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ENCODE: H3K4me3 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for HOXB13

Z-value: 0.92

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Transcription factors associated with HOXB13

Gene Symbol Gene ID Gene Info
HOXB13
ENSG00000159184.7 HOXB13

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
HOXB13chr17_46805922_468061634980.6446550.107.9e-01Click!

Activity of the HOXB13 motif across conditions

Conditions sorted by the z-value of the HOXB13 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr4_109086470_109087224 0.66 LEF1
 lymphoid enhancer-binding factor 1
 610
 0.72
chr3_151964474_151964662 0.53 MBNL1
 muscleblind-like splicing regulator 1
 21261
 0.21
chr1_248729795_248729949 0.45 RP11-438F14.3
3971
 0.12
chr3_63954713_63955178 0.45 ATXN7
 ataxin 7
 1525
 0.34
chr11_5246641_5246814 0.43 ENSG00000221031
 .
 858
 0.32
chr13_110441094_110441245 0.43 IRS2
 insulin receptor substrate 2
 2254
 0.42
chr5_80257520_80257735 0.43 CTC-459I6.1
901
 0.48
chr2_173305484_173305639 0.43 AC078883.4
12230
 0.17
chr14_22974481_22974956 0.42 TRAJ51
 T cell receptor alpha joining 51 (pseudogene)
 18547
 0.09
chr1_167458198_167458349 0.42 CD247
 CD247 molecule
 29502
 0.16
chr2_143889174_143889389 0.40 ARHGAP15
 Rho GTPase activating protein 15
 2398
 0.38
chr1_22402292_22402667 0.39 CDC42-IT1
 CDC42 intronic transcript 1 (non-protein coding)
 16789
 0.13
chr9_100682755_100682906 0.39 C9orf156
 chromosome 9 open reading frame 156
 1939
 0.27
chr13_41589998_41590808 0.39 ELF1
 E74-like factor 1 (ets domain transcription factor)
 3047
 0.26
chr9_4285477_4285628 0.38 GLIS3
 GLIS family zinc finger 3
 12944
 0.21
chr4_39033572_39034012 0.36 TMEM156
 transmembrane protein 156
 249
 0.93
chr2_106412175_106412698 0.36 NCK2
 NCK adaptor protein 2
 20579
 0.25
chr16_1430217_1430368 0.35 UNKL
 unkempt family zinc finger-like
 605
 0.41
chr3_59996849_59997073 0.35 NPCDR1
 nasopharyngeal carcinoma, down-regulated 1
 39378
 0.24
chrX_78200973_78201449 0.35 P2RY10
 purinergic receptor P2Y, G-protein coupled, 10
 293
 0.95
chr6_109196078_109196273 0.35 ARMC2
 armadillo repeat containing 2
 5994
 0.26
chr4_154412529_154412680 0.33 KIAA0922
 KIAA0922
 25103
 0.22
chr7_19955546_19955697 0.33 AC005062.2
52239
 0.16
chr4_39660337_39660488 0.32 SMIM14
 small integral membrane protein 14
 19702
 0.16
chr4_26858665_26858816 0.31 STIM2
 stromal interaction molecule 2
 560
 0.8
chr14_102278079_102278230 0.30 CTD-2017C7.2
1496
 0.3
chr4_40210765_40210916 0.30 RHOH
 ras homolog family member H
 8876
 0.22
chr15_81586633_81587120 0.30 IL16
 interleukin 16
 2378
 0.31
chr2_87830138_87830289 0.30 RP11-1399P15.1
52660
 0.16
chr21_34697768_34697948 0.29 IFNAR1
 interferon (alpha, beta and omega) receptor 1
 580
 0.74
chr12_25206187_25206540 0.29 LRMP
 lymphoid-restricted membrane protein
 689
 0.71
chr7_35730534_35730808 0.29 HERPUD2
 HERPUD family member 2
 3505
 0.27
chr7_136976771_136976922 0.29 ENSG00000202023
 .
 4412
 0.31
chr17_46506355_46506700 0.29 SKAP1
 src kinase associated phosphoprotein 1
 1025
 0.46
chr2_111616545_111616696 0.28 ACOXL
 acyl-CoA oxidase-like
 53724
 0.17
chr5_150460010_150460252 0.27 TNIP1
 TNFAIP3 interacting protein 1
 446
 0.84
chr18_60985812_60986160 0.27 BCL2
 B-cell CLL/lymphoma 2
 59
 0.97
chr2_112177530_112177803 0.27 ENSG00000266139
 .
 98998
 0.09
chr20_10600368_10600683 0.27 JAG1
 jagged 1
 42629
 0.18
chr19_42056498_42056882 0.27 CEACAM21
 carcinoembryonic antigen-related cell adhesion molecule 21
 804
 0.6
chr1_198620599_198620750 0.27 PTPRC
 protein tyrosine phosphatase, receptor type, C
 12382
 0.23
chr10_121487824_121487975 0.27 INPP5F
 inositol polyphosphate-5-phosphatase F
 2290
 0.34
chr4_39032194_39032374 0.27 TMEM156
 transmembrane protein 156
 1757
 0.38
chr16_81748402_81748687 0.26 PLCG2
 phospholipase C, gamma 2 (phosphatidylinositol-specific)
 24158
 0.24
chr16_87825792_87825943 0.26 KLHDC4
 kelch domain containing 4
 26285
 0.14
chr5_14039928_14040178 0.26 DNAH5
 dynein, axonemal, heavy chain 5
 95401
 0.09
chr1_112167264_112167415 0.26 RAP1A
 RAP1A, member of RAS oncogene family
 4570
 0.2
chr6_27099516_27099912 0.26 HIST1H2BJ
 histone cluster 1, H2bj
 613
 0.5
chr2_68379959_68380110 0.26 WDR92
 WD repeat domain 92
 4571
 0.18
chr11_5713127_5713492 0.25 TRIM22
 tripartite motif containing 22
 1052
 0.38
chr16_9189012_9189240 0.24 C16orf72
 chromosome 16 open reading frame 72
 3621
 0.19
chr17_74656206_74656421 0.24 ENSG00000199735
 .
 3911
 0.11
chr18_9150083_9150234 0.24 ANKRD12
 ankyrin repeat domain 12
 12597
 0.16
chr3_98610682_98610833 0.24 DCBLD2
 discoidin, CUB and LCCL domain containing 2
 9258
 0.18
chr13_109783688_109783839 0.24 MYO16-AS2
 MYO16 antisense RNA 2
 29496
 0.24
chr12_96042633_96042784 0.23 ENSG00000212448
 .
 31243
 0.19
chr9_128586328_128586530 0.23 PBX3
 pre-B-cell leukemia homeobox 3
 41121
 0.2
chr6_53174830_53174981 0.23 ENSG00000264056
 .
 33114
 0.15
chr6_21109076_21109227 0.22 ENSG00000252046
 .
 115352
 0.07
chr17_64818195_64818346 0.22 CACNG5
 calcium channel, voltage-dependent, gamma subunit 5
 12965
 0.2
chr10_23634424_23634575 0.22 C10orf67
 chromosome 10 open reading frame 67
 725
 0.59
chr18_28567286_28567437 0.21 ENSG00000251702
 .
 3289
 0.27
chr11_128894218_128894369 0.21 ARHGAP32
 Rho GTPase activating protein 32
 205
 0.94
chr1_111212136_111212287 0.21 KCNA3
 potassium voltage-gated channel, shaker-related subfamily, member 3
 5444
 0.2
chr4_148982006_148982383 0.21 RP11-76G10.1
85428
 0.1
chr4_129732983_129734245 0.21 JADE1
 jade family PHD finger 1
 615
 0.83
chr17_19702847_19702998 0.21 ULK2
 unc-51 like autophagy activating kinase 2
 3482
 0.23
chr10_105670292_105670878 0.21 OBFC1
 oligonucleotide/oligosaccharide-binding fold containing 1
 6842
 0.18
chr11_104715007_104715158 0.20 CASP12
 caspase 12 (gene/pseudogene)
 54059
 0.14
chr2_99345755_99346000 0.20 MGAT4A
 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
 834
 0.68
chr2_160817314_160817486 0.20 LY75-CD302
 LY75-CD302 readthrough
 56179
 0.13
chr18_2662663_2662814 0.20 SMCHD1
 structural maintenance of chromosomes flexible hinge domain containing 1
 6852
 0.17
chr6_44214898_44215120 0.20 HSP90AB1
 heat shock protein 90kDa alpha (cytosolic), class B member 1
 185
 0.9
chr15_94040362_94040513 0.20 ENSG00000212063
 .
 210885
 0.02
chr21_20920825_20920976 0.20 ENSG00000212609
 .
 203435
 0.03
chr20_52446261_52446776 0.19 AC005220.3
110181
 0.06
chr14_102283767_102283918 0.19 CTD-2017C7.2
7184
 0.15
chr10_22938432_22938680 0.19 PIP4K2A
 phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
 57914
 0.15
chr13_48984563_48985023 0.19 LPAR6
 lysophosphatidic acid receptor 6
 16250
 0.26
chr3_60061066_60061217 0.19 NPCDR1
 nasopharyngeal carcinoma, down-regulated 1
 103558
 0.09
chr2_237446083_237446280 0.19 IQCA1
 IQ motif containing with AAA domain 1
 29996
 0.19
chr16_84766426_84766761 0.19 USP10
 ubiquitin specific peptidase 10
 32947
 0.16
chr21_25801249_25801648 0.19 ENSG00000232512
 .
 671997
 0.0
chr20_54993887_54994066 0.19 CASS4
 Cas scaffolding protein family member 4
 6659
 0.14
chr13_99953472_99953749 0.19 GPR183
 G protein-coupled receptor 183
 6049
 0.22
chr11_67009621_67010037 0.19 KDM2A
 lysine (K)-specific demethylase 2A
 2311
 0.2
chr1_26453918_26454263 0.18 PDIK1L
 PDLIM1 interacting kinase 1 like
 15750
 0.1
chr14_22466666_22466817 0.18 ENSG00000238634
 .
 144146
 0.04
chr6_27833598_27833859 0.18 HIST1H2AL
 histone cluster 1, H2al
 694
 0.38
chr10_74008100_74008285 0.18 DDIT4
 DNA-damage-inducible transcript 4
 25486
 0.12
chr2_198169992_198170200 0.18 ANKRD44-IT1
 ANKRD44 intronic transcript 1 (non-protein coding)
 2853
 0.22
chr11_59383655_59383910 0.18 AP000442.1
120
 0.56
chr6_34283507_34283709 0.18 C6orf1
 chromosome 6 open reading frame 1
 66361
 0.09
chr12_9103508_9103764 0.18 KLRG1
 killer cell lectin-like receptor subfamily G, member 1
 996
 0.36
chr12_43354342_43354493 0.17 ENSG00000215993
 .
 330966
 0.01
chrX_135861825_135862156 0.17 ARHGEF6
 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
 2257
 0.28
chr13_74159314_74159465 0.17 ENSG00000206697
 .
 358105
 0.01
chr13_114240659_114240810 0.17 TFDP1
 transcription factor Dp-1
 993
 0.58
chr3_31575511_31576107 0.17 STT3B
 STT3B, subunit of the oligosaccharyltransferase complex (catalytic)
 1527
 0.55
chr5_40683307_40683699 0.17 PTGER4
 prostaglandin E receptor 4 (subtype EP4)
 3903
 0.25
chr15_60841858_60842044 0.17 CTD-2501E16.2
19779
 0.18
chr15_31631556_31631837 0.17 KLF13
 Kruppel-like factor 13
 440
 0.9
chr12_104858566_104858717 0.17 CHST11
 carbohydrate (chondroitin 4) sulfotransferase 11
 7862
 0.28
chr5_79514748_79514899 0.16 ENSG00000239159
 .
 20585
 0.18
chr20_3137491_3137642 0.16 UBOX5
 U-box domain containing 5
 2956
 0.15
chr20_31988765_31988916 0.16 CDK5RAP1
 CDK5 regulatory subunit associated protein 1
 483
 0.8
chr14_22984271_22984422 0.16 TRAJ15
 T cell receptor alpha joining 15
 14234
 0.1
chr1_236960314_236960595 0.16 MTR
 5-methyltetrahydrofolate-homocysteine methyltransferase
 1472
 0.52
chr2_197024603_197024962 0.16 STK17B
 serine/threonine kinase 17b
 3411
 0.25
chr6_144163877_144164309 0.16 LTV1
 LTV1 homolog (S. cerevisiae)
 388
 0.89
chr7_41921705_41921953 0.16 AC005027.3
176896
 0.03
chr3_166970881_166971032 0.16 ZBBX
 zinc finger, B-box domain containing
 119820
 0.06
chr1_199582224_199582375 0.16 ENSG00000263805
 .
 2109
 0.48
chr1_149816150_149816668 0.16 HIST2H2AA3
 histone cluster 2, H2aa3
 1931
 0.11
chrX_78206486_78206637 0.16 P2RY10
 purinergic receptor P2Y, G-protein coupled, 10
 5643
 0.34
chr5_67176974_67177125 0.16 ENSG00000223149
 .
 86224
 0.11
chr12_4384723_4384874 0.16 CCND2
 cyclin D2
 432
 0.41
chr22_29206752_29206905 0.16 CTA-292E10.8
4074
 0.17
chr6_26251322_26251789 0.16 HIST1H2BH
 histone cluster 1, H2bh
 324
 0.6
chr14_65734381_65734532 0.16 ENSG00000266740
 .
 67445
 0.11
chr7_115851873_115852024 0.15 TES
 testis derived transcript (3 LIM domains)
 1345
 0.49
chr11_113644591_113644812 0.15 ZW10
 zw10 kinetochore protein
 168
 0.92
chr1_67400477_67400653 0.15 MIER1
 mesoderm induction early response 1, transcriptional regulator
 4639
 0.23
chr6_170862470_170862790 0.15 PSMB1
 proteasome (prosome, macropain) subunit, beta type, 1
 201
 0.86
chr6_159237653_159237805 0.15 EZR-AS1
 EZR antisense RNA 1
 1314
 0.35
chr9_276345_276496 0.15 DOCK8
 dedicator of cytokinesis 8
 3350
 0.24
chr1_158811509_158811660 0.15 MNDA
 myeloid cell nuclear differentiation antigen
 4107
 0.23
chr3_151963279_151963566 0.15 MBNL1
 muscleblind-like splicing regulator 1
 22407
 0.21
chr7_150440682_150440833 0.15 GIMAP5
 GTPase, IMAP family member 5
 6321
 0.17
chr4_83349699_83350038 0.15 HNRNPDL
 heterogeneous nuclear ribonucleoprotein D-like
 726
 0.59
chr1_190136920_190137071 0.15 RP11-547I7.1
97033
 0.09
chr11_34126778_34126978 0.15 NAT10
 N-acetyltransferase 10 (GCN5-related)
 271
 0.94
chr3_16927612_16928071 0.15 PLCL2
 phospholipase C-like 2
 1389
 0.54
chr1_176174683_176175792 0.15 RFWD2
 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
 280
 0.89
chrX_121293446_121293597 0.15 ENSG00000221217
 .
 290801
 0.01
chr10_7526759_7527322 0.15 ENSG00000207453
 .
 1731
 0.45
chr5_148725564_148725728 0.15 GRPEL2
 GrpE-like 2, mitochondrial (E. coli)
 581
 0.64
chr19_48751391_48751542 0.14 CARD8
 caspase recruitment domain family, member 8
 1459
 0.28
chr16_89181351_89181649 0.14 CTD-2555A7.3
187
 0.93
chr2_119613988_119614139 0.14 EN1
 engrailed homeobox 1
 8809
 0.28
chr1_160676943_160677601 0.14 CD48
 CD48 molecule
 4321
 0.18
chr6_149386973_149387124 0.14 RP11-162J8.3
33339
 0.2
chr22_32858699_32858850 0.14 BPIFC
 BPI fold containing family C
 1655
 0.35
chr10_90751494_90751719 0.14 ACTA2
 actin, alpha 2, smooth muscle, aorta
 459
 0.66
chr13_46755525_46755771 0.14 LCP1
 lymphocyte cytosolic protein 1 (L-plastin)
 811
 0.58
chr13_75840765_75840916 0.14 ENSG00000266534
 .
 57667
 0.14
chr3_47203422_47203573 0.14 SETD2
 SET domain containing 2
 1569
 0.35
chr16_25072169_25072320 0.14 ARHGAP17
 Rho GTPase activating protein 17
 45257
 0.14
chr1_84767342_84767579 0.14 SAMD13
 sterile alpha motif domain containing 13
 57
 0.98
chr15_93429972_93430811 0.14 CHD2
 chromodomain helicase DNA binding protein 2
 3865
 0.22
chr4_40205321_40205527 0.14 RHOH
 ras homolog family member H
 3460
 0.27
chr7_24576141_24576292 0.14 ENSG00000206877
 .
 735
 0.75
chr10_3514525_3515428 0.14 RP11-184A2.3
278283
 0.01
chr11_128609410_128609561 0.14 FLI1
 Fli-1 proto-oncogene, ETS transcription factor
 25200
 0.18
chr14_99710021_99710272 0.14 AL109767.1
19139
 0.2
chr14_58711962_58712794 0.14 PSMA3
 proteasome (prosome, macropain) subunit, alpha type, 3
 756
 0.54
chr4_148539335_148539606 0.14 TMEM184C
 transmembrane protein 184C
 933
 0.44
chr7_150414088_150414577 0.13 GIMAP1
 GTPase, IMAP family member 1
 687
 0.65
chrX_78412852_78413003 0.13 GPR174
 G protein-coupled receptor 174
 13542
 0.31
chr8_19613768_19613970 0.13 CSGALNACT1
 chondroitin sulfate N-acetylgalactosaminyltransferase 1
 947
 0.69
chr17_66202564_66202990 0.13 AMZ2
 archaelysin family metallopeptidase 2
 40938
 0.12
chr4_146541198_146541349 0.13 MMAA
 methylmalonic aciduria (cobalamin deficiency) cblA type
 1858
 0.37
chr2_143887894_143888150 0.13 ARHGAP15
 Rho GTPase activating protein 15
 1139
 0.61
chr14_97925415_97925566 0.13 ENSG00000240730
 .
 71020
 0.14
chrX_56756434_56756710 0.13 ENSG00000204272
 .
 880
 0.75
chr1_65534522_65534674 0.13 ENSG00000199135
 .
 10407
 0.19
chr11_66035600_66035751 0.13 RP11-867G23.2
75
 0.76
chr4_130846311_130846462 0.13 ENSG00000222861
 .
 64731
 0.16
chr8_67974970_67975187 0.13 CSPP1
 centrosome and spindle pole associated protein 1
 417
 0.53
chr7_152133952_152134604 0.13 KMT2C
 lysine (K)-specific methyltransferase 2C
 1188
 0.44
chr17_10603321_10603720 0.13 ADPRM
 ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
 2609
 0.18
chr2_85166549_85166831 0.13 KCMF1
 potassium channel modulatory factor 1
 31526
 0.15
chr11_12218163_12218314 0.13 MICAL2
 microtubule associated monooxygenase, calponin and LIM domain containing 2
 34535
 0.18
chrX_18444690_18444905 0.13 CDKL5
 cyclin-dependent kinase-like 5
 1094
 0.59
chr11_102724997_102725148 0.13 MMP3
 matrix metallopeptidase 3 (stromelysin 1, progelatinase)
 10538
 0.19
chr16_71916638_71916789 0.13 RP11-498D10.3
537
 0.48
chr13_87919295_87919446 0.13 ENSG00000266052
 .
 351625
 0.01
chr11_95881357_95881508 0.13 ENSG00000266192
 .
 193170
 0.03
chr1_228336510_228336661 0.13 GJC2
 gap junction protein, gamma 2, 47kDa
 968
 0.38
chr2_42979871_42980022 0.13 OXER1
 oxoeicosanoid (OXE) receptor 1
 11455
 0.21
chr16_71933280_71933431 0.13 IST1
 increased sodium tolerance 1 homolog (yeast)
 3863
 0.15
chr8_29936071_29936255 0.13 TMEM66
 transmembrane protein 66
 3777
 0.18
chr4_25333211_25333559 0.13 ZCCHC4
 zinc finger, CCHC domain containing 4
 1498
 0.44
chr15_95740241_95740392 0.12 ENSG00000222076
 .
 548717
 0.0
chr10_69609625_69609925 0.12 DNAJC12
 DnaJ (Hsp40) homolog, subfamily C, member 12
 11853
 0.17
chr2_178187798_178187949 0.12 AC074286.1
19
 0.96
chr8_9156944_9157095 0.12 ENSG00000207415
 .
 11931
 0.25
chr6_139458867_139459205 0.12 HECA
 headcase homolog (Drosophila)
 2787
 0.35
chr1_145507666_145508470 0.12 RP11-315I20.1
80
 0.83
chr1_31407657_31407808 0.12 ENSG00000200154
 .
 888
 0.51
chr2_87799012_87799242 0.12 RP11-1399P15.1
21574
 0.26
chr2_201981847_201982480 0.12 CFLAR
 CASP8 and FADD-like apoptosis regulator
 401
 0.79
chr2_9315047_9315328 0.12 ASAP2
 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
 31707
 0.23
chr13_99992298_99992449 0.12 ENSG00000207719
 .
 16012
 0.19
chr6_10310725_10311140 0.12 ENSG00000221583
 .
 88663
 0.07
chr17_37356079_37356230 0.12 RPL19
 ribosomal protein L19
 382
 0.77
chrX_45210737_45210888 0.12 RP11-342D14.1
31109
 0.25
chr18_68289401_68289560 0.12 GTSCR1
 Gilles de la Tourette syndrome chromosome region, candidate 1
 28467
 0.25
chrX_48858741_48859359 0.12 GRIPAP1
 GRIP1 associated protein 1
 375
 0.74
chr11_58340730_58341020 0.12 LPXN
 leupaxin
 2459
 0.23

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of HOXB13

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0032714 negative regulation of interleukin-5 production(GO:0032714)
0.1 0.3 GO:0045636 positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.1 0.3 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.2 GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0 0.1 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.1 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.1 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0 0.2 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.1 GO:0034421 post-translational protein acetylation(GO:0034421)
0.0 0.2 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.1 GO:0006562 proline catabolic process(GO:0006562)
0.0 0.1 GO:0002323 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0 0.1 GO:0032071 regulation of endodeoxyribonuclease activity(GO:0032071)
0.0 0.2 GO:0050860 negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.0 GO:0060398 regulation of growth hormone receptor signaling pathway(GO:0060398)
0.0 0.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.1 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.1 GO:0060605 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.1 GO:0035844 cloaca development(GO:0035844) cloacal septation(GO:0060197)
0.0 0.0 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.1 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.1 GO:0048859 formation of anatomical boundary(GO:0048859)
0.0 0.0 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.0 0.1 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.0 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.0 0.1 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.0 0.1 GO:0033160 positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0 0.1 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.0 0.4 GO:0060338 regulation of type I interferon-mediated signaling pathway(GO:0060338)
0.0 0.1 GO:0030185 nitric oxide transport(GO:0030185)
0.0 0.1 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 0.2 GO:0006906 vesicle fusion(GO:0006906)
0.0 0.0 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.0 GO:0015864 pyrimidine nucleoside transport(GO:0015864)
0.0 0.1 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.0 0.1 GO:0002063 chondrocyte development(GO:0002063)
0.0 0.0 GO:0006927 obsolete transformed cell apoptotic process(GO:0006927)
0.0 0.0 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.0 GO:0042118 endothelial cell activation(GO:0042118)
0.0 0.0 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.0 GO:0003032 detection of oxygen(GO:0003032)
0.0 0.0 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.0 0.0 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) epithelial cell proliferation involved in lung morphogenesis(GO:0060502) regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.0 0.0 GO:0002468 dendritic cell antigen processing and presentation(GO:0002468) regulation of dendritic cell antigen processing and presentation(GO:0002604) positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0 0.2 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.0 GO:0034625 fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0 0.0 GO:0072033 renal vesicle formation(GO:0072033)
0.0 0.0 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.0 GO:0071459 protein localization to chromosome, centromeric region(GO:0071459)
0.0 0.0 GO:0043570 maintenance of DNA repeat elements(GO:0043570)
0.0 0.0 GO:0030910 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 GO:0001740 Barr body(GO:0001740)
0.0 0.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0070188 obsolete Stn1-Ten1 complex(GO:0070188)
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.1 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.1 GO:0042629 mast cell granule(GO:0042629)
0.0 0.1 GO:0002178 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.1 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 1.0 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.1 GO:0016342 catenin complex(GO:0016342)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 0.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.3 GO:0051400 BH domain binding(GO:0051400)
0.0 0.2 GO:0004904 interferon receptor activity(GO:0004904)
0.0 0.2 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.1 GO:0042808 obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0 0.0 GO:0032356 single guanine insertion binding(GO:0032142) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.1 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.1 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 0.6 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.1 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.1 GO:0098847 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.1 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.1 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.0 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.0 0.1 GO:0016531 copper chaperone activity(GO:0016531)
0.0 0.3 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.1 GO:0061659 ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 0.0 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.0 0.1 GO:0070696 transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0 0.1 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.1 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.0 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.0 0.1 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.0 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.1 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.2 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.3 PID IGF1 PATHWAY IGF1 pathway
0.0 0.0 ST GA12 PATHWAY G alpha 12 Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.5 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.3 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.0 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.2 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.2 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.1 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.1 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.2 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.1 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.0 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.6 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.1 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.1 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.2 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling