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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for ETS1

Z-value: 1.53

Motif logo

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Transcription factors associated with ETS1

Gene Symbol Gene ID Gene Info
ETS1
ENSG00000134954.10 ETS proto-oncogene 1, transcription factor

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr11_127910618_127910769ETS14645960.0055310.817.8e-03Click!
chr11_128321217_128321474ETS1539440.155393-0.751.9e-02Click!
chr11_128089758_128089909ETS12854560.013976-0.694.0e-02Click!
chr11_128457168_128457319ETS12100.955960-0.665.2e-02Click!
chr11_128364559_128364710ETS1106550.2487980.646.5e-02Click!

Activity of the ETS1 motif across conditions

Conditions sorted by the z-value of the ETS1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr2_242556723_242557374 0.80 THAP4
 THAP domain containing 4
 132
 0.94
chr22_33040519_33040909 0.76 ENSG00000251890
 .
 9530
 0.25
chrX_129225814_129226276 0.71 ELF4
 E74-like factor 4 (ets domain transcription factor)
 18291
 0.19
chrX_4158791_4158942 0.67 ENSG00000264861
 .
 342675
 0.01
chr7_150329208_150329551 0.67 GIMAP6
 GTPase, IMAP family member 6
 55
 0.98
chr1_206732541_206732911 0.61 RASSF5
 Ras association (RalGDS/AF-6) domain family member 5
 2233
 0.27
chr17_4618141_4618477 0.59 ARRB2
 arrestin, beta 2
 575
 0.53
chr1_79111525_79111735 0.57 IFI44
 interferon-induced protein 44
 3886
 0.26
chr2_61095077_61095367 0.56 REL
 v-rel avian reticuloendotheliosis viral oncogene homolog
 13434
 0.18
chr22_17700031_17700512 0.55 CECR1
 cat eye syndrome chromosome region, candidate 1
 5
 0.98
chr10_75625259_75625477 0.54 CAMK2G
 calcium/calmodulin-dependent protein kinase II gamma
 4756
 0.13
chr22_27067492_27067685 0.54 CRYBA4
 crystallin, beta A4
 49660
 0.13
chr15_100049921_100050072 0.54 AC015660.1
 HCG1993240; Serologically defined breast cancer antigen NY-BR-40; Uncharacterized protein
 11418
 0.22
chr3_101441272_101441423 0.53 CEP97
 centrosomal protein 97kDa
 1422
 0.34
chr22_37637445_37637596 0.53 RAC2
 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
 2768
 0.2
chr9_95726568_95726886 0.51 FGD3
 FYVE, RhoGEF and PH domain containing 3
 484
 0.84
chr2_198157762_198157913 0.51 ANKRD44-IT1
 ANKRD44 intronic transcript 1 (non-protein coding)
 9406
 0.17
chr14_101034010_101035263 0.51 BEGAIN
 brain-enriched guanylate kinase-associated
 192
 0.93
chr8_66863582_66864279 0.50 DNAJC5B
 DnaJ (Hsp40) homolog, subfamily C, member 5 beta
 69865
 0.12
chr3_67133876_67134122 0.49 KBTBD8
 kelch repeat and BTB (POZ) domain containing 8
 84650
 0.11
chr3_197831468_197832400 0.49 AC073135.3
5143
 0.19
chr6_225379_225671 0.49 DUSP22
 dual specificity phosphatase 22
 66105
 0.15
chr6_41168130_41168571 0.48 TREML2
 triggering receptor expressed on myeloid cells-like 2
 582
 0.65
chr9_126628860_126629011 0.48 DENND1A
 DENN/MADD domain containing 1A
 63451
 0.12
chr17_4336857_4337447 0.47 SPNS3
 spinster homolog 3 (Drosophila)
 67
 0.97
chr10_29528746_29529040 0.47 LYZL1
 lysozyme-like 1
 49097
 0.18
chr21_42741926_42742138 0.47 MX2
 myxovirus (influenza virus) resistance 2 (mouse)
 20
 0.98
chr12_122075303_122075715 0.47 ORAI1
 ORAI calcium release-activated calcium modulator 1
 10788
 0.17
chr1_9777067_9777879 0.47 PIK3CD
 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
 654
 0.69
chr22_37637600_37637886 0.46 RAC2
 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
 2545
 0.22
chr2_112913175_112913326 0.46 FBLN7
 fibulin 7
 4075
 0.29
chr17_38478388_38479657 0.45 RARA
 retinoic acid receptor, alpha
 4485
 0.13
chr10_134260489_134261029 0.44 C10orf91
 chromosome 10 open reading frame 91
 2066
 0.3
chr1_156124352_156124692 0.43 SEMA4A
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
 360
 0.78
chr2_234327510_234328202 0.43 DGKD
 diacylglycerol kinase, delta 130kDa
 31056
 0.14
chr4_2800484_2801318 0.43 SH3BP2
 SH3-domain binding protein 2
 176
 0.95
chr22_39148225_39148574 0.42 SUN2
 Sad1 and UNC84 domain containing 2
 2080
 0.14
chr9_132890415_132890884 0.42 ENSG00000223188
 .
 7564
 0.19
chr1_203734376_203734572 0.41 LAX1
 lymphocyte transmembrane adaptor 1
 169
 0.94
chr3_140985922_140986285 0.41 ACPL2
 acid phosphatase-like 2
 4647
 0.28
chr12_56323213_56323608 0.41 DGKA
 diacylglycerol kinase, alpha 80kDa
 802
 0.4
chr17_80063977_80064793 0.40 CCDC57
 coiled-coil domain containing 57
 4659
 0.1
chr14_24906611_24906867 0.40 SDR39U1
 short chain dehydrogenase/reductase family 39U, member 1
 3518
 0.13
chr7_50727890_50728167 0.39 GRB10
 growth factor receptor-bound protein 10
 33401
 0.21
chr7_97878599_97878750 0.39 TECPR1
 tectonin beta-propeller repeat containing 1
 2565
 0.27
chr10_126300385_126300576 0.39 FAM53B-AS1
 FAM53B antisense RNA 1
 91714
 0.07
chr15_40746159_40746352 0.39 RP11-64K12.9
583
 0.57
chr1_198648918_198649184 0.39 RP11-553K8.5
12861
 0.25
chr17_72459969_72460120 0.39 CD300A
 CD300a molecule
 2511
 0.22
chr6_32160504_32160787 0.39 GPSM3
 G-protein signaling modulator 3
 0
 0.94
chrX_3061320_3061471 0.38 ARSF
 arylsulfatase F
 76521
 0.09
chr2_196444875_196445026 0.38 SLC39A10
 solute carrier family 39 (zinc transporter), member 10
 4249
 0.31
chr5_172272383_172272534 0.38 ERGIC1
 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
 11044
 0.19
chr8_130983839_130984300 0.38 FAM49B
 family with sequence similarity 49, member B
 833
 0.63
chr4_6912691_6912996 0.38 TBC1D14
 TBC1 domain family, member 14
 868
 0.61
chr3_111264316_111264467 0.38 CD96
 CD96 molecule
 3394
 0.32
chr13_41579755_41579906 0.38 ELF1
 E74-like factor 1 (ets domain transcription factor)
 13620
 0.19
chr17_11683304_11683455 0.37 ENSG00000263623
 .
 38598
 0.18
chr1_247570490_247571007 0.37 NLRP3
 NLR family, pyrin domain containing 3
 8710
 0.18
chr5_14594534_14594878 0.37 FAM105A
 family with sequence similarity 105, member A
 12822
 0.24
chr9_132023537_132023688 0.37 ENSG00000220992
 .
 30616
 0.15
chr4_140481827_140481978 0.37 RP11-342I1.2
3949
 0.22
chr3_16883969_16884348 0.36 PLCL2
 phospholipase C-like 2
 42294
 0.19
chr18_74836287_74836734 0.36 MBP
 myelin basic protein
 3158
 0.38
chr18_77166229_77166515 0.36 NFATC1
 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
 5980
 0.26
chr6_35338140_35338402 0.36 PPARD
 peroxisome proliferator-activated receptor delta
 27869
 0.16
chr10_119125041_119125192 0.36 ENSG00000222197
 .
 7249
 0.22
chr15_38852692_38852843 0.35 RASGRP1
 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
 287
 0.91
chr10_43947307_43947516 0.35 ENSG00000252532
 .
 6102
 0.17
chr16_28506747_28507012 0.35 CLN3
 ceroid-lipofuscinosis, neuronal 3
 24
 0.94
chr1_234980313_234980644 0.35 ENSG00000201638
 .
 6758
 0.28
chr16_71915132_71915582 0.34 RP11-498D10.3
819
 0.43
chr3_177662001_177662152 0.34 ENSG00000199858
 .
 63491
 0.15
chr5_137416910_137417200 0.34 WNT8A
 wingless-type MMTV integration site family, member 8A
 2526
 0.17
chr2_113873876_113874027 0.34 IL1RN
 interleukin 1 receptor antagonist
 1519
 0.32
chr9_95716277_95716712 0.34 FGD3
 FYVE, RhoGEF and PH domain containing 3
 6761
 0.23
chr12_58158605_58159703 0.33 CYP27B1
 cytochrome P450, family 27, subfamily B, polypeptide 1
 314
 0.7
chr5_118676288_118676442 0.33 TNFAIP8
 tumor necrosis factor, alpha-induced protein 8
 7495
 0.22
chr22_50319474_50319638 0.33 CRELD2
 cysteine-rich with EGF-like domains 2
 7175
 0.17
chr6_99792225_99792376 0.33 FAXC
 failed axon connections homolog (Drosophila)
 1490
 0.45
chr6_35465033_35465928 0.33 TEAD3
 TEA domain family member 3
 627
 0.7
chr12_53024457_53024608 0.32 KRT73
 keratin 73
 12189
 0.1
chr10_73531555_73531706 0.32 C10orf54
 chromosome 10 open reading frame 54
 1625
 0.38
chr4_38611399_38611550 0.32 RP11-617D20.1
14722
 0.22
chr5_544016_544540 0.32 ENSG00000264233
 .
 8281
 0.14
chr17_47765494_47765708 0.32 SPOP
 speckle-type POZ protein
 10005
 0.14
chr12_6571175_6571326 0.32 VAMP1
 vesicle-associated membrane protein 1 (synaptobrevin 1)
 8561
 0.09
chr2_127942699_127942861 0.32 CYP27C1
 cytochrome P450, family 27, subfamily C, polypeptide 1
 20563
 0.22
chr20_23063904_23064055 0.32 CD93
 CD93 molecule
 2998
 0.23
chr15_67442847_67442998 0.31 RP11-342M21.2
 Uncharacterized protein
 3645
 0.27
chr5_176784624_176784924 0.31 RGS14
 regulator of G-protein signaling 14
 64
 0.95
chr1_25252115_25252332 0.31 RUNX3
 runt-related transcription factor 3
 3389
 0.28
chr16_79123602_79124194 0.31 RP11-556H2.3
49
 0.98
chr3_15332172_15332523 0.31 SH3BP5
 SH3-domain binding protein 5 (BTK-associated)
 14795
 0.14
chr3_113252540_113252793 0.31 SIDT1
 SID1 transmembrane family, member 1
 1448
 0.4
chr7_106505707_106506635 0.31 PIK3CG
 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
 247
 0.95
chr12_54866933_54867431 0.31 GTSF1
 gametocyte specific factor 1
 201
 0.92
chr17_3693803_3693954 0.31 ITGAE
 integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
 10659
 0.14
chr16_30915019_30915170 0.30 CTF1
 cardiotrophin 1
 7135
 0.08
chr6_144665292_144666004 0.30 UTRN
 utrophin
 411
 0.88
chr2_101171356_101171507 0.30 ENSG00000266005
 .
 1081
 0.48
chr10_65001333_65001484 0.30 JMJD1C
 jumonji domain containing 1C
 27418
 0.22
chr20_35258352_35258894 0.30 SLA2
 Src-like-adaptor 2
 15661
 0.12
chr22_39147860_39148011 0.30 SUN2
 Sad1 and UNC84 domain containing 2
 1616
 0.18
chr7_2684869_2685165 0.30 TTYH3
 tweety family member 3
 149
 0.96
chr11_128587302_128587453 0.30 SENCR
 smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA
 21459
 0.17
chr6_35279100_35279566 0.30 DEF6
 differentially expressed in FDCP 6 homolog (mouse)
 1818
 0.34
chr14_22979723_22979978 0.30 TRAJ15
 T cell receptor alpha joining 15
 18730
 0.09
chrX_65294918_65295209 0.30 VSIG4
 V-set and immunoglobulin domain containing 4
 35096
 0.18
chr10_94590680_94591107 0.30 EXOC6
 exocyst complex component 6
 42
 0.99
chr16_78776918_78777171 0.30 RP11-319G9.3
154018
 0.04
chr17_66344269_66344555 0.30 ARSG
 arylsulfatase G
 56753
 0.1
chr11_65407442_65407916 0.30 SIPA1
 signal-induced proliferation-associated 1
 87
 0.92
chr1_27945148_27945299 0.30 FGR
 feline Gardner-Rasheed sarcoma viral oncogene homolog
 5350
 0.15
chr1_90312219_90312370 0.30 LRRC8D
 leucine rich repeat containing 8 family, member D
 155
 0.97
chr12_51714745_51715007 0.30 BIN2
 bridging integrator 2
 3023
 0.21
chr6_36923610_36923761 0.29 PI16
 peptidase inhibitor 16
 1476
 0.38
chr6_114130917_114131144 0.29 ENSG00000253091
 .
 28363
 0.16
chr1_154925966_154926117 0.29 PBXIP1
 pre-B-cell leukemia homeobox interacting protein 1
 2539
 0.12
chr3_42543385_42544225 0.29 VIPR1
 vasoactive intestinal peptide receptor 1
 299
 0.89
chr2_12267962_12268113 0.29 ENSG00000264089
 .
 71219
 0.12
chr22_36730567_36730805 0.29 ENSG00000266345
 .
 18440
 0.17
chr14_91882732_91883366 0.29 CCDC88C
 coiled-coil domain containing 88C
 641
 0.78
chr22_17566954_17567330 0.29 IL17RA
 interleukin 17 receptor A
 1293
 0.41
chr3_188077055_188077206 0.29 LPP
 LIM domain containing preferred translocation partner in lipoma
 119478
 0.06
chr22_32039117_32039268 0.29 PISD
 phosphatidylserine decarboxylase
 4761
 0.23
chr10_126339527_126339678 0.28 FAM53B-AS1
 FAM53B antisense RNA 1
 52592
 0.13
chr15_65184402_65184553 0.28 ENSG00000264929
 .
 7961
 0.15
chr6_154571300_154571451 0.28 IPCEF1
 interaction protein for cytohesin exchange factors 1
 2559
 0.43
chr1_2347968_2348198 0.28 PEX10
 peroxisomal biogenesis factor 10
 2847
 0.15
chr13_30528667_30528971 0.28 LINC00572
 long intergenic non-protein coding RNA 572
 28031
 0.25
chr2_106363218_106363369 0.28 NCK2
 NCK adaptor protein 2
 1105
 0.66
chr4_37759806_37759957 0.28 ENSG00000207075
 .
 58257
 0.12
chr14_91608686_91608837 0.28 C14orf159
 chromosome 14 open reading frame 159
 5361
 0.17
chr7_149647429_149647580 0.28 ATP6V0E2-AS1
 ATP6V0E2 antisense RNA 1
 69805
 0.1
chr1_212968265_212968416 0.28 TATDN3
 TatD DNase domain containing 3
 315
 0.88
chr17_62705322_62705475 0.27 SMURF2
 SMAD specific E3 ubiquitin protein ligase 2
 47212
 0.12
chr1_27286933_27287204 0.27 C1orf172
 chromosome 1 open reading frame 172
 171
 0.93
chr14_22989819_22990019 0.27 TRAJ15
 T cell receptor alpha joining 15
 8661
 0.11
chr10_121277005_121277156 0.27 RGS10
 regulator of G-protein signaling 10
 9909
 0.25
chr19_16698320_16698560 0.27 MED26
 mediator complex subunit 26
 28
 0.83
chr22_38023673_38023836 0.27 SH3BP1
 SH3-domain binding protein 1
 11728
 0.1
chr2_51231032_51231183 0.27 NRXN1
 neurexin 1
 24304
 0.21
chr11_46367528_46367907 0.26 DGKZ
 diacylglycerol kinase, zeta
 730
 0.6
chr2_121363693_121363844 0.26 ENSG00000201006
 .
 45081
 0.19
chr10_11187446_11187644 0.26 CELF2
 CUGBP, Elav-like family member 2
 19448
 0.19
chr12_80747054_80747205 0.26 OTOGL
 otogelin-like
 3005
 0.29
chr13_24798397_24798604 0.26 SPATA13
 spermatogenesis associated 13
 27332
 0.16
chr13_40466947_40467177 0.26 ENSG00000212553
 .
 35698
 0.22
chr17_37033575_37033782 0.26 LASP1
 LIM and SH3 protein 1
 3535
 0.12
chr1_31222830_31222981 0.26 LAPTM5
 lysosomal protein transmembrane 5
 7762
 0.16
chr19_35740232_35740383 0.26 LSR
 lipolysis stimulated lipoprotein receptor
 303
 0.79
chr10_14659345_14659496 0.26 FAM107B
 family with sequence similarity 107, member B
 4869
 0.24
chrX_70838155_70838405 0.25 CXCR3
 chemokine (C-X-C motif) receptor 3
 80
 0.97
chr12_10220623_10220774 0.25 ENSG00000223042
 .
 16087
 0.12
chrX_56791675_56792116 0.25 ENSG00000204272
 .
 36203
 0.23
chr9_35649649_35650491 0.25 SIT1
 signaling threshold regulating transmembrane adaptor 1
 867
 0.32
chr12_46611822_46611973 0.25 SLC38A1
 solute carrier family 38, member 1
 49587
 0.18
chr3_156360650_156360801 0.25 TIPARP-AS1
 TIPARP antisense RNA 1
 29934
 0.18
chr1_110416375_110416526 0.25 RP11-195M16.1
12436
 0.18
chr1_42073785_42073936 0.25 RP11-486B10.3
72746
 0.1
chr1_154982220_154982994 0.25 ZBTB7B
 zinc finger and BTB domain containing 7B
 4317
 0.08
chr5_169075790_169075941 0.25 DOCK2
 dedicator of cytokinesis 2
 11614
 0.25
chr4_48139910_48140061 0.25 TXK
 TXK tyrosine kinase
 3712
 0.2
chr2_175357999_175358525 0.25 GPR155
 G protein-coupled receptor 155
 6440
 0.21
chr7_26333293_26333815 0.25 SNX10
 sorting nexin 10
 880
 0.67
chr2_112940980_112941186 0.25 FBLN7
 fibulin 7
 1623
 0.45
chr1_94459122_94459273 0.25 ABCA4
 ATP-binding cassette, sub-family A (ABC1), member 4
 17984
 0.22
chr6_42743118_42743455 0.24 GLTSCR1L
 GLTSCR1-like
 6479
 0.18
chr3_197825673_197826397 0.24 AC073135.3
11042
 0.16
chr11_8111770_8111921 0.24 TUB
 tubby bipartite transcription factor
 8936
 0.16
chr9_95716734_95716885 0.24 FGD3
 FYVE, RhoGEF and PH domain containing 3
 7076
 0.22
chr16_28505762_28506015 0.24 APOBR
 apolipoprotein B receptor
 82
 0.93
chr14_22343272_22343423 0.24 ENSG00000222776
 .
 94562
 0.08
chr3_183273606_183273960 0.24 KLHL6
 kelch-like family member 6
 306
 0.89
chr6_143177934_143178085 0.24 HIVEP2
 human immunodeficiency virus type I enhancer binding protein 2
 19825
 0.26
chr19_55084758_55085279 0.24 LILRA2
 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
 200
 0.63
chr10_75624935_75625135 0.24 CAMK2G
 calcium/calmodulin-dependent protein kinase II gamma
 4423
 0.13
chr11_6251374_6251525 0.24 FAM160A2
 family with sequence similarity 160, member A2
 4397
 0.13
chr15_28381443_28381594 0.24 OCA2
 oculocutaneous albinism II
 37014
 0.18
chr17_25793367_25793654 0.24 RP11-720N19.2
1372
 0.44
chr7_100484820_100485063 0.24 SRRT
 serrate RNA effector molecule homolog (Arabidopsis)
 383
 0.71
chr21_15922641_15922820 0.24 SAMSN1
 SAM domain, SH3 domain and nuclear localization signals 1
 4066
 0.28
chr8_22437861_22438169 0.24 PDLIM2
 PDZ and LIM domain 2 (mystique)
 12
 0.95
chr12_104871725_104872091 0.24 CHST11
 carbohydrate (chondroitin 4) sulfotransferase 11
 21129
 0.25
chr7_142000915_142001066 0.24 PRSS3P3
 protease, serine, 3 pseudogene 3
 11381
 0.22
chr11_116722246_116722635 0.24 SIK3
 SIK family kinase 3
 2586
 0.16
chr14_105953334_105954468 0.24 CRIP1
 cysteine-rich protein 1 (intestinal)
 647
 0.53
chr8_134084504_134084857 0.23 SLA
 Src-like-adaptor
 12077
 0.24
chr22_51059908_51060313 0.23 ARSA
 arylsulfatase A
 6473
 0.1
chr6_112078758_112079082 0.23 FYN
 FYN oncogene related to SRC, FGR, YES
 1397
 0.55
chr20_8134073_8134224 0.23 PLCB1
 phospholipase C, beta 1 (phosphoinositide-specific)
 20846
 0.25
chr4_164480063_164480214 0.23 ENSG00000264535
 .
 35694
 0.17
chr4_125821414_125821565 0.23 ANKRD50
 ankyrin repeat domain 50
 187602
 0.03
chr3_146520537_146520688 0.23 ENSG00000251800
 .
 151253
 0.04
chrX_131121415_131121857 0.23 ENSG00000265686
 .
 9237
 0.22
chr22_23493647_23493798 0.23 RAB36
 RAB36, member RAS oncogene family
 1422
 0.3
chr6_166747166_166747317 0.23 SFT2D1
 SFT2 domain containing 1
 8838
 0.19
chr1_161038546_161039545 0.23 ARHGAP30
 Rho GTPase activating protein 30
 411
 0.65
chr2_237780403_237780554 0.23 ENSG00000202341
 .
 143470
 0.04

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of ETS1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.2 0.5 GO:0010956 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.1 0.4 GO:0006154 adenosine catabolic process(GO:0006154)
0.1 0.3 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.1 0.3 GO:0035455 response to interferon-alpha(GO:0035455)
0.1 0.2 GO:0033622 integrin activation(GO:0033622)
0.1 0.2 GO:0010815 bradykinin catabolic process(GO:0010815)
0.1 0.2 GO:0000089 mitotic metaphase(GO:0000089)
0.1 0.4 GO:0007172 signal complex assembly(GO:0007172)
0.1 0.9 GO:0046834 lipid phosphorylation(GO:0046834)
0.1 0.2 GO:0032506 cytokinetic process(GO:0032506)
0.0 0.1 GO:0001845 phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.0 0.1 GO:0048680 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0 0.2 GO:0045630 positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.0 0.2 GO:0031053 primary miRNA processing(GO:0031053)
0.0 0.1 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 0.2 GO:0001866 NK T cell proliferation(GO:0001866)
0.0 0.2 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0 0.1 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.0 0.1 GO:0043578 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.1 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:0048143 astrocyte activation(GO:0048143)
0.0 0.2 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.1 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0030581 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0 0.1 GO:0055064 cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0 0.2 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.0 0.1 GO:0032966 negative regulation of collagen biosynthetic process(GO:0032966)
0.0 0.1 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.2 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.1 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.2 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.1 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:0070672 response to interleukin-15(GO:0070672)
0.0 0.9 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.2 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.1 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.1 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 0.2 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
0.0 0.1 GO:0060081 membrane hyperpolarization(GO:0060081)
0.0 0.4 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.0 0.1 GO:0015917 aminophospholipid transport(GO:0015917)
0.0 0.1 GO:0072367 regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0 0.1 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.2 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.1 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.1 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 0.1 GO:0009405 pathogenesis(GO:0009405)
0.0 0.1 GO:0033261 obsolete regulation of S phase(GO:0033261)
0.0 0.0 GO:0042268 regulation of cytolysis(GO:0042268)
0.0 0.1 GO:0014002 astrocyte development(GO:0014002)
0.0 0.2 GO:0045577 regulation of B cell differentiation(GO:0045577)
0.0 0.1 GO:0021508 floor plate formation(GO:0021508)
0.0 0.0 GO:0046882 negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0 0.1 GO:0046325 negative regulation of glucose transport(GO:0010829) negative regulation of glucose import(GO:0046325)
0.0 0.2 GO:0050706 regulation of interleukin-1 beta secretion(GO:0050706)
0.0 0.0 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0 0.1 GO:1901538 DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.0 0.1 GO:0051136 NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0 0.0 GO:0060242 contact inhibition(GO:0060242)
0.0 0.1 GO:0015816 glycine transport(GO:0015816)
0.0 0.1 GO:0032928 regulation of superoxide anion generation(GO:0032928)
0.0 0.1 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.0 0.2 GO:0006911 phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.0 GO:0030812 negative regulation of nucleotide catabolic process(GO:0030812)
0.0 0.1 GO:0019605 butyrate metabolic process(GO:0019605)
0.0 0.2 GO:0015671 oxygen transport(GO:0015671)
0.0 0.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.5 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.1 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.1 GO:0042668 auditory receptor cell fate determination(GO:0042668)
0.0 0.0 GO:0046931 pore complex assembly(GO:0046931)
0.0 0.2 GO:0002467 germinal center formation(GO:0002467)
0.0 0.1 GO:0006106 fumarate metabolic process(GO:0006106)
0.0 0.1 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) membrane raft localization(GO:0051665)
0.0 0.1 GO:0045885 obsolete positive regulation of survival gene product expression(GO:0045885)
0.0 0.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.1 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.2 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.0 0.1 GO:0048679 regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0 0.1 GO:0032753 positive regulation of interleukin-4 production(GO:0032753)
0.0 0.1 GO:0060992 response to fungicide(GO:0060992)
0.0 0.1 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.1 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 0.0 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0 0.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0042816 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0 0.1 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.2 GO:0031648 protein destabilization(GO:0031648)
0.0 0.1 GO:0015669 gas transport(GO:0015669)
0.0 0.0 GO:0009215 purine deoxyribonucleoside triphosphate metabolic process(GO:0009215)
0.0 0.1 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.1 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.0 GO:0036037 CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.1 GO:0018027 peptidyl-lysine dimethylation(GO:0018027)
0.0 0.0 GO:0010831 positive regulation of myotube differentiation(GO:0010831)
0.0 0.1 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.0 0.1 GO:0050685 positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0 0.0 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.1 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.2 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.0 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0 0.0 GO:0050849 negative regulation of calcium-mediated signaling(GO:0050849)
0.0 0.1 GO:0042364 water-soluble vitamin biosynthetic process(GO:0042364)
0.0 0.0 GO:0043320 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0 0.0 GO:0043324 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.0 0.0 GO:0003032 detection of oxygen(GO:0003032)
0.0 0.1 GO:0071318 cellular response to ATP(GO:0071318)
0.0 0.1 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.0 0.7 GO:0031294 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 0.0 GO:0043276 anoikis(GO:0043276)
0.0 0.0 GO:0045007 depurination(GO:0045007)
0.0 0.1 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.0 GO:0035588 adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 0.1 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.0 GO:0046021 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0 0.1 GO:0051642 centrosome localization(GO:0051642)
0.0 0.1 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.0 0.0 GO:0045651 positive regulation of macrophage differentiation(GO:0045651)
0.0 0.1 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.0 0.2 GO:0042994 cytoplasmic sequestering of transcription factor(GO:0042994)
0.0 0.0 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0 0.0 GO:0060585 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.1 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 0.1 GO:0030033 microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0 0.0 GO:0048548 regulation of pinocytosis(GO:0048548)
0.0 0.0 GO:0002326 B cell lineage commitment(GO:0002326)
0.0 0.1 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.0 GO:0045048 protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.0 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.0 GO:0015705 iodide transport(GO:0015705)
0.0 0.0 GO:0035283 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 0.1 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.0 GO:0071803 regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0 0.0 GO:0045349 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.0 GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
0.0 0.1 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.0 0.1 GO:0009129 pyrimidine nucleoside monophosphate metabolic process(GO:0009129)
0.0 0.1 GO:0046835 carbohydrate phosphorylation(GO:0046835)
0.0 0.0 GO:0034626 fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.2 GO:0006825 copper ion transport(GO:0006825)
0.0 0.0 GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010)
0.0 0.0 GO:0070828 heterochromatin assembly(GO:0031507) heterochromatin organization(GO:0070828)
0.0 0.0 GO:0006498 N-terminal protein lipidation(GO:0006498)
0.0 0.2 GO:0007032 endosome organization(GO:0007032)
0.0 0.0 GO:0010887 negative regulation of cholesterol storage(GO:0010887)
0.0 0.1 GO:0008655 pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0 0.0 GO:0051409 response to nitrosative stress(GO:0051409)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 0.2 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0 0.3 GO:0005678 obsolete chromatin assembly complex(GO:0005678)
0.0 0.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.5 GO:0042627 chylomicron(GO:0042627)
0.0 0.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.2 GO:0000145 exocyst(GO:0000145)
0.0 0.1 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.1 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.0 GO:0032449 CBM complex(GO:0032449)
0.0 0.2 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.1 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.1 GO:0098984 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0 0.1 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.1 GO:0070695 FHF complex(GO:0070695)
0.0 0.1 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.0 GO:0030008 TRAPP complex(GO:0030008)
0.0 1.1 GO:0030027 lamellipodium(GO:0030027)
0.0 0.3 GO:0005776 autophagosome(GO:0005776)
0.0 0.1 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 0.1 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.0 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.0 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.0 0.0 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.0 GO:0071001 U4/U6 snRNP(GO:0071001)
0.0 0.0 GO:0031264 death-inducing signaling complex(GO:0031264)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1 0.3 GO:0042608 T cell receptor binding(GO:0042608)
0.1 0.3 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.1 0.4 GO:0031685 adenosine receptor binding(GO:0031685)
0.1 0.2 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 0.2 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.1 0.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 0.4 GO:0031701 angiotensin receptor binding(GO:0031701)
0.0 0.3 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.3 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.2 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.1 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.1 GO:0015379 potassium:chloride symporter activity(GO:0015379)
0.0 0.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.1 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.2 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.1 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.3 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.3 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 0.1 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.2 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.1 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.1 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.0 0.1 GO:0001846 opsonin binding(GO:0001846)
0.0 0.1 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.1 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.0 0.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.0 GO:0052659 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0 0.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.0 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.0 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.1 GO:0030955 potassium ion binding(GO:0030955)
0.0 0.0 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.1 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.0 0.1 GO:0005521 lamin binding(GO:0005521)
0.0 0.0 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.0 GO:0043559 insulin binding(GO:0043559)
0.0 0.1 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0 0.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.0 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.0 0.0 GO:0015142 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0 0.1 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.0 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.0 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0 0.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.0 GO:0008384 IkappaB kinase activity(GO:0008384)
0.0 0.3 GO:0043621 protein self-association(GO:0043621)
0.0 1.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.1 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.0 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.2 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.0 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.1 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.2 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.1 GO:0043495 protein anchor(GO:0043495)
0.0 0.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.2 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.2 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.0 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.1 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.1 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.0 GO:0019959 C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0 0.0 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.1 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.0 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.0 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 0.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.1 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.2 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.1 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.0 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.0 GO:0008061 chitin binding(GO:0008061)
0.0 0.0 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.0 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.1 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.0 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.0 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 0.2 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.1 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.0 GO:0031014 troponin T binding(GO:0031014)
0.0 0.2 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.1 GO:0046965 retinoid X receptor binding(GO:0046965)
0.0 0.1 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.1 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0 0.1 GO:0004908 interleukin-1 receptor activity(GO:0004908)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.6 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 3.0 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 1.0 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.4 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.5 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.6 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.1 PID IGF1 PATHWAY IGF1 pathway
0.0 0.3 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.4 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.1 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.1 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.0 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.5 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.2 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.0 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.1 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.1 PID S1P S1P3 PATHWAY S1P3 pathway
0.0 0.3 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 0.1 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.7 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.4 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.1 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.1 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.8 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.3 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.3 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.2 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.3 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.0 REACTOME ORC1 REMOVAL FROM CHROMATIN Genes involved in Orc1 removal from chromatin
0.0 0.9 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.7 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.4 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.0 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.2 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.0 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.0 REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.0 0.9 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.1 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 0.2 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.2 REACTOME TCR SIGNALING Genes involved in TCR signaling
0.0 0.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.2 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.1 REACTOME IL 2 SIGNALING Genes involved in Interleukin-2 signaling
0.0 0.3 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.1 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.2 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.0 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.1 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.1 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.2 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.1 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.1 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated