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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for FOSL1

Z-value: 0.40

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Transcription factors associated with FOSL1

Gene Symbol	Gene ID	Gene Info
FOSL1 Ensembl NCBI GeneCards UniProt	ENSG00000175592.4	FOSL1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
FOSL1	chr11_65667259_65667446	538	0.549011	0.58	1.0e-01	Click!
FOSL1	chr11_65667492_65667657	316	0.748972	0.49	1.8e-01	Click!
FOSL1	chr11_65667660_65668040	40	0.936875	0.48	1.9e-01	Click!
FOSL1	chr11_65666966_65667198	808	0.376641	0.36	3.4e-01	Click!
FOSL1	chr11_65664383_65664636	3381	0.097737	0.33	3.8e-01	Click!

Activity of the FOSL1 motif across conditions

Conditions sorted by the z-value of the FOSL1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr10_21462508_21463481	0.11	NEBL-AS1	NEBL antisense RNA 1	51	0.59
chr4_40578981_40579556	0.10	RBM47	RNA binding motif protein 47	52613	0.14
chr17_75439465_75439616	0.10	ENSG00000200651	.	1349	0.37
chr4_15907365_15907907	0.10	FGFBP1	fibroblast growth factor binding protein 1	32335	0.17
chr2_69059738_69059974	0.09	AC097495.2		680	0.71
chr3_53303838_53304218	0.09	ENSG00000238565	.	13291	0.12
chr17_75120485_75120909	0.09	SEC14L1	SEC14-like 1 (S. cerevisiae)	3258	0.26
chr16_434070_434221	0.09	TMEM8A	transmembrane protein 8A	2163	0.17
chr6_1614377_1614621	0.09	FOXC1	forkhead box C1	3818	0.36
chr4_185735728_185735879	0.09	RP11-701P16.2	Uncharacterized protein	1030	0.49
chr2_26992134_26992285	0.09	SLC35F6	solute carrier family 35, member F6	5052	0.2
chr9_71590240_71590555	0.09	PRKACG	protein kinase, cAMP-dependent, catalytic, gamma	38642	0.15
chr4_38762729_38763007	0.09	ENSG00000222230	.	2355	0.26
chr1_100865744_100865895	0.08	ENSG00000216067	.	21488	0.18
chr18_9743562_9744068	0.08	RAB31	RAB31, member RAS oncogene family	35653	0.16
chrX_38729814_38730081	0.08	MID1IP1-AS1	MID1IP1 antisense RNA 1	66811	0.12
chr3_169583101_169583252	0.08	LRRC31	leucine rich repeat containing 31	4445	0.16
chr16_31367909_31368060	0.08	ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)	1441	0.29
chr11_2954272_2954423	0.08	PHLDA2	pleckstrin homology-like domain, family A, member 2	3662	0.15
chr7_143081157_143081800	0.08	ZYX	zyxin	1385	0.27
chr19_54603941_54604092	0.08	OSCAR	osteoclast associated, immunoglobulin-like receptor	67	0.93
chr8_8945449_8945788	0.08	ENSG00000239078	.	15592	0.15
chr2_111751565_111751824	0.08	ACOXL	acyl-CoA oxidase-like	6919	0.31
chr3_46989936_46990087	0.08	CCDC12	coiled-coil domain containing 12	28259	0.13
chr3_58320901_58321052	0.08	PXK	PX domain containing serine/threonine kinase	1943	0.34
chr8_134156595_134156746	0.08	TG	thyroglobulin	30923	0.17
chr20_6750709_6750962	0.08	BMP2	bone morphogenetic protein 2	2524	0.43
chr16_31276706_31276857	0.07	ENSG00000252876	.	2031	0.19
chr19_44179596_44179898	0.07	PLAUR	plasminogen activator, urokinase receptor	5048	0.11
chr11_121337447_121337703	0.07	RP11-730K11.1		13853	0.23
chr10_94520371_94520715	0.07	ENSG00000201412	.	50178	0.13
chr3_149371875_149372212	0.07	WWTR1-AS1	WWTR1 antisense RNA 1	2764	0.22
chr4_88817282_88817552	0.07	MEPE	matrix extracellular phosphoglycoprotein	63278	0.1
chr17_55980324_55980725	0.07	CUEDC1	CUE domain containing 1	226	0.93
chrX_48956913_48957064	0.07	WDR45	WD repeat domain 45	1071	0.31
chr6_133006336_133006628	0.07	VNN1	vanin 1	28706	0.12
chr2_42345389_42345540	0.07	EML4	echinoderm microtubule associated protein like 4	51026	0.13
chr9_81879361_81879950	0.07	TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	307033	0.01
chr12_54688592_54688942	0.07	NFE2	nuclear factor, erythroid 2	775	0.4
chr7_28725630_28725928	0.07	CREB5	cAMP responsive element binding protein 5	181	0.97
chr9_111396808_111397109	0.07	ACTL7B	actin-like 7B	222281	0.02
chr11_93270941_93271177	0.07	SMCO4	single-pass membrane protein with coiled-coil domains 4	22	0.98
chr11_1884799_1884950	0.07	LSP1	lymphocyte-specific protein 1	398	0.51
chr2_70224516_70224667	0.07	PCBP1-AS1	PCBP1 antisense RNA 1	618	0.69
chr5_158611818_158612659	0.07	RNF145	ring finger protein 145	22404	0.16
chr20_48989399_48989550	0.07	ENSG00000244376	.	56546	0.13
chr8_142137516_142137731	0.07	RP11-809O17.1		597	0.62
chr4_166361643_166362016	0.07	CPE	carboxypeptidase E	22451	0.23
chr3_151046365_151046540	0.07	P2RY13	purinergic receptor P2Y, G-protein coupled, 13	884	0.57
chr1_42420201_42420352	0.07	HIVEP3	human immunodeficiency virus type I enhancer binding protein 3	35898	0.22
chr10_106079197_106079348	0.07	RP11-127L20.5		7373	0.13
chr6_34283894_34284092	0.06	C6orf1	chromosome 6 open reading frame 1	66746	0.09
chr8_126308914_126309065	0.06	ENSG00000242170	.	26143	0.21
chr2_37116896_37117561	0.06	ENSG00000252756	.	22590	0.18
chr9_132579196_132579347	0.06	TOR1A	torsin family 1, member A (torsin A)	7142	0.14
chr15_58624481_58624632	0.06	ALDH1A2	aldehyde dehydrogenase 1 family, member A2	53094	0.15
chrX_109083591_109084037	0.06	ENSG00000252069	.	95836	0.08
chr8_23399124_23399403	0.06	SLC25A37	solute carrier family 25 (mitochondrial iron transporter), member 37	12690	0.16
chr4_74573765_74574020	0.06	IL8	interleukin 8	32331	0.19
chr20_44439937_44440088	0.06	UBE2C	ubiquitin-conjugating enzyme E2C	1203	0.27
chr16_89396583_89396806	0.06	ANKRD11	ankyrin repeat domain 11	1300	0.35
chr11_67917703_67917854	0.06	CTD-2655K5.1		20513	0.14
chr4_27985809_27985960	0.06	RP11-180C1.1	Uncharacterized protein	418439	0.01
chr17_55945610_55945963	0.06	CUEDC1	CUE domain containing 1	1010	0.52
chr18_21442082_21442233	0.06	LAMA3	laminin, alpha 3	10647	0.22
chr2_143828948_143829099	0.06	ARHGAP15	Rho GTPase activating protein 15	19908	0.24
chr1_161600101_161600252	0.06	FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	646	0.42
chr19_12899780_12900482	0.06	JUNB	jun B proto-oncogene	2179	0.11
chr8_22921887_22922169	0.06	RP11-875O11.2		3714	0.14
chrX_38728231_38728382	0.06	MID1IP1-AS1	MID1IP1 antisense RNA 1	65170	0.13
chr4_10182968_10183393	0.06	WDR1	WD repeat domain 1	64607	0.11
chr8_128310206_128310357	0.06	POU5F1B	POU class 5 homeobox 1B	116254	0.07
chr1_159061696_159061989	0.06	AIM2	absent in melanoma 2	15151	0.17
chr9_136037311_136037462	0.06	GBGT1	globoside alpha-1,3-N-acetylgalactosaminyltransferase 1	1896	0.23
chr19_18526600_18526768	0.06	SSBP4	single stranded DNA binding protein 4	2990	0.12
chr13_31270968_31271119	0.06	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	38602	0.18
chr4_105982370_105982725	0.06	ENSG00000252136	.	44597	0.16
chr6_24950848_24950999	0.06	FAM65B	family with sequence similarity 65, member B	14735	0.22
chr4_79473579_79473973	0.06	ANXA3	annexin A3	655	0.79
chr4_87932888_87933250	0.06	AFF1	AF4/FMR2 family, member 1	4648	0.31
chr21_28802590_28802741	0.06	ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif, 5	463833	0.01
chr3_101655473_101655624	0.06	ENSG00000202177	.	18373	0.23
chr11_2395489_2395640	0.06	ENSG00000199550	.	1696	0.2
chr15_89710840_89711060	0.06	RLBP1	retinaldehyde binding protein 1	44124	0.12
chr15_37402275_37402801	0.06	MEIS2	Meis homeobox 2	9034	0.23
chrX_130199798_130199949	0.06	ARHGAP36	Rho GTPase activating protein 36	7089	0.23
chr11_85852849_85853000	0.06	ENSG00000200877	.	11345	0.22
chr5_171279662_171279813	0.06	SMIM23	small integral membrane protein 23	66847	0.11
chr17_27482435_27482735	0.06	RP11-321A17.4		15084	0.15
chr1_95261518_95261669	0.06	SLC44A3	solute carrier family 44, member 3	24305	0.19
chr7_127662588_127662739	0.06	LRRC4	leucine rich repeat containing 4	8395	0.26
chr10_121031057_121031208	0.06	ENSG00000242853	.	58763	0.09
chr1_6659470_6659968	0.06	KLHL21	kelch-like family member 21	157	0.92
chr1_28502388_28502717	0.06	PTAFR	platelet-activating factor receptor	1147	0.35
chr1_44985301_44985452	0.06	ENSG00000263381	.	25789	0.18
chr6_13573909_13574318	0.06	SIRT5	sirtuin 5	713	0.62
chr9_67026589_67026806	0.06	ENSG00000265285	.	68236	0.13
chr12_57642712_57642903	0.06	STAC3	SH3 and cysteine rich domain 3	2160	0.17
chr1_151579139_151579290	0.05	SNX27	sorting nexin family member 27	5344	0.12
chr7_100070466_100070929	0.05	TSC22D4	TSC22 domain family, member 4	4998	0.08
chr3_50658137_50658523	0.05	MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	3509	0.19
chr13_114830089_114831005	0.05	RASA3	RAS p21 protein activator 3	12891	0.24
chr1_214649424_214649729	0.05	PTPN14	protein tyrosine phosphatase, non-receptor type 14	11430	0.29
chr13_73634006_73635089	0.05	KLF5	Kruppel-like factor 5 (intestinal)	1617	0.45
chr4_166256749_166256900	0.05	MSMO1	methylsterol monooxygenase 1	7745	0.21
chr12_20522251_20522500	0.05	PDE3A	phosphodiesterase 3A, cGMP-inhibited	196	0.89
chr15_99074007_99074158	0.05	FAM169B	family with sequence similarity 169, member B	16471	0.27
chr6_35568962_35570321	0.05	ENSG00000212579	.	49954	0.1
chr2_147579520_147579813	0.05	ENSG00000238860	.	501873	0.0
chr15_91459213_91459364	0.05	MAN2A2	mannosidase, alpha, class 2A, member 2	3170	0.11
chr12_6855415_6855566	0.05	MLF2	myeloid leukemia factor 2	6354	0.08
chr22_37960000_37960286	0.05	CDC42EP1	CDC42 effector protein (Rho GTPase binding) 1	270	0.86
chr3_132105351_132105502	0.05	DNAJC13	DnaJ (Hsp40) homolog, subfamily C, member 13	30944	0.18
chr1_149369357_149369823	0.05	FCGR1C	Fc fragment of IgG, high affinity Ic, receptor (CD64), pseudogene	233	0.9
chr22_35697778_35697929	0.05	TOM1	target of myb1 (chicken)	1966	0.25
chr15_51633704_51634417	0.05	GLDN	gliomedin	234	0.91
chr1_28189787_28189938	0.05	THEMIS2	thymocyte selection associated family member 2	9193	0.11
chr1_226830744_226831144	0.05	ITPKB-IT1	ITPKB intronic transcript 1 (non-protein coding)	16427	0.2
chr20_31888809_31889213	0.05	BPIFB1	BPI fold containing family B, member 1	18070	0.15
chr9_37953977_37954130	0.05	ENSG00000251745	.	17288	0.22
chr9_69655552_69655703	0.05	AL445665.1	Protein LOC100996643	5364	0.29
chr6_109288373_109288524	0.05	RP11-787I22.3		31237	0.15
chr10_101908565_101908716	0.05	ERLIN1	ER lipid raft associated 1	37146	0.11
chr19_12893555_12894002	0.05	ENSG00000263800	.	4164	0.08
chr19_4374737_4374888	0.05	SH3GL1	SH3-domain GRB2-like 1	5477	0.08
chr2_218559547_218559837	0.05	DIRC3	disrupted in renal carcinoma 3	61586	0.14
chr9_42853652_42853803	0.05	AC129778.2		2565	0.39
chr3_194875945_194876317	0.05	XXYLT1-AS2	XXYLT1 antisense RNA 2	7511	0.15
chr3_12504067_12504243	0.05	TSEN2	TSEN2 tRNA splicing endonuclease subunit	21776	0.15
chr20_48909337_48909488	0.05	CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	102036	0.06
chr1_176180985_176181136	0.05	RP11-195C7.1		4276	0.23
chr22_24903141_24903292	0.05	AP000355.2		9260	0.13
chr4_166143196_166143347	0.05	KLHL2	kelch-like family member 2	2118	0.32
chr2_64440045_64440196	0.05	AC074289.1		6011	0.28
chr11_46697090_46697391	0.05	ATG13	autophagy related 13	11690	0.13
chr18_57569513_57570014	0.05	PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	2515	0.37
chr11_119583713_119583864	0.05	PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	15475	0.18
chr1_33807573_33808014	0.05	ENSG00000222112	.	5328	0.13
chr19_1168749_1168988	0.05	SBNO2	strawberry notch homolog 2 (Drosophila)	74	0.95
chr16_85096756_85096907	0.05	KIAA0513	KIAA0513	13	0.98
chr14_70059974_70060446	0.05	KIAA0247	KIAA0247	18103	0.2
chr5_96126813_96126964	0.05	CTD-2260A17.1		6224	0.15
chr8_129262963_129263114	0.05	ENSG00000201782	.	30288	0.23
chr3_112930660_112930893	0.05	BOC	BOC cell adhesion associated, oncogene regulated	266	0.93
chr4_108745530_108746004	0.05	SGMS2	sphingomyelin synthase 2	48	0.98
chrX_9881450_9881696	0.05	SHROOM2	shroom family member 2	850	0.65
chr5_7676594_7676745	0.05	ADCY2	adenylate cyclase 2 (brain)	22605	0.24
chr3_15310922_15311111	0.05	SH3BP5	SH3-domain binding protein 5 (BTK-associated)	6400	0.15
chr3_42138838_42138989	0.05	TRAK1	trafficking protein, kinesin binding 1	6351	0.29
chr9_114614096_114614247	0.05	ENSG00000206907	.	12063	0.2
chr1_36816210_36816695	0.05	STK40	serine/threonine kinase 40	10489	0.13
chr5_100113349_100113842	0.05	ENSG00000221263	.	38674	0.19
chr6_18488896_18489181	0.05	ENSG00000207775	.	82977	0.09
chr7_29153330_29153633	0.05	CPVL	carboxypeptidase, vitellogenic-like	97	0.97
chr1_109373299_109373450	0.05	AKNAD1	AKNA domain containing 1	21965	0.15
chr19_11449251_11449402	0.05	RAB3D	RAB3D, member RAS oncogene family	1018	0.31
chr9_132251498_132251652	0.05	ENSG00000264298	.	10740	0.21
chr19_39889302_39889453	0.05	MED29	mediator complex subunit 29	7325	0.08
chr4_141077504_141077678	0.05	MAML3	mastermind-like 3 (Drosophila)	2253	0.36
chr16_279128_279418	0.05	LUC7L	LUC7-like (S. cerevisiae)	148	0.91
chr7_20824481_20824853	0.05	SP8	Sp8 transcription factor	1838	0.51
chr8_11706405_11706556	0.05	RP11-589N15.2		2580	0.22
chr9_6417233_6417502	0.05	UHRF2	ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase	3664	0.25
chr19_11202980_11203131	0.05	LDLR	low density lipoprotein receptor	1780	0.29
chr4_1716841_1717066	0.05	SLBP	stem-loop binding protein	2671	0.19
chr7_102990167_102990648	0.05	PSMC2	proteasome (prosome, macropain) 26S subunit, ATPase, 2	2297	0.25
chr15_92619299_92619450	0.05	RP11-24J19.1		96292	0.09
chr6_42301055_42301206	0.05	ENSG00000221252	.	79004	0.08
chr10_114746275_114746635	0.05	RP11-57H14.2		34821	0.18
chr1_23912147_23912298	0.05	ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	25937	0.15
chr7_36603678_36603829	0.05	AOAH	acyloxyacyl hydrolase (neutrophil)	30509	0.17
chr2_139274196_139274347	0.05	SPOPL	speckle-type POZ protein-like	14900	0.31
chr5_6705329_6705480	0.05	PAPD7	PAP associated domain containing 7	9314	0.26
chr6_14744303_14744454	0.05	ENSG00000206960	.	97612	0.09
chr2_28177663_28177868	0.05	ENSG00000265321	.	41469	0.15
chr12_54585165_54585441	0.04	SMUG1	single-strand-selective monofunctional uracil-DNA glycosylase 1	2525	0.18
chrX_87167581_87167854	0.04	ENSG00000252016	.	236076	0.02
chr12_3277666_3277860	0.04	TSPAN9-IT1	TSPAN9 intronic transcript 1 (non-protein coding)	18800	0.21
chr10_35927790_35928179	0.04	ENSG00000264780	.	2196	0.26
chr10_45872200_45872351	0.04	ALOX5	arachidonate 5-lipoxygenase	2600	0.34
chr1_149754304_149754780	0.04	FCGR1A	Fc fragment of IgG, high affinity Ia, receptor (CD64)	296	0.78
chr14_75590762_75591162	0.04	NEK9	NIMA-related kinase 9	2781	0.19
chr2_173557887_173558038	0.04	ENSG00000239041	.	1935	0.35
chr7_55620313_55620510	0.04	VOPP1	vesicular, overexpressed in cancer, prosurvival protein 1	134	0.97
chr19_2169086_2169237	0.04	DOT1L	DOT1-like histone H3K79 methyltransferase	4977	0.13
chr2_191278529_191278680	0.04	MFSD6	major facilitator superfamily domain containing 6	5523	0.22
chr22_30642991_30643200	0.04	LIF	leukemia inhibitory factor	255	0.78
chr19_49071767_49072143	0.04	SULT2B1	sulfotransferase family, cytosolic, 2B, member 1	6842	0.11
chr11_64099501_64099713	0.04	AP003774.1		2631	0.11
chr9_67293693_67293844	0.04	RP11-236F9.2		8470	0.29
chr8_142141679_142142152	0.04	RP11-809O17.1		1855	0.33
chrX_109124093_109124244	0.04	TMEM164	transmembrane protein 164	121695	0.05
chr9_124044853_124045004	0.04	RP11-477J21.6		80	0.96
chr15_43531850_43532099	0.04	ENSG00000202211	.	7904	0.13
chr8_38856565_38856716	0.04	ADAM9	ADAM metallopeptidase domain 9	2135	0.22
chr19_47853304_47853535	0.04	DHX34	DEAH (Asp-Glu-Ala-His) box polypeptide 34	881	0.52
chrX_147691631_147691782	0.04	AFF2-IT1	AFF2 intronic transcript 1 (non-protein coding)	63307	0.14
chr15_80452796_80453143	0.04	FAH	fumarylacetoacetate hydrolase (fumarylacetoacetase)	4676	0.25
chr11_65667660_65668040	0.04	FOSL1	FOS-like antigen 1	40	0.94
chr22_40832446_40832730	0.04	RP5-1042K10.13		21581	0.14

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of FOSL1

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Total log-likelihood	Term	Description
0.1	GO:0046022	regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.1	GO:0051459	corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0	GO:0003181	atrioventricular valve development(GO:0003171) atrioventricular valve morphogenesis(GO:0003181)
0.0	GO:0002283	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0	GO:0030210	heparin biosynthetic process(GO:0030210)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.2	GO:0019864	IgG binding(GO:0019864)
0.0	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	GO:0016362	activin receptor activity, type II(GO:0016362)
0.0	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)