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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for FOSB

Z-value: 0.97

Motif logo

Transcription factors associated with FOSB

Gene Symbol	Gene ID	Gene Info
FOSB Ensembl NCBI GeneCards UniProt	ENSG00000125740.9	FOSB

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
FOSB	chr19_45970997_45971195	157	0.919518	-0.62	7.3e-02	Click!
FOSB	chr19_45973015_45973567	120	0.935112	-0.48	2.0e-01	Click!
FOSB	chr19_45975714_45975883	2275	0.177319	0.43	2.5e-01	Click!
FOSB	chr19_45975959_45976300	2606	0.160559	0.38	3.1e-01	Click!
FOSB	chr19_45973955_45974106	507	0.666266	-0.36	3.5e-01	Click!

Activity of the FOSB motif across conditions

Conditions sorted by the z-value of the FOSB motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr5_131593477_131594185	0.57	PDLIM4	PDZ and LIM domain 4	431	0.81
chr1_44513542_44514157	0.53	SLC6A9	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	16715	0.14
chr12_72667295_72667865	0.51	TRHDE	thyrotropin-releasing hormone degrading enzyme	317	0.85
chr20_30328267_30328442	0.51	TPX2	TPX2, microtubule-associated	1280	0.36
chr4_107956832_107957922	0.46	DKK2	dickkopf WNT signaling pathway inhibitor 2	77	0.99
chr7_32109441_32109701	0.44	PDE1C	phosphodiesterase 1C, calmodulin-dependent 70kDa	890	0.75
chr7_77169254_77169538	0.43	PTPN12	protein tyrosine phosphatase, non-receptor type 12	2010	0.44
chr4_141217669_141218059	0.39	ENSG00000252300	.	21598	0.19
chr5_158611818_158612659	0.39	RNF145	ring finger protein 145	22404	0.16
chr13_40683698_40683888	0.38	ENSG00000207458	.	117171	0.07
chr13_103478539_103479046	0.37	ENSG00000222301	.	6449	0.13
chr5_15620667_15620944	0.37	FBXL7	F-box and leucine-rich repeat protein 7	4714	0.28
chr17_9018882_9019405	0.36	NTN1	netrin 1	47109	0.15
chr4_77506894_77507309	0.36	ENSG00000265314	.	10397	0.17
chr11_118478413_118479735	0.35	PHLDB1	pleckstrin homology-like domain, family B, member 1	716	0.54
chr2_202774749_202774932	0.35	ENSG00000212184	.	17322	0.18
chr4_71587677_71588145	0.34	RUFY3	RUN and FYVE domain containing 3	183	0.92
chr17_65427494_65427948	0.34	ENSG00000201547	.	22724	0.12
chr3_99359127_99359366	0.33	COL8A1	collagen, type VIII, alpha 1	1792	0.46
chr18_9743562_9744068	0.33	RAB31	RAB31, member RAS oncogene family	35653	0.16
chr3_159483400_159483608	0.33	IQCJ-SCHIP1	IQCJ-SCHIP1 readthrough	612	0.7
chr19_48928010_48928416	0.33	GRWD1	glutamate-rich WD repeat containing 1	20817	0.09
chr6_169828167_169828442	0.33	THBS2	thrombospondin 2	174165	0.03
chr11_10920623_10921193	0.32	ZBED5-AS1	ZBED5 antisense RNA 1	34100	0.15
chr2_167230570_167230946	0.32	SCN9A	sodium channel, voltage-gated, type IX, alpha subunit	1739	0.43
chr12_58129779_58130334	0.32	AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	1563	0.16
chr5_14268280_14268580	0.32	TRIO	trio Rho guanine nucleotide exchange factor	22656	0.28
chr17_74442541_74443075	0.32	UBE2O	ubiquitin-conjugating enzyme E2O	6480	0.12
chr8_23399124_23399403	0.32	SLC25A37	solute carrier family 25 (mitochondrial iron transporter), member 37	12690	0.16
chr3_53303838_53304218	0.31	ENSG00000238565	.	13291	0.12
chr4_23890131_23890306	0.31	PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	1440	0.57
chr19_47735595_47736220	0.31	BBC3	BCL2 binding component 3	116	0.95
chr9_21677527_21678485	0.31	ENSG00000244230	.	21307	0.21
chr12_29310273_29310492	0.31	FAR2	fatty acyl CoA reductase 2	8249	0.26
chr8_132828485_132828822	0.31	EFR3A	EFR3 homolog A (S. cerevisiae)	87682	0.1
chr2_69059738_69059974	0.31	AC097495.2		680	0.71
chr9_124044297_124044511	0.31	RP11-477J21.6		604	0.65
chr12_112204695_112205567	0.30	ALDH2	aldehyde dehydrogenase 2 family (mitochondrial)	405	0.84
chr3_172280513_172281223	0.29	TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	39571	0.16
chr11_57241521_57241817	0.29	RP11-624G17.3		3338	0.12
chr20_2367570_2367721	0.29	TGM6	transglutaminase 6	6091	0.22
chr18_47250302_47250457	0.29	ACAA2	acetyl-CoA acyltransferase 2	87522	0.06
chr3_105663549_105663788	0.29	CBLB	Cbl proto-oncogene B, E3 ubiquitin protein ligase	75272	0.13
chr1_221209086_221209419	0.29	HLX	H2.0-like homeobox	154668	0.04
chr10_95361036_95361311	0.29	RBP4	retinol binding protein 4, plasma	190	0.93
chr2_220173306_220173592	0.29	PTPRN	protein tyrosine phosphatase, receptor type, N	257	0.82
chr8_6404923_6405335	0.29	ANGPT2	angiopoietin 2	15436	0.25
chr8_52782524_52782885	0.28	PCMTD1	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1	24399	0.15
chr1_156863527_156863998	0.28	PEAR1	platelet endothelial aggregation receptor 1	239	0.89
chr3_159745160_159745451	0.28	LINC01100	long intergenic non-protein coding RNA 1100	11494	0.19
chr3_138581962_138582285	0.28	PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	28343	0.2
chr6_52217103_52217563	0.28	PAQR8	progestin and adipoQ receptor family member VIII	8886	0.23
chr16_80933820_80933971	0.28	CDYL2	chromodomain protein, Y-like 2	95669	0.06
chr12_56075239_56075869	0.28	METTL7B	methyltransferase like 7B	224	0.86
chr19_19574756_19575086	0.27	GATAD2A	GATA zinc finger domain containing 2A	570	0.67
chr11_35641995_35642146	0.27	FJX1	four jointed box 1 (Drosophila)	2335	0.36
chr11_63273553_63274069	0.27	LGALS12	lectin, galactoside-binding, soluble, 12	24	0.97
chr8_22343066_22343217	0.27	PPP3CC	protein phosphatase 3, catalytic subunit, gamma isozyme	10036	0.15
chr1_233249017_233249707	0.27	PCNXL2	pecanex-like 2 (Drosophila)	46691	0.19
chr11_12108503_12108884	0.27	MICAL2	microtubule associated monooxygenase, calponin and LIM domain containing 2	6850	0.29
chr13_107001311_107002028	0.27	EFNB2	ephrin-B2	185793	0.03
chr4_71570546_71572213	0.27	RUFY3	RUN and FYVE domain containing 3	861	0.36
chrX_134124848_134125476	0.27	SMIM10	small integral membrane protein 10	194	0.94
chr7_47493101_47493387	0.27	TNS3	tensin 3	415	0.92
chr20_20714689_20714840	0.27	ENSG00000264361	.	4610	0.29
chr4_159090784_159091060	0.27	FAM198B	family with sequence similarity 198, member B	608	0.57
chr3_186470882_186471297	0.26	RP11-573D15.8		164	0.89
chr5_33891538_33892159	0.26	ADAMTS12	ADAM metallopeptidase with thrombospondin type 1 motif, 12	198	0.94
chr2_37116896_37117561	0.26	ENSG00000252756	.	22590	0.18
chr2_28565345_28565858	0.26	AC093690.1		32275	0.15
chr18_47016915_47017206	0.26	ENSG00000206602	.	657	0.29
chr3_25614345_25614537	0.26	ENSG00000272166	.	17344	0.22
chr3_151046365_151046540	0.26	P2RY13	purinergic receptor P2Y, G-protein coupled, 13	884	0.57
chr18_60051802_60052141	0.26	RP11-640A1.3		6608	0.23
chr6_7730907_7731182	0.26	BMP6	bone morphogenetic protein 6	4014	0.34
chr3_146221452_146221714	0.26	PLSCR2	phospholipid scramblase 2	7805	0.22
chr4_138451566_138451717	0.26	PCDH18	protocadherin 18	1924	0.52
chr20_44443275_44443426	0.26	UBE2C	ubiquitin-conjugating enzyme E2C	1705	0.18
chr12_77257769_77258091	0.26	RP11-461F16.3		14043	0.22
chr11_125497290_125497441	0.26	CHEK1	checkpoint kinase 1	722	0.57
chr12_8043530_8043933	0.26	SLC2A14	solute carrier family 2 (facilitated glucose transporter), member 14	13	0.96
chr15_26332761_26333025	0.25	ENSG00000212604	.	78672	0.11
chr4_73433751_73434036	0.25	ADAMTS3	ADAM metallopeptidase with thrombospondin type 1 motif, 3	623	0.85
chr1_180126237_180126440	0.25	QSOX1	quiescin Q6 sulfhydryl oxidase 1	2306	0.36
chr1_231297648_231298418	0.25	TRIM67	tripartite motif containing 67	175	0.95
chr2_18157972_18158481	0.25	ENSG00000212455	.	63773	0.13
chr8_71359441_71359951	0.25	ENSG00000253143	.	33026	0.17
chr17_55980324_55980725	0.25	CUEDC1	CUE domain containing 1	226	0.93
chr11_94829276_94829597	0.25	ENDOD1	endonuclease domain containing 1	6462	0.24
chr15_75943747_75944181	0.25	SNX33	sorting nexin 33	1867	0.18
chr10_114745695_114746021	0.25	RP11-57H14.2		34224	0.18
chr15_80452796_80453143	0.25	FAH	fumarylacetoacetate hydrolase (fumarylacetoacetase)	4676	0.25
chr12_113859774_113860410	0.25	SDSL	serine dehydratase-like	50	0.97
chr4_138975164_138975441	0.24	ENSG00000250033	.	3316	0.4
chr20_50063597_50063893	0.24	ENSG00000266761	.	5769	0.29
chr1_17866743_17867038	0.24	ARHGEF10L	Rho guanine nucleotide exchange factor (GEF) 10-like	560	0.82
chr17_26220981_26221377	0.24	LYRM9	LYR motif containing 9	770	0.4
chr7_40509791_40509942	0.24	AC004988.1		76661	0.12
chr10_74572337_74572942	0.24	RP11-354E23.5		46321	0.13
chr2_238768253_238768964	0.24	RAMP1	receptor (G protein-coupled) activity modifying protein 1	11	0.98
chr7_21981069_21981345	0.24	CDCA7L	cell division cycle associated 7-like	3284	0.37
chr2_200844549_200844884	0.24	C2orf47	chromosome 2 open reading frame 47	24172	0.18
chr9_129884150_129884930	0.24	ANGPTL2	angiopoietin-like 2	373	0.9
chr9_100639076_100639372	0.24	FOXE1	forkhead box E1 (thyroid transcription factor 2)	23688	0.15
chr18_416158_416713	0.24	RP11-720L2.2		7981	0.25
chr2_114643988_114644188	0.23	ACTR3	ARP3 actin-related protein 3 homolog (yeast)	3449	0.28
chr1_211055833_211056141	0.23	KCNH1-IT1	KCNH1 intronic transcript 1 (non-protein coding)	250729	0.02
chr11_1770006_1770588	0.23	IFITM10	interferon induced transmembrane protein 10	1524	0.22
chr3_12549443_12549677	0.23	ENSG00000200114	.	3152	0.17
chr9_3508149_3508375	0.23	RFX3	regulatory factor X, 3 (influences HLA class II expression)	17721	0.25
chr3_11571277_11571505	0.23	VGLL4	vestigial like 4 (Drosophila)	39007	0.18
chr19_38422631_38423016	0.23	SIPA1L3	signal-induced proliferation-associated 1 like 3	24955	0.15
chr9_97663249_97663511	0.23	RP11-49O14.2		669	0.72
chr3_128201686_128201886	0.23	GATA2	GATA binding protein 2	4973	0.17
chr17_33378351_33378574	0.23	ENSG00000238858	.	3051	0.16
chr7_120723258_120723409	0.23	ENSG00000212628	.	534	0.81
chr5_67629922_67630135	0.23	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	41632	0.21
chr1_31501484_31501723	0.23	PUM1	pumilio RNA-binding family member 1	33160	0.16
chr19_6087775_6088269	0.23	CTC-232P5.3		20058	0.13
chr5_141740462_141740706	0.23	AC005592.2		7476	0.26
chr11_78885167_78885414	0.22	TENM4	teneurin transmembrane protein 4	41664	0.21
chr1_32043259_32043540	0.22	TINAGL1	tubulointerstitial nephritis antigen-like 1	1260	0.35
chrX_114796055_114796359	0.22	PLS3	plastin 3	625	0.52
chr9_29039310_29039461	0.22	ENSG00000215939	.	150432	0.05
chr17_66755661_66755820	0.22	ENSG00000263690	.	6960	0.3
chr6_76059036_76059425	0.22	RP11-415D17.3		7700	0.18
chr18_3037544_3037723	0.22	ENSG00000252258	.	12069	0.17
chr17_1666268_1666531	0.22	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	276	0.85
chr3_5181342_5181587	0.22	ARL8B	ADP-ribosylation factor-like 8B	17483	0.16
chr6_162052900_162053180	0.22	ENSG00000221021	.	16942	0.31
chr8_126556861_126557105	0.22	ENSG00000266452	.	100176	0.08
chr17_13501346_13501683	0.22	HS3ST3A1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	3730	0.32
chr10_6763782_6764322	0.22	PRKCQ	protein kinase C, theta	141789	0.05
chr10_99474521_99475206	0.22	MARVELD1	MARVEL domain containing 1	1382	0.36
chr1_192873657_192873883	0.21	ENSG00000223075	.	28655	0.21
chr9_89049595_89049782	0.21	ENSG00000222293	.	11645	0.28
chr5_98396547_98396924	0.21	ENSG00000200351	.	124284	0.06
chr3_188599058_188599349	0.21	TPRG1	tumor protein p63 regulated 1	65800	0.14
chr9_12859535_12860149	0.21	ENSG00000222658	.	25478	0.2
chr1_68024994_68025388	0.21	ENSG00000207504	.	18381	0.23
chr6_113198454_113198633	0.21	ENSG00000201386	.	94152	0.09
chr4_119839531_119839737	0.21	SYNPO2	synaptopodin 2	29442	0.23
chr4_99298536_99298978	0.21	RAP1GDS1	RAP1, GTP-GDP dissociation stimulator 1	1496	0.54
chr8_16689434_16690090	0.21	ENSG00000264092	.	31243	0.24
chr8_104154291_104154696	0.21	C8orf56	chromosome 8 open reading frame 56	790	0.45
chr12_64565605_64565889	0.21	RP11-196H14.3		24110	0.14
chr16_55787112_55787263	0.21	CES1P1	carboxylesterase 1 pseudogene 1	7273	0.24
chr2_197852750_197853145	0.21	ANKRD44	ankyrin repeat domain 44	12279	0.25
chr6_167002477_167002628	0.21	RPS6KA2	ribosomal protein S6 kinase, 90kDa, polypeptide 2	38173	0.16
chr14_106379215_106379366	0.21	ENSG00000233655	.	194	0.61
chr2_158117981_158118132	0.21	GALNT5	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)	3946	0.28
chr15_52860024_52861356	0.21	ARPP19	cAMP-regulated phosphoprotein, 19kDa	339	0.87
chr9_111773050_111773591	0.21	CTNNAL1	catenin (cadherin-associated protein), alpha-like 1	2459	0.23
chr9_130856416_130856740	0.21	RP11-379C10.4		158	0.89
chr11_71811615_71811947	0.21	LAMTOR1	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1	1477	0.2
chr16_85548258_85548499	0.21	ENSG00000264203	.	73280	0.1
chr8_108509260_108510202	0.21	ANGPT1	angiopoietin 1	507	0.89
chr3_185463378_185463630	0.21	ENSG00000265470	.	22188	0.19
chr2_232476974_232477319	0.20	C2orf57	chromosome 2 open reading frame 57	19571	0.16
chr5_71643973_71644124	0.20	PTCD2	pentatricopeptide repeat domain 2	27823	0.16
chr5_87441398_87441596	0.20	TMEM161B	transmembrane protein 161B	74951	0.11
chr8_26123485_26124097	0.20	PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	25216	0.23
chr5_14036568_14037099	0.20	DNAH5	dynein, axonemal, heavy chain 5	92181	0.09
chr12_132221740_132221934	0.20	SFSWAP	splicing factor, suppressor of white-apricot homolog (Drosophila)	15831	0.2
chr15_52167016_52167539	0.20	ENSG00000207484	.	9476	0.13
chr1_54964656_54964938	0.20	ENSG00000265404	.	5544	0.2
chr1_33207592_33208218	0.20	KIAA1522	KIAA1522	419	0.8
chr6_155254000_155254239	0.20	ENSG00000238963	.	27828	0.18
chr16_20922512_20922925	0.20	LYRM1	LYR motif containing 1	10292	0.16
chr5_142206750_142206915	0.20	ARHGAP26-AS1	ARHGAP26 antisense RNA 1	41643	0.17
chr6_72595878_72596126	0.20	RIMS1	regulating synaptic membrane exocytosis 1	404	0.92
chr16_72281740_72281986	0.20	PMFBP1	polyamine modulated factor 1 binding protein 1	71086	0.1
chr4_83706873_83707176	0.20	SCD5	stearoyl-CoA desaturase 5	12885	0.19
chr14_30683326_30683477	0.20	PRKD1	protein kinase D1	22297	0.28
chr1_201852942_201853093	0.20	SHISA4	shisa family member 4	4819	0.14
chr5_95294045_95294496	0.20	ELL2	elongation factor, RNA polymerase II, 2	3282	0.24
chr13_80354703_80354855	0.20	NDFIP2	Nedd4 family interacting protein 2	299191	0.01
chr1_205568507_205568658	0.20	ENSG00000206762	.	4413	0.18
chr3_16006218_16006514	0.20	ENSG00000207815	.	91088	0.08
chr3_36421358_36421509	0.20	STAC	SH3 and cysteine rich domain	403	0.92
chr3_129205233_129205384	0.20	IFT122	intraflagellar transport 122 homolog (Chlamydomonas)	1726	0.3
chr11_48085778_48085988	0.19	ENSG00000263693	.	32451	0.17
chr20_5149549_5150123	0.19	CDS2	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2	9632	0.17
chr1_109262925_109263076	0.19	FNDC7	fibronectin type III domain containing 7	2033	0.27
chr2_136578935_136579086	0.19	AC011893.3		1249	0.42
chr7_127318408_127318559	0.19	SND1	staphylococcal nuclease and tudor domain containing 1	26249	0.16
chr11_48057635_48057786	0.19	AC103828.1		20303	0.19
chr9_110310779_110311295	0.19	KLF4	Kruppel-like factor 4 (gut)	58274	0.13
chr9_18476779_18476930	0.19	ADAMTSL1	ADAMTS-like 1	2623	0.41
chr15_88789971_88790162	0.19	NTRK3	neurotrophic tyrosine kinase, receptor, type 3	5787	0.33
chr15_72529055_72529849	0.19	PKM	pyruvate kinase, muscle	5288	0.17
chr13_110971902_110972142	0.19	COL4A2	collagen, type IV, alpha 2	12408	0.21
chr3_69434805_69435778	0.19	FRMD4B	FERM domain containing 4B	67	0.99
chr8_1703891_1704084	0.19	CTD-2336O2.1		7476	0.21
chr7_100070466_100070929	0.19	TSC22D4	TSC22 domain family, member 4	4998	0.08
chr10_126845563_126845852	0.19	CTBP2	C-terminal binding protein 2	1578	0.53
chr9_25677269_25678110	0.19	TUSC1	tumor suppressor candidate 1	1167	0.68
chr12_54688592_54688942	0.19	NFE2	nuclear factor, erythroid 2	775	0.4
chr3_134202229_134202939	0.19	CEP63	centrosomal protein 63kDa	2001	0.29
chr3_64211567_64211718	0.19	PRICKLE2	prickle homolog 2 (Drosophila)	511	0.83

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of FOSB

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.1	0.3	GO:0060236	regulation of mitotic spindle organization(GO:0060236)
0.1	0.3	GO:0060059	embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.1	0.2	GO:0010193	response to ozone(GO:0010193)
0.1	0.2	GO:0030210	heparin biosynthetic process(GO:0030210)
0.1	0.2	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.1	0.2	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.1	0.2	GO:0016576	histone dephosphorylation(GO:0016576)
0.1	0.2	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.1	0.2	GO:0010715	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.3	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.2	GO:0051014	actin filament severing(GO:0051014)
0.0	0.1	GO:0032344	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0	0.1	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.2	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.2	GO:0045989	positive regulation of striated muscle contraction(GO:0045989)
0.0	0.2	GO:0090083	regulation of inclusion body assembly(GO:0090083)
0.0	0.1	GO:0072201	negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0	0.1	GO:1900116	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.2	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.1	GO:0046813	receptor-mediated virion attachment to host cell(GO:0046813)
0.0	0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.2	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0	0.1	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.3	GO:0090102	cochlea development(GO:0090102)
0.0	0.1	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.0	0.2	GO:0002634	regulation of germinal center formation(GO:0002634)
0.0	0.2	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.1	GO:0046322	negative regulation of fatty acid oxidation(GO:0046322)
0.0	0.1	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.2	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.1	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.0	0.3	GO:0006067	ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0	0.0	GO:0061043	vascular wound healing(GO:0061042) regulation of vascular wound healing(GO:0061043)
0.0	0.1	GO:0033197	response to vitamin E(GO:0033197)
0.0	0.1	GO:0071218	cellular response to misfolded protein(GO:0071218)
0.0	0.1	GO:0016246	RNA interference(GO:0016246)
0.0	0.1	GO:0097531	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0	0.2	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.1	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0002118	aggressive behavior(GO:0002118)
0.0	0.1	GO:0006663	platelet activating factor biosynthetic process(GO:0006663)
0.0	0.1	GO:1904376	negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0	0.1	GO:0071277	cellular response to calcium ion(GO:0071277)
0.0	0.1	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.0	GO:0031394	regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0	0.1	GO:0045618	positive regulation of keratinocyte differentiation(GO:0045618)
0.0	0.1	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.1	GO:0060907	positive regulation of macrophage cytokine production(GO:0060907)
0.0	0.2	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.0	0.0	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.1	GO:0006216	cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0	0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.1	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.1	GO:2000050	regulation of non-canonical Wnt signaling pathway(GO:2000050) regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.0	GO:0060346	bone trabecula formation(GO:0060346) bone trabecula morphogenesis(GO:0061430)
0.0	0.1	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.1	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.3	GO:0034605	cellular response to heat(GO:0034605)
0.0	0.1	GO:0031282	regulation of guanylate cyclase activity(GO:0031282)
0.0	0.0	GO:0010658	striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0	0.1	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0	0.3	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
0.0	0.1	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.1	GO:0045091	regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0	0.1	GO:0032277	negative regulation of gonadotropin secretion(GO:0032277)
0.0	0.0	GO:0043931	ossification involved in bone maturation(GO:0043931)
0.0	0.0	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.1	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.1	GO:0001945	lymph vessel development(GO:0001945)
0.0	0.1	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.1	GO:0042984	amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0	0.1	GO:0043113	receptor clustering(GO:0043113)
0.0	0.1	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.1	GO:0060620	regulation of cholesterol import(GO:0060620) regulation of sterol import(GO:2000909)
0.0	0.0	GO:0032226	positive regulation of synaptic transmission, dopaminergic(GO:0032226)
0.0	0.1	GO:0032986	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0	0.1	GO:0019322	pentose biosynthetic process(GO:0019322)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.4	GO:0030574	collagen catabolic process(GO:0030574)
0.0	0.1	GO:0021936	regulation of cerebellar granule cell precursor proliferation(GO:0021936) positive regulation of cerebellar granule cell precursor proliferation(GO:0021940)
0.0	0.0	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.0	0.0	GO:0042501	serine phosphorylation of STAT protein(GO:0042501)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.1	GO:0060406	positive regulation of penile erection(GO:0060406)
0.0	0.0	GO:0042494	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.1	GO:0008611	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0051045	negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0	0.1	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.1	GO:0003283	atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.3	GO:0048286	lung alveolus development(GO:0048286)
0.0	0.1	GO:0048755	branching morphogenesis of a nerve(GO:0048755)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.1	GO:0007320	insemination(GO:0007320)
0.0	0.0	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.3	GO:0007528	neuromuscular junction development(GO:0007528)
0.0	0.1	GO:0008054	negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054)
0.0	0.1	GO:0010765	positive regulation of sodium ion transport(GO:0010765)
0.0	0.1	GO:0021952	central nervous system projection neuron axonogenesis(GO:0021952)
0.0	0.0	GO:0003323	type B pancreatic cell development(GO:0003323)
0.0	0.4	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.0	GO:0060013	righting reflex(GO:0060013)
0.0	0.1	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.0	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	0.0	GO:0022617	extracellular matrix disassembly(GO:0022617)
0.0	0.0	GO:0017014	protein nitrosylation(GO:0017014) peptidyl-cysteine S-nitrosylation(GO:0018119)
0.0	0.1	GO:0048268	clathrin coat assembly(GO:0048268)
0.0	0.1	GO:0050435	beta-amyloid metabolic process(GO:0050435)
0.0	0.0	GO:0033025	mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0	0.1	GO:0010800	positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0	0.0	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.1	GO:0043537	negative regulation of blood vessel endothelial cell migration(GO:0043537)
0.0	0.1	GO:0099518	vesicle transport along microtubule(GO:0047496) vesicle cytoskeletal trafficking(GO:0099518)
0.0	0.1	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.0	GO:0032641	lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.1	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.0	GO:0060014	granulosa cell differentiation(GO:0060014)
0.0	0.1	GO:0097061	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.2	GO:0016079	synaptic vesicle exocytosis(GO:0016079)
0.0	0.1	GO:0019985	translesion synthesis(GO:0019985)
0.0	0.1	GO:0034393	positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0	0.0	GO:0030917	midbrain-hindbrain boundary development(GO:0030917)
0.0	0.0	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0	0.0	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.1	GO:0090114	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0	0.1	GO:0001738	morphogenesis of a polarized epithelium(GO:0001738)
0.0	0.2	GO:0048010	vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.0	0.0	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005) negative regulation of lipase activity(GO:0060192)
0.0	0.2	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.0	0.0	GO:0045103	intermediate filament-based process(GO:0045103)
0.0	0.0	GO:0002541	activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0	0.1	GO:0008653	lipopolysaccharide metabolic process(GO:0008653)
0.0	0.0	GO:0090281	negative regulation of calcium ion import(GO:0090281) negative regulation of cation transmembrane transport(GO:1904063)
0.0	0.1	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.2	GO:0015701	bicarbonate transport(GO:0015701)
0.0	0.1	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.0	0.0	GO:0034384	high-density lipoprotein particle clearance(GO:0034384)
0.0	0.0	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.2	GO:0050771	negative regulation of axonogenesis(GO:0050771)
0.0	0.1	GO:0006837	serotonin transport(GO:0006837)
0.0	0.0	GO:0072179	nephric duct formation(GO:0072179)
0.0	0.1	GO:0045749	obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0	0.0	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.0	GO:0018206	peptidyl-methionine modification(GO:0018206)
0.0	0.1	GO:0002089	lens morphogenesis in camera-type eye(GO:0002089)
0.0	0.0	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.1	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.0	GO:0000470	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) maturation of LSU-rRNA(GO:0000470)
0.0	0.0	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.0	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.0	GO:0072047	proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.0	0.1	GO:0006657	CDP-choline pathway(GO:0006657)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0070852	cell body fiber(GO:0070852)
0.1	0.4	GO:0098642	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.1	0.3	GO:0071437	invadopodium(GO:0071437)
0.0	0.2	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.0	0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.1	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.1	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.1	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.1	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0043259	laminin-10 complex(GO:0043259)
0.0	0.1	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.2	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.1	GO:0002142	stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0	0.1	GO:0001527	microfibril(GO:0001527)
0.0	0.1	GO:0032591	dendritic spine membrane(GO:0032591)
0.0	0.0	GO:0005927	muscle tendon junction(GO:0005927)
0.0	0.1	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.0	0.1	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.1	GO:0031430	M band(GO:0031430)
0.0	0.2	GO:0005665	DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0	0.1	GO:0005652	nuclear lamina(GO:0005652)
0.0	0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.0	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.0	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	0.1	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.0	GO:0071547	piP-body(GO:0071547)
0.0	0.1	GO:0030673	axolemma(GO:0030673)
0.0	0.0	GO:0005787	signal peptidase complex(GO:0005787)
0.0	0.0	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.0	GO:0008328	ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0	0.0	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.0	0.7	GO:0030426	growth cone(GO:0030426)
0.0	0.0	GO:0031933	telomeric heterochromatin(GO:0031933)
0.0	0.1	GO:0030126	COPI vesicle coat(GO:0030126)
0.0	0.2	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	0.1	GO:0005868	cytoplasmic dynein complex(GO:0005868)
0.0	0.0	GO:0071001	U4/U6 snRNP(GO:0071001)
0.0	0.0	GO:0070545	PeBoW complex(GO:0070545)
0.0	0.4	GO:0044309	neuron spine(GO:0044309)
0.0	0.1	GO:0044291	intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0001098	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.2	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.1	0.2	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.1	0.2	GO:0070492	oligosaccharide binding(GO:0070492)
0.1	0.2	GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.1	0.3	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	0.3	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.2	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.1	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.2	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.2	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.1	GO:0004466	long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.0	0.2	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.1	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.1	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.1	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.0	0.1	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.0	0.1	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.1	GO:0016972	thiol oxidase activity(GO:0016972)
0.0	0.1	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.1	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.1	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.0	GO:0031782	melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0	0.1	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.0	0.3	GO:0019841	retinol binding(GO:0019841)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.2	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.1	GO:0004082	bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0	0.2	GO:0019966	interleukin-1 binding(GO:0019966)
0.0	0.1	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	0.4	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	0.1	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.1	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.1	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.0	0.2	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.2	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.1	GO:0031491	nucleosome binding(GO:0031491)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.1	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.1	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.1	GO:0030172	troponin C binding(GO:0030172)
0.0	0.1	GO:0004461	lactose synthase activity(GO:0004461)
0.0	0.1	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.1	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.1	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.3	GO:0005109	frizzled binding(GO:0005109)
0.0	0.1	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)
0.0	0.1	GO:0015245	fatty acid transporter activity(GO:0015245)
0.0	0.1	GO:0070063	RNA polymerase binding(GO:0070063)
0.0	0.0	GO:0034584	piRNA binding(GO:0034584)
0.0	0.1	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.2	GO:0005355	glucose transmembrane transporter activity(GO:0005355)
0.0	0.0	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0030544	Hsp70 protein binding(GO:0030544)
0.0	0.2	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.1	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.0	GO:0016728	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.2	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	0.2	GO:0030169	low-density lipoprotein particle binding(GO:0030169)
0.0	0.1	GO:0004126	cytidine deaminase activity(GO:0004126)
0.0	0.0	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.2	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.1	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.3	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.0	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0	0.0	GO:0045159	myosin II binding(GO:0045159)
0.0	0.2	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0008048	calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0	0.3	GO:0004177	aminopeptidase activity(GO:0004177)
0.0	0.1	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0	0.1	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	0.0	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.1	GO:0005112	Notch binding(GO:0005112)
0.0	0.1	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.0	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.0	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.0	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.0	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0	0.1	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.0	GO:0015065	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.1	GO:0008504	monoamine transmembrane transporter activity(GO:0008504)
0.0	0.0	GO:0055077	gap junction hemi-channel activity(GO:0055077)
0.0	0.1	GO:0000405	bubble DNA binding(GO:0000405)
0.0	0.0	GO:0004802	transketolase activity(GO:0004802)
0.0	0.1	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.0	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.0	GO:0005275	amine transmembrane transporter activity(GO:0005275)
0.0	0.2	GO:0015026	coreceptor activity(GO:0015026)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.1	GO:0030247	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.2	GO:0005248	voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0	0.1	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.0	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0034483	heparan sulfate sulfotransferase activity(GO:0034483)
0.0	0.1	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.1	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.0	0.0	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.0	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.1	GO:0017166	vinculin binding(GO:0017166)
0.0	0.0	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894)
0.0	0.2	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	0.0	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.2	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.5	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.2	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.0	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.6	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.8	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.3	NABA COLLAGENS	Genes encoding collagen proteins
0.1	ST G ALPHA S PATHWAY	G alpha s Pathway
0.3	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.4	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.3	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.7	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.5	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.3	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.3	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.1	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.3	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.5	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	REACTOME GAB1 SIGNALOSOME	Genes involved in GAB1 signalosome
0.2	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.2	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.2	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.2	REACTOME SHC MEDIATED SIGNALLING	Genes involved in SHC-mediated signalling
0.8	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.1	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.1	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.3	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.2	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	REACTOME SHC RELATED EVENTS	Genes involved in SHC-related events
0.1	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	REACTOME REGULATION OF APOPTOSIS	Genes involved in Regulation of Apoptosis
0.2	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.2	REACTOME PHOSPHORYLATION OF THE APC C	Genes involved in Phosphorylation of the APC/C
0.0	REACTOME G ALPHA1213 SIGNALLING EVENTS	Genes involved in G alpha (12/13) signalling events
0.1	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation