin filament bundle(GO:0032432)
0.1	GO:0005594	collagen type IX trimer(GO:0005594)
0.1	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.2	GO:0042599	lamellar body(GO:0042599)
0.2	GO:0001950	obsolete plasma membrane enriched fraction(GO:0001950)
0.0	GO:0005593	FACIT collagen trimer(GO:0005593)
0.2	GO:0098645	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.5	GO:0030057	desmosome(GO:0030057)
0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.3	GO:0035631	CD40 receptor complex(GO:0035631)
0.3	GO:0005605	basal lamina(GO:0005605)
0.1	GO:0016342	catenin complex(GO:0016342)
0.1	GO:0001652	granular component(GO:0001652)
0.1	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.1	GO:0072487	MSL complex(GO:0072487)
0.1	GO:0032009	early phagosome(GO:0032009)
0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.1	GO:0005827	polar microtubule(GO:0005827)
0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2	GO:0030128	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.7	GO:0042641	actomyosin(GO:0042641)
0.1	GO:0002080	acrosomal membrane(GO:0002080)
0.1	GO:0005861	troponin complex(GO:0005861)
0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.1	GO:0030056	hemidesmosome(GO:0030056)
0.1	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.2	GO:0043034	costamere(GO:0043034)
0.1	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	GO:0005766	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	GO:0070062	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.1	GO:0031527	filopodium membrane(GO:0031527)
0.3	GO:0005811	lipid particle(GO:0005811)
0.0	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.2	GO:0005771	multivesicular body(GO:0005771)
0.0	GO:0030934	anchoring collagen complex(GO:0030934)
0.1	GO:0030315	T-tubule(GO:0030315)
0.1	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.3	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.1	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.0	GO:0014704	intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.1	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	GO:0005641	nuclear envelope lumen(GO:0005641)
0.5	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.0	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.2	GO:0005913	cell-cell adherens junction(GO:0005913)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0070644	vitamin D response element binding(GO:0070644)
0.1	0.2	GO:0048018	receptor agonist activity(GO:0048018)
0.1	0.2	GO:0031545	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1	0.2	GO:0004104	cholinesterase activity(GO:0004104)
0.0	0.2	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.4	GO:0005112	Notch binding(GO:0005112)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0031014	troponin T binding(GO:0031014)
0.0	0.3	GO:0016165	linoleate 13S-lipoxygenase activity(GO:0016165)
0.0	0.1	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.1	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0050698	proteoglycan sulfotransferase activity(GO:0050698)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.2	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0	0.1	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.2	GO:0070215	obsolete MDM2 binding(GO:0070215)
0.0	0.2	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.4	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.1	GO:0031705	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.1	GO:0019855	calcium channel inhibitor activity(GO:0019855)
0.0	0.1	GO:0004966	galanin receptor activity(GO:0004966)
0.0	0.1	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
0.0	0.1	GO:0016728	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.1	GO:0004849	uridine kinase activity(GO:0004849)
0.0	0.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.1	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.1	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	0.2	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.2	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.1	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0	0.1	GO:0019958	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.1	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0	0.2	GO:0005402	sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
0.0	0.1	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	0.2	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0004967	glucagon receptor activity(GO:0004967)
0.0	0.3	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.1	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.1	GO:0022897	peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0	0.2	GO:0030371	translation repressor activity(GO:0030371)
0.0	0.1	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.1	GO:0005219	ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0	0.1	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.0	0.1	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0	0.1	GO:0003923	GPI-anchor transamidase activity(GO:0003923)
0.0	0.1	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.3	GO:0035254	glutamate receptor binding(GO:0035254)
0.0	0.2	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.1	GO:0004457	lactate dehydrogenase activity(GO:0004457)
0.0	0.1	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.1	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607)
0.0	0.1	GO:0004111	creatine kinase activity(GO:0004111)
0.0	0.0	GO:0002060	purine nucleobase binding(GO:0002060)
0.0	0.1	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.1	GO:0015278	calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0	0.1	GO:0008504	monoamine transmembrane transporter activity(GO:0008504)
0.0	0.2	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0	0.1	GO:0099602	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0	0.2	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.1	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0016413	O-acetyltransferase activity(GO:0016413)
0.0	0.1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.0	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.1	GO:0048019	receptor antagonist activity(GO:0048019)
0.0	0.0	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.0	0.0	GO:0031432	titin binding(GO:0031432)
0.0	0.1	GO:0050780	dopamine receptor binding(GO:0050780)
0.0	0.0	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.0	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.0	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.0	GO:0015142	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0	0.1	GO:0090599	alpha-glucosidase activity(GO:0090599)
0.0	0.0	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.1	GO:0031404	chloride ion binding(GO:0031404)
0.0	0.1	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.2	GO:0034483	heparan sulfate sulfotransferase activity(GO:0034483)
0.0	0.1	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.6	GO:0008307	structural constituent of muscle(GO:0008307)
0.0	0.1	GO:0017049	GTP-Rho binding(GO:0017049)
0.0	0.0	GO:0005113	patched binding(GO:0005113)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.0	GO:0070326	very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0	0.2	GO:0042301	phosphate ion binding(GO:0042301)
0.0	0.1	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.1	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.1	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.1	GO:0051920	peroxiredoxin activity(GO:0051920)
0.0	0.2	GO:0031490	chromatin DNA binding(GO:0031490)
0.0	0.0	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.0	GO:0002054	nucleobase binding(GO:0002054)
0.0	0.0	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.2	GO:0005003	ephrin receptor activity(GO:0005003)
0.0	0.0	GO:0015254	glycerol channel activity(GO:0015254)
0.0	0.0	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
0.0	0.1	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.1	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.1	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
0.0	0.0	GO:0070052	collagen V binding(GO:0070052)
0.0	0.1	GO:0005497	androgen binding(GO:0005497)
0.0	0.1	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.0	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.1	GO:0043560	insulin receptor substrate binding(GO:0043560)
0.0	0.1	GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.0	0.0	GO:0031628	opioid receptor binding(GO:0031628)
0.0	0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.0	GO:0030235	nitric-oxide synthase regulator activity(GO:0030235)
0.0	0.2	GO:0050699	WW domain binding(GO:0050699)
0.0	0.1	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.0	0.0	GO:0031994	insulin-like growth factor I binding(GO:0031994)
0.0	0.0	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.0	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.0	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.0	GO:0015226	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0	0.0	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.1	GO:0022821	potassium ion antiporter activity(GO:0022821)
0.0	0.1	GO:0008252	nucleotidase activity(GO:0008252)
0.0	0.1	GO:0004415	hyalurononglucosaminidase activity(GO:0004415)
0.0	0.2	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.1	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.0	0.4	GO:0004714	transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0	0.0	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.2	GO:0042809	vitamin D receptor binding(GO:0042809)
0.0	0.2	GO:0043621	protein self-association(GO:0043621)
0.0	0.1	GO:0046625	sphingolipid binding(GO:0046625)
0.0	0.0	GO:0051731	polynucleotide 5'-hydroxyl-kinase activity(GO:0051731)
0.0	0.1	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
0.0	0.2	GO:0051117	ATPase binding(GO:0051117)
0.0	0.1	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.0	GO:0032190	acrosin binding(GO:0032190)
0.0	0.1	GO:0043015	gamma-tubulin binding(GO:0043015)
0.0	0.1	GO:0051400	BH domain binding(GO:0051400)
0.0	0.2	GO:0008378	galactosyltransferase activity(GO:0008378)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.3	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.7	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.2	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.2	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.5	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.3	PID IGF1 PATHWAY	IGF1 pathway
0.0	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.5	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.3	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.3	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.0	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.4	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.1	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.3	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.5	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.4	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.3	PID AURORA A PATHWAY	Aurora A signaling
0.0	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.1	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.1	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	0.1	REACTOME SIGNALING BY FGFR	Genes involved in Signaling by FGFR
0.0	0.4	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.1	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.0	0.4	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.0	0.4	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.0	0.0	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0	0.3	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.0	0.2	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.0	0.2	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.4	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.4	REACTOME FGFR LIGAND BINDING AND ACTIVATION	Genes involved in FGFR ligand binding and activation
0.0	0.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.2	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.4	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	0.3	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.0	0.2	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.5	REACTOME NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Neurotransmitter Release Cycle
0.0	0.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.2	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	0.2	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.2	REACTOME SIGNALING BY NOTCH3	Genes involved in Signaling by NOTCH3
0.0	0.1	REACTOME SIGNALLING TO P38 VIA RIT AND RIN	Genes involved in Signalling to p38 via RIT and RIN
0.0	0.0	REACTOME SIGNALING BY ERBB2	Genes involved in Signaling by ERBB2
0.0	0.2	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0	0.3	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.4	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.0	0.1	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	0.0	REACTOME SHC MEDIATED SIGNALLING	Genes involved in SHC-mediated signalling
0.0	0.1	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.0	0.1	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0	0.1	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	0.0	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.0	0.2	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
0.0	0.0	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions