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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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Results for HIF1A

Z-value: 0.62

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Transcription factors associated with HIF1A

Gene Symbol Gene ID Gene Info
HIF1A
ENSG00000100644.12 hypoxia inducible factor 1 subunit alpha

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr14_62168732_62168883HIF1A44670.2765810.581.1e-01Click!
chr14_62171830_62171981HIF1A75650.2496670.571.1e-01Click!
chr14_62185926_62186077HIF1A216610.2108630.521.5e-01Click!
chr14_62144501_62144652HIF1A176820.211114-0.491.8e-01Click!
chr14_62144211_62144362HIF1A179720.210257-0.462.2e-01Click!

Activity of the HIF1A motif across conditions

Conditions sorted by the z-value of the HIF1A motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr7_55087325_55087551 0.38 EGFR
 epidermal growth factor receptor
 627
 0.83
chr14_30396439_30396658 0.32 PRKD1
 protein kinase D1
 300
 0.93
chr4_17783154_17783359 0.27 FAM184B
 family with sequence similarity 184, member B
 121
 0.97
chr11_57406082_57406969 0.26 AP000662.4
676
 0.5
chr5_131991447_131991948 0.25 AC004041.2
113
 0.94
chr3_171918528_171919229 0.24 ENSG00000243398
 .
 36238
 0.18
chr19_46916092_46916684 0.24 CCDC8
 coiled-coil domain containing 8
 453
 0.75
chr12_58120609_58120962 0.23 AGAP2-AS1
 AGAP2 antisense RNA 1
 731
 0.39
chr4_183064801_183065567 0.23 AC108142.1
143
 0.83
chr15_95869891_95870263 0.23 ENSG00000222076
 .
 418956
 0.01
chr14_55119300_55119828 0.21 SAMD4A
 sterile alpha motif domain containing 4A
 84927
 0.09
chr5_169172915_169173066 0.21 DOCK2
 dedicator of cytokinesis 2
 13731
 0.24
chr5_83017716_83018280 0.21 HAPLN1
 hyaluronan and proteoglycan link protein 1
 566
 0.78
chr11_35640577_35641198 0.20 FJX1
 four jointed box 1 (Drosophila)
 1152
 0.57
chr15_83875054_83875562 0.19 HDGFRP3
 Hepatoma-derived growth factor-related protein 3
 1462
 0.4
chr18_24764849_24765000 0.19 CHST9
 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
 338
 0.94
chr5_9546456_9546803 0.19 SEMA5A
 sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
 442
 0.8
chrX_107179250_107179655 0.18 RP6-191P20.4
242
 0.93
chr17_59476045_59476898 0.17 RP11-332H18.4
260
 0.74
chr5_172754207_172754714 0.17 STC2
 stanniocalcin 2
 596
 0.75
chr9_101983648_101983918 0.17 ALG2
 ALG2, alpha-1,3/1,6-mannosyltransferase
 454
 0.53
chr3_141088214_141088426 0.17 RP11-438D8.2
2341
 0.33
chr15_23931247_23932124 0.17 NDN
 necdin, melanoma antigen (MAGE) family member
 765
 0.7
chr10_122216113_122216362 0.17 PPAPDC1A
 phosphatidic acid phosphatase type 2 domain containing 1A
 229
 0.95
chr17_7342924_7343492 0.16 FGF11
 fibroblast growth factor 11
 9
 0.91
chr4_93226727_93227337 0.16 GRID2
 glutamate receptor, ionotropic, delta 2
 1224
 0.46
chrX_54385157_54385424 0.16 WNK3
 WNK lysine deficient protein kinase 3
 215
 0.95
chr19_13135793_13135990 0.16 NFIX
 nuclear factor I/X (CCAAT-binding transcription factor)
 80
 0.94
chrX_105969921_105970262 0.15 RNF128
 ring finger protein 128, E3 ubiquitin protein ligase
 197
 0.96
chr14_64804508_64805275 0.15 ESR2
 estrogen receptor 2 (ER beta)
 61
 0.87
chr20_4129930_4130735 0.15 SMOX
 spermine oxidase
 750
 0.71
chr3_159482295_159482916 0.15 IQCJ-SCHIP1
 IQCJ-SCHIP1 readthrough
 287
 0.9
chr16_56660383_56660534 0.15 MT1E
 metallothionein 1E
 748
 0.38
chr6_138571879_138572276 0.15 PBOV1
 prostate and breast cancer overexpressed 1
 32450
 0.2
chr10_13931045_13931263 0.15 FRMD4A
 FERM domain containing 4A
 30242
 0.2
chr14_69013839_69014176 0.15 CTD-2325P2.4
81155
 0.1
chrX_48930077_48930476 0.15 PRAF2
 PRA1 domain family, member 2
 1372
 0.22
chr13_37494481_37494632 0.15 SMAD9
 SMAD family member 9
 147
 0.96
chr10_16562894_16563258 0.15 C1QL3
 complement component 1, q subcomponent-like 3
 928
 0.63
chr4_23890359_23890765 0.14 PPARGC1A
 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
 1096
 0.66
chr4_115519485_115519837 0.14 UGT8
 UDP glycosyltransferase 8
 50
 0.99
chr7_15725092_15725754 0.14 MEOX2
 mesenchyme homeobox 2
 1014
 0.63
chr3_133646028_133646432 0.14 C3orf36
 chromosome 3 open reading frame 36
 2426
 0.34
chr20_11138132_11138283 0.14 C20orf187
 chromosome 20 open reading frame 187
 129396
 0.06
chr9_133884490_133884806 0.14 LAMC3
 laminin, gamma 3
 179
 0.95
chr3_170137410_170137695 0.14 CLDN11
 claudin 11
 697
 0.77
chr11_2187699_2187850 0.14 TH
 tyrosine hydroxylase
 1562
 0.23
chr7_43152327_43152563 0.14 HECW1
 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
 201
 0.93
chr10_49731531_49732112 0.14 ARHGAP22
 Rho GTPase activating protein 22
 460
 0.85
chr11_119455314_119455975 0.14 RP11-196E1.3
23491
 0.19
chr1_158968705_158968932 0.14 IFI16
 interferon, gamma-inducible protein 16
 940
 0.6
chr19_49575534_49575685 0.14 KCNA7
 potassium voltage-gated channel, shaker-related subfamily, member 7
 589
 0.44
chr6_7909475_7910402 0.13 TXNDC5
 thioredoxin domain containing 5 (endoplasmic reticulum)
 372
 0.92
chr6_169653425_169653684 0.13 THBS2
 thrombospondin 2
 585
 0.83
chr1_16399640_16399936 0.13 FAM131C
 family with sequence similarity 131, member C
 333
 0.84
chr15_91500342_91500803 0.13 RCCD1
 RCC1 domain containing 1
 1546
 0.18
chr18_8706613_8707165 0.13 SOGA2
 SOGA family member 2
 520
 0.55
chr7_94536809_94537187 0.13 PPP1R9A
 protein phosphatase 1, regulatory subunit 9A
 11
 0.99
chr19_55591836_55592067 0.13 EPS8L1
 EPS8-like 1
 191
 0.89
chr5_81701799_81702115 0.13 ATP6AP1L
 ATPase, H+ transporting, lysosomal accessory protein 1-like
 100791
 0.08
chr19_53561526_53561765 0.13 ERVV-2
 endogenous retrovirus group V, member 2
 13654
 0.13
chr8_37823203_37823407 0.13 ADRB3
 adrenoceptor beta 3
 1178
 0.39
chr3_62359874_62360076 0.13 FEZF2
 FEZ family zinc finger 2
 24
 0.98
chr14_75389218_75389970 0.13 RPS6KL1
 ribosomal protein S6 kinase-like 1
 360
 0.84
chr9_22005843_22006115 0.12 CDKN2B
 cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
 2973
 0.2
chr16_22826079_22826361 0.12 HS3ST2
 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
 722
 0.79
chr7_28076392_28076791 0.12 JAZF1
 JAZF zinc finger 1
 16173
 0.26
chr22_43115644_43116713 0.12 A4GALT
 alpha 1,4-galactosyltransferase
 24539
 0.15
chr20_19738276_19738696 0.12 AL121761.2
 Uncharacterized protein
 193
 0.95
chr16_21312757_21313165 0.12 CRYM
 crystallin, mu
 1411
 0.46
chr22_44433690_44434013 0.12 PARVB
 parvin, beta
 6606
 0.26
chr7_47576453_47576928 0.12 TNS3
 tensin 3
 2185
 0.45
chr1_1490221_1490372 0.12 TMEM240
 transmembrane protein 240
 14463
 0.09
chr9_8733649_8733843 0.12 PTPRD
 protein tyrosine phosphatase, receptor type, D
 148
 0.97
chr15_73976688_73977423 0.12 CD276
 CD276 molecule
 17
 0.98
chr2_74968036_74968578 0.11 SEMA4F
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
 86869
 0.07
chr11_60609533_60610326 0.11 CCDC86
 coiled-coil domain containing 86
 385
 0.51
chr8_42356526_42357223 0.11 SLC20A2
 solute carrier family 20 (phosphate transporter), member 2
 1887
 0.34
chr5_38846105_38846894 0.11 OSMR
 oncostatin M receptor
 398
 0.91
chr1_16275488_16275712 0.11 ZBTB17
 zinc finger and BTB domain containing 17
 4677
 0.16
chr17_1665908_1666244 0.11 SERPINF1
 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
 47
 0.96
chr7_116660327_116660575 0.11 ST7
 suppression of tumorigenicity 7
 120
 0.96
chr20_53092350_53092560 0.11 DOK5
 docking protein 5
 198
 0.97
chr11_133907029_133907299 0.11 JAM3
 junctional adhesion molecule 3
 31656
 0.18
chr7_56183478_56183932 0.11 NUPR1L
 nuclear protein, transcriptional regulator, 1-like
 388
 0.78
chr11_19367315_19367499 0.11 NAV2
 neuron navigator 2
 4864
 0.23
chr6_1381911_1382148 0.11 RP4-668J24.2
3272
 0.28
chr15_83316430_83317127 0.11 CPEB1
 cytoplasmic polyadenylation element binding protein 1
 50
 0.76
chr8_15095014_15095265 0.11 SGCZ
 sarcoglycan, zeta
 709
 0.82
chr2_239072349_239072829 0.11 FAM132B
 family with sequence similarity 132, member B
 385
 0.8
chr11_33397614_33397834 0.11 ENSG00000223134
 .
 21713
 0.24
chr20_13976647_13977145 0.11 SEL1L2
 sel-1 suppressor of lin-12-like 2 (C. elegans)
 193
 0.78
chr19_1241899_1242560 0.11 ATP5D
 ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
 410
 0.68
chr4_142053459_142053770 0.10 RNF150
 ring finger protein 150
 382
 0.92
chr6_54564223_54564374 0.10 ENSG00000251946
 .
 86887
 0.1
chr5_122425011_122425806 0.10 AC106786.1
418
 0.57
chr1_17019431_17019582 0.10 ENSG00000264742
 .
 11756
 0.12
chr18_43913317_43913996 0.10 RNF165
 ring finger protein 165
 275
 0.95
chr20_33300382_33300533 0.10 TP53INP2
 tumor protein p53 inducible nuclear protein 2
 7918
 0.22
chr10_5708404_5708555 0.10 ASB13
 ankyrin repeat and SOCS box containing 13
 62
 0.97
chr7_41736310_41736535 0.10 INHBA-AS1
 INHBA antisense RNA 1
 2876
 0.26
chr1_214156478_214156705 0.10 PROX1
 prospero homeobox 1
 67
 0.98
chr19_290704_290961 0.10 PPAP2C
 phosphatidic acid phosphatase type 2C
 338
 0.87
chr4_8271771_8271998 0.10 HTRA3
 HtrA serine peptidase 3
 380
 0.89
chr20_19956104_19956326 0.10 NAA20
 N(alpha)-acetyltransferase 20, NatB catalytic subunit
 41545
 0.15
chr19_44951986_44952721 0.10 ZNF229
 zinc finger protein 229
 296
 0.89
chr13_20751391_20751542 0.10 LINC00556
 long intergenic non-protein coding RNA 556
 4204
 0.21
chr13_114048059_114048366 0.10 GRTP1
 growth hormone regulated TBC protein 1
 29771
 0.13
chr4_17782801_17783007 0.10 FAM184B
 family with sequence similarity 184, member B
 231
 0.94
chr15_75931462_75932480 0.10 IMP3
 IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
 581
 0.57
chr9_35907347_35908019 0.10 HRCT1
 histidine rich carboxyl terminus 1
 1494
 0.3
chr7_100167546_100168141 0.10 SAP25
 Sin3A-associated protein, 25kDa
 3427
 0.11
chr10_123922760_123923208 0.10 TACC2
 transforming, acidic coiled-coil containing protein 2
 43
 0.99
chr18_24155058_24155571 0.10 ENSG00000252846
 .
 11448
 0.22
chr8_143695363_143695514 0.10 ARC
 activity-regulated cytoskeleton-associated protein
 1395
 0.35
chr13_44947783_44948184 0.10 SERP2
 stress-associated endoplasmic reticulum protein family member 2
 5
 0.99
chr1_31480017_31480289 0.10 PUM1
 pumilio RNA-binding family member 1
 12202
 0.19
chr4_124426780_124427488 0.10 SPRY1
 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
 106011
 0.08
chr9_101469729_101470145 0.10 GABBR2
 gamma-aminobutyric acid (GABA) B receptor, 2
 1542
 0.5
chr9_130330127_130331202 0.10 FAM129B
 family with sequence similarity 129, member B
 703
 0.67
chr2_242742783_242743231 0.10 AC114730.5
1685
 0.21
chr12_48513521_48513903 0.10 PFKM
 phosphofructokinase, muscle
 142
 0.94
chr9_111205795_111206154 0.10 ENSG00000222512
 .
 84765
 0.11
chr2_5831543_5831945 0.09 AC107057.2
124
 0.83
chr5_180669462_180669613 0.09 GNB2L1
 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
 291
 0.58
chr16_65154751_65155029 0.09 CDH11
 cadherin 11, type 2, OB-cadherin (osteoblast)
 943
 0.75
chrX_12156590_12157176 0.09 FRMPD4
 FERM and PDZ domain containing 4
 298
 0.9
chr18_22930019_22930221 0.09 ZNF521
 zinc finger protein 521
 1037
 0.66
chr2_242157667_242157840 0.09 ANO7
 anoctamin 7
 723
 0.57
chr9_136857518_136857728 0.09 VAV2
 vav 2 guanine nucleotide exchange factor
 103
 0.97
chr14_72231475_72231648 0.09 SIPA1L1
 signal-induced proliferation-associated 1 like 1
 146088
 0.04
chr19_3367591_3367973 0.09 NFIC
 nuclear factor I/C (CCAAT-binding transcription factor)
 1198
 0.48
chr6_28456937_28457274 0.09 GPX6
 glutathione peroxidase 6 (olfactory)
 26459
 0.14
chr15_44486029_44486998 0.09 FRMD5
 FERM domain containing 5
 131
 0.98
chr5_42424322_42424771 0.09 GHR
 growth hormone receptor
 520
 0.88
chr2_220283280_220283537 0.09 DES
 desmin
 309
 0.8
chr16_2835054_2835205 0.09 PRSS33
 protease, serine, 33
 1477
 0.19
chr5_11384809_11385052 0.09 CTNND2
 catenin (cadherin-associated protein), delta 2
 203993
 0.03
chr13_53174146_53174487 0.09 HNRNPA1L2
 heterogeneous nuclear ribonucleoprotein A1-like 2
 17289
 0.22
chr6_85483496_85483916 0.09 TBX18
 T-box 18
 9469
 0.3
chr12_3069053_3070004 0.09 TEAD4
 TEA domain family member 4
 445
 0.77
chr1_159924191_159924342 0.09 SLAMF9
 SLAM family member 9
 222
 0.88
chr10_123357016_123357770 0.09 FGFR2
 fibroblast growth factor receptor 2
 205
 0.97
chr1_55436937_55437088 0.09 TMEM61
 transmembrane protein 61
 9453
 0.16
chr11_11642193_11642674 0.09 GALNT18
 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18
 1119
 0.56
chr3_42922021_42922670 0.09 CYP8B1
 cytochrome P450, family 8, subfamily B, polypeptide 1
 4712
 0.15
chrX_48693575_48693797 0.09 PCSK1N
 proprotein convertase subtilisin/kexin type 1 inhibitor
 349
 0.78
chr18_31802690_31803001 0.09 RP11-379L18.1
84
 0.8
chr13_97646306_97646561 0.09 OXGR1
 oxoglutarate (alpha-ketoglutarate) receptor 1
 171
 0.96
chr7_128045105_128045914 0.09 IMPDH1
 IMP (inosine 5'-monophosphate) dehydrogenase 1
 487
 0.75
chr3_44040787_44041403 0.09 ENSG00000252980
 .
 71484
 0.12
chr19_36036432_36037158 0.09 AD000090.2
136
 0.59
chr10_81741543_81742003 0.09 SFTPD
 surfactant protein D
 597
 0.81
chr1_41961804_41962136 0.09 EDN2
 endothelin 2
 11628
 0.2
chr2_73518392_73518872 0.09 EGR4
 early growth response 4
 2197
 0.23
chr5_9547808_9548146 0.09 ENSG00000239112
 .
 971
 0.49
chr5_6449023_6449402 0.09 UBE2QL1
 ubiquitin-conjugating enzyme E2Q family-like 1
 476
 0.88
chr2_239756978_239757253 0.09 TWIST2
 twist family bHLH transcription factor 2
 442
 0.88
chr4_54966297_54966506 0.09 GSX2
 GS homeobox 2
 61
 0.97
chr1_230222759_230222910 0.08 GALNT2
 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
 19816
 0.23
chr1_8074798_8074959 0.08 ERRFI1
 ERBB receptor feedback inhibitor 1
 815
 0.65
chr13_93879365_93880233 0.08 GPC6
 glypican 6
 704
 0.82
chr13_27936373_27936791 0.08 ENSG00000252247
 .
 18699
 0.15
chr6_1611333_1611591 0.08 FOXC1
 forkhead box C1
 781
 0.77
chr2_240169087_240169238 0.08 HDAC4
 histone deacetylase 4
 56410
 0.1
chr3_44803922_44804142 0.08 KIF15
 kinesin family member 15
 678
 0.45
chr3_48722741_48723287 0.08 NCKIPSD
 NCK interacting protein with SH3 domain
 254
 0.86
chr16_48570079_48570232 0.08 RP11-44I10.3
23417
 0.17
chr1_92495646_92496322 0.08 EPHX4
 epoxide hydrolase 4
 445
 0.85
chr11_70244216_70245100 0.08 CTTN
 cortactin
 11
 0.53
chr6_28574388_28574671 0.08 SCAND3
 SCAN domain containing 3
 19417
 0.18
chr6_84139529_84139855 0.08 ME1
 malic enzyme 1, NADP(+)-dependent, cytosolic
 1072
 0.62
chr4_157862974_157863267 0.08 PDGFC
 platelet derived growth factor C
 28935
 0.19
chr5_150325496_150325780 0.08 ZNF300P1
 zinc finger protein 300 pseudogene 1
 213
 0.94
chr17_40932934_40933198 0.08 WNK4
 WNK lysine deficient protein kinase 4
 370
 0.71
chr19_17422589_17422876 0.08 ABHD8
 abhydrolase domain containing 8
 1687
 0.15
chrX_114467670_114468385 0.08 LRCH2
 leucine-rich repeats and calponin homology (CH) domain containing 2
 601
 0.77
chr9_116918690_116918954 0.08 COL27A1
 collagen, type XXVII, alpha 1
 982
 0.6
chr18_70534206_70534360 0.08 NETO1
 neuropilin (NRP) and tolloid (TLL)-like 1
 17
 0.98
chr21_35348616_35348984 0.08 LINC00649
 long intergenic non-protein coding RNA 649
 6980
 0.21
chr19_16179581_16179939 0.08 TPM4
 tropomyosin 4
 1250
 0.44
chr17_8533666_8534137 0.08 MYH10
 myosin, heavy chain 10, non-muscle
 134
 0.97
chr13_21295723_21296224 0.08 ENSG00000265710
 .
 18131
 0.18
chr19_55658159_55658310 0.08 TNNT1
 troponin T type 1 (skeletal, slow)
 76
 0.93
chr14_105965982_105966133 0.08 C14orf80
 chromosome 14 open reading frame 80
 8326
 0.11
chr8_23711375_23711668 0.08 STC1
 stanniocalcin 1
 303
 0.92
chr10_134581493_134581644 0.08 INPP5A
 inositol polyphosphate-5-phosphatase, 40kDa
 2240
 0.34
chr4_154149984_154150203 0.08 TRIM2
 tripartite motif containing 2
 24475
 0.17
chr6_160769471_160769667 0.08 SLC22A3
 solute carrier family 22 (organic cation transporter), member 3
 144
 0.98
chr5_15500636_15500842 0.08 FBXL7
 F-box and leucine-rich repeat protein 7
 434
 0.91
chr20_9048816_9049419 0.08 PLCB4
 phospholipase C, beta 4
 293
 0.9
chr21_35319646_35320126 0.08 LINC00649
 long intergenic non-protein coding RNA 649
 1144
 0.46
chr5_343986_344609 0.08 AHRR
 aryl-hydrocarbon receptor repressor
 654
 0.71
chr11_65666966_65667198 0.08 FOSL1
 FOS-like antigen 1
 808
 0.38
chr22_39638932_39639142 0.08 PDGFB
 platelet-derived growth factor beta polypeptide
 16
 0.97
chr15_63664855_63665177 0.08 CA12
 carbonic anhydrase XII
 9018
 0.26
chr16_447351_447528 0.08 NME4
 NME/NM23 nucleoside diphosphate kinase 4
 202
 0.88
chr3_43935752_43936459 0.08 ENSG00000252980
 .
 176474
 0.03
chr2_127643626_127643777 0.08 AC114783.1
 Protein LOC339760
 12771
 0.28
chr9_35116014_35116425 0.08 FAM214B
 family with sequence similarity 214, member B
 119
 0.94

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of HIF1A

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0070141 response to UV-A(GO:0070141)
0.0 0.1 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 0.1 GO:0001880 Mullerian duct regression(GO:0001880)
0.0 0.2 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0 0.2 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.1 GO:0071072 negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0 0.1 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.1 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.0 0.1 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:0008215 spermine metabolic process(GO:0008215)
0.0 0.1 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.0 0.2 GO:0007413 axonal fasciculation(GO:0007413)
0.0 0.1 GO:0003085 negative regulation of systemic arterial blood pressure(GO:0003085)
0.0 0.0 GO:0046084 adenine salvage(GO:0006168) purine nucleobase salvage(GO:0043096) adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.0 0.1 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.1 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.0 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.1 GO:0008218 bioluminescence(GO:0008218)
0.0 0.1 GO:0010661 positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0 0.1 GO:0009912 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.0 0.1 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.1 GO:0021569 rhombomere 3 development(GO:0021569)
0.0 0.1 GO:0060586 multicellular organismal iron ion homeostasis(GO:0060586)
0.0 0.1 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0003010 voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0 0.1 GO:0034653 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0 0.1 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.1 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.1 GO:0009136 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0 0.1 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.1 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.1 GO:0002072 optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0 0.3 GO:0046697 decidualization(GO:0046697)
0.0 0.1 GO:0010667 striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0 0.0 GO:0010842 retina layer formation(GO:0010842)
0.0 0.1 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 0.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.1 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.0 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.1 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.0 GO:0043578 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.1 GO:0060535 trachea cartilage development(GO:0060534) trachea cartilage morphogenesis(GO:0060535) cartilage morphogenesis(GO:0060536)
0.0 0.0 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.1 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.1 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.1 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 0.1 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.0 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) maturation of LSU-rRNA(GO:0000470)
0.0 0.1 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.0 0.0 GO:0060430 lung saccule development(GO:0060430) Type II pneumocyte differentiation(GO:0060510)
0.0 0.0 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0 0.1 GO:0060351 cartilage development involved in endochondral bone morphogenesis(GO:0060351)
0.0 0.1 GO:0016264 gap junction assembly(GO:0016264)
0.0 0.1 GO:1903392 negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)
0.0 0.1 GO:0032098 regulation of appetite(GO:0032098)
0.0 0.1 GO:0060638 mesenchymal-epithelial cell signaling(GO:0060638)
0.0 0.0 GO:0051451 myoblast migration(GO:0051451)
0.0 0.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.0 GO:0006498 N-terminal protein lipidation(GO:0006498)
0.0 0.0 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.0 GO:0007412 axon target recognition(GO:0007412)
0.0 0.0 GO:0060596 mammary placode formation(GO:0060596)
0.0 0.0 GO:0032928 regulation of superoxide anion generation(GO:0032928)
0.0 0.0 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.0 0.0 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.0 0.1 GO:0033327 Leydig cell differentiation(GO:0033327)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0030122 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.0 GO:0070062 extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.1 GO:0070761 pre-snoRNP complex(GO:0070761)
0.0 0.0 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.1 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 0.1 GO:0005883 neurofilament(GO:0005883)
0.0 0.0 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.1 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.0 GO:0005593 FACIT collagen trimer(GO:0005593)
0.0 0.1 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.1 GO:0031430 M band(GO:0031430)
0.0 0.1 GO:0005861 troponin complex(GO:0005861)
0.0 0.0 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.0 GO:0043259 laminin-10 complex(GO:0043259)
0.0 0.1 GO:0005587 collagen type IV trimer(GO:0005587)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.1 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 0.2 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0 0.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.1 GO:0070061 fructose binding(GO:0070061)
0.0 0.1 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.1 GO:0016151 nickel cation binding(GO:0016151)
0.0 0.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.1 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.1 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.3 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.1 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.1 GO:0046870 cadmium ion binding(GO:0046870)
0.0 0.1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.1 GO:0031014 troponin T binding(GO:0031014)
0.0 0.1 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.1 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.0 0.1 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.1 GO:0070215 obsolete MDM2 binding(GO:0070215)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)
0.0 0.0 GO:0034617 tetrahydrobiopterin binding(GO:0034617)
0.0 0.0 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.2 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.0 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.0 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.0 0.1 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.0 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.0 0.1 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.1 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 0.0 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.1 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.0 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.0 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.0 0.1 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.0 0.1 GO:0070064 proline-rich region binding(GO:0070064)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.0 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.2 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.4 PID IGF1 PATHWAY IGF1 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 0.4 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.1 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.0 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.1 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.1 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation