Project

ENCODE: H3K4me3 ChIP-Seq of primary human cells

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ETV3

Z-value: 0.40

Motif logo

Transcription factors associated with ETV3

Gene Symbol	Gene ID	Gene Info
ETV3 Ensembl NCBI GeneCards UniProt	ENSG00000117036.7	ETV3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ETV3	chr1_157107163_157108171	492	0.834980	0.87	2.2e-03	Click!
ETV3	chr1_157108332_157108851	325	0.910718	0.72	2.9e-02	Click!
ETV3	chr1_157106972_157107150	1098	0.566512	0.57	1.1e-01	Click!
ETV3	chr1_157133708_157133859	25517	0.204100	0.50	1.7e-01	Click!
ETV3	chr1_157114840_157114991	6649	0.241447	0.49	1.8e-01	Click!

Activity of the ETV3 motif across conditions

Conditions sorted by the z-value of the ETV3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr10_52751128_52751393	0.14	PRKG1	protein kinase, cGMP-dependent, type I	142	0.97
chr16_87850031_87850182	0.13	RP4-536B24.2		20032	0.16
chr6_26026782_26027875	0.12	HIST1H4B	histone cluster 1, H4b	152	0.87
chr20_62339371_62339522	0.09	ZGPAT	zinc finger, CCCH-type with G patch domain	4	0.53
chr15_101675976_101676127	0.09	RP11-505E24.2		49780	0.14
chr2_43447013_43447239	0.09	ZFP36L2	ZFP36 ring finger protein-like 2	6622	0.24
chr8_121457410_121457992	0.09	MTBP	Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa	35	0.54
chr1_224622519_224623397	0.09	WDR26	WD repeat domain 26	957	0.59
chr5_10250012_10250238	0.09	CCT5	chaperonin containing TCP1, subunit 5 (epsilon)	84	0.53
chrX_86773476_86773748	0.08	KLHL4	kelch-like family member 4	795	0.74
chr1_54518261_54518829	0.08	TMEM59	transmembrane protein 59	320	0.67
chr17_13504273_13504480	0.07	HS3ST3A1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	868	0.71
chr3_128879854_128880178	0.07	ISY1	ISY1 splicing factor homolog (S. cerevisiae)	120	0.51
chr6_12483851_12484268	0.07	ENSG00000223321	.	77046	0.12
chr10_6836277_6836922	0.07	PRKCQ	protein kinase C, theta	214336	0.02
chr18_61088602_61089320	0.07	VPS4B	vacuolar protein sorting 4 homolog B (S. cerevisiae)	662	0.7
chr19_16295903_16296067	0.06	FAM32A	family with sequence similarity 32, member A	206	0.9
chr16_90113461_90113700	0.06	URAHP	urate (hydroxyiso-) hydrolase, pseudogene	425	0.76
chr3_51429228_51429432	0.06	RBM15B	RNA binding motif protein 15B	599	0.75
chr4_189329879_189330030	0.06	RP11-366H4.3		265421	0.02
chr19_55896525_55896972	0.06	RPL28	ribosomal protein L28	35	0.9
chr16_4186481_4186632	0.06	ADCY9	adenylate cyclase 9	20370	0.21
chr19_51871127_51871381	0.06	CLDND2	claudin domain containing 2	23	0.92
chr15_44828103_44829028	0.06	EIF3J	eukaryotic translation initiation factor 3, subunit J	690	0.63
chrX_69654840_69655096	0.06	DLG3	discs, large homolog 3 (Drosophila)	9743	0.14
chr11_15096182_15096333	0.06	CALCB	calcitonin-related polypeptide beta	1149	0.59
chr4_171011215_171011473	0.06	AADAT	aminoadipate aminotransferase	21	0.99
chr19_10443271_10443899	0.06	RAVER1	ribonucleoprotein, PTB-binding 1	731	0.41
chr12_45626448_45626744	0.06	ANO6	anoctamin 6	16693	0.28
chr10_121065467_121065729	0.06	RP11-79M19.2		30096	0.16
chr8_27169019_27169417	0.06	PTK2B	protein tyrosine kinase 2 beta	72	0.84
chr19_10305012_10305564	0.06	DNMT1	DNA (cytosine-5-)-methyltransferase 1	14	0.96
chr14_78082774_78083096	0.05	SPTLC2	serine palmitoyltransferase, long chain base subunit 2	181	0.95
chr15_93428286_93428633	0.05	CHD2	chromodomain helicase DNA binding protein 2	1933	0.32
chr8_41142847_41142998	0.05	CTD-3080F16.3		8400	0.16
chr2_238875546_238875758	0.05	UBE2F	ubiquitin-conjugating enzyme E2F (putative)	4	0.98
chr4_26075758_26075909	0.05	RBPJ	recombination signal binding protein for immunoglobulin kappa J region	89244	0.1
chr11_100557988_100558213	0.05	ARHGAP42	Rho GTPase activating protein 42	284	0.73
chr16_3481535_3482301	0.05	ZNF597	zinc finger protein 597	11624	0.11
chr11_44338057_44338887	0.05	ALX4	ALX homeobox 4	6756	0.31
chr2_24270267_24270418	0.05	C2orf44	chromosome 2 open reading frame 44	111	0.92
chr17_79195675_79195980	0.05	AZI1	5-azacytidine induced 1	903	0.39
chr8_28560557_28560810	0.05	EXTL3-AS1	EXTL3 antisense RNA 1	1702	0.31
chr2_119593693_119594050	0.05	EN1	engrailed homeobox 1	11383	0.28
chr17_43250076_43250792	0.05	RP13-890H12.2		1483	0.24
chr8_124693209_124693578	0.05	KLHL38	kelch-like family member 38	28203	0.16
chr15_77713058_77713524	0.05	HMG20A	high mobility group 20A	28	0.95
chr19_55791240_55791709	0.05	HSPBP1	HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1	5	0.94
chr16_8972178_8972329	0.05	RP11-77H9.6		9145	0.13
chr10_43249759_43250194	0.05	BMS1	BMS1 ribosome biogenesis factor	28273	0.19
chr1_92952215_92952548	0.05	GFI1	growth factor independent 1 transcription repressor	52	0.98
chr7_74572135_74572677	0.05	GTF2IRD2B	GTF2I repeat domain containing 2B	15502	0.24
chr6_153323257_153323895	0.05	MTRF1L	mitochondrial translational release factor 1-like	244	0.91
chr13_21287965_21288116	0.05	ENSG00000265710	.	10198	0.19
chr7_154795580_154795843	0.05	PAXIP1	PAX interacting (with transcription-activation domain) protein 1	917	0.58
chr7_100861322_100861626	0.05	PLOD3	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	199	0.75
chr12_133613669_133614058	0.05	ZNF84	zinc finger protein 84	15	0.97
chr17_7387752_7387955	0.04	POLR2A	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	86	0.71
chr12_42877069_42877413	0.04	PRICKLE1	prickle homolog 1 (Drosophila)	175	0.94
chrX_152200749_152200932	0.04	PNMA3	paraneoplastic Ma antigen 3	23926	0.12
chr1_233249017_233249707	0.04	PCNXL2	pecanex-like 2 (Drosophila)	46691	0.19
chr2_11989597_11989775	0.04	ENSG00000265172	.	12574	0.22
chr1_247275087_247275577	0.04	C1orf229	chromosome 1 open reading frame 229	387	0.83
chr17_71301523_71301822	0.04	CDC42EP4	CDC42 effector protein (Rho GTPase binding) 4	5875	0.2
chr1_19407511_19408053	0.04	UBR4	ubiquitin protein ligase E3 component n-recognin 4	952	0.54
chr11_60673508_60673995	0.04	PRPF19	pre-mRNA processing factor 19	262	0.64
chr19_45393848_45394047	0.04	TOMM40	translocase of outer mitochondrial membrane 40 homolog (yeast)	121	0.58
chr14_102414684_102415292	0.04	DYNC1H1	dynein, cytoplasmic 1, heavy chain 1	15877	0.19
chr22_21367894_21368045	0.04	P2RX6	purinergic receptor P2X, ligand-gated ion channel, 6	1347	0.2
chr10_30509279_30509508	0.04	ENSG00000200887	.	79209	0.09
chr22_27068598_27068749	0.04	CRYBA4	crystallin, beta A4	50745	0.13
chr20_52517333_52517726	0.04	AC005220.3		39170	0.2
chr5_141404364_141404742	0.04	GNPDA1	glucosamine-6-phosphate deaminase 1	11947	0.17
chr8_97274172_97274393	0.04	PTDSS1	phosphatidylserine synthase 1	141	0.8
chr9_127622518_127622669	0.04	RPL35	ribosomal protein L35	1601	0.24
chr1_10864488_10864639	0.04	CASZ1	castor zinc finger 1	7856	0.26
chr3_126206096_126206282	0.04	ZXDC	ZXD family zinc finger C	11427	0.16
chr12_6798903_6799301	0.04	ZNF384	zinc finger protein 384	426	0.65
chr1_43637945_43638198	0.04	WDR65	WD repeat domain 65	56	0.61
chr19_39322550_39322701	0.04	ECH1	enoyl CoA hydratase 1, peroxisomal	20	0.94
chr21_39228435_39228586	0.03	KCNJ6	potassium inwardly-rectifying channel, subfamily J, member 6	57047	0.14
chr3_93781580_93781765	0.03	NSUN3	NOP2/Sun domain family, member 3	88	0.6
chr4_173708323_173708474	0.03	ENSG00000241652	.	354396	0.01
chr1_17914072_17914223	0.03	ARHGEF10L	Rho guanine nucleotide exchange factor (GEF) 10-like	764	0.76
chr3_28390250_28390542	0.03	AZI2	5-azacytidine induced 2	19	0.77
chr14_24701887_24702567	0.03	GMPR2	guanosine monophosphate reductase 2	73	0.8
chr19_58892078_58892419	0.03	ZNF837	zinc finger protein 837	141	0.87
chr3_88198857_88199168	0.03	CGGBP1	CGG triplet repeat binding protein 1	23	0.61
chr11_118122819_118123419	0.03	MPZL3	myelin protein zero-like 3	54	0.96
chr19_51014448_51014741	0.03	JOSD2	Josephin domain containing 2	16	0.95
chr5_173334437_173334588	0.03	CPEB4	cytoplasmic polyadenylation element binding protein 4	14431	0.25
chr11_134094076_134094379	0.03	NCAPD3	non-SMC condensin II complex, subunit D3	199	0.63
chr9_971958_972221	0.03	DMRT3	doublesex and mab-3 related transcription factor 3	4875	0.26
chr1_32479424_32479717	0.03	KHDRBS1	KH domain containing, RNA binding, signal transduction associated 1	27	0.97
chr12_51566615_51566911	0.03	TFCP2	transcription factor CP2	68	0.96
chr19_58570193_58570626	0.03	ZNF135	zinc finger protein 135	198	0.9
chr12_49961755_49962069	0.03	MCRS1	microspherule protein 1	2	0.76
chr10_88125065_88125216	0.03	GRID1	glutamate receptor, ionotropic, delta 1	1095	0.59
chr6_144164528_144165302	0.03	LTV1	LTV1 homolog (S. cerevisiae)	434	0.87
chr17_34599013_34599342	0.03	TBC1D3C	TBC1 domain family, member 3C	7145	0.15
chr14_21978616_21979591	0.03	METTL3	methyltransferase like 3	379	0.78
chr4_140216949_140217285	0.03	NDUFC1	NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa	160	0.93
chr8_122515301_122515452	0.03	ENSG00000263525	.	39859	0.21
chr1_155147010_155147208	0.03	TRIM46	tripartite motif containing 46	666	0.35
chr10_43932295_43932516	0.03	ZNF487	zinc finger protein 487	116	0.96
chr19_11616618_11616769	0.03	ZNF653	zinc finger protein 653	45	0.95
chr3_195946092_195946608	0.03	SLC51A	solute carrier family 51, alpha subunit	1587	0.28
chr9_136776234_136776385	0.03	VAV2	vav 2 guanine nucleotide exchange factor	81094	0.08
chr7_108209550_108210056	0.03	THAP5	THAP domain containing 5	94	0.67
chr10_75504089_75504991	0.03	SEC24C	SEC24 family member C	382	0.7
chr1_100231847_100232213	0.03	FRRS1	ferric-chelate reductase 1	681	0.67
chr15_78592072_78592304	0.03	WDR61	WD repeat domain 61	52	0.96
chr12_72080266_72080710	0.03	TMEM19	transmembrane protein 19	212	0.93
chr9_127174465_127174742	0.03	PSMB7	proteasome (prosome, macropain) subunit, beta type, 7	3115	0.26
chr19_37263819_37264017	0.03	CTD-2162K18.4	Uncharacterized protein	137	0.57
chr3_184033030_184033497	0.03	EIF4G1	eukaryotic translation initiation factor 4 gamma, 1	67	0.94
chr12_49109524_49110644	0.03	CCNT1	cyclin T1	597	0.6
chr13_110993415_110993566	0.03	COL4A2	collagen, type IV, alpha 2	33876	0.17
chr5_139724897_139725179	0.03	HBEGF	heparin-binding EGF-like growth factor	1150	0.36
chr6_86303657_86304481	0.03	SNX14	sorting nexin 14	195	0.95
chr2_27028844_27028995	0.03	CENPA	centromere protein A	19983	0.16
chr8_6264551_6264771	0.03	RP11-115C21.2		2	0.91
chr8_55013175_55014052	0.03	LYPLA1	lysophospholipase I	482	0.83
chr12_6649814_6649965	0.03	RP5-940J5.9		2353	0.11
chr18_8750784_8750935	0.03	ENSG00000252319	.	30729	0.14
chrX_51545867_51547149	0.03	MAGED1	melanoma antigen family D, 1	405	0.89
chr1_240783288_240783439	0.03	GREM2	gremlin 2, DAN family BMP antagonist	7914	0.2
chr12_58138857_58139538	0.03	TSPAN31	tetraspanin 31	32	0.92
chr16_31008287_31008527	0.03	STX1B	syntaxin 1B	3869	0.1
chr15_43663331_43663561	0.03	TUBGCP4	tubulin, gamma complex associated protein 4	133	0.62
chr7_41426318_41426600	0.03	INHBA-AS1	INHBA antisense RNA 1	307055	0.01
chr13_106571784_106572046	0.03	ENSG00000252550	.	21923	0.28
chr16_16043073_16043272	0.03	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	262	0.93
chr17_37301005_37301156	0.03	PLXDC1	plexin domain containing 1	6822	0.14
chr2_32502679_32502951	0.03	YIPF4	Yip1 domain family, member 4	164	0.95
chr9_124048192_124048723	0.03	GSN	gelsolin	413	0.59
chr2_43822335_43823890	0.03	THADA	thyroid adenoma associated	1	0.98
chr6_27584810_27585278	0.03	ENSG00000238648	.	14144	0.19
chr14_65381486_65381648	0.03	CHURC1-FNTB	CHURC1-FNTB readthrough	356	0.32
chr8_94766637_94767113	0.03	TMEM67	transmembrane protein 67	197	0.9
chr3_28390062_28390213	0.02	AZI2	5-azacytidine induced 2	17	0.91
chr16_27378896_27379134	0.02	IL4R	interleukin 4 receptor	15019	0.19
chr3_45165734_45165944	0.02	CDCP1	CUB domain containing protein 1	22075	0.2
chr9_132382165_132382732	0.02	C9orf50	chromosome 9 open reading frame 50	607	0.62
chr7_99006283_99006480	0.02	PDAP1	PDGFA associated protein 1	71	0.55
chr2_208675899_208676134	0.02	FZD5	frizzled family receptor 5	41729	0.12
chr11_61892028_61892235	0.02	INCENP	inner centromere protein antigens 135/155kDa	661	0.71
chr19_35940283_35940434	0.02	FFAR2	free fatty acid receptor 2	259	0.87
chr1_20987073_20987907	0.02	DDOST	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)	391	0.83
chr1_148556730_148556881	0.02	NBPF15	neuroblastoma breakpoint family, member 15	4038	0.3
chr3_42844965_42845933	0.02	HIGD1A	HIG1 hypoxia inducible domain family, member 1A	476	0.69
chr3_37901503_37901845	0.02	ENSG00000235257	.	1537	0.34
chr1_220906357_220906642	0.02	MARC2	mitochondrial amidoxime reducing component 2	15112	0.19
chr8_102120904_102121301	0.02	ENSG00000202360	.	29085	0.21
chr18_3248652_3249060	0.02	MYL12A	myosin, light chain 12A, regulatory, non-sarcomeric	985	0.49
chr7_42896707_42897080	0.02	C7orf25	chromosome 7 open reading frame 25	54616	0.14
chr1_33593144_33593416	0.02	ADC	arginine decarboxylase	45429	0.12
chr12_14923072_14924123	0.02	HIST4H4	histone cluster 4, H4	468	0.69
chr17_34510955_34511411	0.02	AC131056.3		342	0.79
chr1_33772863_33773014	0.02	RP11-415J8.3		29	0.96
chrX_146993330_146993481	0.02	FMR1	fragile X mental retardation 1	64	0.5
chr11_130183263_130184165	0.02	ZBTB44	zinc finger and BTB domain containing 44	772	0.68
chr5_150163315_150163466	0.02	AC010441.1		5523	0.16
chr11_57408298_57408449	0.02	ENSG00000208009	.	298	0.8
chr19_40596081_40597156	0.02	AC005614.3		43	0.64
chr1_169764110_169764261	0.02	C1orf112	chromosome 1 open reading frame 112	4	0.55
chr15_62682825_62683674	0.02	RP11-299H22.5		120370	0.05
chr11_809579_809818	0.02	RPLP2	ribosomal protein, large, P2	51	0.91
chr17_65362498_65362713	0.02	PSMD12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12	116	0.96
chr2_198063557_198063736	0.02	ANKRD44	ankyrin repeat domain 44	884	0.43
chr5_72599487_72599638	0.02	TMEM174	transmembrane protein 174	130540	0.04
chr15_57998770_57998921	0.02	POLR2M	polymerase (RNA) II (DNA directed) polypeptide M	18	0.99
chr1_180881031_180881376	0.02	KIAA1614	KIAA1614	1122	0.51
chr2_163174641_163175537	0.02	IFIH1	interferon induced with helicase C domain 1	105	0.76
chr15_25684395_25684621	0.02	UBE3A	ubiquitin protein ligase E3A	380	0.82
chrX_40976244_40976504	0.02	USP9X	ubiquitin specific peptidase 9, X-linked	31486	0.22
chr20_388999_389747	0.02	RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	386	0.82
chr1_216773992_216774229	0.02	ESRRG	estrogen-related receptor gamma	122564	0.06
chr12_46385346_46385747	0.02	SCAF11	SR-related CTD-associated factor 11	357	0.93
chr12_88178270_88178421	0.02	C12orf50	chromosome 12 open reading frame 50	243395	0.02
chr20_30326525_30327002	0.02	TPX2	TPX2, microtubule-associated	311	0.86
chrX_48754632_48755057	0.02	TIMM17B	translocase of inner mitochondrial membrane 17 homolog B (yeast)	186	0.66
chr15_66906109_66906400	0.02	RP11-321F6.1	HCG2003567; Uncharacterized protein	31726	0.13
chr10_116755612_116755763	0.02	ENSG00000252611	.	26360	0.22
chr17_25623130_25623281	0.02	WSB1	WD repeat and SOCS box containing 1	1833	0.35
chr15_76442977_76443390	0.02	RP11-593F23.1		30644	0.19
chr3_81545158_81545309	0.02	ENSG00000222389	.	13394	0.32
chr10_131761561_131761767	0.02	EBF3	early B-cell factor 3	441	0.9
chr19_44331131_44331711	0.02	ZNF283	zinc finger protein 283	23	0.53
chr5_174151065_174151298	0.02	MSX2	msh homeobox 2	355	0.92
chr6_50784871_50785022	0.02	TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	1490	0.57
chr8_144416622_144416994	0.02	TOP1MT	topoisomerase (DNA) I, mitochondrial	157	0.91
chr12_118745072_118745584	0.02	TAOK3	TAO kinase 3	51464	0.15
chr2_242576780_242577011	0.02	THAP4	THAP domain containing 4	31	0.62
chr12_101673896_101674669	0.02	UTP20	UTP20, small subunit (SSU) processome component, homolog (yeast)	395	0.87
chr18_74271433_74271584	0.02	LINC00908	long intergenic non-protein coding RNA 908	30634	0.18
chr7_5862773_5862988	0.02	ZNF815P	zinc finger protein 815, pseudogene	42	0.97
chr4_81189966_81190509	0.02	FGF5	fibroblast growth factor 5	2444	0.36
chr5_173145147_173145298	0.02	ENSG00000263401	.	11859	0.27
chr21_45209367_45209684	0.02	RRP1	ribosomal RNA processing 1	131	0.95

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ETV3

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Total log-likelihood	Term	Description
0.1	GO:0051571	positive regulation of histone H3-K4 methylation(GO:0051571)
0.1	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.1	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.1	GO:0017059	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.1	GO:0005721	pericentric heterochromatin(GO:0005721)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.1	GO:0036137	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.1	GO:0016454	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1	GO:0004690	cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	GO:0019788	NEDD8 transferase activity(GO:0019788)