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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for HDX

Z-value: 0.83

Motif logo

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Transcription factors associated with HDX

Gene Symbol Gene ID Gene Info
HDX
ENSG00000165259.9 HDX

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
HDXchrX_83756622_837567976900.4823300.511.6e-01Click!
HDXchrX_83838309_83838460808970.105276-0.402.9e-01Click!
HDXchrX_83619155_836193061381690.0472440.393.1e-01Click!
HDXchrX_83756396_837565479280.445126-0.284.7e-01Click!
HDXchrX_83756867_837572393460.5480160.108.0e-01Click!

Activity of the HDX motif across conditions

Conditions sorted by the z-value of the HDX motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr18_77380232_77380598 0.36 CTDP1
 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
 59386
 0.13
chr10_121579974_121580125 0.29 INPP5F
 inositol polyphosphate-5-phosphatase F
 1821
 0.39
chr1_97004381_97004538 0.28 ENSG00000241992
 .
 44306
 0.2
chr4_160169630_160170007 0.27 RAPGEF2
 Rap guanine nucleotide exchange factor (GEF) 2
 18215
 0.23
chr2_144339822_144340188 0.25 RP11-570L15.2
10331
 0.21
chr21_17951850_17952023 0.25 ENSG00000207863
 .
 10621
 0.23
chr8_63998343_63998943 0.24 TTPA
 tocopherol (alpha) transfer protein
 31
 0.98
chr7_42377692_42377843 0.23 GLI3
 GLI family zinc finger 3
 101109
 0.09
chr4_154178869_154179109 0.22 TRIM2
 tripartite motif containing 2
 427
 0.82
chr17_59235574_59235725 0.22 RP11-136H19.1
22324
 0.2
chr5_107634116_107634267 0.22 FBXL17
 F-box and leucine-rich repeat protein 17
 69464
 0.14
chr18_34273309_34273594 0.21 FHOD3
 formin homology 2 domain containing 3
 25069
 0.22
chr19_7581346_7582140 0.21 ZNF358
 zinc finger protein 358
 739
 0.45
chr10_54326536_54326691 0.21 RP11-556E13.1
5748
 0.34
chr12_62529544_62529695 0.20 FAM19A2
 family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
 198
 0.95
chr2_155312032_155312187 0.20 AC009227.2
1841
 0.42
chr8_89338531_89338740 0.20 RP11-586K2.1
430
 0.76
chr8_116675821_116675972 0.20 TRPS1
 trichorhinophalangeal syndrome I
 1991
 0.5
chr3_21686525_21686676 0.20 ZNF385D-AS1
 ZNF385D antisense RNA 1
 102292
 0.08
chrY_7229387_7229538 0.19 ENSG00000252155
 .
 17251
 0.18
chr17_80970638_80970845 0.19 RP11-1197K16.2
31783
 0.15
chr12_78334108_78334310 0.19 NAV3
 neuron navigator 3
 25847
 0.27
chr10_78733590_78733741 0.18 RP11-443A13.5
34799
 0.21
chr2_72438706_72438857 0.18 CYP26B1
 cytochrome P450, family 26, subfamily B, polypeptide 1
 63614
 0.16
chr1_156098075_156098411 0.18 LMNA
 lamin A/C
 1649
 0.24
chr5_103680813_103681290 0.18 ENSG00000239808
 .
 84524
 0.11
chr13_74899197_74899360 0.18 ENSG00000206617
 .
 35927
 0.21
chrX_45634159_45634477 0.18 ENSG00000207725
 .
 27788
 0.21
chr6_13463704_13463855 0.18 AL583828.1
22636
 0.15
chr15_100348989_100349200 0.18 CTD-2054N24.2
 Uncharacterized protein
 901
 0.5
chr2_164592268_164592669 0.17 FIGN
 fidgetin
 49
 0.99
chr1_8194377_8194540 0.17 ENSG00000200975
 .
 72199
 0.1
chr9_20873253_20873668 0.17 FOCAD
 focadhesin
 53167
 0.14
chr16_64944591_64944811 0.17 CDH11
 cadherin 11, type 2, OB-cadherin (osteoblast)
 148880
 0.05
chr9_130614412_130614666 0.17 ENG
 endoglin
 2376
 0.13
chr12_88811798_88812120 0.16 ENSG00000199245
 .
 12260
 0.3
chr2_8818889_8820001 0.16 AC011747.7
259
 0.7
chr12_15874929_15875080 0.16 EPS8
 epidermal growth factor receptor pathway substrate 8
 6195
 0.28
chr14_64887783_64887949 0.16 CTD-2555O16.4
21090
 0.12
chr1_107805441_107805592 0.16 NTNG1
 netrin G1
 114300
 0.07
chr13_93105495_93105646 0.16 GPC5-IT1
 GPC5 intronic transcript 1 (non-protein coding)
 31289
 0.2
chr6_12761420_12761571 0.16 ENSG00000223291
 .
 7588
 0.25
chr14_27067998_27068288 0.16 NOVA1-AS1
 NOVA1 antisense RNA 1 (head to head)
 525
 0.68
chr1_178995460_178996425 0.16 FAM20B
 family with sequence similarity 20, member B
 911
 0.66
chr10_133775388_133775627 0.16 BNIP3
 BCL2/adenovirus E1B 19kDa interacting protein 3
 19920
 0.21
chr2_223908392_223908543 0.16 KCNE4
 potassium voltage-gated channel, Isk-related family, member 4
 8065
 0.28
chr9_16628546_16628697 0.16 RP11-62F24.1
2947
 0.36
chr10_25008347_25008498 0.16 ARHGAP21
 Rho GTPase activating protein 21
 2373
 0.41
chr1_232803140_232803291 0.16 ENSG00000238382
 .
 32735
 0.22
chr6_156979574_156979742 0.16 ARID1B
 AT rich interactive domain 1B (SWI1-like)
 119405
 0.06
chr1_98515040_98515403 0.16 ENSG00000225206
 .
 3494
 0.38
chr18_22928819_22929051 0.15 ZNF521
 zinc finger protein 521
 2222
 0.42
chr4_19731588_19731739 0.15 SLIT2
 slit homolog 2 (Drosophila)
 523220
 0.0
chr8_24366846_24366997 0.15 RP11-561E1.1
5180
 0.24
chr5_140797768_140798225 0.15 PCDHGB7
 protocadherin gamma subfamily B, 7
 569
 0.45
chr7_55167054_55167326 0.15 EGFR
 epidermal growth factor receptor
 10226
 0.29
chr18_55447994_55448240 0.15 ATP8B1
 ATPase, aminophospholipid transporter, class I, type 8B, member 1
 22210
 0.18
chr18_77378799_77378950 0.15 CTDP1
 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
 60927
 0.13
chr4_162286727_162286878 0.15 RP11-234O6.2
13303
 0.32
chr16_60157481_60157632 0.15 ENSG00000265167
 .
 306081
 0.01
chr9_97666762_97667035 0.15 RP11-49O14.2
4187
 0.23
chr14_71372031_71372182 0.15 PCNX
 pecanex homolog (Drosophila)
 2016
 0.46
chr3_119219012_119219163 0.15 TIMMDC1
 translocase of inner mitochondrial membrane domain containing 1
 1659
 0.33
chr2_11076773_11076924 0.15 KCNF1
 potassium voltage-gated channel, subfamily F, member 1
 24785
 0.2
chr2_106912824_106912975 0.15 PLGLA
 plasminogen-like A (pseudogene)
 85663
 0.09
chr2_200025621_200025772 0.15 ENSG00000238698
 .
 30086
 0.25
chr1_90018677_90018828 0.15 LRRC8B
 leucine rich repeat containing 8 family, member B
 15048
 0.22
chr12_91430839_91430990 0.15 KERA
 keratocan
 20846
 0.2
chr10_15126962_15127123 0.14 ACBD7
 acyl-CoA binding domain containing 7
 3733
 0.19
chr1_119524620_119524878 0.14 TBX15
 T-box 15
 5679
 0.29
chr17_13265618_13265967 0.14 ENSG00000266115
 .
 137853
 0.05
chr12_91504528_91504679 0.14 LUM
 lumican
 1005
 0.61
chr4_41157747_41157945 0.14 ENSG00000207198
 .
 41887
 0.14
chr18_51886872_51887023 0.14 C18orf54
 chromosome 18 open reading frame 54
 1992
 0.33
chr1_200212018_200212550 0.14 ENSG00000221403
 .
 98322
 0.08
chr3_178015611_178015762 0.14 KCNMB2
 potassium large conductance calcium-activated channel, subfamily M, beta member 2
 24966
 0.26
chr2_180214031_180214182 0.14 SESTD1
 SEC14 and spectrin domains 1
 84589
 0.1
chr6_35182117_35182910 0.14 SCUBE3
 signal peptide, CUB domain, EGF-like 3
 317
 0.9
chr12_132316032_132316383 0.14 MMP17
 matrix metallopeptidase 17 (membrane-inserted)
 3122
 0.22
chr4_17325894_17326097 0.14 ENSG00000206780
 .
 3490
 0.36
chr13_45145551_45145847 0.14 TSC22D1
 TSC22 domain family, member 1
 4693
 0.31
chr16_86619409_86619937 0.14 FOXL1
 forkhead box L1
 7558
 0.18
chr4_148024489_148024820 0.13 TTC29
 tetratricopeptide repeat domain 29
 157620
 0.04
chr2_101359270_101359474 0.13 NPAS2
 neuronal PAS domain protein 2
 77242
 0.09
chr3_88191761_88191912 0.13 ZNF654
 zinc finger protein 654
 3582
 0.23
chr6_56818301_56819485 0.13 DST
 dystonin
 492
 0.63
chr17_17862779_17863058 0.13 TOM1L2
 target of myb1-like 2 (chicken)
 12793
 0.15
chr20_52273531_52273682 0.13 ENSG00000238468
 .
 11691
 0.23
chr9_89336989_89337198 0.13 GAS1
 growth arrest-specific 1
 225011
 0.02
chr17_15209661_15209932 0.13 ENSG00000200437
 .
 4866
 0.18
chr11_114398277_114398428 0.13 ENSG00000238724
 .
 501
 0.77
chr6_157297907_157298141 0.13 ARID1B
 AT rich interactive domain 1B (SWI1-like)
 75517
 0.12
chr6_155783008_155783159 0.13 NOX3
 NADPH oxidase 3
 6046
 0.32
chr2_212025965_212026310 0.13 ENSG00000199585
 .
 374241
 0.01
chr5_980561_980809 0.13 RP11-661C8.3
 Uncharacterized protein
 1205
 0.39
chr19_31153950_31154101 0.13 ENSG00000223148
 .
 48898
 0.19
chrX_131467583_131467734 0.13 MBNL3
 muscleblind-like splicing regulator 3
 57330
 0.15
chr17_63693222_63693493 0.13 CEP112
 centrosomal protein 112kDa
 53485
 0.17
chr8_126010804_126011981 0.13 SQLE
 squalene epoxidase
 606
 0.56
chr3_159978482_159978633 0.13 RP11-431I8.1
34287
 0.13
chr2_26401607_26402234 0.13 GAREML
 GRB2 associated, regulator of MAPK1-like
 1665
 0.38
chr8_20080573_20080724 0.13 ENSG00000222267
 .
 6642
 0.19
chr2_17484452_17484603 0.13 ENSG00000222842
 .
 180120
 0.03
chr9_91138470_91138621 0.13 NXNL2
 nucleoredoxin-like 2
 11471
 0.29
chr1_84629927_84630112 0.13 PRKACB
 protein kinase, cAMP-dependent, catalytic, beta
 13
 0.99
chr17_37099094_37099245 0.13 RP1-56K13.3
21147
 0.11
chr8_120648373_120648673 0.13 ENPP2
 ectonucleotide pyrophosphatase/phosphodiesterase 2
 2497
 0.38
chr14_33178041_33178192 0.13 AKAP6
 A kinase (PRKA) anchor protein 6
 26941
 0.27
chr2_20098121_20098272 0.12 TTC32
 tetratricopeptide repeat domain 32
 3206
 0.31
chr8_117529471_117529622 0.12 ENSG00000264815
 .
 229958
 0.02
chr12_64580629_64580780 0.12 ENSG00000212298
 .
 17869
 0.15
chr6_148886558_148886709 0.12 ENSG00000223322
 .
 41257
 0.21
chrX_13680096_13680380 0.12 TCEANC
 transcription elongation factor A (SII) N-terminal and central domain containing
 6824
 0.2
chr6_17925089_17925240 0.12 KIF13A
 kinesin family member 13A
 62530
 0.13
chr13_73356894_73357293 0.12 DIS3
 DIS3 mitotic control homolog (S. cerevisiae)
 859
 0.4
chr5_64775674_64775852 0.12 ADAMTS6
 ADAM metallopeptidase with thrombospondin type 1 motif, 6
 1941
 0.4
chr4_175056009_175056160 0.12 FBXO8
 F-box protein 8
 148730
 0.04
chr13_36298655_36298806 0.12 DCLK1
 doublecortin-like kinase 1
 131049
 0.05
chr18_77379773_77379948 0.12 CTDP1
 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
 59941
 0.13
chr2_9778930_9779081 0.12 YWHAQ
 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
 7862
 0.21
chr8_99410632_99410929 0.12 KCNS2
 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2
 28470
 0.18
chr12_21981834_21982050 0.12 RP11-729I10.2
1798
 0.39
chr13_31482253_31482459 0.12 MEDAG
 mesenteric estrogen-dependent adipogenesis
 1513
 0.41
chr10_36783162_36783313 0.12 NAMPTL
 nicotinamide phosphoribosyltransferase-like
 29086
 0.22
chr7_15596833_15597046 0.12 AGMO
 alkylglycerol monooxygenase
 4701
 0.34
chr2_204679921_204680089 0.12 ENSG00000206970
 .
 33245
 0.17
chr16_67203881_67204335 0.12 NOL3
 nucleolar protein 3 (apoptosis repressor with CARD domain)
 51
 0.91
chr1_99731775_99731926 0.12 LPPR4
 Lipid phosphate phosphatase-related protein type 4
 2002
 0.49
chr11_107461958_107462688 0.12 AP000889.3
 HCG2032453; Uncharacterized protein; cDNA FLJ25337 fis, clone TST00714
 148
 0.74
chr8_72777208_72777359 0.12 MSC
 musculin
 20580
 0.17
chr2_75867971_75868176 0.12 ENSG00000239018
 .
 5806
 0.13
chr8_117883179_117883330 0.12 RAD21
 RAD21 homolog (S. pombe)
 3345
 0.19
chr20_61656853_61657255 0.12 BHLHE23
 basic helix-loop-helix family, member e23
 18667
 0.17
chr17_79317268_79317735 0.12 TMEM105
 transmembrane protein 105
 13027
 0.13
chr13_47470589_47471243 0.12 HTR2A
 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
 253
 0.95
chr10_73946584_73946735 0.12 ENSG00000200294
 .
 6043
 0.17
chr7_33111925_33112076 0.12 NT5C3A
 5'-nucleotidase, cytosolic IIIA
 9591
 0.15
chr2_119603311_119603908 0.12 EN1
 engrailed homeobox 1
 1645
 0.51
chr4_152146952_152147499 0.11 SH3D19
 SH3 domain containing 19
 7
 0.98
chr2_39719567_39719774 0.11 AC007246.3
21617
 0.22
chr18_3625070_3625338 0.11 DLGAP1-AS2
 DLGAP1 antisense RNA 2
 21468
 0.14
chr13_36274861_36275012 0.11 NBEA
 neurobeachin
 107793
 0.07
chr12_95177906_95178057 0.11 ENSG00000208038
 .
 50193
 0.17
chr5_158559403_158559554 0.11 EBF1
 early B-cell factor 1
 32709
 0.18
chr12_113709895_113710081 0.11 TPCN1
 two pore segment channel 1
 4735
 0.18
chr8_117456913_117457110 0.11 ENSG00000264815
 .
 157423
 0.04
chr3_174044116_174044267 0.11 NAALADL2
 N-acetylated alpha-linked acidic dipeptidase-like 2
 114586
 0.07
chr4_16198053_16198212 0.11 TAPT1
 transmembrane anterior posterior transformation 1
 5025
 0.22
chr3_193851589_193851867 0.11 HES1
 hes family bHLH transcription factor 1
 2206
 0.28
chr3_28957653_28958300 0.11 ENSG00000238470
 .
 94757
 0.09
chr9_18386232_18386424 0.11 ADAMTSL1
 ADAMTS-like 1
 87564
 0.1
chr6_17868077_17868228 0.11 KIF13A
 kinesin family member 13A
 50721
 0.16
chr18_18944422_18944573 0.11 GREB1L
 growth regulation by estrogen in breast cancer-like
 943
 0.63
chr15_101632383_101632547 0.11 RP11-505E24.2
6194
 0.25
chr13_75940906_75941057 0.11 TBC1D4-AS1
 TBC1D4 antisense RNA 1
 10449
 0.24
chr4_53719384_53719535 0.11 RASL11B
 RAS-like, family 11, member B
 8998
 0.22
chr6_138002128_138002279 0.11 ENSG00000216097
 .
 35882
 0.2
chr2_201331503_201331739 0.11 SPATS2L
 spermatogenesis associated, serine-rich 2-like
 26249
 0.16
chr17_47078770_47079113 0.11 IGF2BP1
 insulin-like growth factor 2 mRNA binding protein 1
 3833
 0.12
chr1_67002413_67002591 0.11 SGIP1
 SH3-domain GRB2-like (endophilin) interacting protein 1
 2537
 0.38
chr8_39965880_39966091 0.11 C8orf4
 chromosome 8 open reading frame 4
 45004
 0.18
chr1_162596970_162597121 0.11 DDR2
 discoidin domain receptor tyrosine kinase 2
 4118
 0.23
chr7_92327286_92327437 0.11 ENSG00000206763
 .
 3767
 0.31
chr14_52348217_52348368 0.11 GNG2
 guanine nucleotide binding protein (G protein), gamma 2
 3982
 0.24
chr4_138452050_138452321 0.11 PCDH18
 protocadherin 18
 1380
 0.62
chr11_132614961_132615112 0.11 OPCML-IT2
 OPCML intronic transcript 2 (non-protein coding)
 114936
 0.07
chr5_152825234_152825385 0.11 GRIA1
 glutamate receptor, ionotropic, AMPA 1
 44797
 0.21
chr8_138161471_138161805 0.11 ENSG00000206678
 .
 44043
 0.22
chr16_54465247_54465407 0.11 ENSG00000264079
 .
 117981
 0.06
chrX_103554920_103555123 0.11 ESX1
 ESX homeobox 1
 55407
 0.15
chr2_11508011_11508277 0.11 ROCK2
 Rho-associated, coiled-coil containing protein kinase 2
 23433
 0.2
chr10_63595192_63595343 0.11 ARID5B
 AT rich interactive domain 5B (MRF1-like)
 65792
 0.13
chr14_55239224_55239463 0.11 SAMD4A
 sterile alpha motif domain containing 4A
 17792
 0.24
chr7_139578044_139578195 0.11 TBXAS1
 thromboxane A synthase 1 (platelet)
 49009
 0.16
chr15_48936207_48936433 0.11 FBN1
 fibrillin 1
 1598
 0.51
chr3_114119404_114119777 0.11 ZBTB20-AS1
 ZBTB20 antisense RNA 1
 13074
 0.21
chr2_27434850_27435940 0.11 SLC5A6
 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
 5
 0.66
chr12_91721216_91721367 0.11 DCN
 decorin
 144391
 0.05
chr3_77562048_77562199 0.11 ROBO2
 roundabout, axon guidance receptor, homolog 2 (Drosophila)
 75809
 0.13
chr20_51658849_51659000 0.11 ENSG00000252629
 .
 20232
 0.22
chr6_157956725_157956898 0.11 ENSG00000266617
 .
 6647
 0.28
chr4_87812935_87814058 0.11 C4orf36
 chromosome 4 open reading frame 36
 52
 0.98
chr6_24283092_24283303 0.10 KAAG1
 kidney associated antigen 1
 73934
 0.09
chr15_36145502_36145653 0.10 ENSG00000265098
 .
 73480
 0.13
chr7_27680791_27681081 0.10 HIBADH
 3-hydroxyisobutyrate dehydrogenase
 6439
 0.28
chr4_169553568_169553728 0.10 PALLD
 palladin, cytoskeletal associated protein
 880
 0.63
chr2_1658470_1658621 0.10 AC144450.1
34660
 0.19
chr8_38316900_38317069 0.10 FGFR1
 fibroblast growth factor receptor 1
 1963
 0.28
chr10_3495258_3495563 0.10 PITRM1
 pitrilysin metallopeptidase 1
 280407
 0.01
chr4_169060384_169060535 0.10 RP11-310I9.1
25977
 0.21
chr9_34654990_34655141 0.10 IL11RA
 interleukin 11 receptor, alpha
 16
 0.94
chr12_70132575_70133879 0.10 RAB3IP
 RAB3A interacting protein
 47
 0.95
chr7_82052951_82053102 0.10 CACNA2D1
 calcium channel, voltage-dependent, alpha 2/delta subunit 1
 20005
 0.29
chr7_111079006_111079157 0.10 IMMP2L
 IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
 46110
 0.2
chr10_711808_711959 0.10 RP11-809C18.5
2385
 0.24
chr7_137026886_137027037 0.10 PTN
 pleiotrophin
 1559
 0.52
chr7_93518213_93518642 0.10 TFPI2
 tissue factor pathway inhibitor 2
 1055
 0.43
chr8_42013507_42013690 0.10 AP3M2
 adaptor-related protein complex 3, mu 2 subunit
 1464
 0.36
chr7_24517307_24517482 0.10 ENSG00000206877
 .
 59557
 0.14
chr1_234879912_234880063 0.10 ENSG00000201638
 .
 93733
 0.08

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of HDX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0070933 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0 0.1 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.0 0.0 GO:2000380 regulation of mesodermal cell fate specification(GO:0042661) regulation of mesoderm development(GO:2000380)
0.0 0.1 GO:0008218 bioluminescence(GO:0008218)
0.0 0.1 GO:0043267 negative regulation of potassium ion transport(GO:0043267)
0.0 0.1 GO:0003308 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0 0.2 GO:1901532 regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0 0.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.1 GO:1900116 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.1 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0 0.1 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.0 0.1 GO:0060437 lung growth(GO:0060437)
0.0 0.1 GO:0060242 contact inhibition(GO:0060242)
0.0 0.1 GO:0006531 aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.0 0.1 GO:0008049 male courtship behavior(GO:0008049)
0.0 0.1 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.0 GO:0003161 cardiac conduction system development(GO:0003161)
0.0 0.0 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.1 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.1 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.1 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.0 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0 0.0 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 0.2 GO:0009268 response to pH(GO:0009268)
0.0 0.0 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.0 0.0 GO:0002072 optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0 0.1 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.0 GO:1903332 regulation of protein folding(GO:1903332)
0.0 0.1 GO:0014029 neural crest formation(GO:0014029) neural crest cell fate commitment(GO:0014034)
0.0 0.0 GO:0070672 response to interleukin-15(GO:0070672)
0.0 0.1 GO:0060997 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0 0.0 GO:0035609 C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0 0.0 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.1 GO:0048703 embryonic viscerocranium morphogenesis(GO:0048703)
0.0 0.1 GO:0006893 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.0 0.0 GO:0060594 mammary gland specification(GO:0060594)
0.0 0.0 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.0 0.0 GO:0016103 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.0 GO:0003207 cardiac chamber formation(GO:0003207) cardiac ventricle formation(GO:0003211)
0.0 0.1 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.0 GO:0048840 otolith development(GO:0048840)
0.0 0.1 GO:0016264 gap junction assembly(GO:0016264)
0.0 0.0 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.0 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.0 0.2 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.0 GO:0071942 XPC complex(GO:0071942)
0.0 0.2 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.0 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0001527 microfibril(GO:0001527)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.1 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.1 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.1 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.0 0.2 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.1 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.2 GO:0046970 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0042805 actinin binding(GO:0042805)
0.0 0.1 GO:0051378 serotonin binding(GO:0051378)
0.0 0.1 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0 0.1 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.1 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0 0.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.0 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.0 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0 0.0 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.0 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.0 GO:0043175 RNA polymerase core enzyme binding(GO:0043175)
0.0 0.1 GO:0098988 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.4 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.0 REACTOME PI 3K CASCADE Genes involved in PI-3K cascade
0.0 0.0 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.0 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.0 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.1 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.1 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.1 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.0 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.1 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1