Project

ENCODE: H3K4me3 ChIP-Seq of primary human cells

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for HES7_HES5

Z-value: 0.69

Motif logo

Transcription factors associated with HES7_HES5

Gene Symbol	Gene ID	Gene Info
HES7 Ensembl NCBI GeneCards UniProt	ENSG00000179111.4	HES7
HES5 Ensembl NCBI GeneCards UniProt	ENSG00000197921.5	HES5

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
HES5	chr1_2467250_2467401	5641	0.102622	0.41	2.7e-01	Click!
HES5	chr1_2461361_2461622	193	0.883039	0.33	3.9e-01	Click!
HES5	chr1_2462303_2462454	694	0.498546	0.31	4.1e-01	Click!
HES5	chr1_2460280_2460431	1329	0.250275	0.29	4.5e-01	Click!
HES5	chr1_2460577_2460728	1032	0.331461	0.12	7.5e-01	Click!
HES7	chr17_8029184_8029766	2065	0.148924	0.22	5.7e-01	Click!
HES7	chr17_8025015_8025782	2004	0.149938	0.21	5.9e-01	Click!
HES7	chr17_8025785_8026039	1490	0.202056	-0.21	6.0e-01	Click!
HES7	chr17_8028639_8028790	1304	0.235636	0.19	6.3e-01	Click!
HES7	chr17_8026048_8026346	1205	0.255059	-0.16	6.8e-01	Click!

Activity of the HES7_HES5 motif across conditions

Conditions sorted by the z-value of the HES7_HES5 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_9714142_9714379	0.84	C1orf200	chromosome 1 open reading frame 200	384	0.82
chr2_158295494_158296053	0.71	CYTIP	cytohesin 1 interacting protein	153	0.96
chr11_2291181_2291518	0.70	ASCL2	achaete-scute family bHLH transcription factor 2	833	0.53
chr14_105527312_105527781	0.63	GPR132	G protein-coupled receptor 132	3727	0.23
chr1_154378708_154379562	0.58	RP11-350G8.5		95	0.93
chr7_644134_644285	0.55	AC147651.4		1387	0.35
chr3_196367453_196367902	0.51	PIGX	phosphatidylinositol glycan anchor biosynthesis, class X	1031	0.33
chr21_34395985_34396161	0.50	OLIG2	oligodendrocyte lineage transcription factor 2	2080	0.33
chr9_132647660_132648047	0.45	FNBP1	formin binding protein 1	33736	0.12
chr19_18507519_18507670	0.44	LRRC25	leucine rich repeat containing 25	827	0.4
chr20_55965895_55966111	0.44	RBM38	RNA binding motif protein 38	460	0.74
chr7_157368911_157369331	0.43	ENSG00000207960	.	2007	0.35
chr2_68589306_68589626	0.41	PLEK	pleckstrin	2839	0.22
chr1_160678982_160679166	0.41	CD48	CD48 molecule	2519	0.24
chr11_48029600_48029751	0.39	AC103828.1		7732	0.21
chrX_56839719_56839908	0.35	ENSG00000204272	.	84121	0.1
chr2_202129112_202129390	0.33	CASP8	caspase 8, apoptosis-related cysteine peptidase	2572	0.28
chr21_45773621_45773812	0.33	TRPM2	transient receptor potential cation channel, subfamily M, member 2	145	0.91
chr19_890673_890824	0.33	MED16	mediator complex subunit 16	383	0.68
chr1_226250996_226251291	0.32	H3F3A	H3 histone, family 3A	535	0.7
chr7_75622802_75623087	0.32	POR	P450 (cytochrome) oxidoreductase	11715	0.16
chr13_30120185_30120336	0.32	SLC7A1	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	40669	0.18
chr4_18023348_18023557	0.32	LCORL	ligand dependent nuclear receptor corepressor-like	31	0.99
chr19_19738537_19738987	0.31	LPAR2	lysophosphatidic acid receptor 2	153	0.92
chr2_27487055_27487432	0.30	SLC30A3	solute carrier family 30 (zinc transporter), member 3	239	0.85
chr15_75471070_75471460	0.30	C15orf39	chromosome 15 open reading frame 39	16719	0.13
chr22_20785488_20785753	0.30	SCARF2	scavenger receptor class F, member 2	6492	0.12
chr1_154976315_154976466	0.29	ZBTB7B	zinc finger and BTB domain containing 7B	1095	0.25
chr19_13928529_13928680	0.28	ZSWIM4	zinc finger, SWIM-type containing 4	91	0.92
chr10_71905035_71905382	0.28	TYSND1	trypsin domain containing 1	1134	0.47
chr11_65153709_65153977	0.28	FRMD8	FERM domain containing 8	227	0.87
chr2_61112543_61112833	0.28	REL	v-rel avian reticuloendotheliosis viral oncogene homolog	3897	0.23
chr19_35838935_35839086	0.28	ENSG00000263397	.	2594	0.13
chr16_87888685_87888836	0.27	SLC7A5	solute carrier family 7 (amino acid transporter light chain, L system), member 5	8485	0.17
chr12_102165709_102165860	0.26	ENSG00000222255	.	6497	0.11
chr16_89042817_89042968	0.26	CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	509	0.75
chr8_28259515_28259714	0.25	ZNF395	zinc finger protein 395	604	0.66
chr16_48419475_48419990	0.25	SIAH1	siah E3 ubiquitin protein ligase 1	371	0.85
chr12_663051_663343	0.25	B4GALNT3	beta-1,4-N-acetyl-galactosaminyl transferase 3	10898	0.16
chr20_49011186_49011337	0.24	ENSG00000244376	.	34759	0.19
chr9_92099141_92099337	0.24	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	4434	0.26
chr6_133134294_133134903	0.24	RPS12	ribosomal protein S12	982	0.36
chr7_130597934_130598170	0.24	ENSG00000226380	.	35754	0.19
chr2_192306449_192306600	0.23	MYO1B	myosin IB	30733	0.22
chr17_40440858_40441114	0.23	STAT5A	signal transducer and activator of transcription 5A	425	0.75
chr14_104604081_104604495	0.23	CTD-2223O18.1		53	0.93
chr12_4381475_4382675	0.23	CCND2	cyclin D2	863	0.52
chr20_826059_826564	0.23	FAM110A	family with sequence similarity 110, member A	544	0.82
chr15_81316371_81316635	0.22	C15orf26	chromosome 15 open reading frame 26	17129	0.15
chr10_131908264_131908714	0.22	GLRX3	glutaredoxin 3	26174	0.26
chr9_136727740_136727891	0.21	SARDH	sarcosine dehydrogenase	122738	0.05
chr22_23527376_23527533	0.21	BCR	breakpoint cluster region	4902	0.16
chr2_102974021_102974195	0.20	IL18R1	interleukin 18 receptor 1	1719	0.35
chr19_17828394_17828681	0.20	MAP1S	microtubule-associated protein 1S	1514	0.3
chr16_88987498_88987922	0.20	RP11-830F9.7		16454	0.11
chr6_29911146_29911299	0.20	HLA-A	major histocompatibility complex, class I, A	896	0.59
chr1_192777226_192777377	0.19	RGS2	regulator of G-protein signaling 2, 24kDa	870	0.71
chr13_34116896_34117047	0.19	STARD13	StAR-related lipid transfer (START) domain containing 13	192204	0.03
chr9_36142717_36143534	0.18	GLIPR2	GLI pathogenesis-related 2	6383	0.2
chr19_6425590_6425914	0.18	KHSRP	KH-type splicing regulatory protein	947	0.34
chr12_108056413_108056564	0.18	ENSG00000222160	.	11922	0.16
chr9_136602785_136602936	0.18	SARDH	sarcosine dehydrogenase	617	0.78
chr10_28622520_28622887	0.18	MPP7	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	712	0.72
chr10_103539328_103539744	0.18	NPM3	nucleophosmin/nucleoplasmin 3	3634	0.18
chr7_26191850_26192061	0.17	NFE2L3	nuclear factor, erythroid 2-like 3	95	0.97
chr3_176919226_176919959	0.17	TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	4331	0.31
chr1_226645087_226645238	0.17	ENSG00000223282	.	11524	0.22
chr6_117869124_117869373	0.17	GOPC	golgi-associated PDZ and coiled-coil motif containing	54279	0.12
chr17_40439619_40439799	0.17	STAT5A	signal transducer and activator of transcription 5A	144	0.93
chrX_70401472_70401874	0.17	RP5-1091N2.9		16352	0.12
chr19_58898175_58898426	0.17	ENSG00000266640	.	75	0.77
chr4_140476590_140476990	0.17	SETD7	SET domain containing (lysine methyltransferase) 7	572	0.65
chr15_41804782_41804942	0.17	LTK	leukocyte receptor tyrosine kinase	1132	0.4
chr16_1980035_1980237	0.16	HS3ST6	heparan sulfate (glucosamine) 3-O-sulfotransferase 6	11695	0.06
chr2_43452270_43452631	0.16	ZFP36L2	ZFP36 ring finger protein-like 2	1298	0.5
chr1_160316893_160317044	0.16	NCSTN	nicastrin	2484	0.17
chr2_190442035_190442186	0.16	SLC40A1	solute carrier family 40 (iron-regulated transporter), member 1	3503	0.3
chr1_27668600_27669070	0.16	SYTL1	synaptotagmin-like 1	322	0.82
chr10_6018795_6019199	0.16	IL15RA	interleukin 15 receptor, alpha	180	0.93
chr6_99282314_99282478	0.16	POU3F2	POU class 3 homeobox 2	184	0.97
chr3_133292516_133292718	0.15	CDV3	CDV3 homolog (mouse)	43	0.98
chr14_51296169_51297325	0.15	NIN	ninein (GSK3B interacting protein)	450	0.76
chr16_81129212_81129933	0.15	GCSH	glycine cleavage system protein H (aminomethyl carrier)	273	0.86
chr2_25149877_25150037	0.15	ADCY3	adenylate cyclase 3	7249	0.18
chr6_111197567_111198255	0.15	AMD1	adenosylmethionine decarboxylase 1	1133	0.45
chr7_74988426_74988792	0.15	STAG3L1	stromal antigen 3-like 1 (pseudogene)	154	0.91
chr4_154217109_154217260	0.15	ENSG00000201786	.	29022	0.14
chr1_25944160_25944528	0.15	MAN1C1	mannosidase, alpha, class 1C, member 1	3	0.98
chr18_43431286_43431437	0.15	SIGLEC15	sialic acid binding Ig-like lectin 15	13555	0.2
chr16_85089458_85089881	0.15	KIAA0513	KIAA0513	7149	0.23
chr4_113153042_113153239	0.15	AP1AR	adaptor-related protein complex 1 associated regulatory protein	151	0.76
chr7_66767653_66767865	0.15	PMS2P4	postmeiotic segregation increased 2 pseudogene 4	135	0.95
chr11_64108635_64108896	0.14	CCDC88B	coiled-coil domain containing 88B	1070	0.28
chr3_156391824_156392138	0.14	TIPARP	TCDD-inducible poly(ADP-ribose) polymerase	150	0.55
chr22_37881004_37881696	0.14	MFNG	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	683	0.62
chr21_43933401_43933705	0.14	SLC37A1	solute carrier family 37 (glucose-6-phosphate transporter), member 1	471	0.74
chr11_93394564_93394780	0.14	KIAA1731	KIAA1731	133	0.94
chr1_156426947_156427327	0.14	MEF2D	myocyte enhancer factor 2D	26085	0.1
chr11_65185943_65186437	0.14	ENSG00000245532	.	25739	0.09
chr1_144521538_144522007	0.14	RP11-640M9.1		198	0.94
chr7_5597597_5597858	0.13	CTB-161C1.1		1365	0.33
chr9_92219727_92219878	0.13	GADD45G	growth arrest and DNA-damage-inducible, gamma	126	0.98
chr15_85523451_85523602	0.13	PDE8A	phosphodiesterase 8A	145	0.96
chr16_85605071_85605483	0.13	GSE1	Gse1 coiled-coil protein	39738	0.16
chr15_101548752_101549003	0.13	RP11-505E24.3		40784	0.16
chr17_42988666_42988862	0.13	GFAP	glial fibrillary acidic protein	745	0.46
chr2_20849968_20850393	0.13	HS1BP3	HCLS1 binding protein 3	658	0.74
chr14_23025391_23025542	0.13	AE000662.92	Uncharacterized protein	68	0.87
chr3_49026937_49027533	0.13	P4HTM	prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)	84	0.63
chrX_118827540_118827798	0.13	SEPT6	septin 6	336	0.88
chr19_48103713_48103864	0.13	GLTSCR1	glioma tumor suppressor candidate region gene 1	7665	0.14
chr2_198071025_198071176	0.13	ANKRD44	ankyrin repeat domain 44	8338	0.21
chr8_145192644_145192918	0.13	FAM203A	family with sequence similarity 203, member A	109	0.93
chr22_45634545_45634696	0.13	KIAA0930	KIAA0930	2030	0.3
chr10_75531995_75532402	0.13	FUT11	fucosyltransferase 11 (alpha (1,3) fucosyltransferase)	149	0.52
chr1_143744977_143745422	0.13	PPIAL4G	peptidylprolyl isomerase A (cyclophilin A)-like 4G	22682	0.16
chr6_13488651_13488802	0.13	GFOD1	glucose-fructose oxidoreductase domain containing 1	832	0.5
chr1_202611622_202611773	0.13	SYT2	synaptotagmin II	884	0.64
chr11_72853542_72853693	0.12	FCHSD2	FCH and double SH3 domains 2	311	0.91
chr13_21050204_21050392	0.12	ENSG00000263978	.	42313	0.15
chr9_94186787_94187440	0.12	NFIL3	nuclear factor, interleukin 3 regulated	969	0.69
chr19_917582_917891	0.12	KISS1R	KISS1 receptor	233	0.83
chr10_129846734_129847253	0.12	PTPRE	protein tyrosine phosphatase, receptor type, E	1159	0.62
chr6_143771128_143771800	0.12	ADAT2	adenosine deaminase, tRNA-specific 2	346	0.45
chr8_28352405_28352827	0.12	FZD3	frizzled family receptor 3	843	0.51
chr1_144341547_144341785	0.12	AL592284.1	Protein LOC642441	1928	0.34
chr3_25825194_25825429	0.12	NGLY1	N-glycanase 1	269	0.8
chr2_74648754_74648905	0.12	WDR54	WD repeat domain 54	27	0.58
chr11_69489461_69490079	0.12	ORAOV1	oral cancer overexpressed 1	319	0.9
chr16_68319324_68319536	0.12	ENSG00000252026	.	1209	0.25
chr1_147932755_147932982	0.12	PPIAL4A	peptidylprolyl isomerase A (cyclophilin A)-like 4A	22551	0.16
chr3_135969527_135970046	0.12	PCCB	propionyl CoA carboxylase, beta polypeptide	299	0.94
chr7_72476067_72476443	0.11	STAG3L3	stromal antigen 3-like 3	185	0.89
chrX_53710808_53711038	0.11	HUWE1	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	191	0.97
chr8_145114785_145114936	0.11	OPLAH	5-oxoprolinase (ATP-hydrolysing)	724	0.42
chr5_49961781_49962268	0.11	PARP8	poly (ADP-ribose) polymerase family, member 8	184	0.97
chr3_9885443_9885670	0.11	RPUSD3	RNA pseudouridylate synthase domain containing 3	70	0.94
chr12_104964115_104964290	0.11	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	18424	0.22
chr6_144536832_144537278	0.11	STX11	syntaxin 11	65392	0.12
chr11_47416116_47416267	0.11	RP11-750H9.5		1000	0.33
chr14_99726709_99727240	0.11	AL109767.1		2311	0.33
chr1_145455050_145455272	0.11	POLR3GL	polymerase (RNA) III (DNA directed) polypeptide G (32kD)-like	15226	0.1
chr7_101460813_101461304	0.11	CUX1	cut-like homeobox 1	138	0.97
chr6_139456178_139456587	0.11	HECA	headcase homolog (Drosophila)	133	0.97
chr8_74206830_74207171	0.11	RDH10	retinol dehydrogenase 10 (all-trans)	153	0.72
chr10_89823812_89823963	0.11	ENSG00000200891	.	69435	0.12
chr11_1874347_1875032	0.11	LSP1	lymphocyte-specific protein 1	489	0.65
chr12_57080547_57081320	0.11	PTGES3	prostaglandin E synthase 3 (cytosolic)	1013	0.41
chr11_107992319_107993285	0.11	ACAT1	acetyl-CoA acetyltransferase 1	279	0.6
chr22_40742518_40742799	0.11	ADSL	adenylosuccinate lyase	122	0.96
chr17_80188177_80188492	0.11	SLC16A3	solute carrier family 16 (monocarboxylate transporter), member 3	1365	0.28
chr3_38496543_38496888	0.11	ACVR2B-AS1	ACVR2B antisense RNA 1	404	0.78
chr20_5588883_5589774	0.10	GPCPD1	glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)	2344	0.4
chr5_138724836_138724987	0.10	MZB1	marginal zone B and B1 cell-specific protein	675	0.5
chr19_14544413_14545000	0.10	PKN1	protein kinase N1	401	0.76
chr9_71148060_71148211	0.10	TMEM252	transmembrane protein 252	7648	0.27
chr19_8289482_8289633	0.10	CERS4	ceramide synthase 4	354	0.85
chr22_36425098_36425275	0.10	RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	713	0.78
chr17_25958886_25959081	0.10	LGALS9	lectin, galactoside-binding, soluble, 9	750	0.6
chr11_2324171_2324374	0.10	TSPAN32	tetraspanin 32	174	0.88
chr11_121526465_121526781	0.10	SORL1	sortilin-related receptor, L(DLR class) A repeats containing	65495	0.14
chr18_74280302_74280453	0.10	LINC00908	long intergenic non-protein coding RNA 908	39503	0.16
chr1_46154130_46154324	0.10	TMEM69	transmembrane protein 69	1341	0.32
chr1_148176495_148177244	0.10	PPIAL4D	peptidylprolyl isomerase A (cyclophilin A)-like 4D	25667	0.21
chr10_99093753_99093904	0.10	RP11-452K12.4		493	0.49
chr11_66405551_66405805	0.10	RBM4	RNA binding motif protein 4	410	0.71
chr14_52784712_52784898	0.10	PTGER2	prostaglandin E receptor 2 (subtype EP2), 53kDa	3692	0.31
chr4_139936230_139936672	0.10	CCRN4L	CCR4 carbon catabolite repression 4-like (S. cerevisiae)	492	0.71
chr7_150415780_150415950	0.10	GIMAP1	GTPase, IMAP family member 1	2220	0.26
chr11_76869474_76869625	0.10	MYO7A	myosin VIIA	21322	0.2
chr5_159894836_159895683	0.10	ENSG00000265237	.	6150	0.17
chr6_41908853_41909458	0.10	CCND3	cyclin D3	36	0.97
chr16_67189130_67189364	0.10	TRADD	TNFRSF1A-associated via death domain	905	0.31
chr8_145437857_145438162	0.10	FAM203B	family with sequence similarity 203, member B	129	0.94
chr1_236445510_236445882	0.10	ERO1LB	ERO1-like beta (S. cerevisiae)	377	0.86
chr2_152495160_152495321	0.09	NEB	nebulin	55107	0.16
chr3_10183779_10183952	0.09	VHL	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	393	0.67
chr13_41239028_41239270	0.09	FOXO1	forkhead box O1	1585	0.46
chr7_5595191_5595362	0.09	CTB-161C1.1		1086	0.41
chr17_40441446_40441597	0.09	STAT5A	signal transducer and activator of transcription 5A	960	0.43
chr8_38240572_38240933	0.09	WHSC1L1	Wolf-Hirschhorn syndrome candidate 1-like 1	962	0.42
chr1_894870_895078	0.09	NOC2L	nucleolar complex associated 2 homolog (S. cerevisiae)	304	0.72
chr22_24038076_24038227	0.09	RGL4	ral guanine nucleotide dissociation stimulator-like 4	520	0.69
chr5_118734822_118734973	0.09	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	43167	0.13
chr3_37934486_37934637	0.09	CTDSPL	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like	30896	0.15
chr1_173836617_173837079	0.09	ENSG00000234741	.	40	0.83
chr4_166128900_166129705	0.09	KLHL2	kelch-like family member 2	327	0.55
chr7_99933726_99933950	0.09	PILRB	paired immunoglobin-like type 2 receptor beta	101	0.92
chr18_33078024_33078260	0.09	INO80C	INO80 complex subunit C	187	0.57
chr8_65711600_65711819	0.09	CYP7B1	cytochrome P450, family 7, subfamily B, polypeptide 1	391	0.91
chr1_27019608_27020111	0.09	RP5-968P14.2		763	0.56
chr12_25204572_25204723	0.09	LRMP	lymphoid-restricted membrane protein	558	0.78
chr2_149401643_149402183	0.09	EPC2	enhancer of polycomb homolog 2 (Drosophila)	96	0.98
chr3_195634754_195635357	0.09	TNK2-AS1	TNK2 antisense RNA 1	108	0.91
chr12_122249441_122249966	0.09	SETD1B	SET domain containing 1B	7065	0.16
chr12_109024686_109024975	0.09	SELPLG	selectin P ligand	1024	0.4
chr14_99741095_99741246	0.09	BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)	3309	0.27
chr11_58345573_58345832	0.09	LPXN	leupaxin	9	0.95
chr20_23066190_23066341	0.09	CD93	CD93 molecule	712	0.66
chr2_38871082_38871242	0.09	GALM	galactose mutarotase (aldose 1-epimerase)	21890	0.15

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HES7_HES5

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0046449	allantoin metabolic process(GO:0000255) creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.1	0.4	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.1	0.3	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.1	0.3	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.1	0.3	GO:0006546	glycine catabolic process(GO:0006546)
0.1	0.2	GO:0021529	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.1	0.3	GO:0061088	regulation of sequestering of zinc ion(GO:0061088)
0.0	0.1	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.1	GO:0060449	bud elongation involved in lung branching(GO:0060449)
0.0	0.1	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.1	GO:0033622	integrin activation(GO:0033622)
0.0	0.1	GO:0019255	glucose 1-phosphate metabolic process(GO:0019255)
0.0	0.1	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0060242	contact inhibition(GO:0060242)
0.0	0.1	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.1	GO:0018027	peptidyl-lysine dimethylation(GO:0018027)
0.0	0.1	GO:0060431	primary lung bud formation(GO:0060431)
0.0	0.1	GO:0021754	facial nucleus development(GO:0021754)
0.0	0.1	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.1	GO:0043441	acetoacetic acid biosynthetic process(GO:0043441)
0.0	0.1	GO:0002085	inhibition of neuroepithelial cell differentiation(GO:0002085)
0.0	0.1	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.0	GO:0051790	short-chain fatty acid biosynthetic process(GO:0051790)
0.0	0.1	GO:0051642	centrosome localization(GO:0051642)
0.0	0.0	GO:0032928	regulation of superoxide anion generation(GO:0032928)
0.0	0.2	GO:1904031	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0	0.2	GO:0030851	granulocyte differentiation(GO:0030851)
0.0	0.0	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.0	0.1	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.0	GO:0071436	sodium ion export(GO:0071436)
0.0	0.1	GO:0006307	DNA dealkylation involved in DNA repair(GO:0006307)
0.0	0.0	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.0	0.0	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0	0.1	GO:0071354	cellular response to interleukin-6(GO:0071354)
0.0	0.1	GO:0010614	negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0	0.0	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.1	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0	0.0	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.2	GO:0016254	preassembly of GPI anchor in ER membrane(GO:0016254)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.1	GO:0042583	chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.1	GO:0031932	TORC2 complex(GO:0031932)
0.1	GO:0030891	VCB complex(GO:0030891)
0.1	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.1	GO:0031105	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	GO:0044462	external encapsulating structure part(GO:0044462)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.1	0.2	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.1	0.3	GO:0004047	aminomethyltransferase activity(GO:0004047)
0.0	0.3	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.1	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.0	0.2	GO:0016885	ligase activity, forming carbon-carbon bonds(GO:0016885)
0.0	0.1	GO:0003985	acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.1	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.2	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.1	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.3	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.0	0.0	GO:0015924	mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0	0.1	GO:0005534	galactose binding(GO:0005534)
0.0	0.1	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.2	GO:0070888	E-box binding(GO:0070888)
0.0	0.1	GO:0009008	DNA-methyltransferase activity(GO:0009008)
0.0	0.1	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.0	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.1	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.0	0.2	GO:0032393	MHC class I receptor activity(GO:0032393)
0.0	0.1	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.0	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.0	0.2	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0	0.0	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	PID IL5 PATHWAY	IL5-mediated signaling events
0.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.4	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.2	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.3	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.2	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis