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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for GZF1

Z-value: 0.78

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Transcription factors associated with GZF1

Gene Symbol	Gene ID	Gene Info
GZF1 Ensembl NCBI GeneCards UniProt	ENSG00000125812.11	GZF1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
GZF1	chr20_23342076_23342460	519	0.643610	0.69	3.8e-02	Click!
GZF1	chr20_23346779_23346930	1833	0.210527	-0.67	5.0e-02	Click!
GZF1	chr20_23343011_23343833	465	0.690043	0.32	4.0e-01	Click!

Activity of the GZF1 motif across conditions

Conditions sorted by the z-value of the GZF1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr10_118652704_118652966	0.44	ENO4	enolase family member 4	34290	0.17
chr16_1257169_1257320	0.42	RP11-616M22.3		120	0.92
chr16_375168_375449	0.41	AXIN1	axin 1	27141	0.09
chr2_29537347_29537508	0.36	ALK	anaplastic lymphoma receptor tyrosine kinase	91167	0.08
chr12_116985994_116986414	0.30	MAP1LC3B2	microtubule-associated protein 1 light chain 3 beta 2	10982	0.28
chr20_42086642_42086854	0.30	SRSF6	serine/arginine-rich splicing factor 6	180	0.93
chr10_104005591_104006435	0.29	GBF1	golgi brefeldin A resistant guanine nucleotide exchange factor 1	724	0.58
chr10_14698721_14698872	0.29	RP11-7C6.1		4055	0.23
chr7_64712185_64712407	0.29	ENSG00000265175	.	16013	0.22
chr12_32115176_32115327	0.27	KIAA1551	KIAA1551	172	0.96
chr6_157342303_157342500	0.27	RP1-137K2.2		98439	0.08
chr8_142427875_142428034	0.27	PTP4A3	protein tyrosine phosphatase type IVA, member 3	4053	0.16
chr8_21916945_21917106	0.26	DMTN	dematin actin binding protein	291	0.84
chr11_96656080_96656231	0.25	ENSG00000200411	.	448299	0.01
chr5_126323849_126324159	0.25	MARCH3	membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase	42496	0.18
chr2_27603785_27604012	0.25	ZNF513	zinc finger protein 513	241	0.83
chr12_53846681_53847472	0.25	PCBP2	poly(rC) binding protein 2	448	0.72
chr5_132158669_132158820	0.24	SHROOM1	shroom family member 1	3088	0.15
chr14_75894369_75894594	0.24	RP11-293M10.6		37	0.52
chrX_75392544_75392813	0.24	PBDC1	polysaccharide biosynthesis domain containing 1	93	0.98
chr9_133556690_133556909	0.23	EXOSC2	exosome component 2	12309	0.18
chr12_11699256_11699407	0.22	ENSG00000251747	.	82	0.97
chr14_21979649_21979818	0.22	METTL3	methyltransferase like 3	216	0.9
chr14_52739518_52739669	0.22	PTGDR	prostaglandin D2 receptor (DP)	5063	0.28
chr1_153643822_153644080	0.22	ILF2	interleukin enhancer binding factor 2	427	0.65
chr14_106495447_106495598	0.22	IGHVIII-5-1	immunoglobulin heavy variable (III)-5-1 (pseudogene)	474	0.43
chr20_34077433_34077600	0.22	RP3-477O4.14		1227	0.32
chr19_49148382_49148554	0.21	CA11	carbonic anhydrase XI	1101	0.28
chr9_139743848_139744034	0.21	PHPT1	phosphohistidine phosphatase 1	395	0.63
chrX_129535378_129535825	0.20	RBMX2	RNA binding motif protein, X-linked 2	342	0.89
chr1_27683876_27684079	0.20	MAP3K6	mitogen-activated protein kinase kinase kinase 6	1015	0.4
chr19_3557088_3557331	0.20	MFSD12	major facilitator superfamily domain containing 12	192	0.87
chr7_45019061_45019212	0.20	MYO1G	myosin IG	439	0.76
chr21_15916676_15916915	0.20	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	1867	0.42
chr3_45017798_45018180	0.20	EXOSC7	exosome component 7	267	0.53
chr1_197170699_197171135	0.19	CRB1	crumbs homolog 1 (Drosophila)	325	0.84
chr6_106545216_106545824	0.19	PRDM1	PR domain containing 1, with ZNF domain	961	0.58
chr8_117885462_117886204	0.19	RAD21	RAD21 homolog (S. pombe)	766	0.36
chr12_120662827_120663239	0.19	PXN	paxillin	480	0.71
chr2_187351379_187351888	0.19	ZC3H15	zinc finger CCCH-type containing 15	653	0.72
chr3_156393455_156393974	0.19	TIPARP	TCDD-inducible poly(ADP-ribose) polymerase	356	0.85
chr12_3162069_3162220	0.19	TSPAN9	tetraspanin 9	24377	0.17
chr1_199878058_199878346	0.18	ENSG00000200139	.	20915	0.24
chr1_38260135_38260459	0.18	MANEAL	mannosidase, endo-alpha-like	142	0.91
chr6_122792252_122792563	0.18	SERINC1	serine incorporator 1	560	0.52
chr14_50319523_50319960	0.18	NEMF	nuclear export mediator factor	180	0.85
chr8_6566608_6567048	0.18	AGPAT5	1-acylglycerol-3-phosphate O-acyltransferase 5	614	0.61
chr5_67580975_67581126	0.18	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	3146	0.37
chr3_52718835_52719171	0.18	PBRM1	polybromo 1	591	0.42
chrX_106956955_106957175	0.18	TSC22D3	TSC22 domain family, member 3	2566	0.34
chr6_89789489_89789998	0.18	RP11-63L7.5		643	0.43
chr12_127630819_127631001	0.18	ENSG00000239776	.	19762	0.3
chr2_28836714_28836865	0.18	PLB1	phospholipase B1	12003	0.21
chr14_102227472_102227811	0.17	PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	494	0.78
chr7_36305572_36305723	0.17	EEPD1	endonuclease/exonuclease/phosphatase family domain containing 1	31106	0.15
chr8_21769341_21769492	0.17	DOK2	docking protein 2, 56kDa	1758	0.36
chr11_36423391_36423542	0.17	PRR5L	proline rich 5 like	851	0.61
chr22_30662105_30662275	0.17	OSM	oncostatin M	383	0.75
chr12_104458290_104458598	0.16	HCFC2	host cell factor C2	148	0.82
chr2_134877443_134877671	0.16	MGAT5	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	196	0.96
chr8_29953492_29954050	0.16	LEPROTL1	leptin receptor overlapping transcript-like 1	606	0.68
chr5_473388_473548	0.16	ENSG00000225138	.	117	0.68
chr7_105362356_105362507	0.16	ATXN7L1	ataxin 7-like 1	30347	0.23
chr6_34112105_34112270	0.16	GRM4	glutamate receptor, metabotropic 4	1670	0.44
chr21_38073571_38073742	0.16	AP000697.6		208	0.93
chr16_89557343_89557542	0.16	ANKRD11	ankyrin repeat domain 11	473	0.69
chr3_158390470_158390795	0.16	LXN	latexin	150	0.95
chr7_156803754_156804127	0.15	MNX1-AS1	MNX1 antisense RNA 1 (head to head)	441	0.56
chr1_92946934_92947085	0.15	GFI1	growth factor independent 1 transcription repressor	2502	0.37
chr22_31619723_31619874	0.15	ENSG00000199695	.	959	0.4
chrX_102631036_102631748	0.15	NGFRAP1	nerve growth factor receptor (TNFRSF16) associated protein 1	57	0.97
chr10_103879598_103879834	0.15	LDB1	LIM domain binding 1	494	0.73
chr3_81472677_81472828	0.15	ENSG00000222389	.	85875	0.11
chr16_67876459_67876770	0.15	THAP11	THAP domain containing 11	401	0.44
chr12_122326739_122327128	0.15	PSMD9	proteasome (prosome, macropain) 26S subunit, non-ATPase, 9	241	0.9
chr9_135117163_135117384	0.15	ENSG00000221105	.	27011	0.2
chr5_170814799_170815118	0.15	NPM1	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	73	0.95
chr17_73773061_73773428	0.15	H3F3B	H3 histone, family 3B (H3.3B)	2123	0.16
chr19_58987134_58987390	0.14	CTD-2619J13.23		132	0.64
chr12_125473806_125474002	0.14	DHX37	DEAH (Asp-Glu-Ala-His) box polypeptide 37	237	0.93
chr20_61550921_61551072	0.14	DIDO1	death inducer-obliterator 1	5238	0.16
chr6_167411127_167411495	0.14	ENSG00000265828	.	89	0.93
chr16_68452108_68452259	0.14	SMPD3	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)	30212	0.12
chr1_239551018_239551169	0.14	CHRM3	cholinergic receptor, muscarinic 3	241280	0.02
chr3_135969234_135969511	0.14	PCCB	propionyl CoA carboxylase, beta polypeptide	155	0.97
chr15_31765016_31765167	0.14	KLF13	Kruppel-like factor 13	106734	0.07
chr4_82135724_82136079	0.14	PRKG2	protein kinase, cGMP-dependent, type II	287	0.94
chr13_53192037_53192369	0.14	HNRNPA1L2	heterogeneous nuclear ribonucleoprotein A1-like 2	598	0.79
chr8_135844464_135844657	0.14	ENSG00000199153	.	27372	0.21
chr21_36262594_36262745	0.14	RUNX1	runt-related transcription factor 1	582	0.85
chr20_62612476_62612847	0.14	PRPF6	pre-mRNA processing factor 6	173	0.87
chr9_74378842_74379095	0.14	TMEM2	transmembrane protein 2	4334	0.34
chr6_57181574_57181908	0.13	PRIM2	primase, DNA, polypeptide 2 (58kDa)	681	0.78
chr6_42418365_42418744	0.13	TRERF1	transcriptional regulating factor 1	445	0.85
chr6_7108626_7109201	0.13	RREB1	ras responsive element binding protein 1	649	0.77
chr9_95877171_95877322	0.13	C9orf89	chromosome 9 open reading frame 89	18746	0.14
chr6_30524774_30525039	0.13	GNL1	guanine nucleotide binding protein-like 1	45	0.63
chr5_133449213_133449364	0.13	TCF7	transcription factor 7 (T-cell specific, HMG-box)	1114	0.56
chr14_36788990_36789756	0.13	MBIP	MAP3K12 binding inhibitory protein 1	297	0.92
chr11_2502582_2502733	0.13	KCNQ1	potassium voltage-gated channel, KQT-like subfamily, member 1	19540	0.16
chr12_90378520_90378671	0.13	ENSG00000252823	.	230759	0.02
chr10_106083791_106084156	0.13	ITPRIP	inositol 1,4,5-trisphosphate receptor interacting protein	4709	0.15
chr18_60988479_60988630	0.13	BCL2	B-cell CLL/lymphoma 2	1193	0.44
chr13_73355012_73355163	0.13	DIS3	DIS3 mitotic control homolog (S. cerevisiae)	976	0.39
chr9_80625845_80626079	0.13	GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	19558	0.28
chr21_42258267_42258418	0.13	DSCAM	Down syndrome cell adhesion molecule	39277	0.21
chrX_153618503_153618757	0.13	RPL10	ribosomal protein L10	6865	0.08
chrX_75365570_75365805	0.12	PBDC1	polysaccharide biosynthesis domain containing 1	27084	0.25
chr6_109800480_109800632	0.12	ZBTB24	zinc finger and BTB domain containing 24	3884	0.14
chr1_27951925_27952076	0.12	FGR	feline Gardner-Rasheed sarcoma viral oncogene homolog	646	0.63
chr12_11803481_11804350	0.12	ETV6	ets variant 6	1127	0.62
chr2_203775980_203776689	0.12	CARF	calcium responsive transcription factor	603	0.45
chr2_220042618_220042887	0.12	CNPPD1	cyclin Pas1/PHO80 domain containing 1	76	0.53
chr5_175962769_175963088	0.12	RNF44	ring finger protein 44	1493	0.28
chr3_52007652_52007993	0.12	ABHD14A	abhydrolase domain containing 14A	122	0.44
chr3_185654118_185654306	0.12	TRA2B	transformer 2 beta homolog (Drosophila)	1589	0.4
chr4_155220038_155220189	0.12	ENSG00000264137	.	80052	0.1
chr1_206135676_206135961	0.12	FAM72A	family with sequence similarity 72, member A	1419	0.38
chr1_26758171_26758572	0.12	DHDDS	dehydrodolichyl diphosphate synthase	436	0.76
chr8_146175786_146175956	0.12	ZNF16	zinc finger protein 16	110	0.96
chr5_149521280_149521431	0.12	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	4355	0.17
chr10_104005118_104005269	0.12	GBF1	golgi brefeldin A resistant guanine nucleotide exchange factor 1	96	0.95
chr17_56407127_56407278	0.12	BZRAP1-AS1	BZRAP1 antisense RNA 1	236	0.8
chrX_153570073_153570387	0.12	XX-FW83128A1.2		6843	0.1
chr2_27008209_27008614	0.12	CENPA	centromere protein A	454	0.81
chr1_1004234_1004415	0.12	RNF223	ring finger protein 223	5363	0.1
chr6_24774737_24775060	0.12	GMNN	geminin, DNA replication inhibitor	261	0.9
chr12_9903163_9903484	0.12	CD69	CD69 molecule	10174	0.15
chr17_62222536_62222687	0.12	ENSG00000199753	.	832	0.44
chr9_108319921_108320392	0.12	RP11-235C23.5		154	0.64
chr1_202310113_202310440	0.12	UBE2T	ubiquitin-conjugating enzyme E2T (putative)	832	0.62
chr2_106777289_106777491	0.12	UXS1	UDP-glucuronate decarboxylase 1	309	0.92
chr3_120068350_120069016	0.12	RP11-174O3.3		326	0.63
chr14_70041081_70041336	0.12	CCDC177	Homo sapiens coiled-coil domain containing 177 (CCDC177), mRNA.	869	0.67
chr20_10903511_10903679	0.12	RP11-103J8.1		20663	0.27
chr11_36531965_36532300	0.12	TRAF6	TNF receptor-associated factor 6, E3 ubiquitin protein ligase	310	0.91
chr19_4633711_4633862	0.11	TNFAIP8L1	tumor necrosis factor, alpha-induced protein 8-like 1	5744	0.13
chr11_118489320_118489642	0.11	PHLDB1	pleckstrin homology-like domain, family B, member 1	11123	0.11
chr22_32806330_32806481	0.11	RTCB	RNA 2',3'-cyclic phosphate and 5'-OH ligase	1819	0.29
chr3_48693068_48693287	0.11	CELSR3	cadherin, EGF LAG seven-pass G-type receptor 3	7171	0.09
chr13_46627012_46627449	0.11	CPB2-AS1	CPB2 antisense RNA 1	193	0.67
chr12_8724646_8724797	0.11	ENSG00000238943	.	20351	0.12
chr1_7765903_7766129	0.11	CAMTA1	calmodulin binding transcription activator 1	30452	0.17
chr22_43355548_43355783	0.11	PACSIN2	protein kinase C and casein kinase substrate in neurons 2	219	0.95
chr12_102513335_102513786	0.11	NUP37	nucleoporin 37kDa	338	0.53
chr1_149813796_149814193	0.11	HIST2H2AA3	histone cluster 2, H2aa3	484	0.49
chr19_2237563_2237785	0.11	PLEKHJ1	pleckstrin homology domain containing, family J member 1	29	0.59
chr7_72936777_72937003	0.11	BAZ1B	bromodomain adjacent to zinc finger domain, 1B	282	0.88
chr20_5093003_5093662	0.11	TMEM230	transmembrane protein 230	67	0.94
chr16_11763075_11763345	0.11	SNN	stannin	940	0.56
chr5_162934649_162934884	0.11	MAT2B	methionine adenosyltransferase II, beta	2146	0.28
chr5_55287822_55288099	0.11	IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	2832	0.2
chr2_30448704_30448864	0.11	LBH	limb bud and heart development	5613	0.24
chr11_118868535_118868695	0.11	CCDC84	coiled-coil domain containing 84	237	0.79
chr17_74137986_74138137	0.11	RNF157-AS1	RNF157 antisense RNA 1	464	0.54
chr6_27841415_27841672	0.11	HIST1H4L	histone cluster 1, H4l	254	0.76
chr14_50087068_50087296	0.11	RPL36AL	ribosomal protein L36a-like	221	0.56
chr10_103576027_103576601	0.11	MGEA5	meningioma expressed antigen 5 (hyaluronidase)	1309	0.34
chr8_144373646_144373987	0.11	ZNF696	zinc finger protein 696	224	0.82
chr10_22541853_22542149	0.11	EBLN1	endogenous Bornavirus-like nucleoprotein 1	43051	0.13
chrX_154445779_154445930	0.11	VBP1	von Hippel-Lindau binding protein 1	1211	0.48
chr21_34864166_34864389	0.11	DNAJC28	DnaJ (Hsp40) homolog, subfamily C, member 28	250	0.87
chr16_46723241_46723448	0.11	ORC6	origin recognition complex, subunit 6	214	0.52
chr7_65762308_65762459	0.11	ENSG00000252126	.	46908	0.14
chr16_22217946_22218447	0.11	EEF2K	eukaryotic elongation factor-2 kinase	593	0.74
chr1_144593335_144593591	0.11	RP11-640M9.2		21668	0.2
chr6_88412249_88412889	0.11	AKIRIN2	akirin 2	642	0.73
chr6_11094046_11094248	0.10	SMIM13	small integral membrane protein 13	119	0.96
chr5_168729442_168729593	0.10	SLIT3	slit homolog 3 (Drosophila)	1384	0.54
chr17_18087734_18087959	0.10	RP11-258F1.1		135	0.69
chrX_24072030_24072308	0.10	EIF2S3	eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa	664	0.73
chr11_111957062_111957410	0.10	SDHD	succinate dehydrogenase complex, subunit D, integral membrane protein	261	0.49
chr3_176915816_176916502	0.10	TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	898	0.7
chr9_131133752_131134483	0.10	URM1	ubiquitin related modifier 1	467	0.68
chr2_43449640_43450246	0.10	ZFP36L2	ZFP36 ring finger protein-like 2	3805	0.27
chr3_171176304_171176455	0.10	TNIK	TRAF2 and NCK interacting kinase	1473	0.45
chrX_75368988_75369430	0.10	PBDC1	polysaccharide biosynthesis domain containing 1	23562	0.26
chr1_192842951_192843102	0.10	ENSG00000223075	.	2089	0.41
chr6_159072646_159072797	0.10	SYTL3	synaptotagmin-like 3	1675	0.35
chr6_64345134_64345489	0.10	PHF3	PHD finger protein 3	414	0.89
chr19_53104607_53104836	0.10	CTD-3099C6.11		2581	0.16
chr12_14926776_14927159	0.10	H2AFJ	H2A histone family, member J	303	0.82
chrX_9866552_9866703	0.10	SHROOM2	shroom family member 2	13785	0.2
chr22_32057584_32058186	0.10	PISD	phosphatidylserine decarboxylase	281	0.92
chr13_52767860_52768554	0.10	MRPS31P5	mitochondrial ribosomal protein S31 pseudogene 5	306	0.91
chr5_35857770_35858187	0.10	IL7R	interleukin 7 receptor	984	0.58
chr11_122050649_122050906	0.10	ENSG00000207994	.	27761	0.16
chr11_62529664_62529976	0.10	POLR2G	polymerase (RNA) II (DNA directed) polypeptide G	783	0.32
chr3_16351051_16351202	0.10	RP11-415F23.2		4820	0.19
chr1_241840893_241841044	0.10	WDR64	WD repeat domain 64	5914	0.23
chrX_124911556_124911707	0.10	ENSG00000222518	.	114732	0.07
chr1_42181439_42181590	0.10	HIVEP3	human immunodeficiency virus type I enhancer binding protein 3	14842	0.25
chr8_108509260_108510202	0.10	ANGPT1	angiopoietin 1	507	0.89
chr22_51021623_51022044	0.10	CHKB-AS1	CHKB antisense RNA 1 (head to head)	378	0.43
chr6_501893_502410	0.10	RP1-20B11.2		22020	0.26
chrX_41280637_41281001	0.10	NYX	nyctalopin	25868	0.18
chr6_47381977_47382964	0.10	ENSG00000266330	.	48182	0.14
chr9_137217336_137217895	0.10	RXRA	retinoid X receptor, alpha	811	0.72
chr9_136999905_137000059	0.10	WDR5	WD repeat domain 5	505	0.59
chr4_123072364_123072515	0.10	KIAA1109	KIAA1109	1049	0.65

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of GZF1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0045835	negative regulation of meiotic nuclear division(GO:0045835)
0.0	0.1	GO:0050961	detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0	0.1	GO:0032071	regulation of endodeoxyribonuclease activity(GO:0032071)
0.0	0.2	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.1	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.2	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.1	GO:0047484	regulation of response to osmotic stress(GO:0047484)
0.0	0.1	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0	0.3	GO:0048200	COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0	0.1	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.1	GO:0034723	DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.1	GO:0002326	B cell lineage commitment(GO:0002326)
0.0	0.1	GO:0015825	L-serine transport(GO:0015825)
0.0	0.1	GO:0030210	heparin biosynthetic process(GO:0030210)
0.0	0.1	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0	0.1	GO:0002540	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.1	GO:0000466	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000466)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.1	GO:1900120	regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.0	0.2	GO:0050687	negative regulation of defense response to virus(GO:0050687)
0.0	0.1	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0	0.1	GO:0035519	protein K29-linked ubiquitination(GO:0035519)
0.0	0.1	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.2	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.0	GO:0016048	detection of temperature stimulus(GO:0016048)
0.0	0.3	GO:0006376	mRNA splice site selection(GO:0006376)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0021801	cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0	0.1	GO:0000132	establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0	0.1	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.0	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.1	GO:0030490	maturation of SSU-rRNA(GO:0030490)
0.0	0.1	GO:0042541	hemoglobin biosynthetic process(GO:0042541)
0.0	0.1	GO:0021834	chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834)
0.0	0.0	GO:0070254	mucus secretion(GO:0070254)
0.0	0.2	GO:0001510	RNA methylation(GO:0001510)
0.0	0.1	GO:0032632	interleukin-3 production(GO:0032632)
0.0	0.1	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.1	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.1	GO:0032057	negative regulation of translational initiation in response to stress(GO:0032057)
0.0	0.1	GO:0002098	tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) tRNA thio-modification(GO:0034227)
0.0	0.0	GO:0014056	acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056) acetylcholine secretion(GO:0061526)
0.0	0.1	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.1	GO:0097205	regulation of glomerular filtration(GO:0003093) glomerular filtration(GO:0003094) renal filtration(GO:0097205) regulation of renal system process(GO:0098801)
0.0	0.1	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.1	GO:0071043	CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0	0.1	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.0	0.0	GO:0045006	DNA deamination(GO:0045006)
0.0	0.1	GO:0060325	face morphogenesis(GO:0060325)
0.0	0.1	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.0	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.1	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.0	0.0	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.1	GO:0070245	positive regulation of thymocyte apoptotic process(GO:0070245)
0.0	0.1	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.0	GO:0021797	forebrain anterior/posterior pattern specification(GO:0021797)
0.0	0.1	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.0	GO:0044314	protein K27-linked ubiquitination(GO:0044314)
0.0	0.0	GO:0018206	peptidyl-methionine modification(GO:0018206)
0.0	0.0	GO:0060539	diaphragm development(GO:0060539)
0.0	0.0	GO:0071542	dopaminergic neuron differentiation(GO:0071542)
0.0	0.1	GO:0046885	regulation of hormone biosynthetic process(GO:0046885)
0.0	0.0	GO:0006007	glucose catabolic process(GO:0006007)
0.0	0.2	GO:0006378	mRNA polyadenylation(GO:0006378)
0.0	0.1	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.0	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.0	GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein(GO:0042511)
0.0	0.0	GO:0016242	negative regulation of macroautophagy(GO:0016242)
0.0	0.1	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.1	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0010591	regulation of lamellipodium assembly(GO:0010591)
0.0	0.0	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.2	GO:0042462	eye photoreceptor cell development(GO:0042462)
0.0	0.1	GO:0007216	G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.1	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.1	GO:0071001	U4/U6 snRNP(GO:0071001)
0.2	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.1	GO:0070062	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.1	GO:0000778	condensed nuclear chromosome kinetochore(GO:0000778)
0.2	GO:0031616	spindle pole centrosome(GO:0031616)
0.1	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.1	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.1	GO:0044462	external encapsulating structure part(GO:0044462)
0.3	GO:0000178	exosome (RNase complex)(GO:0000178)
0.1	GO:0070545	PeBoW complex(GO:0070545)
0.1	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	GO:0031313	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.2	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1	GO:0045283	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	GO:0045298	tubulin complex(GO:0045298)
0.1	GO:0005664	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.2	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	GO:0031262	Ndc80 complex(GO:0031262)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0008174	mRNA methyltransferase activity(GO:0008174)
0.1	0.2	GO:0003896	DNA primase activity(GO:0003896)
0.0	0.2	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.2	GO:0051400	BH domain binding(GO:0051400)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.1	GO:0015194	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.1	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.1	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.1	GO:0001159	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.1	GO:0016421	CoA carboxylase activity(GO:0016421)
0.0	0.1	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0	0.1	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	0.1	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	0.1	GO:0044020	histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0	0.2	GO:0000175	3'-5'-exoribonuclease activity(GO:0000175)
0.0	0.1	GO:0048039	ubiquinone binding(GO:0048039)
0.0	0.1	GO:0032453	histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0	0.3	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.1	GO:0004690	cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0	0.1	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.0	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.1	GO:0035173	histone kinase activity(GO:0035173)
0.0	0.0	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.1	GO:0016832	aldehyde-lyase activity(GO:0016832)
0.0	0.1	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.1	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.0	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.0	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.0	GO:0003910	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.0	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.2	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.0	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.1	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.1	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.1	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.1	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.0	GO:0034187	obsolete apolipoprotein E binding(GO:0034187)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.1	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.0	GO:0032558	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.1	GO:0003711	obsolete transcription elongation regulator activity(GO:0003711)
0.0	0.1	GO:0016783	sulfurtransferase activity(GO:0016783)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.0	0.4	PID ARF 3PATHWAY	Arf1 pathway
0.0	0.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	0.2	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.3	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.0	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.1	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.3	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.2	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.2	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.3	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.3	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.1	REACTOME REGULATED PROTEOLYSIS OF P75NTR	Genes involved in Regulated proteolysis of p75NTR
0.0	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.4	REACTOME MRNA 3 END PROCESSING	Genes involved in mRNA 3'-end processing
0.1	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
0.2	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.2	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.0	REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT	Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.1	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.2	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.2	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.2	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA