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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for GTF2I

Z-value: 0.49

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Transcription factors associated with GTF2I

Gene Symbol Gene ID Gene Info
GTF2I
ENSG00000077809.8 GTF2I

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
GTF2Ichr7_74042267_74042418296690.1734570.835.3e-03Click!
GTF2Ichr7_74077316_7407746750340.2517430.781.3e-02Click!
GTF2Ichr7_74087036_74087187118800.2169770.665.4e-02Click!
GTF2Ichr7_74075100_7407545029180.3054880.636.6e-02Click!
GTF2Ichr7_74074778_7407495525090.3304870.472.1e-01Click!

Activity of the GTF2I motif across conditions

Conditions sorted by the z-value of the GTF2I motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr16_57654561_57654712 0.29 GPR56
 G protein-coupled receptor 56
 70
 0.96
chr12_54367495_54368083 0.25 HOXC11
 homeobox C11
 877
 0.24
chr19_17905710_17906188 0.23 B3GNT3
 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
 4
 0.96
chr11_469322_469620 0.23 RP13-317D12.3
5572
 0.1
chr17_27482435_27482735 0.22 RP11-321A17.4
15084
 0.15
chr18_74798828_74799607 0.21 MBP
 myelin basic protein
 18000
 0.27
chr3_184286801_184287672 0.21 EPHB3
 EPH receptor B3
 7664
 0.2
chr21_32715523_32716836 0.20 TIAM1
 T-cell lymphoma invasion and metastasis 1
 415
 0.91
chr1_200864498_200864649 0.20 C1orf106
 chromosome 1 open reading frame 106
 624
 0.71
chr12_54378940_54379308 0.18 HOXC10
 homeobox C10
 154
 0.46
chr16_29818645_29819422 0.17 AC009133.15
20
 0.51
chr11_116564591_116564742 0.17 BUD13
 BUD13 homolog (S. cerevisiae)
 79037
 0.07
chr19_54984842_54985004 0.17 CDC42EP5
 CDC42 effector protein (Rho GTPase binding) 5
 512
 0.62
chrX_144509559_144509857 0.17 SPANXN1
 SPANX family, member N1
 181360
 0.03
chr10_134513988_134514364 0.16 INPP5A
 inositol polyphosphate-5-phosphatase, 40kDa
 65152
 0.12
chr22_46546744_46547896 0.16 PPARA
 peroxisome proliferator-activated receptor alpha
 467
 0.75
chr12_85673938_85674715 0.16 ALX1
 ALX homeobox 1
 441
 0.91
chr2_110872434_110873339 0.15 MALL
 mal, T-cell differentiation protein-like
 713
 0.63
chr12_113905433_113905704 0.15 RP11-82C23.2
4240
 0.19
chr1_211688650_211688892 0.15 RD3
 retinal degeneration 3
 22512
 0.2
chr11_125462781_125463791 0.15 STT3A
 STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
 222
 0.82
chr22_45898330_45898748 0.14 FBLN1
 fibulin 1
 173
 0.96
chr16_51185618_51185964 0.14 SALL1
 spalt-like transcription factor 1
 605
 0.76
chr1_156093288_156093439 0.14 LMNA
 lamin A/C
 2588
 0.16
chr18_31802690_31803001 0.14 RP11-379L18.1
84
 0.8
chr4_3389662_3389979 0.14 RGS12
 regulator of G-protein signaling 12
 1759
 0.4
chr1_27924702_27924979 0.14 AHDC1
 AT hook, DNA binding motif, containing 1
 5262
 0.17
chr16_73081294_73081963 0.14 ZFHX3
 zinc finger homeobox 3
 646
 0.76
chr1_9895701_9896156 0.13 CLSTN1
 calsyntenin 1
 11344
 0.16
chr4_116124105_116124256 0.13 NDST4
 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
 89148
 0.11
chr4_44451115_44451507 0.13 KCTD8
 potassium channel tetramerization domain containing 8
 487
 0.76
chr11_126872809_126873319 0.13 KIRREL3-AS3
 KIRREL3 antisense RNA 3
 259
 0.89
chr12_54391177_54391923 0.13 HOXC-AS2
 HOXC cluster antisense RNA 2
 981
 0.22
chr17_38500769_38502147 0.13 RARA
 retinoic acid receptor, alpha
 35
 0.95
chr11_67078749_67078900 0.13 SSH3
 slingshot protein phosphatase 3
 3696
 0.13
chr12_85305887_85306488 0.13 SLC6A15
 solute carrier family 6 (neutral amino acid transporter), member 15
 384
 0.92
chr19_3097315_3097524 0.13 GNA11
 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
 3011
 0.15
chr19_35606414_35606565 0.13 FXYD3
 FXYD domain containing ion transport regulator 3
 243
 0.84
chr22_25508803_25509083 0.13 CTA-221G9.11
284
 0.93
chr1_214397865_214398571 0.13 SMYD2
 SET and MYND domain containing 2
 56358
 0.16
chr15_97311897_97312048 0.13 SPATA8-AS1
 SPATA8 antisense RNA 1 (head to head)
 12912
 0.22
chr4_111118316_111119494 0.12 ELOVL6
 ELOVL fatty acid elongase 6
 904
 0.69
chr16_2517636_2518674 0.12 RP11-715J22.2
59
 0.92
chr9_117050791_117050942 0.12 ORM1
 orosomucoid 1
 34470
 0.15
chr6_54711000_54712080 0.12 FAM83B
 family with sequence similarity 83, member B
 29
 0.98
chr21_47167661_47167812 0.12 PRED60
22269
 0.22
chr10_21462508_21463481 0.12 NEBL-AS1
 NEBL antisense RNA 1
 51
 0.59
chrX_107681107_107681335 0.12 COL4A6
 collagen, type IV, alpha 6
 335
 0.88
chr16_52579338_52579756 0.12 TOX3
 TOX high mobility group box family member 3
 1373
 0.61
chr12_131199797_131200212 0.12 RIMBP2
 RIMS binding protein 2
 822
 0.73
chr12_6930752_6931082 0.12 GPR162
 G protein-coupled receptor 162
 47
 0.93
chr19_11494273_11494666 0.12 EPOR
 erythropoietin receptor
 519
 0.56
chr20_55205919_55206207 0.12 TFAP2C
 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
 125
 0.96
chr14_103394355_103395516 0.12 AMN
 amnion associated transmembrane protein
 211
 0.92
chr16_66443392_66443543 0.12 CDH5
 cadherin 5, type 2 (vascular endothelium)
 14109
 0.16
chr13_114505022_114505231 0.12 GAS6-AS1
 GAS6 antisense RNA 1
 13477
 0.2
chr16_29910903_29911054 0.12 SEZ6L2
 seizure related 6 homolog (mouse)-like 2
 110
 0.86
chr10_5566594_5566745 0.12 CALML3
 calmodulin-like 3
 255
 0.81
chr3_133748771_133749015 0.11 SLCO2A1
 solute carrier organic anion transporter family, member 2A1
 27
 0.99
chr3_128207705_128209147 0.11 RP11-475N22.4
326
 0.79
chr11_57365224_57366004 0.11 SERPING1
 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
 338
 0.8
chr11_26003807_26004057 0.11 ANO3
 anoctamin 3
 206897
 0.03
chr20_62573957_62574108 0.11 ENSG00000207554
 .
 47
 0.9
chr10_14215918_14216465 0.11 RP11-397C18.2
99908
 0.08
chr14_38064845_38065186 0.11 TTC6
 tetratricopeptide repeat domain 6
 37
 0.95
chr6_80656707_80657785 0.11 ELOVL4
 ELOVL fatty acid elongase 4
 51
 0.98
chr5_32991795_32991946 0.11 AC026703.1
202925
 0.03
chr12_125105824_125106359 0.11 NCOR2
 nuclear receptor corepressor 2
 54081
 0.17
chr6_5026569_5027044 0.11 ENSG00000252419
 .
 19529
 0.19
chr9_130341109_130341430 0.11 FAM129B
 family with sequence similarity 129, member B
 1
 0.98
chr10_77156249_77156959 0.11 ENSG00000237149
 .
 4673
 0.21
chr5_142000582_142000950 0.11 FGF1
 fibroblast growth factor 1 (acidic)
 141
 0.96
chr14_93510273_93510424 0.11 ITPK1
 inositol-tetrakisphosphate 1-kinase
 22355
 0.18
chr4_144256878_144257439 0.11 GAB1
 GRB2-associated binding protein 1
 757
 0.67
chr16_73104339_73104801 0.11 ZFHX3
 zinc finger homeobox 3
 10973
 0.24
chr14_101543718_101544133 0.11 ENSG00000207959
 .
 10864
 0.02
chr2_219155938_219157236 0.11 TMBIM1
 transmembrane BAX inhibitor motif containing 1
 649
 0.55
chr12_41085967_41086118 0.11 CNTN1
 contactin 1
 202
 0.97
chr8_42063953_42065062 0.11 PLAT
 plasminogen activator, tissue
 576
 0.71
chr12_54784143_54784294 0.11 ZNF385A
 zinc finger protein 385A
 847
 0.43
chr19_5261127_5261342 0.11 PTPRS
 protein tyrosine phosphatase, receptor type, S
 24940
 0.21
chr5_149979916_149980067 0.11 SYNPO
 synaptopodin
 651
 0.67
chr4_1035336_1035962 0.11 FGFRL1
 fibroblast growth factor receptor-like 1
 29410
 0.11
chr15_29966806_29967093 0.11 RP11-680F8.1
245
 0.94
chr19_5880770_5880921 0.11 FUT5
 fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
 10294
 0.08
chr10_48355429_48355580 0.11 ZNF488
 zinc finger protein 488
 403
 0.79
chr11_128812512_128812811 0.11 TP53AIP1
 tumor protein p53 regulated apoptosis inducing protein 1
 161
 0.95
chr9_109625378_109625771 0.11 ZNF462
 zinc finger protein 462
 127
 0.97
chr15_43985556_43986365 0.10 CKMT1A
 creatine kinase, mitochondrial 1A
 109
 0.93
chr17_71301289_71301523 0.10 CDC42EP4
 CDC42 effector protein (Rho GTPase binding) 4
 6141
 0.2
chr9_87283365_87284204 0.10 NTRK2
 neurotrophic tyrosine kinase, receptor, type 2
 318
 0.95
chr4_4390270_4390555 0.10 NSG1
 Homo sapiens neuron specific gene family member 1 (NSG1), transcript variant 3, mRNA.
 1580
 0.45
chr22_36232318_36232521 0.10 RBFOX2
 RNA binding protein, fox-1 homolog (C. elegans) 2
 3846
 0.33
chr1_154973351_154974199 0.10 ZBTB7B
 zinc finger and BTB domain containing 7B
 1352
 0.2
chr1_13910269_13910760 0.10 PDPN
 podoplanin
 74
 0.97
chr19_39280125_39280276 0.10 LGALS7B
 lectin, galactoside-binding, soluble, 7B
 349
 0.73
chr16_73033974_73034214 0.10 AC002044.4
14281
 0.2
chr1_156099457_156100025 0.10 LMNA
 lamin A/C
 3147
 0.15
chr4_14817384_14817535 0.10 ENSG00000202449
 .
 125125
 0.06
chr12_57998166_57998701 0.10 DTX3
 deltex homolog 3 (Drosophila)
 11
 0.94
chr20_18037263_18037961 0.10 OVOL2
 ovo-like zinc finger 2
 909
 0.48
chr12_127865548_127865745 0.10 ENSG00000253089
 .
 59746
 0.16
chr8_143693973_143694253 0.10 ARC
 activity-regulated cytoskeleton-associated protein
 2720
 0.21
chr5_9782917_9783068 0.10 ENSG00000222054
 .
 21973
 0.24
chr11_395288_395439 0.10 PKP3
 plakophilin 3
 1120
 0.3
chr1_162666353_162666719 0.10 DDR2
 discoidin domain receptor tyrosine kinase 2
 64276
 0.1
chr11_126229473_126229631 0.10 ST3GAL4
 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
 3683
 0.19
chr13_114540399_114540680 0.10 GAS6
 growth arrest-specific 6
 1522
 0.45
chr7_69786510_69786661 0.10 AUTS2
 autism susceptibility candidate 2
 407540
 0.01
chr2_176961922_176962434 0.10 HOXD12
 homeobox D12
 2280
 0.13
chr5_132111918_132112304 0.10 SEPT8
 septin 8
 453
 0.75
chr17_37783095_37783466 0.10 PPP1R1B
 protein phosphatase 1, regulatory (inhibitor) subunit 1B
 75
 0.95
chr11_1221437_1221588 0.09 MUC5B
 mucin 5B, oligomeric mucus/gel-forming
 22784
 0.15
chr16_65154751_65155029 0.09 CDH11
 cadherin 11, type 2, OB-cadherin (osteoblast)
 943
 0.75
chr4_6472295_6472644 0.09 PPP2R2C
 protein phosphatase 2, regulatory subunit B, gamma
 1704
 0.48
chr1_150232422_150232573 0.09 ENSG00000238526
 .
 1596
 0.18
chr14_74100045_74101313 0.09 RP3-414A15.10
35
 0.96
chr15_43885730_43886468 0.09 CKMT1B
 creatine kinase, mitochondrial 1B
 42
 0.95
chr7_27197659_27197810 0.09 HOXA7
 homeobox A7
 179
 0.83
chr1_27357912_27358708 0.09 FAM46B
 family with sequence similarity 46, member B
 18983
 0.16
chr2_91846908_91847477 0.09 AC027612.6
783
 0.68
chr5_172721162_172721383 0.09 ENSG00000252169
 .
 1650
 0.36
chr12_112818867_112820166 0.09 HECTD4
 HECT domain containing E3 ubiquitin protein ligase 4
 380
 0.87
chr7_150822785_150823007 0.09 AGAP3
 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
 7600
 0.11
chr2_121199524_121199751 0.09 LINC01101
 long intergenic non-protein coding RNA 1101
 24060
 0.24
chr1_3615954_3616105 0.09 TP73
 tumor protein p73
 1407
 0.29
chr12_52919023_52919174 0.09 AC055736.1
 Uncharacterized protein
 3817
 0.13
chr17_41476988_41477313 0.09 ARL4D
 ADP-ribosylation factor-like 4D
 823
 0.46
chr6_156488488_156489372 0.09 ENSG00000212295
 .
 210954
 0.02
chr2_242499136_242499442 0.09 BOK-AS1
 BOK antisense RNA 1
 897
 0.38
chr17_46674549_46675551 0.09 HOXB-AS3
 HOXB cluster antisense RNA 3
 1249
 0.2
chr15_96897591_96898313 0.09 AC087477.1
 Uncharacterized protein
 6535
 0.18
chr22_43115644_43116713 0.09 A4GALT
 alpha 1,4-galactosyltransferase
 24539
 0.15
chr8_1778332_1778483 0.09 ARHGEF10
 Rho guanine nucleotide exchange factor (GEF) 10
 4130
 0.24
chr11_57089871_57090022 0.09 TNKS1BP1
 tankyrase 1 binding protein 1, 182kDa
 137
 0.92
chr14_85999097_85999705 0.09 FLRT2
 fibronectin leucine rich transmembrane protein 2
 2829
 0.32
chr1_56111785_56112048 0.09 ENSG00000272051
 .
 161271
 0.04
chr2_172959441_172959633 0.09 DLX2
 distal-less homeobox 2
 8091
 0.21
chr2_11123558_11123709 0.09 KCNF1
 potassium voltage-gated channel, subfamily F, member 1
 71570
 0.1
chr9_1050369_1050635 0.09 DMRT2
 doublesex and mab-3 related transcription factor 2
 118
 0.98
chr6_35360979_35361130 0.09 PPARD
 peroxisome proliferator-activated receptor delta
 50652
 0.11
chr12_50450066_50450217 0.09 ASIC1
 acid-sensing (proton-gated) ion channel 1
 1190
 0.36
chr7_31781380_31781531 0.09 ENSG00000223070
 .
 52407
 0.15
chr17_77030183_77030334 0.09 C1QTNF1
 C1q and tumor necrosis factor related protein 1
 9
 0.97
chr14_100004080_100004231 0.09 CCDC85C
 coiled-coil domain containing 85C
 1730
 0.33
chr15_70702879_70703030 0.09 ENSG00000200216
 .
 217379
 0.02
chr19_40785123_40785301 0.09 AKT2
 v-akt murine thymoma viral oncogene homolog 2
 334
 0.77
chr15_71036630_71036796 0.09 UACA
 uveal autoantigen with coiled-coil domains and ankyrin repeats
 19056
 0.21
chr15_37387605_37387763 0.09 MEIS2
 Meis homeobox 2
 462
 0.84
chr9_124517266_124517417 0.09 DAB2IP
 DAB2 interacting protein
 12277
 0.25
chr12_52627039_52627830 0.09 KRT7
 keratin 7
 536
 0.63
chr1_41898610_41898871 0.09 ENSG00000252563
 .
 33959
 0.16
chr4_20703224_20703375 0.09 PACRGL
 PARK2 co-regulated-like
 1195
 0.6
chr2_99954548_99954935 0.09 EIF5B
 eukaryotic translation initiation factor 5B
 925
 0.48
chr11_1220573_1220724 0.09 MUC5B
 mucin 5B, oligomeric mucus/gel-forming
 23648
 0.15
chr1_161167898_161168112 0.09 ADAMTS4
 ADAM metallopeptidase with thrombospondin type 1 motif, 4
 838
 0.28
chr19_10736216_10736429 0.09 SLC44A2
 solute carrier family 44 (choline transporter), member 2
 121
 0.93
chrX_133147131_133147282 0.09 GPC3
 glypican 3
 27284
 0.21
chr2_73384123_73384274 0.09 RAB11FIP5
 RAB11 family interacting protein 5 (class I)
 44052
 0.1
chr2_232538307_232538458 0.09 ENSG00000239202
 .
 27398
 0.13
chr4_23975239_23975390 0.09 PPARGC1A
 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
 83614
 0.11
chr7_95403720_95403871 0.09 DYNC1I1
 dynein, cytoplasmic 1, intermediate chain 1
 1879
 0.48
chr8_75232625_75233066 0.09 JPH1
 junctophilin 1
 718
 0.68
chr2_106886104_106886958 0.09 UXS1
 UDP-glucuronate decarboxylase 1
 75736
 0.1
chr9_140199344_140199495 0.09 NRARP
 NOTCH-regulated ankyrin repeat protein
 2716
 0.14
chr18_77929070_77929234 0.09 AC139100.3
12411
 0.18
chr3_159481083_159481637 0.09 IQCJ-SCHIP1
 IQCJ-SCHIP1 readthrough
 142
 0.96
chr2_56412283_56412467 0.09 AC007743.1
327
 0.83
chr18_10560102_10560331 0.09 NAPG
 N-ethylmaleimide-sensitive factor attachment protein, gamma
 33807
 0.19
chr19_39263775_39263926 0.09 LGALS7
 lectin, galactoside-binding, soluble, 7
 222
 0.85
chr1_44399484_44399885 0.09 ARTN
 artemin
 166
 0.92
chr14_86000288_86000530 0.09 FLRT2
 fibronectin leucine rich transmembrane protein 2
 3837
 0.29
chr1_16472071_16472222 0.09 RP11-276H7.2
9560
 0.12
chr22_31644271_31644422 0.09 LIMK2
 LIM domain kinase 2
 2
 0.96
chr3_138663757_138663928 0.09 FOXL2
 forkhead box L2
 2140
 0.26
chr18_8983307_8983458 0.09 NDUFV2
 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
 119246
 0.05
chr13_27334023_27334664 0.09 GPR12
 G protein-coupled receptor 12
 84
 0.98
chr7_27153769_27154326 0.09 HOXA-AS2
 HOXA cluster antisense RNA 2
 492
 0.41
chr3_49170263_49170561 0.09 LAMB2
 laminin, beta 2 (laminin S)
 41
 0.95
chr1_45083000_45083241 0.09 RNF220
 ring finger protein 220
 8878
 0.17
chr17_78165764_78166017 0.09 CARD14
 caspase recruitment domain family, member 14
 7916
 0.14
chr22_46980499_46980650 0.09 GRAMD4
 GRAM domain containing 4
 7548
 0.22
chr22_29704652_29704931 0.09 GAS2L1
 growth arrest-specific 2 like 1
 1743
 0.22
chr18_24083489_24083640 0.09 KCTD1
 potassium channel tetramerization domain containing 1
 43399
 0.17
chr9_133539320_133539471 0.09 PRDM12
 PR domain containing 12
 586
 0.77
chr10_13889361_13889512 0.08 FRMD4A
 FERM domain containing 4A
 11476
 0.24
chr16_84676084_84676235 0.08 KLHL36
 kelch-like family member 36
 5972
 0.19
chr22_47135360_47135511 0.08 CERK
 ceramide kinase
 1277
 0.45
chr19_4813287_4813441 0.08 AC005523.2
17793
 0.1
chr1_228337001_228337152 0.08 GJC2
 gap junction protein, gamma 2, 47kDa
 477
 0.67
chr17_56494195_56494346 0.08 RNF43
 ring finger protein 43
 176
 0.93
chr1_27190573_27190827 0.08 SFN
 stratifin
 1067
 0.35
chr20_32899455_32899940 0.08 AHCY
 adenosylhomocysteinase
 89
 0.96
chr2_182521265_182521506 0.08 CERKL
 ceramide kinase-like
 348
 0.89
chr8_104511456_104511779 0.08 RP11-1C8.4
169
 0.93
chr5_73502284_73502435 0.08 ENSG00000222551
 .
 65231
 0.14
chr1_185703154_185703536 0.08 HMCN1
 hemicentin 1
 338
 0.93
chr16_30022591_30022974 0.08 DOC2A
 double C2-like domains, alpha
 40
 0.94
chr10_123357016_123357770 0.08 FGFR2
 fibroblast growth factor receptor 2
 205
 0.97
chrX_9754895_9755291 0.08 SHROOM2
 shroom family member 2
 597
 0.54

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of GTF2I

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0061364 apoptotic process involved in luteolysis(GO:0061364)
0.1 0.2 GO:0060677 ureteric bud elongation(GO:0060677)
0.1 0.2 GO:0060737 prostate gland morphogenetic growth(GO:0060737)
0.1 0.2 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.1 0.2 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367)
0.0 0.1 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.1 GO:0048859 formation of anatomical boundary(GO:0048859)
0.0 0.1 GO:0072367 regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0 0.1 GO:0015820 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 0.2 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.1 GO:0003181 atrioventricular valve development(GO:0003171) atrioventricular valve morphogenesis(GO:0003181)
0.0 0.1 GO:0071504 cellular response to heparin(GO:0071504)
0.0 0.1 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.0 0.0 GO:0003308 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0 0.2 GO:0036303 lymphangiogenesis(GO:0001946) lymph vessel morphogenesis(GO:0036303)
0.0 0.2 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.0 GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910)
0.0 0.1 GO:0070366 regulation of hepatocyte differentiation(GO:0070366)
0.0 0.1 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.0 0.1 GO:0016115 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0 0.1 GO:0045630 positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.0 0.1 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0 0.1 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 0.1 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.0 GO:0060836 lymphatic endothelial cell differentiation(GO:0060836)
0.0 0.1 GO:0002072 optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0 0.1 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0 0.1 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0 0.0 GO:0010193 response to ozone(GO:0010193)
0.0 0.0 GO:0009111 vitamin catabolic process(GO:0009111) fat-soluble vitamin catabolic process(GO:0042363)
0.0 0.0 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.1 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 0.1 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.2 GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0003337) metanephric renal vesicle morphogenesis(GO:0072283)
0.0 0.0 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.1 GO:0060317 cardiac epithelial to mesenchymal transition(GO:0060317)
0.0 0.1 GO:0021978 telencephalon regionalization(GO:0021978)
0.0 0.1 GO:0022601 menstrual cycle phase(GO:0022601)
0.0 0.0 GO:0003099 positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.0 0.1 GO:0032236 obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0 0.2 GO:0021904 dorsal/ventral neural tube patterning(GO:0021904)
0.0 0.1 GO:0031269 pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.0 GO:0006154 adenosine catabolic process(GO:0006154)
0.0 0.1 GO:0010002 cardioblast differentiation(GO:0010002)
0.0 0.1 GO:0008218 bioluminescence(GO:0008218)
0.0 0.0 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0 0.1 GO:1903392 negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)
0.0 0.1 GO:0060684 epithelial-mesenchymal cell signaling(GO:0060684)
0.0 0.0 GO:0010159 specification of organ position(GO:0010159)
0.0 0.0 GO:0045112 integrin biosynthetic process(GO:0045112)
0.0 0.1 GO:0014721 voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0 0.0 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.0 0.1 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0 0.1 GO:0021898 commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0 0.1 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.1 GO:0014850 response to muscle activity(GO:0014850)
0.0 0.1 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.1 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.0 GO:0002019 regulation of renal output by angiotensin(GO:0002019)
0.0 0.1 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.0 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0 0.1 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.0 GO:0035588 adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 0.1 GO:0030644 cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0 0.1 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.0 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.0 0.0 GO:0072201 negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0 0.0 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.0 0.1 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.0 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.1 GO:0006538 glutamate catabolic process(GO:0006538)
0.0 0.0 GO:2000008 regulation of protein localization to cell surface(GO:2000008)
0.0 0.0 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.0 0.1 GO:0061430 bone trabecula formation(GO:0060346) bone trabecula morphogenesis(GO:0061430)
0.0 0.0 GO:0031268 pseudopodium organization(GO:0031268)
0.0 0.0 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.0 GO:0045605 negative regulation of epidermal cell differentiation(GO:0045605)
0.0 0.1 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.1 GO:0002238 response to molecule of fungal origin(GO:0002238)
0.0 0.0 GO:0009822 alkaloid catabolic process(GO:0009822)
0.0 0.2 GO:0043392 negative regulation of DNA binding(GO:0043392)
0.0 0.0 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.0 0.0 GO:0072048 pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048) pattern specification involved in metanephros development(GO:0072268)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.1 GO:0010544 negative regulation of platelet activation(GO:0010544)
0.0 0.1 GO:0048714 positive regulation of oligodendrocyte differentiation(GO:0048714)
0.0 0.0 GO:0048143 astrocyte activation(GO:0048143)
0.0 0.0 GO:0032898 neurotrophin production(GO:0032898)
0.0 0.1 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.1 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)
0.0 0.0 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0 0.0 GO:0001554 luteolysis(GO:0001554)
0.0 0.0 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0 0.0 GO:0003170 heart valve development(GO:0003170) heart valve morphogenesis(GO:0003179)
0.0 0.0 GO:0071428 rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.0 0.0 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.0 0.0 GO:0072109 glomerular mesangium development(GO:0072109)
0.0 0.1 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.0 GO:0060463 lung lobe development(GO:0060462) lung lobe morphogenesis(GO:0060463)
0.0 0.1 GO:1901678 iron coordination entity transport(GO:1901678)
0.0 0.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.0 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.0 0.2 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
0.0 0.2 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
0.0 0.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.0 GO:0046021 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0 0.1 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 0.0 GO:0010842 retina layer formation(GO:0010842)
0.0 0.0 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.0 0.0 GO:0090218 positive regulation of lipid kinase activity(GO:0090218)
0.0 0.0 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.0 0.0 GO:0072176 nephric duct development(GO:0072176)
0.0 0.0 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 0.1 GO:0043252 sodium-independent organic anion transport(GO:0043252)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 GO:0043260 laminin-11 complex(GO:0043260)
0.0 0.1 GO:0043259 laminin-10 complex(GO:0043259)
0.0 0.2 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.1 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.1 GO:0005638 lamin filament(GO:0005638)
0.0 0.1 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.3 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.1 GO:0010369 chromocenter(GO:0010369)
0.0 0.1 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.0 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.1 GO:0032279 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0 0.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.1 GO:0005861 troponin complex(GO:0005861)
0.0 0.1 GO:0030673 axolemma(GO:0030673)
0.0 0.0 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.0 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.1 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.0 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0001527 microfibril(GO:0001527)
0.0 0.1 GO:0031430 M band(GO:0031430)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.0 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.1 GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.2 GO:0008517 folic acid transporter activity(GO:0008517)
0.0 0.2 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.1 GO:0070215 obsolete MDM2 binding(GO:0070215)
0.0 0.1 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.1 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.1 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.2 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.0 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0 0.0 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.1 GO:0031014 troponin T binding(GO:0031014)
0.0 0.1 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.1 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.1 GO:0031705 bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0 0.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0 0.1 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.0 0.0 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.0 GO:0005113 patched binding(GO:0005113)
0.0 0.0 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.0 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.0 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.1 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0 0.1 GO:0009922 fatty acid elongase activity(GO:0009922)
0.0 0.0 GO:0051733 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.0 GO:0042156 obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0 0.1 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 0.1 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 0.0 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.0 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.1 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.2 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.0 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 0.1 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.1 GO:0005112 Notch binding(GO:0005112)
0.0 0.0 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0 0.0 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 0.1 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.1 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.1 GO:0001619 obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0 0.0 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.0 GO:0042808 obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0 0.0 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 0.3 GO:0008378 galactosyltransferase activity(GO:0008378)
0.0 0.1 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.0 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.1 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.0 GO:0004103 choline kinase activity(GO:0004103)
0.0 0.0 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.0 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.0 0.0 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.0 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.0 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.3 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.0 0.0 REACTOME SIGNALING BY NOTCH3 Genes involved in Signaling by NOTCH3
0.0 0.3 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.0 0.2 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.0 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 0.1 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions