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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for FOSL1

Z-value: 0.40

Motif logo

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Transcription factors associated with FOSL1

Gene Symbol Gene ID Gene Info
FOSL1
ENSG00000175592.4 FOS like 1, AP-1 transcription factor subunit

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr11_65667259_65667446FOSL15380.5490110.581.0e-01Click!
chr11_65667492_65667657FOSL13160.7489720.491.8e-01Click!
chr11_65667660_65668040FOSL1400.9368750.481.9e-01Click!
chr11_65666966_65667198FOSL18080.3766410.363.4e-01Click!
chr11_65664383_65664636FOSL133810.0977370.333.8e-01Click!

Activity of the FOSL1 motif across conditions

Conditions sorted by the z-value of the FOSL1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr10_21462508_21463481 0.11 NEBL-AS1
 NEBL antisense RNA 1
 51
 0.59
chr4_40578981_40579556 0.10 RBM47
 RNA binding motif protein 47
 52613
 0.14
chr17_75439465_75439616 0.10 ENSG00000200651
 .
 1349
 0.37
chr4_15907365_15907907 0.10 FGFBP1
 fibroblast growth factor binding protein 1
 32335
 0.17
chr2_69059738_69059974 0.09 AC097495.2
680
 0.71
chr3_53303838_53304218 0.09 ENSG00000238565
 .
 13291
 0.12
chr17_75120485_75120909 0.09 SEC14L1
 SEC14-like 1 (S. cerevisiae)
 3258
 0.26
chr16_434070_434221 0.09 TMEM8A
 transmembrane protein 8A
 2163
 0.17
chr6_1614377_1614621 0.09 FOXC1
 forkhead box C1
 3818
 0.36
chr4_185735728_185735879 0.09 RP11-701P16.2
 Uncharacterized protein
 1030
 0.49
chr2_26992134_26992285 0.09 SLC35F6
 solute carrier family 35, member F6
 5052
 0.2
chr9_71590240_71590555 0.09 PRKACG
 protein kinase, cAMP-dependent, catalytic, gamma
 38642
 0.15
chr4_38762729_38763007 0.09 ENSG00000222230
 .
 2355
 0.26
chr1_100865744_100865895 0.08 ENSG00000216067
 .
 21488
 0.18
chr18_9743562_9744068 0.08 RAB31
 RAB31, member RAS oncogene family
 35653
 0.16
chrX_38729814_38730081 0.08 MID1IP1-AS1
 MID1IP1 antisense RNA 1
 66811
 0.12
chr3_169583101_169583252 0.08 LRRC31
 leucine rich repeat containing 31
 4445
 0.16
chr16_31367909_31368060 0.08 ITGAX
 integrin, alpha X (complement component 3 receptor 4 subunit)
 1441
 0.29
chr11_2954272_2954423 0.08 PHLDA2
 pleckstrin homology-like domain, family A, member 2
 3662
 0.15
chr7_143081157_143081800 0.08 ZYX
 zyxin
 1385
 0.27
chr19_54603941_54604092 0.08 OSCAR
 osteoclast associated, immunoglobulin-like receptor
 67
 0.93
chr8_8945449_8945788 0.08 ENSG00000239078
 .
 15592
 0.15
chr2_111751565_111751824 0.08 ACOXL
 acyl-CoA oxidase-like
 6919
 0.31
chr3_46989936_46990087 0.08 CCDC12
 coiled-coil domain containing 12
 28259
 0.13
chr3_58320901_58321052 0.08 PXK
 PX domain containing serine/threonine kinase
 1943
 0.34
chr8_134156595_134156746 0.08 TG
 thyroglobulin
 30923
 0.17
chr20_6750709_6750962 0.08 BMP2
 bone morphogenetic protein 2
 2524
 0.43
chr16_31276706_31276857 0.07 ENSG00000252876
 .
 2031
 0.19
chr19_44179596_44179898 0.07 PLAUR
 plasminogen activator, urokinase receptor
 5048
 0.11
chr11_121337447_121337703 0.07 RP11-730K11.1
13853
 0.23
chr10_94520371_94520715 0.07 ENSG00000201412
 .
 50178
 0.13
chr3_149371875_149372212 0.07 WWTR1-AS1
 WWTR1 antisense RNA 1
 2764
 0.22
chr4_88817282_88817552 0.07 MEPE
 matrix extracellular phosphoglycoprotein
 63278
 0.1
chr17_55980324_55980725 0.07 CUEDC1
 CUE domain containing 1
 226
 0.93
chrX_48956913_48957064 0.07 WDR45
 WD repeat domain 45
 1071
 0.31
chr6_133006336_133006628 0.07 VNN1
 vanin 1
 28706
 0.12
chr2_42345389_42345540 0.07 EML4
 echinoderm microtubule associated protein like 4
 51026
 0.13
chr9_81879361_81879950 0.07 TLE4
 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
 307033
 0.01
chr12_54688592_54688942 0.07 NFE2
 nuclear factor, erythroid 2
 775
 0.4
chr7_28725630_28725928 0.07 CREB5
 cAMP responsive element binding protein 5
 181
 0.97
chr9_111396808_111397109 0.07 ACTL7B
 actin-like 7B
 222281
 0.02
chr11_93270941_93271177 0.07 SMCO4
 single-pass membrane protein with coiled-coil domains 4
 22
 0.98
chr11_1884799_1884950 0.07 LSP1
 lymphocyte-specific protein 1
 398
 0.51
chr2_70224516_70224667 0.07 PCBP1-AS1
 PCBP1 antisense RNA 1
 618
 0.69
chr5_158611818_158612659 0.07 RNF145
 ring finger protein 145
 22404
 0.16
chr20_48989399_48989550 0.07 ENSG00000244376
 .
 56546
 0.13
chr8_142137516_142137731 0.07 RP11-809O17.1
597
 0.62
chr4_166361643_166362016 0.07 CPE
 carboxypeptidase E
 22451
 0.23
chr3_151046365_151046540 0.07 P2RY13
 purinergic receptor P2Y, G-protein coupled, 13
 884
 0.57
chr1_42420201_42420352 0.07 HIVEP3
 human immunodeficiency virus type I enhancer binding protein 3
 35898
 0.22
chr10_106079197_106079348 0.07 RP11-127L20.5
7373
 0.13
chr6_34283894_34284092 0.06 C6orf1
 chromosome 6 open reading frame 1
 66746
 0.09
chr8_126308914_126309065 0.06 ENSG00000242170
 .
 26143
 0.21
chr2_37116896_37117561 0.06 ENSG00000252756
 .
 22590
 0.18
chr9_132579196_132579347 0.06 TOR1A
 torsin family 1, member A (torsin A)
 7142
 0.14
chr15_58624481_58624632 0.06 ALDH1A2
 aldehyde dehydrogenase 1 family, member A2
 53094
 0.15
chrX_109083591_109084037 0.06 ENSG00000252069
 .
 95836
 0.08
chr8_23399124_23399403 0.06 SLC25A37
 solute carrier family 25 (mitochondrial iron transporter), member 37
 12690
 0.16
chr4_74573765_74574020 0.06 IL8
 interleukin 8
 32331
 0.19
chr20_44439937_44440088 0.06 UBE2C
 ubiquitin-conjugating enzyme E2C
 1203
 0.27
chr16_89396583_89396806 0.06 ANKRD11
 ankyrin repeat domain 11
 1300
 0.35
chr11_67917703_67917854 0.06 CTD-2655K5.1
20513
 0.14
chr4_27985809_27985960 0.06 RP11-180C1.1
 Uncharacterized protein
 418439
 0.01
chr17_55945610_55945963 0.06 CUEDC1
 CUE domain containing 1
 1010
 0.52
chr18_21442082_21442233 0.06 LAMA3
 laminin, alpha 3
 10647
 0.22
chr2_143828948_143829099 0.06 ARHGAP15
 Rho GTPase activating protein 15
 19908
 0.24
chr1_161600101_161600252 0.06 FCGR3B
 Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
 646
 0.42
chr19_12899780_12900482 0.06 JUNB
 jun B proto-oncogene
 2179
 0.11
chr8_22921887_22922169 0.06 RP11-875O11.2
3714
 0.14
chrX_38728231_38728382 0.06 MID1IP1-AS1
 MID1IP1 antisense RNA 1
 65170
 0.13
chr4_10182968_10183393 0.06 WDR1
 WD repeat domain 1
 64607
 0.11
chr8_128310206_128310357 0.06 POU5F1B
 POU class 5 homeobox 1B
 116254
 0.07
chr1_159061696_159061989 0.06 AIM2
 absent in melanoma 2
 15151
 0.17
chr9_136037311_136037462 0.06 GBGT1
 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
 1896
 0.23
chr19_18526600_18526768 0.06 SSBP4
 single stranded DNA binding protein 4
 2990
 0.12
chr13_31270968_31271119 0.06 ALOX5AP
 arachidonate 5-lipoxygenase-activating protein
 38602
 0.18
chr4_105982370_105982725 0.06 ENSG00000252136
 .
 44597
 0.16
chr6_24950848_24950999 0.06 FAM65B
 family with sequence similarity 65, member B
 14735
 0.22
chr4_79473579_79473973 0.06 ANXA3
 annexin A3
 655
 0.79
chr4_87932888_87933250 0.06 AFF1
 AF4/FMR2 family, member 1
 4648
 0.31
chr21_28802590_28802741 0.06 ADAMTS5
 ADAM metallopeptidase with thrombospondin type 1 motif, 5
 463833
 0.01
chr3_101655473_101655624 0.06 ENSG00000202177
 .
 18373
 0.23
chr11_2395489_2395640 0.06 ENSG00000199550
 .
 1696
 0.2
chr15_89710840_89711060 0.06 RLBP1
 retinaldehyde binding protein 1
 44124
 0.12
chr15_37402275_37402801 0.06 MEIS2
 Meis homeobox 2
 9034
 0.23
chrX_130199798_130199949 0.06 ARHGAP36
 Rho GTPase activating protein 36
 7089
 0.23
chr11_85852849_85853000 0.06 ENSG00000200877
 .
 11345
 0.22
chr5_171279662_171279813 0.06 SMIM23
 small integral membrane protein 23
 66847
 0.11
chr17_27482435_27482735 0.06 RP11-321A17.4
15084
 0.15
chr1_95261518_95261669 0.06 SLC44A3
 solute carrier family 44, member 3
 24305
 0.19
chr7_127662588_127662739 0.06 LRRC4
 leucine rich repeat containing 4
 8395
 0.26
chr10_121031057_121031208 0.06 ENSG00000242853
 .
 58763
 0.09
chr1_6659470_6659968 0.06 KLHL21
 kelch-like family member 21
 157
 0.92
chr1_28502388_28502717 0.06 PTAFR
 platelet-activating factor receptor
 1147
 0.35
chr1_44985301_44985452 0.06 ENSG00000263381
 .
 25789
 0.18
chr6_13573909_13574318 0.06 SIRT5
 sirtuin 5
 713
 0.62
chr9_67026589_67026806 0.06 ENSG00000265285
 .
 68236
 0.13
chr12_57642712_57642903 0.06 STAC3
 SH3 and cysteine rich domain 3
 2160
 0.17
chr1_151579139_151579290 0.05 SNX27
 sorting nexin family member 27
 5344
 0.12
chr7_100070466_100070929 0.05 TSC22D4
 TSC22 domain family, member 4
 4998
 0.08
chr3_50658137_50658523 0.05 MAPKAPK3
 mitogen-activated protein kinase-activated protein kinase 3
 3509
 0.19
chr13_114830089_114831005 0.05 RASA3
 RAS p21 protein activator 3
 12891
 0.24
chr1_214649424_214649729 0.05 PTPN14
 protein tyrosine phosphatase, non-receptor type 14
 11430
 0.29
chr13_73634006_73635089 0.05 KLF5
 Kruppel-like factor 5 (intestinal)
 1617
 0.45
chr4_166256749_166256900 0.05 MSMO1
 methylsterol monooxygenase 1
 7745
 0.21
chr12_20522251_20522500 0.05 PDE3A
 phosphodiesterase 3A, cGMP-inhibited
 196
 0.89
chr15_99074007_99074158 0.05 FAM169B
 family with sequence similarity 169, member B
 16471
 0.27
chr6_35568962_35570321 0.05 ENSG00000212579
 .
 49954
 0.1
chr2_147579520_147579813 0.05 ENSG00000238860
 .
 501873
 0.0
chr15_91459213_91459364 0.05 MAN2A2
 mannosidase, alpha, class 2A, member 2
 3170
 0.11
chr12_6855415_6855566 0.05 MLF2
 myeloid leukemia factor 2
 6354
 0.08
chr22_37960000_37960286 0.05 CDC42EP1
 CDC42 effector protein (Rho GTPase binding) 1
 270
 0.86
chr3_132105351_132105502 0.05 DNAJC13
 DnaJ (Hsp40) homolog, subfamily C, member 13
 30944
 0.18
chr1_149369357_149369823 0.05 FCGR1C
 Fc fragment of IgG, high affinity Ic, receptor (CD64), pseudogene
 233
 0.9
chr22_35697778_35697929 0.05 TOM1
 target of myb1 (chicken)
 1966
 0.25
chr15_51633704_51634417 0.05 GLDN
 gliomedin
 234
 0.91
chr1_28189787_28189938 0.05 THEMIS2
 thymocyte selection associated family member 2
 9193
 0.11
chr1_226830744_226831144 0.05 ITPKB-IT1
 ITPKB intronic transcript 1 (non-protein coding)
 16427
 0.2
chr20_31888809_31889213 0.05 BPIFB1
 BPI fold containing family B, member 1
 18070
 0.15
chr9_37953977_37954130 0.05 ENSG00000251745
 .
 17288
 0.22
chr9_69655552_69655703 0.05 AL445665.1
 Protein LOC100996643
 5364
 0.29
chr6_109288373_109288524 0.05 RP11-787I22.3
31237
 0.15
chr10_101908565_101908716 0.05 ERLIN1
 ER lipid raft associated 1
 37146
 0.11
chr19_12893555_12894002 0.05 ENSG00000263800
 .
 4164
 0.08
chr19_4374737_4374888 0.05 SH3GL1
 SH3-domain GRB2-like 1
 5477
 0.08
chr2_218559547_218559837 0.05 DIRC3
 disrupted in renal carcinoma 3
 61586
 0.14
chr9_42853652_42853803 0.05 AC129778.2
2565
 0.39
chr3_194875945_194876317 0.05 XXYLT1-AS2
 XXYLT1 antisense RNA 2
 7511
 0.15
chr3_12504067_12504243 0.05 TSEN2
 TSEN2 tRNA splicing endonuclease subunit
 21776
 0.15
chr20_48909337_48909488 0.05 CEBPB
 CCAAT/enhancer binding protein (C/EBP), beta
 102036
 0.06
chr1_176180985_176181136 0.05 RP11-195C7.1
4276
 0.23
chr22_24903141_24903292 0.05 AP000355.2
9260
 0.13
chr4_166143196_166143347 0.05 KLHL2
 kelch-like family member 2
 2118
 0.32
chr2_64440045_64440196 0.05 AC074289.1
6011
 0.28
chr11_46697090_46697391 0.05 ATG13
 autophagy related 13
 11690
 0.13
chr18_57569513_57570014 0.05 PMAIP1
 phorbol-12-myristate-13-acetate-induced protein 1
 2515
 0.37
chr11_119583713_119583864 0.05 PVRL1
 poliovirus receptor-related 1 (herpesvirus entry mediator C)
 15475
 0.18
chr1_33807573_33808014 0.05 ENSG00000222112
 .
 5328
 0.13
chr19_1168749_1168988 0.05 SBNO2
 strawberry notch homolog 2 (Drosophila)
 74
 0.95
chr16_85096756_85096907 0.05 KIAA0513
 KIAA0513
 13
 0.98
chr14_70059974_70060446 0.05 KIAA0247
 KIAA0247
 18103
 0.2
chr5_96126813_96126964 0.05 CTD-2260A17.1
6224
 0.15
chr8_129262963_129263114 0.05 ENSG00000201782
 .
 30288
 0.23
chr3_112930660_112930893 0.05 BOC
 BOC cell adhesion associated, oncogene regulated
 266
 0.93
chr4_108745530_108746004 0.05 SGMS2
 sphingomyelin synthase 2
 48
 0.98
chrX_9881450_9881696 0.05 SHROOM2
 shroom family member 2
 850
 0.65
chr5_7676594_7676745 0.05 ADCY2
 adenylate cyclase 2 (brain)
 22605
 0.24
chr3_15310922_15311111 0.05 SH3BP5
 SH3-domain binding protein 5 (BTK-associated)
 6400
 0.15
chr3_42138838_42138989 0.05 TRAK1
 trafficking protein, kinesin binding 1
 6351
 0.29
chr9_114614096_114614247 0.05 ENSG00000206907
 .
 12063
 0.2
chr1_36816210_36816695 0.05 STK40
 serine/threonine kinase 40
 10489
 0.13
chr5_100113349_100113842 0.05 ENSG00000221263
 .
 38674
 0.19
chr6_18488896_18489181 0.05 ENSG00000207775
 .
 82977
 0.09
chr7_29153330_29153633 0.05 CPVL
 carboxypeptidase, vitellogenic-like
 97
 0.97
chr1_109373299_109373450 0.05 AKNAD1
 AKNA domain containing 1
 21965
 0.15
chr19_11449251_11449402 0.05 RAB3D
 RAB3D, member RAS oncogene family
 1018
 0.31
chr9_132251498_132251652 0.05 ENSG00000264298
 .
 10740
 0.21
chr19_39889302_39889453 0.05 MED29
 mediator complex subunit 29
 7325
 0.08
chr4_141077504_141077678 0.05 MAML3
 mastermind-like 3 (Drosophila)
 2253
 0.36
chr16_279128_279418 0.05 LUC7L
 LUC7-like (S. cerevisiae)
 148
 0.91
chr7_20824481_20824853 0.05 SP8
 Sp8 transcription factor
 1838
 0.51
chr8_11706405_11706556 0.05 RP11-589N15.2
2580
 0.22
chr9_6417233_6417502 0.05 UHRF2
 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
 3664
 0.25
chr19_11202980_11203131 0.05 LDLR
 low density lipoprotein receptor
 1780
 0.29
chr4_1716841_1717066 0.05 SLBP
 stem-loop binding protein
 2671
 0.19
chr7_102990167_102990648 0.05 PSMC2
 proteasome (prosome, macropain) 26S subunit, ATPase, 2
 2297
 0.25
chr15_92619299_92619450 0.05 RP11-24J19.1
96292
 0.09
chr6_42301055_42301206 0.05 ENSG00000221252
 .
 79004
 0.08
chr10_114746275_114746635 0.05 RP11-57H14.2
34821
 0.18
chr1_23912147_23912298 0.05 ID3
 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
 25937
 0.15
chr7_36603678_36603829 0.05 AOAH
 acyloxyacyl hydrolase (neutrophil)
 30509
 0.17
chr2_139274196_139274347 0.05 SPOPL
 speckle-type POZ protein-like
 14900
 0.31
chr5_6705329_6705480 0.05 PAPD7
 PAP associated domain containing 7
 9314
 0.26
chr6_14744303_14744454 0.05 ENSG00000206960
 .
 97612
 0.09
chr2_28177663_28177868 0.05 ENSG00000265321
 .
 41469
 0.15
chr12_54585165_54585441 0.04 SMUG1
 single-strand-selective monofunctional uracil-DNA glycosylase 1
 2525
 0.18
chrX_87167581_87167854 0.04 ENSG00000252016
 .
 236076
 0.02
chr12_3277666_3277860 0.04 TSPAN9-IT1
 TSPAN9 intronic transcript 1 (non-protein coding)
 18800
 0.21
chr10_35927790_35928179 0.04 ENSG00000264780
 .
 2196
 0.26
chr10_45872200_45872351 0.04 ALOX5
 arachidonate 5-lipoxygenase
 2600
 0.34
chr1_149754304_149754780 0.04 FCGR1A
 Fc fragment of IgG, high affinity Ia, receptor (CD64)
 296
 0.78
chr14_75590762_75591162 0.04 NEK9
 NIMA-related kinase 9
 2781
 0.19
chr2_173557887_173558038 0.04 ENSG00000239041
 .
 1935
 0.35
chr7_55620313_55620510 0.04 VOPP1
 vesicular, overexpressed in cancer, prosurvival protein 1
 134
 0.97
chr19_2169086_2169237 0.04 DOT1L
 DOT1-like histone H3K79 methyltransferase
 4977
 0.13
chr2_191278529_191278680 0.04 MFSD6
 major facilitator superfamily domain containing 6
 5523
 0.22
chr22_30642991_30643200 0.04 LIF
 leukemia inhibitory factor
 255
 0.78
chr19_49071767_49072143 0.04 SULT2B1
 sulfotransferase family, cytosolic, 2B, member 1
 6842
 0.11
chr11_64099501_64099713 0.04 AP003774.1
2631
 0.11
chr9_67293693_67293844 0.04 RP11-236F9.2
8470
 0.29
chr8_142141679_142142152 0.04 RP11-809O17.1
1855
 0.33
chrX_109124093_109124244 0.04 TMEM164
 transmembrane protein 164
 121695
 0.05
chr9_124044853_124045004 0.04 RP11-477J21.6
80
 0.96
chr15_43531850_43532099 0.04 ENSG00000202211
 .
 7904
 0.13
chr8_38856565_38856716 0.04 ADAM9
 ADAM metallopeptidase domain 9
 2135
 0.22
chr19_47853304_47853535 0.04 DHX34
 DEAH (Asp-Glu-Ala-His) box polypeptide 34
 881
 0.52
chrX_147691631_147691782 0.04 AFF2-IT1
 AFF2 intronic transcript 1 (non-protein coding)
 63307
 0.14
chr15_80452796_80453143 0.04 FAH
 fumarylacetoacetate hydrolase (fumarylacetoacetase)
 4676
 0.25
chr11_65667660_65668040 0.04 FOSL1
 FOS-like antigen 1
 40
 0.94
chr22_40832446_40832730 0.04 RP5-1042K10.13
21581
 0.14

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of FOSL1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0 0.1 GO:0051459 corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0 0.0 GO:0003181 atrioventricular valve development(GO:0003171) atrioventricular valve morphogenesis(GO:0003181)
0.0 0.0 GO:0002283 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 0.0 GO:0030210 heparin biosynthetic process(GO:0030210)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005827 polar microtubule(GO:0005827)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0019864 IgG binding(GO:0019864)
0.0 0.0 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.0 GO:0016362 activin receptor activity, type II(GO:0016362)
0.0 0.0 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)