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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for FOXF2_FOXJ1

Z-value: 0.84

Motif logo

Transcription factors associated with FOXF2_FOXJ1

Gene Symbol	Gene ID	Gene Info
FOXF2 Ensembl NCBI GeneCards UniProt	ENSG00000137273.3	FOXF2
FOXJ1 Ensembl NCBI GeneCards UniProt	ENSG00000129654.7	FOXJ1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
FOXF2	chr6_1393770_1393965	3798	0.264951	-0.52	1.6e-01	Click!
FOXF2	chr6_1389874_1390147	59	0.978586	0.36	3.4e-01	Click!
FOXF2	chr6_1391347_1391718	1463	0.453743	0.29	4.5e-01	Click!
FOXF2	chr6_1392834_1392985	2840	0.298522	-0.27	4.8e-01	Click!
FOXF2	chr6_1407500_1407651	17506	0.209936	0.27	4.9e-01	Click!
FOXJ1	chr17_74137094_74137375	146	0.736402	-0.37	3.3e-01	Click!

Activity of the FOXF2_FOXJ1 motif across conditions

Conditions sorted by the z-value of the FOXF2_FOXJ1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr9_120466546_120467060	0.49	TLR4	toll-like receptor 4	153	0.96
chr8_15398472_15398721	0.49	TUSC3	tumor suppressor candidate 3	804	0.72
chr4_71587677_71588145	0.44	RUFY3	RUN and FYVE domain containing 3	183	0.92
chr8_107738861_107739281	0.35	OXR1	oxidation resistance 1	658	0.71
chr1_109913452_109914259	0.34	SORT1	sortilin 1	22124	0.14
chr5_59893443_59893927	0.34	DEPDC1B	DEP domain containing 1B	102276	0.07
chr7_19152184_19152434	0.34	AC003986.6		212	0.92
chr2_152214605_152215087	0.33	TNFAIP6	tumor necrosis factor, alpha-induced protein 6	740	0.63
chr10_13569706_13570278	0.32	RP11-214D15.2		524	0.45
chr7_79449658_79449850	0.32	ENSG00000206818	.	91770	0.09
chr2_27995563_27995714	0.30	MRPL33	mitochondrial ribosomal protein L33	1054	0.48
chr6_151648337_151648657	0.30	AKAP12	A kinase (PRKA) anchor protein 12	1674	0.27
chr9_128235766_128235975	0.30	MAPKAP1	mitogen-activated protein kinase associated protein 1	10910	0.23
chr6_44510355_44510599	0.29	ENSG00000266619	.	107099	0.06
chr1_216773992_216774229	0.28	ESRRG	estrogen-related receptor gamma	122564	0.06
chr4_115282272_115282768	0.28	UGT8	UDP glycosyltransferase 8	237091	0.02
chr6_132268442_132268593	0.28	RP11-69I8.3		3569	0.25
chr6_136223158_136223344	0.27	ENSG00000238921	.	12642	0.24
chr6_153269357_153269511	0.27	FBXO5	F-box protein 5	34719	0.14
chr8_48571824_48572102	0.27	SPIDR	scaffolding protein involved in DNA repair	263	0.93
chr3_59803963_59804385	0.27	NPCDR1	nasopharyngeal carcinoma, down-regulated 1	153409	0.05
chr7_19308580_19308778	0.25	FERD3L	Fer3-like bHLH transcription factor	123635	0.05
chr14_79747812_79748200	0.25	NRXN3	neurexin 3	1757	0.44
chr13_37493387_37493814	0.25	SMAD9	SMAD family member 9	775	0.69
chr18_25756118_25756718	0.24	CDH2	cadherin 2, type 1, N-cadherin (neuronal)	992	0.73
chr11_36616853_36617082	0.24	C11orf74	chromosome 11 open reading frame 74	567	0.5
chr19_54534469_54534642	0.24	VSTM1	V-set and transmembrane domain containing 1	27122	0.08
chr14_52707563_52708006	0.24	PTGDR	prostaglandin D2 receptor (DP)	26647	0.22
chr18_65983753_65984295	0.24	TMX3	thioredoxin-related transmembrane protein 3	398270	0.01
chr1_172110530_172111247	0.23	ENSG00000207949	.	2841	0.22
chr10_45473981_45474319	0.23	C10orf10	chromosome 10 open reading frame 10	87	0.95
chr12_21981553_21981788	0.23	RP11-729I10.2		1526	0.43
chr9_75486718_75486907	0.23	ALDH1A1	aldehyde dehydrogenase 1 family, member A1	81159	0.11
chr1_60031328_60031726	0.22	FGGY	FGGY carbohydrate kinase domain containing	11937	0.3
chr5_90515283_90515434	0.22	ENSG00000199643	.	51186	0.18
chr21_17442999_17443232	0.22	ENSG00000252273	.	35286	0.24
chr12_19392736_19392931	0.22	PLEKHA5	pleckstrin homology domain containing, family A member 5	2975	0.32
chr7_148232370_148232768	0.22	C7orf33	chromosome 7 open reading frame 33	55088	0.14
chr13_33803329_33803516	0.22	STARD13	StAR-related lipid transfer (START) domain containing 13	23279	0.2
chr2_45200338_45200489	0.21	SIX3-AS1	SIX3 antisense RNA 1	31401	0.17
chr10_49734527_49734828	0.21	ARHGAP22	Rho GTPase activating protein 22	2396	0.33
chr3_87039220_87039752	0.21	VGLL3	vestigial like 3 (Drosophila)	366	0.93
chr16_88628658_88628817	0.21	ZC3H18	zinc finger CCCH-type containing 18	8052	0.16
chr3_190530283_190530682	0.21	GMNC	geminin coiled-coil domain containing	49922	0.18
chr2_185461919_185462338	0.21	ZNF804A	zinc finger protein 804A	965	0.73
chr12_1583558_1583788	0.21	WNT5B	wingless-type MMTV integration site family, member 5B	55384	0.12
chr1_182931948_182932121	0.20	ENSG00000264768	.	3324	0.2
chr14_59215785_59216332	0.20	ENSG00000221427	.	21906	0.26
chr3_18153147_18153551	0.20	RP11-158G18.1		297778	0.01
chr22_36367515_36367713	0.20	RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	9900	0.29
chr16_25047588_25047739	0.20	ARHGAP17	Rho GTPase activating protein 17	20676	0.23
chr5_141980216_141980760	0.20	AC005592.2		19075	0.18
chr2_74104795_74104946	0.20	ACTG2	actin, gamma 2, smooth muscle, enteric	15224	0.17
chr15_61044545_61044696	0.20	RP11-554D20.1		11485	0.22
chr8_38855409_38855789	0.19	ADAM9	ADAM metallopeptidase domain 9	1094	0.34
chr7_27217405_27217623	0.19	RP1-170O19.20	Uncharacterized protein	2118	0.1
chr15_99864758_99865035	0.19	AC022819.2	Uncharacterized protein	5068	0.23
chr2_38008128_38008279	0.19	CDC42EP3	CDC42 effector protein (Rho GTPase binding) 3	42592	0.19
chr5_131893791_131893942	0.19	RAD50	RAD50 homolog (S. cerevisiae)	943	0.42
chr12_15038397_15038786	0.19	MGP	matrix Gla protein	200	0.92
chr15_85590935_85591086	0.19	PDE8A	phosphodiesterase 8A	65798	0.1
chr10_126843486_126843769	0.18	CTBP2	C-terminal binding protein 2	3658	0.35
chr8_48297219_48297488	0.18	SPIDR	scaffolding protein involved in DNA repair	55610	0.16
chr18_52990549_52990700	0.18	TCF4	transcription factor 4	1099	0.65
chr13_31481253_31481536	0.18	MEDAG	mesenteric estrogen-dependent adipogenesis	551	0.78
chr21_17584209_17584483	0.18	ENSG00000201025	.	72743	0.13
chr2_176992012_176992333	0.18	HOXD8	homeobox D8	2250	0.12
chr10_134389068_134389378	0.18	INPP5A	inositol polyphosphate-5-phosphatase, 40kDa	32207	0.18
chr1_198859885_198860036	0.18	ENSG00000207759	.	31678	0.2
chr3_119921742_119921893	0.18	ENSG00000206721	.	7350	0.22
chr20_9048816_9049419	0.18	PLCB4	phospholipase C, beta 4	293	0.9
chr7_127293840_127294146	0.18	SND1	staphylococcal nuclease and tudor domain containing 1	1759	0.28
chr21_28337250_28337401	0.18	ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif, 5	1507	0.46
chr5_123493061_123493232	0.18	CSNK1G3	casein kinase 1, gamma 3	569027	0.0
chr2_146281977_146282128	0.17	ENSG00000253036	.	189414	0.03
chr1_65730855_65731313	0.17	DNAJC6	DnaJ (Hsp40) homolog, subfamily C, member 6	647	0.77
chr2_63971666_63971817	0.17	ENSG00000221085	.	49072	0.16
chr3_114477226_114477377	0.17	ZBTB20	zinc finger and BTB domain containing 20	486	0.86
chr20_1103594_1103745	0.17	PSMF1	proteasome (prosome, macropain) inhibitor subunit 1 (PI31)	4389	0.25
chr2_43406321_43406536	0.17	ZFP36L2	ZFP36 ring finger protein-like 2	47320	0.15
chr3_186539235_186539386	0.17	RP11-573D15.3		13829	0.08
chr22_46988879_46989444	0.17	GRAMD4	GRAM domain containing 4	16135	0.21
chr5_67323714_67323865	0.17	ENSG00000223149	.	60516	0.15
chr3_9389156_9389527	0.17	THUMPD3	THUMP domain containing 3	15185	0.15
chr3_73769050_73769270	0.17	PDZRN3	PDZ domain containing ring finger 3	95069	0.08
chr6_113970392_113970641	0.17	ENSG00000266650	.	46399	0.16
chr12_30947588_30947773	0.17	CAPRIN2	caprin family member 2	39795	0.19
chr11_57529774_57530544	0.17	CTNND1	catenin (cadherin-associated protein), delta 1	869	0.5
chr8_42394798_42395191	0.17	SLC20A2	solute carrier family 20 (phosphate transporter), member 2	1203	0.3
chr13_73712912_73713063	0.16	ENSG00000265959	.	14040	0.19
chr9_110400851_110401256	0.16	ENSG00000202308	.	24474	0.24
chr13_21790667_21790818	0.16	MRP63	mitochondrial ribosomal protein 63	39958	0.12
chr16_67512921_67513072	0.16	ATP6V0D1	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1	1986	0.17
chr12_76144582_76144847	0.16	ENSG00000264062	.	26393	0.22
chr3_15847185_15847355	0.16	ANKRD28	ankyrin repeat domain 28	9242	0.22
chrX_22318596_22318928	0.16	ZNF645	zinc finger protein 645	27697	0.24
chr2_181056389_181056548	0.16	CWC22	CWC22 spliceosome-associated protein homolog (S. cerevisiae)	184628	0.03
chr4_123795073_123795451	0.16	RP11-170N16.3		10605	0.18
chr1_98369641_98369792	0.16	DPYD	dihydropyrimidine dehydrogenase	16837	0.28
chr6_21666737_21667013	0.16	SOX4	SRY (sex determining region Y)-box 4	72804	0.14
chr7_3632163_3632314	0.16	AC011284.3		51178	0.18
chr18_57576623_57576774	0.16	PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	9450	0.26
chr6_169471024_169471293	0.16	XXyac-YX65C7_A.2		142191	0.05
chr2_222761989_222762140	0.16	EPHA4	EPH receptor A4	323142	0.01
chr15_68155525_68155920	0.16	ENSG00000206625	.	23339	0.22
chr8_2094260_2094411	0.15	MYOM2	myomesin 2	101151	0.08
chr19_11305569_11305933	0.15	KANK2	KN motif and ankyrin repeat domains 2	117	0.94
chr12_32688080_32688676	0.15	FGD4	FYVE, RhoGEF and PH domain containing 4	1120	0.61
chr2_167231853_167232143	0.15	SCN9A	sodium channel, voltage-gated, type IX, alpha subunit	499	0.84
chr13_47022181_47022332	0.15	KIAA0226L	KIAA0226-like	9931	0.22
chr10_4541408_4541559	0.15	ENSG00000207124	.	15661	0.3
chr1_183512654_183512805	0.15	NCF2	neutrophil cytosolic factor 2	25631	0.17
chr13_115030758_115030909	0.15	ENSG00000265450	.	8470	0.15
chr10_131755852_131756003	0.15	EBF3	early B-cell factor 3	6178	0.32
chr2_120189452_120190154	0.15	TMEM37	transmembrane protein 37	358	0.88
chr12_8090559_8091101	0.15	SLC2A3	solute carrier family 2 (facilitated glucose transporter), member 3	1959	0.27
chr2_240971693_240971844	0.15	OR6B2	olfactory receptor, family 6, subfamily B, member 2	1862	0.27
chr6_56573305_56573456	0.15	DST	dystonin	65586	0.13
chr5_39424296_39424549	0.15	DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	548	0.85
chr4_187901309_187901460	0.15	ENSG00000252382	.	122774	0.06
chr8_67088876_67089283	0.15	CRH	corticotropin releasing hormone	1881	0.44
chr20_47942346_47942497	0.15	ENSG00000212304	.	45201	0.1
chr8_17353947_17354148	0.15	SLC7A2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	550	0.83
chr12_13351250_13351500	0.15	EMP1	epithelial membrane protein 1	1655	0.47
chr1_120674474_120674625	0.15	ENSG00000207149	.	4987	0.29
chr3_105084192_105084343	0.15	ALCAM	activated leukocyte cell adhesion molecule	1486	0.6
chr4_169554219_169554371	0.15	PALLD	palladin, cytoskeletal associated protein	1527	0.43
chr9_13719940_13720091	0.15	MPDZ	multiple PDZ domain protein	440426	0.01
chr1_158969050_158969253	0.15	IFI16	interferon, gamma-inducible protein 16	607	0.76
chr2_198539361_198539512	0.15	RFTN2	raftlin family member 2	1283	0.45
chr17_31255277_31255844	0.15	TMEM98	transmembrane protein 98	332	0.89
chr3_112013106_112013257	0.15	SLC9C1	solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1	76	0.98
chr9_16654239_16654390	0.15	RP11-62F24.1		28640	0.21
chr17_70443074_70443225	0.15	ENSG00000200783	.	217142	0.02
chr10_44304922_44305073	0.15	ZNF32	zinc finger protein 32	160693	0.03
chr10_28967900_28968168	0.15	BAMBI	BMP and activin membrane-bound inhibitor	1763	0.35
chr18_9017410_9017607	0.15	NDUFV2	NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa	85120	0.08
chr4_74904304_74905084	0.14	CXCL3	chemokine (C-X-C motif) ligand 3	288	0.87
chr7_22603039_22603190	0.14	AC002480.3		158	0.96
chr5_158476960_158477151	0.14	EBF1	early B-cell factor 1	49646	0.14
chr16_86705742_86705893	0.14	FOXL1	forkhead box L1	93702	0.08
chr9_107731134_107731381	0.14	ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	40739	0.17
chr13_109567770_109568133	0.14	MYO16	myosin XVI	29434	0.26
chr20_52539385_52539536	0.14	AC005220.3		17239	0.25
chr12_104199013_104199284	0.14	RP11-650K20.2		14240	0.14
chr21_17569279_17569619	0.14	ENSG00000201025	.	87640	0.1
chr18_475431_475606	0.14	COLEC12	collectin sub-family member 12	25204	0.17
chr10_31353638_31353789	0.14	ENSG00000263578	.	1263	0.56
chr7_120664875_120665040	0.14	CPED1	cadherin-like and PC-esterase domain containing 1	35281	0.16
chr9_93558631_93558871	0.14	SYK	spleen tyrosine kinase	5318	0.35
chr4_109542934_109543085	0.14	RPL34	ribosomal protein L34	1197	0.48
chr12_81472525_81472676	0.14	ACSS3	acyl-CoA synthetase short-chain family member 3	764	0.72
chr4_129557030_129557181	0.14	ENSG00000238802	.	120076	0.06
chr17_13503336_13503489	0.14	HS3ST3A1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	1832	0.45
chr15_56756676_56757268	0.14	MNS1	meiosis-specific nuclear structural 1	363	0.92
chr5_92333922_92334106	0.14	ENSG00000221810	.	280794	0.01
chr18_66499529_66499680	0.14	CCDC102B	coiled-coil domain containing 102B	4397	0.25
chr2_134325837_134326056	0.14	NCKAP5	NCK-associated protein 5	85	0.98
chr15_28423630_28423781	0.14	HERC2	HECT and RLD domain containing E3 ubiquitin protein ligase 2	4136	0.31
chr5_74634021_74634424	0.14	HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase	264	0.89
chr4_81188224_81188744	0.14	FGF5	fibroblast growth factor 5	691	0.76
chr8_97468793_97469144	0.14	ENSG00000202095	.	25580	0.2
chr1_246750885_246751091	0.14	RP11-439E19.1		18187	0.16
chr18_60774564_60774715	0.14	RP11-299P2.1		43914	0.17
chr7_66532196_66532424	0.13	ENSG00000266525	.	47074	0.12
chr13_111856007_111856158	0.13	ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	667	0.76
chr16_73091234_73091750	0.13	ZFHX3	zinc finger homeobox 3	2105	0.37
chr11_16813436_16813790	0.13	PLEKHA7	pleckstrin homology domain containing, family A member 7	20417	0.2
chr7_150485274_150485425	0.13	TMEM176B	transmembrane protein 176B	8471	0.16
chr1_183791724_183791999	0.13	RGL1	ral guanine nucleotide dissociation stimulator-like 1	17571	0.24
chr7_136831692_136831856	0.13	hsa-mir-490	hsa-mir-490	17243	0.28
chr4_177711668_177712016	0.13	VEGFC	vascular endothelial growth factor C	2039	0.48
chr6_150177526_150177677	0.13	RP11-350J20.12		4003	0.14
chr18_28681249_28681463	0.13	RP11-408H20.2		195	0.81
chr16_65152808_65153250	0.13	CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	2804	0.44
chr8_116850745_116850896	0.13	TRPS1	trichorhinophalangeal syndrome I	28921	0.26
chr19_10927638_10927909	0.13	ENSG00000207752	.	399	0.76
chr4_189897651_189897802	0.13	ENSG00000252275	.	259847	0.02
chr3_81873946_81874241	0.13	GBE1	glucan (1,4-alpha-), branching enzyme 1	62781	0.16
chr3_151976533_151976804	0.13	MBNL1	muscleblind-like splicing regulator 1	9161	0.23
chr5_39547598_39547749	0.13	DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	85271	0.11
chr8_136478593_136478847	0.13	KHDRBS3	KH domain containing, RNA binding, signal transduction associated 3	7770	0.25
chr19_57888956_57889107	0.13	ZNF547	zinc finger protein 547	6034	0.08
chr1_215179577_215179737	0.13	KCNK2	potassium channel, subfamily K, member 2	459	0.91
chr7_143581670_143581927	0.13	FAM115A	family with sequence similarity 115, member A	665	0.7
chr3_167811230_167811432	0.13	GOLIM4	golgi integral membrane protein 4	1801	0.51
chr2_170428489_170428760	0.13	FASTKD1	FAST kinase domains 1	875	0.59
chr12_115250983_115251152	0.13	ENSG00000252459	.	75558	0.12
chr12_95084083_95084234	0.13	TMCC3	transmembrane and coiled-coil domain family 3	39820	0.19
chr12_94132814_94133007	0.13	RP11-887P2.5		1311	0.51
chr13_110496874_110497025	0.13	IRS2	insulin receptor substrate 2	58034	0.14
chrX_109663875_109664026	0.13	RGAG1	retrotransposon gag domain containing 1	1665	0.42
chr12_64239539_64239880	0.13	SRGAP1	SLIT-ROBO Rho GTPase activating protein 1	1168	0.42
chr2_145276293_145276624	0.13	ZEB2-AS1	ZEB2 antisense RNA 1	434	0.52
chr7_72570751_72570902	0.12	AC006995.8		45341	0.1
chr8_4093405_4093556	0.12	ENSG00000264588	.	156864	0.04
chr4_186388513_186388728	0.12	RP11-279O9.4	Uncharacterized protein	4050	0.16
chr7_95239102_95239253	0.12	AC002451.3		69	0.98
chr4_97329089_97329304	0.12	ENSG00000201640	.	59007	0.17
chr9_91608315_91608498	0.12	S1PR3	sphingosine-1-phosphate receptor 3	2044	0.31

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXF2_FOXJ1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.1	0.2	GO:0001880	Mullerian duct regression(GO:0001880)
0.1	0.2	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:0030210	heparin biosynthetic process(GO:0030210)
0.0	0.1	GO:0060013	righting reflex(GO:0060013)
0.0	0.2	GO:0008354	germ cell migration(GO:0008354)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0032236	obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0	0.1	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.1	GO:0071694	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.0	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.1	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0	0.1	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.2	GO:0031641	regulation of myelination(GO:0031641)
0.0	0.1	GO:0033004	negative regulation of mast cell activation(GO:0033004)
0.0	0.1	GO:0008049	male courtship behavior(GO:0008049)
0.0	0.1	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.1	GO:0051549	regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0	0.1	GO:0060753	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0	0.1	GO:0015802	basic amino acid transport(GO:0015802)
0.0	0.0	GO:1901798	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0	0.1	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.0	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.1	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.0	GO:0032632	interleukin-3 production(GO:0032632)
0.0	0.1	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.1	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.1	GO:0000019	regulation of mitotic recombination(GO:0000019)
0.0	0.1	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.0	0.1	GO:0035929	steroid hormone secretion(GO:0035929)
0.0	0.0	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.0	0.1	GO:0090399	replicative senescence(GO:0090399)
0.0	0.0	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.3	GO:0098743	cartilage condensation(GO:0001502) cell aggregation(GO:0098743)
0.0	0.0	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.1	GO:0019934	cGMP-mediated signaling(GO:0019934)
0.0	0.2	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
0.0	0.0	GO:0071801	regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0	0.0	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.4	GO:0050771	negative regulation of axonogenesis(GO:0050771)
0.0	0.0	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.0	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.1	GO:0002634	regulation of germinal center formation(GO:0002634)
0.0	0.0	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.1	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.1	GO:0009249	protein lipoylation(GO:0009249)
0.0	0.1	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.0	GO:0048669	collateral sprouting in absence of injury(GO:0048669)
0.0	0.1	GO:0000089	mitotic metaphase(GO:0000089)
0.0	0.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.0	GO:0090266	positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.0	0.0	GO:0033008	positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of leukocyte degranulation(GO:0043302) positive regulation of mast cell degranulation(GO:0043306)
0.0	0.0	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.0	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.0	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.0	GO:0014041	regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0	0.0	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.0	GO:0060033	anatomical structure regression(GO:0060033)
0.0	0.0	GO:0042637	catagen(GO:0042637)
0.0	0.0	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.0	GO:0051138	NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0	0.0	GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0	0.1	GO:0009200	deoxyribonucleoside triphosphate metabolic process(GO:0009200)
0.0	0.0	GO:0007571	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.0	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0	0.0	GO:0002138	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0	0.0	GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.1	0.2	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.3	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.2	GO:0016342	catenin complex(GO:0016342)
0.0	0.1	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.1	GO:0030870	Mre11 complex(GO:0030870)
0.0	0.1	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.0	0.0	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.1	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.0	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.4	GO:0030175	filopodium(GO:0030175)
0.0	0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.0	GO:0005787	signal peptidase complex(GO:0005787)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.1	0.2	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0	0.3	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.3	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.2	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.1	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.1	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.1	GO:0016933	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0	0.1	GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	0.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.1	GO:0052659	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.1	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.0	0.5	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.0	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.1	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.1	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.1	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.1	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.0	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.0	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.0	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.0	GO:0016728	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.0	GO:0035198	miRNA binding(GO:0035198)
0.0	0.1	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.0	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.1	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.0	GO:0032356	single guanine insertion binding(GO:0032142) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357)
0.0	0.1	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.0	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.2	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	0.2	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	0.1	GO:0051018	protein kinase A binding(GO:0051018)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.2	PID ALK2 PATHWAY	ALK2 signaling events
0.0	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.0	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.0	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.4	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.5	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.7	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.2	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.2	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.0	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events