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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ETV4_ETS2

Z-value: 0.73

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Transcription factors associated with ETV4_ETS2

Gene Symbol	Gene ID	Gene Info
ETV4 Ensembl NCBI GeneCards UniProt	ENSG00000175832.8	ETV4
ETS2 Ensembl NCBI GeneCards UniProt	ENSG00000157557.7	ETS2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ETS2	chr21_40145836_40145987	31320	0.225744	-0.63	7.0e-02	Click!
ETS2	chr21_40123884_40124035	53272	0.157989	0.62	7.4e-02	Click!
ETS2	chr21_40211978_40212129	30493	0.211955	-0.58	1.0e-01	Click!
ETS2	chr21_40145573_40145724	31583	0.224902	-0.57	1.1e-01	Click!
ETS2	chr21_40138917_40139228	38159	0.203751	0.54	1.3e-01	Click!
ETV4	chr17_41623926_41624196	261	0.873284	-0.85	3.7e-03	Click!
ETV4	chr17_41622914_41623315	33	0.946190	-0.82	6.6e-03	Click!
ETV4	chr17_41669450_41669625	12549	0.163785	-0.77	1.6e-02	Click!
ETV4	chr17_41668751_41668949	11862	0.164855	-0.77	1.6e-02	Click!
ETV4	chr17_41669802_41669953	12889	0.163264	-0.75	2.0e-02	Click!

Activity of the ETV4_ETS2 motif across conditions

Conditions sorted by the z-value of the ETV4_ETS2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_63974616_63975431	0.24	FERMT3	fermitin family member 3	266	0.78
chr12_51714745_51715007	0.24	BIN2	bridging integrator 2	3023	0.21
chr9_95857151_95857367	0.23	RP11-274J16.5		552	0.64
chr9_95726568_95726886	0.23	FGD3	FYVE, RhoGEF and PH domain containing 3	484	0.84
chr11_65407442_65407916	0.21	SIPA1	signal-induced proliferation-associated 1	87	0.92
chr10_73531555_73531706	0.21	C10orf54	chromosome 10 open reading frame 54	1625	0.38
chr4_2800484_2801318	0.20	SH3BP2	SH3-domain binding protein 2	176	0.95
chr22_50319474_50319638	0.19	CRELD2	cysteine-rich with EGF-like domains 2	7175	0.17
chr1_245215310_245215673	0.19	ENSG00000251754	.	8261	0.17
chr17_29814991_29815971	0.18	RAB11FIP4	RAB11 family interacting protein 4 (class II)	355	0.83
chr17_7239932_7240900	0.18	ACAP1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	507	0.51
chr1_167586551_167586989	0.18	RCSD1	RCSD domain containing 1	12560	0.19
chr10_75624935_75625135	0.18	CAMK2G	calcium/calmodulin-dependent protein kinase II gamma	4423	0.13
chr14_101587281_101587508	0.18	ENSG00000206761	.	24638	0.04
chr13_46752366_46752713	0.18	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	3920	0.19
chrX_129225814_129226276	0.17	ELF4	E74-like factor 4 (ets domain transcription factor)	18291	0.19
chr17_4618141_4618477	0.16	ARRB2	arrestin, beta 2	575	0.53
chr19_1067222_1068216	0.16	HMHA1	histocompatibility (minor) HA-1	222	0.85
chr20_62708665_62709256	0.16	RGS19	regulator of G-protein signaling 19	1885	0.17
chr3_13050979_13051187	0.16	IQSEC1	IQ motif and Sec7 domain 1	22547	0.24
chr1_79111525_79111735	0.16	IFI44	interferon-induced protein 44	3886	0.26
chr13_99195211_99195547	0.16	STK24	serine/threonine kinase 24	21127	0.2
chr19_49839028_49839359	0.16	CD37	CD37 molecule	472	0.63
chr1_160676943_160677601	0.15	CD48	CD48 molecule	4321	0.18
chr3_52279791_52280791	0.15	PPM1M	protein phosphatase, Mg2+/Mn2+ dependent, 1M	66	0.94
chr11_128587302_128587453	0.15	SENCR	smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA	21459	0.17
chr17_66344269_66344555	0.15	ARSG	arylsulfatase G	56753	0.1
chr7_100484820_100485063	0.15	SRRT	serrate RNA effector molecule homolog (Arabidopsis)	383	0.71
chr10_126300385_126300576	0.15	FAM53B-AS1	FAM53B antisense RNA 1	91714	0.07
chr15_102182223_102182374	0.15	ENSG00000252614	.	6217	0.18
chr1_27945148_27945299	0.15	FGR	feline Gardner-Rasheed sarcoma viral oncogene homolog	5350	0.15
chr11_60932018_60932169	0.14	VPS37C	vacuolar protein sorting 37 homolog C (S. cerevisiae)	3004	0.22
chr19_55084758_55085279	0.14	LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	200	0.63
chr10_11212951_11213685	0.14	RP3-323N1.2		21	0.98
chr11_6251374_6251525	0.14	FAM160A2	family with sequence similarity 160, member A2	4397	0.13
chr1_206732541_206732911	0.14	RASSF5	Ras association (RalGDS/AF-6) domain family member 5	2233	0.27
chr12_54866933_54867431	0.14	GTSF1	gametocyte specific factor 1	201	0.92
chr2_106392629_106392859	0.14	NCK2	NCK adaptor protein 2	30556	0.23
chr2_175498105_175498391	0.14	WIPF1	WAS/WASL interacting protein family, member 1	1059	0.58
chr6_144980278_144980429	0.13	UTRN	utrophin	627	0.85
chr7_150329208_150329551	0.13	GIMAP6	GTPase, IMAP family member 6	55	0.98
chr7_50727890_50728167	0.13	GRB10	growth factor receptor-bound protein 10	33401	0.21
chr18_74836287_74836734	0.13	MBP	myelin basic protein	3158	0.38
chr19_1895348_1895705	0.13	SCAMP4	secretory carrier membrane protein 4	9687	0.09
chr17_38478388_38479657	0.13	RARA	retinoic acid receptor, alpha	4485	0.13
chr7_63361181_63361806	0.13	ENSG00000263891	.	47	0.98
chr8_125210334_125210485	0.13	FER1L6-AS2	FER1L6 antisense RNA 2	26646	0.21
chr8_144328075_144328422	0.13	ZFP41	ZFP41 zinc finger protein	743	0.53
chr8_97324979_97325228	0.13	ENSG00000199732	.	3553	0.24
chr10_94590680_94591107	0.13	EXOC6	exocyst complex component 6	42	0.99
chr16_29674660_29674967	0.13	QPRT	quinolinate phosphoribosyltransferase	213	0.51
chr16_17542920_17543071	0.13	XYLT1	xylosyltransferase I	21743	0.29
chr14_101034010_101035263	0.12	BEGAIN	brain-enriched guanylate kinase-associated	192	0.93
chr9_117145588_117145751	0.12	AKNA	AT-hook transcription factor	4574	0.23
chr10_7526759_7527322	0.12	ENSG00000207453	.	1731	0.45
chr8_145086794_145086945	0.12	PARP10	poly (ADP-ribose) polymerase family, member 10	71	0.74
chr13_46752006_46752233	0.12	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	4340	0.19
chr6_111180837_111181007	0.12	ENSG00000199360	.	3302	0.2
chr6_32160504_32160787	0.12	GPSM3	G-protein signaling modulator 3	0	0.94
chr2_220113848_220114166	0.12	STK16	serine/threonine kinase 16	3389	0.09
chr16_79123602_79124194	0.12	RP11-556H2.3		49	0.98
chr16_29756670_29756842	0.12	AC009133.17		188	0.77
chr21_15914339_15914644	0.12	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	4171	0.29
chr5_14594534_14594878	0.12	FAM105A	family with sequence similarity 105, member A	12822	0.24
chr10_11187446_11187644	0.12	CELF2	CUGBP, Elav-like family member 2	19448	0.19
chr11_47396682_47396833	0.12	SPI1	spleen focus forming virus (SFFV) proviral integration oncogene	3185	0.13
chr1_203734376_203734572	0.12	LAX1	lymphocyte transmembrane adaptor 1	169	0.94
chr6_166747166_166747317	0.11	SFT2D1	SFT2 domain containing 1	8838	0.19
chr20_34078435_34078749	0.11	RP3-477O4.14		151	0.92
chr1_28213912_28214063	0.11	THEMIS2	thymocyte selection associated family member 2	7745	0.12
chr20_57465496_57466112	0.11	GNAS	GNAS complex locus	553	0.66
chr9_134150778_134151758	0.11	FAM78A	family with sequence similarity 78, member A	666	0.69
chr4_26263054_26263205	0.11	RBPJ	recombination signal binding protein for immunoglobulin kappa J region	11100	0.31
chr3_111851637_111852199	0.11	GCSAM	germinal center-associated, signaling and motility	154	0.73
chr4_1287250_1287401	0.11	MAEA	macrophage erythroblast attacher	3642	0.18
chr2_175357999_175358525	0.11	GPR155	G protein-coupled receptor 155	6440	0.21
chr5_150594214_150594453	0.11	GM2A	GM2 ganglioside activator	2622	0.27
chr5_544016_544540	0.11	ENSG00000264233	.	8281	0.14
chr19_49859286_49859437	0.11	AC010524.4		48	0.94
chr1_26616865_26617016	0.11	SH3BGRL3	SH3 domain binding glutamic acid-rich protein like 3	10327	0.11
chr19_13206703_13207270	0.11	LYL1	lymphoblastic leukemia derived sequence 1	6695	0.11
chr1_198648918_198649184	0.11	RP11-553K8.5		12861	0.25
chr9_95532616_95532767	0.11	BICD2	bicaudal D homolog 2 (Drosophila)	5597	0.21
chr20_47377126_47377429	0.11	ENSG00000251876	.	21292	0.24
chr17_2697553_2697769	0.11	RAP1GAP2	RAP1 GTPase activating protein 2	2071	0.29
chr9_126628860_126629011	0.11	DENND1A	DENN/MADD domain containing 1A	63451	0.12
chr19_35645615_35646695	0.11	FXYD5	FXYD domain containing ion transport regulator 5	310	0.8
chr19_10715319_10715578	0.11	SLC44A2	solute carrier family 44 (choline transporter), member 2	2262	0.17
chrX_117832511_117832662	0.11	IL13RA1	interleukin 13 receptor, alpha 1	28949	0.19
chr17_34603649_34603800	0.10	TBC1D3C	TBC1 domain family, member 3C	11692	0.14
chr19_42210710_42210868	0.10	CEACAM5	carcinoembryonic antigen-related cell adhesion molecule 5	1715	0.23
chr1_36042987_36043882	0.10	RP4-728D4.2		104	0.95
chrX_70328757_70329094	0.10	IL2RG	interleukin 2 receptor, gamma	193	0.89
chr11_117841514_117841665	0.10	IL10RA	interleukin 10 receptor, alpha	15474	0.17
chr9_95787859_95788010	0.10	FGD3	FYVE, RhoGEF and PH domain containing 3	10592	0.19
chr6_106611529_106611909	0.10	RP1-134E15.3		63704	0.11
chr11_1874347_1875032	0.10	LSP1	lymphocyte-specific protein 1	489	0.65
chr9_117146231_117146573	0.10	AKNA	AT-hook transcription factor	3841	0.25
chr19_48747671_48748205	0.10	CARD8	caspase recruitment domain family, member 8	3618	0.15
chr5_172272383_172272534	0.10	ERGIC1	endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1	11044	0.19
chr22_27067492_27067685	0.10	CRYBA4	crystallin, beta A4	49660	0.13
chr5_148620092_148620243	0.10	ABLIM3	actin binding LIM protein family, member 3	2744	0.22
chr5_176882439_176883305	0.10	DBN1	drebrin 1	6518	0.1
chr6_41168130_41168571	0.10	TREML2	triggering receptor expressed on myeloid cells-like 2	582	0.65
chr4_148713676_148713874	0.10	ENSG00000264274	.	10029	0.19
chrX_39949292_39950247	0.10	BCOR	BCL6 corepressor	6887	0.33
chr7_119172_119323	0.10	FAM20C	family with sequence similarity 20, member C	73722	0.11
chr1_2480724_2480985	0.10	TNFRSF14	tumor necrosis factor receptor superfamily, member 14	6224	0.1
chr7_73625229_73625469	0.10	LAT2	linker for activation of T cells family, member 2	996	0.49
chr2_242556723_242557374	0.10	THAP4	THAP domain containing 4	132	0.94
chr6_14857980_14858173	0.10	ENSG00000206960	.	211310	0.02
chr15_40598587_40598738	0.10	PLCB2	phospholipase C, beta 2	1364	0.23
chr20_37434091_37434759	0.10	PPP1R16B	protein phosphatase 1, regulatory subunit 16B	58	0.98
chr10_79362617_79362768	0.10	ENSG00000199592	.	15885	0.23
chr19_50400390_50400724	0.09	IL4I1	interleukin 4 induced 1	345	0.67
chr5_95159606_95160004	0.09	GLRX	glutaredoxin (thioltransferase)	1096	0.44
chr20_23063904_23064055	0.09	CD93	CD93 molecule	2998	0.23
chr2_112913175_112913326	0.09	FBLN7	fibulin 7	4075	0.29
chr7_6065805_6065956	0.09	EIF2AK1	eukaryotic translation initiation factor 2-alpha kinase 1	303	0.79
chr16_30915229_30915507	0.09	CTF1	cardiotrophin 1	7409	0.08
chr3_13455515_13455928	0.09	NUP210	nucleoporin 210kDa	6088	0.26
chr1_11800239_11800390	0.09	AGTRAP	angiotensin II receptor-associated protein	4082	0.15
chr17_34617167_34617318	0.09	CCL3L1	chemokine (C-C motif) ligand 3-like 1	8477	0.15
chr3_53201143_53201294	0.09	PRKCD	protein kinase C, delta	2073	0.29
chr1_153363293_153363489	0.09	S100A8	S100 calcium binding protein A8	61	0.95
chr13_99930587_99930738	0.09	GPR18	G protein-coupled receptor 18	16664	0.18
chr22_37637445_37637596	0.09	RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	2768	0.2
chr2_69062344_69062572	0.09	AC097495.2		322	0.9
chr11_122587919_122588091	0.09	ENSG00000239079	.	9014	0.25
chr13_25855828_25855979	0.09	MTMR6	myotubularin related protein 6	5801	0.2
chr7_36325944_36326095	0.09	EEPD1	endonuclease/exonuclease/phosphatase family domain containing 1	10734	0.18
chr5_131810697_131810848	0.09	AC116366.6		2037	0.23
chr2_8612888_8613039	0.09	AC011747.7		202933	0.03
chr2_232573344_232574118	0.09	PTMA	prothymosin, alpha	485	0.75
chr8_59506492_59506643	0.09	SDCBP	syndecan binding protein (syntenin)	28992	0.19
chr17_72459969_72460120	0.09	CD300A	CD300a molecule	2511	0.22
chr14_51280333_51280548	0.09	RP11-286O18.1		8158	0.15
chr19_51631094_51631245	0.09	SIGLEC9	sialic acid binding Ig-like lectin 9	882	0.38
chr5_175123540_175123739	0.09	ENSG00000200648	.	7262	0.21
chr11_67176589_67176876	0.09	TBC1D10C	TBC1 domain family, member 10C	5072	0.07
chr13_33607800_33607951	0.09	ENSG00000221677	.	7614	0.24
chr12_15104428_15104579	0.09	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	418	0.81
chr15_99192776_99194432	0.09	IGF1R	insulin-like growth factor 1 receptor	1331	0.47
chr10_134365004_134365155	0.09	INPP5A	inositol polyphosphate-5-phosphatase, 40kDa	13436	0.21
chr6_36666192_36666416	0.09	RAB44	RAB44, member RAS oncogene family	16952	0.13
chr2_169961988_169962139	0.09	AC007556.3		4810	0.25
chr9_102587867_102588202	0.09	NR4A3	nuclear receptor subfamily 4, group A, member 3	975	0.66
chr19_10982465_10983821	0.09	CARM1	coactivator-associated arginine methyltransferase 1	764	0.53
chr21_36900755_36901002	0.09	ENSG00000211590	.	192135	0.03
chr8_125208186_125208337	0.09	FER1L6-AS2	FER1L6 antisense RNA 2	24498	0.22
chr1_203254106_203254257	0.09	BTG2	BTG family, member 2	20483	0.15
chr9_117149358_117150269	0.09	AKNA	AT-hook transcription factor	430	0.85
chr2_149303870_149304072	0.09	MBD5	methyl-CpG binding domain protein 5	77677	0.11
chr15_69961298_69961449	0.09	ENSG00000238870	.	61788	0.13
chr5_131793340_131793491	0.09	ENSG00000202533	.	10424	0.13
chr15_40659564_40659826	0.09	RP11-64K12.4		2146	0.13
chr17_75437754_75438017	0.09	ENSG00000200651	.	306	0.87
chr9_120477806_120477957	0.09	ENSG00000201444	.	7501	0.21
chr4_169427075_169427226	0.09	PALLD	palladin, cytoskeletal associated protein	5569	0.22
chr6_143177934_143178085	0.09	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	19825	0.26
chr20_19055744_19055895	0.09	ENSG00000264669	.	50610	0.16
chr6_35279100_35279566	0.09	DEF6	differentially expressed in FDCP 6 homolog (mouse)	1818	0.34
chr7_158505123_158505274	0.09	NCAPG2	non-SMC condensin II complex, subunit G2	7678	0.23
chr3_71493443_71493594	0.09	ENSG00000221264	.	97722	0.08
chr19_30171358_30171509	0.08	PLEKHF1	pleckstrin homology domain containing, family F (with FYVE domain) member 1	13652	0.21
chr1_204482334_204482501	0.08	MDM4	Mdm4 p53 binding protein homolog (mouse)	3094	0.23
chr17_27220072_27220391	0.08	RP11-20B24.7		744	0.4
chr7_106505707_106506635	0.08	PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	247	0.95
chr21_48042285_48042436	0.08	PRMT2	protein arginine methyltransferase 2	12719	0.2
chr7_137620698_137620944	0.08	CREB3L2	cAMP responsive element binding protein 3-like 2	2185	0.34
chr9_101881133_101881552	0.08	TGFBR1	transforming growth factor, beta receptor 1	8715	0.21
chrX_17848143_17848294	0.08	RAI2	retinoic acid induced 2	7632	0.3
chr7_138757613_138757764	0.08	ZC3HAV1	zinc finger CCCH-type, antiviral 1	6325	0.22
chr6_13636625_13636776	0.08	AL441883.1	Uncharacterized protein	15574	0.14
chr5_156696070_156696221	0.08	CYFIP2	cytoplasmic FMR1 interacting protein 2	217	0.91
chr8_30514582_30515646	0.08	GTF2E2	general transcription factor IIE, polypeptide 2, beta 34kDa	21	0.98
chr7_2684869_2685165	0.08	TTYH3	tweety family member 3	149	0.96
chr10_112619332_112619483	0.08	PDCD4	programmed cell death 4 (neoplastic transformation inhibitor)	12158	0.14
chr7_26415747_26416790	0.08	AC004540.4		53	0.98
chr8_102150052_102150203	0.08	ENSG00000202360	.	60	0.98
chr10_70804041_70804192	0.08	SRGN	serglycin	43758	0.12
chr7_148844568_148845756	0.08	ZNF398	zinc finger protein 398	57	0.97
chrX_38676446_38676597	0.08	MID1IP1-AS1	MID1IP1 antisense RNA 1	13385	0.23
chr11_64510621_64511071	0.08	RASGRP2	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	415	0.76
chr9_139117966_139118117	0.08	QSOX2	quiescin Q6 sulfhydryl oxidase 2	1318	0.43
chr5_175665565_175666307	0.08	SIMC1	SUMO-interacting motifs containing 1	533	0.81
chr2_70171863_70172014	0.08	ENSG00000239072	.	10839	0.12
chr11_75479321_75480435	0.08	DGAT2	diacylglycerol O-acyltransferase 2	21	0.69
chr9_117690313_117690616	0.08	TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	2233	0.42
chr10_27148230_27149879	0.08	ABI1	abl-interactor 1	738	0.67
chr11_64546452_64546665	0.08	SF1	splicing factor 1	300	0.83
chr1_8285162_8285313	0.08	ENSG00000200975	.	18580	0.19
chr1_6524907_6525205	0.08	TNFRSF25	tumor necrosis factor receptor superfamily, member 25	634	0.58
chr11_64107746_64107914	0.08	CCDC88B	coiled-coil domain containing 88B	135	0.9
chr18_9095215_9095557	0.08	NDUFV2	NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa	7242	0.18
chr11_133826464_133827261	0.08	IGSF9B	immunoglobulin superfamily, member 9B	18	0.58
chr5_40616837_40616988	0.08	ENSG00000199552	.	38153	0.18
chr1_2509263_2509520	0.08	RP3-395M20.9		3608	0.12
chr17_81147720_81147871	0.08	METRNL	meteorin, glial cell differentiation regulator-like	95801	0.08
chr8_28918241_28918392	0.08	CTD-2647L4.4		4864	0.16

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ETV4_ETS2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0033622	integrin activation(GO:0033622)
0.1	0.3	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.1	GO:0070340	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.1	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.1	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.1	GO:0031053	primary miRNA processing(GO:0031053)
0.0	0.1	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.1	GO:0002864	regulation of acute inflammatory response to antigenic stimulus(GO:0002864)
0.0	0.1	GO:0042816	pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0	0.1	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.0	0.1	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.1	GO:0032656	regulation of interleukin-13 production(GO:0032656)
0.0	0.1	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.0	GO:0002361	CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0	0.1	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.1	GO:0032928	regulation of superoxide anion generation(GO:0032928)
0.0	0.1	GO:0030644	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.0	GO:0002863	positive regulation of inflammatory response to antigenic stimulus(GO:0002863)
0.0	0.1	GO:0072385	minus-end-directed organelle transport along microtubule(GO:0072385)
0.0	0.1	GO:0009405	pathogenesis(GO:0009405)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.1	GO:0061072	iris morphogenesis(GO:0061072)
0.0	0.1	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	0.0	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.1	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.1	GO:0002517	T cell tolerance induction(GO:0002517) regulation of T cell tolerance induction(GO:0002664) positive regulation of T cell tolerance induction(GO:0002666)
0.0	0.1	GO:0048752	semicircular canal morphogenesis(GO:0048752)
0.0	0.1	GO:0071360	cellular response to exogenous dsRNA(GO:0071360)
0.0	0.0	GO:0019471	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0	0.1	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.1	GO:0072526	pyridine-containing compound catabolic process(GO:0072526)
0.0	0.0	GO:0034135	regulation of toll-like receptor 2 signaling pathway(GO:0034135)
0.0	0.0	GO:0034723	DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.5	GO:0046847	filopodium assembly(GO:0046847)
0.0	0.1	GO:0030033	microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0	0.0	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.1	GO:0045652	regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0	0.0	GO:0002643	regulation of tolerance induction(GO:0002643) positive regulation of tolerance induction(GO:0002645)
0.0	0.0	GO:0045875	negative regulation of sister chromatid cohesion(GO:0045875)
0.0	0.0	GO:0033689	negative regulation of osteoblast proliferation(GO:0033689)
0.0	0.1	GO:0036037	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.0	GO:0060242	contact inhibition(GO:0060242)
0.0	0.0	GO:0044320	cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0	0.0	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.0	0.0	GO:0034626	fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.0	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.0	GO:0033262	regulation of nuclear cell cycle DNA replication(GO:0033262)
0.0	0.0	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.1	GO:0002920	regulation of humoral immune response(GO:0002920)
0.0	0.0	GO:0070254	mucus secretion(GO:0070254)
0.0	0.0	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.1	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0001782	B cell homeostasis(GO:0001782)
0.0	0.0	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.0	GO:0001821	histamine secretion(GO:0001821)
0.0	0.2	GO:0001954	positive regulation of cell-matrix adhesion(GO:0001954)
0.0	0.0	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.1	GO:0030502	negative regulation of bone mineralization(GO:0030502)
0.0	0.2	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.0	GO:0042268	regulation of cytolysis(GO:0042268)
0.0	0.0	GO:0032495	response to muramyl dipeptide(GO:0032495)
0.0	0.1	GO:2000193	positive regulation of fatty acid transport(GO:2000193)
0.0	0.0	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.2	GO:0060334	regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.0	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.0	GO:0032957	inositol trisphosphate metabolic process(GO:0032957)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0031264	death-inducing signaling complex(GO:0031264)
0.2	GO:0002102	podosome(GO:0002102)
0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1	GO:0033270	paranode region of axon(GO:0033270)
0.1	GO:0033268	node of Ranvier(GO:0033268)
0.1	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	GO:0043218	compact myelin(GO:0043218)
0.1	GO:0000145	exocyst(GO:0000145)
0.1	GO:0001891	phagocytic cup(GO:0001891)
0.1	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.1	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.1	GO:0030670	phagocytic vesicle membrane(GO:0030670)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.2	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.2	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.1	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	GO:0019958	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.2	GO:0005522	profilin binding(GO:0005522)
0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.1	GO:0031628	opioid receptor binding(GO:0031628)
0.1	GO:0004144	diacylglycerol O-acyltransferase activity(GO:0004144)
0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	GO:0042608	T cell receptor binding(GO:0042608)
0.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.1	GO:0050700	CARD domain binding(GO:0050700)
0.1	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.1	GO:0030955	potassium ion binding(GO:0030955)
0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	GO:0019863	IgE binding(GO:0019863)
0.1	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.1	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.1	GO:0045569	TRAIL binding(GO:0045569)
0.1	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.1	GO:0005521	lamin binding(GO:0005521)
0.0	GO:0031545	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.1	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	GO:0016972	thiol oxidase activity(GO:0016972)
0.1	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	GO:0015142	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.1	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.1	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	GO:0004949	cannabinoid receptor activity(GO:0004949)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.2	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
1.0	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.4	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.2	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.2	PID TRAIL PATHWAY	TRAIL signaling pathway
0.2	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.4	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.0	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.5	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.1	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.3	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.2	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway