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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ETS1

Z-value: 1.53

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Transcription factors associated with ETS1

Gene Symbol	Gene ID	Gene Info
ETS1 Ensembl NCBI GeneCards UniProt	ENSG00000134954.10	ETS1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ETS1	chr11_127910618_127910769	464596	0.005531	0.81	7.8e-03	Click!
ETS1	chr11_128321217_128321474	53944	0.155393	-0.75	1.9e-02	Click!
ETS1	chr11_128089758_128089909	285456	0.013976	-0.69	4.0e-02	Click!
ETS1	chr11_128457168_128457319	210	0.955960	-0.66	5.2e-02	Click!
ETS1	chr11_128364559_128364710	10655	0.248798	0.64	6.5e-02	Click!

Activity of the ETS1 motif across conditions

Conditions sorted by the z-value of the ETS1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr2_242556723_242557374	0.80	THAP4	THAP domain containing 4	132	0.94
chr22_33040519_33040909	0.76	ENSG00000251890	.	9530	0.25
chrX_129225814_129226276	0.71	ELF4	E74-like factor 4 (ets domain transcription factor)	18291	0.19
chrX_4158791_4158942	0.67	ENSG00000264861	.	342675	0.01
chr7_150329208_150329551	0.67	GIMAP6	GTPase, IMAP family member 6	55	0.98
chr1_206732541_206732911	0.61	RASSF5	Ras association (RalGDS/AF-6) domain family member 5	2233	0.27
chr17_4618141_4618477	0.59	ARRB2	arrestin, beta 2	575	0.53
chr1_79111525_79111735	0.57	IFI44	interferon-induced protein 44	3886	0.26
chr2_61095077_61095367	0.56	REL	v-rel avian reticuloendotheliosis viral oncogene homolog	13434	0.18
chr22_17700031_17700512	0.55	CECR1	cat eye syndrome chromosome region, candidate 1	5	0.98
chr10_75625259_75625477	0.54	CAMK2G	calcium/calmodulin-dependent protein kinase II gamma	4756	0.13
chr22_27067492_27067685	0.54	CRYBA4	crystallin, beta A4	49660	0.13
chr15_100049921_100050072	0.54	AC015660.1	HCG1993240; Serologically defined breast cancer antigen NY-BR-40; Uncharacterized protein	11418	0.22
chr3_101441272_101441423	0.53	CEP97	centrosomal protein 97kDa	1422	0.34
chr22_37637445_37637596	0.53	RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	2768	0.2
chr9_95726568_95726886	0.51	FGD3	FYVE, RhoGEF and PH domain containing 3	484	0.84
chr2_198157762_198157913	0.51	ANKRD44-IT1	ANKRD44 intronic transcript 1 (non-protein coding)	9406	0.17
chr14_101034010_101035263	0.51	BEGAIN	brain-enriched guanylate kinase-associated	192	0.93
chr8_66863582_66864279	0.50	DNAJC5B	DnaJ (Hsp40) homolog, subfamily C, member 5 beta	69865	0.12
chr3_67133876_67134122	0.49	KBTBD8	kelch repeat and BTB (POZ) domain containing 8	84650	0.11
chr3_197831468_197832400	0.49	AC073135.3		5143	0.19
chr6_225379_225671	0.49	DUSP22	dual specificity phosphatase 22	66105	0.15
chr6_41168130_41168571	0.48	TREML2	triggering receptor expressed on myeloid cells-like 2	582	0.65
chr9_126628860_126629011	0.48	DENND1A	DENN/MADD domain containing 1A	63451	0.12
chr17_4336857_4337447	0.47	SPNS3	spinster homolog 3 (Drosophila)	67	0.97
chr10_29528746_29529040	0.47	LYZL1	lysozyme-like 1	49097	0.18
chr21_42741926_42742138	0.47	MX2	myxovirus (influenza virus) resistance 2 (mouse)	20	0.98
chr12_122075303_122075715	0.47	ORAI1	ORAI calcium release-activated calcium modulator 1	10788	0.17
chr1_9777067_9777879	0.47	PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	654	0.69
chr22_37637600_37637886	0.46	RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	2545	0.22
chr2_112913175_112913326	0.46	FBLN7	fibulin 7	4075	0.29
chr17_38478388_38479657	0.45	RARA	retinoic acid receptor, alpha	4485	0.13
chr10_134260489_134261029	0.44	C10orf91	chromosome 10 open reading frame 91	2066	0.3
chr1_156124352_156124692	0.43	SEMA4A	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	360	0.78
chr2_234327510_234328202	0.43	DGKD	diacylglycerol kinase, delta 130kDa	31056	0.14
chr4_2800484_2801318	0.43	SH3BP2	SH3-domain binding protein 2	176	0.95
chr22_39148225_39148574	0.42	SUN2	Sad1 and UNC84 domain containing 2	2080	0.14
chr9_132890415_132890884	0.42	ENSG00000223188	.	7564	0.19
chr1_203734376_203734572	0.41	LAX1	lymphocyte transmembrane adaptor 1	169	0.94
chr3_140985922_140986285	0.41	ACPL2	acid phosphatase-like 2	4647	0.28
chr12_56323213_56323608	0.41	DGKA	diacylglycerol kinase, alpha 80kDa	802	0.4
chr17_80063977_80064793	0.40	CCDC57	coiled-coil domain containing 57	4659	0.1
chr14_24906611_24906867	0.40	SDR39U1	short chain dehydrogenase/reductase family 39U, member 1	3518	0.13
chr7_50727890_50728167	0.39	GRB10	growth factor receptor-bound protein 10	33401	0.21
chr7_97878599_97878750	0.39	TECPR1	tectonin beta-propeller repeat containing 1	2565	0.27
chr10_126300385_126300576	0.39	FAM53B-AS1	FAM53B antisense RNA 1	91714	0.07
chr15_40746159_40746352	0.39	RP11-64K12.9		583	0.57
chr1_198648918_198649184	0.39	RP11-553K8.5		12861	0.25
chr17_72459969_72460120	0.39	CD300A	CD300a molecule	2511	0.22
chr6_32160504_32160787	0.39	GPSM3	G-protein signaling modulator 3	0	0.94
chrX_3061320_3061471	0.38	ARSF	arylsulfatase F	76521	0.09
chr2_196444875_196445026	0.38	SLC39A10	solute carrier family 39 (zinc transporter), member 10	4249	0.31
chr5_172272383_172272534	0.38	ERGIC1	endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1	11044	0.19
chr8_130983839_130984300	0.38	FAM49B	family with sequence similarity 49, member B	833	0.63
chr4_6912691_6912996	0.38	TBC1D14	TBC1 domain family, member 14	868	0.61
chr3_111264316_111264467	0.38	CD96	CD96 molecule	3394	0.32
chr13_41579755_41579906	0.38	ELF1	E74-like factor 1 (ets domain transcription factor)	13620	0.19
chr17_11683304_11683455	0.37	ENSG00000263623	.	38598	0.18
chr1_247570490_247571007	0.37	NLRP3	NLR family, pyrin domain containing 3	8710	0.18
chr5_14594534_14594878	0.37	FAM105A	family with sequence similarity 105, member A	12822	0.24
chr9_132023537_132023688	0.37	ENSG00000220992	.	30616	0.15
chr4_140481827_140481978	0.37	RP11-342I1.2		3949	0.22
chr3_16883969_16884348	0.36	PLCL2	phospholipase C-like 2	42294	0.19
chr18_74836287_74836734	0.36	MBP	myelin basic protein	3158	0.38
chr18_77166229_77166515	0.36	NFATC1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	5980	0.26
chr6_35338140_35338402	0.36	PPARD	peroxisome proliferator-activated receptor delta	27869	0.16
chr10_119125041_119125192	0.36	ENSG00000222197	.	7249	0.22
chr15_38852692_38852843	0.35	RASGRP1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	287	0.91
chr10_43947307_43947516	0.35	ENSG00000252532	.	6102	0.17
chr16_28506747_28507012	0.35	CLN3	ceroid-lipofuscinosis, neuronal 3	24	0.94
chr1_234980313_234980644	0.35	ENSG00000201638	.	6758	0.28
chr16_71915132_71915582	0.34	RP11-498D10.3		819	0.43
chr3_177662001_177662152	0.34	ENSG00000199858	.	63491	0.15
chr5_137416910_137417200	0.34	WNT8A	wingless-type MMTV integration site family, member 8A	2526	0.17
chr2_113873876_113874027	0.34	IL1RN	interleukin 1 receptor antagonist	1519	0.32
chr9_95716277_95716712	0.34	FGD3	FYVE, RhoGEF and PH domain containing 3	6761	0.23
chr12_58158605_58159703	0.33	CYP27B1	cytochrome P450, family 27, subfamily B, polypeptide 1	314	0.7
chr5_118676288_118676442	0.33	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	7495	0.22
chr22_50319474_50319638	0.33	CRELD2	cysteine-rich with EGF-like domains 2	7175	0.17
chr6_99792225_99792376	0.33	FAXC	failed axon connections homolog (Drosophila)	1490	0.45
chr6_35465033_35465928	0.33	TEAD3	TEA domain family member 3	627	0.7
chr12_53024457_53024608	0.32	KRT73	keratin 73	12189	0.1
chr10_73531555_73531706	0.32	C10orf54	chromosome 10 open reading frame 54	1625	0.38
chr4_38611399_38611550	0.32	RP11-617D20.1		14722	0.22
chr5_544016_544540	0.32	ENSG00000264233	.	8281	0.14
chr17_47765494_47765708	0.32	SPOP	speckle-type POZ protein	10005	0.14
chr12_6571175_6571326	0.32	VAMP1	vesicle-associated membrane protein 1 (synaptobrevin 1)	8561	0.09
chr2_127942699_127942861	0.32	CYP27C1	cytochrome P450, family 27, subfamily C, polypeptide 1	20563	0.22
chr20_23063904_23064055	0.32	CD93	CD93 molecule	2998	0.23
chr15_67442847_67442998	0.31	RP11-342M21.2	Uncharacterized protein	3645	0.27
chr5_176784624_176784924	0.31	RGS14	regulator of G-protein signaling 14	64	0.95
chr1_25252115_25252332	0.31	RUNX3	runt-related transcription factor 3	3389	0.28
chr16_79123602_79124194	0.31	RP11-556H2.3		49	0.98
chr3_15332172_15332523	0.31	SH3BP5	SH3-domain binding protein 5 (BTK-associated)	14795	0.14
chr3_113252540_113252793	0.31	SIDT1	SID1 transmembrane family, member 1	1448	0.4
chr7_106505707_106506635	0.31	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	247	0.95
chr12_54866933_54867431	0.31	GTSF1	gametocyte specific factor 1	201	0.92
chr17_3693803_3693954	0.31	ITGAE	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	10659	0.14
chr16_30915019_30915170	0.30	CTF1	cardiotrophin 1	7135	0.08
chr6_144665292_144666004	0.30	UTRN	utrophin	411	0.88
chr2_101171356_101171507	0.30	ENSG00000266005	.	1081	0.48
chr10_65001333_65001484	0.30	JMJD1C	jumonji domain containing 1C	27418	0.22
chr20_35258352_35258894	0.30	SLA2	Src-like-adaptor 2	15661	0.12
chr22_39147860_39148011	0.30	SUN2	Sad1 and UNC84 domain containing 2	1616	0.18
chr7_2684869_2685165	0.30	TTYH3	tweety family member 3	149	0.96
chr11_128587302_128587453	0.30	SENCR	smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA	21459	0.17
chr6_35279100_35279566	0.30	DEF6	differentially expressed in FDCP 6 homolog (mouse)	1818	0.34
chr14_22979723_22979978	0.30	TRAJ15	T cell receptor alpha joining 15	18730	0.09
chrX_65294918_65295209	0.30	VSIG4	V-set and immunoglobulin domain containing 4	35096	0.18
chr10_94590680_94591107	0.30	EXOC6	exocyst complex component 6	42	0.99
chr16_78776918_78777171	0.30	RP11-319G9.3		154018	0.04
chr17_66344269_66344555	0.30	ARSG	arylsulfatase G	56753	0.1
chr11_65407442_65407916	0.30	SIPA1	signal-induced proliferation-associated 1	87	0.92
chr1_27945148_27945299	0.30	FGR	feline Gardner-Rasheed sarcoma viral oncogene homolog	5350	0.15
chr1_90312219_90312370	0.30	LRRC8D	leucine rich repeat containing 8 family, member D	155	0.97
chr12_51714745_51715007	0.30	BIN2	bridging integrator 2	3023	0.21
chr6_36923610_36923761	0.29	PI16	peptidase inhibitor 16	1476	0.38
chr6_114130917_114131144	0.29	ENSG00000253091	.	28363	0.16
chr1_154925966_154926117	0.29	PBXIP1	pre-B-cell leukemia homeobox interacting protein 1	2539	0.12
chr3_42543385_42544225	0.29	VIPR1	vasoactive intestinal peptide receptor 1	299	0.89
chr2_12267962_12268113	0.29	ENSG00000264089	.	71219	0.12
chr22_36730567_36730805	0.29	ENSG00000266345	.	18440	0.17
chr14_91882732_91883366	0.29	CCDC88C	coiled-coil domain containing 88C	641	0.78
chr22_17566954_17567330	0.29	IL17RA	interleukin 17 receptor A	1293	0.41
chr3_188077055_188077206	0.29	LPP	LIM domain containing preferred translocation partner in lipoma	119478	0.06
chr22_32039117_32039268	0.29	PISD	phosphatidylserine decarboxylase	4761	0.23
chr10_126339527_126339678	0.28	FAM53B-AS1	FAM53B antisense RNA 1	52592	0.13
chr15_65184402_65184553	0.28	ENSG00000264929	.	7961	0.15
chr6_154571300_154571451	0.28	IPCEF1	interaction protein for cytohesin exchange factors 1	2559	0.43
chr1_2347968_2348198	0.28	PEX10	peroxisomal biogenesis factor 10	2847	0.15
chr13_30528667_30528971	0.28	LINC00572	long intergenic non-protein coding RNA 572	28031	0.25
chr2_106363218_106363369	0.28	NCK2	NCK adaptor protein 2	1105	0.66
chr4_37759806_37759957	0.28	ENSG00000207075	.	58257	0.12
chr14_91608686_91608837	0.28	C14orf159	chromosome 14 open reading frame 159	5361	0.17
chr7_149647429_149647580	0.28	ATP6V0E2-AS1	ATP6V0E2 antisense RNA 1	69805	0.1
chr1_212968265_212968416	0.28	TATDN3	TatD DNase domain containing 3	315	0.88
chr17_62705322_62705475	0.27	SMURF2	SMAD specific E3 ubiquitin protein ligase 2	47212	0.12
chr1_27286933_27287204	0.27	C1orf172	chromosome 1 open reading frame 172	171	0.93
chr14_22989819_22990019	0.27	TRAJ15	T cell receptor alpha joining 15	8661	0.11
chr10_121277005_121277156	0.27	RGS10	regulator of G-protein signaling 10	9909	0.25
chr19_16698320_16698560	0.27	MED26	mediator complex subunit 26	28	0.83
chr22_38023673_38023836	0.27	SH3BP1	SH3-domain binding protein 1	11728	0.1
chr2_51231032_51231183	0.27	NRXN1	neurexin 1	24304	0.21
chr11_46367528_46367907	0.26	DGKZ	diacylglycerol kinase, zeta	730	0.6
chr2_121363693_121363844	0.26	ENSG00000201006	.	45081	0.19
chr10_11187446_11187644	0.26	CELF2	CUGBP, Elav-like family member 2	19448	0.19
chr12_80747054_80747205	0.26	OTOGL	otogelin-like	3005	0.29
chr13_24798397_24798604	0.26	SPATA13	spermatogenesis associated 13	27332	0.16
chr13_40466947_40467177	0.26	ENSG00000212553	.	35698	0.22
chr17_37033575_37033782	0.26	LASP1	LIM and SH3 protein 1	3535	0.12
chr1_31222830_31222981	0.26	LAPTM5	lysosomal protein transmembrane 5	7762	0.16
chr19_35740232_35740383	0.26	LSR	lipolysis stimulated lipoprotein receptor	303	0.79
chr10_14659345_14659496	0.26	FAM107B	family with sequence similarity 107, member B	4869	0.24
chrX_70838155_70838405	0.25	CXCR3	chemokine (C-X-C motif) receptor 3	80	0.97
chr12_10220623_10220774	0.25	ENSG00000223042	.	16087	0.12
chrX_56791675_56792116	0.25	ENSG00000204272	.	36203	0.23
chr9_35649649_35650491	0.25	SIT1	signaling threshold regulating transmembrane adaptor 1	867	0.32
chr12_46611822_46611973	0.25	SLC38A1	solute carrier family 38, member 1	49587	0.18
chr3_156360650_156360801	0.25	TIPARP-AS1	TIPARP antisense RNA 1	29934	0.18
chr1_110416375_110416526	0.25	RP11-195M16.1		12436	0.18
chr1_42073785_42073936	0.25	RP11-486B10.3		72746	0.1
chr1_154982220_154982994	0.25	ZBTB7B	zinc finger and BTB domain containing 7B	4317	0.08
chr5_169075790_169075941	0.25	DOCK2	dedicator of cytokinesis 2	11614	0.25
chr4_48139910_48140061	0.25	TXK	TXK tyrosine kinase	3712	0.2
chr2_175357999_175358525	0.25	GPR155	G protein-coupled receptor 155	6440	0.21
chr7_26333293_26333815	0.25	SNX10	sorting nexin 10	880	0.67
chr2_112940980_112941186	0.25	FBLN7	fibulin 7	1623	0.45
chr1_94459122_94459273	0.25	ABCA4	ATP-binding cassette, sub-family A (ABC1), member 4	17984	0.22
chr6_42743118_42743455	0.24	GLTSCR1L	GLTSCR1-like	6479	0.18
chr3_197825673_197826397	0.24	AC073135.3		11042	0.16
chr11_8111770_8111921	0.24	TUB	tubby bipartite transcription factor	8936	0.16
chr9_95716734_95716885	0.24	FGD3	FYVE, RhoGEF and PH domain containing 3	7076	0.22
chr16_28505762_28506015	0.24	APOBR	apolipoprotein B receptor	82	0.93
chr14_22343272_22343423	0.24	ENSG00000222776	.	94562	0.08
chr3_183273606_183273960	0.24	KLHL6	kelch-like family member 6	306	0.89
chr6_143177934_143178085	0.24	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	19825	0.26
chr19_55084758_55085279	0.24	LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	200	0.63
chr10_75624935_75625135	0.24	CAMK2G	calcium/calmodulin-dependent protein kinase II gamma	4423	0.13
chr11_6251374_6251525	0.24	FAM160A2	family with sequence similarity 160, member A2	4397	0.13
chr15_28381443_28381594	0.24	OCA2	oculocutaneous albinism II	37014	0.18
chr17_25793367_25793654	0.24	RP11-720N19.2		1372	0.44
chr7_100484820_100485063	0.24	SRRT	serrate RNA effector molecule homolog (Arabidopsis)	383	0.71
chr21_15922641_15922820	0.24	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	4066	0.28
chr8_22437861_22438169	0.24	PDLIM2	PDZ and LIM domain 2 (mystique)	12	0.95
chr12_104871725_104872091	0.24	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	21129	0.25
chr7_142000915_142001066	0.24	PRSS3P3	protease, serine, 3 pseudogene 3	11381	0.22
chr11_116722246_116722635	0.24	SIK3	SIK family kinase 3	2586	0.16
chr14_105953334_105954468	0.24	CRIP1	cysteine-rich protein 1 (intestinal)	647	0.53
chr8_134084504_134084857	0.23	SLA	Src-like-adaptor	12077	0.24
chr22_51059908_51060313	0.23	ARSA	arylsulfatase A	6473	0.1
chr6_112078758_112079082	0.23	FYN	FYN oncogene related to SRC, FGR, YES	1397	0.55
chr20_8134073_8134224	0.23	PLCB1	phospholipase C, beta 1 (phosphoinositide-specific)	20846	0.25
chr4_164480063_164480214	0.23	ENSG00000264535	.	35694	0.17
chr4_125821414_125821565	0.23	ANKRD50	ankyrin repeat domain 50	187602	0.03
chr3_146520537_146520688	0.23	ENSG00000251800	.	151253	0.04
chrX_131121415_131121857	0.23	ENSG00000265686	.	9237	0.22
chr22_23493647_23493798	0.23	RAB36	RAB36, member RAS oncogene family	1422	0.3
chr6_166747166_166747317	0.23	SFT2D1	SFT2 domain containing 1	8838	0.19
chr1_161038546_161039545	0.23	ARHGAP30	Rho GTPase activating protein 30	411	0.65
chr2_237780403_237780554	0.23	ENSG00000202341	.	143470	0.04

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ETS1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.2	0.5	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.1	0.4	GO:0006154	adenosine catabolic process(GO:0006154)
0.1	0.3	GO:0016242	negative regulation of macroautophagy(GO:0016242)
0.1	0.3	GO:0035455	response to interferon-alpha(GO:0035455)
0.1	0.2	GO:0033622	integrin activation(GO:0033622)
0.1	0.2	GO:0010815	bradykinin catabolic process(GO:0010815)
0.1	0.2	GO:0000089	mitotic metaphase(GO:0000089)
0.1	0.4	GO:0007172	signal complex assembly(GO:0007172)
0.1	0.9	GO:0046834	lipid phosphorylation(GO:0046834)
0.1	0.2	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.1	GO:0001845	phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.0	0.1	GO:0048680	positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0	0.2	GO:0045630	positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.0	0.2	GO:0031053	primary miRNA processing(GO:0031053)
0.0	0.1	GO:0007207	phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0	0.2	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.2	GO:0010867	positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0	0.1	GO:0072385	minus-end-directed organelle transport along microtubule(GO:0072385)
0.0	0.1	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.1	GO:0048143	astrocyte activation(GO:0048143)
0.0	0.2	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.0	0.1	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.1	GO:0030581	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.1	GO:0055064	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.2	GO:0071392	cellular response to estradiol stimulus(GO:0071392)
0.0	0.1	GO:0032966	negative regulation of collagen biosynthetic process(GO:0032966)
0.0	0.1	GO:0032237	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.2	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.2	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.1	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.9	GO:0046847	filopodium assembly(GO:0046847)
0.0	0.2	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.1	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.1	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.2	GO:0045672	positive regulation of osteoclast differentiation(GO:0045672)
0.0	0.1	GO:0060081	membrane hyperpolarization(GO:0060081)
0.0	0.4	GO:0001954	positive regulation of cell-matrix adhesion(GO:0001954)
0.0	0.1	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.1	GO:0072367	regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0	0.1	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.2	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.1	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.1	GO:0009405	pathogenesis(GO:0009405)
0.0	0.1	GO:0033261	obsolete regulation of S phase(GO:0033261)
0.0	0.0	GO:0042268	regulation of cytolysis(GO:0042268)
0.0	0.1	GO:0014002	astrocyte development(GO:0014002)
0.0	0.2	GO:0045577	regulation of B cell differentiation(GO:0045577)
0.0	0.1	GO:0021508	floor plate formation(GO:0021508)
0.0	0.0	GO:0046882	negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0	0.1	GO:0046325	negative regulation of glucose transport(GO:0010829) negative regulation of glucose import(GO:0046325)
0.0	0.2	GO:0050706	regulation of interleukin-1 beta secretion(GO:0050706)
0.0	0.0	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0	0.1	GO:1901538	DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.0	0.1	GO:0051136	NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0	0.0	GO:0060242	contact inhibition(GO:0060242)
0.0	0.1	GO:0015816	glycine transport(GO:0015816)
0.0	0.1	GO:0032928	regulation of superoxide anion generation(GO:0032928)
0.0	0.1	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.0	0.2	GO:0006911	phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.0	GO:0030812	negative regulation of nucleotide catabolic process(GO:0030812)
0.0	0.1	GO:0019605	butyrate metabolic process(GO:0019605)
0.0	0.2	GO:0015671	oxygen transport(GO:0015671)
0.0	0.3	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.5	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.1	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.1	GO:0042668	auditory receptor cell fate determination(GO:0042668)
0.0	0.0	GO:0046931	pore complex assembly(GO:0046931)
0.0	0.2	GO:0002467	germinal center formation(GO:0002467)
0.0	0.1	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.1	GO:0001766	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) membrane raft localization(GO:0051665)
0.0	0.1	GO:0045885	obsolete positive regulation of survival gene product expression(GO:0045885)
0.0	0.1	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.1	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.2	GO:0007158	neuron cell-cell adhesion(GO:0007158)
0.0	0.1	GO:0048679	regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0	0.1	GO:0032753	positive regulation of interleukin-4 production(GO:0032753)
0.0	0.1	GO:0060992	response to fungicide(GO:0060992)
0.0	0.1	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0	0.1	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.0	GO:0034204	lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0	0.1	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.1	GO:0042816	pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.2	GO:0031648	protein destabilization(GO:0031648)
0.0	0.1	GO:0015669	gas transport(GO:0015669)
0.0	0.0	GO:0009215	purine deoxyribonucleoside triphosphate metabolic process(GO:0009215)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.1	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.0	GO:0036037	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.1	GO:0018027	peptidyl-lysine dimethylation(GO:0018027)
0.0	0.0	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.1	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.1	GO:0050685	positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.0	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0050858	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.2	GO:0015701	bicarbonate transport(GO:0015701)
0.0	0.0	GO:0045409	negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0	0.0	GO:0050849	negative regulation of calcium-mediated signaling(GO:0050849)
0.0	0.1	GO:0042364	water-soluble vitamin biosynthetic process(GO:0042364)
0.0	0.0	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.0	GO:0043324	eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.0	0.0	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.1	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.1	GO:0032703	negative regulation of interleukin-2 production(GO:0032703)
0.0	0.7	GO:0031294	lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0	0.0	GO:0043276	anoikis(GO:0043276)
0.0	0.0	GO:0045007	depurination(GO:0045007)
0.0	0.1	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.0	GO:0035588	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.1	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.0	GO:0046021	regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0	0.1	GO:0051642	centrosome localization(GO:0051642)
0.0	0.1	GO:0033962	cytoplasmic mRNA processing body assembly(GO:0033962)
0.0	0.0	GO:0045651	positive regulation of macrophage differentiation(GO:0045651)
0.0	0.1	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.2	GO:0042994	cytoplasmic sequestering of transcription factor(GO:0042994)
0.0	0.0	GO:0072531	pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0	0.0	GO:0060585	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0	0.1	GO:0006884	cell volume homeostasis(GO:0006884)
0.0	0.1	GO:0030033	microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0	0.0	GO:0048548	regulation of pinocytosis(GO:0048548)
0.0	0.0	GO:0002326	B cell lineage commitment(GO:0002326)
0.0	0.1	GO:0015693	magnesium ion transport(GO:0015693)
0.0	0.0	GO:0045048	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.0	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.0	GO:0015705	iodide transport(GO:0015705)
0.0	0.0	GO:0035283	central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0	0.1	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0	0.0	GO:0071803	regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0	0.0	GO:0045349	interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.0	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
0.0	0.1	GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.0	0.1	GO:0009129	pyrimidine nucleoside monophosphate metabolic process(GO:0009129)
0.0	0.1	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.0	GO:0034626	fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.2	GO:0006825	copper ion transport(GO:0006825)
0.0	0.0	GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010)
0.0	0.0	GO:0070828	heterochromatin assembly(GO:0031507) heterochromatin organization(GO:0070828)
0.0	0.0	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	0.2	GO:0007032	endosome organization(GO:0007032)
0.0	0.0	GO:0010887	negative regulation of cholesterol storage(GO:0010887)
0.0	0.1	GO:0008655	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0	0.0	GO:0051409	response to nitrosative stress(GO:0051409)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	0.2	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0	0.3	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.6	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.5	GO:0042627	chylomicron(GO:0042627)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.2	GO:0000145	exocyst(GO:0000145)
0.0	0.1	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.2	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.0	GO:0032449	CBM complex(GO:0032449)
0.0	0.2	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.1	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:0098984	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	0.1	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.1	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.1	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.0	GO:0030008	TRAPP complex(GO:0030008)
0.0	1.1	GO:0030027	lamellipodium(GO:0030027)
0.0	0.3	GO:0005776	autophagosome(GO:0005776)
0.0	0.1	GO:0000444	MIS12/MIND type complex(GO:0000444)
0.0	0.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.0	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.2	GO:0055038	recycling endosome membrane(GO:0055038)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.0	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.0	0.0	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.0	GO:0071001	U4/U6 snRNP(GO:0071001)
0.0	0.0	GO:0031264	death-inducing signaling complex(GO:0031264)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1	0.3	GO:0042608	T cell receptor binding(GO:0042608)
0.1	0.3	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.1	0.4	GO:0031685	adenosine receptor binding(GO:0031685)
0.1	0.2	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.1	0.2	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.1	0.4	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.1	0.4	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.3	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.3	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.2	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.3	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.2	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.1	GO:0004994	somatostatin receptor activity(GO:0004994)
0.0	0.1	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.0	0.1	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.2	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.2	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.0	0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.3	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.3	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0	0.1	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	0.1	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.2	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.1	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.1	GO:0001846	opsonin binding(GO:0001846)
0.0	0.1	GO:0031628	opioid receptor binding(GO:0031628)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.1	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0	0.1	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
0.0	0.1	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.3	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.0	GO:0052659	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.0	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.0	GO:0005275	amine transmembrane transporter activity(GO:0005275)
0.0	0.1	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.0	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.1	GO:0036041	long-chain fatty acid binding(GO:0036041)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.0	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.0	GO:0043559	insulin binding(GO:0043559)
0.0	0.1	GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0	0.3	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.0	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.0	0.0	GO:0015142	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.0	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.0	GO:0004142	diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0	0.8	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.0	GO:0008384	IkappaB kinase activity(GO:0008384)
0.0	0.3	GO:0043621	protein self-association(GO:0043621)
0.0	1.0	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	0.1	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.0	0.0	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.3	GO:0005484	SNAP receptor activity(GO:0005484)
0.0	0.2	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.0	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.1	GO:0004985	opioid receptor activity(GO:0004985)
0.0	0.2	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.2	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.2	GO:0031683	G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0	0.2	GO:0016805	dipeptidase activity(GO:0016805)
0.0	0.0	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)
0.0	0.1	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	0.1	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
0.0	0.0	GO:0019959	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0003993	acid phosphatase activity(GO:0003993)
0.0	0.1	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)
0.0	0.1	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.0	GO:0016972	thiol oxidase activity(GO:0016972)
0.0	0.1	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.1	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.2	GO:0042169	SH2 domain binding(GO:0042169)
0.0	0.1	GO:0034235	GPI anchor binding(GO:0034235)
0.0	0.0	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.0	GO:0008061	chitin binding(GO:0008061)
0.0	0.0	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.0	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.3	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.0	0.1	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.0	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.4	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.0	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.2	GO:0043014	alpha-tubulin binding(GO:0043014)
0.0	0.1	GO:0004550	nucleoside diphosphate kinase activity(GO:0004550)
0.0	0.0	GO:0031014	troponin T binding(GO:0031014)
0.0	0.2	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0	0.1	GO:0046965	retinoid X receptor binding(GO:0046965)
0.0	0.1	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.1	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	0.6	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	3.0	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	1.0	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	0.4	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	0.5	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.6	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	0.1	PID IGF1 PATHWAY	IGF1 pathway
0.0	0.3	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.0	0.4	PID BCR 5PATHWAY	BCR signaling pathway
0.0	0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	0.0	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	0.5	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.2	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.0	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	0.1	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	0.1	PID S1P S1P3 PATHWAY	S1P3 pathway
0.0	0.3	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.0	0.1	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.7	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.4	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.1	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0	0.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.2	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	0.8	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.3	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.3	REACTOME GLUCAGON TYPE LIGAND RECEPTORS	Genes involved in Glucagon-type ligand receptors
0.0	0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.2	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.1	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.0	0.3	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	0.0	REACTOME ORC1 REMOVAL FROM CHROMATIN	Genes involved in Orc1 removal from chromatin
0.0	0.9	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	0.7	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	0.4	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0	0.0	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.2	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.0	0.0	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.0	REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.0	0.9	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.1	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells
0.0	0.2	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.2	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	0.2	REACTOME TCR SIGNALING	Genes involved in TCR signaling
0.0	0.3	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.2	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.1	REACTOME IL 2 SIGNALING	Genes involved in Interleukin-2 signaling
0.0	0.3	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.0	0.1	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.2	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.0	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.0	0.1	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.1	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.2	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.1	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated