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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for ETV4_ETS2

Z-value: 0.73

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Transcription factors associated with ETV4_ETS2

Gene Symbol Gene ID Gene Info
ETV4
ENSG00000175832.8 ETS variant transcription factor 4
ETS2
ENSG00000157557.7 ETS proto-oncogene 2, transcription factor

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr21_40145836_40145987ETS2313200.225744-0.637.0e-02Click!
chr21_40123884_40124035ETS2532720.1579890.627.4e-02Click!
chr21_40211978_40212129ETS2304930.211955-0.581.0e-01Click!
chr21_40145573_40145724ETS2315830.224902-0.571.1e-01Click!
chr21_40138917_40139228ETS2381590.2037510.541.3e-01Click!
chr17_41623926_41624196ETV42610.873284-0.853.7e-03Click!
chr17_41622914_41623315ETV4330.946190-0.826.6e-03Click!
chr17_41669450_41669625ETV4125490.163785-0.771.6e-02Click!
chr17_41668751_41668949ETV4118620.164855-0.771.6e-02Click!
chr17_41669802_41669953ETV4128890.163264-0.752.0e-02Click!

Activity of the ETV4_ETS2 motif across conditions

Conditions sorted by the z-value of the ETV4_ETS2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr11_63974616_63975431 0.24 FERMT3
 fermitin family member 3
 266
 0.78
chr12_51714745_51715007 0.24 BIN2
 bridging integrator 2
 3023
 0.21
chr9_95857151_95857367 0.23 RP11-274J16.5
552
 0.64
chr9_95726568_95726886 0.23 FGD3
 FYVE, RhoGEF and PH domain containing 3
 484
 0.84
chr11_65407442_65407916 0.21 SIPA1
 signal-induced proliferation-associated 1
 87
 0.92
chr10_73531555_73531706 0.21 C10orf54
 chromosome 10 open reading frame 54
 1625
 0.38
chr4_2800484_2801318 0.20 SH3BP2
 SH3-domain binding protein 2
 176
 0.95
chr22_50319474_50319638 0.19 CRELD2
 cysteine-rich with EGF-like domains 2
 7175
 0.17
chr1_245215310_245215673 0.19 ENSG00000251754
 .
 8261
 0.17
chr17_29814991_29815971 0.18 RAB11FIP4
 RAB11 family interacting protein 4 (class II)
 355
 0.83
chr17_7239932_7240900 0.18 ACAP1
 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
 507
 0.51
chr1_167586551_167586989 0.18 RCSD1
 RCSD domain containing 1
 12560
 0.19
chr10_75624935_75625135 0.18 CAMK2G
 calcium/calmodulin-dependent protein kinase II gamma
 4423
 0.13
chr14_101587281_101587508 0.18 ENSG00000206761
 .
 24638
 0.04
chr13_46752366_46752713 0.18 LCP1
 lymphocyte cytosolic protein 1 (L-plastin)
 3920
 0.19
chrX_129225814_129226276 0.17 ELF4
 E74-like factor 4 (ets domain transcription factor)
 18291
 0.19
chr17_4618141_4618477 0.16 ARRB2
 arrestin, beta 2
 575
 0.53
chr19_1067222_1068216 0.16 HMHA1
 histocompatibility (minor) HA-1
 222
 0.85
chr20_62708665_62709256 0.16 RGS19
 regulator of G-protein signaling 19
 1885
 0.17
chr3_13050979_13051187 0.16 IQSEC1
 IQ motif and Sec7 domain 1
 22547
 0.24
chr1_79111525_79111735 0.16 IFI44
 interferon-induced protein 44
 3886
 0.26
chr13_99195211_99195547 0.16 STK24
 serine/threonine kinase 24
 21127
 0.2
chr19_49839028_49839359 0.16 CD37
 CD37 molecule
 472
 0.63
chr1_160676943_160677601 0.15 CD48
 CD48 molecule
 4321
 0.18
chr3_52279791_52280791 0.15 PPM1M
 protein phosphatase, Mg2+/Mn2+ dependent, 1M
 66
 0.94
chr11_128587302_128587453 0.15 SENCR
 smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA
 21459
 0.17
chr17_66344269_66344555 0.15 ARSG
 arylsulfatase G
 56753
 0.1
chr7_100484820_100485063 0.15 SRRT
 serrate RNA effector molecule homolog (Arabidopsis)
 383
 0.71
chr10_126300385_126300576 0.15 FAM53B-AS1
 FAM53B antisense RNA 1
 91714
 0.07
chr15_102182223_102182374 0.15 ENSG00000252614
 .
 6217
 0.18
chr1_27945148_27945299 0.15 FGR
 feline Gardner-Rasheed sarcoma viral oncogene homolog
 5350
 0.15
chr11_60932018_60932169 0.14 VPS37C
 vacuolar protein sorting 37 homolog C (S. cerevisiae)
 3004
 0.22
chr19_55084758_55085279 0.14 LILRA2
 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
 200
 0.63
chr10_11212951_11213685 0.14 RP3-323N1.2
21
 0.98
chr11_6251374_6251525 0.14 FAM160A2
 family with sequence similarity 160, member A2
 4397
 0.13
chr1_206732541_206732911 0.14 RASSF5
 Ras association (RalGDS/AF-6) domain family member 5
 2233
 0.27
chr12_54866933_54867431 0.14 GTSF1
 gametocyte specific factor 1
 201
 0.92
chr2_106392629_106392859 0.14 NCK2
 NCK adaptor protein 2
 30556
 0.23
chr2_175498105_175498391 0.14 WIPF1
 WAS/WASL interacting protein family, member 1
 1059
 0.58
chr6_144980278_144980429 0.13 UTRN
 utrophin
 627
 0.85
chr7_150329208_150329551 0.13 GIMAP6
 GTPase, IMAP family member 6
 55
 0.98
chr7_50727890_50728167 0.13 GRB10
 growth factor receptor-bound protein 10
 33401
 0.21
chr18_74836287_74836734 0.13 MBP
 myelin basic protein
 3158
 0.38
chr19_1895348_1895705 0.13 SCAMP4
 secretory carrier membrane protein 4
 9687
 0.09
chr17_38478388_38479657 0.13 RARA
 retinoic acid receptor, alpha
 4485
 0.13
chr7_63361181_63361806 0.13 ENSG00000263891
 .
 47
 0.98
chr8_125210334_125210485 0.13 FER1L6-AS2
 FER1L6 antisense RNA 2
 26646
 0.21
chr8_144328075_144328422 0.13 ZFP41
 ZFP41 zinc finger protein
 743
 0.53
chr8_97324979_97325228 0.13 ENSG00000199732
 .
 3553
 0.24
chr10_94590680_94591107 0.13 EXOC6
 exocyst complex component 6
 42
 0.99
chr16_29674660_29674967 0.13 QPRT
 quinolinate phosphoribosyltransferase
 213
 0.51
chr16_17542920_17543071 0.13 XYLT1
 xylosyltransferase I
 21743
 0.29
chr14_101034010_101035263 0.12 BEGAIN
 brain-enriched guanylate kinase-associated
 192
 0.93
chr9_117145588_117145751 0.12 AKNA
 AT-hook transcription factor
 4574
 0.23
chr10_7526759_7527322 0.12 ENSG00000207453
 .
 1731
 0.45
chr8_145086794_145086945 0.12 PARP10
 poly (ADP-ribose) polymerase family, member 10
 71
 0.74
chr13_46752006_46752233 0.12 LCP1
 lymphocyte cytosolic protein 1 (L-plastin)
 4340
 0.19
chr6_111180837_111181007 0.12 ENSG00000199360
 .
 3302
 0.2
chr6_32160504_32160787 0.12 GPSM3
 G-protein signaling modulator 3
 0
 0.94
chr2_220113848_220114166 0.12 STK16
 serine/threonine kinase 16
 3389
 0.09
chr16_79123602_79124194 0.12 RP11-556H2.3
49
 0.98
chr16_29756670_29756842 0.12 AC009133.17
188
 0.77
chr21_15914339_15914644 0.12 SAMSN1
 SAM domain, SH3 domain and nuclear localization signals 1
 4171
 0.29
chr5_14594534_14594878 0.12 FAM105A
 family with sequence similarity 105, member A
 12822
 0.24
chr10_11187446_11187644 0.12 CELF2
 CUGBP, Elav-like family member 2
 19448
 0.19
chr11_47396682_47396833 0.12 SPI1
 spleen focus forming virus (SFFV) proviral integration oncogene
 3185
 0.13
chr1_203734376_203734572 0.12 LAX1
 lymphocyte transmembrane adaptor 1
 169
 0.94
chr6_166747166_166747317 0.11 SFT2D1
 SFT2 domain containing 1
 8838
 0.19
chr20_34078435_34078749 0.11 RP3-477O4.14
151
 0.92
chr1_28213912_28214063 0.11 THEMIS2
 thymocyte selection associated family member 2
 7745
 0.12
chr20_57465496_57466112 0.11 GNAS
 GNAS complex locus
 553
 0.66
chr9_134150778_134151758 0.11 FAM78A
 family with sequence similarity 78, member A
 666
 0.69
chr4_26263054_26263205 0.11 RBPJ
 recombination signal binding protein for immunoglobulin kappa J region
 11100
 0.31
chr3_111851637_111852199 0.11 GCSAM
 germinal center-associated, signaling and motility
 154
 0.73
chr4_1287250_1287401 0.11 MAEA
 macrophage erythroblast attacher
 3642
 0.18
chr2_175357999_175358525 0.11 GPR155
 G protein-coupled receptor 155
 6440
 0.21
chr5_150594214_150594453 0.11 GM2A
 GM2 ganglioside activator
 2622
 0.27
chr5_544016_544540 0.11 ENSG00000264233
 .
 8281
 0.14
chr19_49859286_49859437 0.11 AC010524.4
48
 0.94
chr1_26616865_26617016 0.11 SH3BGRL3
 SH3 domain binding glutamic acid-rich protein like 3
 10327
 0.11
chr19_13206703_13207270 0.11 LYL1
 lymphoblastic leukemia derived sequence 1
 6695
 0.11
chr1_198648918_198649184 0.11 RP11-553K8.5
12861
 0.25
chr9_95532616_95532767 0.11 BICD2
 bicaudal D homolog 2 (Drosophila)
 5597
 0.21
chr20_47377126_47377429 0.11 ENSG00000251876
 .
 21292
 0.24
chr17_2697553_2697769 0.11 RAP1GAP2
 RAP1 GTPase activating protein 2
 2071
 0.29
chr9_126628860_126629011 0.11 DENND1A
 DENN/MADD domain containing 1A
 63451
 0.12
chr19_35645615_35646695 0.11 FXYD5
 FXYD domain containing ion transport regulator 5
 310
 0.8
chr19_10715319_10715578 0.11 SLC44A2
 solute carrier family 44 (choline transporter), member 2
 2262
 0.17
chrX_117832511_117832662 0.11 IL13RA1
 interleukin 13 receptor, alpha 1
 28949
 0.19
chr17_34603649_34603800 0.10 TBC1D3C
 TBC1 domain family, member 3C
 11692
 0.14
chr19_42210710_42210868 0.10 CEACAM5
 carcinoembryonic antigen-related cell adhesion molecule 5
 1715
 0.23
chr1_36042987_36043882 0.10 RP4-728D4.2
104
 0.95
chrX_70328757_70329094 0.10 IL2RG
 interleukin 2 receptor, gamma
 193
 0.89
chr11_117841514_117841665 0.10 IL10RA
 interleukin 10 receptor, alpha
 15474
 0.17
chr9_95787859_95788010 0.10 FGD3
 FYVE, RhoGEF and PH domain containing 3
 10592
 0.19
chr6_106611529_106611909 0.10 RP1-134E15.3
63704
 0.11
chr11_1874347_1875032 0.10 LSP1
 lymphocyte-specific protein 1
 489
 0.65
chr9_117146231_117146573 0.10 AKNA
 AT-hook transcription factor
 3841
 0.25
chr19_48747671_48748205 0.10 CARD8
 caspase recruitment domain family, member 8
 3618
 0.15
chr5_172272383_172272534 0.10 ERGIC1
 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
 11044
 0.19
chr22_27067492_27067685 0.10 CRYBA4
 crystallin, beta A4
 49660
 0.13
chr5_148620092_148620243 0.10 ABLIM3
 actin binding LIM protein family, member 3
 2744
 0.22
chr5_176882439_176883305 0.10 DBN1
 drebrin 1
 6518
 0.1
chr6_41168130_41168571 0.10 TREML2
 triggering receptor expressed on myeloid cells-like 2
 582
 0.65
chr4_148713676_148713874 0.10 ENSG00000264274
 .
 10029
 0.19
chrX_39949292_39950247 0.10 BCOR
 BCL6 corepressor
 6887
 0.33
chr7_119172_119323 0.10 FAM20C
 family with sequence similarity 20, member C
 73722
 0.11
chr1_2480724_2480985 0.10 TNFRSF14
 tumor necrosis factor receptor superfamily, member 14
 6224
 0.1
chr7_73625229_73625469 0.10 LAT2
 linker for activation of T cells family, member 2
 996
 0.49
chr2_242556723_242557374 0.10 THAP4
 THAP domain containing 4
 132
 0.94
chr6_14857980_14858173 0.10 ENSG00000206960
 .
 211310
 0.02
chr15_40598587_40598738 0.10 PLCB2
 phospholipase C, beta 2
 1364
 0.23
chr20_37434091_37434759 0.10 PPP1R16B
 protein phosphatase 1, regulatory subunit 16B
 58
 0.98
chr10_79362617_79362768 0.10 ENSG00000199592
 .
 15885
 0.23
chr19_50400390_50400724 0.09 IL4I1
 interleukin 4 induced 1
 345
 0.67
chr5_95159606_95160004 0.09 GLRX
 glutaredoxin (thioltransferase)
 1096
 0.44
chr20_23063904_23064055 0.09 CD93
 CD93 molecule
 2998
 0.23
chr2_112913175_112913326 0.09 FBLN7
 fibulin 7
 4075
 0.29
chr7_6065805_6065956 0.09 EIF2AK1
 eukaryotic translation initiation factor 2-alpha kinase 1
 303
 0.79
chr16_30915229_30915507 0.09 CTF1
 cardiotrophin 1
 7409
 0.08
chr3_13455515_13455928 0.09 NUP210
 nucleoporin 210kDa
 6088
 0.26
chr1_11800239_11800390 0.09 AGTRAP
 angiotensin II receptor-associated protein
 4082
 0.15
chr17_34617167_34617318 0.09 CCL3L1
 chemokine (C-C motif) ligand 3-like 1
 8477
 0.15
chr3_53201143_53201294 0.09 PRKCD
 protein kinase C, delta
 2073
 0.29
chr1_153363293_153363489 0.09 S100A8
 S100 calcium binding protein A8
 61
 0.95
chr13_99930587_99930738 0.09 GPR18
 G protein-coupled receptor 18
 16664
 0.18
chr22_37637445_37637596 0.09 RAC2
 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
 2768
 0.2
chr2_69062344_69062572 0.09 AC097495.2
322
 0.9
chr11_122587919_122588091 0.09 ENSG00000239079
 .
 9014
 0.25
chr13_25855828_25855979 0.09 MTMR6
 myotubularin related protein 6
 5801
 0.2
chr7_36325944_36326095 0.09 EEPD1
 endonuclease/exonuclease/phosphatase family domain containing 1
 10734
 0.18
chr5_131810697_131810848 0.09 AC116366.6
2037
 0.23
chr2_8612888_8613039 0.09 AC011747.7
202933
 0.03
chr2_232573344_232574118 0.09 PTMA
 prothymosin, alpha
 485
 0.75
chr8_59506492_59506643 0.09 SDCBP
 syndecan binding protein (syntenin)
 28992
 0.19
chr17_72459969_72460120 0.09 CD300A
 CD300a molecule
 2511
 0.22
chr14_51280333_51280548 0.09 RP11-286O18.1
8158
 0.15
chr19_51631094_51631245 0.09 SIGLEC9
 sialic acid binding Ig-like lectin 9
 882
 0.38
chr5_175123540_175123739 0.09 ENSG00000200648
 .
 7262
 0.21
chr11_67176589_67176876 0.09 TBC1D10C
 TBC1 domain family, member 10C
 5072
 0.07
chr13_33607800_33607951 0.09 ENSG00000221677
 .
 7614
 0.24
chr12_15104428_15104579 0.09 ARHGDIB
 Rho GDP dissociation inhibitor (GDI) beta
 418
 0.81
chr15_99192776_99194432 0.09 IGF1R
 insulin-like growth factor 1 receptor
 1331
 0.47
chr10_134365004_134365155 0.09 INPP5A
 inositol polyphosphate-5-phosphatase, 40kDa
 13436
 0.21
chr6_36666192_36666416 0.09 RAB44
 RAB44, member RAS oncogene family
 16952
 0.13
chr2_169961988_169962139 0.09 AC007556.3
4810
 0.25
chr9_102587867_102588202 0.09 NR4A3
 nuclear receptor subfamily 4, group A, member 3
 975
 0.66
chr19_10982465_10983821 0.09 CARM1
 coactivator-associated arginine methyltransferase 1
 764
 0.53
chr21_36900755_36901002 0.09 ENSG00000211590
 .
 192135
 0.03
chr8_125208186_125208337 0.09 FER1L6-AS2
 FER1L6 antisense RNA 2
 24498
 0.22
chr1_203254106_203254257 0.09 BTG2
 BTG family, member 2
 20483
 0.15
chr9_117149358_117150269 0.09 AKNA
 AT-hook transcription factor
 430
 0.85
chr2_149303870_149304072 0.09 MBD5
 methyl-CpG binding domain protein 5
 77677
 0.11
chr15_69961298_69961449 0.09 ENSG00000238870
 .
 61788
 0.13
chr5_131793340_131793491 0.09 ENSG00000202533
 .
 10424
 0.13
chr15_40659564_40659826 0.09 RP11-64K12.4
2146
 0.13
chr17_75437754_75438017 0.09 ENSG00000200651
 .
 306
 0.87
chr9_120477806_120477957 0.09 ENSG00000201444
 .
 7501
 0.21
chr4_169427075_169427226 0.09 PALLD
 palladin, cytoskeletal associated protein
 5569
 0.22
chr6_143177934_143178085 0.09 HIVEP2
 human immunodeficiency virus type I enhancer binding protein 2
 19825
 0.26
chr20_19055744_19055895 0.09 ENSG00000264669
 .
 50610
 0.16
chr6_35279100_35279566 0.09 DEF6
 differentially expressed in FDCP 6 homolog (mouse)
 1818
 0.34
chr7_158505123_158505274 0.09 NCAPG2
 non-SMC condensin II complex, subunit G2
 7678
 0.23
chr3_71493443_71493594 0.09 ENSG00000221264
 .
 97722
 0.08
chr19_30171358_30171509 0.08 PLEKHF1
 pleckstrin homology domain containing, family F (with FYVE domain) member 1
 13652
 0.21
chr1_204482334_204482501 0.08 MDM4
 Mdm4 p53 binding protein homolog (mouse)
 3094
 0.23
chr17_27220072_27220391 0.08 RP11-20B24.7
744
 0.4
chr7_106505707_106506635 0.08 PIK3CG
 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
 247
 0.95
chr21_48042285_48042436 0.08 PRMT2
 protein arginine methyltransferase 2
 12719
 0.2
chr7_137620698_137620944 0.08 CREB3L2
 cAMP responsive element binding protein 3-like 2
 2185
 0.34
chr9_101881133_101881552 0.08 TGFBR1
 transforming growth factor, beta receptor 1
 8715
 0.21
chrX_17848143_17848294 0.08 RAI2
 retinoic acid induced 2
 7632
 0.3
chr7_138757613_138757764 0.08 ZC3HAV1
 zinc finger CCCH-type, antiviral 1
 6325
 0.22
chr6_13636625_13636776 0.08 AL441883.1
 Uncharacterized protein
 15574
 0.14
chr5_156696070_156696221 0.08 CYFIP2
 cytoplasmic FMR1 interacting protein 2
 217
 0.91
chr8_30514582_30515646 0.08 GTF2E2
 general transcription factor IIE, polypeptide 2, beta 34kDa
 21
 0.98
chr7_2684869_2685165 0.08 TTYH3
 tweety family member 3
 149
 0.96
chr10_112619332_112619483 0.08 PDCD4
 programmed cell death 4 (neoplastic transformation inhibitor)
 12158
 0.14
chr7_26415747_26416790 0.08 AC004540.4
53
 0.98
chr8_102150052_102150203 0.08 ENSG00000202360
 .
 60
 0.98
chr10_70804041_70804192 0.08 SRGN
 serglycin
 43758
 0.12
chr7_148844568_148845756 0.08 ZNF398
 zinc finger protein 398
 57
 0.97
chrX_38676446_38676597 0.08 MID1IP1-AS1
 MID1IP1 antisense RNA 1
 13385
 0.23
chr11_64510621_64511071 0.08 RASGRP2
 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
 415
 0.76
chr9_139117966_139118117 0.08 QSOX2
 quiescin Q6 sulfhydryl oxidase 2
 1318
 0.43
chr5_175665565_175666307 0.08 SIMC1
 SUMO-interacting motifs containing 1
 533
 0.81
chr2_70171863_70172014 0.08 ENSG00000239072
 .
 10839
 0.12
chr11_75479321_75480435 0.08 DGAT2
 diacylglycerol O-acyltransferase 2
 21
 0.69
chr9_117690313_117690616 0.08 TNFSF8
 tumor necrosis factor (ligand) superfamily, member 8
 2233
 0.42
chr10_27148230_27149879 0.08 ABI1
 abl-interactor 1
 738
 0.67
chr11_64546452_64546665 0.08 SF1
 splicing factor 1
 300
 0.83
chr1_8285162_8285313 0.08 ENSG00000200975
 .
 18580
 0.19
chr1_6524907_6525205 0.08 TNFRSF25
 tumor necrosis factor receptor superfamily, member 25
 634
 0.58
chr11_64107746_64107914 0.08 CCDC88B
 coiled-coil domain containing 88B
 135
 0.9
chr18_9095215_9095557 0.08 NDUFV2
 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
 7242
 0.18
chr11_133826464_133827261 0.08 IGSF9B
 immunoglobulin superfamily, member 9B
 18
 0.58
chr5_40616837_40616988 0.08 ENSG00000199552
 .
 38153
 0.18
chr1_2509263_2509520 0.08 RP3-395M20.9
3608
 0.12
chr17_81147720_81147871 0.08 METRNL
 meteorin, glial cell differentiation regulator-like
 95801
 0.08
chr8_28918241_28918392 0.08 CTD-2647L4.4
4864
 0.16

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of ETV4_ETS2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0033622 integrin activation(GO:0033622)
0.1 0.3 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0 0.1 GO:0070340 detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0 0.1 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 0.1 GO:0046501 protoporphyrinogen IX metabolic process(GO:0046501)
0.0 0.1 GO:0031053 primary miRNA processing(GO:0031053)
0.0 0.1 GO:1901339 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.1 GO:0002864 regulation of acute inflammatory response to antigenic stimulus(GO:0002864)
0.0 0.1 GO:0042816 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0 0.1 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.1 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:0032656 regulation of interleukin-13 production(GO:0032656)
0.0 0.1 GO:0097576 vacuole fusion(GO:0097576)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.0 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0 0.1 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.1 GO:0032506 cytokinetic process(GO:0032506)
0.0 0.1 GO:0032928 regulation of superoxide anion generation(GO:0032928)
0.0 0.1 GO:0030644 cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0 0.0 GO:0002863 positive regulation of inflammatory response to antigenic stimulus(GO:0002863)
0.0 0.1 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.0 0.1 GO:0009405 pathogenesis(GO:0009405)
0.0 0.1 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.1 GO:0061072 iris morphogenesis(GO:0061072)
0.0 0.1 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.0 0.0 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.0 0.1 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.0 0.1 GO:0002517 T cell tolerance induction(GO:0002517) regulation of T cell tolerance induction(GO:0002664) positive regulation of T cell tolerance induction(GO:0002666)
0.0 0.1 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.0 0.1 GO:0071360 cellular response to exogenous dsRNA(GO:0071360)
0.0 0.0 GO:0019471 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0 0.1 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.1 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
0.0 0.0 GO:0034135 regulation of toll-like receptor 2 signaling pathway(GO:0034135)
0.0 0.0 GO:0034723 DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.5 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.1 GO:0030033 microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0 0.0 GO:0006154 adenosine catabolic process(GO:0006154)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0 0.0 GO:0002643 regulation of tolerance induction(GO:0002643) positive regulation of tolerance induction(GO:0002645)
0.0 0.0 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.0 0.0 GO:0033689 negative regulation of osteoblast proliferation(GO:0033689)
0.0 0.1 GO:0036037 CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.0 GO:0060242 contact inhibition(GO:0060242)
0.0 0.0 GO:0044320 cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0 0.0 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.0 GO:0034626 fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.0 GO:0015917 aminophospholipid transport(GO:0015917)
0.0 0.0 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
0.0 0.0 GO:0003032 detection of oxygen(GO:0003032)
0.0 0.1 GO:0002920 regulation of humoral immune response(GO:0002920)
0.0 0.0 GO:0070254 mucus secretion(GO:0070254)
0.0 0.0 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.1 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0001782 B cell homeostasis(GO:0001782)
0.0 0.0 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.0 0.0 GO:0001821 histamine secretion(GO:0001821)
0.0 0.2 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.0 0.0 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.0 0.1 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.0 0.2 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.0 GO:0042268 regulation of cytolysis(GO:0042268)
0.0 0.0 GO:0032495 response to muramyl dipeptide(GO:0032495)
0.0 0.1 GO:2000193 positive regulation of fatty acid transport(GO:2000193)
0.0 0.0 GO:0070874 negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.2 GO:0060334 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 0.0 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.0 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.2 GO:0002102 podosome(GO:0002102)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.1 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.1 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.1 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.0 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.1 GO:0000145 exocyst(GO:0000145)
0.0 0.1 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.1 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.1 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.2 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.2 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.1 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.0 GO:0019958 C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0 0.1 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.1 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.1 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.0 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.1 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.1 GO:0030955 potassium ion binding(GO:0030955)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0031701 angiotensin receptor binding(GO:0031701)
0.0 0.0 GO:0019863 IgE binding(GO:0019863)
0.0 0.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0015379 potassium:chloride symporter activity(GO:0015379)
0.0 0.0 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.0 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0 0.0 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.1 GO:0045569 TRAIL binding(GO:0045569)
0.0 0.1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0 0.1 GO:0005521 lamin binding(GO:0005521)
0.0 0.0 GO:0031545 procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.0 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.0 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.1 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.0 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.1 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.0 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.0 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 0.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.0 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.0 GO:0015142 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0 0.1 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.1 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0 0.0 GO:0004949 cannabinoid receptor activity(GO:0004949)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.0 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.4 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.2 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.2 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.2 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.4 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.0 0.5 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.1 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.3 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.2 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.1 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway