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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for FOXC1

Z-value: 0.81

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Transcription factors associated with FOXC1

Gene Symbol	Gene ID	Gene Info
FOXC1 Ensembl NCBI GeneCards UniProt	ENSG00000054598.5	FOXC1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
FOXC1	chr6_1885704_1885932	275137	0.014966	0.70	3.7e-02	Click!
FOXC1	chr6_1703862_1704013	93256	0.093857	-0.58	1.0e-01	Click!
FOXC1	chr6_1617814_1617965	7208	0.314162	0.57	1.1e-01	Click!
FOXC1	chr6_1615364_1615572	4787	0.336813	0.56	1.1e-01	Click!
FOXC1	chr6_1610269_1610509	292	0.947549	0.56	1.2e-01	Click!

Activity of the FOXC1 motif across conditions

Conditions sorted by the z-value of the FOXC1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chrX_16826274_16826456	0.43	TXLNG	taxilin gamma	21810	0.16
chr7_6521360_6521521	0.39	FLJ20306	CDNA FLJ20306 fis, clone HEP06881; Putative uncharacterized protein FLJ20306; Uncharacterized protein	1482	0.28
chr11_82828119_82828301	0.39	PCF11	PCF11 cleavage and polyadenylation factor subunit	39820	0.12
chr11_3400503_3400805	0.35	ZNF195	zinc finger protein 195	206	0.92
chr8_27631557_27631733	0.34	ESCO2	establishment of sister chromatid cohesion N-acetyltransferase 2	258	0.66
chr8_77911562_77912296	0.33	PEX2	peroxisomal biogenesis factor 2	533	0.85
chr9_71590240_71590555	0.32	PRKACG	protein kinase, cAMP-dependent, catalytic, gamma	38642	0.15
chr7_84154352_84154503	0.28	SEMA3A	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	32387	0.25
chr11_92930195_92930700	0.27	SLC36A4	solute carrier family 36 (proton/amino acid symporter), member 4	174	0.97
chr1_98369641_98369792	0.26	DPYD	dihydropyrimidine dehydrogenase	16837	0.28
chr6_1612835_1613496	0.26	FOXC1	forkhead box C1	2484	0.42
chr11_119076374_119076525	0.25	CBL	Cbl proto-oncogene, E3 ubiquitin protein ligase	303	0.81
chr12_75876585_75876939	0.25	GLIPR1	GLI pathogenesis-related 1	1778	0.34
chr4_129557030_129557181	0.25	ENSG00000238802	.	120076	0.06
chr11_46615706_46615915	0.24	AMBRA1	autophagy/beclin-1 regulator 1	135	0.96
chr10_50649676_50649900	0.23	RP11-123B3.2		22465	0.17
chr12_72667945_72668096	0.23	ENSG00000236333	.	667	0.5
chr14_31879360_31879511	0.23	HEATR5A	HEAT repeat containing 5A	7254	0.17
chr8_13730073_13730224	0.23	RP11-145O15.3		268029	0.02
chr15_76629589_76629763	0.22	ISL2	ISL LIM homeobox 2	611	0.74
chrX_15934152_15934303	0.21	ENSG00000200566	.	199	0.96
chr15_91955379_91955670	0.21	SV2B	synaptic vesicle glycoprotein 2B	186424	0.03
chr6_116833589_116833880	0.21	TRAPPC3L	trafficking protein particle complex 3-like	228	0.83
chr19_2095175_2095486	0.21	MOB3A	MOB kinase activator 3A	939	0.33
chr2_113012718_113012869	0.21	ZC3H8	zinc finger CCCH-type containing 8	105	0.97
chr10_91061669_91062419	0.20	IFIT2	interferon-induced protein with tetratricopeptide repeats 2	332	0.85
chrY_9925657_9925808	0.20	ENSG00000251766	.	2405	0.28
chr16_2570012_2570182	0.20	AMDHD2	amidohydrolase domain containing 2	261	0.71
chr11_46141542_46141818	0.20	PHF21A	PHD finger protein 21A	267	0.92
chrX_18456912_18457063	0.20	CDKL5	cyclin-dependent kinase-like 5	3321	0.31
chr11_104576737_104577140	0.20	CASP12	caspase 12 (gene/pseudogene)	192203	0.03
chr1_28832516_28832718	0.19	RCC1	regulator of chromosome condensation 1	48	0.94
chr10_8203120_8203271	0.19	GATA3	GATA binding protein 3	106426	0.08
chr2_72376882_72377179	0.19	CYP26B1	cytochrome P450, family 26, subfamily B, polypeptide 1	1863	0.53
chr5_158407500_158407684	0.19	CTD-2363C16.1		2422	0.33
chr6_2876062_2876267	0.19	ENSG00000266750	.	21823	0.15
chr4_10691726_10691877	0.19	CLNK	cytokine-dependent hematopoietic cell linker	5312	0.35
chr1_39324368_39325146	0.19	RRAGC	Ras-related GTP binding C	738	0.44
chr5_56124620_56124771	0.19	MAP3K1	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	13294	0.17
chr11_15919049_15919200	0.18	CTD-3096P4.1		125612	0.06
chr7_147748643_147748794	0.18	CNTNAP2	contactin associated protein-like 2	82058	0.1
chr19_4114935_4115086	0.18	MAP2K2	mitogen-activated protein kinase kinase 2	9104	0.12
chr4_169075013_169075164	0.18	RP11-310I9.1		40606	0.17
chr18_21032782_21033062	0.18	RIOK3	RIO kinase 3	135	0.95
chr2_61372387_61372598	0.18	C2orf74	chromosome 2 open reading frame 74	249	0.92
chr5_17255187_17255338	0.18	ENSG00000252908	.	14542	0.19
chr6_132833581_132834005	0.18	STX7	syntaxin 7	408	0.85
chr14_52116783_52117087	0.17	FRMD6	FERM domain containing 6	1641	0.39
chr6_156086673_156086824	0.17	ENSG00000238789	.	110588	0.07
chr11_57529774_57530544	0.17	CTNND1	catenin (cadherin-associated protein), delta 1	869	0.5
chr4_7937771_7938061	0.17	AC097381.1		2812	0.26
chr8_126444680_126445315	0.17	TRIB1	tribbles pseudokinase 1	546	0.81
chr12_91574306_91575101	0.17	DCN	decorin	50	0.99
chr19_19932661_19932812	0.17	ZNF506	zinc finger protein 506	176	0.93
chr5_82672808_82672959	0.17	VCAN	versican	94401	0.09
chr12_77626162_77626313	0.17	ENSG00000238769	.	69432	0.14
chr14_61190612_61190839	0.17	SIX4	SIX homeobox 4	127	0.97
chr19_42985275_42985426	0.17	ENSG00000253048	.	8323	0.14
chr14_75744052_75744985	0.16	FOS	FBJ murine osteosarcoma viral oncogene homolog	959	0.51
chr7_116775065_116775216	0.16	ST7-AS2	ST7 antisense RNA 2	10472	0.23
chr14_37463384_37463535	0.16	ENSG00000266327	.	41863	0.18
chr7_24608273_24608424	0.16	MPP6	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	4539	0.29
chr20_17005032_17005183	0.16	ENSG00000212165	.	41429	0.2
chr10_63855843_63855994	0.16	ENSG00000221094	.	20056	0.23
chr3_79778551_79778702	0.16	ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)	38339	0.23
chr13_24841248_24841663	0.16	SPATA13	spermatogenesis associated 13	3371	0.21
chr5_54157434_54157674	0.16	ENSG00000221073	.	8778	0.26
chr1_64977055_64977206	0.16	CACHD1	cache domain containing 1	40655	0.18
chr5_369067_369218	0.16	AHRR	aryl-hydrocarbon receptor repressor	25499	0.15
chr18_47793998_47794618	0.16	CCDC11	coiled-coil domain containing 11	1416	0.36
chr2_216293163_216293314	0.16	FN1	fibronectin 1	7552	0.23
chr8_59466247_59466777	0.16	SDCBP	syndecan binding protein (syntenin)	698	0.76
chr7_134287566_134287824	0.16	AKR1B15	aldo-keto reductase family 1, member B15	37462	0.17
chr1_28879171_28879359	0.16	TRNAU1AP	tRNA selenocysteine 1 associated protein 1	332	0.8
chr15_64923415_64923566	0.16	ENSG00000207223	.	21597	0.14
chr9_128484739_128484890	0.16	MAPKAP1	mitogen-activated protein kinase associated protein 1	15301	0.23
chr8_42005635_42005786	0.16	RP11-589C21.5		4571	0.19
chr22_17697616_17697767	0.16	CECR1	cat eye syndrome chromosome region, candidate 1	2575	0.29
chr13_27825183_27825382	0.15	RPL21	ribosomal protein L21	164	0.92
chr19_16347709_16347860	0.15	AP1M1	adaptor-related protein complex 1, mu 1 subunit	9368	0.15
chr6_159458069_159458220	0.15	TAGAP	T-cell activation RhoGTPase activating protein	7906	0.19
chr3_187984346_187984497	0.15	LPP	LIM domain containing preferred translocation partner in lipoma	26769	0.24
chr10_17826229_17826380	0.15	MRC1L1	cDNA FLJ56855, highly similar to Macrophage mannose receptor 1	25058	0.16
chr20_5550410_5550561	0.15	GPCPD1	glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)	5669	0.27
chr10_28822829_28823308	0.15	WAC	WW domain containing adaptor with coiled-coil	16	0.97
chr7_93926282_93926700	0.15	COL1A2	collagen, type I, alpha 2	97382	0.08
chr5_55339622_55339773	0.15	ENSG00000238326	.	43248	0.11
chr5_37370451_37371178	0.15	NUP155	nucleoporin 155kDa	73	0.98
chr7_70773511_70773662	0.15	ENSG00000265878	.	844	0.58
chr5_15575280_15575431	0.15	CTD-2350J17.1		32003	0.21
chr1_205144953_205145111	0.15	DSTYK	dual serine/threonine and tyrosine protein kinase	35662	0.13
chr14_90863482_90863819	0.15	CALM1	calmodulin 1 (phosphorylase kinase, delta)	250	0.92
chr3_31814428_31814579	0.15	OSBPL10-AS1	OSBPL10 antisense RNA 1	56020	0.14
chr2_152146458_152146912	0.15	NMI	N-myc (and STAT) interactor	114	0.97
chrX_80458564_80458878	0.15	SH3BGRL	SH3 domain binding glutamic acid-rich protein like	1279	0.36
chr1_91748546_91748727	0.15	ENSG00000206817	.	21454	0.25
chr12_56435716_56435907	0.15	RPS26	ribosomal protein S26	134	0.6
chr14_23584164_23584381	0.15	CEBPE	CCAAT/enhancer binding protein (C/EBP), epsilon	4553	0.11
chr9_97021933_97022185	0.14	ZNF169	zinc finger protein 169	449	0.8
chr19_10927638_10927909	0.14	ENSG00000207752	.	399	0.76
chr5_66255088_66255484	0.14	MAST4	microtubule associated serine/threonine kinase family member 4	470	0.88
chr1_109935632_109935931	0.14	SORT1	sortilin 1	198	0.93
chr3_119921742_119921893	0.14	ENSG00000206721	.	7350	0.22
chr8_8395574_8395725	0.14	ENSG00000263616	.	44516	0.17
chr9_20144272_20144623	0.14	ENSG00000221744	.	150555	0.04
chr15_69110393_69110544	0.14	ANP32A	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	2757	0.31
chr10_104926250_104926401	0.14	NT5C2	5'-nucleotidase, cytosolic II	8414	0.23
chr7_148843913_148844354	0.14	ZNF398	zinc finger protein 398	427	0.79
chr8_37556330_37556485	0.14	ZNF703	zinc finger protein 703	3138	0.17
chr3_122513057_122513432	0.14	DIRC2	disrupted in renal carcinoma 2	398	0.6
chr6_6592584_6592735	0.14	LY86	lymphocyte antigen 86	3757	0.28
chr6_106583373_106583524	0.14	RP1-134E15.3		35433	0.17
chr9_120466546_120467060	0.14	TLR4	toll-like receptor 4	153	0.96
chr6_113012091_113012242	0.14	ENSG00000252215	.	158782	0.04
chr5_179482246_179482397	0.14	RNF130	ring finger protein 130	16400	0.19
chr1_236767249_236767530	0.14	HEATR1	HEAT repeat containing 1	399	0.87
chr7_19308580_19308778	0.14	FERD3L	Fer3-like bHLH transcription factor	123635	0.05
chr6_151597751_151597996	0.14	ENSG00000252431	.	3874	0.18
chr21_34499350_34499501	0.14	AP000290.7		29513	0.14
chr12_124043713_124043864	0.14	ENSG00000266655	.	22832	0.11
chr5_133583428_133583579	0.14	PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	21670	0.14
chr1_66797787_66798583	0.14	PDE4B	phosphodiesterase 4B, cAMP-specific	313	0.94
chr13_30422824_30423057	0.14	UBL3	ubiquitin-like 3	1881	0.48
chr17_42767403_42767760	0.14	CCDC43	coiled-coil domain containing 43	434	0.75
chr5_98369155_98369504	0.14	ENSG00000200351	.	96878	0.08
chr8_92051814_92052056	0.14	TMEM55A	transmembrane protein 55A	1128	0.39
chr6_79788058_79788292	0.13	PHIP	pleckstrin homology domain interacting protein	222	0.96
chr2_144565732_144565883	0.13	CTD-2252P21.1		32165	0.19
chr11_94226416_94226932	0.13	ANKRD49	ankyrin repeat domain 49	121	0.73
chr22_17651901_17652140	0.13	CECR5	cat eye syndrome chromosome region, candidate 5	5843	0.17
chr1_95700160_95700399	0.13	RWDD3	RWD domain containing 3	512	0.57
chr6_26365718_26366052	0.13	ENSG00000215979	.	105	0.79
chr6_134694363_134694677	0.13	SGK1	serum/glucocorticoid regulated kinase 1	55270	0.15
chr19_13278225_13278635	0.13	CTC-250I14.6		13423	0.11
chr10_105595201_105595352	0.13	SH3PXD2A	SH3 and PX domains 2A	19888	0.19
chr14_59106280_59106431	0.13	DACT1	dishevelled-binding antagonist of beta-catenin 1	800	0.74
chr10_75646822_75647179	0.13	CAMK2G	calcium/calmodulin-dependent protein kinase II gamma	12657	0.12
chr6_26125804_26126001	0.13	HIST1H2AC	histone cluster 1, H2ac	1471	0.17
chr9_23190046_23190197	0.13	ENSG00000265572	.	237019	0.02
chr18_10743903_10744054	0.13	PIEZO2	piezo-type mechanosensitive ion channel component 2	4520	0.28
chr5_173318326_173318892	0.13	CPEB4	cytoplasmic polyadenylation element binding protein 4	929	0.69
chr1_66800579_66801197	0.12	PDE4B	phosphodiesterase 4B, cAMP-specific	3016	0.39
chr10_14049890_14050132	0.12	FRMD4A	FERM domain containing 4A	521	0.82
chr1_2164202_2164388	0.12	SKI	v-ski avian sarcoma viral oncogene homolog	4161	0.15
chr16_48418037_48418576	0.12	SIAH1	siah E3 ubiquitin protein ligase 1	1055	0.5
chr15_67803077_67803228	0.12	C15orf61	chromosome 15 open reading frame 61	10254	0.21
chr11_67142318_67142469	0.12	CLCF1	cardiotrophin-like cytokine factor 1	745	0.41
chr4_22239606_22240002	0.12	ENSG00000238383	.	111269	0.07
chr6_56555605_56555856	0.12	DST	dystonin	47936	0.18
chr1_221219794_221220024	0.12	HLX	H2.0-like homeobox	165325	0.04
chr17_34891354_34891543	0.12	PIGW	phosphatidylinositol glycan anchor biosynthesis, class W	45	0.91
chr1_159852065_159852216	0.12	RP11-190A12.8		15396	0.08
chr1_150979434_150979585	0.12	FAM63A	family with sequence similarity 63, member A	176	0.86
chr17_39471970_39472121	0.12	KRTAP17-1	keratin associated protein 17-1	98	0.92
chrX_39501672_39501823	0.12	ENSG00000263730	.	18723	0.29
chr11_122568313_122568557	0.12	ENSG00000239079	.	28584	0.19
chr6_2222017_2222664	0.12	GMDS	GDP-mannose 4,6-dehydratase	23586	0.28
chr5_123463412_123463801	0.12	CSNK1G3	casein kinase 1, gamma 3	539487	0.0
chr7_92746852_92747341	0.12	SAMD9	sterile alpha motif domain containing 9	179	0.96
chr9_127704164_127704315	0.12	GOLGA1	golgin A1	861	0.6
chr3_15370902_15371053	0.12	SH3BP5	SH3-domain binding protein 5 (BTK-associated)	3090	0.19
chr20_42087283_42087478	0.12	SRSF6	serine/arginine-rich splicing factor 6	812	0.56
chr2_25457035_25457186	0.12	DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	18070	0.19
chr22_18120777_18121028	0.12	BCL2L13	BCL2-like 13 (apoptosis facilitator)	454	0.78
chr17_56709506_56709776	0.12	ENSG00000212195	.	444	0.75
chr8_22525362_22525513	0.12	BIN3	bridging integrator 3	1189	0.35
chr7_72772148_72772660	0.12	ENSG00000206709	.	19201	0.13
chr5_140044777_140044956	0.12	WDR55	WD repeat domain 55	605	0.47
chr16_67222162_67222313	0.12	EXOC3L1	exocyst complex component 3-like 1	1802	0.13
chr6_6943480_6943659	0.12	ENSG00000240936	.	4439	0.33
chr18_56168357_56168508	0.12	RP11-1151B14.4		34215	0.13
chr1_205257217_205257368	0.12	TMCC2	transmembrane and coiled-coil domain family 2	31963	0.12
chr20_56963544_56964018	0.11	VAPB	VAMP (vesicle-associated membrane protein)-associated protein B and C	397	0.89
chr9_99776295_99776451	0.11	HIATL2	hippocampus abundant transcript-like 2	511	0.83
chr12_75875359_75875792	0.11	GLIPR1	GLI pathogenesis-related 1	591	0.74
chr12_53448318_53448482	0.11	RP11-983P16.4		178	0.91
chrY_23354523_23354674	0.11	CYorf17	chromosome Y open reading frame 17	193648	0.03
chr10_120789931_120790695	0.11	NANOS1	nanos homolog 1 (Drosophila)	375	0.81
chr3_11278875_11279026	0.11	HRH1	histamine receptor H1	11233	0.25
chr19_34286123_34286306	0.11	KCTD15	potassium channel tetramerization domain containing 15	624	0.82
chr15_72665455_72665606	0.11	HEXA	hexosaminidase A (alpha polypeptide)	2655	0.21
chr18_72880123_72880274	0.11	ZADH2	zinc binding alcohol dehydrogenase domain containing 2	37270	0.19
chr4_24975617_24975768	0.11	CCDC149	coiled-coil domain containing 149	6078	0.28
chr12_105502043_105502544	0.11	KIAA1033	KIAA1033	801	0.5
chr4_162498417_162498568	0.11	RP11-234O6.2		198387	0.03
chr2_192900733_192900884	0.11	AC098617.1		102	0.98
chr14_89796844_89796995	0.11	RP11-356K23.1		19710	0.18
chrX_3617821_3618286	0.11	PRKX	protein kinase, X-linked	13596	0.21
chr4_15704055_15704284	0.11	BST1	bone marrow stromal cell antigen 1	404	0.85
chr1_72749102_72749377	0.11	NEGR1	neuronal growth regulator 1	822	0.78
chr17_21226277_21226442	0.11	MAP2K3	mitogen-activated protein kinase kinase 3	10905	0.2
chr7_19152184_19152434	0.11	AC003986.6		212	0.92
chr9_130504383_130504534	0.11	TOR2A	torsin family 2, member A	6854	0.1
chr9_118918844_118919316	0.11	PAPPA	pregnancy-associated plasma protein A, pappalysin 1	2997	0.34
chr3_58319217_58319933	0.11	PXK	PX domain containing serine/threonine kinase	542	0.78
chr4_186696107_186696537	0.11	SORBS2	sorbin and SH3 domain containing 2	108	0.98
chr21_26378043_26378194	0.11	ENSG00000232512	.	95327	0.09
chr12_20141265_20141425	0.11	ENSG00000221679	.	15546	0.3
chr13_31481253_31481536	0.11	MEDAG	mesenteric estrogen-dependent adipogenesis	551	0.78
chr10_123469524_123469675	0.11	RP11-78A18.2		26219	0.24

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXC1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0034421	post-translational protein acetylation(GO:0034421)
0.1	0.2	GO:0035455	response to interferon-alpha(GO:0035455)
0.1	0.2	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.1	0.2	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.1	0.2	GO:0051451	myoblast migration(GO:0051451)
0.0	0.1	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.1	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.2	GO:0070245	positive regulation of thymocyte apoptotic process(GO:0070245)
0.0	0.1	GO:0016115	diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0	0.1	GO:0048342	paraxial mesodermal cell differentiation(GO:0048342) paraxial mesodermal cell fate commitment(GO:0048343)
0.0	0.2	GO:0007090	obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.0	0.2	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.1	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.3	GO:0045540	regulation of cholesterol biosynthetic process(GO:0045540)
0.0	0.1	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.1	GO:0006419	alanyl-tRNA aminoacylation(GO:0006419)
0.0	0.1	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.1	GO:0046398	UDP-glucuronate metabolic process(GO:0046398)
0.0	0.1	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.0	0.1	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0	0.1	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.1	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.1	GO:0002634	regulation of germinal center formation(GO:0002634)
0.0	0.1	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0006451	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0	0.1	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0	0.2	GO:0006012	galactose metabolic process(GO:0006012)
0.0	0.1	GO:0051832	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.1	GO:0032780	negative regulation of ATPase activity(GO:0032780)
0.0	0.2	GO:0033523	histone H2B ubiquitination(GO:0033523)
0.0	0.1	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.1	GO:0060632	regulation of microtubule-based movement(GO:0060632)
0.0	0.1	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578) carnitine biosynthetic process(GO:0045329)
0.0	0.1	GO:0009109	coenzyme catabolic process(GO:0009109)
0.0	0.1	GO:0033119	negative regulation of RNA splicing(GO:0033119)
0.0	0.0	GO:0031223	auditory behavior(GO:0031223)
0.0	0.1	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.1	GO:0007144	female meiosis I(GO:0007144)
0.0	0.1	GO:0006828	manganese ion transport(GO:0006828)
0.0	0.2	GO:0014037	Schwann cell differentiation(GO:0014037)
0.0	0.1	GO:0046174	polyol catabolic process(GO:0046174)
0.0	0.3	GO:0048260	positive regulation of receptor-mediated endocytosis(GO:0048260)
0.0	0.0	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.0	GO:0042494	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.1	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0	0.1	GO:0043032	positive regulation of macrophage activation(GO:0043032)
0.0	0.2	GO:0043968	histone H2A acetylation(GO:0043968)
0.0	0.2	GO:0016254	preassembly of GPI anchor in ER membrane(GO:0016254)
0.0	0.1	GO:0042891	tetracycline transport(GO:0015904) antibiotic transport(GO:0042891) toxin transport(GO:1901998)
0.0	0.0	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.1	GO:0044091	membrane biogenesis(GO:0044091)
0.0	0.0	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.1	GO:0045070	positive regulation of viral genome replication(GO:0045070)
0.0	0.0	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0	0.1	GO:0015840	urea transport(GO:0015840)
0.0	0.1	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0	0.0	GO:0033600	negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0	0.0	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.0	GO:0035609	C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0	0.1	GO:0071168	protein localization to chromatin(GO:0071168)
0.0	0.0	GO:0072311	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.0	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0	0.0	GO:0051665	membrane raft localization(GO:0051665)
0.0	0.0	GO:0045002	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0021529	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0	0.1	GO:0032897	negative regulation of viral transcription(GO:0032897)
0.0	0.1	GO:0006553	lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0	0.1	GO:0006385	transcription elongation from RNA polymerase III promoter(GO:0006385) termination of RNA polymerase III transcription(GO:0006386)
0.0	0.0	GO:0090116	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.1	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.0	0.0	GO:0043923	positive regulation by host of viral transcription(GO:0043923)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0016600	flotillin complex(GO:0016600)
0.0	0.1	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.2	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.0	0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.1	GO:0031312	extrinsic component of organelle membrane(GO:0031312)
0.0	0.1	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	0.1	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.0	0.2	GO:0031231	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0	0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.1	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	0.1	GO:0000145	exocyst(GO:0000145)
0.0	0.4	GO:0005626	obsolete insoluble fraction(GO:0005626)
0.0	0.1	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.0	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0001098	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0	0.2	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.2	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.2	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.2	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.1	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.1	GO:0004813	alanine-tRNA ligase activity(GO:0004813)
0.0	0.1	GO:0031177	phosphopantetheine binding(GO:0031177)
0.0	0.1	GO:0002060	purine nucleobase binding(GO:0002060)
0.0	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.1	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.0	0.3	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.1	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.0	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.1	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.1	GO:0046923	ER retention sequence binding(GO:0046923)
0.0	0.1	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0	0.1	GO:0015520	tetracycline:proton antiporter activity(GO:0015520)
0.0	0.1	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0	0.1	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.0	0.0	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.0	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.0	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.0	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.0	GO:0004307	ethanolaminephosphotransferase activity(GO:0004307)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.0	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.1	GO:0009008	DNA-methyltransferase activity(GO:0009008)
0.0	0.1	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.0	0.0	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.0	GO:0008821	crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0	0.0	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.1	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.1	GO:0019864	IgG binding(GO:0019864)
0.0	0.0	GO:0016882	cyclo-ligase activity(GO:0016882)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	0.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	0.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	0.2	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	0.2	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.5	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.1	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.2	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.0	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.2	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.2	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.2	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway