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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ETV2

Z-value: 0.96

Motif logo

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Transcription factors associated with ETV2

Gene Symbol Gene ID Gene Info
ETV2
ENSG00000105672.10 ETV2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
ETV2chr19_36136140_3613629116470.171867-0.353.6e-01Click!
ETV2chr19_36132782_361329331620.8842340.127.7e-01Click!
ETV2chr19_36132415_361325661570.8877750.098.3e-01Click!
ETV2chr19_36135542_3613600112030.2437400.088.4e-01Click!
ETV2chr19_36134803_361353395030.581797-0.078.6e-01Click!

Activity of the ETV2 motif across conditions

Conditions sorted by the z-value of the ETV2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr18_13464907_13465379 0.35 LDLRAD4
 low density lipoprotein receptor class A domain containing 4
 129
 0.93
chrX_111125456_111125607 0.31 TRPC5OS
 TRPC5 opposite strand
 406
 0.91
chr5_128680466_128680617 0.29 ENSG00000265691
 .
 52299
 0.16
chr7_150180608_150181504 0.27 GIMAP7
 GTPase, IMAP family member 7
 30862
 0.13
chr10_45409178_45409329 0.26 TMEM72
 transmembrane protein 72
 2489
 0.23
chr16_30915019_30915170 0.25 CTF1
 cardiotrophin 1
 7135
 0.08
chr5_57788132_57788386 0.25 GAPT
 GRB2-binding adaptor protein, transmembrane
 995
 0.57
chr16_89520011_89520290 0.23 ENSG00000252887
 .
 10424
 0.12
chr1_239883177_239883989 0.23 CHRM3
 cholinergic receptor, muscarinic 3
 740
 0.59
chr12_11954842_11955089 0.22 ETV6
 ets variant 6
 49530
 0.18
chr4_118904778_118905073 0.22 NDST3
 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
 50575
 0.19
chr7_150329208_150329551 0.21 GIMAP6
 GTPase, IMAP family member 6
 55
 0.98
chr12_104871725_104872091 0.21 CHST11
 carbohydrate (chondroitin 4) sulfotransferase 11
 21129
 0.25
chr11_117873994_117874145 0.21 IL10RA
 interleukin 10 receptor, alpha
 16960
 0.17
chr12_9912315_9912520 0.21 CD69
 CD69 molecule
 1080
 0.47
chr11_65409143_65409294 0.21 SIPA1
 signal-induced proliferation-associated 1
 919
 0.33
chr9_92092302_92093120 0.20 SEMA4D
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
 2094
 0.37
chr2_105461225_105461520 0.20 LINC01158
 long intergenic non-protein coding RNA 1158
 6539
 0.15
chr12_51640112_51640647 0.20 DAZAP2
 DAZ associated protein 2
 7300
 0.14
chr4_1717124_1717335 0.20 SLBP
 stem-loop binding protein
 2947
 0.18
chr9_78286476_78286627 0.20 ENSG00000238598
 .
 5272
 0.3
chr19_38539731_38539968 0.19 ENSG00000221258
 .
 4756
 0.2
chr17_56415064_56415366 0.19 BZRAP1-AS1
 BZRAP1 antisense RNA 1
 496
 0.64
chrX_111125134_111125285 0.19 TRPC5OS
 TRPC5 opposite strand
 84
 0.98
chr9_71611525_71611676 0.19 PRKACG
 protein kinase, cAMP-dependent, catalytic, gamma
 17439
 0.21
chr6_139646858_139647120 0.18 TXLNB
 taxilin beta
 33713
 0.16
chr19_44283473_44283624 0.18 KCNN4
 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
 1861
 0.24
chr2_230989553_230989704 0.18 AC009950.2
398
 0.87
chr1_161038546_161039545 0.18 ARHGAP30
 Rho GTPase activating protein 30
 411
 0.65
chr3_128211427_128211634 0.18 GATA2
 GATA binding protein 2
 486
 0.76
chr13_49828247_49828398 0.17 CDADC1
 cytidine and dCMP deaminase domain containing 1
 6138
 0.24
chr1_158624437_158624588 0.17 SPTA1
 spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
 31886
 0.12
chr1_221246452_221246603 0.17 HLX
 H2.0-like homeobox
 191943
 0.03
chr5_59544424_59544722 0.17 ENSG00000202017
 .
 55405
 0.15
chr10_15356030_15356181 0.17 FAM171A1
 family with sequence similarity 171, member A1
 56953
 0.14
chr1_66802739_66802890 0.17 PDE4B
 phosphodiesterase 4B, cAMP-specific
 4942
 0.34
chr6_119764039_119764190 0.17 MAN1A1
 mannosidase, alpha, class 1A, member 1
 93188
 0.09
chr15_32754386_32754537 0.17 GOLGA8O
 golgin A8 family, member O
 6626
 0.11
chr21_45577511_45577678 0.17 AP001055.1
15986
 0.13
chr7_150374007_150374169 0.17 GIMAP2
 GTPase, IMAP family member 2
 8700
 0.17
chr12_10396486_10396819 0.17 KLRD1
 killer cell lectin-like receptor subfamily D, member 1
 17995
 0.13
chr21_16433048_16433989 0.17 NRIP1
 nuclear receptor interacting protein 1
 3608
 0.34
chr7_38352490_38352648 0.17 STARD3NL
 STARD3 N-terminal like
 134572
 0.05
chr18_20254692_20254843 0.17 ENSG00000206827
 .
 27222
 0.21
chr20_3888044_3888195 0.16 ENSG00000199024
 .
 10022
 0.14
chr10_6604051_6604202 0.16 PRKCQ
 protein kinase C, theta
 18075
 0.29
chr12_92937765_92937916 0.16 ENSG00000238865
 .
 923
 0.69
chr12_15134766_15134917 0.16 PDE6H
 phosphodiesterase 6H, cGMP-specific, cone, gamma
 8885
 0.18
chr2_44464528_44464816 0.16 ENSG00000239052
 .
 2128
 0.31
chr20_43525395_43525569 0.16 YWHAB
 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
 11089
 0.14
chr2_68966105_68966288 0.16 ARHGAP25
 Rho GTPase activating protein 25
 4182
 0.3
chr2_106776864_106777181 0.16 UXS1
 UDP-glucuronate decarboxylase 1
 18
 0.98
chr3_47059139_47059290 0.16 NBEAL2
 neurobeachin-like 2
 12443
 0.18
chr2_234406495_234406646 0.16 USP40
 ubiquitin specific peptidase 40
 8463
 0.22
chr16_24994986_24995137 0.16 ARHGAP17
 Rho GTPase activating protein 17
 31591
 0.21
chr12_72039123_72039274 0.16 ENSG00000212461
 .
 6063
 0.17
chr19_52274682_52274833 0.15 FPR2
 formyl peptide receptor 2
 3126
 0.17
chr12_8309713_8309864 0.15 ZNF705A
 zinc finger protein 705A
 158
 0.94
chrX_138636602_138636753 0.15 F9
 coagulation factor IX
 23753
 0.2
chr5_130715501_130715652 0.15 CDC42SE2
 CDC42 small effector 2
 5723
 0.32
chr8_144437885_144438036 0.15 TOP1MT
 topoisomerase (DNA) I, mitochondrial
 256
 0.84
chr9_135248236_135248390 0.15 SETX
 senataxin
 17941
 0.17
chr2_175354938_175355089 0.15 GPR155
 G protein-coupled receptor 155
 3191
 0.26
chr11_14600078_14600336 0.15 PSMA1
 proteasome (prosome, macropain) subunit, alpha type, 1
 57965
 0.12
chr2_68592484_68592752 0.15 AC015969.3
98
 0.77
chr21_36772376_36772631 0.15 ENSG00000211590
 .
 320510
 0.01
chr12_2173143_2173560 0.15 CACNA1C
 calcium channel, voltage-dependent, L type, alpha 1C subunit
 10622
 0.17
chr7_148001198_148001349 0.15 ENSG00000199370
 .
 85468
 0.1
chr2_231733015_231733166 0.15 ITM2C
 integral membrane protein 2C
 2711
 0.25
chr5_74964815_74965486 0.15 ENSG00000207333
 .
 40274
 0.14
chr15_50570751_50570902 0.15 HDC
 histidine decarboxylase
 12603
 0.14
chr7_2286127_2286278 0.15 NUDT1
 nudix (nucleoside diphosphate linked moiety X)-type motif 1
 3662
 0.2
chr17_73064038_73064189 0.15 SLC16A5
 solute carrier family 16 (monocarboxylate transporter), member 5
 19709
 0.07
chr13_91922419_91922570 0.15 ENSG00000215417
 .
 80365
 0.12
chr21_15892777_15892928 0.15 SAMSN1
 SAM domain, SH3 domain and nuclear localization signals 1
 25810
 0.22
chr1_22402292_22402667 0.15 CDC42-IT1
 CDC42 intronic transcript 1 (non-protein coding)
 16789
 0.13
chr13_52570204_52570355 0.14 ATP7B
 ATPase, Cu++ transporting, beta polypeptide
 15268
 0.17
chr14_25143618_25143855 0.14 GZMB
 granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
 40263
 0.14
chr10_129861236_129861473 0.14 PTPRE
 protein tyrosine phosphatase, receptor type, E
 15520
 0.26
chr2_233703428_233703579 0.14 GIGYF2
 GRB10 interacting GYF protein 2
 4167
 0.17
chr6_53187554_53187810 0.14 ELOVL5
 ELOVL fatty acid elongase 5
 25905
 0.17
chr4_16600596_16600747 0.14 LDB2
 LIM domain binding 2
 3173
 0.4
chr9_96929356_96930067 0.14 ENSG00000199165
 .
 8523
 0.16
chr7_93485635_93485786 0.14 TFPI2
 tissue factor pathway inhibitor 2
 33772
 0.15
chr7_79736330_79736481 0.14 GNAI1
 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
 26866
 0.25
chr12_68953962_68954113 0.14 RAP1B
 RAP1B, member of RAS oncogene family
 50582
 0.15
chr8_130984307_130984565 0.14 FAM49B
 family with sequence similarity 49, member B
 1200
 0.49
chr14_61966690_61966841 0.14 RP11-47I22.4
29081
 0.17
chr6_15439743_15439894 0.14 JARID2
 jumonji, AT rich interactive domain 2
 38729
 0.19
chr15_101675976_101676127 0.14 RP11-505E24.2
49780
 0.14
chr12_27166173_27166337 0.14 TM7SF3
 transmembrane 7 superfamily member 3
 308
 0.87
chr2_54816819_54816970 0.14 SPTBN1
 spectrin, beta, non-erythrocytic 1
 31363
 0.16
chr7_4901206_4901513 0.14 PAPOLB
 poly(A) polymerase beta (testis specific)
 266
 0.91
chr11_1779321_1779700 0.14 RP11-295K3.1
771
 0.4
chr13_74339708_74339938 0.14 KLF12
 Kruppel-like factor 12
 229363
 0.02
chr15_34620156_34620427 0.14 SLC12A6
 solute carrier family 12 (potassium/chloride transporter), member 6
 8754
 0.11
chr10_94581983_94582410 0.14 EXOC6
 exocyst complex component 6
 8739
 0.28
chr14_70169921_70170072 0.14 SRSF5
 serine/arginine-rich splicing factor 5
 23621
 0.21
chr22_17956680_17956831 0.13 CECR2
 cat eye syndrome chromosome region, candidate 2
 128
 0.97
chr17_77755824_77755975 0.13 CBX2
 chromobox homolog 2
 3906
 0.16
chr19_55518051_55518213 0.13 CTC-550B14.7
559
 0.64
chr6_108775089_108775240 0.13 ENSG00000200799
 .
 61887
 0.13
chr10_126753392_126753897 0.13 ENSG00000264572
 .
 32205
 0.18
chr22_17700031_17700512 0.13 CECR1
 cat eye syndrome chromosome region, candidate 1
 5
 0.98
chr15_68967503_68967698 0.13 CORO2B
 coronin, actin binding protein, 2B
 43273
 0.18
chr22_39339167_39339454 0.13 APOBEC3A
 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
 9446
 0.14
chr17_76912321_76912483 0.13 TIMP2
 TIMP metallopeptidase inhibitor 2
 6081
 0.15
chr12_14410123_14410274 0.13 ENSG00000251908
 .
 6923
 0.23
chr5_126323849_126324159 0.13 MARCH3
 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
 42496
 0.18
chr15_66906109_66906400 0.13 RP11-321F6.1
 HCG2003567; Uncharacterized protein
 31726
 0.13
chr19_3136242_3137376 0.13 GNA15
 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
 618
 0.58
chr19_3812381_3812532 0.13 MATK
 megakaryocyte-associated tyrosine kinase
 10329
 0.11
chr15_50411143_50411548 0.13 ATP8B4
 ATPase, class I, type 8B, member 4
 74
 0.98
chr6_170404507_170404739 0.13 RP11-302L19.1
73118
 0.11
chr15_64231749_64232239 0.13 RP11-111E14.1
11521
 0.22
chr11_78061880_78062257 0.13 GAB2
 GRB2-associated binding protein 2
 9142
 0.19
chr8_8648717_8648916 0.13 CLDN23
 claudin 23
 89368
 0.08
chr12_111883856_111884007 0.13 ATXN2
 ataxin 2
 9985
 0.18
chr10_7513829_7514374 0.13 ENSG00000207453
 .
 14670
 0.24
chr17_7239932_7240900 0.13 ACAP1
 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
 507
 0.51
chr9_124248312_124248463 0.13 ENSG00000240299
 .
 8410
 0.21
chr7_138779576_138780000 0.13 ZC3HAV1
 zinc finger CCCH-type, antiviral 1
 14312
 0.2
chr11_128554784_128555228 0.13 RP11-744N12.3
1317
 0.34
chr7_128777310_128777461 0.13 TSPAN33
 tetraspanin 33
 7327
 0.16
chr1_240655111_240655262 0.13 AL646016.1
 Uncharacterized protein
 11682
 0.21
chrX_111124795_111124946 0.13 TRPC5OS
 TRPC5 opposite strand
 255
 0.96
chr7_137619960_137620169 0.13 CREB3L2
 cAMP responsive element binding protein 3-like 2
 1428
 0.46
chr19_10450524_10450675 0.13 ICAM3
 intercellular adhesion molecule 3
 100
 0.92
chr15_52121866_52123371 0.13 TMOD3
 tropomodulin 3 (ubiquitous)
 791
 0.61
chr17_48393570_48393721 0.13 RP11-893F2.9
28429
 0.09
chr10_11252091_11252492 0.13 RP3-323N1.2
38952
 0.17
chr2_136690107_136690258 0.13 DARS
 aspartyl-tRNA synthetase
 12059
 0.21
chr20_23065943_23066176 0.13 CD93
 CD93 molecule
 918
 0.56
chrX_9910123_9910274 0.13 AC002365.1
 Homo sapiens uncharacterized LOC100288814 (LOC100288814), mRNA.
 25194
 0.17
chr11_126206552_126206753 0.13 ST3GAL4
 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
 18903
 0.11
chr11_3968342_3968493 0.13 STIM1
 stromal interaction molecule 1
 156
 0.95
chr14_60620645_60620999 0.13 DHRS7
 dehydrogenase/reductase (SDR family) member 7
 930
 0.61
chr18_43405356_43405507 0.12 SIGLEC15
 sialic acid binding Ig-like lectin 15
 46
 0.98
chr16_57576997_57577182 0.12 GPR114
 G protein-coupled receptor 114
 488
 0.75
chr15_101472786_101472937 0.12 LRRK1
 leucine-rich repeat kinase 1
 13311
 0.19
chr2_46146841_46146992 0.12 PRKCE
 protein kinase C, epsilon
 81125
 0.11
chr7_26411915_26412066 0.12 AC004540.4
3902
 0.26
chr9_90132771_90132922 0.12 DAPK1
 death-associated protein kinase 1
 18926
 0.23
chr19_6100497_6100709 0.12 CTB-66B24.1
8730
 0.14
chr2_225792696_225792947 0.12 DOCK10
 dedicator of cytokinesis 10
 18961
 0.28
chr13_31270446_31270597 0.12 ALOX5AP
 arachidonate 5-lipoxygenase-activating protein
 39124
 0.18
chr12_54149865_54150016 0.12 CALCOCO1
 calcium binding and coiled-coil domain 1
 28411
 0.13
chr2_42598602_42598753 0.12 COX7A2L
 cytochrome c oxidase subunit VIIa polypeptide 2 like
 2527
 0.35
chr5_130882612_130883040 0.12 RAPGEF6
 Rap guanine nucleotide exchange factor (GEF) 6
 14100
 0.29
chr2_10263974_10264125 0.12 RRM2
 ribonucleotide reductase M2
 751
 0.54
chr17_1547959_1548110 0.12 SCARF1
 scavenger receptor class F, member 1
 1004
 0.36
chr15_65162716_65162867 0.12 AC069368.3
 Uncharacterized protein
 28644
 0.11
chr1_8971746_8971897 0.12 ENSG00000201725
 .
 28229
 0.11
chr4_78067033_78067281 0.12 ENSG00000201641
 .
 4433
 0.25
chrX_131155738_131155889 0.12 MST4
 Serine/threonine-protein kinase MST4
 1480
 0.46
chr5_39270144_39270372 0.12 FYB
 FYN binding protein
 488
 0.88
chr11_118085317_118085565 0.12 AMICA1
 adhesion molecule, interacts with CXADR antigen 1
 165
 0.94
chr10_7199494_7199645 0.12 SFMBT2
 Scm-like with four mbt domains 2
 251138
 0.02
chr3_148881073_148881224 0.12 CP
 ceruloplasmin (ferroxidase)
 16260
 0.18
chr2_27108927_27109078 0.12 DPYSL5
 dihydropyrimidinase-like 5
 37626
 0.13
chr10_967380_967531 0.12 LARP4B
 La ribonucleoprotein domain family, member 4B
 10109
 0.17
chrX_118815979_118816490 0.12 SEPT6
 septin 6
 10558
 0.17
chr4_99368056_99368277 0.12 RP11-724M22.1
49349
 0.16
chr5_134761441_134761660 0.12 C5orf20
 chromosome 5 open reading frame 20
 21488
 0.12
chr17_62159661_62159890 0.12 ERN1
 endoplasmic reticulum to nucleus signaling 1
 47710
 0.1
chr2_101196975_101197172 0.12 ENSG00000238328
 .
 3142
 0.22
chr22_38023673_38023836 0.12 SH3BP1
 SH3-domain binding protein 1
 11728
 0.1
chr12_47609896_47610314 0.12 PCED1B
 PC-esterase domain containing 1B
 53
 0.98
chr7_23511681_23511832 0.12 IGF2BP3
 insulin-like growth factor 2 mRNA binding protein 3
 1670
 0.34
chr6_41168130_41168571 0.12 TREML2
 triggering receptor expressed on myeloid cells-like 2
 582
 0.65
chr1_93644902_93645466 0.12 CCDC18
 coiled-coil domain containing 18
 292
 0.74
chr7_15276818_15277037 0.12 AGMO
 alkylglycerol monooxygenase
 128885
 0.06
chr12_50911115_50911266 0.12 DIP2B
 DIP2 disco-interacting protein 2 homolog B (Drosophila)
 12300
 0.22
chr7_1572516_1572667 0.12 MAFK
 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
 2241
 0.23
chr3_28390062_28390213 0.12 AZI2
 5-azacytidine induced 2
 17
 0.91
chr1_158978812_158979065 0.12 IFI16
 interferon, gamma-inducible protein 16
 153
 0.96
chr1_182237824_182238059 0.12 ENSG00000206764
 .
 58262
 0.14
chr2_70311208_70311359 0.12 PCBP1-AS1
 PCBP1 antisense RNA 1
 1422
 0.35
chr5_158444877_158445028 0.12 CTD-2363C16.2
32138
 0.18
chr6_114192994_114193566 0.12 MARCKS
 myristoylated alanine-rich protein kinase C substrate
 14739
 0.18
chr20_4792501_4792764 0.12 RASSF2
 Ras association (RalGDS/AF-6) domain family member 2
 3137
 0.27
chr6_110743031_110743182 0.12 DDO
 D-aspartate oxidase
 6341
 0.19
chr2_111610333_111610484 0.12 ACOXL
 acyl-CoA oxidase-like
 47512
 0.19
chr1_200209996_200210147 0.12 ENSG00000221403
 .
 96109
 0.08
chr8_17601172_17601375 0.12 ENSG00000212280
 .
 4354
 0.2
chr1_33399662_33399813 0.11 ENSG00000221423
 .
 7842
 0.14
chr1_6086479_6086932 0.11 KCNAB2
 potassium voltage-gated channel, shaker-related subfamily, beta member 2
 325
 0.88
chr8_61816196_61816783 0.11 RP11-33I11.2
94324
 0.09
chr7_26141262_26141558 0.11 ENSG00000266430
 .
 41451
 0.15
chr4_109267462_109267684 0.11 ENSG00000232021
 .
 170129
 0.03
chr14_93540208_93540361 0.11 ITPK1-AS1
 ITPK1 antisense RNA 1
 6487
 0.21
chr16_80598262_80598561 0.11 RP11-525K10.3
1379
 0.4
chr21_36881466_36881794 0.11 ENSG00000211590
 .
 211383
 0.02
chr16_23864221_23864482 0.11 PRKCB
 protein kinase C, beta
 15807
 0.23
chr2_200333840_200333991 0.11 SATB2-AS1
 SATB2 antisense RNA 1
 306
 0.9
chr2_16084260_16084411 0.11 MYCNOS
 MYCN opposite strand
 1964
 0.28
chr15_60296023_60296174 0.11 FOXB1
 forkhead box B1
 323
 0.94
chr13_78596306_78596606 0.11 RNF219-AS1
 RNF219 antisense RNA 1
 32524
 0.21
chr15_66702574_66702725 0.11 MAP2K1
 mitogen-activated protein kinase kinase 1
 23494
 0.11
chr3_53206269_53206420 0.11 PRKCD
 protein kinase C, delta
 7199
 0.18

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of ETV2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:1901339 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.2 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.0 0.1 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.0 GO:0002326 B cell lineage commitment(GO:0002326)
0.0 0.1 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.1 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.1 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.1 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.3 GO:0050718 positive regulation of interleukin-1 beta secretion(GO:0050718)
0.0 0.1 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 0.2 GO:0033261 obsolete regulation of S phase(GO:0033261)
0.0 0.1 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.1 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0 0.1 GO:0042663 endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0 0.1 GO:0009448 gamma-aminobutyric acid metabolic process(GO:0009448)
0.0 0.1 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0 0.1 GO:0042494 detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0 0.2 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.1 GO:0010957 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0 0.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.0 GO:0071220 response to bacterial lipoprotein(GO:0032493) response to bacterial lipopeptide(GO:0070339) cellular response to bacterial lipoprotein(GO:0071220) cellular response to bacterial lipopeptide(GO:0071221)
0.0 0.1 GO:0019372 lipoxygenase pathway(GO:0019372)
0.0 0.0 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065) UDP-glucuronate metabolic process(GO:0046398)
0.0 0.1 GO:0060431 primary lung bud formation(GO:0060431)
0.0 0.1 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.1 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.1 GO:0072600 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0 0.1 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.1 GO:0007132 meiotic metaphase I(GO:0007132)
0.0 0.0 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.0 GO:0002328 pro-B cell differentiation(GO:0002328)
0.0 0.1 GO:0050849 negative regulation of calcium-mediated signaling(GO:0050849)
0.0 0.2 GO:0045086 positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0 0.1 GO:0021799 cerebral cortex radially oriented cell migration(GO:0021799)
0.0 0.1 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.0 0.0 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
0.0 0.1 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.0 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.1 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 0.2 GO:0010822 positive regulation of mitochondrion organization(GO:0010822) positive regulation of release of cytochrome c from mitochondria(GO:0090200) positive regulation of apoptotic signaling pathway(GO:2001235)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0051852 disruption by host of symbiont cells(GO:0051852) killing by host of symbiont cells(GO:0051873)
0.0 0.0 GO:0048680 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0 0.1 GO:0035067 negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0 0.1 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744)
0.0 0.0 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.1 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0 0.1 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.0 GO:0014850 response to muscle activity(GO:0014850)
0.0 0.1 GO:0006265 DNA topological change(GO:0006265)
0.0 0.2 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.1 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0 0.0 GO:0046015 carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015)
0.0 0.0 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.0 0.0 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0 0.1 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.0 0.1 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.0 0.0 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.0 0.1 GO:0001782 B cell homeostasis(GO:0001782)
0.0 0.0 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.1 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.1 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0 0.2 GO:0043631 RNA polyadenylation(GO:0043631)
0.0 0.1 GO:0051299 centrosome separation(GO:0051299)
0.0 0.1 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.1 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.0 GO:0034626 fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.0 0.1 GO:2000758 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.1 GO:0032633 interleukin-4 production(GO:0032633) regulation of interleukin-4 production(GO:0032673)
0.0 0.0 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0 0.0 GO:0060013 righting reflex(GO:0060013)
0.0 0.1 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.0 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0 0.2 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.2 GO:0050766 positive regulation of phagocytosis(GO:0050766)
0.0 0.1 GO:0045350 interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.0 0.0 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.0 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0 0.0 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 0.0 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.0 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)
0.0 0.0 GO:0034139 regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0 0.2 GO:0007032 endosome organization(GO:0007032)
0.0 0.0 GO:1901534 positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0 0.0 GO:0009405 pathogenesis(GO:0009405)
0.0 0.0 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0 0.1 GO:0000729 DNA double-strand break processing(GO:0000729)
0.0 0.0 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.0 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.0 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.0 0.0 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
0.0 0.0 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0 0.0 GO:0016322 neuron remodeling(GO:0016322)
0.0 0.0 GO:0008298 intracellular mRNA localization(GO:0008298)
0.0 0.1 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.1 GO:0032401 establishment of melanosome localization(GO:0032401)
0.0 0.0 GO:0035609 C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0 0.1 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.0 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.0 0.1 GO:0071354 cellular response to interleukin-6(GO:0071354)
0.0 0.0 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.0 GO:0032020 ISG15-protein conjugation(GO:0032020)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.2 GO:0001950 obsolete plasma membrane enriched fraction(GO:0001950)
0.0 0.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.1 GO:0032279 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0 0.1 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0 0.1 GO:0000796 condensin complex(GO:0000796)
0.0 0.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.1 GO:0070761 pre-snoRNP complex(GO:0070761)
0.0 0.1 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)
0.0 0.1 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.0 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.1 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.0 0.1 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0001772 immunological synapse(GO:0001772)
0.0 0.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.0 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.0 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.1 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.1 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.2 GO:0016565 obsolete general transcriptional repressor activity(GO:0016565)
0.0 0.1 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.1 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.1 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.1 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.1 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.1 GO:0000739 obsolete DNA strand annealing activity(GO:0000739)
0.0 0.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.0 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.0 0.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.1 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.1 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 0.0 GO:0019958 C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.0 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.0 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.0 GO:0001846 opsonin binding(GO:0001846)
0.0 0.0 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.0 0.1 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.0 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.1 GO:0015379 potassium:chloride symporter activity(GO:0015379)
0.0 0.0 GO:0045118 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0 0.1 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.2 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.0 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.0 0.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.0 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.0 GO:0004127 cytidylate kinase activity(GO:0004127)
0.0 0.0 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.0 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 0.0 GO:0003720 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 0.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.0 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0051400 BH domain binding(GO:0051400)
0.0 0.0 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0008312 7S RNA binding(GO:0008312)
0.0 0.0 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.0 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.0 0.1 GO:0001784 phosphotyrosine binding(GO:0001784)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.0 PID EPO PATHWAY EPO signaling pathway
0.0 0.1 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.1 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.4 PID AURORA A PATHWAY Aurora A signaling
0.0 0.4 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.6 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.0 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.2 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.0 REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.0 0.0 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.0 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.1 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.1 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.2 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.0 REACTOME INSULIN RECEPTOR SIGNALLING CASCADE Genes involved in Insulin receptor signalling cascade
0.0 0.1 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.1 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.2 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.1 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.1 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.1 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 0.0 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.0 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.0 0.3 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1