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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for HMGA2

Z-value: 0.56

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Transcription factors associated with HMGA2

Gene Symbol	Gene ID	Gene Info
HMGA2 Ensembl NCBI GeneCards UniProt	ENSG00000149948.9	HMGA2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
HMGA2	chr12_66159147_66159298	58689	0.133634	0.81	8.2e-03	Click!
HMGA2	chr12_66198631_66198915	19138	0.213991	0.62	7.4e-02	Click!
HMGA2	chr12_66219476_66219782	726	0.709628	0.62	7.7e-02	Click!
HMGA2	chr12_66198930_66199081	18906	0.214328	0.62	7.8e-02	Click!
HMGA2	chr12_66048530_66048681	169306	0.033135	0.62	7.8e-02	Click!

Activity of the HMGA2 motif across conditions

Conditions sorted by the z-value of the HMGA2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr20_52271481_52272252	0.31	ENSG00000238468	.	13431	0.22
chr6_17986477_17986974	0.24	KIF13A	kinesin family member 13A	969	0.69
chr8_53851583_53851734	0.21	NPBWR1	neuropeptides B/W receptor 1	667	0.79
chr2_147579520_147579813	0.21	ENSG00000238860	.	501873	0.0
chr2_26100038_26101197	0.21	ASXL2	additional sex combs like 2 (Drosophila)	718	0.76
chr4_15908125_15908316	0.20	FGFBP1	fibroblast growth factor binding protein 1	31751	0.17
chr5_171380881_171381289	0.19	FBXW11	F-box and WD repeat domain containing 11	23675	0.23
chr18_53255518_53256419	0.18	TCF4	transcription factor 4	108	0.98
chr7_32929941_32930760	0.18	KBTBD2	kelch repeat and BTB (POZ) domain containing 2	415	0.87
chr17_79371776_79372295	0.18	RP11-1055B8.7	BAH and coiled-coil domain-containing protein 1	1505	0.24
chr4_95469395_95469810	0.17	PDLIM5	PDZ and LIM domain 5	24726	0.27
chr3_153037931_153038307	0.17	ENSG00000265813	.	120313	0.06
chr5_139968434_139968585	0.17	ENSG00000200235	.	9257	0.08
chr10_114714851_114715858	0.16	RP11-57H14.2		3720	0.26
chr2_188418561_188419245	0.16	AC007319.1		27	0.69
chr12_22005080_22005298	0.16	RP11-729I10.2		25045	0.19
chr20_14310710_14310861	0.16	FLRT3	fibronectin leucine rich transmembrane protein 3	7469	0.25
chr3_27765284_27765702	0.15	EOMES	eomesodermin	1287	0.62
chr18_42288728_42289100	0.15	SETBP1	SET binding protein 1	11785	0.32
chr9_111773050_111773591	0.15	CTNNAL1	catenin (cadherin-associated protein), alpha-like 1	2459	0.23
chr3_174819626_174819777	0.15	ENSG00000230292	.	13331	0.3
chr5_58571069_58571855	0.15	PDE4D	phosphodiesterase 4D, cAMP-specific	483	0.9
chr19_6076628_6076815	0.15	CTC-232P5.3		8757	0.15
chr4_32149379_32149669	0.15	NA	NA	> 10⁶	NA
chr2_198146440_198146591	0.15	ANKRD44-IT1	ANKRD44 intronic transcript 1 (non-protein coding)	20728	0.16
chr10_33552568_33552719	0.15	NRP1	neuropilin 1	11	0.98
chr7_117919021_117919172	0.15	ANKRD7	ankyrin repeat domain 7	54145	0.17
chr5_34609228_34609529	0.15	RAI14	retinoic acid induced 14	46964	0.16
chr3_99544366_99544517	0.15	CMSS1	cms1 ribosomal small subunit homolog (yeast)	7760	0.24
chr2_40049399_40049550	0.15	SLC8A1-AS1	SLC8A1 antisense RNA 1	35881	0.19
chr2_238732566_238732717	0.15	RBM44	RNA binding motif protein 44	24820	0.17
chr6_98074983_98075489	0.15	MMS22L	MMS22-like, DNA repair protein	344184	0.01
chr5_153424892_153425043	0.15	MFAP3	microfibrillar-associated protein 3	6408	0.22
chr11_37276640_37276791	0.14	ENSG00000251838	.	447055	0.01
chr4_157996824_157996975	0.14	GLRB	glycine receptor, beta	310	0.91
chr10_98433378_98434045	0.14	PIK3AP1	phosphoinositide-3-kinase adaptor protein 1	4343	0.25
chr6_84139529_84139855	0.14	ME1	malic enzyme 1, NADP(+)-dependent, cytosolic	1072	0.62
chr2_106886104_106886958	0.14	UXS1	UDP-glucuronate decarboxylase 1	75736	0.1
chr4_139162325_139164249	0.14	SLC7A11	solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11	216	0.97
chr16_83860165_83860316	0.14	HSBP1	heat shock factor binding protein 1	18646	0.15
chr10_5723817_5723968	0.14	FAM208B	family with sequence similarity 208, member B	2909	0.23
chr9_128511491_128511642	0.14	PBX3	pre-B-cell leukemia homeobox 3	1088	0.62
chr10_17241830_17242242	0.14	TRDMT1	tRNA aspartic acid methyltransferase 1	1543	0.37
chr14_51421850_51422001	0.14	PYGL	phosphorylase, glycogen, liver	10471	0.2
chr1_206685685_206685836	0.14	RASSF5	Ras association (RalGDS/AF-6) domain family member 5	4881	0.16
chr12_31470154_31471349	0.14	FAM60A	family with sequence similarity 60, member A	6345	0.16
chr6_27515697_27516098	0.14	ENSG00000206671	.	48294	0.13
chr6_143140776_143141820	0.14	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	16886	0.26
chr12_29716327_29716478	0.13	TMTC1	transmembrane and tetratricopeptide repeat containing 1	40755	0.16
chr4_175135836_175136127	0.13	FBXO8	F-box protein 8	68833	0.12
chr4_157729119_157729270	0.13	RP11-154F14.2		33317	0.19
chr13_40081557_40081708	0.13	ENSG00000238408	.	60279	0.13
chr11_22380798_22380949	0.13	CTD-2140G10.4		2967	0.27
chr8_13909602_13909753	0.13	RP11-3G21.1		109129	0.07
chr9_109668731_109668882	0.13	RP11-508N12.4	Uncharacterized protein	16824	0.21
chr5_64543321_64543472	0.13	ENSG00000207439	.	124200	0.06
chr9_95590209_95590360	0.13	ENSG00000252772	.	7025	0.17
chr2_230148069_230148220	0.13	PID1	phosphotyrosine interaction domain containing 1	12143	0.27
chr1_209528208_209528359	0.13	ENSG00000230937	.	77195	0.12
chrX_2670582_2670733	0.13	XG	Xg blood group	471	0.83
chr10_75938020_75938413	0.13	ADK	adenosine kinase	1695	0.42
chr3_32282148_32282299	0.13	CMTM8	CKLF-like MARVEL transmembrane domain containing 8	2052	0.26
chr3_28025237_28025388	0.13	CMC1	C-x(9)-C motif containing 1	257774	0.02
chr1_207489819_207490027	0.13	CD55	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	4930	0.3
chr13_24782412_24782563	0.13	SPATA13	spermatogenesis associated 13	43345	0.13
chr9_22006120_22006693	0.13	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	2546	0.22
chr8_131206670_131206845	0.12	ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	13649	0.23
chr12_94134651_94134921	0.12	RP11-887P2.5		3187	0.3
chr13_80913239_80913578	0.12	SPRY2	sprouty homolog 2 (Drosophila)	386	0.91
chr21_47064838_47064989	0.12	PCBP3	poly(rC) binding protein 3	1305	0.55
chr1_158150876_158151479	0.12	CD1D	CD1d molecule	1440	0.48
chr12_109344609_109344760	0.12	ENSG00000201324	.	24367	0.14
chr1_1259044_1259204	0.12	CPSF3L	cleavage and polyadenylation specific factor 3-like	865	0.26
chr10_119132010_119132432	0.12	PDZD8	PDZ domain containing 8	2757	0.3
chr10_6779919_6780270	0.12	PRKCQ	protein kinase C, theta	157831	0.04
chr17_27048575_27048801	0.12	ENSG00000238578	.	912	0.15
chr11_122177788_122178312	0.12	RP11-716H6.2		12152	0.26
chr1_27809144_27809295	0.12	WASF2	WAS protein family, member 2	7343	0.18
chr1_40358588_40359026	0.12	RP1-118J21.5		4610	0.14
chr5_16701908_16702059	0.12	MYO10	myosin X	36513	0.17
chr19_1747120_1747271	0.12	ONECUT3	one cut homeobox 3	5177	0.15
chr16_13401641_13401792	0.12	AC003009.1		24724	0.26
chr14_85882041_85882312	0.12	RP11-497E19.2	Uncharacterized protein	112767	0.07
chr19_45147190_45148055	0.12	PVR	poliovirus receptor	225	0.9
chr8_61432570_61432721	0.12	RAB2A	RAB2A, member RAS oncogene family	2905	0.3
chr17_64464860_64465690	0.12	RP11-4F22.2		52303	0.15
chr6_163838395_163838889	0.12	QKI	QKI, KH domain containing, RNA binding	1295	0.63
chr16_48611180_48611331	0.12	RP11-44I10.3		17683	0.18
chr21_34800838_34800989	0.12	IFNGR2	interferon gamma receptor 2 (interferon gamma transducer 1)	3713	0.19
chr2_58654566_58655399	0.12	FANCL	Fanconi anemia, complementation group L	186475	0.03
chr1_210473057_210473208	0.12	HHAT	hedgehog acyltransferase	28464	0.19
chrX_10587307_10587547	0.12	MID1	midline 1 (Opitz/BBB syndrome)	1032	0.65
chr2_65889672_65889956	0.12	ENSG00000265899	.	4576	0.32
chr1_226846201_226846352	0.11	ITPKB-IT1	ITPKB intronic transcript 1 (non-protein coding)	1095	0.55
chrX_154300630_154300860	0.11	BRCC3	BRCA1/BRCA2-containing complex, subunit 3	941	0.32
chr18_26737213_26737364	0.11	ENSG00000212085	.	39204	0.19
chr4_75481668_75481819	0.11	AREGB	amphiregulin B	1114	0.52
chr4_149087230_149087381	0.11	RP11-76G10.1		19683	0.29
chr5_58830530_58830681	0.11	PDE4D	phosphodiesterase 4D, cAMP-specific	51614	0.19
chr4_75311912_75312063	0.11	AREG	amphiregulin	968	0.58
chr13_38920865_38921016	0.11	UFM1	ubiquitin-fold modifier 1	3048	0.41
chr16_74670457_74670608	0.11	GLG1	golgi glycoprotein 1	29520	0.15
chr9_86955099_86955250	0.11	SLC28A3	solute carrier family 28 (concentrative nucleoside transporter), member 3	424	0.9
chr4_83290764_83291010	0.11	HNRNPD	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	3416	0.22
chr1_186798918_186799215	0.11	PLA2G4A	phospholipase A2, group IVA (cytosolic, calcium-dependent)	944	0.73
chr7_12981455_12981606	0.11	ENSG00000222974	.	65221	0.15
chrY_2620597_2620748	0.11	ENSG00000251841	.	32118	0.19
chr12_123377992_123378152	0.11	VPS37B	vacuolar protein sorting 37 homolog B (S. cerevisiae)	2602	0.24
chr9_72726451_72726602	0.11	MAMDC2-AS1	MAMDC2 antisense RNA 1	2250	0.38
chr15_27536252_27536403	0.11	ENSG00000200326	.	10744	0.21
chr15_71035707_71036127	0.11	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	19852	0.21
chr5_58592476_58593460	0.11	PDE4D	phosphodiesterase 4D, cAMP-specific	21023	0.29
chr3_132316510_132316661	0.11	ACKR4	atypical chemokine receptor 4	504	0.83
chr1_68695889_68696040	0.11	WLS	wntless Wnt ligand secretion mediator	1406	0.51
chr4_54458245_54458396	0.11	LNX1	ligand of numb-protein X 1, E3 ubiquitin protein ligase	388	0.72
chr6_27647378_27647849	0.11	ENSG00000238648	.	48425	0.11
chr7_87503109_87503295	0.11	DBF4	DBF4 homolog (S. cerevisiae)	2342	0.29
chr1_108230763_108230914	0.11	VAV3	vav 3 guanine nucleotide exchange factor	288	0.95
chr15_99416784_99417194	0.11	IGF1R	insulin-like growth factor 1 receptor	16581	0.2
chr9_684288_685148	0.11	RP11-130C19.3		837	0.67
chr9_19377459_19377736	0.11	RP11-513M16.8		2148	0.21
chr14_91337609_91337760	0.10	TTC7B	tetratricopeptide repeat domain 7B	54861	0.15
chr10_116055069_116055220	0.10	VWA2	von Willebrand factor A domain containing 2	56055	0.13
chr16_14398873_14399280	0.10	ENSG00000207639	.	1252	0.44
chr5_76112526_76112677	0.10	F2RL1	coagulation factor II (thrombin) receptor-like 1	2157	0.27
chr12_54090350_54090675	0.10	CALCOCO1	calcium binding and coiled-coil domain 1	17901	0.15
chr14_85999097_85999705	0.10	FLRT2	fibronectin leucine rich transmembrane protein 2	2829	0.32
chr1_151432125_151432340	0.10	POGZ	pogo transposable element with ZNF domain	291	0.85
chr6_86303657_86304481	0.10	SNX14	sorting nexin 14	195	0.95
chr1_152475138_152475289	0.10	LCE5A	late cornified envelope 5A	8107	0.15
chr15_59642585_59642838	0.10	ENSG00000199512	.	9095	0.13
chr6_160209552_160210274	0.10	TCP1	t-complex 1	13	0.95
chr13_62634734_62634885	0.10	ENSG00000212007	.	300300	0.01
chr7_33080072_33080440	0.10	NT5C3A	5'-nucleotidase, cytosolic IIIA	265	0.9
chr6_56517425_56517576	0.10	DST	dystonin	9706	0.31
chr19_14630525_14630676	0.10	DNAJB1	DnaJ (Hsp40) homolog, subfamily B, member 1	1368	0.27
chr18_52988378_52989650	0.10	TCF4	transcription factor 4	203	0.97
chr10_21807539_21808360	0.10	SKIDA1	SKI/DACH domain containing 1	1101	0.4
chr8_1942200_1942351	0.10	KBTBD11	kelch repeat and BTB (POZ) domain containing 11	20231	0.23
chr5_150477046_150477197	0.10	TNIP1	TNFAIP3 interacting protein 1	3983	0.23
chr13_80916504_80917060	0.10	SPRY2	sprouty homolog 2 (Drosophila)	1696	0.48
chr7_25902294_25902669	0.10	ENSG00000199085	.	87125	0.1
chr5_179495571_179495863	0.10	RNF130	ring finger protein 130	3004	0.28
chr19_46957215_46957366	0.10	PNMAL1	paraneoplastic Ma antigen family-like 1	17374	0.12
chr2_72463375_72463664	0.10	CYP26B1	cytochrome P450, family 26, subfamily B, polypeptide 1	88352	0.11
chr2_135676446_135677712	0.10	CCNT2	cyclin T2	684	0.48
chr2_187354223_187354374	0.10	ZC3H15	zinc finger CCCH-type containing 15	3318	0.24
chr4_178495229_178495380	0.10	ENSG00000221499	.	29586	0.22
chr1_70608576_70608727	0.10	ENSG00000244389	.	37472	0.16
chr13_103424804_103424955	0.10	TEX30	testis expressed 30	1226	0.34
chr2_101945321_101945472	0.10	ENSG00000264857	.	19484	0.16
chr10_122725495_122725646	0.10	RP11-95I16.4		85391	0.1
chr16_65566073_65566543	0.10	CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	410040	0.01
chr4_157502928_157503125	0.10	RP11-171N4.2	Uncharacterized protein	60433	0.14
chr3_1830304_1830455	0.10	ENSG00000223040	.	300516	0.01
chr3_189743937_189744088	0.10	ENSG00000265045	.	87711	0.08
chr7_20372921_20373226	0.10	CTA-293F17.1		1703	0.35
chr12_53785686_53785892	0.10	SP1	Sp1 transcription factor	10703	0.12
chr7_129425019_129425280	0.10	ENSG00000207691	.	10295	0.15
chr20_47440971_47441122	0.10	PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	3374	0.34
chr2_178187990_178188141	0.10	AC074286.1		173	0.92
chr22_29280779_29281052	0.10	ZNRF3	zinc and ring finger 3	1025	0.55
chr4_127698376_127698531	0.10	ENSG00000199862	.	250921	0.02
chr6_152085356_152085807	0.10	ESR1	estrogen receptor 1	39985	0.18
chr3_47822404_47822881	0.10	SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	765	0.62
chr20_35120205_35120468	0.10	DLGAP4	discs, large (Drosophila) homolog-associated protein 4	30186	0.14
chr9_33080885_33081164	0.10	SMU1	smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)	4359	0.2
chr17_59534634_59534785	0.10	TBX4	T-box 4	902	0.53
chr5_114970068_114970545	0.10	TMED7	transmembrane emp24 protein transport domain containing 7	1617	0.33
chr3_18418529_18418680	0.10	RP11-158G18.1		32523	0.19
chr6_98566372_98566523	0.10	ENSG00000238367	.	94040	0.1
chr11_12824646_12824913	0.10	RP11-47J17.3		20435	0.2
chr12_84188120_84188271	0.10	ENSG00000221148	.	389032	0.01
chr15_62599027_62599178	0.10	RP11-299H22.5		36223	0.17
chr1_164652386_164652537	0.10	RP11-477H21.2		3139	0.29
chr5_149857239_149857390	0.10	NDST1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	8067	0.18
chr16_82172666_82172817	0.10	RP11-510J16.5		495	0.79
chr6_28175291_28175856	0.10	ZSCAN9	zinc finger and SCAN domain containing 9	17091	0.12
chr15_61963769_61963920	0.09	ENSG00000266349	.	72296	0.13
chr3_107806842_107807168	0.09	CD47	CD47 molecule	2856	0.4
chr3_142607235_142608274	0.09	PCOLCE2	procollagen C-endopeptidase enhancer 2	13	0.98
chr10_33251129_33251359	0.09	ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	967	0.68
chr11_93123532_93123683	0.09	CCDC67	coiled-coil domain containing 67	6973	0.23
chr1_10511739_10511890	0.09	CORT	cortistatin	1843	0.2
chr20_52516714_52516865	0.09	AC005220.3		39910	0.19
chr5_142585460_142585745	0.09	ARHGAP26	Rho GTPase activating protein 26	1161	0.58
chr10_103813684_103813835	0.09	C10orf76	chromosome 10 open reading frame 76	2191	0.26
chr2_212272854_212273005	0.09	ENSG00000199585	.	127449	0.06
chr1_152010543_152010714	0.09	S100A11	S100 calcium binding protein A11	1117	0.44
chr22_36233928_36234199	0.09	RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	2202	0.43
chr1_10124465_10124616	0.09	UBE4B	ubiquitination factor E4B	30886	0.14
chr4_120987081_120987232	0.09	RP11-679C8.2		957	0.45
chr17_75128680_75128831	0.09	SEC14L1	SEC14-like 1 (S. cerevisiae)	4800	0.22
chr5_38854613_38854764	0.09	OSMR	oncostatin M receptor	8587	0.28
chrX_31477449_31477600	0.09	ENSG00000252903	.	111215	0.07
chr14_89507425_89507846	0.09	FOXN3	forkhead box N3	139453	0.05
chr1_158123360_158123511	0.09	CD1D	CD1d molecule	26302	0.19
chr9_75566785_75567046	0.09	ALDH1A1	aldehyde dehydrogenase 1 family, member A1	1056	0.7
chr21_38081043_38081194	0.09	SIM2	single-minded family bHLH transcription factor 2	363	0.88
chr7_18549761_18549974	0.09	HDAC9	histone deacetylase 9	931	0.71

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HMGA2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.2	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.2	GO:0060437	lung growth(GO:0060437)
0.0	0.1	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.2	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.1	GO:0060013	righting reflex(GO:0060013)
0.0	0.1	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.0	0.1	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.1	GO:0042253	granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0042253)
0.0	0.1	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.1	GO:0048003	antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003)
0.0	0.1	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.1	GO:0050923	regulation of negative chemotaxis(GO:0050923)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.1	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0	0.1	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.1	GO:0009215	purine deoxyribonucleoside triphosphate metabolic process(GO:0009215)
0.0	0.1	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.1	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0	0.1	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.1	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.1	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.0	0.0	GO:0051570	regulation of histone H3-K9 methylation(GO:0051570)
0.0	0.0	GO:0072047	proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.0	0.0	GO:0045578	negative regulation of B cell differentiation(GO:0045578)
0.0	0.1	GO:0090116	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.0	GO:0060585	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0	0.0	GO:0043497	regulation of protein heterodimerization activity(GO:0043497)
0.0	0.0	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.1	GO:0016264	gap junction assembly(GO:0016264)
0.0	0.0	GO:0097709	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0	0.1	GO:0042753	positive regulation of circadian rhythm(GO:0042753)
0.0	0.1	GO:0014050	negative regulation of glutamate secretion(GO:0014050)
0.0	0.0	GO:0043302	positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of leukocyte degranulation(GO:0043302) positive regulation of mast cell degranulation(GO:0043306)
0.0	0.0	GO:0002097	tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) tRNA thio-modification(GO:0034227)
0.0	0.0	GO:0021910	smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910)
0.0	0.1	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.0	GO:1903170	negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0	0.0	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.0	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.1	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.0	GO:0090267	positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.0	0.1	GO:0006067	ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0	0.0	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.1	GO:0005916	fascia adherens(GO:0005916)
0.0	GO:0031932	TORC2 complex(GO:0031932)
0.0	GO:0005826	actomyosin contractile ring(GO:0005826)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0001098	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.2	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.2	GO:0004985	opioid receptor activity(GO:0004985)
0.0	0.1	GO:0005415	nucleoside:sodium symporter activity(GO:0005415)
0.0	0.2	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.2	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.1	GO:0016934	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0	0.1	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.0	0.1	GO:0001601	peptide YY receptor activity(GO:0001601)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.1	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.1	GO:0016362	activin receptor activity, type II(GO:0016362)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.1	GO:0050682	AF-2 domain binding(GO:0050682)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.2	GO:0004622	lysophospholipase activity(GO:0004622)
0.0	0.0	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.0	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.0	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.1	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.0	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.0	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.0	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.0	GO:0070053	thrombospondin receptor activity(GO:0070053)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.2	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.0	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.1	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.2	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.2	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.3	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.3	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis