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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for FOXD1_FOXO1_FOXO6_FOXG1_FOXP1

Z-value: 0.48

Motif logo

Transcription factors associated with FOXD1_FOXO1_FOXO6_FOXG1_FOXP1

Gene Symbol	Gene ID	Gene Info
FOXD1 Ensembl NCBI GeneCards UniProt	ENSG00000251493.2	FOXD1
FOXO1 Ensembl NCBI GeneCards UniProt	ENSG00000150907.6	FOXO1
FOXO6 Ensembl NCBI GeneCards UniProt	ENSG00000204060.4	FOXO6
FOXG1 Ensembl NCBI GeneCards UniProt	ENSG00000176165.7	FOXG1
FOXP1 Ensembl NCBI GeneCards UniProt	ENSG00000114861.14	FOXP1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
FOXD1	chr5_72739801_72739952	4476	0.237971	-0.86	2.8e-03	Click!
FOXD1	chr5_72746479_72746692	2233	0.316554	-0.82	6.6e-03	Click!
FOXD1	chr5_72741608_72741807	2645	0.293143	-0.77	1.6e-02	Click!
FOXD1	chr5_72733592_72733937	10588	0.210827	-0.74	2.3e-02	Click!
FOXD1	chr5_72661694_72661845	82583	0.086668	-0.71	3.1e-02	Click!
FOXG1	chr14_29238229_29238380	2017	0.253606	-0.88	1.7e-03	Click!
FOXG1	chr14_29238530_29238681	2318	0.227993	-0.87	2.5e-03	Click!
FOXG1	chr14_29235333_29235626	429	0.694799	-0.81	7.5e-03	Click!
FOXG1	chr14_29234676_29234957	234	0.601383	-0.77	1.4e-02	Click!
FOXG1	chr14_29237083_29237259	884	0.510447	-0.76	1.6e-02	Click!
FOXO1	chr13_41227499_41227650	13160	0.236041	0.83	5.9e-03	Click!
FOXO1	chr13_41223921_41224072	16738	0.228955	-0.75	2.0e-02	Click!
FOXO1	chr13_41237881_41238133	2727	0.331556	0.73	2.6e-02	Click!
FOXO1	chr13_41219212_41219363	21447	0.218996	-0.70	3.4e-02	Click!
FOXO1	chr13_41238416_41238842	2105	0.383156	0.68	4.5e-02	Click!
FOXO6	chr1_41826426_41827003	880	0.642751	0.57	1.1e-01	Click!
FOXO6	chr1_41807666_41807817	19853	0.204849	-0.54	1.3e-01	Click!
FOXO6	chr1_41827168_41827846	87	0.975968	0.42	2.6e-01	Click!
FOXO6	chr1_41824027_41824178	3492	0.272371	-0.42	2.6e-01	Click!
FOXO6	chr1_41832245_41832396	4726	0.239646	-0.32	4.1e-01	Click!
FOXP1	chr3_71150513_71150664	29156	0.254969	-0.86	3.0e-03	Click!
FOXP1	chr3_71294181_71294421	15	0.986638	-0.84	4.7e-03	Click!
FOXP1	chr3_71350015_71350217	3795	0.293781	0.83	5.4e-03	Click!
FOXP1	chr3_71115551_71115702	708	0.812789	0.80	9.5e-03	Click!
FOXP1	chr3_71157089_71157240	22580	0.276377	-0.79	1.1e-02	Click!

Activity of the FOXD1_FOXO1_FOXO6_FOXG1_FOXP1 motif across conditions

Conditions sorted by the z-value of the FOXD1_FOXO1_FOXO6_FOXG1_FOXP1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr4_89884993_89885181	0.31	FAM13A	family with sequence similarity 13, member A	65964	0.13
chr7_150264558_150265605	0.28	GIMAP4	GTPase, IMAP family member 4	557	0.78
chr3_151917198_151917573	0.27	MBNL1	muscleblind-like splicing regulator 1	68444	0.12
chr1_198608588_198608957	0.25	PTPRC	protein tyrosine phosphatase, receptor type, C	480	0.86
chr11_3009712_3009890	0.24	NAP1L4	nucleosome assembly protein 1-like 4	588	0.57
chr4_154456967_154457118	0.23	KIAA0922	KIAA0922	20006	0.24
chr6_24951710_24951975	0.20	FAM65B	family with sequence similarity 65, member B	15654	0.22
chr2_158298330_158298802	0.19	ENSG00000216054	.	504	0.79
chr6_24934559_24934719	0.19	FAM65B	family with sequence similarity 65, member B	1549	0.46
chr2_45794731_45794926	0.19	SRBD1	S1 RNA binding domain 1	326	0.88
chr6_11727810_11727987	0.18	ADTRP	androgen-dependent TFPI-regulating protein	7991	0.25
chrX_70329371_70329522	0.18	IL2RG	interleukin 2 receptor, gamma	328	0.79
chr19_17861983_17862176	0.17	FCHO1	FCH domain only 1	207	0.91
chr5_39218193_39218351	0.17	FYB	FYN binding protein	1393	0.56
chr1_84610455_84610717	0.17	PRKACB	protein kinase, cAMP-dependent, catalytic, beta	632	0.82
chr3_16328270_16328443	0.17	OXNAD1	oxidoreductase NAD-binding domain containing 1	17608	0.16
chr22_40323366_40323609	0.17	GRAP2	GRB2-related adaptor protein 2	846	0.6
chr1_209930701_209930998	0.17	TRAF3IP3	TRAF3 interacting protein 3	994	0.46
chr5_39073301_39073622	0.16	RICTOR	RPTOR independent companion of MTOR, complex 2	1030	0.63
chr6_33043813_33044241	0.16	HLA-DPB1	major histocompatibility complex, class II, DP beta 1	284	0.84
chr7_138790255_138790726	0.16	ZC3HAV1	zinc finger CCCH-type, antiviral 1	3610	0.26
chr1_12232983_12233134	0.16	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	5998	0.17
chr3_142663096_142663442	0.16	RP11-372E1.4		6187	0.16
chr7_5436161_5436613	0.16	TNRC18	trinucleotide repeat containing 18	8727	0.16
chr16_30484007_30484505	0.16	ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	184	0.81
chrX_70331541_70331692	0.16	IL2RG	interleukin 2 receptor, gamma	135	0.92
chr15_91137584_91137808	0.15	CRTC3	CREB regulated transcription coactivator 3	751	0.57
chr11_44702468_44702619	0.15	TSPAN18	tetraspanin 18	45472	0.15
chr12_32113291_32114105	0.15	KIAA1551	KIAA1551	1345	0.51
chr5_39201497_39202174	0.15	FYB	FYN binding protein	1294	0.59
chr10_11210404_11210686	0.15	RP3-323N1.2		2794	0.27
chr8_134071859_134072010	0.15	SLA	Src-like-adaptor	669	0.77
chr1_185663060_185663272	0.15	HMCN1	hemicentin 1	40517	0.17
chr13_41372571_41372761	0.14	SLC25A15	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15	5372	0.18
chr17_76776568_76776719	0.14	CYTH1	cytohesin 1	1711	0.35
chr10_22944496_22944670	0.14	PIP4K2A	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	58454	0.15
chr1_150975096_150975673	0.14	FAM63A	family with sequence similarity 63, member A	3577	0.1
chr15_66083115_66083406	0.14	DENND4A	DENN/MADD domain containing 4A	1202	0.45
chr11_104971052_104971203	0.14	CASP1	caspase 1, apoptosis-related cysteine peptidase	1031	0.28
chr6_152505186_152505339	0.13	SYNE1	spectrin repeat containing, nuclear envelope 1	15763	0.29
chr6_53200265_53200465	0.13	ELOVL5	ELOVL fatty acid elongase 5	13222	0.2
chr21_44104798_44104999	0.13	PDE9A	phosphodiesterase 9A	30975	0.15
chr3_45986008_45986159	0.13	CXCR6	chemokine (C-X-C motif) receptor 6	428	0.8
chr1_198492691_198493057	0.13	ATP6V1G3	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3	16930	0.28
chr6_41906196_41906466	0.13	CCND3	cyclin D3	2133	0.22
chr19_42946806_42946957	0.13	CXCL17	chemokine (C-X-C motif) ligand 17	319	0.82
chr7_852914_853138	0.13	SUN1	Sad1 and UNC84 domain containing 1	2502	0.27
chr19_13906051_13906257	0.13	ZSWIM4	zinc finger, SWIM-type containing 4	120	0.9
chr13_99953472_99953749	0.13	GPR183	G protein-coupled receptor 183	6049	0.22
chr10_71853524_71853675	0.13	AIFM2	apoptosis-inducing factor, mitochondrion-associated, 2	30259	0.15
chr11_96656080_96656231	0.13	ENSG00000200411	.	448299	0.01
chr12_123713862_123714013	0.13	MPHOSPH9	M-phase phosphoprotein 9	1056	0.41
chr5_66646304_66646752	0.13	ENSG00000222939	.	113908	0.07
chr1_161154335_161154531	0.13	B4GALT3	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3	7146	0.07
chr2_20776643_20776868	0.13	HS1BP3-IT1	HS1BP3 intronic transcript 1 (non-protein coding)	15553	0.21
chr17_66433856_66434617	0.13	WIPI1	WD repeat domain, phosphoinositide interacting 1	4524	0.23
chr8_125575959_125576110	0.13	MTSS1	metastasis suppressor 1	1934	0.28
chr11_6766181_6766335	0.13	GVINP1	GTPase, very large interferon inducible pseudogene 1	23147	0.11
chr6_25035340_25035594	0.13	ENSG00000244618	.	3957	0.21
chr1_181003153_181003921	0.13	MR1	major histocompatibility complex, class I-related	398	0.84
chr7_134832844_134833492	0.13	AC083862.1	Uncharacterized protein	252	0.58
chr14_71448816_71448967	0.12	PCNX	pecanex homolog (Drosophila)	30857	0.24
chr2_158291882_158292250	0.12	CYTIP	cytohesin 1 interacting protein	3860	0.26
chr14_102861114_102861265	0.12	TECPR2	tectonin beta-propeller repeat containing 2	31773	0.12
chr1_66839032_66839197	0.12	PDE4B	phosphodiesterase 4B, cAMP-specific	19049	0.27
chr10_73847731_73848399	0.12	SPOCK2	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	21	0.98
chr2_218654553_218654808	0.12	DIRC3	disrupted in renal carcinoma 3	33402	0.19
chr1_154926867_154927056	0.12	PBXIP1	pre-B-cell leukemia homeobox interacting protein 1	1619	0.18
chr3_50643497_50643669	0.12	CISH	cytokine inducible SH2-containing protein	5620	0.15
chr3_185826921_185827162	0.12	ETV5	ets variant 5	140	0.97
chr13_99958832_99958994	0.12	GPR183	G protein-coupled receptor 183	746	0.69
chr1_207996298_207996642	0.12	ENSG00000203709	.	20602	0.22
chr2_46578889_46579334	0.12	EPAS1	endothelial PAS domain protein 1	54570	0.13
chr4_56814187_56814608	0.12	CEP135	centrosomal protein 135kDa	640	0.74
chr1_174933757_174934016	0.12	RABGAP1L	RAB GTPase activating protein 1-like	19	0.97
chr14_89895919_89896980	0.12	FOXN3-AS1	FOXN3 antisense RNA 1	12751	0.17
chr3_108205436_108205587	0.12	MYH15	myosin, heavy chain 15	42658	0.16
chr1_6520532_6520815	0.12	TNFRSF25	tumor necrosis factor receptor superfamily, member 25	5017	0.12
chr5_96268734_96268944	0.12	LNPEP	leucyl/cystinyl aminopeptidase	2329	0.27
chr18_60823743_60823894	0.12	RP11-299P2.1		5265	0.26
chr22_50630477_50630948	0.12	RP3-402G11.25		119	0.86
chr5_171611170_171611339	0.12	STK10	serine/threonine kinase 10	4136	0.22
chr1_186291918_186292069	0.12	ENSG00000202025	.	10933	0.17
chr16_68033325_68033555	0.12	DPEP2	dipeptidase 2	19	0.94
chr1_111215452_111215765	0.12	KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	2047	0.31
chr7_1086655_1086891	0.12	GPR146	G protein-coupled receptor 146	2561	0.15
chr4_164479735_164479886	0.12	ENSG00000264535	.	35366	0.17
chr5_39200681_39200881	0.12	FYB	FYN binding protein	2348	0.41
chr3_151911560_151911983	0.12	MBNL1	muscleblind-like splicing regulator 1	74058	0.11
chrX_19858890_19859041	0.12	SH3KBP1	SH3-domain kinase binding protein 1	41096	0.19
chr16_79123602_79124194	0.12	RP11-556H2.3		49	0.98
chr7_4784274_4784732	0.12	FOXK1	forkhead box K1	4013	0.21
chr14_53593743_53594005	0.12	DDHD1	DDHD domain containing 1	22930	0.17
chr7_150413706_150414064	0.12	GIMAP1	GTPase, IMAP family member 1	240	0.91
chr1_150847141_150847524	0.12	ARNT	aryl hydrocarbon receptor nuclear translocator	1723	0.26
chr4_40553021_40553619	0.12	RBM47	RNA binding motif protein 47	35330	0.17
chr19_3687681_3687872	0.12	PIP5K1C	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	12612	0.1
chr10_12390284_12390435	0.11	CAMK1D	calcium/calmodulin-dependent protein kinase ID	1122	0.5
chr1_239881158_239881438	0.11	ENSG00000233355	.	1068	0.49
chr14_98100930_98101414	0.11	ENSG00000240730	.	104662	0.08
chr6_150954132_150954283	0.11	RP11-136K14.2		8394	0.22
chr14_102289544_102289975	0.11	CTD-2017C7.2		13101	0.14
chr4_84035760_84036001	0.11	PLAC8	placenta-specific 8	9	0.98
chr6_144665292_144666004	0.11	UTRN	utrophin	411	0.88
chr18_60874185_60874445	0.11	ENSG00000238988	.	12417	0.23
chr2_112177530_112177803	0.11	ENSG00000266139	.	98998	0.09
chr3_187803854_187804005	0.11	LPP	LIM domain containing preferred translocation partner in lipoma	67143	0.12
chr7_26412308_26412459	0.11	AC004540.4		3509	0.27
chr17_46505734_46505885	0.11	SKAP1	src kinase associated phosphoprotein 1	1743	0.29
chr2_430021_430194	0.11	FAM150B	family with sequence similarity 150, member B	141256	0.04
chr20_52226068_52226301	0.11	ZNF217	zinc finger protein 217	753	0.69
chr17_75103441_75103592	0.11	ENSG00000234912	.	18127	0.18
chr20_55975682_55975833	0.11	RP4-800J21.3		7639	0.16
chr1_174934321_174935265	0.11	RABGAP1L	RAB GTPase activating protein 1-like	888	0.52
chr1_66806954_66807105	0.11	PDE4B	phosphodiesterase 4B, cAMP-specific	9157	0.31
chr15_34626880_34627184	0.11	SLC12A6	solute carrier family 12 (potassium/chloride transporter), member 6	2013	0.2
chr14_22631434_22631696	0.11	ENSG00000238634	.	20678	0.25
chr1_25656822_25656973	0.11	TMEM50A	transmembrane protein 50A	7511	0.13
chr2_149403004_149403363	0.11	EPC2	enhancer of polycomb homolog 2 (Drosophila)	194	0.97
chr12_113345256_113345451	0.11	OAS1	2'-5'-oligoadenylate synthetase 1, 40/46kDa	496	0.81
chr1_235632222_235632373	0.11	B3GALNT2	beta-1,3-N-acetylgalactosaminyltransferase 2	35425	0.16
chr1_226068766_226068917	0.11	TMEM63A	transmembrane protein 63A	1228	0.35
chr1_226862428_226862635	0.11	ITPKB-IT1	ITPKB intronic transcript 1 (non-protein coding)	237	0.93
chr11_108535331_108535645	0.11	DDX10	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	264	0.95
chr9_117690832_117691467	0.11	TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	1548	0.52
chr2_87830138_87830289	0.11	RP11-1399P15.1		52660	0.16
chr2_198170219_198170545	0.11	ANKRD44-IT1	ANKRD44 intronic transcript 1 (non-protein coding)	3139	0.21
chr7_44665248_44665399	0.11	OGDH	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	1262	0.46
chr11_102192518_102192994	0.11	BIRC3	baculoviral IAP repeat containing 3	3196	0.22
chr6_159465648_159465970	0.11	TAGAP	T-cell activation RhoGTPase activating protein	241	0.93
chr10_17687713_17687972	0.11	STAM	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	1578	0.29
chr12_122239467_122240363	0.11	RHOF	ras homolog family member F (in filopodia)	919	0.49
chr6_25138653_25139026	0.11	ENSG00000222373	.	53802	0.11
chr9_88953252_88953465	0.11	ZCCHC6	zinc finger, CCHC domain containing 6	4680	0.26
chr13_74806186_74806399	0.11	ENSG00000206617	.	57059	0.16
chr19_16493261_16493427	0.11	ENSG00000243745	.	16426	0.13
chr1_172149860_172150165	0.11	DNM3OS	DNM3 opposite strand/antisense RNA	36078	0.15
chr2_161995820_161996335	0.10	TANK	TRAF family member-associated NFKB activator	2611	0.33
chr6_10528716_10529334	0.10	GCNT2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	436	0.83
chr2_220113848_220114166	0.10	STK16	serine/threonine kinase 16	3389	0.09
chr2_68430764_68431023	0.10	RP11-474G23.2		23928	0.12
chr4_80979447_80979859	0.10	ANTXR2	anthrax toxin receptor 2	14064	0.28
chr5_1800151_1800360	0.10	MRPL36	mitochondrial ribosomal protein L36	246	0.88
chr3_111266223_111266431	0.10	CD96	CD96 molecule	5330	0.28
chr1_160547631_160547822	0.10	CD84	CD84 molecule	1537	0.33
chr17_65241820_65242054	0.10	HELZ	helicase with zinc finger	168	0.89
chr12_6744541_6744794	0.10	LPAR5	lysophosphatidic acid receptor 5	946	0.33
chr9_129286057_129286218	0.10	ENSG00000221768	.	7133	0.22
chr13_50203416_50203569	0.10	ARL11	ADP-ribosylation factor-like 11	1057	0.56
chr1_8455637_8455851	0.10	RERE	arginine-glutamic acid dipeptide (RE) repeats	27982	0.15
chrX_72800965_72801116	0.10	CHIC1	cysteine-rich hydrophobic domain 1	17996	0.28
chr4_16226606_16226757	0.10	TAPT1	transmembrane anterior posterior transformation 1	1413	0.36
chr1_111417492_111418003	0.10	CD53	CD53 molecule	1971	0.34
chr5_134240090_134240263	0.10	PCBD2	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2	420	0.81
chr10_17726067_17726351	0.10	ENSG00000251959	.	5022	0.18
chr20_47436634_47436796	0.10	PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	7705	0.28
chr7_134832355_134832754	0.10	TMEM140	transmembrane protein 140	270	0.58
chr11_75063940_75064091	0.10	ARRB1	arrestin, beta 1	1142	0.41
chr10_21914636_21914787	0.10	MLLT10	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10	25972	0.17
chr21_28334749_28335004	0.10	ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif, 5	3956	0.26
chrX_24498316_24498580	0.10	PDK3	pyruvate dehydrogenase kinase, isozyme 3	14875	0.2
chr19_6086785_6086936	0.10	CTC-232P5.3		18896	0.13
chr14_22920576_22920727	0.10	TRDD3	T cell receptor delta diversity 3	2546	0.16
chr15_81594027_81594306	0.10	IL16	interleukin 16	2409	0.29
chr22_24540304_24540599	0.10	CABIN1	calcineurin binding protein 1	11355	0.17
chr19_2428027_2428178	0.10	TIMM13	translocase of inner mitochondrial membrane 13 homolog (yeast)	210	0.91
chr11_45069841_45069992	0.10	PRDM11	PR domain containing 11	45648	0.17
chr7_157145359_157145611	0.10	DNAJB6	DnaJ (Hsp40) homolog, subfamily B, member 6	12970	0.24
chr5_140997567_140997853	0.10	AC008781.7		271	0.75
chr7_129360327_129360478	0.10	ENSG00000212238	.	35704	0.13
chr15_86233199_86233602	0.10	RP11-815J21.1		10940	0.11
chr1_70875957_70876778	0.10	CTH	cystathionase (cystathionine gamma-lyase)	534	0.81
chr7_1572516_1572667	0.10	MAFK	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K	2241	0.23
chr4_103425480_103425657	0.10	NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	1036	0.55
chr11_6767215_6767876	0.10	OR2AG2	olfactory receptor, family 2, subfamily AG, member 2	22741	0.11
chr13_41554167_41554365	0.10	ELF1	E74-like factor 1 (ets domain transcription factor)	2152	0.33
chr1_241715191_241715459	0.10	KMO	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	16610	0.2
chr6_127045549_127045700	0.10	ENSG00000201613	.	134085	0.05
chr8_126442398_126442549	0.10	TRIB1	tribbles pseudokinase 1	90	0.98
chr1_100573281_100573432	0.10	RP4-714D9.2		23329	0.12
chr3_128838581_128838923	0.10	RAB43	RAB43, member RAS oncogene family	1872	0.23
chrX_3729988_3730150	0.09	RP11-706O15.1	HCG1981372, isoform CRA_c; Uncharacterized protein	31829	0.22
chr12_102222797_102222948	0.09	GNPTAB	N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits	1585	0.27
chr2_201987013_201987300	0.09	CFLAR	CASP8 and FADD-like apoptosis regulator	44	0.96
chr19_39894109_39894559	0.09	ZFP36	ZFP36 ring finger protein	3119	0.1
chr13_41554727_41554878	0.09	ELF1	E74-like factor 1 (ets domain transcription factor)	1616	0.4
chr8_10367956_10368344	0.09	PRSS51	protease, serine, 51	7375	0.19
chr21_46337622_46337773	0.09	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	3073	0.14
chr11_119136952_119137103	0.09	ENSG00000222249	.	23360	0.1
chr1_107932269_107932420	0.09	ENSG00000238883	.	58833	0.16
chr11_62476686_62476935	0.09	BSCL2	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	18	0.92
chr9_138967584_138968045	0.09	NACC2	NACC family member 2, BEN and BTB (POZ) domain containing	19317	0.19
chr2_71644611_71645120	0.09	ZNF638	zinc finger protein 638	10496	0.21
chrX_44748789_44748940	0.09	ENSG00000252113	.	4113	0.25
chr15_71740308_71740459	0.09	ENSG00000252813	.	27443	0.23
chr13_41540610_41540946	0.09	ELF1	E74-like factor 1 (ets domain transcription factor)	15640	0.18
chr12_4937651_4937802	0.09	RP3-377H17.2		10395	0.2
chr12_110517460_110517751	0.09	C12orf76	chromosome 12 open reading frame 76	6114	0.22
chr3_52288072_52288223	0.09	PPM1M	protein phosphatase, Mg2+/Mn2+ dependent, 1M	5170	0.1
chrX_40028928_40029079	0.09	BCOR	BCL6 corepressor	7570	0.32

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXD1_FOXO1_FOXO6_FOXG1_FOXP1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.1	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.1	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0046548	retinal rod cell development(GO:0046548)
0.0	0.1	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.1	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0	0.1	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.1	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.1	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.0	0.1	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.0	GO:0050689	negative regulation of defense response to virus by host(GO:0050689)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0051096	positive regulation of helicase activity(GO:0051096)
0.0	0.1	GO:0045630	positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.0	0.1	GO:0051103	DNA ligation involved in DNA repair(GO:0051103)
0.0	0.1	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.1	GO:0032780	negative regulation of ATPase activity(GO:0032780)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.1	GO:0019348	polyprenol metabolic process(GO:0016093) dolichol metabolic process(GO:0019348)
0.0	0.1	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.0	0.1	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.1	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.2	GO:0045070	positive regulation of viral genome replication(GO:0045070)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.0	GO:0009120	deoxyribonucleoside metabolic process(GO:0009120)
0.0	0.1	GO:0003254	regulation of membrane depolarization(GO:0003254)
0.0	0.1	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.1	GO:0045541	negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0	0.1	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.1	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0	0.1	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0	0.1	GO:0071354	cellular response to interleukin-6(GO:0071354)
0.0	0.1	GO:0006534	cysteine metabolic process(GO:0006534)
0.0	0.0	GO:2000758	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.0	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.1	GO:0003351	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.1	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0	0.1	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0002283	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.0	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.0	GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0	0.1	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.0	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0	0.1	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0	0.0	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.1	GO:1901797	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.1	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.0	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:0033119	negative regulation of RNA splicing(GO:0033119)
0.0	0.1	GO:0045793	positive regulation of cell size(GO:0045793)
0.0	0.0	GO:0032237	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.0	GO:0061526	acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056) acetylcholine secretion(GO:0061526)
0.0	0.2	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.1	GO:0006303	double-strand break repair via nonhomologous end joining(GO:0006303)
0.0	0.1	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
0.0	0.0	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.0	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.1	GO:0075713	establishment of viral latency(GO:0019043) establishment of integrated proviral latency(GO:0075713)
0.0	0.0	GO:0030644	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.1	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.1	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.1	GO:0051642	centrosome localization(GO:0051642)
0.0	0.0	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.1	GO:0031641	regulation of myelination(GO:0031641)
0.0	0.2	GO:0051568	histone H3-K4 methylation(GO:0051568)
0.0	0.2	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.0	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.0	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.2	GO:0019370	leukotriene biosynthetic process(GO:0019370)
0.0	0.0	GO:0021932	hindbrain radial glia guided cell migration(GO:0021932)
0.0	0.0	GO:0033088	regulation of immature T cell proliferation in thymus(GO:0033084) negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0	0.0	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.1	GO:0050860	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.1	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.0	GO:0009313	oligosaccharide catabolic process(GO:0009313)
0.0	0.0	GO:0061047	foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) positive regulation of branching involved in lung morphogenesis(GO:0061047)
0.0	0.1	GO:0000380	alternative mRNA splicing, via spliceosome(GO:0000380)
0.0	0.1	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.0	GO:0006434	seryl-tRNA aminoacylation(GO:0006434)
0.0	0.1	GO:0032784	regulation of DNA-templated transcription, elongation(GO:0032784)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.1	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	GO:0031932	TORC2 complex(GO:0031932)
0.2	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.1	GO:0072487	MSL complex(GO:0072487)
0.1	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	GO:0017059	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.1	GO:0042555	MCM complex(GO:0042555)
0.0	GO:0005638	lamin filament(GO:0005638)
0.2	GO:0001772	immunological synapse(GO:0001772)
0.0	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.1	GO:0071778	obsolete WINAC complex(GO:0071778)
0.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.1	GO:0016585	obsolete chromatin remodeling complex(GO:0016585)
0.1	GO:0032279	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.1	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	GO:0005672	transcription factor TFIIA complex(GO:0005672)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.1	GO:0032142	single guanine insertion binding(GO:0032142) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0055103	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.2	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.1	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.1	GO:0016454	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0	0.0	GO:0031628	opioid receptor binding(GO:0031628)
0.0	0.0	GO:0051734	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.3	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.0	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.0	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0034452	dynactin binding(GO:0034452)
0.0	0.1	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.1	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.1	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.0	0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.0	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894)
0.0	0.0	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.1	GO:0015520	tetracycline:proton antiporter activity(GO:0015520)
0.0	0.0	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.3	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.0	GO:0004875	complement receptor activity(GO:0004875)
0.0	0.0	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.0	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.1	GO:0051400	BH domain binding(GO:0051400)
0.0	0.0	GO:0031708	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.6	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.0	GO:0004307	ethanolaminephosphotransferase activity(GO:0004307)
0.0	0.1	GO:0004931	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0	0.0	GO:0017089	glycolipid transporter activity(GO:0017089)
0.0	0.1	GO:0016805	dipeptidase activity(GO:0016805)
0.0	0.1	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0	0.2	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.0	GO:0004828	serine-tRNA ligase activity(GO:0004828)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.1	GO:0003785	actin monomer binding(GO:0003785)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.2	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.6	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
1.0	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.2	PID IL3 PATHWAY	IL3-mediated signaling events
0.0	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.0	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.5	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.4	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.3	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.2	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.2	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.2	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.1	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.2	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events