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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for GLIS1

Z-value: 0.16

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Transcription factors associated with GLIS1

Gene Symbol Gene ID Gene Info
ENSG00000174332.3 GLIS1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
GLIS1chr1_54205372_5420553255750.204329-0.694.1e-02Click!
GLIS1chr1_54203045_5420319632430.245145-0.599.7e-02Click!
GLIS1chr1_54202397_5420254825950.275475-0.541.3e-01Click!
GLIS1chr1_54205007_5420536253070.206770-0.541.3e-01Click!
GLIS1chr1_54195063_5419521447390.217334-0.442.4e-01Click!

Activity of the GLIS1 motif across conditions

Conditions sorted by the z-value of the GLIS1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr18_11751659_11751810 0.08 GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
227
0.94
chr11_1593572_1594262 0.08 KRTAP5-AS1
KRTAP5-1/KRTAP5-2 antisense RNA 1
54
0.92
chr18_60825688_60825839 0.06 RP11-299P2.1

7210
0.25
chr1_118156630_118156781 0.06 FAM46C
family with sequence similarity 46, member C
8149
0.22
chr7_151119334_151119485 0.06 RP4-555L14.4

5360
0.12
chr4_185185188_185185495 0.06 ENSG00000221523
.
3243
0.26
chr12_58290122_58290785 0.05 XRCC6BP1
XRCC6 binding protein 1
44907
0.08
chr10_103539328_103539744 0.05 NPM3
nucleophosmin/nucleoplasmin 3
3634
0.18
chr19_7599221_7599435 0.03 PNPLA6
patatin-like phospholipase domain containing 6
75
0.94
chr8_29120281_29120556 0.02 KIF13B
kinesin family member 13B
172
0.94
chr5_150520697_150520848 0.02 ANXA6
annexin A6
429
0.85
chr16_58059170_58059939 0.02 MMP15
matrix metallopeptidase 15 (membrane-inserted)
84
0.96
chr11_45201780_45202121 0.02 PRDM11
PR domain containing 11
1478
0.49
chr17_80655275_80656143 0.02 RAB40B
RAB40B, member RAS oncogene family
829
0.47
chr8_11627244_11627926 0.01 NEIL2
nei endonuclease VIII-like 2 (E. coli)
337
0.84
chr14_105668576_105668727 0.01 BRF1
BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
20231
0.14
chr15_43881579_43882371 0.01 PPIP5K1
diphosphoinositol pentakisphosphate kinase 1
165
0.91
chr7_56183478_56183932 0.01 NUPR1L
nuclear protein, transcriptional regulator, 1-like
388
0.78
chr1_59250006_59250701 0.01 JUN
jun proto-oncogene
568
0.79
chr7_73498327_73498772 0.01 LIMK1
LIM domain kinase 1
279
0.91
chr4_107237686_107238085 0.01 TBCK
TBC1 domain containing kinase
24
0.75
chr1_45986537_45987565 0.01 PRDX1
peroxiredoxin 1
475
0.74
chr19_1274680_1275381 0.01 C19orf24
chromosome 19 open reading frame 24
4
0.94
chr9_136580274_136580425 0.01 SARDH
sarcosine dehydrogenase
11526
0.2
chr2_113033235_113033667 0.01 ZC3H6
zinc finger CCCH-type containing 6
273
0.91
chr11_68671451_68672010 0.01 IGHMBP2
immunoglobulin mu binding protein 2
365
0.53
chrX_40027620_40027771 0.01 BCOR
BCL6 corepressor
8878
0.31
chr1_236958581_236959780 0.01 MTR
5-methyltetrahydrofolate-homocysteine methyltransferase
198
0.96
chr2_101197927_101198078 0.01 ENSG00000238328
.
4071
0.2
chr5_98109571_98109848 0.01 RGMB
repulsive guidance molecule family member b
370
0.62
chr20_25565265_25566139 0.01 NINL
ninein-like
451
0.81
chr16_1030392_1030543 0.01 AC009041.2

785
0.33
chr18_73132_73519 0.01 RP11-683L23.1
Tubulin beta-8 chain-like protein LOC260334
23085
0.21
chr6_24495335_24495996 0.01 ALDH5A1
aldehyde dehydrogenase 5 family, member A1
468
0.82
chr8_103751111_103751305 0.01 ENSG00000266799
.
5261
0.26
chr8_145027093_145027557 0.01 PLEC
plectin
763
0.48
chr19_55684291_55685412 0.01 SYT5
synaptotagmin V
1083
0.28
chr15_43981291_43982067 0.01 CKMT1A
creatine kinase, mitochondrial 1A
3405
0.12
chr3_127319190_127319523 0.01 MCM2
minichromosome maintenance complex component 2
1411
0.36
chr12_122467875_122468026 0.00 BCL7A
B-cell CLL/lymphoma 7A
8158
0.22
chr3_50263691_50263973 0.00 GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
108
0.94
chr1_241802726_241802968 0.00 OPN3
opsin 3
816
0.6
chr16_2739999_2740150 0.00 KCTD5
potassium channel tetramerization domain containing 5
7533
0.1
chr14_102783547_102783968 0.00 ZNF839
zinc finger protein 839
43
0.97
chr9_141044575_141045102 0.00 TUBBP5
tubulin, beta pseudogene 5
24659
0.23
chr10_74020790_74021082 0.00 DDIT4
DNA-damage-inducible transcript 4
12742
0.14
chr1_226111176_226111965 0.00 PYCR2
pyrroline-5-carboxylate reductase family, member 2
389
0.46
chr13_26761202_26761553 0.00 RNF6
ring finger protein (C3H2C3 type) 6
34463
0.2
chr19_44488058_44488547 0.00 ZNF155
zinc finger protein 155
41
0.95
chr13_95247882_95248356 0.00 TGDS
TDP-glucose 4,6-dehydratase
392
0.86
chr7_27225817_27225968 0.00 HOXA11-AS
HOXA11 antisense RNA
739
0.31
chr15_84033783_84034563 0.00 BNC1
basonuclin 1
80707
0.09
chr14_37116502_37116669 0.00 PAX9
paired box 9
10188
0.18
chr10_119610_120346 0.00 TUBB8
tubulin, beta 8 class VIII
24474
0.22
chr1_8763422_8763924 0.00 RERE
arginine-glutamic acid dipeptide (RE) repeats
395
0.9
chr12_26348226_26348487 0.00 SSPN
sarcospan
73
0.98
chr2_54198319_54198701 0.00 ACYP2
acylphosphatase 2, muscle type
265
0.72
chr11_61159610_61160825 0.00 TMEM216
transmembrane protein 216
352
0.79
chr14_89884489_89884712 0.00 FOXN3-AS1
FOXN3 antisense RNA 1
902
0.43
chr17_36908995_36909604 0.00 PSMB3
proteasome (prosome, macropain) subunit, beta type, 3
299
0.72
chr20_48838007_48838158 0.00 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
30706
0.18
chr12_111843881_111845308 0.00 SH2B3
SH2B adaptor protein 3
842
0.62
chr17_5388900_5389438 0.00 DERL2
derlin 2
313
0.57
chr3_177017776_177017927 0.00 TBL1XR1
transducin (beta)-like 1 X-linked receptor 1
102590
0.08
chr19_48896929_48897565 0.00 GRIN2D
glutamate receptor, ionotropic, N-methyl D-aspartate 2D
885
0.4

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of GLIS1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)