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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for HIF1A

Z-value: 0.62

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Transcription factors associated with HIF1A

Gene Symbol	Gene ID	Gene Info
HIF1A Ensembl NCBI GeneCards UniProt	ENSG00000100644.12	HIF1A

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
HIF1A	chr14_62168732_62168883	4467	0.276581	0.58	1.1e-01	Click!
HIF1A	chr14_62171830_62171981	7565	0.249667	0.57	1.1e-01	Click!
HIF1A	chr14_62185926_62186077	21661	0.210863	0.52	1.5e-01	Click!
HIF1A	chr14_62144501_62144652	17682	0.211114	-0.49	1.8e-01	Click!
HIF1A	chr14_62144211_62144362	17972	0.210257	-0.46	2.2e-01	Click!

Activity of the HIF1A motif across conditions

Conditions sorted by the z-value of the HIF1A motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr7_55087325_55087551	0.38	EGFR	epidermal growth factor receptor	627	0.83
chr14_30396439_30396658	0.32	PRKD1	protein kinase D1	300	0.93
chr4_17783154_17783359	0.27	FAM184B	family with sequence similarity 184, member B	121	0.97
chr11_57406082_57406969	0.26	AP000662.4		676	0.5
chr5_131991447_131991948	0.25	AC004041.2		113	0.94
chr3_171918528_171919229	0.24	ENSG00000243398	.	36238	0.18
chr19_46916092_46916684	0.24	CCDC8	coiled-coil domain containing 8	453	0.75
chr12_58120609_58120962	0.23	AGAP2-AS1	AGAP2 antisense RNA 1	731	0.39
chr4_183064801_183065567	0.23	AC108142.1		143	0.83
chr15_95869891_95870263	0.23	ENSG00000222076	.	418956	0.01
chr14_55119300_55119828	0.21	SAMD4A	sterile alpha motif domain containing 4A	84927	0.09
chr5_169172915_169173066	0.21	DOCK2	dedicator of cytokinesis 2	13731	0.24
chr5_83017716_83018280	0.21	HAPLN1	hyaluronan and proteoglycan link protein 1	566	0.78
chr11_35640577_35641198	0.20	FJX1	four jointed box 1 (Drosophila)	1152	0.57
chr15_83875054_83875562	0.19	HDGFRP3	Hepatoma-derived growth factor-related protein 3	1462	0.4
chr18_24764849_24765000	0.19	CHST9	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9	338	0.94
chr5_9546456_9546803	0.19	SEMA5A	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	442	0.8
chrX_107179250_107179655	0.18	RP6-191P20.4		242	0.93
chr17_59476045_59476898	0.17	RP11-332H18.4		260	0.74
chr5_172754207_172754714	0.17	STC2	stanniocalcin 2	596	0.75
chr9_101983648_101983918	0.17	ALG2	ALG2, alpha-1,3/1,6-mannosyltransferase	454	0.53
chr3_141088214_141088426	0.17	RP11-438D8.2		2341	0.33
chr15_23931247_23932124	0.17	NDN	necdin, melanoma antigen (MAGE) family member	765	0.7
chr10_122216113_122216362	0.17	PPAPDC1A	phosphatidic acid phosphatase type 2 domain containing 1A	229	0.95
chr17_7342924_7343492	0.16	FGF11	fibroblast growth factor 11	9	0.91
chr4_93226727_93227337	0.16	GRID2	glutamate receptor, ionotropic, delta 2	1224	0.46
chrX_54385157_54385424	0.16	WNK3	WNK lysine deficient protein kinase 3	215	0.95
chr19_13135793_13135990	0.16	NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	80	0.94
chrX_105969921_105970262	0.15	RNF128	ring finger protein 128, E3 ubiquitin protein ligase	197	0.96
chr14_64804508_64805275	0.15	ESR2	estrogen receptor 2 (ER beta)	61	0.87
chr20_4129930_4130735	0.15	SMOX	spermine oxidase	750	0.71
chr3_159482295_159482916	0.15	IQCJ-SCHIP1	IQCJ-SCHIP1 readthrough	287	0.9
chr16_56660383_56660534	0.15	MT1E	metallothionein 1E	748	0.38
chr6_138571879_138572276	0.15	PBOV1	prostate and breast cancer overexpressed 1	32450	0.2
chr10_13931045_13931263	0.15	FRMD4A	FERM domain containing 4A	30242	0.2
chr14_69013839_69014176	0.15	CTD-2325P2.4		81155	0.1
chrX_48930077_48930476	0.15	PRAF2	PRA1 domain family, member 2	1372	0.22
chr13_37494481_37494632	0.15	SMAD9	SMAD family member 9	147	0.96
chr10_16562894_16563258	0.15	C1QL3	complement component 1, q subcomponent-like 3	928	0.63
chr4_23890359_23890765	0.14	PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	1096	0.66
chr4_115519485_115519837	0.14	UGT8	UDP glycosyltransferase 8	50	0.99
chr7_15725092_15725754	0.14	MEOX2	mesenchyme homeobox 2	1014	0.63
chr3_133646028_133646432	0.14	C3orf36	chromosome 3 open reading frame 36	2426	0.34
chr20_11138132_11138283	0.14	C20orf187	chromosome 20 open reading frame 187	129396	0.06
chr9_133884490_133884806	0.14	LAMC3	laminin, gamma 3	179	0.95
chr3_170137410_170137695	0.14	CLDN11	claudin 11	697	0.77
chr11_2187699_2187850	0.14	TH	tyrosine hydroxylase	1562	0.23
chr7_43152327_43152563	0.14	HECW1	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	201	0.93
chr10_49731531_49732112	0.14	ARHGAP22	Rho GTPase activating protein 22	460	0.85
chr11_119455314_119455975	0.14	RP11-196E1.3		23491	0.19
chr1_158968705_158968932	0.14	IFI16	interferon, gamma-inducible protein 16	940	0.6
chr19_49575534_49575685	0.14	KCNA7	potassium voltage-gated channel, shaker-related subfamily, member 7	589	0.44
chr6_7909475_7910402	0.13	TXNDC5	thioredoxin domain containing 5 (endoplasmic reticulum)	372	0.92
chr6_169653425_169653684	0.13	THBS2	thrombospondin 2	585	0.83
chr1_16399640_16399936	0.13	FAM131C	family with sequence similarity 131, member C	333	0.84
chr15_91500342_91500803	0.13	RCCD1	RCC1 domain containing 1	1546	0.18
chr18_8706613_8707165	0.13	SOGA2	SOGA family member 2	520	0.55
chr7_94536809_94537187	0.13	PPP1R9A	protein phosphatase 1, regulatory subunit 9A	11	0.99
chr19_55591836_55592067	0.13	EPS8L1	EPS8-like 1	191	0.89
chr5_81701799_81702115	0.13	ATP6AP1L	ATPase, H+ transporting, lysosomal accessory protein 1-like	100791	0.08
chr19_53561526_53561765	0.13	ERVV-2	endogenous retrovirus group V, member 2	13654	0.13
chr8_37823203_37823407	0.13	ADRB3	adrenoceptor beta 3	1178	0.39
chr3_62359874_62360076	0.13	FEZF2	FEZ family zinc finger 2	24	0.98
chr14_75389218_75389970	0.13	RPS6KL1	ribosomal protein S6 kinase-like 1	360	0.84
chr9_22005843_22006115	0.12	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	2973	0.2
chr16_22826079_22826361	0.12	HS3ST2	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	722	0.79
chr7_28076392_28076791	0.12	JAZF1	JAZF zinc finger 1	16173	0.26
chr22_43115644_43116713	0.12	A4GALT	alpha 1,4-galactosyltransferase	24539	0.15
chr20_19738276_19738696	0.12	AL121761.2	Uncharacterized protein	193	0.95
chr16_21312757_21313165	0.12	CRYM	crystallin, mu	1411	0.46
chr22_44433690_44434013	0.12	PARVB	parvin, beta	6606	0.26
chr7_47576453_47576928	0.12	TNS3	tensin 3	2185	0.45
chr1_1490221_1490372	0.12	TMEM240	transmembrane protein 240	14463	0.09
chr9_8733649_8733843	0.12	PTPRD	protein tyrosine phosphatase, receptor type, D	148	0.97
chr15_73976688_73977423	0.12	CD276	CD276 molecule	17	0.98
chr2_74968036_74968578	0.11	SEMA4F	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F	86869	0.07
chr11_60609533_60610326	0.11	CCDC86	coiled-coil domain containing 86	385	0.51
chr8_42356526_42357223	0.11	SLC20A2	solute carrier family 20 (phosphate transporter), member 2	1887	0.34
chr5_38846105_38846894	0.11	OSMR	oncostatin M receptor	398	0.91
chr1_16275488_16275712	0.11	ZBTB17	zinc finger and BTB domain containing 17	4677	0.16
chr17_1665908_1666244	0.11	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	47	0.96
chr7_116660327_116660575	0.11	ST7	suppression of tumorigenicity 7	120	0.96
chr20_53092350_53092560	0.11	DOK5	docking protein 5	198	0.97
chr11_133907029_133907299	0.11	JAM3	junctional adhesion molecule 3	31656	0.18
chr7_56183478_56183932	0.11	NUPR1L	nuclear protein, transcriptional regulator, 1-like	388	0.78
chr11_19367315_19367499	0.11	NAV2	neuron navigator 2	4864	0.23
chr6_1381911_1382148	0.11	RP4-668J24.2		3272	0.28
chr15_83316430_83317127	0.11	CPEB1	cytoplasmic polyadenylation element binding protein 1	50	0.76
chr8_15095014_15095265	0.11	SGCZ	sarcoglycan, zeta	709	0.82
chr2_239072349_239072829	0.11	FAM132B	family with sequence similarity 132, member B	385	0.8
chr11_33397614_33397834	0.11	ENSG00000223134	.	21713	0.24
chr20_13976647_13977145	0.11	SEL1L2	sel-1 suppressor of lin-12-like 2 (C. elegans)	193	0.78
chr19_1241899_1242560	0.11	ATP5D	ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit	410	0.68
chr4_142053459_142053770	0.10	RNF150	ring finger protein 150	382	0.92
chr6_54564223_54564374	0.10	ENSG00000251946	.	86887	0.1
chr5_122425011_122425806	0.10	AC106786.1		418	0.57
chr1_17019431_17019582	0.10	ENSG00000264742	.	11756	0.12
chr18_43913317_43913996	0.10	RNF165	ring finger protein 165	275	0.95
chr20_33300382_33300533	0.10	TP53INP2	tumor protein p53 inducible nuclear protein 2	7918	0.22
chr10_5708404_5708555	0.10	ASB13	ankyrin repeat and SOCS box containing 13	62	0.97
chr7_41736310_41736535	0.10	INHBA-AS1	INHBA antisense RNA 1	2876	0.26
chr1_214156478_214156705	0.10	PROX1	prospero homeobox 1	67	0.98
chr19_290704_290961	0.10	PPAP2C	phosphatidic acid phosphatase type 2C	338	0.87
chr4_8271771_8271998	0.10	HTRA3	HtrA serine peptidase 3	380	0.89
chr20_19956104_19956326	0.10	NAA20	N(alpha)-acetyltransferase 20, NatB catalytic subunit	41545	0.15
chr19_44951986_44952721	0.10	ZNF229	zinc finger protein 229	296	0.89
chr13_20751391_20751542	0.10	LINC00556	long intergenic non-protein coding RNA 556	4204	0.21
chr13_114048059_114048366	0.10	GRTP1	growth hormone regulated TBC protein 1	29771	0.13
chr4_17782801_17783007	0.10	FAM184B	family with sequence similarity 184, member B	231	0.94
chr15_75931462_75932480	0.10	IMP3	IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)	581	0.57
chr9_35907347_35908019	0.10	HRCT1	histidine rich carboxyl terminus 1	1494	0.3
chr7_100167546_100168141	0.10	SAP25	Sin3A-associated protein, 25kDa	3427	0.11
chr10_123922760_123923208	0.10	TACC2	transforming, acidic coiled-coil containing protein 2	43	0.99
chr18_24155058_24155571	0.10	ENSG00000252846	.	11448	0.22
chr8_143695363_143695514	0.10	ARC	activity-regulated cytoskeleton-associated protein	1395	0.35
chr13_44947783_44948184	0.10	SERP2	stress-associated endoplasmic reticulum protein family member 2	5	0.99
chr1_31480017_31480289	0.10	PUM1	pumilio RNA-binding family member 1	12202	0.19
chr4_124426780_124427488	0.10	SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	106011	0.08
chr9_101469729_101470145	0.10	GABBR2	gamma-aminobutyric acid (GABA) B receptor, 2	1542	0.5
chr9_130330127_130331202	0.10	FAM129B	family with sequence similarity 129, member B	703	0.67
chr2_242742783_242743231	0.10	AC114730.5		1685	0.21
chr12_48513521_48513903	0.10	PFKM	phosphofructokinase, muscle	142	0.94
chr9_111205795_111206154	0.10	ENSG00000222512	.	84765	0.11
chr2_5831543_5831945	0.09	AC107057.2		124	0.83
chr5_180669462_180669613	0.09	GNB2L1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	291	0.58
chr16_65154751_65155029	0.09	CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	943	0.75
chrX_12156590_12157176	0.09	FRMPD4	FERM and PDZ domain containing 4	298	0.9
chr18_22930019_22930221	0.09	ZNF521	zinc finger protein 521	1037	0.66
chr2_242157667_242157840	0.09	ANO7	anoctamin 7	723	0.57
chr9_136857518_136857728	0.09	VAV2	vav 2 guanine nucleotide exchange factor	103	0.97
chr14_72231475_72231648	0.09	SIPA1L1	signal-induced proliferation-associated 1 like 1	146088	0.04
chr19_3367591_3367973	0.09	NFIC	nuclear factor I/C (CCAAT-binding transcription factor)	1198	0.48
chr6_28456937_28457274	0.09	GPX6	glutathione peroxidase 6 (olfactory)	26459	0.14
chr15_44486029_44486998	0.09	FRMD5	FERM domain containing 5	131	0.98
chr5_42424322_42424771	0.09	GHR	growth hormone receptor	520	0.88
chr2_220283280_220283537	0.09	DES	desmin	309	0.8
chr16_2835054_2835205	0.09	PRSS33	protease, serine, 33	1477	0.19
chr5_11384809_11385052	0.09	CTNND2	catenin (cadherin-associated protein), delta 2	203993	0.03
chr13_53174146_53174487	0.09	HNRNPA1L2	heterogeneous nuclear ribonucleoprotein A1-like 2	17289	0.22
chr6_85483496_85483916	0.09	TBX18	T-box 18	9469	0.3
chr12_3069053_3070004	0.09	TEAD4	TEA domain family member 4	445	0.77
chr1_159924191_159924342	0.09	SLAMF9	SLAM family member 9	222	0.88
chr10_123357016_123357770	0.09	FGFR2	fibroblast growth factor receptor 2	205	0.97
chr1_55436937_55437088	0.09	TMEM61	transmembrane protein 61	9453	0.16
chr11_11642193_11642674	0.09	GALNT18	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18	1119	0.56
chr3_42922021_42922670	0.09	CYP8B1	cytochrome P450, family 8, subfamily B, polypeptide 1	4712	0.15
chrX_48693575_48693797	0.09	PCSK1N	proprotein convertase subtilisin/kexin type 1 inhibitor	349	0.78
chr18_31802690_31803001	0.09	RP11-379L18.1		84	0.8
chr13_97646306_97646561	0.09	OXGR1	oxoglutarate (alpha-ketoglutarate) receptor 1	171	0.96
chr7_128045105_128045914	0.09	IMPDH1	IMP (inosine 5'-monophosphate) dehydrogenase 1	487	0.75
chr3_44040787_44041403	0.09	ENSG00000252980	.	71484	0.12
chr19_36036432_36037158	0.09	AD000090.2		136	0.59
chr10_81741543_81742003	0.09	SFTPD	surfactant protein D	597	0.81
chr1_41961804_41962136	0.09	EDN2	endothelin 2	11628	0.2
chr2_73518392_73518872	0.09	EGR4	early growth response 4	2197	0.23
chr5_9547808_9548146	0.09	ENSG00000239112	.	971	0.49
chr5_6449023_6449402	0.09	UBE2QL1	ubiquitin-conjugating enzyme E2Q family-like 1	476	0.88
chr2_239756978_239757253	0.09	TWIST2	twist family bHLH transcription factor 2	442	0.88
chr4_54966297_54966506	0.09	GSX2	GS homeobox 2	61	0.97
chr1_230222759_230222910	0.08	GALNT2	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	19816	0.23
chr1_8074798_8074959	0.08	ERRFI1	ERBB receptor feedback inhibitor 1	815	0.65
chr13_93879365_93880233	0.08	GPC6	glypican 6	704	0.82
chr13_27936373_27936791	0.08	ENSG00000252247	.	18699	0.15
chr6_1611333_1611591	0.08	FOXC1	forkhead box C1	781	0.77
chr2_240169087_240169238	0.08	HDAC4	histone deacetylase 4	56410	0.1
chr3_44803922_44804142	0.08	KIF15	kinesin family member 15	678	0.45
chr3_48722741_48723287	0.08	NCKIPSD	NCK interacting protein with SH3 domain	254	0.86
chr16_48570079_48570232	0.08	RP11-44I10.3		23417	0.17
chr1_92495646_92496322	0.08	EPHX4	epoxide hydrolase 4	445	0.85
chr11_70244216_70245100	0.08	CTTN	cortactin	11	0.53
chr6_28574388_28574671	0.08	SCAND3	SCAN domain containing 3	19417	0.18
chr6_84139529_84139855	0.08	ME1	malic enzyme 1, NADP(+)-dependent, cytosolic	1072	0.62
chr4_157862974_157863267	0.08	PDGFC	platelet derived growth factor C	28935	0.19
chr5_150325496_150325780	0.08	ZNF300P1	zinc finger protein 300 pseudogene 1	213	0.94
chr17_40932934_40933198	0.08	WNK4	WNK lysine deficient protein kinase 4	370	0.71
chr19_17422589_17422876	0.08	ABHD8	abhydrolase domain containing 8	1687	0.15
chrX_114467670_114468385	0.08	LRCH2	leucine-rich repeats and calponin homology (CH) domain containing 2	601	0.77
chr9_116918690_116918954	0.08	COL27A1	collagen, type XXVII, alpha 1	982	0.6
chr18_70534206_70534360	0.08	NETO1	neuropilin (NRP) and tolloid (TLL)-like 1	17	0.98
chr21_35348616_35348984	0.08	LINC00649	long intergenic non-protein coding RNA 649	6980	0.21
chr19_16179581_16179939	0.08	TPM4	tropomyosin 4	1250	0.44
chr17_8533666_8534137	0.08	MYH10	myosin, heavy chain 10, non-muscle	134	0.97
chr13_21295723_21296224	0.08	ENSG00000265710	.	18131	0.18
chr19_55658159_55658310	0.08	TNNT1	troponin T type 1 (skeletal, slow)	76	0.93
chr14_105965982_105966133	0.08	C14orf80	chromosome 14 open reading frame 80	8326	0.11
chr8_23711375_23711668	0.08	STC1	stanniocalcin 1	303	0.92
chr10_134581493_134581644	0.08	INPP5A	inositol polyphosphate-5-phosphatase, 40kDa	2240	0.34
chr4_154149984_154150203	0.08	TRIM2	tripartite motif containing 2	24475	0.17
chr6_160769471_160769667	0.08	SLC22A3	solute carrier family 22 (organic cation transporter), member 3	144	0.98
chr5_15500636_15500842	0.08	FBXL7	F-box and leucine-rich repeat protein 7	434	0.91
chr20_9048816_9049419	0.08	PLCB4	phospholipase C, beta 4	293	0.9
chr21_35319646_35320126	0.08	LINC00649	long intergenic non-protein coding RNA 649	1144	0.46
chr5_343986_344609	0.08	AHRR	aryl-hydrocarbon receptor repressor	654	0.71
chr11_65666966_65667198	0.08	FOSL1	FOS-like antigen 1	808	0.38
chr22_39638932_39639142	0.08	PDGFB	platelet-derived growth factor beta polypeptide	16	0.97
chr15_63664855_63665177	0.08	CA12	carbonic anhydrase XII	9018	0.26
chr16_447351_447528	0.08	NME4	NME/NM23 nucleoside diphosphate kinase 4	202	0.88
chr3_43935752_43936459	0.08	ENSG00000252980	.	176474	0.03
chr2_127643626_127643777	0.08	AC114783.1	Protein LOC339760	12771	0.28
chr9_35116014_35116425	0.08	FAM214B	family with sequence similarity 214, member B	119	0.94

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HIF1A

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0070141	response to UV-A(GO:0070141)
0.0	0.1	GO:0070309	lens fiber cell morphogenesis(GO:0070309)
0.0	0.1	GO:0001880	Mullerian duct regression(GO:0001880)
0.0	0.2	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0	0.2	GO:0032808	lacrimal gland development(GO:0032808)
0.0	0.1	GO:0071072	negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.1	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.1	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.1	GO:0045578	negative regulation of B cell differentiation(GO:0045578)
0.0	0.2	GO:0007413	axonal fasciculation(GO:0007413)
0.0	0.1	GO:0003085	negative regulation of systemic arterial blood pressure(GO:0003085)
0.0	0.0	GO:0046084	adenine salvage(GO:0006168) purine nucleobase salvage(GO:0043096) adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.0	0.1	GO:0000491	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.1	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0	0.0	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.1	GO:0008218	bioluminescence(GO:0008218)
0.0	0.1	GO:0010661	positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0	0.1	GO:0009912	auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.0	0.1	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.1	GO:0021569	rhombomere 3 development(GO:0021569)
0.0	0.1	GO:0060586	multicellular organismal iron ion homeostasis(GO:0060586)
0.0	0.1	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.1	GO:0003010	voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0	0.1	GO:0034653	diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0	0.1	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.1	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.1	GO:0009136	ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0	0.1	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0	0.1	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.1	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0	0.3	GO:0046697	decidualization(GO:0046697)
0.0	0.1	GO:0010667	striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0	0.0	GO:0010842	retina layer formation(GO:0010842)
0.0	0.1	GO:0030970	retrograde protein transport, ER to cytosol(GO:0030970)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.1	GO:0043249	erythrocyte maturation(GO:0043249)
0.0	0.0	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.1	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.0	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0060535	trachea cartilage development(GO:0060534) trachea cartilage morphogenesis(GO:0060535) cartilage morphogenesis(GO:0060536)
0.0	0.0	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.0	0.1	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.1	GO:0006177	GMP biosynthetic process(GO:0006177)
0.0	0.1	GO:0055003	cardiac myofibril assembly(GO:0055003)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.0	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) maturation of LSU-rRNA(GO:0000470)
0.0	0.1	GO:0060052	neurofilament cytoskeleton organization(GO:0060052)
0.0	0.0	GO:0060430	lung saccule development(GO:0060430) Type II pneumocyte differentiation(GO:0060510)
0.0	0.0	GO:0046022	regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0	0.1	GO:0060351	cartilage development involved in endochondral bone morphogenesis(GO:0060351)
0.0	0.1	GO:0016264	gap junction assembly(GO:0016264)
0.0	0.1	GO:1903392	negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)
0.0	0.1	GO:0032098	regulation of appetite(GO:0032098)
0.0	0.1	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.0	GO:0051451	myoblast migration(GO:0051451)
0.0	0.1	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.0	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	0.0	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.0	GO:0007412	axon target recognition(GO:0007412)
0.0	0.0	GO:0060596	mammary placode formation(GO:0060596)
0.0	0.0	GO:0032928	regulation of superoxide anion generation(GO:0032928)
0.0	0.0	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.0	0.0	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.1	GO:0033327	Leydig cell differentiation(GO:0033327)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.3	GO:0030122	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.1	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.1	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.1	GO:0030934	anchoring collagen complex(GO:0030934)
0.1	GO:0043202	lysosomal lumen(GO:0043202)
0.0	GO:0070062	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.1	GO:0016012	sarcoglycan complex(GO:0016012)
0.1	GO:0070761	pre-snoRNP complex(GO:0070761)
0.0	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.1	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.1	GO:0005883	neurofilament(GO:0005883)
0.0	GO:0070545	PeBoW complex(GO:0070545)
0.1	GO:0005652	nuclear lamina(GO:0005652)
0.0	GO:0005593	FACIT collagen trimer(GO:0005593)
0.1	GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1	GO:0031430	M band(GO:0031430)
0.1	GO:0005861	troponin complex(GO:0005861)
0.0	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	GO:0043259	laminin-10 complex(GO:0043259)
0.1	GO:0005587	collagen type IV trimer(GO:0005587)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.2	GO:0001537	N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0070061	fructose binding(GO:0070061)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.1	GO:0000033	alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0	0.1	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.2	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.1	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.3	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.1	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.1	GO:0046870	cadmium ion binding(GO:0046870)
0.0	0.1	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.1	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.1	GO:0031014	troponin T binding(GO:0031014)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.1	GO:0050698	proteoglycan sulfotransferase activity(GO:0050698)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.1	GO:0070215	obsolete MDM2 binding(GO:0070215)
0.0	0.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.0	GO:0034617	tetrahydrobiopterin binding(GO:0034617)
0.0	0.0	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.2	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	0.0	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.0	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.0	GO:0004500	dopamine beta-monooxygenase activity(GO:0004500)
0.0	0.1	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.0	GO:0016615	malate dehydrogenase activity(GO:0016615)
0.0	0.1	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.0	0.1	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.0	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0	0.1	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0	0.0	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.0	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0008504	monoamine transmembrane transporter activity(GO:0008504)
0.0	0.1	GO:0070064	proline-rich region binding(GO:0070064)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.2	PID ALK2 PATHWAY	ALK2 signaling events
0.4	PID IGF1 PATHWAY	IGF1 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.0	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.4	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.1	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	REACTOME FGFR1 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR1 ligand binding and activation
0.1	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.3	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.1	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation