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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for FOXA1

Z-value: 1.51

Motif logo

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Transcription factors associated with FOXA1

Gene Symbol Gene ID Gene Info
FOXA1
ENSG00000129514.4 forkhead box A1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr14_38016039_38016231FOXA1481040.1498010.713.3e-02Click!
chr14_38063381_38063532FOXA17830.6087970.655.9e-02Click!
chr14_38052851_38053204FOXA1112120.2252160.599.5e-02Click!
chr14_38063567_38064244FOXA13340.8354800.571.1e-01Click!
chr14_38068776_38069062FOXA13260.9056130.501.7e-01Click!

Activity of the FOXA1 motif across conditions

Conditions sorted by the z-value of the FOXA1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr21_28214648_28215240 0.97 ADAMTS1
 ADAM metallopeptidase with thrombospondin type 1 motif, 1
 393
 0.9
chr7_102470506_102470794 0.68 ENSG00000252643
 .
 4402
 0.21
chr4_48701412_48701950 0.68 FRYL
 FRY-like
 18493
 0.24
chr5_72746721_72747193 0.65 FOXD1
 forkhead box D1
 2605
 0.29
chr15_96878987_96879612 0.63 ENSG00000222651
 .
 2809
 0.21
chr1_61668583_61669016 0.63 RP4-802A10.1
78394
 0.11
chr4_81392876_81393298 0.62 C4orf22
 chromosome 4 open reading frame 22
 136164
 0.05
chr2_151334778_151334948 0.60 RND3
 Rho family GTPase 3
 7033
 0.34
chr3_124604600_124604823 0.58 ITGB5
 integrin, beta 5
 1433
 0.47
chr1_215179577_215179737 0.58 KCNK2
 potassium channel, subfamily K, member 2
 459
 0.91
chr2_230035602_230035855 0.57 PID1
 phosphotyrosine interaction domain containing 1
 61073
 0.14
chr8_125438541_125438825 0.56 TRMT12
 tRNA methyltransferase 12 homolog (S. cerevisiae)
 24365
 0.16
chr2_46165643_46166035 0.56 PRKCE
 protein kinase C, epsilon
 62202
 0.14
chr2_150418995_150419256 0.55 AC144449.1
24585
 0.19
chr2_190647319_190647470 0.53 ORMDL1
 ORM1-like 1 (S. cerevisiae)
 714
 0.49
chr6_17418741_17419244 0.52 CAP2
 CAP, adenylate cyclase-associated protein, 2 (yeast)
 25049
 0.25
chr12_59478573_59478971 0.52 RP11-150C16.1
164352
 0.04
chr7_27217405_27217623 0.51 RP1-170O19.20
 Uncharacterized protein
 2118
 0.1
chr2_38265076_38265999 0.51 RMDN2-AS1
 RMDN2 antisense RNA 1
 2053
 0.33
chr12_56920749_56920947 0.50 RBMS2
 RNA binding motif, single stranded interacting protein 2
 5065
 0.15
chr6_10426220_10426432 0.49 TFAP2A
 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
 6455
 0.18
chr6_53457738_53458227 0.48 GCLC
 glutamate-cysteine ligase, catalytic subunit
 23786
 0.17
chr3_100429715_100429877 0.48 TFG
 TRK-fused gene
 982
 0.64
chr4_123795073_123795451 0.48 RP11-170N16.3
10605
 0.18
chr15_33585949_33586454 0.48 RP11-489D6.2
16246
 0.22
chr6_151648337_151648657 0.47 AKAP12
 A kinase (PRKA) anchor protein 12
 1674
 0.27
chr10_25155972_25156509 0.46 ENSG00000240294
 .
 41501
 0.18
chr1_94701701_94701935 0.46 ARHGAP29
 Rho GTPase activating protein 29
 1303
 0.53
chr1_82267832_82267983 0.46 LPHN2
 latrophilin 2
 1825
 0.52
chr9_113799034_113800104 0.46 LPAR1
 lysophosphatidic acid receptor 1
 754
 0.74
chr2_133998643_133998815 0.45 AC010890.1
23811
 0.24
chr1_65363518_65363760 0.45 JAK1
 Janus kinase 1
 68548
 0.12
chr3_149865487_149865870 0.45 RP11-167H9.4
49859
 0.15
chr7_94025115_94025296 0.44 COL1A2
 collagen, type I, alpha 2
 1332
 0.57
chr1_168231073_168231252 0.44 ENSG00000206880
 .
 1557
 0.39
chr6_3825964_3826270 0.44 RP11-420L9.4
6050
 0.22
chr2_151336714_151337073 0.43 RND3
 Rho family GTPase 3
 5003
 0.36
chr5_103680813_103681290 0.43 ENSG00000239808
 .
 84524
 0.11
chr22_36841557_36841862 0.43 ENSG00000252225
 .
 4694
 0.17
chr12_48395931_48396147 0.42 COL2A1
 collagen, type II, alpha 1
 2065
 0.24
chr15_99864758_99865035 0.42 AC022819.2
 Uncharacterized protein
 5068
 0.23
chr6_138427325_138427625 0.42 PERP
 PERP, TP53 apoptosis effector
 1173
 0.59
chr18_52763849_52764148 0.42 ENSG00000252437
 .
 49878
 0.16
chr1_158087708_158088406 0.42 KIRREL
 kin of IRRE like (Drosophila)
 31587
 0.18
chr4_176922498_176923243 0.41 GPM6A
 glycoprotein M6A
 613
 0.78
chr6_125698814_125699135 0.41 RP11-735G4.1
3504
 0.35
chr7_41735925_41736162 0.41 INHBA-AS1
 INHBA antisense RNA 1
 2497
 0.29
chr21_45139141_45140358 0.41 PDXK
 pyridoxal (pyridoxine, vitamin B6) kinase
 756
 0.66
chr18_72509166_72509431 0.41 ZNF407
 zinc finger protein 407
 166322
 0.04
chr15_96869491_96869741 0.41 NR2F2
 nuclear receptor subfamily 2, group F, member 2
 449
 0.57
chr4_187857953_187858132 0.41 ENSG00000252382
 .
 79432
 0.12
chr8_42063953_42065062 0.41 PLAT
 plasminogen activator, tissue
 576
 0.71
chr4_124339787_124340099 0.41 SPRY1
 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
 18820
 0.3
chr3_167811230_167811432 0.40 GOLIM4
 golgi integral membrane protein 4
 1801
 0.51
chr3_161632471_161632704 0.40 OTOL1
 otolin 1
 417991
 0.01
chr11_121593168_121593875 0.40 SORL1
 sortilin-related receptor, L(DLR class) A repeats containing
 132393
 0.05
chr2_150186573_150186784 0.40 LYPD6
 LY6/PLAUR domain containing 6
 179
 0.97
chr12_115174256_115174747 0.40 ENSG00000252459
 .
 1008
 0.64
chr18_57332899_57333095 0.40 CCBE1
 collagen and calcium binding EGF domains 1
 397
 0.86
chr5_162992519_162993506 0.40 MAT2B
 methionine adenosyltransferase II, beta
 60392
 0.11
chr6_104981791_104982069 0.39 ENSG00000252944
 .
 232767
 0.02
chr6_121758735_121759079 0.39 GJA1
 gap junction protein, alpha 1, 43kDa
 2069
 0.31
chr1_216773992_216774229 0.39 ESRRG
 estrogen-related receptor gamma
 122564
 0.06
chr1_185703938_185704134 0.39 HMCN1
 hemicentin 1
 353
 0.92
chrX_10737482_10738236 0.39 MID1
 midline 1 (Opitz/BBB syndrome)
 92080
 0.1
chr2_66723532_66723851 0.39 MEIS1
 Meis homeobox 1
 12368
 0.22
chr7_79081974_79082229 0.39 ENSG00000234456
 .
 97
 0.92
chr3_114477226_114477377 0.38 ZBTB20
 zinc finger and BTB domain containing 20
 486
 0.86
chr4_145570819_145570970 0.38 HHIP
 hedgehog interacting protein
 3570
 0.28
chr10_13931045_13931263 0.38 FRMD4A
 FERM domain containing 4A
 30242
 0.2
chr21_32591500_32591929 0.38 TIAM1
 T-cell lymphoma invasion and metastasis 1
 57369
 0.16
chr4_187648403_187648661 0.38 FAT1
 FAT atypical cadherin 1
 656
 0.82
chr9_33506853_33507187 0.38 RP11-255A11.2
7751
 0.17
chr1_92317111_92317363 0.38 TGFBR3
 transforming growth factor, beta receptor III
 9913
 0.22
chr5_140801311_140801579 0.37 PCDHGA11
 protocadherin gamma subfamily A, 11
 650
 0.41
chr7_97952929_97953353 0.37 RP11-307C18.1
976
 0.55
chr5_91888200_91888432 0.37 ENSG00000264489
 .
 146572
 0.05
chr10_29824157_29824642 0.37 ENSG00000207612
 .
 9627
 0.19
chr6_45523679_45523878 0.36 ENSG00000252738
 .
 90063
 0.09
chr3_47155829_47156131 0.36 ENSG00000251938
 .
 25882
 0.16
chr2_216296824_216297216 0.36 FN1
 fibronectin 1
 3770
 0.26
chr15_100583304_100583570 0.36 ENSG00000252957
 .
 30958
 0.16
chr11_16023597_16024065 0.36 CTD-3096P4.1
20905
 0.28
chr6_113994010_113994191 0.36 ENSG00000221559
 .
 31935
 0.2
chr1_172154318_172154604 0.36 DNM3OS
 DNM3 opposite strand/antisense RNA
 40527
 0.14
chr3_145879077_145879748 0.36 PLOD2
 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
 458
 0.86
chr4_157868586_157868737 0.36 PDGFC
 platelet derived growth factor C
 23394
 0.2
chr4_184369530_184369754 0.35 CDKN2AIP
 CDKN2A interacting protein
 3792
 0.23
chr4_169491131_169491310 0.35 PALLD
 palladin, cytoskeletal associated protein
 58501
 0.12
chr8_39939130_39939407 0.35 C8orf4
 chromosome 8 open reading frame 4
 71721
 0.11
chr4_75175100_75175487 0.35 EPGN
 epithelial mitogen
 479
 0.82
chr16_72325870_72326093 0.35 ENSG00000207514
 .
 84622
 0.08
chr1_101754265_101754416 0.35 RP4-575N6.5
45626
 0.13
chr3_16218692_16218887 0.35 GALNT15
 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
 2573
 0.36
chr9_111034250_111034449 0.34 ENSG00000222512
 .
 86860
 0.1
chr1_205270236_205270504 0.34 NUAK2
 NUAK family, SNF1-like kinase, 2
 20513
 0.15
chr22_40706246_40706565 0.34 ADSL
 adenylosuccinate lyase
 36102
 0.14
chr13_36049085_36049236 0.34 MAB21L1
 mab-21-like 1 (C. elegans)
 1672
 0.32
chr7_30637504_30637655 0.34 ENSG00000196295
 .
 3154
 0.23
chr13_73712912_73713063 0.34 ENSG00000265959
 .
 14040
 0.19
chr6_157274340_157274740 0.34 ARID1B
 AT rich interactive domain 1B (SWI1-like)
 52033
 0.17
chr12_66089013_66089164 0.33 HMGA2
 high mobility group AT-hook 2
 128823
 0.05
chr3_124605343_124605563 0.33 ITGB5
 integrin, beta 5
 691
 0.74
chr18_74237053_74237772 0.33 LINC00908
 long intergenic non-protein coding RNA 908
 3200
 0.24
chr1_86045810_86046121 0.33 CYR61
 cysteine-rich, angiogenic inducer, 61
 479
 0.77
chr6_128828666_128828900 0.33 RP1-86D1.4
2513
 0.24
chr12_15038397_15038786 0.33 MGP
 matrix Gla protein
 200
 0.92
chr12_16762141_16762326 0.33 LMO3
 LIM domain only 3 (rhombotin-like 2)
 573
 0.83
chr13_103382043_103382374 0.33 CCDC168
 coiled-coil domain containing 168
 6951
 0.13
chr4_41217997_41218148 0.33 APBB2
 amyloid beta (A4) precursor protein-binding, family B, member 2
 1437
 0.44
chr5_151062319_151062545 0.33 SPARC
 secreted protein, acidic, cysteine-rich (osteonectin)
 2359
 0.22
chr6_82755621_82755792 0.33 ENSG00000223044
 .
 164451
 0.04
chr8_49468858_49469448 0.33 RP11-770E5.1
5026
 0.35
chr12_76653631_76654077 0.33 ENSG00000223273
 .
 55677
 0.14
chr7_73671230_73671468 0.32 ENSG00000252538
 .
 1597
 0.31
chr5_73110322_73110752 0.32 ARHGEF28
 Rho guanine nucleotide exchange factor (GEF) 28
 1194
 0.51
chr12_13350846_13351208 0.32 EMP1
 epithelial membrane protein 1
 1307
 0.55
chr13_76278728_76279091 0.32 LMO7
 LIM domain 7
 55594
 0.13
chr12_13025379_13025989 0.32 GPRC5A
 G protein-coupled receptor, family C, group 5, member A
 18032
 0.14
chr6_157639179_157639343 0.32 ENSG00000252609
 .
 73170
 0.11
chr8_48571824_48572102 0.32 SPIDR
 scaffolding protein involved in DNA repair
 263
 0.93
chr1_24621056_24621364 0.32 ENSG00000266511
 .
 14865
 0.15
chr2_20643812_20644209 0.31 RHOB
 ras homolog family member B
 2825
 0.27
chr19_31714740_31714922 0.31 AC020952.1
 Uncharacterized protein
 74469
 0.12
chr3_98613191_98613556 0.31 DCBLD2
 discoidin, CUB and LCCL domain containing 2
 6642
 0.19
chr2_145188780_145188931 0.31 ZEB2
 zinc finger E-box binding homeobox 2
 718
 0.79
chr7_121170130_121170295 0.31 ENSG00000221690
 .
 44596
 0.19
chr6_143995099_143995343 0.31 PHACTR2
 phosphatase and actin regulator 2
 3881
 0.32
chr1_86078649_86078931 0.31 ENSG00000199934
 .
 20827
 0.18
chr1_107684305_107684780 0.31 NTNG1
 netrin G1
 881
 0.74
chr1_214397865_214398571 0.31 SMYD2
 SET and MYND domain containing 2
 56358
 0.16
chr5_92917804_92917955 0.31 ENSG00000237187
 .
 876
 0.48
chr1_158969050_158969253 0.31 IFI16
 interferon, gamma-inducible protein 16
 607
 0.76
chr20_22384501_22385014 0.31 FOXA2
 forkhead box A2
 180344
 0.03
chr3_109884338_109884502 0.31 ENSG00000221206
 .
 386392
 0.01
chr13_101202971_101203237 0.31 RP11-151A6.4
11044
 0.19
chr5_112398331_112398555 0.30 DCP2
 decapping mRNA 2
 85964
 0.08
chr17_7515414_7515712 0.30 ENSG00000251860
 .
 1064
 0.18
chr4_174102838_174102989 0.30 RP11-10K16.1
12110
 0.19
chr6_52217103_52217563 0.30 PAQR8
 progestin and adipoQ receptor family member VIII
 8886
 0.23
chr11_91714959_91715138 0.30 FAT3
 FAT atypical cadherin 3
 370214
 0.01
chr2_106260790_106261225 0.30 NCK2
 NCK adaptor protein 2
 100347
 0.08
chr2_205411353_205411504 0.30 PARD3B
 par-3 family cell polarity regulator beta
 705
 0.83
chr11_92029031_92029279 0.30 FAT3
 FAT atypical cadherin 3
 56107
 0.17
chr5_132385315_132385509 0.30 HSPA4
 heat shock 70kDa protein 4
 2242
 0.29
chr9_14423961_14424182 0.30 NFIB
 nuclear factor I/B
 25089
 0.25
chr15_63178723_63178874 0.30 RP11-1069G10.1
2565
 0.34
chr12_42978890_42979099 0.30 PRICKLE1
 prickle homolog 1 (Drosophila)
 4484
 0.31
chr10_24752381_24752532 0.30 KIAA1217
 KIAA1217
 3004
 0.32
chr12_19591912_19592176 0.30 AEBP2
 AE binding protein 2
 564
 0.8
chr12_50608566_50608717 0.30 RP3-405J10.4
4746
 0.13
chr17_2308923_2309089 0.29 MNT
 MAX network transcriptional repressor
 4594
 0.13
chr2_1734119_1734469 0.29 PXDN
 peroxidasin homolog (Drosophila)
 13920
 0.26
chr3_152046405_152046556 0.29 TMEM14E
 transmembrane protein 14E
 12299
 0.22
chr13_36048764_36048946 0.29 MAB21L1
 mab-21-like 1 (C. elegans)
 1977
 0.3
chr1_203159153_203159304 0.29 CHI3L1
 chitinase 3-like 1 (cartilage glycoprotein-39)
 3351
 0.18
chr2_36924555_36924939 0.29 VIT
 vitrin
 727
 0.75
chr17_8976227_8976400 0.29 NTN1
 netrin 1
 50693
 0.15
chr17_45982661_45983102 0.29 SP2
 Sp2 transcription factor
 9365
 0.1
chr3_197021883_197022040 0.29 ENSG00000265850
 .
 1142
 0.4
chr4_2960219_2960405 0.29 NOP14
 NOP14 nucleolar protein
 4748
 0.16
chr6_148762563_148762871 0.29 ENSG00000223322
 .
 82659
 0.1
chr9_110253387_110253828 0.29 KLF4
 Kruppel-like factor 4 (gut)
 844
 0.66
chr8_29027576_29027748 0.29 ENSG00000264328
 .
 27452
 0.15
chr4_182568542_182568740 0.28 ENSG00000251742
 .
 187620
 0.03
chr14_50787669_50787839 0.28 ATP5S
 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
 1802
 0.29
chr5_3600517_3600892 0.28 CTD-2012M11.3
402
 0.89
chr16_87098321_87098755 0.28 RP11-899L11.3
150983
 0.04
chr3_16217443_16217716 0.28 GALNT15
 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
 1363
 0.53
chr4_169770371_169770556 0.28 RP11-635L1.3
16375
 0.18
chr20_1103594_1103745 0.28 PSMF1
 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
 4389
 0.25
chr6_141884450_141884959 0.28 ENSG00000222764
 .
 77155
 0.13
chr14_29228686_29229081 0.28 RP11-966I7.1
5586
 0.17
chr2_102383869_102384043 0.28 MAP4K4
 mitogen-activated protein kinase kinase kinase kinase 4
 29770
 0.24
chr4_87503159_87503484 0.28 MAPK10
 mitogen-activated protein kinase 10
 11942
 0.21
chr5_131893791_131893942 0.28 RAD50
 RAD50 homolog (S. cerevisiae)
 943
 0.42
chr22_43166170_43166377 0.28 ENSG00000200448
 .
 7308
 0.21
chr7_2842191_2842738 0.28 GNA12
 guanine nucleotide binding protein (G protein) alpha 12
 12428
 0.25
chr21_17442999_17443232 0.28 ENSG00000252273
 .
 35286
 0.24
chr4_77067485_77067636 0.27 NUP54
 nucleoporin 54kDa
 1990
 0.3
chr3_29388286_29388437 0.27 ENSG00000216169
 .
 22551
 0.22
chr1_81703498_81704139 0.27 ENSG00000223026
 .
 13656
 0.28
chr2_180293372_180293844 0.27 ZNF385B
 zinc finger protein 385B
 133707
 0.05
chr5_65097013_65097416 0.27 NLN
 neurolysin (metallopeptidase M3 family)
 13024
 0.24
chr6_4059667_4059856 0.27 ENSG00000252668
 .
 16862
 0.13
chr9_97951408_97952029 0.27 ENSG00000238746
 .
 16838
 0.19
chr4_134071254_134071890 0.27 PCDH10
 protocadherin 10
 1102
 0.7
chr2_174495860_174496019 0.27 CDCA7
 cell division cycle associated 7
 276339
 0.01
chr12_132316032_132316383 0.27 MMP17
 matrix metallopeptidase 17 (membrane-inserted)
 3122
 0.22
chr3_11267791_11267952 0.27 HRH1
 histamine receptor H1
 154
 0.97
chr2_63416100_63416251 0.27 OTX1
 orthodenticle homeobox 1
 138238
 0.05
chr5_111016644_111016835 0.27 ENSG00000253057
 .
 39019
 0.16
chr20_60163995_60164193 0.27 CDH4
 cadherin 4, type 1, R-cadherin (retinal)
 10740
 0.3
chr13_110957687_110957838 0.27 COL4A2
 collagen, type IV, alpha 2
 397
 0.84
chr4_124981640_124982053 0.27 ANKRD50
 ankyrin repeat domain 50
 652041
 0.0
chr18_73167828_73168275 0.26 SMIM21
 small integral membrane protein 21
 28393
 0.22
chr1_218337432_218337583 0.26 ENSG00000201493
 .
 34370
 0.22
chr8_35235141_35235292 0.26 UNC5D
 unc-5 homolog D (C. elegans)
 141923
 0.05
chr2_199480864_199481015 0.26 ENSG00000252511
 .
 49486
 0.2
chr15_96886136_96886425 0.26 ENSG00000222651
 .
 9790
 0.16

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXA1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.2 0.6 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.2 0.2 GO:0060841 venous blood vessel development(GO:0060841)
0.2 1.1 GO:0060347 heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.1 0.3 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 0.4 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.1 0.2 GO:0042816 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.1 0.2 GO:0030210 heparin biosynthetic process(GO:0030210)
0.1 0.4 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.1 0.3 GO:0008218 bioluminescence(GO:0008218)
0.1 0.2 GO:0061364 apoptotic process involved in luteolysis(GO:0061364)
0.1 0.3 GO:0043589 skin morphogenesis(GO:0043589)
0.1 0.3 GO:0072268 pattern specification involved in metanephros development(GO:0072268)
0.1 0.2 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.1 0.2 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 0.2 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.1 0.2 GO:0031223 auditory behavior(GO:0031223)
0.1 0.2 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1 0.2 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.1 0.2 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 0.5 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.1 0.2 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.1 0.1 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
0.1 0.1 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.0 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.3 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0 0.1 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.0 0.3 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0 0.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.0 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0 0.1 GO:0042637 catagen(GO:0042637)
0.0 0.2 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.1 GO:0072071 mesangial cell differentiation(GO:0072007) kidney interstitial fibroblast differentiation(GO:0072071) renal interstitial fibroblast development(GO:0072141) mesangial cell development(GO:0072143) pericyte cell differentiation(GO:1904238)
0.0 0.1 GO:0003171 atrioventricular valve development(GO:0003171) atrioventricular valve morphogenesis(GO:0003181)
0.0 0.3 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.1 GO:0051176 positive regulation of sulfur metabolic process(GO:0051176)
0.0 0.1 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.3 GO:0009629 response to gravity(GO:0009629)
0.0 0.1 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272) embryonic skeletal joint development(GO:0072498)
0.0 0.2 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.2 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.1 GO:0051503 adenine nucleotide transport(GO:0051503)
0.0 0.1 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.0 0.1 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.0 0.3 GO:0032330 regulation of chondrocyte differentiation(GO:0032330)
0.0 0.2 GO:0035413 positive regulation of catenin import into nucleus(GO:0035413)
0.0 0.2 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.1 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.0 0.4 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.1 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.0 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.1 GO:0003032 detection of oxygen(GO:0003032)
0.0 0.0 GO:0060449 bud elongation involved in lung branching(GO:0060449)
0.0 0.1 GO:0060900 embryonic camera-type eye formation(GO:0060900)
0.0 0.1 GO:0001547 antral ovarian follicle growth(GO:0001547)
0.0 0.0 GO:2000696 nephron tubule epithelial cell differentiation(GO:0072160) regulation of nephron tubule epithelial cell differentiation(GO:0072182) regulation of epithelial cell differentiation involved in kidney development(GO:2000696)
0.0 0.2 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0000019 regulation of mitotic recombination(GO:0000019)
0.0 0.3 GO:0001502 cartilage condensation(GO:0001502) cell aggregation(GO:0098743)
0.0 0.0 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.1 GO:0015959 diadenosine polyphosphate metabolic process(GO:0015959)
0.0 0.0 GO:0021831 embryonic olfactory bulb interneuron precursor migration(GO:0021831)
0.0 0.1 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0 0.1 GO:0071801 regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0 0.1 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.0 GO:1901534 positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0 0.2 GO:0031529 ruffle organization(GO:0031529)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.1 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.0 0.0 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.0 0.0 GO:0060242 contact inhibition(GO:0060242)
0.0 0.1 GO:0015802 basic amino acid transport(GO:0015802)
0.0 0.0 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.1 GO:0030859 polarized epithelial cell differentiation(GO:0030859) establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0 0.1 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003)
0.0 0.0 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.0 0.1 GO:1903672 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.0 0.1 GO:0006533 aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.0 0.2 GO:0043113 receptor clustering(GO:0043113)
0.0 0.1 GO:0007008 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.0 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0 0.0 GO:0010661 positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0 0.1 GO:0010159 specification of organ position(GO:0010159)
0.0 0.1 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.0 0.1 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.2 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.0 0.0 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.0 GO:0021898 commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0 0.0 GO:0060433 bronchus development(GO:0060433)
0.0 0.1 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0 0.1 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.1 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.1 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:0032261 purine nucleotide salvage(GO:0032261)
0.0 0.2 GO:0045749 obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0 0.1 GO:0008354 germ cell migration(GO:0008354)
0.0 0.1 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.1 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.0 0.0 GO:1902745 positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0 0.0 GO:0072189 positive regulation of smooth muscle cell differentiation(GO:0051152) ureter development(GO:0072189) ureter smooth muscle development(GO:0072191) ureter smooth muscle cell differentiation(GO:0072193) kidney smooth muscle tissue development(GO:0072194)
0.0 0.3 GO:0042730 fibrinolysis(GO:0042730)
0.0 0.0 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.0 GO:0072033 renal vesicle formation(GO:0072033)
0.0 0.0 GO:0001738 morphogenesis of a polarized epithelium(GO:0001738)
0.0 0.1 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.1 GO:0035437 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0 0.0 GO:0032898 neurotrophin production(GO:0032898)
0.0 0.2 GO:0048701 embryonic cranial skeleton morphogenesis(GO:0048701)
0.0 0.0 GO:0003161 cardiac conduction system development(GO:0003161)
0.0 0.0 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.0 GO:0021542 dentate gyrus development(GO:0021542)
0.0 0.1 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.0 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.0 0.3 GO:0001755 neural crest cell migration(GO:0001755)
0.0 0.0 GO:0000966 RNA 5'-end processing(GO:0000966)
0.0 0.0 GO:0021754 facial nucleus development(GO:0021754)
0.0 0.1 GO:0007494 midgut development(GO:0007494)
0.0 0.0 GO:0018242 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.1 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.0 0.1 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.0 GO:2000794 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.0 0.1 GO:0031272 pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.1 GO:0042249 establishment of planar polarity of embryonic epithelium(GO:0042249)
0.0 0.1 GO:0002052 positive regulation of neuroblast proliferation(GO:0002052)
0.0 0.2 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.0 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.0 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.1 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.0 GO:1900116 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.1 GO:0016540 protein autoprocessing(GO:0016540)
0.0 0.0 GO:0000492 small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0 0.0 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.0 GO:0051140 regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.1 GO:0032528 microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0 0.0 GO:0021615 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.0 GO:0003170 heart valve development(GO:0003170) heart valve morphogenesis(GO:0003179)
0.0 0.0 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.0 0.0 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.0 GO:0001880 Mullerian duct regression(GO:0001880)
0.0 0.1 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.0 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.0 GO:0009106 lipoate metabolic process(GO:0009106)
0.0 0.0 GO:0050651 dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0 0.0 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0 0.0 GO:0090049 regulation of cell migration involved in sprouting angiogenesis(GO:0090049) regulation of sprouting angiogenesis(GO:1903670)
0.0 0.0 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.0 0.0 GO:0045992 negative regulation of embryonic development(GO:0045992)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0071437 invadopodium(GO:0071437)
0.1 0.4 GO:0005606 laminin-1 complex(GO:0005606)
0.0 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.3 GO:0008091 spectrin(GO:0008091)
0.0 0.2 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.4 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0030673 axolemma(GO:0030673)
0.0 0.0 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.2 GO:0001527 microfibril(GO:0001527)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 1.6 GO:0005604 basement membrane(GO:0005604)
0.0 0.2 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.4 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.0 GO:0014704 intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0 0.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.1 GO:0098644 collagen type VI trimer(GO:0005589) complex of collagen trimers(GO:0098644) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.5 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.1 GO:0008274 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0 0.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.2 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.1 GO:0005916 fascia adherens(GO:0005916)
0.0 0.0 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.3 GO:0045178 basal part of cell(GO:0045178)
0.0 0.0 GO:0002141 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0 0.0 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.0 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.4 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.2 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.2 GO:0030057 desmosome(GO:0030057)
0.0 0.1 GO:0030128 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0 0.0 GO:0001652 granular component(GO:0001652)
0.0 0.1 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.0 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.0 GO:0070552 BRISC complex(GO:0070552)
0.0 0.1 GO:0032389 MutLalpha complex(GO:0032389)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.1 0.7 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.1 0.2 GO:0042577 lipid phosphatase activity(GO:0042577)
0.1 0.2 GO:0001098 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1 0.5 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 0.2 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.2 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.1 0.3 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 0.2 GO:0045499 chemorepellent activity(GO:0045499)
0.1 0.2 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 0.4 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.3 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.2 GO:0030955 potassium ion binding(GO:0030955)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.1 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.2 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.0 0.1 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.2 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.2 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.1 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.3 GO:0001619 obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0 0.2 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.2 GO:0008494 translation activator activity(GO:0008494)
0.0 0.2 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.1 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.1 GO:0016151 nickel cation binding(GO:0016151)
0.0 0.1 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.1 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0 0.2 GO:0030553 cGMP binding(GO:0030553)
0.0 0.1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.1 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.1 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.0 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.1 GO:0016623 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0 0.1 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.2 GO:0043498 obsolete cell surface binding(GO:0043498)
0.0 0.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.1 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.0 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0 0.1 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.0 0.0 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.0 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.0 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.1 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.0 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.0 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.0 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.0 GO:0046848 hydroxyapatite binding(GO:0046848)
0.0 0.0 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.1 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.0 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.0 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.0 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0 0.3 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.0 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.1 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.0 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.1 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.1 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.0 GO:0004946 bombesin receptor activity(GO:0004946)
0.0 0.0 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.1 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.0 0.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.2 GO:0030971 receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782)
0.0 0.0 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.2 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.0 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.0 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.6 GO:0005178 integrin binding(GO:0005178)
0.0 0.4 GO:0004629 phospholipase C activity(GO:0004629)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 1.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.5 GO:0030165 PDZ domain binding(GO:0030165)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.9 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.8 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.1 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.1 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.4 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.1 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.3 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.1 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.1 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.2 ST G ALPHA S PATHWAY G alpha s Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME DAG AND IP3 SIGNALING Genes involved in DAG and IP3 signaling
0.0 0.5 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.2 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.1 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.0 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.3 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.0 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.0 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 0.5 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.2 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.3 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.1 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.1 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.2 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.1 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.0 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.2 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.1 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.0 REACTOME SHC RELATED EVENTS Genes involved in SHC-related events
0.0 0.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.3 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.3 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.1 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex