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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for HBP1

Z-value: 1.13

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Transcription factors associated with HBP1

Gene Symbol	Gene ID	Gene Info
HBP1 Ensembl NCBI GeneCards UniProt	ENSG00000105856.9	HBP1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
HBP1	chr7_106874250_106874401	38032	0.151723	0.39	3.0e-01	Click!
HBP1	chr7_106808610_106808963	620	0.749796	0.34	3.7e-01	Click!
HBP1	chr7_106810018_106810657	119	0.968484	0.28	4.6e-01	Click!
HBP1	chr7_106807796_106808590	1213	0.499467	0.27	4.8e-01	Click!
HBP1	chr7_106874818_106874969	38600	0.150442	0.26	5.1e-01	Click!

Activity of the HBP1 motif across conditions

Conditions sorted by the z-value of the HBP1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr2_163171316_163171467	0.56	IFIH1	interferon induced with helicase C domain 1	3803	0.25
chr19_49661333_49661989	0.53	TRPM4	transient receptor potential cation channel, subfamily M, member 4	562	0.58
chr9_684288_685148	0.50	RP11-130C19.3		837	0.67
chr18_9648789_9648940	0.50	ENSG00000212572	.	30794	0.14
chr3_105120211_105120362	0.49	ALCAM	activated leukocyte cell adhesion molecule	34099	0.25
chr16_11295551_11295900	0.47	RMI2	RecQ mediated genome instability 2	47781	0.08
chr7_194025_194290	0.47	AC093627.12		23	0.96
chr2_113593759_113594336	0.46	IL1B	interleukin 1, beta	36	0.97
chr17_74684871_74685203	0.42	MXRA7	matrix-remodelling associated 7	68	0.94
chr14_78602062_78602325	0.41	ENSG00000199454	.	42071	0.19
chr4_114899439_114899761	0.41	ARSJ	arylsulfatase family, member J	552	0.84
chr3_157154723_157155399	0.37	PTX3	pentraxin 3, long	483	0.86
chr18_47089345_47089666	0.37	LIPG	lipase, endothelial	790	0.6
chr6_154675778_154676172	0.37	IPCEF1	interaction protein for cytohesin exchange factors 1	1894	0.48
chr20_49638752_49638903	0.37	KCNG1	potassium voltage-gated channel, subfamily G, member 1	790	0.62
chr7_155678768_155678919	0.35	ENSG00000221113	.	14258	0.24
chr9_80455109_80455260	0.35	GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	17269	0.29
chr18_7116438_7116788	0.35	LAMA1	laminin, alpha 1	1200	0.55
chr11_65083293_65083503	0.34	CDC42EP2	CDC42 effector protein (Rho GTPase binding) 2	1109	0.37
chr2_98703049_98703523	0.34	VWA3B	von Willebrand factor A domain containing 3B	309	0.94
chr2_71115848_71116159	0.33	VAX2	ventral anterior homeobox 2	11717	0.13
chr9_132168981_132169132	0.33	ENSG00000242281	.	36316	0.16
chr5_14265991_14266171	0.33	TRIO	trio Rho guanine nucleotide exchange factor	25005	0.28
chr3_5055062_5055354	0.30	BHLHE40-AS1	BHLHE40 antisense RNA 1	33562	0.15
chr6_24743062_24743323	0.30	C6orf62	chromosome 6 open reading frame 62	22128	0.12
chr8_9472125_9472276	0.30	TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	39683	0.18
chr10_95239483_95239707	0.30	MYOF	myoferlin	2356	0.29
chr2_26624476_26625174	0.29	DRC1	dynein regulatory complex subunit 1 homolog (Chlamydomonas)	41	0.98
chr3_11755297_11755448	0.29	VGLL4	vestigial like 4 (Drosophila)	3361	0.34
chr7_93694115_93694266	0.29	BET1	Bet1 golgi vesicular membrane trafficking protein	60496	0.13
chr13_76217437_76217800	0.29	LMO7	LIM domain 7	7159	0.18
chr7_113996777_113996928	0.28	FOXP2	forkhead box P2	57477	0.15
chr5_62219537_62219688	0.28	LRRC70	leucine rich repeat containing 70	344910	0.01
chr9_111251929_111252080	0.28	ENSG00000222512	.	130795	0.06
chr18_52274836_52275204	0.28	DYNAP	dynactin associated protein	16630	0.28
chr10_21688030_21688514	0.28	ENSG00000207264	.	77382	0.08
chr22_38139385_38139536	0.28	TRIOBP	TRIO and F-actin binding protein	2775	0.17
chr21_39288370_39288729	0.28	KCNJ6	potassium inwardly-rectifying channel, subfamily J, member 6	200	0.96
chr17_7944787_7945045	0.28	ALOX15B	arachidonate 15-lipoxygenase, type B	2442	0.16
chr1_85215722_85215873	0.27	ENSG00000251899	.	43085	0.15
chr4_85886471_85886934	0.27	WDFY3	WD repeat and FYVE domain containing 3	801	0.75
chr8_48770878_48771029	0.27	ENSG00000211562	.	31666	0.17
chr9_12859535_12860149	0.27	ENSG00000222658	.	25478	0.2
chr18_45494721_45494993	0.27	SMAD2	SMAD family member 2	37342	0.19
chr2_213793817_213793968	0.27	ENSG00000266354	.	2911	0.39
chr15_34500911_34501100	0.27	KATNBL1	katanin p80 subunit B-like 1	1207	0.43
chr5_145318270_145318548	0.27	SH3RF2	SH3 domain containing ring finger 2	969	0.66
chr1_153584096_153584410	0.27	S100A16	S100 calcium binding protein A16	1306	0.22
chr9_39816869_39817104	0.27	SPATA31A2	SPATA31 subfamily A, member 2	67989	0.13
chr6_141587373_141587724	0.27	ENSG00000222764	.	220001	0.02
chr19_8633826_8634145	0.27	MYO1F	myosin IF	8337	0.12
chr17_37301005_37301156	0.27	PLXDC1	plexin domain containing 1	6822	0.14
chr1_16647953_16648232	0.27	FBXO42	F-box protein 42	30857	0.12
chr9_39287616_39287852	0.26	CNTNAP3	contactin associated protein-like 3	358	0.92
chr5_177541606_177541785	0.26	N4BP3	NEDD4 binding protein 3	1251	0.43
chr7_96971795_96971946	0.26	ENSG00000221192	.	50962	0.18
chr5_141706853_141707016	0.26	AC005592.2		2071	0.33
chr4_153770751_153770902	0.26	ENSG00000252375	.	51292	0.13
chr6_3238151_3238302	0.25	PSMG4	proteasome (prosome, macropain) assembly chaperone 4	6185	0.19
chr17_39196389_39196540	0.25	KRTAP1-1	keratin associated protein 1-1	1249	0.19
chr1_16125825_16125998	0.25	FBLIM1	filamin binding LIM protein 1	34463	0.09
chr3_174485599_174485896	0.25	NAALADL2	N-acetylated alpha-linked acidic dipeptidase-like 2	91323	0.1
chr20_11871067_11871503	0.25	BTBD3	BTB (POZ) domain containing 3	86	0.98
chr20_38245634_38245785	0.25	ENSG00000241840	.	264307	0.02
chr5_156921339_156921490	0.25	ADAM19	ADAM metallopeptidase domain 19	8416	0.17
chr4_100814684_100815546	0.25	LAMTOR3	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3	418	0.86
chr20_14900281_14900452	0.24	MACROD2-AS1	MACROD2 antisense RNA 1	9766	0.23
chr2_37589065_37589216	0.24	QPCT	glutaminyl-peptide cyclotransferase	6284	0.2
chr19_45147190_45148055	0.24	PVR	poliovirus receptor	225	0.9
chr2_161265827_161265978	0.24	RBMS1	RNA binding motif, single stranded interacting protein 1	782	0.57
chr4_40843301_40843452	0.24	APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	1157	0.46
chr1_97025244_97025565	0.24	ENSG00000241992	.	23361	0.27
chr1_38941740_38942113	0.24	ENSG00000200796	.	79595	0.11
chr1_116470870_116471021	0.24	SLC22A15	solute carrier family 22, member 15	48174	0.15
chr7_41740779_41741576	0.24	INHBA	inhibin, beta A	970	0.56
chr15_70393365_70393548	0.23	TLE3	transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)	2941	0.32
chr3_188599632_188599783	0.23	TPRG1	tumor protein p63 regulated 1	65296	0.14
chr13_104713968_104714119	0.23	SLC10A2	solute carrier family 10 (sodium/bile acid cotransporter), member 2	994847	0.0
chr9_137393023_137393337	0.23	RXRA	retinoid X receptor, alpha	94752	0.07
chr6_108886554_108887901	0.23	FOXO3	forkhead box O3	5158	0.32
chr4_177931083_177931234	0.23	ENSG00000222859	.	171438	0.03
chr22_44844083_44844234	0.23	LDOC1L	leucine zipper, down-regulated in cancer 1-like	50020	0.16
chr9_80539592_80539743	0.23	GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	101752	0.08
chr14_54430258_54430823	0.23	BMP4	bone morphogenetic protein 4	5061	0.28
chr6_77745416_77745567	0.23	HTR1B	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	427999	0.01
chr12_78334342_78334902	0.22	NAV3	neuron navigator 3	25434	0.27
chr1_178067294_178067727	0.22	RASAL2	RAS protein activator like 2	4234	0.36
chr9_43685064_43685767	0.22	CNTNAP3B	contactin associated protein-like 3B	505	0.86
chr3_14644766_14644917	0.22	AC090952.5		46098	0.13
chr1_94071277_94071503	0.22	BCAR3	breast cancer anti-estrogen resistance 3	8264	0.21
chr19_18287388_18287660	0.22	IFI30	interferon, gamma-inducible protein 30	3047	0.14
chr5_161768104_161768255	0.22	ENSG00000201474	.	136718	0.05
chr7_7223417_7223573	0.22	C1GALT1	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1	1249	0.52
chr1_85929812_85930054	0.22	DDAH1	dimethylarginine dimethylaminohydrolase 1	334	0.91
chr18_10787530_10787681	0.22	PIEZO2	piezo-type mechanosensitive ion channel component 2	465	0.88
chr1_179109732_179109883	0.22	ABL2	c-abl oncogene 2, non-receptor tyrosine kinase	2372	0.31
chr4_152462150_152462592	0.22	FAM160A1	family with sequence similarity 160, member A1	8207	0.21
chr3_128712183_128712559	0.22	KIAA1257	KIAA1257	548	0.71
chr9_41432727_41433091	0.22	SPATA31A5	SPATA31 subfamily A, member 5	67770	0.13
chr2_161253806_161254194	0.21	ENSG00000252465	.	521	0.8
chr2_36589107_36589258	0.21	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	5568	0.33
chrX_143576959_143577110	0.21	ENSG00000201912	.	561594	0.0
chr2_219269994_219270145	0.21	ENSG00000199121	.	2700	0.14
chr15_72489601_72489809	0.21	GRAMD2	GRAM domain containing 2	421	0.81
chr16_10174074_10174418	0.21	RP11-895K13.2		46705	0.18
chr6_17394327_17394802	0.21	CAP2	CAP, adenylate cyclase-associated protein, 2 (yeast)	621	0.83
chr8_134742646_134742797	0.21	ENSG00000212273	.	85753	0.11
chr7_51101841_51102176	0.21	RP4-724E13.2		16848	0.28
chr20_60163701_60163894	0.21	CDH4	cadherin 4, type 1, R-cadherin (retinal)	11037	0.3
chr3_47584632_47584783	0.21	ENSG00000266443	.	3117	0.18
chr3_31931620_31931771	0.21	OSBPL10	oxysterol binding protein-like 10	60098	0.13
chr20_17553764_17553929	0.20	DSTN	destrin (actin depolymerizing factor)	3119	0.21
chr10_126752255_126752406	0.20	ENSG00000264572	.	30891	0.18
chr19_51874762_51874926	0.20	NKG7	natural killer cell group 7 sequence	813	0.34
chr20_47404517_47404913	0.20	PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	39705	0.18
chr8_23399467_23399639	0.20	SLC25A37	solute carrier family 25 (mitochondrial iron transporter), member 37	12980	0.16
chr6_83107092_83107769	0.20	TPBG	trophoblast glycoprotein	33469	0.24
chr1_61550208_61550359	0.20	ENSG00000263380	.	1081	0.48
chr1_155196952_155197285	0.20	GBAP1	glucosidase, beta, acid pseudogene 1	96	0.89
chr2_153028407_153028558	0.20	STAM2	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	4024	0.3
chr20_50543681_50543832	0.20	ENSG00000263659	.	13616	0.19
chr3_185815383_185815746	0.20	ETV5	ets variant 5	10769	0.22
chr22_30609203_30609443	0.20	RP3-438O4.4		6225	0.13
chr8_25041394_25041951	0.20	DOCK5	dedicator of cytokinesis 5	566	0.78
chr3_168744436_168744695	0.20	MECOM	MDS1 and EVI1 complex locus	101257	0.09
chr7_130594661_130594812	0.20	ENSG00000226380	.	32438	0.2
chr10_4719979_4720356	0.20	AKR1E2	aldo-keto reductase family 1, member E2	108654	0.07
chr11_76535039_76535190	0.20	RP11-21L23.2		23706	0.13
chr12_101416214_101416365	0.20	RP11-350G24.1		16583	0.22
chr11_119630384_119630535	0.20	CTD-2523D13.2		30166	0.17
chr2_220527194_220527345	0.20	SLC4A3	solute carrier family 4 (anion exchanger), member 3	31417	0.11
chr6_56212766_56212917	0.20	RP3-445N2.1		15926	0.24
chr7_34026746_34026942	0.20	BMPER	BMP binding endothelial regulator	81699	0.11
chr7_18549761_18549974	0.20	HDAC9	histone deacetylase 9	931	0.71
chr16_53243110_53243293	0.20	CHD9	chromodomain helicase DNA binding protein 9	838	0.65
chr2_150998838_150998989	0.19	RND3	Rho family GTPase 3	342983	0.01
chr3_175150553_175150931	0.19	ENSG00000199792	.	35605	0.2
chr20_57602733_57603209	0.19	ATP5E	ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit	4376	0.17
chr2_112456971_112457256	0.19	ENSG00000266063	.	71598	0.12
chr9_68409245_68409396	0.19	ENSG00000207277	.	396	0.88
chr2_237780655_237780806	0.19	ENSG00000202341	.	143218	0.04
chr9_133822496_133822647	0.19	FIBCD1	fibrinogen C domain containing 1	8044	0.18
chr9_116384910_116385169	0.19	RGS3	regulator of G-protein signaling 3	29273	0.19
chr21_36216765_36216916	0.19	RUNX1	runt-related transcription factor 1	42640	0.19
chr2_74374273_74375067	0.19	BOLA3	bolA family member 3	362	0.54
chr3_32464050_32464201	0.19	CMTM7	CKLF-like MARVEL transmembrane domain containing 7	30594	0.19
chr22_22216534_22216685	0.19	MAPK1	mitogen-activated protein kinase 1	5121	0.18
chr4_105890617_105890768	0.19	ENSG00000251906	.	5127	0.33
chr11_66823772_66824268	0.19	RHOD	ras homolog family member D	269	0.9
chr11_46935807_46936022	0.19	LRP4	low density lipoprotein receptor-related protein 4	4259	0.21
chr15_56351412_56351563	0.19	ENSG00000239703	.	29308	0.2
chr7_56101285_56102227	0.19	PSPH	phosphoserine phosphatase	93	0.95
chr1_26680354_26680505	0.19	AIM1L	absent in melanoma 1-like	192	0.9
chr3_167814440_167814591	0.19	GOLIM4	golgi integral membrane protein 4	752	0.79
chr13_31272137_31272539	0.19	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	37307	0.19
chr8_11721948_11722219	0.19	CTSB	cathepsin B	2106	0.27
chr17_79007421_79007691	0.19	BAIAP2	BAI1-associated protein 2	1394	0.31
chr4_105982764_105983024	0.19	ENSG00000252136	.	44250	0.17
chr5_175116482_175116633	0.18	HRH2	histamine receptor H2	8093	0.21
chr9_123476537_123476776	0.18	MEGF9	multiple EGF-like-domains 9	44	0.98
chr17_62257398_62257549	0.18	TEX2	testis expressed 2	32606	0.13
chr6_148513736_148514010	0.18	SASH1	SAM and SH3 domain containing 1	79567	0.1
chr3_156346028_156346179	0.18	TIPARP-AS1	TIPARP antisense RNA 1	44556	0.14
chr8_22932847_22932998	0.18	RP11-875O11.3		921	0.44
chr8_107059298_107059449	0.18	ENSG00000251003	.	13298	0.29
chr3_48470007_48470158	0.18	PLXNB1	plexin B1	790	0.43
chr22_18255963_18256689	0.18	BID	BH3 interacting domain death agonist	456	0.82
chr2_38144201_38144470	0.18	RMDN2	regulator of microtubule dynamics 2	5995	0.3
chr8_119121667_119121966	0.18	EXT1	exostosin glycosyltransferase 1	837	0.77
chr2_71127433_71128165	0.18	VAX2	ventral anterior homeobox 2	79	0.96
chr4_77131865_77132211	0.18	SCARB2	scavenger receptor class B, member 2	2718	0.22
chr12_81489356_81489507	0.18	ACSS3	acyl-CoA synthetase short-chain family member 3	17595	0.21
chr1_94711175_94711488	0.18	ARHGAP29	Rho GTPase activating protein 29	8142	0.25
chr8_128699254_128699540	0.18	MYC	v-myc avian myelocytomatosis viral oncogene homolog	48283	0.18
chr1_186156970_186157465	0.18	GS1-174L6.4		10783	0.22
chr2_113998091_113998347	0.18	RP11-65I12.1		88	0.94
chr7_143072173_143072546	0.18	AC093673.5		5229	0.12
chr6_27205685_27206711	0.18	PRSS16	protease, serine, 16 (thymus)	9282	0.19
chr5_133802242_133802478	0.18	ENSG00000207222	.	33615	0.12
chr9_123657022_123657322	0.18	PHF19	PHD finger protein 19	17566	0.17
chr14_94856045_94856196	0.17	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	831	0.62
chr1_182993880_182994112	0.17	LAMC1	laminin, gamma 1 (formerly LAMB2)	1401	0.44
chr10_7806287_7806438	0.17	KIN	KIN, antigenic determinant of recA protein homolog (mouse)	23582	0.17
chr1_178064247_178064419	0.17	RASAL2	RAS protein activator like 2	1057	0.69
chr10_52750817_52751095	0.17	PRKG1	protein kinase, cGMP-dependent, type I	11	0.99
chr16_28228037_28228188	0.17	XPO6	exportin 6	4871	0.21
chr13_77148711_77148862	0.17	KCTD12	potassium channel tetramerization domain containing 12	311739	0.01
chr7_41739624_41740047	0.17	INHBA	inhibin, beta A	372	0.87
chr10_23734346_23734497	0.17	OTUD1	OTU domain containing 1	6223	0.23
chr13_40974473_40974748	0.17	ENSG00000252812	.	6967	0.31
chr10_79470838_79471281	0.17	ENSG00000199664	.	65754	0.1
chr2_851043_851194	0.17	AC113607.3		65692	0.12
chr10_37761163_37761314	0.17	MTRNR2L7	MT-RNR2-like 7	130621	0.05
chr1_183134527_183134678	0.17	LAMC2	laminin, gamma 2	20771	0.19
chr6_5671739_5671953	0.17	RP1-256G22.2		23659	0.27
chr1_110576828_110577139	0.17	STRIP1	striatin interacting protein 1	255	0.89
chr5_64775674_64775852	0.17	ADAMTS6	ADAM metallopeptidase with thrombospondin type 1 motif, 6	1941	0.4
chr12_116893318_116893532	0.17	ENSG00000264037	.	27302	0.23
chr7_36195246_36195841	0.17	EEPD1	endonuclease/exonuclease/phosphatase family domain containing 1	2666	0.32
chr2_71694242_71694483	0.17	DYSF	dysferlin	530	0.84

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HBP1

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0010193	response to ozone(GO:0010193)
0.1	0.3	GO:0036336	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.1	0.3	GO:0045578	negative regulation of B cell differentiation(GO:0045578)
0.1	0.3	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1	0.2	GO:0070933	histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.1	0.2	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1	0.3	GO:0030859	polarized epithelial cell differentiation(GO:0030859)
0.1	0.2	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.3	GO:0001878	response to yeast(GO:0001878)
0.1	0.1	GO:0008615	pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0	0.2	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.1	GO:0002540	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.1	GO:0051573	negative regulation of histone H3-K9 methylation(GO:0051573)
0.0	0.1	GO:0070100	Roundabout signaling pathway(GO:0035385) regulation of chemokine-mediated signaling pathway(GO:0070099) negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.0	0.1	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.1	GO:0032632	interleukin-3 production(GO:0032632)
0.0	0.2	GO:0055091	phospholipid homeostasis(GO:0055091)
0.0	0.2	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0	0.1	GO:0071428	rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.0	0.3	GO:0000052	citrulline metabolic process(GO:0000052)
0.0	0.1	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.0	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.0	0.1	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.0	0.1	GO:0043497	regulation of protein heterodimerization activity(GO:0043497)
0.0	0.1	GO:1903312	negative regulation of mRNA processing(GO:0050686) negative regulation of mRNA metabolic process(GO:1903312)
0.0	0.2	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.1	GO:0018243	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0009173	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.1	GO:0022030	cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0	0.1	GO:0050932	regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0	0.1	GO:0048263	determination of dorsal identity(GO:0048263)
0.0	0.1	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.0	GO:0060686	negative regulation of prostatic bud formation(GO:0060686)
0.0	0.1	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.1	GO:0060766	negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0	0.1	GO:0045542	positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0	0.1	GO:0051014	actin filament severing(GO:0051014)
0.0	0.2	GO:0015671	oxygen transport(GO:0015671)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.1	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.1	GO:0043302	positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of leukocyte degranulation(GO:0043302) positive regulation of mast cell degranulation(GO:0043306)
0.0	0.0	GO:0033084	regulation of immature T cell proliferation in thymus(GO:0033084)
0.0	0.1	GO:0022038	corpus callosum development(GO:0022038)
0.0	0.1	GO:0097709	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0	0.1	GO:0022617	extracellular matrix disassembly(GO:0022617)
0.0	0.1	GO:0031269	pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.3	GO:0002021	response to dietary excess(GO:0002021)
0.0	0.1	GO:0070141	response to UV-A(GO:0070141)
0.0	0.0	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.3	GO:0071230	cellular response to amino acid stimulus(GO:0071230)
0.0	0.1	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.1	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:0051877	pigment granule aggregation in cell center(GO:0051877)
0.0	0.2	GO:0034260	negative regulation of GTPase activity(GO:0034260)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.2	GO:0048048	embryonic eye morphogenesis(GO:0048048)
0.0	0.1	GO:0070561	vitamin D receptor signaling pathway(GO:0070561)
0.0	0.1	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.0	0.1	GO:0030853	negative regulation of granulocyte differentiation(GO:0030853)
0.0	0.1	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0	0.1	GO:1904358	positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.2	GO:0002089	lens morphogenesis in camera-type eye(GO:0002089)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.0	GO:0050703	interleukin-1 alpha secretion(GO:0050703)
0.0	0.1	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.2	GO:0010288	response to lead ion(GO:0010288)
0.0	0.1	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.1	GO:0034214	protein hexamerization(GO:0034214)
0.0	0.0	GO:0008049	male courtship behavior(GO:0008049)
0.0	0.0	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.1	GO:0030174	regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0	0.1	GO:0060765	regulation of androgen receptor signaling pathway(GO:0060765)
0.0	0.1	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.0	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.0	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.1	GO:0043248	proteasome assembly(GO:0043248)
0.0	0.1	GO:0034312	diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.0	0.0	GO:2000644	regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) regulation of receptor catabolic process(GO:2000644)
0.0	0.1	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.0	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.0	GO:0032610	interleukin-1 alpha production(GO:0032610)
0.0	0.0	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.1	GO:0090399	replicative senescence(GO:0090399)
0.0	0.1	GO:0008045	motor neuron axon guidance(GO:0008045)
0.0	0.0	GO:0010996	response to auditory stimulus(GO:0010996)
0.0	0.1	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.0	GO:0010800	positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0	0.1	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0	0.0	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.2	GO:0051602	response to electrical stimulus(GO:0051602)
0.0	0.1	GO:0032876	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.0	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.1	GO:1904031	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0	0.1	GO:0045749	obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0	0.0	GO:0034086	maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.0	0.0	GO:0030091	protein repair(GO:0030091)
0.0	0.2	GO:0007190	activation of adenylate cyclase activity(GO:0007190)
0.0	0.0	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0	0.1	GO:0048261	negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0	0.0	GO:0033603	positive regulation of dopamine secretion(GO:0033603)
0.0	0.1	GO:0060325	face morphogenesis(GO:0060325)
0.0	0.1	GO:0070306	lens fiber cell differentiation(GO:0070306)
0.0	0.0	GO:0045759	negative regulation of action potential(GO:0045759)
0.0	0.1	GO:0046339	diacylglycerol metabolic process(GO:0046339)
0.0	0.0	GO:0045990	carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015)
0.0	0.0	GO:0046022	regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.1	GO:0043558	regulation of translational initiation in response to stress(GO:0043558)
0.0	0.1	GO:0046132	pyrimidine ribonucleoside biosynthetic process(GO:0046132)
0.0	0.0	GO:0043457	regulation of cellular respiration(GO:0043457)
0.0	0.2	GO:0001937	negative regulation of endothelial cell proliferation(GO:0001937)
0.0	0.0	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.0	GO:0061043	vascular wound healing(GO:0061042) regulation of vascular wound healing(GO:0061043)
0.0	0.0	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.0	GO:0008218	bioluminescence(GO:0008218)
0.0	0.0	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.0	GO:0046426	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.1	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.0	GO:0097061	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine development(GO:0060998) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.0	GO:0032506	cytokinetic process(GO:0032506)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1	0.2	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.3	GO:0005606	laminin-1 complex(GO:0005606)
0.0	0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.1	GO:0030992	intraciliary transport particle B(GO:0030992)
0.0	0.1	GO:0044462	external encapsulating structure part(GO:0044462)
0.0	0.2	GO:0030128	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.1	GO:0000125	PCAF complex(GO:0000125)
0.0	0.1	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.1	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.0	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.2	GO:0031941	filamentous actin(GO:0031941)
0.0	0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.1	GO:0051233	spindle midzone(GO:0051233)
0.0	0.1	GO:0005832	chaperonin-containing T-complex(GO:0005832)
0.0	0.0	GO:0043256	laminin complex(GO:0043256)
0.0	0.0	GO:0032449	CBM complex(GO:0032449)
0.0	0.0	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.0	0.1	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.0	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	0.0	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.0	0.0	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.3	GO:0005776	autophagosome(GO:0005776)
0.0	0.0	GO:0071256	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	0.1	GO:0000796	condensin complex(GO:0000796)
0.0	0.1	GO:0005721	pericentric heterochromatin(GO:0005721)
0.0	0.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.1	0.5	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.1	0.3	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1	0.2	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1	0.2	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.1	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.1	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.1	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.2	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.1	GO:0035252	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.3	GO:0030247	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.2	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.1	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.2	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.0	GO:0050698	proteoglycan sulfotransferase activity(GO:0050698)
0.0	0.1	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.1	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.3	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.1	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.1	GO:0004346	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.2	GO:0032041	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0	0.3	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.1	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.2	GO:0005123	death receptor binding(GO:0005123)
0.0	0.1	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.3	GO:0005227	calcium activated cation channel activity(GO:0005227)
0.0	0.1	GO:0019211	phosphatase activator activity(GO:0019211)
0.0	0.0	GO:0045545	syndecan binding(GO:0045545)
0.0	0.2	GO:0043498	obsolete cell surface binding(GO:0043498)
0.0	0.2	GO:0017134	fibroblast growth factor binding(GO:0017134)
0.0	0.1	GO:0008503	benzodiazepine receptor activity(GO:0008503)
0.0	0.1	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.1	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.0	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.2	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.0	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.0	GO:0045159	myosin II binding(GO:0045159)
0.0	0.0	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.0	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.1	GO:0044548	S100 protein binding(GO:0044548)
0.0	0.1	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.0	GO:0016454	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.1	GO:0099604	calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.1	GO:0004583	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.0	0.0	GO:0004525	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0	0.2	GO:0031490	chromatin DNA binding(GO:0031490)
0.0	0.0	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.0	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.1	GO:0043015	gamma-tubulin binding(GO:0043015)
0.0	0.0	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.0	GO:0008061	chitin binding(GO:0008061)
0.0	0.3	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.0	0.0	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.0	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.0	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.1	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.1	GO:0016165	linoleate 13S-lipoxygenase activity(GO:0016165)
0.0	0.2	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.0	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.0	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.0	GO:0055077	gap junction hemi-channel activity(GO:0055077)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.3	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.4	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.2	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.2	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.4	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.2	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.5	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.3	PID ALK1 PATHWAY	ALK1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.0	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.3	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.3	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.3	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.6	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.3	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.1	REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0	REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.3	REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	Genes involved in Energy dependent regulation of mTOR by LKB1-AMPK
0.6	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.2	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.1	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.1	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.1	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.2	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.4	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates