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ENCODE: H3K4me3 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for HOXA2_HOXB1

Z-value: 0.40

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Transcription factors associated with HOXA2_HOXB1

Gene Symbol	Gene ID	Gene Info
HOXA2 Ensembl NCBI GeneCards UniProt	ENSG00000105996.5	HOXA2
HOXB1 Ensembl NCBI GeneCards UniProt	ENSG00000120094.6	HOXB1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
HOXA2	chr7_27142124_27142281	228	0.820740	0.84	4.9e-03	Click!
HOXA2	chr7_27142737_27142888	382	0.674861	0.84	5.1e-03	Click!
HOXA2	chr7_27140714_27141098	1524	0.169156	0.81	7.5e-03	Click!
HOXA2	chr7_27143124_27143275	769	0.384045	0.77	1.6e-02	Click!
HOXA2	chr7_27142394_27142575	54	0.930137	0.74	2.2e-02	Click!
HOXB1	chr17_46606887_46607038	1310	0.246061	0.74	2.3e-02	Click!
HOXB1	chr17_46607108_46607259	1089	0.300034	0.68	4.3e-02	Click!

Activity of the HOXA2_HOXB1 motif across conditions

Conditions sorted by the z-value of the HOXA2_HOXB1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr2_121494510_121494857	0.31	GLI2	GLI family zinc finger 2	860	0.74
chr9_34745263_34745414	0.24	FAM205A	family with sequence similarity 205, member A	15874	0.13
chr17_17317253_17317688	0.22	ENSG00000201741	.	46288	0.12
chr12_85305887_85306488	0.21	SLC6A15	solute carrier family 6 (neutral amino acid transporter), member 15	384	0.92
chr11_122072235_122072431	0.20	ENSG00000207994	.	49317	0.12
chr5_100168975_100169126	0.19	ENSG00000221263	.	16781	0.26
chr19_464760_464911	0.18	SHC2	SHC (Src homology 2 domain containing) transforming protein 2	3839	0.12
chr16_16115866_16116017	0.17	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	12228	0.24
chr3_159482295_159482916	0.16	IQCJ-SCHIP1	IQCJ-SCHIP1 readthrough	287	0.9
chr2_53971971_53972122	0.16	GPR75-ASB3	GPR75-ASB3 readthrough	20640	0.16
chr11_34706995_34707273	0.16	EHF	ets homologous factor	42960	0.19
chrX_45482024_45482567	0.15	ENSG00000207870	.	123399	0.06
chr2_54684400_54684738	0.15	SPTBN1	spectrin, beta, non-erythrocytic 1	171	0.97
chr1_83285095_83285395	0.15	LPHN2	latrophilin 2	839672	0.0
chr14_53158961_53159226	0.15	ERO1L	ERO1-like (S. cerevisiae)	3154	0.22
chr1_87244034_87244185	0.15	SH3GLB1	SH3-domain GRB2-like endophilin B1	73531	0.09
chr2_74968036_74968578	0.14	SEMA4F	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F	86869	0.07
chr7_22233477_22233744	0.14	RAPGEF5	Rap guanine nucleotide exchange factor (GEF) 5	83	0.98
chr15_74880905_74881056	0.14	CLK3	CDC-like kinase 3	19733	0.14
chr18_53214040_53214242	0.14	TCF4	transcription factor 4	36141	0.18
chr5_10757151_10757327	0.14	CTD-2154B17.4		3938	0.26
chr14_103588344_103588755	0.13	TNFAIP2	tumor necrosis factor, alpha-induced protein 2	1249	0.43
chr1_208137959_208138110	0.13	CD34	CD34 molecule	53287	0.17
chr21_43422426_43422615	0.13	ZBTB21	zinc finger and BTB domain containing 21	5646	0.21
chr7_5467738_5468320	0.13	TNRC18	trinucleotide repeat containing 18	2984	0.19
chr20_61468182_61468333	0.13	COL9A3	collagen, type IX, alpha 3	19094	0.11
chr11_96062035_96062186	0.13	ENSG00000266192	.	12492	0.2
chr2_222367084_222367382	0.13	EPHA4	EPH receptor A4	47	0.98
chr4_8702215_8702366	0.13	CPZ	carboxypeptidase Z	98593	0.07
chr13_30009560_30009804	0.13	MTUS2	microtubule associated tumor suppressor candidate 2	6836	0.28
chr7_100773540_100774051	0.13	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	3416	0.13
chr11_27739578_27739815	0.13	BDNF	brain-derived neurotrophic factor	1598	0.49
chr17_36623721_36623872	0.13	ARHGAP23	Rho GTPase activating protein 23	4384	0.19
chrX_130902480_130902797	0.12	ENSG00000200587	.	170346	0.03
chr9_27408498_27408649	0.12	RP11-298E2.2		16841	0.25
chr21_28215601_28215791	0.12	ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif, 1	163	0.97
chr10_105614245_105615135	0.12	SH3PXD2A	SH3 and PX domains 2A	474	0.82
chr18_74798828_74799607	0.12	MBP	myelin basic protein	18000	0.27
chr10_28491840_28491991	0.12	MPP7	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	35751	0.21
chr14_81893853_81894004	0.12	STON2	stonin 2	180	0.97
chr2_183225036_183225187	0.11	ENSG00000242121	.	46100	0.17
chr11_30606067_30606222	0.11	RP5-1024C24.1		434	0.82
chr14_50468177_50468632	0.11	C14orf182	chromosome 14 open reading frame 182	5834	0.2
chr16_5648936_5649087	0.11	RP11-124K4.1		12283	0.3
chr8_25793197_25793466	0.11	EBF2	early B-cell factor 2	47899	0.19
chr14_24019702_24019853	0.11	ZFHX2	zinc finger homeobox 2	1081	0.33
chr3_156480231_156480382	0.11	LEKR1	leucine, glutamate and lysine rich 1	63783	0.12
chr11_3181150_3181578	0.11	OSBPL5	oxysterol binding protein-like 5	1259	0.4
chr19_10736478_10736985	0.11	SLC44A2	solute carrier family 44 (choline transporter), member 2	530	0.65
chr18_9107793_9107944	0.11	NDUFV2	NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa	3788	0.2
chr8_22250007_22250158	0.11	SLC39A14	solute carrier family 39 (zinc transporter), member 14	261	0.91
chr7_75924108_75924402	0.11	ENSG00000263569	.	6147	0.16
chr12_132629597_132629942	0.11	NOC4L	nucleolar complex associated 4 homolog (S. cerevisiae)	460	0.65
chr6_102178821_102179006	0.11	GRIK2	glutamate receptor, ionotropic, kainate 2	54269	0.19
chr7_156851742_156851893	0.11	MNX1-AS1	MNX1 antisense RNA 1 (head to head)	48318	0.11
chr10_33620428_33620906	0.11	NRP1	neuropilin 1	2643	0.37
chr2_134391396_134391547	0.10	ENSG00000200708	.	37809	0.2
chr16_49890203_49890582	0.10	ZNF423	zinc finger protein 423	346	0.91
chrX_11456470_11456766	0.10	ARHGAP6	Rho GTPase activating protein 6	10725	0.3
chr17_71068251_71068402	0.10	SLC39A11	solute carrier family 39, member 11	17577	0.24
chr15_95869891_95870263	0.10	ENSG00000222076	.	418956	0.01
chr15_32976738_32976906	0.10	RP11-1000B6.2		11556	0.16
chr18_26092204_26092423	0.10	CDH2	cadherin 2, type 1, N-cadherin (neuronal)	334903	0.01
chr2_28178102_28178322	0.10	ENSG00000265321	.	41022	0.15
chr8_37378833_37379079	0.10	RP11-150O12.6		4417	0.31
chr10_110004648_110004799	0.10	ENSG00000222436	.	696345	0.0
chr10_5670766_5671061	0.10	ENSG00000240577	.	2513	0.27
chr3_98619314_98619465	0.10	DCBLD2	discoidin, CUB and LCCL domain containing 2	626	0.66
chr7_24576451_24576602	0.10	ENSG00000206877	.	425	0.89
chr17_39577204_39577355	0.10	KRT37	keratin 37	3496	0.11
chr5_159738704_159739455	0.09	CCNJL	cyclin J-like	404	0.84
chr3_129204924_129205100	0.09	IFT122	intraflagellar transport 122 homolog (Chlamydomonas)	2022	0.27
chr3_159451541_159451741	0.09	IQCJ-SCHIP1	IQCJ-SCHIP1 readthrough	29861	0.17
chr2_180990617_180990780	0.09	CWC22	CWC22 spliceosome-associated protein homolog (S. cerevisiae)	118858	0.07
chr7_123389310_123389704	0.09	RP11-390E23.6		385	0.47
chr9_86892548_86892699	0.09	RP11-380F14.2		511	0.86
chr17_38267528_38268059	0.09	MSL1	male-specific lethal 1 homolog (Drosophila)	10758	0.11
chr17_69972427_69972645	0.09	AC007461.1	Uncharacterized protein	63628	0.15
chr14_55137368_55137519	0.09	SAMD4A	sterile alpha motif domain containing 4A	84108	0.09
chr8_26370931_26371439	0.09	PNMA2	paraneoplastic Ma antigen 2	423	0.6
chr21_33244856_33245438	0.09	HUNK	hormonally up-regulated Neu-associated kinase	481	0.88
chr2_65804604_65804761	0.09	ENSG00000251900	.	22014	0.21
chr7_23509552_23510001	0.09	IGF2BP3	insulin-like growth factor 2 mRNA binding protein 3	310	0.88
chr7_131582308_131582459	0.09	ENSG00000252849	.	18698	0.25
chr7_44922681_44922832	0.09	ENSG00000264326	.	1357	0.26
chr3_72131377_72131562	0.09	ENSG00000212070	.	180110	0.03
chr8_59956242_59956393	0.09	RP11-328K2.1		50820	0.14
chr12_114844132_114844283	0.09	TBX5	T-box 5	318	0.89
chr8_116463616_116464117	0.09	TRPS1	trichorhinophalangeal syndrome I	40582	0.2
chr3_13689202_13689353	0.09	LINC00620	long intergenic non-protein coding RNA 620	2919	0.28
chr7_25891701_25892366	0.09	ENSG00000199085	.	97573	0.09
chr10_8201743_8201894	0.09	GATA3	GATA binding protein 3	105049	0.08
chr10_77168132_77169350	0.09	ENSG00000237149	.	5929	0.2
chr9_128512876_128513197	0.09	PBX3	pre-B-cell leukemia homeobox 3	2558	0.37
chr10_127779801_127780118	0.08	ENSG00000222740	.	54192	0.14
chr2_205180048_205180265	0.08	PARD3B	par-3 family cell polarity regulator beta	230360	0.02
chr5_15501266_15501663	0.08	FBXL7	F-box and leucine-rich repeat protein 7	83	0.99
chr2_114035017_114035267	0.08	PAX8	paired box 8	829	0.59
chr17_75471247_75471398	0.08	SEPT9	septin 9	3	0.97
chr4_160220043_160220341	0.08	ENSG00000216089	.	3326	0.3
chr2_42796417_42796822	0.08	MTA3	metastasis associated 1 family, member 3	95	0.98
chr15_37394480_37395011	0.08	MEIS2	Meis homeobox 2	1241	0.49
chr3_61580182_61580471	0.08	PTPRG	protein tyrosine phosphatase, receptor type, G	32741	0.25
chr12_47671859_47672010	0.08	RP11-493L12.3		870	0.66
chr3_68697737_68697888	0.08	ENSG00000212095	.	13745	0.3
chr12_25877270_25877421	0.08	ENSG00000222950	.	55158	0.14
chr11_61780107_61780258	0.08	AP003733.1	Uncharacterized protein; cDNA FLJ36460 fis, clone THYMU2014801	44729	0.1
chr2_27301899_27302732	0.08	EMILIN1	elastin microfibril interfacer 1	880	0.32
chr12_54672473_54672704	0.08	CBX5	chromobox homolog 5	1298	0.19
chr7_93485635_93485786	0.08	TFPI2	tissue factor pathway inhibitor 2	33772	0.15
chr5_134722208_134722661	0.08	H2AFY	H2A histone family, member Y	12467	0.16
chr12_123574141_123574292	0.08	PITPNM2	phosphatidylinositol transfer protein, membrane-associated 2	8336	0.19
chr4_6992958_6993109	0.08	AC097382.5		4035	0.13
chr3_78853664_78853815	0.08	ENSG00000240964	.	133703	0.05
chr2_235403849_235404784	0.08	ARL4C	ADP-ribosylation factor-like 4C	928	0.74
chr1_8202972_8203123	0.08	ENSG00000200975	.	63610	0.11
chr11_122028064_122028812	0.08	ENSG00000207994	.	5422	0.19
chr9_89069847_89070053	0.08	ENSG00000222293	.	31907	0.23
chr4_105747663_105747814	0.08	ENSG00000251906	.	148081	0.04
chr3_61549164_61549336	0.08	PTPRG	protein tyrosine phosphatase, receptor type, G	1665	0.55
chr10_99932028_99932445	0.08	R3HCC1L	R3H domain and coiled-coil containing 1-like	9596	0.25
chr16_85645006_85645418	0.08	GSE1	Gse1 coiled-coil protein	197	0.95
chr1_165868486_165868637	0.07	RP11-525G13.2		1359	0.44
chrX_106984928_106985096	0.07	TSC22D3	TSC22 domain family, member 3	19510	0.2
chr1_56547076_56547335	0.07	PIGQP1	phosphatidylinositol glycan anchor biosynthesis, class Q pseudogene 1	142252	0.05
chr10_102322629_102322843	0.07	HIF1AN	hypoxia inducible factor 1, alpha subunit inhibitor	27120	0.15
chr2_14896967_14897186	0.07	AC011897.1	Uncharacterized protein	121861	0.06
chr9_685775_685926	0.07	RP11-130C19.3		295	0.92
chr14_21093852_21094122	0.07	OR6S1	olfactory receptor, family 6, subfamily S, member 1	15863	0.1
chr1_84084018_84084169	0.07	ENSG00000223231	.	175467	0.03
chr15_33148553_33148741	0.07	FMN1	formin 1	31808	0.17
chr13_98826337_98826632	0.07	RNF113B	ring finger protein 113B	3035	0.21
chr5_59508772_59508923	0.07	PDE4D	phosphodiesterase 4D, cAMP-specific	27422	0.24
chr21_42213476_42213627	0.07	DSCAM	Down syndrome cell adhesion molecule	5514	0.33
chr19_5681315_5681466	0.07	RPL36	ribosomal protein L36	197	0.45
chr5_17021245_17021396	0.07	BASP1	brain abundant, membrane attached signal protein 1	44387	0.15
chr14_88921501_88921652	0.07	PTPN21	protein tyrosine phosphatase, non-receptor type 21	14384	0.17
chr4_172734546_172734879	0.07	GALNTL6	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	58	0.99
chr3_169377883_169378034	0.07	MECOM	MDS1 and EVI1 complex locus	3220	0.23
chr10_63734627_63734778	0.07	ENSG00000221272	.	47925	0.17
chr2_138723355_138723506	0.07	HNMT	histamine N-methyltransferase	1387	0.61
chr5_14265991_14266171	0.07	TRIO	trio Rho guanine nucleotide exchange factor	25005	0.28
chr16_88228496_88228647	0.07	BANP	BTG3 associated nuclear protein	224947	0.02
chr3_98612768_98613177	0.07	DCBLD2	discoidin, CUB and LCCL domain containing 2	7043	0.19
chr6_142335140_142335592	0.07	RP11-137J7.2		74004	0.11
chr1_87239567_87240110	0.07	SH3GLB1	SH3-domain GRB2-like endophilin B1	69260	0.09
chr6_33384595_33384833	0.07	CUTA	cutA divalent cation tolerance homolog (E. coli)	984	0.34
chr7_83823215_83823431	0.07	SEMA3A	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	894	0.76
chr18_45968069_45968289	0.07	ZBTB7C	zinc finger and BTB domain containing 7C	31056	0.17
chr1_54793079_54793243	0.07	RP5-997D24.3		42083	0.14
chr1_21650807_21651093	0.07	ECE1	endothelin converting enzyme 1	21047	0.18
chr2_31636273_31636424	0.07	XDH	xanthine dehydrogenase	1233	0.61
chr10_94581983_94582410	0.07	EXOC6	exocyst complex component 6	8739	0.28
chr16_65566073_65566543	0.07	CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	410040	0.01
chr16_51465176_51465516	0.07	ENSG00000223168	.	240128	0.02
chr3_52140725_52140876	0.07	LINC00696	long intergenic non-protein coding RNA 696	43233	0.09
chr4_102267340_102267537	0.07	PPP3CA	protein phosphatase 3, catalytic subunit, alpha isozyme	515	0.73
chr6_163664912_163665063	0.07	ENSG00000239136	.	17045	0.25
chr4_26203423_26203574	0.07	RBPJ	recombination signal binding protein for immunoglobulin kappa J region	38421	0.23
chr3_42697942_42698093	0.07	RP4-613B23.1		2137	0.17
chr4_159732250_159732401	0.07	FNIP2	folliculin interacting protein 2	4925	0.23
chr18_61148002_61148153	0.06	SERPINB5	serpin peptidase inhibitor, clade B (ovalbumin), member 5	3717	0.21
chr8_135790645_135790802	0.06	ENSG00000207582	.	22127	0.21
chrX_123128269_123128420	0.06	STAG2	stromal antigen 2	31324	0.2
chr4_143739251_143739537	0.06	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	28049	0.27
chr18_4269017_4269168	0.06	DLGAP1-AS5	DLGAP1 antisense RNA 5	4459	0.35
chr11_12699867_12700018	0.06	TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	2892	0.38
chr19_914980_915131	0.06	R3HDM4	R3H domain containing 4	1815	0.15
chr2_12458046_12458293	0.06	ENSG00000207183	.	93458	0.09
chr15_72529055_72529849	0.06	PKM	pyruvate kinase, muscle	5288	0.17
chr12_21927150_21927652	0.06	KCNJ8	potassium inwardly-rectifying channel, subfamily J, member 8	354	0.86
chr4_157862974_157863267	0.06	PDGFC	platelet derived growth factor C	28935	0.19
chr2_100635044_100635528	0.06	AFF3	AF4/FMR2 family, member 3	85706	0.09
chr2_85640026_85640421	0.06	CAPG	capping protein (actin filament), gelsolin-like	939	0.34
chr7_6309088_6309239	0.06	CYTH3	cytohesin 3	3112	0.25
chr8_131144625_131144776	0.06	ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	13932	0.2
chr1_164535324_164535475	0.06	PBX1	pre-B-cell leukemia homeobox 1	3357	0.34
chr5_142625895_142626046	0.06	ARHGAP26	Rho GTPase activating protein 26	39205	0.19
chr6_121756849_121757212	0.06	GJA1	gap junction protein, alpha 1, 43kDa	192	0.94
chr7_2235658_2235809	0.06	MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	27530	0.17
chr10_53222210_53222361	0.06	RP11-539E19.2		159959	0.04
chr4_184827832_184828262	0.06	STOX2	storkhead box 2	1538	0.51
chr17_4711009_4711212	0.06	PLD2	phospholipase D2	253	0.82
chr7_16168928_16169137	0.06	ISPD-AS1	ISPD antisense RNA 1	81081	0.11
chr7_17315289_17315760	0.06	AC003075.4		5403	0.27
chr10_11872880_11873031	0.06	PROSER2	proline and serine-rich protein 2	727	0.72
chr14_21731452_21731695	0.06	HNRNPC	heterogeneous nuclear ribonucleoprotein C (C1/C2)	737	0.64
chr14_62232461_62232666	0.06	SNAPC1	small nuclear RNA activating complex, polypeptide 1, 43kDa	3488	0.33
chr10_119312526_119312804	0.06	EMX2OS	EMX2 opposite strand/antisense RNA	8086	0.24
chr6_164616974_164617125	0.06	ENSG00000266128	.	355456	0.01
chr6_168719854_168720005	0.06	DACT2	dishevelled-binding antagonist of beta-catenin 2	461	0.86
chr6_76458966_76459788	0.06	MYO6	myosin VI	328	0.89
chr7_39641818_39642080	0.06	AC004837.4		7940	0.18
chr17_62655006_62655429	0.06	SMURF2	SMAD specific E3 ubiquitin protein ligase 2	2813	0.3
chr10_102505217_102505492	0.06	PAX2	paired box 2	114	0.98
chr22_46460492_46460792	0.06	RP6-109B7.4		5129	0.11
chr16_66752038_66752189	0.06	RP11-63M22.2		2687	0.2
chr11_119583124_119583275	0.06	PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	16064	0.18
chr1_26496798_26497060	0.06	RP11-96L14.7		375	0.52
chr6_8434475_8434734	0.06	SLC35B3	solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3	1112	0.69

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA2_HOXB1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.1	0.2	GO:0015803	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0	0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.1	GO:0015868	purine ribonucleotide transport(GO:0015868)
0.0	0.1	GO:0060976	coronary vasculature development(GO:0060976)
0.0	0.1	GO:0072161	mesenchymal cell differentiation involved in kidney development(GO:0072161) metanephric mesenchymal cell differentiation(GO:0072162) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0	0.1	GO:0010107	potassium ion import(GO:0010107)
0.0	0.2	GO:0007184	SMAD protein import into nucleus(GO:0007184)
0.0	0.0	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.1	GO:0061384	heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0	0.0	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.1	GO:1901889	negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0031512	motile primary cilium(GO:0031512)
0.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.2	GO:0008091	spectrin(GO:0008091)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.1	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.1	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	GO:0030151	molybdenum ion binding(GO:0030151)
0.0	GO:0030215	semaphorin receptor binding(GO:0030215)
0.1	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	GO:0001159	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.0	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.2	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.1	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.2	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters