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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for FOXF2_FOXJ1

Z-value: 0.84

Motif logo

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Transcription factors associated with FOXF2_FOXJ1

Gene Symbol Gene ID Gene Info
FOXF2
ENSG00000137273.3 forkhead box F2
FOXJ1
ENSG00000129654.7 forkhead box J1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr6_1393770_1393965FOXF237980.264951-0.521.6e-01Click!
chr6_1389874_1390147FOXF2590.9785860.363.4e-01Click!
chr6_1391347_1391718FOXF214630.4537430.294.5e-01Click!
chr6_1392834_1392985FOXF228400.298522-0.274.8e-01Click!
chr6_1407500_1407651FOXF2175060.2099360.274.9e-01Click!
chr17_74137094_74137375FOXJ11460.736402-0.373.3e-01Click!

Activity of the FOXF2_FOXJ1 motif across conditions

Conditions sorted by the z-value of the FOXF2_FOXJ1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr9_120466546_120467060 0.49 TLR4
 toll-like receptor 4
 153
 0.96
chr8_15398472_15398721 0.49 TUSC3
 tumor suppressor candidate 3
 804
 0.72
chr4_71587677_71588145 0.44 RUFY3
 RUN and FYVE domain containing 3
 183
 0.92
chr8_107738861_107739281 0.35 OXR1
 oxidation resistance 1
 658
 0.71
chr1_109913452_109914259 0.34 SORT1
 sortilin 1
 22124
 0.14
chr5_59893443_59893927 0.34 DEPDC1B
 DEP domain containing 1B
 102276
 0.07
chr7_19152184_19152434 0.34 AC003986.6
212
 0.92
chr2_152214605_152215087 0.33 TNFAIP6
 tumor necrosis factor, alpha-induced protein 6
 740
 0.63
chr10_13569706_13570278 0.32 RP11-214D15.2
524
 0.45
chr7_79449658_79449850 0.32 ENSG00000206818
 .
 91770
 0.09
chr2_27995563_27995714 0.30 MRPL33
 mitochondrial ribosomal protein L33
 1054
 0.48
chr6_151648337_151648657 0.30 AKAP12
 A kinase (PRKA) anchor protein 12
 1674
 0.27
chr9_128235766_128235975 0.30 MAPKAP1
 mitogen-activated protein kinase associated protein 1
 10910
 0.23
chr6_44510355_44510599 0.29 ENSG00000266619
 .
 107099
 0.06
chr1_216773992_216774229 0.28 ESRRG
 estrogen-related receptor gamma
 122564
 0.06
chr4_115282272_115282768 0.28 UGT8
 UDP glycosyltransferase 8
 237091
 0.02
chr6_132268442_132268593 0.28 RP11-69I8.3
3569
 0.25
chr6_136223158_136223344 0.27 ENSG00000238921
 .
 12642
 0.24
chr6_153269357_153269511 0.27 FBXO5
 F-box protein 5
 34719
 0.14
chr8_48571824_48572102 0.27 SPIDR
 scaffolding protein involved in DNA repair
 263
 0.93
chr3_59803963_59804385 0.27 NPCDR1
 nasopharyngeal carcinoma, down-regulated 1
 153409
 0.05
chr7_19308580_19308778 0.25 FERD3L
 Fer3-like bHLH transcription factor
 123635
 0.05
chr14_79747812_79748200 0.25 NRXN3
 neurexin 3
 1757
 0.44
chr13_37493387_37493814 0.25 SMAD9
 SMAD family member 9
 775
 0.69
chr18_25756118_25756718 0.24 CDH2
 cadherin 2, type 1, N-cadherin (neuronal)
 992
 0.73
chr11_36616853_36617082 0.24 C11orf74
 chromosome 11 open reading frame 74
 567
 0.5
chr19_54534469_54534642 0.24 VSTM1
 V-set and transmembrane domain containing 1
 27122
 0.08
chr14_52707563_52708006 0.24 PTGDR
 prostaglandin D2 receptor (DP)
 26647
 0.22
chr18_65983753_65984295 0.24 TMX3
 thioredoxin-related transmembrane protein 3
 398270
 0.01
chr1_172110530_172111247 0.23 ENSG00000207949
 .
 2841
 0.22
chr10_45473981_45474319 0.23 C10orf10
 chromosome 10 open reading frame 10
 87
 0.95
chr12_21981553_21981788 0.23 RP11-729I10.2
1526
 0.43
chr9_75486718_75486907 0.23 ALDH1A1
 aldehyde dehydrogenase 1 family, member A1
 81159
 0.11
chr1_60031328_60031726 0.22 FGGY
 FGGY carbohydrate kinase domain containing
 11937
 0.3
chr5_90515283_90515434 0.22 ENSG00000199643
 .
 51186
 0.18
chr21_17442999_17443232 0.22 ENSG00000252273
 .
 35286
 0.24
chr12_19392736_19392931 0.22 PLEKHA5
 pleckstrin homology domain containing, family A member 5
 2975
 0.32
chr7_148232370_148232768 0.22 C7orf33
 chromosome 7 open reading frame 33
 55088
 0.14
chr13_33803329_33803516 0.22 STARD13
 StAR-related lipid transfer (START) domain containing 13
 23279
 0.2
chr2_45200338_45200489 0.21 SIX3-AS1
 SIX3 antisense RNA 1
 31401
 0.17
chr10_49734527_49734828 0.21 ARHGAP22
 Rho GTPase activating protein 22
 2396
 0.33
chr3_87039220_87039752 0.21 VGLL3
 vestigial like 3 (Drosophila)
 366
 0.93
chr16_88628658_88628817 0.21 ZC3H18
 zinc finger CCCH-type containing 18
 8052
 0.16
chr3_190530283_190530682 0.21 GMNC
 geminin coiled-coil domain containing
 49922
 0.18
chr2_185461919_185462338 0.21 ZNF804A
 zinc finger protein 804A
 965
 0.73
chr12_1583558_1583788 0.21 WNT5B
 wingless-type MMTV integration site family, member 5B
 55384
 0.12
chr1_182931948_182932121 0.20 ENSG00000264768
 .
 3324
 0.2
chr14_59215785_59216332 0.20 ENSG00000221427
 .
 21906
 0.26
chr3_18153147_18153551 0.20 RP11-158G18.1
297778
 0.01
chr22_36367515_36367713 0.20 RBFOX2
 RNA binding protein, fox-1 homolog (C. elegans) 2
 9900
 0.29
chr16_25047588_25047739 0.20 ARHGAP17
 Rho GTPase activating protein 17
 20676
 0.23
chr5_141980216_141980760 0.20 AC005592.2
19075
 0.18
chr2_74104795_74104946 0.20 ACTG2
 actin, gamma 2, smooth muscle, enteric
 15224
 0.17
chr15_61044545_61044696 0.20 RP11-554D20.1
11485
 0.22
chr8_38855409_38855789 0.19 ADAM9
 ADAM metallopeptidase domain 9
 1094
 0.34
chr7_27217405_27217623 0.19 RP1-170O19.20
 Uncharacterized protein
 2118
 0.1
chr15_99864758_99865035 0.19 AC022819.2
 Uncharacterized protein
 5068
 0.23
chr2_38008128_38008279 0.19 CDC42EP3
 CDC42 effector protein (Rho GTPase binding) 3
 42592
 0.19
chr5_131893791_131893942 0.19 RAD50
 RAD50 homolog (S. cerevisiae)
 943
 0.42
chr12_15038397_15038786 0.19 MGP
 matrix Gla protein
 200
 0.92
chr15_85590935_85591086 0.19 PDE8A
 phosphodiesterase 8A
 65798
 0.1
chr10_126843486_126843769 0.18 CTBP2
 C-terminal binding protein 2
 3658
 0.35
chr8_48297219_48297488 0.18 SPIDR
 scaffolding protein involved in DNA repair
 55610
 0.16
chr18_52990549_52990700 0.18 TCF4
 transcription factor 4
 1099
 0.65
chr13_31481253_31481536 0.18 MEDAG
 mesenteric estrogen-dependent adipogenesis
 551
 0.78
chr21_17584209_17584483 0.18 ENSG00000201025
 .
 72743
 0.13
chr2_176992012_176992333 0.18 HOXD8
 homeobox D8
 2250
 0.12
chr10_134389068_134389378 0.18 INPP5A
 inositol polyphosphate-5-phosphatase, 40kDa
 32207
 0.18
chr1_198859885_198860036 0.18 ENSG00000207759
 .
 31678
 0.2
chr3_119921742_119921893 0.18 ENSG00000206721
 .
 7350
 0.22
chr20_9048816_9049419 0.18 PLCB4
 phospholipase C, beta 4
 293
 0.9
chr7_127293840_127294146 0.18 SND1
 staphylococcal nuclease and tudor domain containing 1
 1759
 0.28
chr21_28337250_28337401 0.18 ADAMTS5
 ADAM metallopeptidase with thrombospondin type 1 motif, 5
 1507
 0.46
chr5_123493061_123493232 0.18 CSNK1G3
 casein kinase 1, gamma 3
 569027
 0.0
chr2_146281977_146282128 0.17 ENSG00000253036
 .
 189414
 0.03
chr1_65730855_65731313 0.17 DNAJC6
 DnaJ (Hsp40) homolog, subfamily C, member 6
 647
 0.77
chr2_63971666_63971817 0.17 ENSG00000221085
 .
 49072
 0.16
chr3_114477226_114477377 0.17 ZBTB20
 zinc finger and BTB domain containing 20
 486
 0.86
chr20_1103594_1103745 0.17 PSMF1
 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
 4389
 0.25
chr2_43406321_43406536 0.17 ZFP36L2
 ZFP36 ring finger protein-like 2
 47320
 0.15
chr3_186539235_186539386 0.17 RP11-573D15.3
13829
 0.08
chr22_46988879_46989444 0.17 GRAMD4
 GRAM domain containing 4
 16135
 0.21
chr5_67323714_67323865 0.17 ENSG00000223149
 .
 60516
 0.15
chr3_9389156_9389527 0.17 THUMPD3
 THUMP domain containing 3
 15185
 0.15
chr3_73769050_73769270 0.17 PDZRN3
 PDZ domain containing ring finger 3
 95069
 0.08
chr6_113970392_113970641 0.17 ENSG00000266650
 .
 46399
 0.16
chr12_30947588_30947773 0.17 CAPRIN2
 caprin family member 2
 39795
 0.19
chr11_57529774_57530544 0.17 CTNND1
 catenin (cadherin-associated protein), delta 1
 869
 0.5
chr8_42394798_42395191 0.17 SLC20A2
 solute carrier family 20 (phosphate transporter), member 2
 1203
 0.3
chr13_73712912_73713063 0.16 ENSG00000265959
 .
 14040
 0.19
chr9_110400851_110401256 0.16 ENSG00000202308
 .
 24474
 0.24
chr13_21790667_21790818 0.16 MRP63
 mitochondrial ribosomal protein 63
 39958
 0.12
chr16_67512921_67513072 0.16 ATP6V0D1
 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
 1986
 0.17
chr12_76144582_76144847 0.16 ENSG00000264062
 .
 26393
 0.22
chr3_15847185_15847355 0.16 ANKRD28
 ankyrin repeat domain 28
 9242
 0.22
chrX_22318596_22318928 0.16 ZNF645
 zinc finger protein 645
 27697
 0.24
chr2_181056389_181056548 0.16 CWC22
 CWC22 spliceosome-associated protein homolog (S. cerevisiae)
 184628
 0.03
chr4_123795073_123795451 0.16 RP11-170N16.3
10605
 0.18
chr1_98369641_98369792 0.16 DPYD
 dihydropyrimidine dehydrogenase
 16837
 0.28
chr6_21666737_21667013 0.16 SOX4
 SRY (sex determining region Y)-box 4
 72804
 0.14
chr7_3632163_3632314 0.16 AC011284.3
51178
 0.18
chr18_57576623_57576774 0.16 PMAIP1
 phorbol-12-myristate-13-acetate-induced protein 1
 9450
 0.26
chr6_169471024_169471293 0.16 XXyac-YX65C7_A.2
142191
 0.05
chr2_222761989_222762140 0.16 EPHA4
 EPH receptor A4
 323142
 0.01
chr15_68155525_68155920 0.16 ENSG00000206625
 .
 23339
 0.22
chr8_2094260_2094411 0.15 MYOM2
 myomesin 2
 101151
 0.08
chr19_11305569_11305933 0.15 KANK2
 KN motif and ankyrin repeat domains 2
 117
 0.94
chr12_32688080_32688676 0.15 FGD4
 FYVE, RhoGEF and PH domain containing 4
 1120
 0.61
chr2_167231853_167232143 0.15 SCN9A
 sodium channel, voltage-gated, type IX, alpha subunit
 499
 0.84
chr13_47022181_47022332 0.15 KIAA0226L
 KIAA0226-like
 9931
 0.22
chr10_4541408_4541559 0.15 ENSG00000207124
 .
 15661
 0.3
chr1_183512654_183512805 0.15 NCF2
 neutrophil cytosolic factor 2
 25631
 0.17
chr13_115030758_115030909 0.15 ENSG00000265450
 .
 8470
 0.15
chr10_131755852_131756003 0.15 EBF3
 early B-cell factor 3
 6178
 0.32
chr2_120189452_120190154 0.15 TMEM37
 transmembrane protein 37
 358
 0.88
chr12_8090559_8091101 0.15 SLC2A3
 solute carrier family 2 (facilitated glucose transporter), member 3
 1959
 0.27
chr2_240971693_240971844 0.15 OR6B2
 olfactory receptor, family 6, subfamily B, member 2
 1862
 0.27
chr6_56573305_56573456 0.15 DST
 dystonin
 65586
 0.13
chr5_39424296_39424549 0.15 DAB2
 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
 548
 0.85
chr4_187901309_187901460 0.15 ENSG00000252382
 .
 122774
 0.06
chr8_67088876_67089283 0.15 CRH
 corticotropin releasing hormone
 1881
 0.44
chr20_47942346_47942497 0.15 ENSG00000212304
 .
 45201
 0.1
chr8_17353947_17354148 0.15 SLC7A2
 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
 550
 0.83
chr12_13351250_13351500 0.15 EMP1
 epithelial membrane protein 1
 1655
 0.47
chr1_120674474_120674625 0.15 ENSG00000207149
 .
 4987
 0.29
chr3_105084192_105084343 0.15 ALCAM
 activated leukocyte cell adhesion molecule
 1486
 0.6
chr4_169554219_169554371 0.15 PALLD
 palladin, cytoskeletal associated protein
 1527
 0.43
chr9_13719940_13720091 0.15 MPDZ
 multiple PDZ domain protein
 440426
 0.01
chr1_158969050_158969253 0.15 IFI16
 interferon, gamma-inducible protein 16
 607
 0.76
chr2_198539361_198539512 0.15 RFTN2
 raftlin family member 2
 1283
 0.45
chr17_31255277_31255844 0.15 TMEM98
 transmembrane protein 98
 332
 0.89
chr3_112013106_112013257 0.15 SLC9C1
 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1
 76
 0.98
chr9_16654239_16654390 0.15 RP11-62F24.1
28640
 0.21
chr17_70443074_70443225 0.15 ENSG00000200783
 .
 217142
 0.02
chr10_44304922_44305073 0.15 ZNF32
 zinc finger protein 32
 160693
 0.03
chr10_28967900_28968168 0.15 BAMBI
 BMP and activin membrane-bound inhibitor
 1763
 0.35
chr18_9017410_9017607 0.15 NDUFV2
 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
 85120
 0.08
chr4_74904304_74905084 0.14 CXCL3
 chemokine (C-X-C motif) ligand 3
 288
 0.87
chr7_22603039_22603190 0.14 AC002480.3
158
 0.96
chr5_158476960_158477151 0.14 EBF1
 early B-cell factor 1
 49646
 0.14
chr16_86705742_86705893 0.14 FOXL1
 forkhead box L1
 93702
 0.08
chr9_107731134_107731381 0.14 ABCA1
 ATP-binding cassette, sub-family A (ABC1), member 1
 40739
 0.17
chr13_109567770_109568133 0.14 MYO16
 myosin XVI
 29434
 0.26
chr20_52539385_52539536 0.14 AC005220.3
17239
 0.25
chr12_104199013_104199284 0.14 RP11-650K20.2
14240
 0.14
chr21_17569279_17569619 0.14 ENSG00000201025
 .
 87640
 0.1
chr18_475431_475606 0.14 COLEC12
 collectin sub-family member 12
 25204
 0.17
chr10_31353638_31353789 0.14 ENSG00000263578
 .
 1263
 0.56
chr7_120664875_120665040 0.14 CPED1
 cadherin-like and PC-esterase domain containing 1
 35281
 0.16
chr9_93558631_93558871 0.14 SYK
 spleen tyrosine kinase
 5318
 0.35
chr4_109542934_109543085 0.14 RPL34
 ribosomal protein L34
 1197
 0.48
chr12_81472525_81472676 0.14 ACSS3
 acyl-CoA synthetase short-chain family member 3
 764
 0.72
chr4_129557030_129557181 0.14 ENSG00000238802
 .
 120076
 0.06
chr17_13503336_13503489 0.14 HS3ST3A1
 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
 1832
 0.45
chr15_56756676_56757268 0.14 MNS1
 meiosis-specific nuclear structural 1
 363
 0.92
chr5_92333922_92334106 0.14 ENSG00000221810
 .
 280794
 0.01
chr18_66499529_66499680 0.14 CCDC102B
 coiled-coil domain containing 102B
 4397
 0.25
chr2_134325837_134326056 0.14 NCKAP5
 NCK-associated protein 5
 85
 0.98
chr15_28423630_28423781 0.14 HERC2
 HECT and RLD domain containing E3 ubiquitin protein ligase 2
 4136
 0.31
chr5_74634021_74634424 0.14 HMGCR
 3-hydroxy-3-methylglutaryl-CoA reductase
 264
 0.89
chr4_81188224_81188744 0.14 FGF5
 fibroblast growth factor 5
 691
 0.76
chr8_97468793_97469144 0.14 ENSG00000202095
 .
 25580
 0.2
chr1_246750885_246751091 0.14 RP11-439E19.1
18187
 0.16
chr18_60774564_60774715 0.14 RP11-299P2.1
43914
 0.17
chr7_66532196_66532424 0.13 ENSG00000266525
 .
 47074
 0.12
chr13_111856007_111856158 0.13 ARHGEF7
 Rho guanine nucleotide exchange factor (GEF) 7
 667
 0.76
chr16_73091234_73091750 0.13 ZFHX3
 zinc finger homeobox 3
 2105
 0.37
chr11_16813436_16813790 0.13 PLEKHA7
 pleckstrin homology domain containing, family A member 7
 20417
 0.2
chr7_150485274_150485425 0.13 TMEM176B
 transmembrane protein 176B
 8471
 0.16
chr1_183791724_183791999 0.13 RGL1
 ral guanine nucleotide dissociation stimulator-like 1
 17571
 0.24
chr7_136831692_136831856 0.13 hsa-mir-490
 hsa-mir-490
 17243
 0.28
chr4_177711668_177712016 0.13 VEGFC
 vascular endothelial growth factor C
 2039
 0.48
chr6_150177526_150177677 0.13 RP11-350J20.12
4003
 0.14
chr18_28681249_28681463 0.13 RP11-408H20.2
195
 0.81
chr16_65152808_65153250 0.13 CDH11
 cadherin 11, type 2, OB-cadherin (osteoblast)
 2804
 0.44
chr8_116850745_116850896 0.13 TRPS1
 trichorhinophalangeal syndrome I
 28921
 0.26
chr19_10927638_10927909 0.13 ENSG00000207752
 .
 399
 0.76
chr4_189897651_189897802 0.13 ENSG00000252275
 .
 259847
 0.02
chr3_81873946_81874241 0.13 GBE1
 glucan (1,4-alpha-), branching enzyme 1
 62781
 0.16
chr3_151976533_151976804 0.13 MBNL1
 muscleblind-like splicing regulator 1
 9161
 0.23
chr5_39547598_39547749 0.13 DAB2
 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
 85271
 0.11
chr8_136478593_136478847 0.13 KHDRBS3
 KH domain containing, RNA binding, signal transduction associated 3
 7770
 0.25
chr19_57888956_57889107 0.13 ZNF547
 zinc finger protein 547
 6034
 0.08
chr1_215179577_215179737 0.13 KCNK2
 potassium channel, subfamily K, member 2
 459
 0.91
chr7_143581670_143581927 0.13 FAM115A
 family with sequence similarity 115, member A
 665
 0.7
chr3_167811230_167811432 0.13 GOLIM4
 golgi integral membrane protein 4
 1801
 0.51
chr2_170428489_170428760 0.13 FASTKD1
 FAST kinase domains 1
 875
 0.59
chr12_115250983_115251152 0.13 ENSG00000252459
 .
 75558
 0.12
chr12_95084083_95084234 0.13 TMCC3
 transmembrane and coiled-coil domain family 3
 39820
 0.19
chr12_94132814_94133007 0.13 RP11-887P2.5
1311
 0.51
chr13_110496874_110497025 0.13 IRS2
 insulin receptor substrate 2
 58034
 0.14
chrX_109663875_109664026 0.13 RGAG1
 retrotransposon gag domain containing 1
 1665
 0.42
chr12_64239539_64239880 0.13 SRGAP1
 SLIT-ROBO Rho GTPase activating protein 1
 1168
 0.42
chr2_145276293_145276624 0.13 ZEB2-AS1
 ZEB2 antisense RNA 1
 434
 0.52
chr7_72570751_72570902 0.12 AC006995.8
45341
 0.1
chr8_4093405_4093556 0.12 ENSG00000264588
 .
 156864
 0.04
chr4_186388513_186388728 0.12 RP11-279O9.4
 Uncharacterized protein
 4050
 0.16
chr7_95239102_95239253 0.12 AC002451.3
69
 0.98
chr4_97329089_97329304 0.12 ENSG00000201640
 .
 59007
 0.17
chr9_91608315_91608498 0.12 S1PR3
 sphingosine-1-phosphate receptor 3
 2044
 0.31

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXF2_FOXJ1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.1 0.2 GO:0001880 Mullerian duct regression(GO:0001880)
0.1 0.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0030210 heparin biosynthetic process(GO:0030210)
0.0 0.1 GO:0060013 righting reflex(GO:0060013)
0.0 0.2 GO:0008354 germ cell migration(GO:0008354)
0.0 0.1 GO:0051451 myoblast migration(GO:0051451)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.1 GO:0032236 obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0 0.1 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.1 GO:0071694 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.0 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.1 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.1 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.2 GO:0031641 regulation of myelination(GO:0031641)
0.0 0.1 GO:0033004 negative regulation of mast cell activation(GO:0033004)
0.0 0.1 GO:0008049 male courtship behavior(GO:0008049)
0.0 0.1 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.1 GO:0051549 regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0 0.1 GO:0060753 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.1 GO:0015802 basic amino acid transport(GO:0015802)
0.0 0.0 GO:1901798 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0 0.1 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.0 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.1 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 0.0 GO:0032632 interleukin-3 production(GO:0032632)
0.0 0.1 GO:0002689 negative regulation of leukocyte chemotaxis(GO:0002689)
0.0 0.1 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.1 GO:0000019 regulation of mitotic recombination(GO:0000019)
0.0 0.1 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.1 GO:0035929 steroid hormone secretion(GO:0035929)
0.0 0.0 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.0 0.1 GO:0090399 replicative senescence(GO:0090399)
0.0 0.0 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.3 GO:0098743 cartilage condensation(GO:0001502) cell aggregation(GO:0098743)
0.0 0.0 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.0 0.1 GO:0019934 cGMP-mediated signaling(GO:0019934)
0.0 0.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.0 GO:0071801 regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0 0.0 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.4 GO:0050771 negative regulation of axonogenesis(GO:0050771)
0.0 0.0 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.0 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 0.1 GO:0002634 regulation of germinal center formation(GO:0002634)
0.0 0.0 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.1 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.1 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.1 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.0 GO:0048669 collateral sprouting in absence of injury(GO:0048669)
0.0 0.1 GO:0000089 mitotic metaphase(GO:0000089)
0.0 0.0 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.0 GO:0090266 positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.0 GO:0033008 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of leukocyte degranulation(GO:0043302) positive regulation of mast cell degranulation(GO:0043306)
0.0 0.0 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.0 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.0 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.0 GO:0014041 regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0 0.0 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.0 GO:0060033 anatomical structure regression(GO:0060033)
0.0 0.0 GO:0042637 catagen(GO:0042637)
0.0 0.0 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0 0.0 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.0 GO:0051138 NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0 0.0 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0 0.1 GO:0009200 deoxyribonucleoside triphosphate metabolic process(GO:0009200)
0.0 0.0 GO:0007571 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0 0.0 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0 0.0 GO:0002138 retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0 0.0 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.2 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.0 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.2 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.1 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.0 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.1 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.0 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.0 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.4 GO:0030175 filopodium(GO:0030175)
0.0 0.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.0 GO:0005787 signal peptidase complex(GO:0005787)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.1 0.2 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.3 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.0 0.3 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.2 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.1 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.1 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.1 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.1 GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0 0.1 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.1 GO:0052659 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0 0.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.1 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.0 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.1 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.0 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.0 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.0 0.0 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.0 GO:0035198 miRNA binding(GO:0035198)
0.0 0.1 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.0 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0 0.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.0 GO:0032356 single guanine insertion binding(GO:0032142) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357)
0.0 0.1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.0 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0051018 protein kinase A binding(GO:0051018)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.2 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.0 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.0 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 0.0 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.0 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.1 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.7 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.2 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.2 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.0 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events