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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for FOXD1_FOXO1_FOXO6_FOXG1_FOXP1

Z-value: 0.48

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Transcription factors associated with FOXD1_FOXO1_FOXO6_FOXG1_FOXP1

Gene Symbol Gene ID Gene Info
FOXD1
ENSG00000251493.2 forkhead box D1
FOXO1
ENSG00000150907.6 forkhead box O1
FOXO6
ENSG00000204060.4 forkhead box O6
FOXG1
ENSG00000176165.7 forkhead box G1
FOXP1
ENSG00000114861.14 forkhead box P1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr5_72739801_72739952FOXD144760.237971-0.862.8e-03Click!
chr5_72746479_72746692FOXD122330.316554-0.826.6e-03Click!
chr5_72741608_72741807FOXD126450.293143-0.771.6e-02Click!
chr5_72733592_72733937FOXD1105880.210827-0.742.3e-02Click!
chr5_72661694_72661845FOXD1825830.086668-0.713.1e-02Click!
chr14_29238229_29238380FOXG120170.253606-0.881.7e-03Click!
chr14_29238530_29238681FOXG123180.227993-0.872.5e-03Click!
chr14_29235333_29235626FOXG14290.694799-0.817.5e-03Click!
chr14_29234676_29234957FOXG12340.601383-0.771.4e-02Click!
chr14_29237083_29237259FOXG18840.510447-0.761.6e-02Click!
chr13_41227499_41227650FOXO1131600.2360410.835.9e-03Click!
chr13_41223921_41224072FOXO1167380.228955-0.752.0e-02Click!
chr13_41237881_41238133FOXO127270.3315560.732.6e-02Click!
chr13_41219212_41219363FOXO1214470.218996-0.703.4e-02Click!
chr13_41238416_41238842FOXO121050.3831560.684.5e-02Click!
chr1_41826426_41827003FOXO68800.6427510.571.1e-01Click!
chr1_41807666_41807817FOXO6198530.204849-0.541.3e-01Click!
chr1_41827168_41827846FOXO6870.9759680.422.6e-01Click!
chr1_41824027_41824178FOXO634920.272371-0.422.6e-01Click!
chr1_41832245_41832396FOXO647260.239646-0.324.1e-01Click!
chr3_71150513_71150664FOXP1291560.254969-0.863.0e-03Click!
chr3_71294181_71294421FOXP1150.986638-0.844.7e-03Click!
chr3_71350015_71350217FOXP137950.2937810.835.4e-03Click!
chr3_71115551_71115702FOXP17080.8127890.809.5e-03Click!
chr3_71157089_71157240FOXP1225800.276377-0.791.1e-02Click!

Activity of the FOXD1_FOXO1_FOXO6_FOXG1_FOXP1 motif across conditions

Conditions sorted by the z-value of the FOXD1_FOXO1_FOXO6_FOXG1_FOXP1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr4_89884993_89885181 0.31 FAM13A
 family with sequence similarity 13, member A
 65964
 0.13
chr7_150264558_150265605 0.28 GIMAP4
 GTPase, IMAP family member 4
 557
 0.78
chr3_151917198_151917573 0.27 MBNL1
 muscleblind-like splicing regulator 1
 68444
 0.12
chr1_198608588_198608957 0.25 PTPRC
 protein tyrosine phosphatase, receptor type, C
 480
 0.86
chr11_3009712_3009890 0.24 NAP1L4
 nucleosome assembly protein 1-like 4
 588
 0.57
chr4_154456967_154457118 0.23 KIAA0922
 KIAA0922
 20006
 0.24
chr6_24951710_24951975 0.20 FAM65B
 family with sequence similarity 65, member B
 15654
 0.22
chr2_158298330_158298802 0.19 ENSG00000216054
 .
 504
 0.79
chr6_24934559_24934719 0.19 FAM65B
 family with sequence similarity 65, member B
 1549
 0.46
chr2_45794731_45794926 0.19 SRBD1
 S1 RNA binding domain 1
 326
 0.88
chr6_11727810_11727987 0.18 ADTRP
 androgen-dependent TFPI-regulating protein
 7991
 0.25
chrX_70329371_70329522 0.18 IL2RG
 interleukin 2 receptor, gamma
 328
 0.79
chr19_17861983_17862176 0.17 FCHO1
 FCH domain only 1
 207
 0.91
chr5_39218193_39218351 0.17 FYB
 FYN binding protein
 1393
 0.56
chr1_84610455_84610717 0.17 PRKACB
 protein kinase, cAMP-dependent, catalytic, beta
 632
 0.82
chr3_16328270_16328443 0.17 OXNAD1
 oxidoreductase NAD-binding domain containing 1
 17608
 0.16
chr22_40323366_40323609 0.17 GRAP2
 GRB2-related adaptor protein 2
 846
 0.6
chr1_209930701_209930998 0.17 TRAF3IP3
 TRAF3 interacting protein 3
 994
 0.46
chr5_39073301_39073622 0.16 RICTOR
 RPTOR independent companion of MTOR, complex 2
 1030
 0.63
chr6_33043813_33044241 0.16 HLA-DPB1
 major histocompatibility complex, class II, DP beta 1
 284
 0.84
chr7_138790255_138790726 0.16 ZC3HAV1
 zinc finger CCCH-type, antiviral 1
 3610
 0.26
chr1_12232983_12233134 0.16 TNFRSF1B
 tumor necrosis factor receptor superfamily, member 1B
 5998
 0.17
chr3_142663096_142663442 0.16 RP11-372E1.4
6187
 0.16
chr7_5436161_5436613 0.16 TNRC18
 trinucleotide repeat containing 18
 8727
 0.16
chr16_30484007_30484505 0.16 ITGAL
 integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
 184
 0.81
chrX_70331541_70331692 0.16 IL2RG
 interleukin 2 receptor, gamma
 135
 0.92
chr15_91137584_91137808 0.15 CRTC3
 CREB regulated transcription coactivator 3
 751
 0.57
chr11_44702468_44702619 0.15 TSPAN18
 tetraspanin 18
 45472
 0.15
chr12_32113291_32114105 0.15 KIAA1551
 KIAA1551
 1345
 0.51
chr5_39201497_39202174 0.15 FYB
 FYN binding protein
 1294
 0.59
chr10_11210404_11210686 0.15 RP3-323N1.2
2794
 0.27
chr8_134071859_134072010 0.15 SLA
 Src-like-adaptor
 669
 0.77
chr1_185663060_185663272 0.15 HMCN1
 hemicentin 1
 40517
 0.17
chr13_41372571_41372761 0.14 SLC25A15
 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
 5372
 0.18
chr17_76776568_76776719 0.14 CYTH1
 cytohesin 1
 1711
 0.35
chr10_22944496_22944670 0.14 PIP4K2A
 phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
 58454
 0.15
chr1_150975096_150975673 0.14 FAM63A
 family with sequence similarity 63, member A
 3577
 0.1
chr15_66083115_66083406 0.14 DENND4A
 DENN/MADD domain containing 4A
 1202
 0.45
chr11_104971052_104971203 0.14 CASP1
 caspase 1, apoptosis-related cysteine peptidase
 1031
 0.28
chr6_152505186_152505339 0.13 SYNE1
 spectrin repeat containing, nuclear envelope 1
 15763
 0.29
chr6_53200265_53200465 0.13 ELOVL5
 ELOVL fatty acid elongase 5
 13222
 0.2
chr21_44104798_44104999 0.13 PDE9A
 phosphodiesterase 9A
 30975
 0.15
chr3_45986008_45986159 0.13 CXCR6
 chemokine (C-X-C motif) receptor 6
 428
 0.8
chr1_198492691_198493057 0.13 ATP6V1G3
 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3
 16930
 0.28
chr6_41906196_41906466 0.13 CCND3
 cyclin D3
 2133
 0.22
chr19_42946806_42946957 0.13 CXCL17
 chemokine (C-X-C motif) ligand 17
 319
 0.82
chr7_852914_853138 0.13 SUN1
 Sad1 and UNC84 domain containing 1
 2502
 0.27
chr19_13906051_13906257 0.13 ZSWIM4
 zinc finger, SWIM-type containing 4
 120
 0.9
chr13_99953472_99953749 0.13 GPR183
 G protein-coupled receptor 183
 6049
 0.22
chr10_71853524_71853675 0.13 AIFM2
 apoptosis-inducing factor, mitochondrion-associated, 2
 30259
 0.15
chr11_96656080_96656231 0.13 ENSG00000200411
 .
 448299
 0.01
chr12_123713862_123714013 0.13 MPHOSPH9
 M-phase phosphoprotein 9
 1056
 0.41
chr5_66646304_66646752 0.13 ENSG00000222939
 .
 113908
 0.07
chr1_161154335_161154531 0.13 B4GALT3
 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
 7146
 0.07
chr2_20776643_20776868 0.13 HS1BP3-IT1
 HS1BP3 intronic transcript 1 (non-protein coding)
 15553
 0.21
chr17_66433856_66434617 0.13 WIPI1
 WD repeat domain, phosphoinositide interacting 1
 4524
 0.23
chr8_125575959_125576110 0.13 MTSS1
 metastasis suppressor 1
 1934
 0.28
chr11_6766181_6766335 0.13 GVINP1
 GTPase, very large interferon inducible pseudogene 1
 23147
 0.11
chr6_25035340_25035594 0.13 ENSG00000244618
 .
 3957
 0.21
chr1_181003153_181003921 0.13 MR1
 major histocompatibility complex, class I-related
 398
 0.84
chr7_134832844_134833492 0.13 AC083862.1
 Uncharacterized protein
 252
 0.58
chr14_71448816_71448967 0.12 PCNX
 pecanex homolog (Drosophila)
 30857
 0.24
chr2_158291882_158292250 0.12 CYTIP
 cytohesin 1 interacting protein
 3860
 0.26
chr14_102861114_102861265 0.12 TECPR2
 tectonin beta-propeller repeat containing 2
 31773
 0.12
chr1_66839032_66839197 0.12 PDE4B
 phosphodiesterase 4B, cAMP-specific
 19049
 0.27
chr10_73847731_73848399 0.12 SPOCK2
 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
 21
 0.98
chr2_218654553_218654808 0.12 DIRC3
 disrupted in renal carcinoma 3
 33402
 0.19
chr1_154926867_154927056 0.12 PBXIP1
 pre-B-cell leukemia homeobox interacting protein 1
 1619
 0.18
chr3_50643497_50643669 0.12 CISH
 cytokine inducible SH2-containing protein
 5620
 0.15
chr3_185826921_185827162 0.12 ETV5
 ets variant 5
 140
 0.97
chr13_99958832_99958994 0.12 GPR183
 G protein-coupled receptor 183
 746
 0.69
chr1_207996298_207996642 0.12 ENSG00000203709
 .
 20602
 0.22
chr2_46578889_46579334 0.12 EPAS1
 endothelial PAS domain protein 1
 54570
 0.13
chr4_56814187_56814608 0.12 CEP135
 centrosomal protein 135kDa
 640
 0.74
chr1_174933757_174934016 0.12 RABGAP1L
 RAB GTPase activating protein 1-like
 19
 0.97
chr14_89895919_89896980 0.12 FOXN3-AS1
 FOXN3 antisense RNA 1
 12751
 0.17
chr3_108205436_108205587 0.12 MYH15
 myosin, heavy chain 15
 42658
 0.16
chr1_6520532_6520815 0.12 TNFRSF25
 tumor necrosis factor receptor superfamily, member 25
 5017
 0.12
chr5_96268734_96268944 0.12 LNPEP
 leucyl/cystinyl aminopeptidase
 2329
 0.27
chr18_60823743_60823894 0.12 RP11-299P2.1
5265
 0.26
chr22_50630477_50630948 0.12 RP3-402G11.25
119
 0.86
chr5_171611170_171611339 0.12 STK10
 serine/threonine kinase 10
 4136
 0.22
chr1_186291918_186292069 0.12 ENSG00000202025
 .
 10933
 0.17
chr16_68033325_68033555 0.12 DPEP2
 dipeptidase 2
 19
 0.94
chr1_111215452_111215765 0.12 KCNA3
 potassium voltage-gated channel, shaker-related subfamily, member 3
 2047
 0.31
chr7_1086655_1086891 0.12 GPR146
 G protein-coupled receptor 146
 2561
 0.15
chr4_164479735_164479886 0.12 ENSG00000264535
 .
 35366
 0.17
chr5_39200681_39200881 0.12 FYB
 FYN binding protein
 2348
 0.41
chr3_151911560_151911983 0.12 MBNL1
 muscleblind-like splicing regulator 1
 74058
 0.11
chrX_19858890_19859041 0.12 SH3KBP1
 SH3-domain kinase binding protein 1
 41096
 0.19
chr16_79123602_79124194 0.12 RP11-556H2.3
49
 0.98
chr7_4784274_4784732 0.12 FOXK1
 forkhead box K1
 4013
 0.21
chr14_53593743_53594005 0.12 DDHD1
 DDHD domain containing 1
 22930
 0.17
chr7_150413706_150414064 0.12 GIMAP1
 GTPase, IMAP family member 1
 240
 0.91
chr1_150847141_150847524 0.12 ARNT
 aryl hydrocarbon receptor nuclear translocator
 1723
 0.26
chr4_40553021_40553619 0.12 RBM47
 RNA binding motif protein 47
 35330
 0.17
chr19_3687681_3687872 0.12 PIP5K1C
 phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
 12612
 0.1
chr10_12390284_12390435 0.11 CAMK1D
 calcium/calmodulin-dependent protein kinase ID
 1122
 0.5
chr1_239881158_239881438 0.11 ENSG00000233355
 .
 1068
 0.49
chr14_98100930_98101414 0.11 ENSG00000240730
 .
 104662
 0.08
chr6_150954132_150954283 0.11 RP11-136K14.2
8394
 0.22
chr14_102289544_102289975 0.11 CTD-2017C7.2
13101
 0.14
chr4_84035760_84036001 0.11 PLAC8
 placenta-specific 8
 9
 0.98
chr6_144665292_144666004 0.11 UTRN
 utrophin
 411
 0.88
chr18_60874185_60874445 0.11 ENSG00000238988
 .
 12417
 0.23
chr2_112177530_112177803 0.11 ENSG00000266139
 .
 98998
 0.09
chr3_187803854_187804005 0.11 LPP
 LIM domain containing preferred translocation partner in lipoma
 67143
 0.12
chr7_26412308_26412459 0.11 AC004540.4
3509
 0.27
chr17_46505734_46505885 0.11 SKAP1
 src kinase associated phosphoprotein 1
 1743
 0.29
chr2_430021_430194 0.11 FAM150B
 family with sequence similarity 150, member B
 141256
 0.04
chr20_52226068_52226301 0.11 ZNF217
 zinc finger protein 217
 753
 0.69
chr17_75103441_75103592 0.11 ENSG00000234912
 .
 18127
 0.18
chr20_55975682_55975833 0.11 RP4-800J21.3
7639
 0.16
chr1_174934321_174935265 0.11 RABGAP1L
 RAB GTPase activating protein 1-like
 888
 0.52
chr1_66806954_66807105 0.11 PDE4B
 phosphodiesterase 4B, cAMP-specific
 9157
 0.31
chr15_34626880_34627184 0.11 SLC12A6
 solute carrier family 12 (potassium/chloride transporter), member 6
 2013
 0.2
chr14_22631434_22631696 0.11 ENSG00000238634
 .
 20678
 0.25
chr1_25656822_25656973 0.11 TMEM50A
 transmembrane protein 50A
 7511
 0.13
chr2_149403004_149403363 0.11 EPC2
 enhancer of polycomb homolog 2 (Drosophila)
 194
 0.97
chr12_113345256_113345451 0.11 OAS1
 2'-5'-oligoadenylate synthetase 1, 40/46kDa
 496
 0.81
chr1_235632222_235632373 0.11 B3GALNT2
 beta-1,3-N-acetylgalactosaminyltransferase 2
 35425
 0.16
chr1_226068766_226068917 0.11 TMEM63A
 transmembrane protein 63A
 1228
 0.35
chr1_226862428_226862635 0.11 ITPKB-IT1
 ITPKB intronic transcript 1 (non-protein coding)
 237
 0.93
chr11_108535331_108535645 0.11 DDX10
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
 264
 0.95
chr9_117690832_117691467 0.11 TNFSF8
 tumor necrosis factor (ligand) superfamily, member 8
 1548
 0.52
chr2_87830138_87830289 0.11 RP11-1399P15.1
52660
 0.16
chr2_198170219_198170545 0.11 ANKRD44-IT1
 ANKRD44 intronic transcript 1 (non-protein coding)
 3139
 0.21
chr7_44665248_44665399 0.11 OGDH
 oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
 1262
 0.46
chr11_102192518_102192994 0.11 BIRC3
 baculoviral IAP repeat containing 3
 3196
 0.22
chr6_159465648_159465970 0.11 TAGAP
 T-cell activation RhoGTPase activating protein
 241
 0.93
chr10_17687713_17687972 0.11 STAM
 signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
 1578
 0.29
chr12_122239467_122240363 0.11 RHOF
 ras homolog family member F (in filopodia)
 919
 0.49
chr6_25138653_25139026 0.11 ENSG00000222373
 .
 53802
 0.11
chr9_88953252_88953465 0.11 ZCCHC6
 zinc finger, CCHC domain containing 6
 4680
 0.26
chr13_74806186_74806399 0.11 ENSG00000206617
 .
 57059
 0.16
chr19_16493261_16493427 0.11 ENSG00000243745
 .
 16426
 0.13
chr1_172149860_172150165 0.11 DNM3OS
 DNM3 opposite strand/antisense RNA
 36078
 0.15
chr2_161995820_161996335 0.10 TANK
 TRAF family member-associated NFKB activator
 2611
 0.33
chr6_10528716_10529334 0.10 GCNT2
 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
 436
 0.83
chr2_220113848_220114166 0.10 STK16
 serine/threonine kinase 16
 3389
 0.09
chr2_68430764_68431023 0.10 RP11-474G23.2
23928
 0.12
chr4_80979447_80979859 0.10 ANTXR2
 anthrax toxin receptor 2
 14064
 0.28
chr5_1800151_1800360 0.10 MRPL36
 mitochondrial ribosomal protein L36
 246
 0.88
chr3_111266223_111266431 0.10 CD96
 CD96 molecule
 5330
 0.28
chr1_160547631_160547822 0.10 CD84
 CD84 molecule
 1537
 0.33
chr17_65241820_65242054 0.10 HELZ
 helicase with zinc finger
 168
 0.89
chr12_6744541_6744794 0.10 LPAR5
 lysophosphatidic acid receptor 5
 946
 0.33
chr9_129286057_129286218 0.10 ENSG00000221768
 .
 7133
 0.22
chr13_50203416_50203569 0.10 ARL11
 ADP-ribosylation factor-like 11
 1057
 0.56
chr1_8455637_8455851 0.10 RERE
 arginine-glutamic acid dipeptide (RE) repeats
 27982
 0.15
chrX_72800965_72801116 0.10 CHIC1
 cysteine-rich hydrophobic domain 1
 17996
 0.28
chr4_16226606_16226757 0.10 TAPT1
 transmembrane anterior posterior transformation 1
 1413
 0.36
chr1_111417492_111418003 0.10 CD53
 CD53 molecule
 1971
 0.34
chr5_134240090_134240263 0.10 PCBD2
 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
 420
 0.81
chr10_17726067_17726351 0.10 ENSG00000251959
 .
 5022
 0.18
chr20_47436634_47436796 0.10 PREX1
 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
 7705
 0.28
chr7_134832355_134832754 0.10 TMEM140
 transmembrane protein 140
 270
 0.58
chr11_75063940_75064091 0.10 ARRB1
 arrestin, beta 1
 1142
 0.41
chr10_21914636_21914787 0.10 MLLT10
 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
 25972
 0.17
chr21_28334749_28335004 0.10 ADAMTS5
 ADAM metallopeptidase with thrombospondin type 1 motif, 5
 3956
 0.26
chrX_24498316_24498580 0.10 PDK3
 pyruvate dehydrogenase kinase, isozyme 3
 14875
 0.2
chr19_6086785_6086936 0.10 CTC-232P5.3
18896
 0.13
chr14_22920576_22920727 0.10 TRDD3
 T cell receptor delta diversity 3
 2546
 0.16
chr15_81594027_81594306 0.10 IL16
 interleukin 16
 2409
 0.29
chr22_24540304_24540599 0.10 CABIN1
 calcineurin binding protein 1
 11355
 0.17
chr19_2428027_2428178 0.10 TIMM13
 translocase of inner mitochondrial membrane 13 homolog (yeast)
 210
 0.91
chr11_45069841_45069992 0.10 PRDM11
 PR domain containing 11
 45648
 0.17
chr7_157145359_157145611 0.10 DNAJB6
 DnaJ (Hsp40) homolog, subfamily B, member 6
 12970
 0.24
chr5_140997567_140997853 0.10 AC008781.7
271
 0.75
chr7_129360327_129360478 0.10 ENSG00000212238
 .
 35704
 0.13
chr15_86233199_86233602 0.10 RP11-815J21.1
10940
 0.11
chr1_70875957_70876778 0.10 CTH
 cystathionase (cystathionine gamma-lyase)
 534
 0.81
chr7_1572516_1572667 0.10 MAFK
 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
 2241
 0.23
chr4_103425480_103425657 0.10 NFKB1
 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
 1036
 0.55
chr11_6767215_6767876 0.10 OR2AG2
 olfactory receptor, family 2, subfamily AG, member 2
 22741
 0.11
chr13_41554167_41554365 0.10 ELF1
 E74-like factor 1 (ets domain transcription factor)
 2152
 0.33
chr1_241715191_241715459 0.10 KMO
 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
 16610
 0.2
chr6_127045549_127045700 0.10 ENSG00000201613
 .
 134085
 0.05
chr8_126442398_126442549 0.10 TRIB1
 tribbles pseudokinase 1
 90
 0.98
chr1_100573281_100573432 0.10 RP4-714D9.2
23329
 0.12
chr3_128838581_128838923 0.10 RAB43
 RAB43, member RAS oncogene family
 1872
 0.23
chrX_3729988_3730150 0.09 RP11-706O15.1
 HCG1981372, isoform CRA_c; Uncharacterized protein
 31829
 0.22
chr12_102222797_102222948 0.09 GNPTAB
 N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
 1585
 0.27
chr2_201987013_201987300 0.09 CFLAR
 CASP8 and FADD-like apoptosis regulator
 44
 0.96
chr19_39894109_39894559 0.09 ZFP36
 ZFP36 ring finger protein
 3119
 0.1
chr13_41554727_41554878 0.09 ELF1
 E74-like factor 1 (ets domain transcription factor)
 1616
 0.4
chr8_10367956_10368344 0.09 PRSS51
 protease, serine, 51
 7375
 0.19
chr21_46337622_46337773 0.09 ITGB2
 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
 3073
 0.14
chr11_119136952_119137103 0.09 ENSG00000222249
 .
 23360
 0.1
chr1_107932269_107932420 0.09 ENSG00000238883
 .
 58833
 0.16
chr11_62476686_62476935 0.09 BSCL2
 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
 18
 0.92
chr9_138967584_138968045 0.09 NACC2
 NACC family member 2, BEN and BTB (POZ) domain containing
 19317
 0.19
chr2_71644611_71645120 0.09 ZNF638
 zinc finger protein 638
 10496
 0.21
chrX_44748789_44748940 0.09 ENSG00000252113
 .
 4113
 0.25
chr15_71740308_71740459 0.09 ENSG00000252813
 .
 27443
 0.23
chr13_41540610_41540946 0.09 ELF1
 E74-like factor 1 (ets domain transcription factor)
 15640
 0.18
chr12_4937651_4937802 0.09 RP3-377H17.2
10395
 0.2
chr12_110517460_110517751 0.09 C12orf76
 chromosome 12 open reading frame 76
 6114
 0.22
chr3_52288072_52288223 0.09 PPM1M
 protein phosphatase, Mg2+/Mn2+ dependent, 1M
 5170
 0.1
chrX_40028928_40029079 0.09 BCOR
 BCL6 corepressor
 7570
 0.32

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXD1_FOXO1_FOXO6_FOXG1_FOXP1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0 0.1 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.1 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.1 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.1 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.1 GO:0042118 endothelial cell activation(GO:0042118)
0.0 0.1 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0 0.1 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.1 GO:0010956 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0 0.1 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.1 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.0 0.0 GO:0050689 negative regulation of defense response to virus by host(GO:0050689)
0.0 0.1 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.1 GO:0051096 positive regulation of helicase activity(GO:0051096)
0.0 0.1 GO:0045630 positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.0 0.1 GO:0051103 DNA ligation involved in DNA repair(GO:0051103)
0.0 0.1 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.1 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.1 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.1 GO:0019348 polyprenol metabolic process(GO:0016093) dolichol metabolic process(GO:0019348)
0.0 0.1 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.1 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.1 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.2 GO:0045070 positive regulation of viral genome replication(GO:0045070)
0.0 0.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.0 GO:0009120 deoxyribonucleoside metabolic process(GO:0009120)
0.0 0.1 GO:0003254 regulation of membrane depolarization(GO:0003254)
0.0 0.1 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.1 GO:0046501 protoporphyrinogen IX metabolic process(GO:0046501)
0.0 0.1 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 0.1 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.1 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.1 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0 0.1 GO:0071354 cellular response to interleukin-6(GO:0071354)
0.0 0.1 GO:0006534 cysteine metabolic process(GO:0006534)
0.0 0.0 GO:2000758 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.0 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.1 GO:0003351 epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.1 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 0.1 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.1 GO:0002283 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 0.0 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.0 0.0 GO:0015959 diadenosine polyphosphate metabolic process(GO:0015959)
0.0 0.0 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0 0.1 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0 0.0 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.1 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0 0.0 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.1 GO:1901797 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0 0.1 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.0 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.1 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.0 0.1 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.0 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.0 GO:0061526 acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056) acetylcholine secretion(GO:0061526)
0.0 0.2 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.1 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.1 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.0 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.0 0.0 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.1 GO:0075713 establishment of viral latency(GO:0019043) establishment of integrated proviral latency(GO:0075713)
0.0 0.0 GO:0030644 cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0 0.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.1 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.1 GO:0051642 centrosome localization(GO:0051642)
0.0 0.0 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.1 GO:0031641 regulation of myelination(GO:0031641)
0.0 0.2 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.2 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.0 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.0 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.0 0.2 GO:0019370 leukotriene biosynthetic process(GO:0019370)
0.0 0.0 GO:0021932 hindbrain radial glia guided cell migration(GO:0021932)
0.0 0.0 GO:0033088 regulation of immature T cell proliferation in thymus(GO:0033084) negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0 0.0 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.1 GO:0050860 negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.1 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.0 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 0.0 GO:0061047 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) positive regulation of branching involved in lung morphogenesis(GO:0061047)
0.0 0.1 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 0.1 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.0 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.0 0.1 GO:0032784 regulation of DNA-templated transcription, elongation(GO:0032784)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.2 GO:0005678 obsolete chromatin assembly complex(GO:0005678)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.1 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0 0.0 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.0 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0017059 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.1 GO:0042555 MCM complex(GO:0042555)
0.0 0.0 GO:0005638 lamin filament(GO:0005638)
0.0 0.2 GO:0001772 immunological synapse(GO:0001772)
0.0 0.0 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.1 GO:0071778 obsolete WINAC complex(GO:0071778)
0.0 0.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0016585 obsolete chromatin remodeling complex(GO:0016585)
0.0 0.1 GO:0032279 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0 0.0 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.1 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.0 GO:0005672 transcription factor TFIIA complex(GO:0005672)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.1 GO:0032142 single guanine insertion binding(GO:0032142) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.1 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.0 0.1 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.2 GO:0005521 lamin binding(GO:0005521)
0.0 0.1 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.1 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.1 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.1 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.1 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.0 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.0 GO:0051734 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.1 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 0.3 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.0 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.0 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.1 GO:0034452 dynactin binding(GO:0034452)
0.0 0.1 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.1 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.1 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.1 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.1 GO:0016520 growth hormone-releasing hormone receptor activity(GO:0016520)
0.0 0.0 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.0 0.0 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.1 GO:0015520 tetracycline:proton antiporter activity(GO:0015520)
0.0 0.0 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.3 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.0 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.0 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0 0.0 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.1 GO:0051400 BH domain binding(GO:0051400)
0.0 0.0 GO:0031708 bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0 0.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.0 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
0.0 0.1 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.0 GO:0017089 glycolipid transporter activity(GO:0017089)
0.0 0.1 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.2 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.0 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.0 0.0 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.0 0.1 GO:0003785 actin monomer binding(GO:0003785)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.0 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.6 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 1.0 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.2 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.0 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.5 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.0 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.4 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.2 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.2 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.1 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events