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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for FOXD3_FOXI1_FOXF1

Z-value: 1.46

Motif logo

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Transcription factors associated with FOXD3_FOXI1_FOXF1

Gene Symbol Gene ID Gene Info
ENSG00000187140.4 FOXD3
ENSG00000168269.7 FOXI1
ENSG00000103241.5 FOXF1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
FOXD3chr1_63788500_63788912240.911565-0.049.2e-01Click!
FOXF1chr16_86549558_8654970955000.2148770.771.5e-02Click!
FOXF1chr16_86430072_864302231139860.0590820.722.8e-02Click!
FOXF1chr16_86491585_86491816524330.1422380.655.8e-02Click!
FOXF1chr16_86548952_8654910348940.2219580.646.1e-02Click!
FOXF1chr16_86430424_864305991136220.0593710.551.2e-01Click!
FOXI1chr5_169548179_169548330153370.2476500.656.1e-02Click!
FOXI1chr5_169527303_16952745455230.2816510.551.2e-01Click!
FOXI1chr5_169577979_169578130451370.1599760.422.7e-01Click!
FOXI1chr5_169524818_16952496980080.264348-0.363.5e-01Click!
FOXI1chr5_169540388_16954053975460.270713-0.127.5e-01Click!

Activity of the FOXD3_FOXI1_FOXF1 motif across conditions

Conditions sorted by the z-value of the FOXD3_FOXI1_FOXF1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr12_116872831_116873001 0.93 ENSG00000264037
.
6793
0.3
chr17_60868253_60868692 0.86 MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
15529
0.23
chr13_33858654_33859881 0.86 STARD13
StAR-related lipid transfer (START) domain containing 13
625
0.76
chr15_96883311_96883827 0.86 ENSG00000222651
.
7079
0.16
chr7_121513447_121513715 0.82 PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
166
0.97
chr6_86114788_86115158 0.77 NT5E
5'-nucleotidase, ecto (CD73)
44836
0.19
chr3_55520023_55520469 0.74 WNT5A
wingless-type MMTV integration site family, member 5A
1085
0.48
chr9_684288_685148 0.74 RP11-130C19.3

837
0.67
chr16_86603613_86603777 0.74 RP11-463O9.5

2328
0.23
chr4_169553568_169553728 0.73 PALLD
palladin, cytoskeletal associated protein
880
0.63
chr17_4690588_4690857 0.70 VMO1
vitelline membrane outer layer 1 homolog (chicken)
994
0.28
chr15_96874865_96875199 0.69 NR2F2
nuclear receptor subfamily 2, group F, member 2
734
0.54
chr8_15398472_15398721 0.69 TUSC3
tumor suppressor candidate 3
804
0.72
chr4_166793911_166794064 0.67 TLL1
tolloid-like 1
423
0.91
chr7_6521360_6521521 0.67 FLJ20306
CDNA FLJ20306 fis, clone HEP06881; Putative uncharacterized protein FLJ20306; Uncharacterized protein
1482
0.28
chr3_149094469_149095370 0.66 TM4SF1-AS1
TM4SF1 antisense RNA 1
646
0.47
chr2_65593026_65593803 0.65 SPRED2
sprouty-related, EVH1 domain containing 2
370
0.89
chr2_201473941_201474433 0.64 AOX1
aldehyde oxidase 1
21290
0.2
chr9_117879769_117880175 0.62 TNC
tenascin C
506
0.85
chr3_112351475_112351838 0.62 CCDC80
coiled-coil domain containing 80
5288
0.27
chr3_65941462_65941807 0.62 MAGI1-IT1
MAGI1 intronic transcript 1 (non-protein coding)
1401
0.43
chr9_89049166_89049463 0.61 ENSG00000222293
.
11271
0.28
chr7_134464463_134465343 0.60 CALD1
caldesmon 1
474
0.89
chr3_192288894_192289136 0.60 ENSG00000238902
.
37114
0.17
chr3_64252728_64253099 0.59 PRICKLE2
prickle homolog 2 (Drosophila)
742
0.75
chr14_52707563_52708006 0.59 PTGDR
prostaglandin D2 receptor (DP)
26647
0.22
chr8_13132829_13133895 0.59 DLC1
deleted in liver cancer 1
693
0.78
chr11_88288591_88288966 0.59 GRM5-AS1
GRM5 antisense RNA 1
43862
0.18
chr3_112358958_112359194 0.58 CCDC80
coiled-coil domain containing 80
1040
0.62
chr11_89027115_89027763 0.58 TYR
tyrosinase
116819
0.06
chr3_87039220_87039752 0.57 VGLL3
vestigial like 3 (Drosophila)
366
0.93
chr6_119468029_119468476 0.57 FAM184A
family with sequence similarity 184, member A
2100
0.42
chr6_150176715_150177267 0.56 RP11-350J20.12

3393
0.15
chr7_90892646_90892855 0.54 FZD1
frizzled family receptor 1
1033
0.71
chr22_46479348_46479691 0.54 FLJ27365
hsa-mir-4763
2364
0.16
chr2_12959508_12959845 0.54 ENSG00000264370
.
82183
0.11
chr3_120168709_120169860 0.54 FSTL1
follistatin-like 1
554
0.84
chr5_16934966_16935117 0.54 MYO10
myosin X
1006
0.59
chr17_64464860_64465690 0.53 RP11-4F22.2

52303
0.15
chr3_116582620_116583104 0.53 ENSG00000265433
.
13648
0.25
chr10_97049818_97050125 0.53 PDLIM1
PDZ and LIM domain 1
810
0.7
chr19_34359259_34359976 0.53 ENSG00000240626
.
58913
0.13
chr10_88519051_88519241 0.53 BMPR1A
bone morphogenetic protein receptor, type IA
2739
0.22
chr9_22007341_22007594 0.52 CDKN2B
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
1485
0.34
chr3_167811230_167811432 0.52 GOLIM4
golgi integral membrane protein 4
1801
0.51
chr3_149938739_149938966 0.52 RP11-167H9.4

123033
0.05
chr3_147111691_147112234 0.51 ZIC1
Zic family member 1
280
0.9
chr4_115282272_115282768 0.51 UGT8
UDP glycosyltransferase 8
237091
0.02
chr1_59479541_59479891 0.51 JUN
jun proto-oncogene
229931
0.02
chr5_15499822_15500142 0.50 FBXL7
F-box and leucine-rich repeat protein 7
323
0.94
chr22_36231755_36232301 0.50 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
4237
0.32
chr4_77931733_77931884 0.49 SEPT11
septin 11
9877
0.24
chr8_107738861_107739281 0.48 OXR1
oxidation resistance 1
658
0.71
chr10_4284322_4284712 0.48 ENSG00000207124
.
272627
0.02
chr10_4285552_4285907 0.48 ENSG00000207124
.
271415
0.02
chrX_57848820_57848992 0.48 ZXDA
zinc finger, X-linked, duplicated A
88161
0.11
chrX_10737482_10738236 0.48 MID1
midline 1 (Opitz/BBB syndrome)
92080
0.1
chr5_141980216_141980760 0.48 AC005592.2

19075
0.18
chr21_47485234_47485853 0.47 AP001471.1

31901
0.13
chr2_164590053_164590372 0.47 FIGN
fidgetin
2305
0.48
chr6_27560724_27561227 0.47 ENSG00000206671
.
3216
0.27
chr6_128812548_128813040 0.47 RP1-86D1.5

8878
0.17
chr19_10927638_10927909 0.47 ENSG00000207752
.
399
0.76
chr18_65983753_65984295 0.47 TMX3
thioredoxin-related transmembrane protein 3
398270
0.01
chr9_97770438_97770821 0.47 C9orf3
chromosome 9 open reading frame 3
3351
0.26
chr4_175075425_175075781 0.47 FBXO8
F-box protein 8
129211
0.05
chr1_82265709_82265972 0.46 LPHN2
latrophilin 2
242
0.96
chr11_57529774_57530544 0.46 CTNND1
catenin (cadherin-associated protein), delta 1
869
0.5
chr12_32687758_32688027 0.46 FGD4
FYVE, RhoGEF and PH domain containing 4
634
0.8
chrY_7395772_7396011 0.46 ENSG00000252472
.
104692
0.07
chr12_66221036_66221187 0.46 HMGA2
high mobility group AT-hook 2
2208
0.34
chr6_7432189_7432426 0.45 CAGE1
cancer antigen 1
42331
0.14
chr6_112574305_112574456 0.45 LAMA4
laminin, alpha 4
1307
0.45
chr11_15991728_15991967 0.45 CTD-3096P4.1

52889
0.18
chr12_65996869_65997023 0.45 HMGA2
high mobility group AT-hook 2
220965
0.02
chr2_203883174_203883392 0.45 NBEAL1
neurobeachin-like 1
3681
0.28
chr3_141087883_141088209 0.45 RP11-438D8.2

2067
0.36
chr13_25245821_25246001 0.45 ATP12A
ATPase, H+/K+ transporting, nongastric, alpha polypeptide
8638
0.2
chr18_55890673_55891004 0.45 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
2035
0.39
chr6_19838575_19839711 0.44 RP1-167F1.2

168
0.95
chr6_1612835_1613496 0.44 FOXC1
forkhead box C1
2484
0.42
chr5_66156448_66156746 0.44 MAST4
microtubule associated serine/threonine kinase family member 4
31907
0.24
chr7_102470506_102470794 0.44 ENSG00000252643
.
4402
0.21
chr4_186577993_186578477 0.44 SORBS2
sorbin and SH3 domain containing 2
112
0.97
chr9_118918844_118919316 0.44 PAPPA
pregnancy-associated plasma protein A, pappalysin 1
2997
0.34
chr4_20253090_20253375 0.44 SLIT2
slit homolog 2 (Drosophila)
1651
0.55
chr9_16626345_16626809 0.43 RP11-62F24.1

903
0.71
chr21_47520199_47520351 0.43 COL6A2
collagen, type VI, alpha 2
1564
0.29
chr22_46478725_46478917 0.43 FLJ27365
hsa-mir-4763
2629
0.15
chr11_16023597_16024065 0.43 CTD-3096P4.1

20905
0.28
chr1_107684305_107684780 0.43 NTNG1
netrin G1
881
0.74
chr10_3977780_3978372 0.43 KLF6
Kruppel-like factor 6
150603
0.04
chr16_86603298_86603475 0.43 RP11-463O9.5

2019
0.25
chr15_60684685_60685107 0.42 ANXA2
annexin A2
1400
0.54
chr12_88812633_88812784 0.42 ENSG00000199245
.
11511
0.3
chr12_19392736_19392931 0.42 PLEKHA5
pleckstrin homology domain containing, family A member 5
2975
0.32
chr18_59272997_59273487 0.42 CDH20
cadherin 20, type 2
56143
0.17
chr16_4422135_4423224 0.42 VASN
vasorin
830
0.49
chr5_141667234_141667739 0.42 SPRY4
sprouty homolog 4 (Drosophila)
36261
0.18
chr20_36888419_36888669 0.42 BPI
bactericidal/permeability-increasing protein
7
0.93
chr12_20365488_20365686 0.42 PDE3A
phosphodiesterase 3A, cGMP-inhibited
156592
0.04
chr7_80547175_80548098 0.42 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
863
0.76
chr1_52362854_52363005 0.42 ENSG00000265769
.
3714
0.18
chr6_45500705_45501442 0.41 RUNX2
runt-related transcription factor 2
110851
0.06
chr1_60031328_60031726 0.41 FGGY
FGGY carbohydrate kinase domain containing
11937
0.3
chr1_63212144_63212320 0.41 ATG4C
autophagy related 4C, cysteine peptidase
37574
0.17
chr18_51780819_51781029 0.41 POLI
polymerase (DNA directed) iota
14850
0.19
chr20_50478304_50478696 0.41 ENSG00000252467
.
40330
0.14
chr3_100711576_100712203 0.41 ABI3BP
ABI family, member 3 (NESH) binding protein
408
0.89
chr4_90674612_90674925 0.41 RP11-115D19.1

72105
0.11
chr1_220700886_220701420 0.41 MARK1
MAP/microtubule affinity-regulating kinase 1
415
0.88
chr13_37934950_37935173 0.41 ENSG00000202395
.
194266
0.03
chr8_77586350_77586717 0.40 ZFHX4
zinc finger homeobox 4
6921
0.24
chr7_130849148_130849372 0.40 LINC-PINT
long intergenic non-protein coding RNA, p53 induced transcript
54325
0.14
chr10_16870751_16871209 0.40 RSU1
Ras suppressor protein 1
11453
0.28
chr15_93615075_93616283 0.40 RGMA
repulsive guidance molecule family member a
695
0.78
chr5_54456050_54456451 0.40 GPX8
glutathione peroxidase 8 (putative)
252
0.86
chr12_91575790_91576058 0.40 DCN
decorin
505
0.87
chr12_66222342_66222753 0.39 HMGA2
high mobility group AT-hook 2
3644
0.26
chr2_134325837_134326056 0.39 NCKAP5
NCK-associated protein 5
85
0.98
chr16_55513844_55514378 0.39 MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
201
0.95
chr1_234858581_234858939 0.39 IRF2BP2
interferon regulatory factor 2 binding protein 2
113489
0.06
chr5_36302348_36302599 0.39 RANBP3L
RAN binding protein 3-like
257
0.94
chr6_98074983_98075489 0.39 MMS22L
MMS22-like, DNA repair protein
344184
0.01
chr10_69831641_69832005 0.39 HERC4
HECT and RLD domain containing E3 ubiquitin protein ligase 4
2071
0.33
chr6_17101754_17102792 0.39 STMND1
stathmin domain containing 1
216
0.97
chr1_221509112_221509492 0.39 DUSP10
dual specificity phosphatase 10
401500
0.01
chr18_74322772_74323202 0.38 LINC00908
long intergenic non-protein coding RNA 908
82113
0.09
chr3_11279730_11279909 0.38 HRH1
histamine receptor H1
12102
0.25
chr3_55519561_55519953 0.38 WNT5A
wingless-type MMTV integration site family, member 5A
1574
0.4
chr11_12849275_12849529 0.38 RP11-47J17.3

4188
0.23
chr6_71108890_71109173 0.38 FAM135A
family with sequence similarity 135, member A
13980
0.21
chr12_47471040_47471191 0.38 PCED1B
PC-esterase domain containing 1B
2271
0.31
chr4_113739998_113740296 0.38 ANK2
ankyrin 2, neuronal
882
0.65
chr9_109622995_109623671 0.38 ZNF462
zinc finger protein 462
2045
0.37
chr6_21597329_21597632 0.38 SOX4
SRY (sex determining region Y)-box 4
3409
0.4
chr12_81107642_81108263 0.38 MYF5
myogenic factor 5
2739
0.29
chr5_54456456_54456818 0.38 GPX8
glutathione peroxidase 8 (putative)
639
0.58
chr10_15126072_15126273 0.37 ACBD7
acyl-CoA binding domain containing 7
4603
0.18
chr10_116755612_116755763 0.37 ENSG00000252611
.
26360
0.22
chr12_105477554_105478290 0.37 ALDH1L2
aldehyde dehydrogenase 1 family, member L2
419
0.81
chr10_33964074_33964254 0.37 NRP1
neuropilin 1
338974
0.01
chr6_28183539_28183724 0.37 ZSCAN9
zinc finger and SCAN domain containing 9
9033
0.14
chr3_57529834_57530279 0.37 DNAH12
dynein, axonemal, heavy chain 12
12
0.96
chr11_74465857_74466043 0.37 ENSG00000264095
.
1321
0.35
chr7_18392248_18392431 0.37 ENSG00000223030
.
55377
0.14
chr11_120195755_120196855 0.37 TMEM136
transmembrane protein 136
289
0.9
chr12_23088184_23088587 0.37 ETNK1
ethanolamine kinase 1
310094
0.01
chr14_69443190_69443341 0.37 ACTN1
actinin, alpha 1
1018
0.56
chr9_14251177_14251439 0.37 NFIB
nuclear factor I/B
56704
0.15
chr17_9018882_9019405 0.37 NTN1
netrin 1
47109
0.15
chr1_172291717_172291930 0.37 ENSG00000252354
.
25460
0.18
chr21_36337524_36338023 0.37 RUNX1
runt-related transcription factor 1
75686
0.12
chr12_66341710_66342532 0.37 RP11-366L20.3

138
0.96
chr4_30727648_30727863 0.37 PCDH7
protocadherin 7
3778
0.36
chr5_39424296_39424549 0.36 DAB2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
548
0.85
chr7_143581670_143581927 0.36 FAM115A
family with sequence similarity 115, member A
665
0.7
chr6_47755744_47755976 0.36 OPN5
opsin 5
6057
0.24
chr18_53089837_53090372 0.36 TCF4
transcription factor 4
361
0.89
chr2_207077876_207078071 0.36 GPR1
G protein-coupled receptor 1
122
0.95
chr1_21417128_21417631 0.36 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
1678
0.46
chrX_3379552_3379735 0.36 ENSG00000212214
.
70649
0.11
chr19_45995836_45996758 0.36 RTN2
reticulon 2
228
0.87
chr9_130341109_130341430 0.36 FAM129B
family with sequence similarity 129, member B
1
0.98
chr13_98953824_98954093 0.36 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
30054
0.16
chr1_179096167_179096689 0.36 ABL2
c-abl oncogene 2, non-receptor tyrosine kinase
15751
0.19
chr10_4734015_4734166 0.36 AKR1E2
aldo-keto reductase family 1, member E2
94731
0.08
chr12_119613928_119614269 0.36 RP11-64B16.3

191
0.93
chr1_68639626_68639844 0.35 ENSG00000221203
.
9558
0.22
chr3_175389807_175390608 0.35 ENSG00000201648
.
62940
0.12
chr19_2024353_2024504 0.35 ENSG00000265900
.
4099
0.12
chr18_52990549_52990700 0.35 TCF4
transcription factor 4
1099
0.65
chr7_17720120_17720505 0.35 SNX13
sorting nexin 13
259779
0.02
chr1_205343675_205343983 0.35 LEMD1-AS1
LEMD1 antisense RNA 1
1449
0.37
chr1_57045565_57045824 0.35 PPAP2B
phosphatidic acid phosphatase type 2B
453
0.89
chr9_130504383_130504534 0.35 TOR2A
torsin family 2, member A
6854
0.1
chr3_149093552_149093860 0.35 TM4SF1
transmembrane 4 L six family member 1
207
0.92
chr7_100774271_100774452 0.35 SERPINE1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
3982
0.12
chr5_121417237_121417571 0.35 LOX
lysyl oxidase
3424
0.28
chr6_117920563_117920770 0.34 GOPC
golgi-associated PDZ and coiled-coil motif containing
2861
0.34
chr6_163838395_163838889 0.34 QKI
QKI, KH domain containing, RNA binding
1295
0.63
chr5_66255088_66255484 0.34 MAST4
microtubule associated serine/threonine kinase family member 4
470
0.88
chr19_39465324_39465724 0.34 FBXO17
F-box protein 17
1026
0.37
chr2_236401822_236402641 0.34 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
502
0.83
chr14_52116783_52117087 0.34 FRMD6
FERM domain containing 6
1641
0.39
chr15_73050031_73050325 0.34 ADPGK
ADP-dependent glucokinase
1838
0.32
chr11_86512357_86512728 0.34 PRSS23
protease, serine, 23
957
0.7
chr14_68466602_68466753 0.34 CTD-2566J3.1

130236
0.05
chr6_148664293_148664728 0.34 SASH1
SAM and SH3 domain containing 1
781
0.74
chr13_24001777_24002309 0.34 SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
5798
0.32
chr10_119303944_119304573 0.34 EMX2OS
EMX2 opposite strand/antisense RNA
321
0.88
chr20_9048816_9049419 0.34 PLCB4
phospholipase C, beta 4
293
0.9
chr3_149224347_149224520 0.34 ENSG00000252581
.
18985
0.18
chr4_105416319_105416884 0.33 CXXC4
CXXC finger protein 4
550
0.77
chr9_132428871_132429094 0.33 PRRX2
paired related homeobox 2
1062
0.42
chr6_166446147_166446315 0.33 ENSG00000231297
.
67110
0.11
chr18_51675978_51676321 0.33 ENSG00000221058
.
63123
0.12
chr20_55377357_55377591 0.33 ENSG00000207158
.
16331
0.23
chr6_27584810_27585278 0.33 ENSG00000238648
.
14144
0.19
chr6_131291045_131291463 0.33 EPB41L2
erythrocyte membrane protein band 4.1-like 2
369
0.93

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of FOXD3_FOXI1_FOXF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.3 1.3 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.3 0.9 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.3 0.9 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 0.7 GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.2 0.4 GO:0031223 auditory behavior(GO:0031223)
0.2 0.8 GO:0048342 paraxial mesodermal cell differentiation(GO:0048342) paraxial mesodermal cell fate commitment(GO:0048343)
0.2 0.6 GO:0035385 Roundabout signaling pathway(GO:0035385)
0.2 0.8 GO:0043589 skin morphogenesis(GO:0043589)
0.2 0.7 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.2 0.5 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.1 0.6 GO:0048149 behavioral response to ethanol(GO:0048149)
0.1 0.3 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.1 0.6 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.1 0.4 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.1 0.5 GO:0010662 striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.1 0.4 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.1 0.6 GO:0060638 mesenchymal-epithelial cell signaling(GO:0060638)
0.1 0.4 GO:0060596 mammary placode formation(GO:0060596)
0.1 0.5 GO:0072268 pattern specification involved in metanephros development(GO:0072268)
0.1 0.7 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.1 0.2 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.1 0.3 GO:0051451 myoblast migration(GO:0051451)
0.1 0.4 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.1 0.7 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1 0.6 GO:0016264 gap junction assembly(GO:0016264)
0.1 0.1 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 0.3 GO:0035581 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1 0.5 GO:0060347 heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.1 0.3 GO:1903054 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.1 0.2 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.1 0.4 GO:0060997 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.1 0.4 GO:0009169 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.1 0.3 GO:0052166 pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308)
0.1 0.2 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 0.2 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.1 0.6 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 0.3 GO:0060754 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.1 0.8 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.1 0.2 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.1 0.3 GO:0060685 regulation of prostatic bud formation(GO:0060685)
0.1 0.1 GO:0007501 mesodermal cell fate specification(GO:0007501)
0.1 0.2 GO:0008049 male courtship behavior(GO:0008049)
0.1 0.4 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.1 0.2 GO:0048368 lateral mesoderm development(GO:0048368)
0.1 0.1 GO:0032353 regulation of ketone biosynthetic process(GO:0010566) regulation of glucocorticoid biosynthetic process(GO:0031946) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347) negative regulation of hormone metabolic process(GO:0032351) negative regulation of hormone biosynthetic process(GO:0032353) regulation of steroid hormone biosynthetic process(GO:0090030)
0.1 0.7 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.1 0.2 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.1 0.4 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.1 0.1 GO:0003308 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.1 0.2 GO:0070933 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.1 0.4 GO:0042984 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.1 0.4 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.1 0.1 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.1 0.1 GO:0061318 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.1 0.3 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.1 0.7 GO:0035329 hippo signaling(GO:0035329)
0.1 0.3 GO:0002063 chondrocyte development(GO:0002063)
0.1 0.3 GO:0050932 regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.1 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.1 GO:0009996 negative regulation of cell fate specification(GO:0009996)
0.1 0.5 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.1 0.2 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.1 0.2 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.1 0.3 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.1 0.1 GO:0016576 histone dephosphorylation(GO:0016576)
0.1 0.6 GO:0001738 morphogenesis of a polarized epithelium(GO:0001738)
0.1 0.1 GO:0010002 cardioblast differentiation(GO:0010002)
0.1 0.2 GO:0015889 cobalamin transport(GO:0015889)
0.1 0.2 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.1 0.3 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.1 0.1 GO:0002248 connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.1 0.1 GO:0031529 ruffle organization(GO:0031529)
0.1 0.3 GO:0032288 myelin assembly(GO:0032288)
0.1 0.1 GO:0044413 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1 0.2 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.1 0.1 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.1 0.3 GO:0042693 muscle cell fate commitment(GO:0042693)
0.1 0.4 GO:0002076 osteoblast development(GO:0002076)
0.1 0.3 GO:0048520 positive regulation of behavior(GO:0048520)
0.1 0.2 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1 0.3 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 0.1 GO:0033688 regulation of osteoblast proliferation(GO:0033688)
0.1 0.1 GO:0032455 nerve growth factor processing(GO:0032455)
0.1 0.2 GO:0001778 plasma membrane repair(GO:0001778)
0.1 0.1 GO:0061299 retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1 0.1 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.1 0.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.1 0.2 GO:0021615 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.1 0.1 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.1 0.2 GO:0046952 ketone body catabolic process(GO:0046952)
0.1 0.1 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.2 GO:0070141 response to UV-A(GO:0070141)
0.0 0.8 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.2 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0 0.1 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.1 GO:0010842 retina layer formation(GO:0010842)
0.0 0.2 GO:0008354 germ cell migration(GO:0008354)
0.0 0.1 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 1.2 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.0 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.9 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.1 GO:0051280 negative regulation of ion transmembrane transporter activity(GO:0032413) negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0 0.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.1 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.0 0.1 GO:0021800 cerebral cortex tangential migration(GO:0021800)
0.0 0.1 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.0 0.4 GO:0031000 response to caffeine(GO:0031000)
0.0 0.1 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.0 GO:0061364 apoptotic process involved in luteolysis(GO:0061364)
0.0 0.1 GO:0007132 meiotic metaphase I(GO:0007132)
0.0 0.0 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0 0.0 GO:0061213 positive regulation of mesonephros development(GO:0061213) regulation of mesonephros development(GO:0061217) regulation of branching involved in ureteric bud morphogenesis(GO:0090189) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.0 0.1 GO:0060453 regulation of gastric acid secretion(GO:0060453)
0.0 0.1 GO:0045978 negative regulation of nucleoside metabolic process(GO:0045978) negative regulation of ATP metabolic process(GO:1903579)
0.0 0.0 GO:0033630 positive regulation of cell adhesion mediated by integrin(GO:0033630)
0.0 0.1 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.1 GO:0039656 modulation by virus of host gene expression(GO:0039656)
0.0 0.3 GO:0007494 midgut development(GO:0007494)
0.0 0.2 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 0.1 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.0 0.2 GO:0097094 cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0 0.5 GO:0008589 regulation of smoothened signaling pathway(GO:0008589)
0.0 0.1 GO:0051549 regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0 0.3 GO:0060039 pericardium development(GO:0060039)
0.0 0.2 GO:0055057 neuronal stem cell division(GO:0036445) neuroblast division(GO:0055057)
0.0 0.3 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.0 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0 0.2 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.1 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.1 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.0 GO:0060242 contact inhibition(GO:0060242)
0.0 1.8 GO:0034332 adherens junction organization(GO:0034332)
0.0 0.2 GO:0090399 replicative senescence(GO:0090399)
0.0 0.6 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.1 GO:0048245 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0 0.2 GO:0008634 obsolete negative regulation of survival gene product expression(GO:0008634)
0.0 0.1 GO:0035929 steroid hormone secretion(GO:0035929)
0.0 0.5 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
0.0 0.1 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0 0.2 GO:0032410 negative regulation of transporter activity(GO:0032410)
0.0 0.3 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.0 GO:0007440 foregut morphogenesis(GO:0007440)
0.0 0.2 GO:0007350 blastoderm segmentation(GO:0007350)
0.0 0.0 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.1 GO:0002829 negative regulation of type 2 immune response(GO:0002829)
0.0 0.5 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.5 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.1 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.4 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.0 0.1 GO:0010107 potassium ion import(GO:0010107)
0.0 0.1 GO:0031953 negative regulation of protein autophosphorylation(GO:0031953)
0.0 0.1 GO:0010092 specification of organ identity(GO:0010092)
0.0 0.0 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0 0.0 GO:0061072 iris morphogenesis(GO:0061072)
0.0 0.5 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.0 GO:0046628 positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0 0.0 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0 0.1 GO:0050955 thermoception(GO:0050955)
0.0 0.2 GO:0032330 regulation of chondrocyte differentiation(GO:0032330)
0.0 0.1 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:0060677 ureteric bud elongation(GO:0060677)
0.0 0.1 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0 0.3 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.0 0.1 GO:0085029 extracellular matrix assembly(GO:0085029)
0.0 0.0 GO:0072193 ureter development(GO:0072189) ureter smooth muscle development(GO:0072191) ureter smooth muscle cell differentiation(GO:0072193)
0.0 0.2 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.1 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.2 GO:0031017 exocrine pancreas development(GO:0031017)
0.0 0.2 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.3 GO:0060042 retina morphogenesis in camera-type eye(GO:0060042)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.0 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.0 0.1 GO:0014850 response to muscle activity(GO:0014850)
0.0 0.2 GO:0030238 male sex determination(GO:0030238)
0.0 1.4 GO:0071773 BMP signaling pathway(GO:0030509) response to BMP(GO:0071772) cellular response to BMP stimulus(GO:0071773)
0.0 0.1 GO:0032776 DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0 0.1 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.3 GO:0045749 obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0 0.1 GO:0035413 positive regulation of catenin import into nucleus(GO:0035413)
0.0 0.5 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.2 GO:0032717 negative regulation of interleukin-8 production(GO:0032717)
0.0 0.1 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.0 0.2 GO:1904888 cranial skeletal system development(GO:1904888)
0.0 0.1 GO:0021978 telencephalon regionalization(GO:0021978)
0.0 0.1 GO:0043116 negative regulation of vascular permeability(GO:0043116)
0.0 0.2 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.1 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0 0.2 GO:0000052 citrulline metabolic process(GO:0000052)
0.0 0.0 GO:0060013 righting reflex(GO:0060013)
0.0 0.1 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.0 0.2 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 0.2 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.1 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.1 GO:0048712 negative regulation of astrocyte differentiation(GO:0048712)
0.0 0.6 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.1 GO:0016198 axon choice point recognition(GO:0016198)
0.0 0.1 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 0.1 GO:0045103 intermediate filament-based process(GO:0045103)
0.0 0.2 GO:0009629 response to gravity(GO:0009629)
0.0 0.1 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.0 0.1 GO:0032730 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730)
0.0 0.0 GO:0070254 mucus secretion(GO:0070254)
0.0 0.1 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.0 GO:0010966 regulation of phosphate transport(GO:0010966)
0.0 0.3 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.0 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 0.0 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0 0.1 GO:0055075 potassium ion homeostasis(GO:0055075)
0.0 0.1 GO:0006533 aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.0 0.1 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.1 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.2 GO:0000768 syncytium formation by plasma membrane fusion(GO:0000768) myoblast fusion(GO:0007520)
0.0 0.2 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.0 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 0.1 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.2 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.0 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 0.0 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.0 0.1 GO:0032236 obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0 0.1 GO:0045989 positive regulation of striated muscle contraction(GO:0045989)
0.0 0.0 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.0 0.1 GO:0010834 obsolete telomere maintenance via telomere shortening(GO:0010834)
0.0 0.0 GO:0043129 surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0 0.2 GO:0007628 adult walking behavior(GO:0007628) walking behavior(GO:0090659)
0.0 0.1 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.1 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.0 0.1 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 0.1 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 0.1 GO:0001885 endothelial cell development(GO:0001885)
0.0 0.0 GO:0016081 synaptic vesicle docking(GO:0016081)
0.0 0.2 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.1 GO:0071731 response to nitric oxide(GO:0071731)
0.0 0.0 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.0 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
0.0 0.1 GO:0001660 fever generation(GO:0001660)
0.0 0.0 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.0 0.0 GO:0060687 regulation of branching involved in prostate gland morphogenesis(GO:0060687)
0.0 0.0 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.0 0.0 GO:0032226 positive regulation of synaptic transmission, dopaminergic(GO:0032226)
0.0 0.1 GO:0031427 response to methotrexate(GO:0031427)
0.0 0.0 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.1 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.0 0.4 GO:0098773 hair follicle development(GO:0001942) molting cycle process(GO:0022404) hair cycle process(GO:0022405) skin epidermis development(GO:0098773)
0.0 0.1 GO:0015802 basic amino acid transport(GO:0015802)
0.0 0.0 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0 0.1 GO:0035567 non-canonical Wnt signaling pathway(GO:0035567)
0.0 0.2 GO:0048566 embryonic digestive tract development(GO:0048566)
0.0 0.2 GO:0045995 regulation of embryonic development(GO:0045995)
0.0 0.1 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.0 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 0.1 GO:0007530 sex determination(GO:0007530)
0.0 0.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.1 GO:0051938 L-glutamate import(GO:0051938)
0.0 0.1 GO:0034629 cellular protein complex localization(GO:0034629)
0.0 0.1 GO:0009111 vitamin catabolic process(GO:0009111) fat-soluble vitamin catabolic process(GO:0042363)
0.0 0.1 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.0 0.1 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.2 GO:0050766 positive regulation of phagocytosis(GO:0050766)
0.0 1.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.2 GO:0007492 endoderm development(GO:0007492)
0.0 0.0 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.3 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 0.0 GO:0001547 antral ovarian follicle growth(GO:0001547)
0.0 0.0 GO:0003151 outflow tract morphogenesis(GO:0003151)
0.0 0.1 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0 0.0 GO:0097576 vacuole fusion(GO:0097576)
0.0 0.3 GO:0001843 neural tube closure(GO:0001843)
0.0 0.0 GO:0071462 cellular response to water stimulus(GO:0071462)
0.0 0.0 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.1 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.0 0.0 GO:0060291 long-term synaptic potentiation(GO:0060291)
0.0 0.1 GO:0043113 receptor clustering(GO:0043113)
0.0 0.0 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)
0.0 0.0 GO:0006590 thyroid hormone generation(GO:0006590)
0.0 0.0 GO:0010613 positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.0 0.1 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.0 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 0.1 GO:0052805 histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0 0.1 GO:0048286 lung alveolus development(GO:0048286)
0.0 0.1 GO:0007413 axonal fasciculation(GO:0007413)
0.0 0.1 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.2 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway(GO:0090101)
0.0 0.6 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 0.3 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.0 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.0 GO:0009950 dorsal/ventral axis specification(GO:0009950)
0.0 0.0 GO:0010919 regulation of inositol phosphate biosynthetic process(GO:0010919) positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.0 0.1 GO:0044550 secondary metabolite biosynthetic process(GO:0044550)
0.0 0.0 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.0 0.0 GO:0018242 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.0 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.0 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 0.0 GO:0060992 response to fungicide(GO:0060992)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.1 GO:0007224 smoothened signaling pathway(GO:0007224)
0.0 0.1 GO:0019228 neuronal action potential(GO:0019228)
0.0 0.1 GO:0060350 endochondral bone morphogenesis(GO:0060350)
0.0 0.0 GO:0000492 small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0 0.1 GO:0006621 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0 0.1 GO:0060134 prepulse inhibition(GO:0060134)
0.0 0.1 GO:0006942 regulation of striated muscle contraction(GO:0006942)
0.0 1.1 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.0 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.0 0.0 GO:0051788 response to misfolded protein(GO:0051788)
0.0 0.0 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.1 GO:0007340 acrosome reaction(GO:0007340)
0.0 0.0 GO:0001945 lymph vessel development(GO:0001945)
0.0 0.1 GO:0008211 glucocorticoid metabolic process(GO:0008211)
0.0 0.0 GO:0014741 negative regulation of muscle hypertrophy(GO:0014741)
0.0 0.1 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.0 GO:0042574 retinal metabolic process(GO:0042574)
0.0 0.0 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367)
0.0 0.1 GO:0009103 lipopolysaccharide biosynthetic process(GO:0009103)
0.0 0.0 GO:0002667 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.0 GO:0043584 nose development(GO:0043584)
0.0 0.0 GO:0071549 cellular response to dexamethasone stimulus(GO:0071549)
0.0 0.1 GO:0009404 toxin metabolic process(GO:0009404)
0.0 0.0 GO:0061525 hindgut morphogenesis(GO:0007442) hindgut development(GO:0061525)
0.0 0.0 GO:0070874 negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.1 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0 0.0 GO:0021513 spinal cord dorsal/ventral patterning(GO:0021513)
0.0 0.0 GO:0002062 chondrocyte differentiation(GO:0002062)
0.0 0.0 GO:0009822 alkaloid catabolic process(GO:0009822)
0.0 0.1 GO:0002675 positive regulation of acute inflammatory response(GO:0002675)
0.0 0.1 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0 0.0 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0 0.0 GO:0055089 fatty acid homeostasis(GO:0055089)
0.0 0.0 GO:0046476 glycosylceramide biosynthetic process(GO:0046476)
0.0 0.1 GO:0014003 oligodendrocyte development(GO:0014003)
0.0 0.0 GO:0061036 positive regulation of cartilage development(GO:0061036)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.2 1.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 1.1 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.2 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.1 0.8 GO:0005916 fascia adherens(GO:0005916)
0.1 1.0 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.5 GO:0071437 invadopodium(GO:0071437)
0.1 0.4 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.3 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.5 GO:0005606 laminin-1 complex(GO:0005606)
0.1 0.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.2 GO:0005899 insulin receptor complex(GO:0005899)
0.1 0.3 GO:0043218 compact myelin(GO:0043218)
0.1 0.5 GO:0098642 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.1 0.1 GO:0014704 intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.1 0.2 GO:0070852 cell body fiber(GO:0070852)
0.1 0.2 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.1 1.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 0.4 GO:0005577 fibrinogen complex(GO:0005577)
0.1 1.0 GO:0005811 lipid particle(GO:0005811)
0.1 0.5 GO:0008091 spectrin(GO:0008091)
0.1 0.3 GO:0031512 motile primary cilium(GO:0031512)
0.0 0.3 GO:0001527 microfibril(GO:0001527)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 4.6 GO:0030016 myofibril(GO:0030016)
0.0 0.1 GO:0032432 actin filament bundle(GO:0032432)
0.0 0.2 GO:0016012 dystroglycan complex(GO:0016011) sarcoglycan complex(GO:0016012)
0.0 0.7 GO:0032589 neuron projection membrane(GO:0032589)
0.0 0.2 GO:0042587 glycogen granule(GO:0042587)
0.0 1.7 GO:0005604 basement membrane(GO:0005604)
0.0 0.2 GO:0010369 chromocenter(GO:0010369)
0.0 2.1 GO:0030426 growth cone(GO:0030426)
0.0 0.2 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.4 GO:0005581 collagen trimer(GO:0005581)
0.0 0.1 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.1 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826) contractile ring(GO:0070938)
0.0 0.1 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.1 GO:0044447 axoneme part(GO:0044447)
0.0 0.2 GO:0031941 filamentous actin(GO:0031941)
0.0 5.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.1 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 0.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.2 GO:0030315 T-tubule(GO:0030315)
0.0 0.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.2 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.1 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.5 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.0 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.2 GO:0030122 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0 3.0 GO:0005911 cell-cell junction(GO:0005911)
0.0 0.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.0 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.1 GO:0008328 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.2 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.5 GO:0043197 dendritic spine(GO:0043197)
0.0 0.0 GO:0044309 neuron spine(GO:0044309)
0.0 0.1 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.2 GO:0090533 cation-transporting ATPase complex(GO:0090533)
0.0 0.0 GO:0002139 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0 0.2 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.5 GO:0016459 myosin complex(GO:0016459)
0.0 0.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.1 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.3 GO:0030286 dynein complex(GO:0030286)
0.0 0.3 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.1 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.1 GO:0002102 podosome(GO:0002102)
0.0 1.1 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.1 GO:0005655 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.0 0.1 GO:0000153 cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0 0.1 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.0 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.0 GO:0042597 outer membrane-bounded periplasmic space(GO:0030288) periplasmic space(GO:0042597)
0.0 0.1 GO:0030127 COPII vesicle coat(GO:0030127)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0000987 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.3 1.0 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.3 0.9 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 0.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 1.6 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.2 0.7 GO:0045499 chemorepellent activity(GO:0045499)
0.2 0.3 GO:0050682 AF-2 domain binding(GO:0050682)
0.2 0.7 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.2 0.8 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.2 0.9 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.1 0.4 GO:0042577 lipid phosphatase activity(GO:0042577)
0.1 1.1 GO:0017166 vinculin binding(GO:0017166)
0.1 0.5 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1 0.4 GO:0045545 syndecan binding(GO:0045545)
0.1 0.8 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 0.5 GO:0048495 Roundabout binding(GO:0048495)
0.1 0.3 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.3 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.1 0.4 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.1 0.7 GO:0005110 frizzled-2 binding(GO:0005110)
0.1 0.3 GO:0031177 phosphopantetheine binding(GO:0031177)
0.1 0.3 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 0.2 GO:0048018 receptor agonist activity(GO:0048018)
0.1 0.3 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.4 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.1 0.4 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 1.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 1.1 GO:0001968 fibronectin binding(GO:0001968)
0.1 0.3 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.1 1.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 1.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 1.0 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.2 GO:0034056 estrogen response element binding(GO:0034056)
0.1 0.4 GO:0051636 obsolete Gram-negative bacterial cell surface binding(GO:0051636)
0.1 0.2 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.1 0.3 GO:0016361 activin receptor activity, type I(GO:0016361)
0.1 0.2 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 0.3 GO:0031994 insulin-like growth factor I binding(GO:0031994)
0.1 0.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 0.5 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 0.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 0.2 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.1 0.1 GO:0017002 activin receptor activity, type II(GO:0016362) activin-activated receptor activity(GO:0017002)
0.1 0.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 0.2 GO:0016623 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.1 0.2 GO:0042805 actinin binding(GO:0042805)
0.1 0.2 GO:0016882 cyclo-ligase activity(GO:0016882)
0.1 0.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 1.2 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 0.3 GO:0030507 spectrin binding(GO:0030507)
0.1 0.2 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.2 GO:0004470 malic enzyme activity(GO:0004470)
0.1 0.3 GO:0044390 ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.1 0.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.1 GO:0070215 obsolete MDM2 binding(GO:0070215)
0.0 0.2 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.2 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.2 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.2 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.0 0.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.5 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 1.3 GO:0005518 collagen binding(GO:0005518)
0.0 0.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.5 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.1 GO:0001601 peptide YY receptor activity(GO:0001601)
0.0 0.1 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.2 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.1 GO:0005534 galactose binding(GO:0005534)
0.0 0.1 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.2 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.1 GO:0005113 patched binding(GO:0005113)
0.0 0.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.1 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.2 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.4 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.2 GO:0048185 activin binding(GO:0048185)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.1 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.3 GO:0043498 obsolete cell surface binding(GO:0043498)
0.0 0.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.1 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.3 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.2 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.1 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.1 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.1 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.4 GO:0045296 cadherin binding(GO:0045296)
0.0 0.1 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.2 GO:0008430 selenium binding(GO:0008430)
0.0 0.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.1 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.2 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.1 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 1.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.1 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0 0.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.2 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 0.1 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 2.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.4 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.1 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.2 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.1 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0 0.0 GO:0032052 bile acid binding(GO:0032052)
0.0 0.2 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.1 GO:0030955 potassium ion binding(GO:0030955)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0017089 glycolipid transporter activity(GO:0017089)
0.0 0.1 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.1 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.1 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.1 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.2 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.1 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.2 GO:0001619 obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0 0.0 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.2 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.0 0.0 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.0 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 0.1 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.8 GO:0051015 actin filament binding(GO:0051015)
0.0 0.1 GO:0004083 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0 0.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.1 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.0 0.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.1 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.0 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.0 GO:0051425 PTB domain binding(GO:0051425)
0.0 0.0 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.0 0.0 GO:0034584 piRNA binding(GO:0034584)
0.0 0.1 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.1 GO:0042171 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 0.0 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.0 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0 0.0 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.0 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.0 GO:0033765 steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0 0.1 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 0.0 GO:0005148 prolactin receptor binding(GO:0005148)
0.0 0.0 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.1 GO:0048019 receptor antagonist activity(GO:0048019)
0.0 0.2 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.1 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.0 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.1 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 3.1 GO:0030528 obsolete transcription regulator activity(GO:0030528)
0.0 0.0 GO:0034187 obsolete apolipoprotein E binding(GO:0034187)
0.0 0.1 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0 0.1 GO:0001228 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.0 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.0 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.1 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.0 GO:0032554 purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0 0.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.1 GO:0005109 frizzled binding(GO:0005109)
0.0 0.2 GO:0004970 ionotropic glutamate receptor activity(GO:0004970)
0.0 0.2 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.0 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 PID SHP2 PATHWAY SHP2 signaling
0.1 2.4 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 0.1 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.1 1.8 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 0.9 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 0.5 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 2.7 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.2 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.2 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.4 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.3 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.0 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 1.2 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.0 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 1.2 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.2 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.8 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.1 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 4.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.2 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.2 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.2 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.1 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.8 PID BMP PATHWAY BMP receptor signaling
0.0 0.7 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.4 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.0 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.6 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.7 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.0 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 0.0 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.3 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.1 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.3 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 2.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.0 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.1 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.1 ST G ALPHA I PATHWAY G alpha i Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 0.1 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 1.9 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.0 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 0.8 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.1 0.8 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 0.4 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 3.3 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 0.9 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 0.6 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.5 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.7 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.9 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.6 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.5 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.5 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.5 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.0 REACTOME PI 3K CASCADE Genes involved in PI-3K cascade
0.0 0.9 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.9 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.8 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.0 REACTOME PHOSPHOLIPASE C MEDIATED CASCADE Genes involved in Phospholipase C-mediated cascade
0.0 0.4 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.2 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.0 0.0 REACTOME SIGNALING BY FGFR Genes involved in Signaling by FGFR
0.0 0.0 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.1 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 0.2 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.5 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.3 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.0 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.0 REACTOME REGULATION OF APOPTOSIS Genes involved in Regulation of Apoptosis
0.0 0.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.1 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.3 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.3 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.2 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.2 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.0 0.1 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.1 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.2 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.0 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.3 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.4 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.1 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.2 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.2 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.4 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.0 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.1 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.4 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.1 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline